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Aliases for NMRAL1 Gene

Aliases for NMRAL1 Gene

  • NmrA Like Redox Sensor 1 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 48A, Member 1 2 3
  • NmrA-Like Family Domain Containing 1 2 3
  • HSCARG 3 4
  • NmrA-Like Family Domain-Containing Protein 1 3
  • SDR48A1 3

External Ids for NMRAL1 Gene

Previous GeneCards Identifiers for NMRAL1 Gene

  • GC16M004452
  • GC16M004512

Summaries for NMRAL1 Gene

Entrez Gene Summary for NMRAL1 Gene

  • This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for NMRAL1 Gene

NMRAL1 (NmrA Like Redox Sensor 1) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for NMRAL1 Gene

  • Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.

Additional gene information for NMRAL1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMRAL1 Gene

Genomics for NMRAL1 Gene

GeneHancer (GH) Regulatory Elements for NMRAL1 Gene

Promoters and enhancers for NMRAL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I004473 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 600.2 +19.6 19595 5.4 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 NMRAL1 HMOX2 CREBBP ZNF500 CDIP1 UBN1 NUDT16L1 ENSG00000261938 MGRN1 GC16P004473
GH16I004494 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 599.3 -0.2 -230 3.3 ZNF639 FOXA2 ZNF680 RARA ZNF121 JUND POLR2A BCL6B BCL6 FOS NMRAL1 HMOX2 CDIP1 NUDT16L1 GC16P004506
GH16I004407 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 38.1 +83.2 83226 10.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A FEZF1 IRF4 SLC30A9 POLR2B CORO7 CORO7-PAM16 NMRAL1 HMOX2 MGRN1 NUDT16L1 VASN
GH16I004536 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.7 -42.4 -42428 2.6 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 CDIP1 C16orf96 ZNF500 NMRAL1 ANKS3 ENSG00000261938 CREBBP EEF2KMT HMOX2 GLIS2-AS1
GH16I004368 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.1 +121.5 121455 11 PKNOX1 CLOCK FOXA2 ARID4B SIN3A DMAP1 YY1 FOS KLF13 SP3 VASN NMRAL1 ANKS3 CREBBP ZNF500 ZSCAN32 ZNF174 HMOX2 CLUAP1 ENSG00000261938
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NMRAL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NMRAL1 gene promoter:

Genomic Locations for NMRAL1 Gene

Genomic Locations for NMRAL1 Gene
chr16:4,461,680-4,495,763
(GRCh38/hg38)
Size:
34,084 bases
Orientation:
Minus strand
chr16:4,511,681-4,545,764
(GRCh37/hg19)

Genomic View for NMRAL1 Gene

Genes around NMRAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMRAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMRAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMRAL1 Gene

Proteins for NMRAL1 Gene

  • Protein details for NMRAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBL8-NMRL1_HUMAN
    Recommended name:
    NmrA-like family domain-containing protein 1
    Protein Accession:
    Q9HBL8

    Protein attributes for NMRAL1 Gene

    Size:
    299 amino acids
    Molecular mass:
    33344 Da
    Quaternary structure:
    • Homodimer. Interacts with ASS1. Interaction is enhanced by low NADPH/NADP(+) ratios, which results in inhibition of ASS1 activity.
    Miscellaneous:
    • Reduced levels of NMRAL1 by RNAi increases nitric oxide production and reduces cell viability. Overexpression of NMRAL1 increases cell viability.

    Three dimensional structures from OCA and Proteopedia for NMRAL1 Gene

neXtProt entry for NMRAL1 Gene

Post-translational modifications for NMRAL1 Gene

  • Ubiquitination at isoforms=31, Lys133, isoforms=167, isoforms=206, Lys230, isoforms=248, and isoforms=281

No data available for DME Specific Peptides for NMRAL1 Gene

Domains & Families for NMRAL1 Gene

Gene Families for NMRAL1 Gene

Protein Domains for NMRAL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NMRAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBL8

UniProtKB/Swiss-Prot:

NMRL1_HUMAN :
  • Belongs to the NmrA-type oxidoreductase family.
Family:
  • Belongs to the NmrA-type oxidoreductase family.
genes like me logo Genes that share domains with NMRAL1: view

Function for NMRAL1 Gene

Molecular function for NMRAL1 Gene

UniProtKB/Swiss-Prot Function:
Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
UniProtKB/Swiss-Prot Induction:
By nitric oxide, cGMP and proinflammatory cytokines.

Phenotypes From GWAS Catalog for NMRAL1 Gene

Gene Ontology (GO) - Molecular Function for NMRAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17496144
GO:0042802 identical protein binding IPI 17496144
genes like me logo Genes that share ontologies with NMRAL1: view
genes like me logo Genes that share phenotypes with NMRAL1: view

Animal Models for NMRAL1 Gene

MGI Knock Outs for NMRAL1:

miRNA for NMRAL1 Gene

miRTarBase miRNAs that target NMRAL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NMRAL1 Gene

Localization for NMRAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMRAL1 Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMRAL1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NMRAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with NMRAL1: view

Pathways & Interactions for NMRAL1 Gene

genes like me logo Genes that share pathways with NMRAL1: view

Pathways by source for NMRAL1 Gene

Gene Ontology (GO) - Biological Process for NMRAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000050 urea cycle TAS --
genes like me logo Genes that share ontologies with NMRAL1: view

No data available for SIGNOR curated interactions for NMRAL1 Gene

Drugs & Compounds for NMRAL1 Gene

(1) Drugs for NMRAL1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID Experimental Pharma Target 0
genes like me logo Genes that share compounds with NMRAL1: view

Transcripts for NMRAL1 Gene

Unigene Clusters for NMRAL1 Gene

NmrA-like family domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMRAL1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: -
SP11: - -
SP12: - - - - - -

ExUns: 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for NMRAL1 Gene

GeneLoc Exon Structure for
NMRAL1
ECgene alternative splicing isoforms for
NMRAL1

Expression for NMRAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NMRAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NMRAL1 Gene

This gene is overexpressed in Bone (32.0) and Lung (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NMRAL1 Gene



Protein tissue co-expression partners for NMRAL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NMRAL1 Gene:

NMRAL1

SOURCE GeneReport for Unigene cluster for NMRAL1 Gene:

Hs.288969

Evidence on tissue expression from TISSUES for NMRAL1 Gene

  • Skin(4.3)
  • Adrenal gland(4.2)
genes like me logo Genes that share expression patterns with NMRAL1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMRAL1 Gene

Orthologs for NMRAL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMRAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMRAL1 33 34
  • 96.87 (n)
cow
(Bos Taurus)
Mammalia NMRAL1 33 34
  • 87.95 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 87 (a)
OneToMany
NMRAL1 33
  • 86.96 (n)
-- 34
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nmral1 33
  • 81.98 (n)
mouse
(Mus musculus)
Mammalia Nmral1 33 16 34
  • 81.83 (n)
oppossum
(Monodelphis domestica)
Mammalia NMRAL1 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMRAL1 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMRAL1 33 34
  • 70.72 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6029 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9998 33
Species where no ortholog for NMRAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NMRAL1 Gene

ENSEMBL:
Gene Tree for NMRAL1 (if available)
TreeFam:
Gene Tree for NMRAL1 (if available)

Paralogs for NMRAL1 Gene

(1) SIMAP similar genes for NMRAL1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for NMRAL1 Gene

genes like me logo Genes that share paralogs with NMRAL1: view

No data available for Paralogs for NMRAL1 Gene

Variants for NMRAL1 Gene

Sequence variations from dbSNP and Humsavar for NMRAL1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000031561 -- 4,474,460(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000063673 -- 4,462,890(-) C/G/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000293974 -- 4,470,240(-) G/A/T intron_variant
rs1000405418 -- 4,468,348(-) G/A intron_variant
rs1000491145 -- 4,465,761(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NMRAL1 Gene

Variant ID Type Subtype PubMed ID
esv23732 CNV gain 19812545
esv3584924 CNV gain 24956385
nsv1046986 CNV gain 25217958
nsv1160332 CNV duplication 26073780
nsv833132 CNV loss 17160897

Variation tolerance for NMRAL1 Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.93; 67.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NMRAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMRAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMRAL1 Gene

Disorders for NMRAL1 Gene

Additional Disease Information for NMRAL1

No disorders were found for NMRAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMRAL1 Gene

Publications for NMRAL1 Gene

  1. An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. (PMID: 18263583) Zhao Y … Zheng X (The Journal of biological chemistry 2008) 2 3 4 58
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 58
  3. NADPH is an allosteric regulator of HSCARG. (PMID: 19254724) Dai X … Zheng X (Journal of molecular biology 2009) 3 4 58
  4. Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein. (PMID: 17496144) Zheng X … Luo M (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for NMRAL1 Gene

Sources for NMRAL1 Gene

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