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Aliases for NMRAL1 Gene

Aliases for NMRAL1 Gene

  • NmrA Like Redox Sensor 1 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 48A, Member 1 2 3
  • NmrA-Like Family Domain Containing 1 2 3
  • HSCARG 3 4
  • NmrA-Like Family Domain-Containing Protein 1 3
  • SDR48A1 3

External Ids for NMRAL1 Gene

Previous GeneCards Identifiers for NMRAL1 Gene

  • GC16M004452
  • GC16M004512

Summaries for NMRAL1 Gene

Entrez Gene Summary for NMRAL1 Gene

  • This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for NMRAL1 Gene

NMRAL1 (NmrA Like Redox Sensor 1) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for NMRAL1 Gene

  • Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMRAL1 Gene

Genomics for NMRAL1 Gene

Regulatory Elements for NMRAL1 Gene

Enhancers for NMRAL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F004485 1.3 Ensembl ENCODE 52.9 +7.4 7372 6.2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 NMRAL1 CDIP1 HMOX2 CLUAP1 ZNF500 NUDT16L1 GLIS2 CORO7 MGRN1
GH16F004498 0.9 Ensembl ENCODE 50.6 -3.0 -3028 1.6 CTCF ZNF146 ARID4B FEZF1 ZNF384 RAD21 GATA3 SMC3 NFE2 ZNF654 NMRAL1 HMOX2 GC16P004506
GH16F004473 0.6 ENCODE 50.2 +19.6 19595 5.4 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 CBX5 NMRAL1 ZNF500 CREBBP CDIP1 HMOX2 NUDT16L1 MGRN1
GH16F004499 0.6 Ensembl ENCODE 49.7 -7.7 -7734 7.4 HDGF PKNOX1 WRNIP1 INSM2 SIN3A BMI1 FEZF1 ZNF2 RAD21 YY1 NMRAL1 HMOX2 CDIP1 PPL GC16P004506
GH16F004494 0.7 Ensembl ENCODE 49.2 -0.2 -231 3.3 ZNF639 ZNF680 RARA ZNF121 JUND ZNF366 ZNF512 BCL6 FOS SP7 NMRAL1 HMOX2 CDIP1 NUDT16L1 GC16P004506
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NMRAL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NMRAL1 Gene

Chromosome:
16
Start:
4,461,680 bp from pter
End:
4,495,763 bp from pter
Size:
34,084 bases
Orientation:
Minus strand

Genomic View for NMRAL1 Gene

Genes around NMRAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMRAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMRAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMRAL1 Gene

Proteins for NMRAL1 Gene

  • Protein details for NMRAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBL8-NMRL1_HUMAN
    Recommended name:
    NmrA-like family domain-containing protein 1
    Protein Accession:
    Q9HBL8

    Protein attributes for NMRAL1 Gene

    Size:
    299 amino acids
    Molecular mass:
    33344 Da
    Quaternary structure:
    • Homodimer. Interacts with ASS1. Interaction is enhanced by low NADPH/NADP(+) ratios, which results in inhibition of ASS1 activity.
    Miscellaneous:
    • Reduced levels of NMRAL1 by RNAi increases nitric oxide production and reduces cell viability. Overexpression of NMRAL1 increases cell viability.

    Three dimensional structures from OCA and Proteopedia for NMRAL1 Gene

neXtProt entry for NMRAL1 Gene

Post-translational modifications for NMRAL1 Gene

  • Ubiquitination at Lys 31, Lys 133, Lys 167, Lys 206, Lys 230, Lys 248, and Lys 281
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for NMRAL1
  • Santa Cruz Biotechnology (SCBT) Antibodies for NMRAL1

No data available for DME Specific Peptides for NMRAL1 Gene

Domains & Families for NMRAL1 Gene

Gene Families for NMRAL1 Gene

Protein Domains for NMRAL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NMRAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBL8

UniProtKB/Swiss-Prot:

NMRL1_HUMAN :
  • Belongs to the NmrA-type oxidoreductase family.
Family:
  • Belongs to the NmrA-type oxidoreductase family.
genes like me logo Genes that share domains with NMRAL1: view

Function for NMRAL1 Gene

Molecular function for NMRAL1 Gene

UniProtKB/Swiss-Prot Function:
Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
UniProtKB/Swiss-Prot Induction:
By nitric oxide, cGMP and proinflammatory cytokines.
genes like me logo Genes that share phenotypes with NMRAL1: view

Animal Models for NMRAL1 Gene

MGI Knock Outs for NMRAL1:

Animal Model Products

miRNA for NMRAL1 Gene

miRTarBase miRNAs that target NMRAL1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NMRAL1 Gene

Localization for NMRAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMRAL1 Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMRAL1 Gene COMPARTMENTS Subcellular localization image for NMRAL1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NMRAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with NMRAL1: view

Pathways & Interactions for NMRAL1 Gene

genes like me logo Genes that share pathways with NMRAL1: view

Pathways by source for NMRAL1 Gene

Gene Ontology (GO) - Biological Process for NMRAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000050 urea cycle TAS --
genes like me logo Genes that share ontologies with NMRAL1: view

No data available for SIGNOR curated interactions for NMRAL1 Gene

Drugs & Compounds for NMRAL1 Gene

(1) Drugs for NMRAL1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID Experimental Pharma Target 0
genes like me logo Genes that share compounds with NMRAL1: view

Transcripts for NMRAL1 Gene

Unigene Clusters for NMRAL1 Gene

NmrA-like family domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMRAL1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: -
SP11: - -
SP12: - - - - - -

ExUns: 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for NMRAL1 Gene

GeneLoc Exon Structure for
NMRAL1
ECgene alternative splicing isoforms for
NMRAL1

Expression for NMRAL1 Gene

mRNA expression in normal human tissues for NMRAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NMRAL1 Gene

This gene is overexpressed in Bone (32.0) and Lung (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NMRAL1 Gene



Protein tissue co-expression partners for NMRAL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NMRAL1 Gene:

NMRAL1

SOURCE GeneReport for Unigene cluster for NMRAL1 Gene:

Hs.288969
genes like me logo Genes that share expression patterns with NMRAL1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NMRAL1 Gene

Orthologs for NMRAL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMRAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMRAL1 34 35
  • 96.87 (n)
cow
(Bos Taurus)
Mammalia NMRAL1 34 35
  • 87.95 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 87 (a)
OneToMany
NMRAL1 34
  • 86.96 (n)
-- 35
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nmral1 34
  • 81.98 (n)
mouse
(Mus musculus)
Mammalia Nmral1 34 16 35
  • 81.83 (n)
oppossum
(Monodelphis domestica)
Mammalia NMRAL1 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMRAL1 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMRAL1 34 35
  • 70.72 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6029 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9998 34
Species where no ortholog for NMRAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NMRAL1 Gene

ENSEMBL:
Gene Tree for NMRAL1 (if available)
TreeFam:
Gene Tree for NMRAL1 (if available)

Paralogs for NMRAL1 Gene

(1) SIMAP similar genes for NMRAL1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for NMRAL1 Gene

genes like me logo Genes that share paralogs with NMRAL1: view

No data available for Paralogs for NMRAL1 Gene

Variants for NMRAL1 Gene

Sequence variations from dbSNP and Humsavar for NMRAL1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1043380 -- 4,461,891(-) CGTTT(C/T)TATGC reference, synonymous-codon, utr-variant-3-prime
rs10438587 -- 4,472,159(+) actga(C/T)gaatg intron-variant
rs10438588 -- 4,472,269(+) aaacc(C/G)cgtct intron-variant
rs111729887 -- 4,475,892(+) CGAGA(C/T)CACGT intron-variant, upstream-variant-2KB
rs111749218 -- 4,461,331(+) GGGAA(C/T)AGAGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NMRAL1 Gene

Variant ID Type Subtype PubMed ID
esv23732 CNV gain 19812545
esv3584924 CNV gain 24956385
nsv1046986 CNV gain 25217958
nsv1160332 CNV duplication 26073780
nsv833132 CNV loss 17160897

Variation tolerance for NMRAL1 Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.93; 67.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMRAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMRAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMRAL1 Gene

Disorders for NMRAL1 Gene

Relevant External Links for NMRAL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMRAL1

No disorders were found for NMRAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMRAL1 Gene

Publications for NMRAL1 Gene

  1. An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. (PMID: 18263583) Zhao Y. … Zheng X. (J. Biol. Chem. 2008) 2 3 4 64
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 64
  3. NADPH is an allosteric regulator of HSCARG. (PMID: 19254724) Dai X. … Zheng X. (J. Mol. Biol. 2009) 3 4 64
  4. Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein. (PMID: 17496144) Zheng X. … Luo M. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NMRAL1 Gene

Sources for NMRAL1 Gene

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