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Aliases for NMRAL1 Gene

Aliases for NMRAL1 Gene

  • NmrA-Like Family Domain Containing 1 2 3 5
  • HSCARG 3 4
  • Short Chain Dehydrogenase/Reductase Family 48A, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 48A 2
  • Member 1 2
  • SDR48A1 3

External Ids for NMRAL1 Gene

Previous GeneCards Identifiers for NMRAL1 Gene

  • GC16M004452
  • GC16M004512

Summaries for NMRAL1 Gene

Entrez Gene Summary for NMRAL1 Gene

  • This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for NMRAL1 Gene

NMRAL1 (NmrA-Like Family Domain Containing 1) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Viral mRNA Translation. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for NMRAL1 Gene

  • Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMRAL1 Gene

Genomics for NMRAL1 Gene

Regulatory Elements for NMRAL1 Gene

Enhancers for NMRAL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NMRAL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NMRAL1 Gene

Chromosome:
16
Start:
4,461,680 bp from pter
End:
4,495,763 bp from pter
Size:
34,084 bases
Orientation:
Minus strand

Genomic View for NMRAL1 Gene

Genes around NMRAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMRAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMRAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMRAL1 Gene

Proteins for NMRAL1 Gene

  • Protein details for NMRAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBL8-NMRL1_HUMAN
    Recommended name:
    NmrA-like family domain-containing protein 1
    Protein Accession:
    Q9HBL8

    Protein attributes for NMRAL1 Gene

    Size:
    299 amino acids
    Molecular mass:
    33344 Da
    Quaternary structure:
    • Homodimer. Interacts with ASS1. Interaction is enhanced by low NADPH/NADP(+) ratios, which results in inhibition of ASS1 activity.
    Miscellaneous:
    • Reduced levels of NMRAL1 by RNAi increases nitric oxide production and reduces cell viability. Overexpression of NMRAL1 increases cell viability.

    Three dimensional structures from OCA and Proteopedia for NMRAL1 Gene

neXtProt entry for NMRAL1 Gene

Proteomics data for NMRAL1 Gene at MOPED

Post-translational modifications for NMRAL1 Gene

  • Ubiquitination at Lys 31, Lys 133, Lys 167, Lys 206, Lys 230, Lys 248, and Lys 281
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NMRAL1 Gene

Domains & Families for NMRAL1 Gene

Gene Families for NMRAL1 Gene

Protein Domains for NMRAL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NMRAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBL8

UniProtKB/Swiss-Prot:

NMRL1_HUMAN :
  • Belongs to the NmrA-type oxidoreductase family.
Family:
  • Belongs to the NmrA-type oxidoreductase family.
genes like me logo Genes that share domains with NMRAL1: view

Function for NMRAL1 Gene

Molecular function for NMRAL1 Gene

UniProtKB/Swiss-Prot Function:
Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
UniProtKB/Swiss-Prot Induction:
By nitric oxide, cGMP and proinflammatory cytokines.
genes like me logo Genes that share phenotypes with NMRAL1: view

Animal Model Products

miRNA for NMRAL1 Gene

miRTarBase miRNAs that target NMRAL1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NMRAL1 Gene

Localization for NMRAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMRAL1 Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMRAL1 Gene COMPARTMENTS Subcellular localization image for NMRAL1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NMRAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with NMRAL1: view

Pathways & Interactions for NMRAL1 Gene

genes like me logo Genes that share pathways with NMRAL1: view

Pathways by source for NMRAL1 Gene

Interacting Proteins for NMRAL1 Gene

Gene Ontology (GO) - Biological Process for NMRAL1 Gene

None

No data available for SIGNOR curated interactions for NMRAL1 Gene

Drugs & Compounds for NMRAL1 Gene

(1) Drugs for NMRAL1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID Experimental Pharma Target 0
genes like me logo Genes that share compounds with NMRAL1: view

Transcripts for NMRAL1 Gene

Unigene Clusters for NMRAL1 Gene

NmrA-like family domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NMRAL1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: -
SP11: - -
SP12: - - - - - -

ExUns: 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for NMRAL1 Gene

GeneLoc Exon Structure for
NMRAL1
ECgene alternative splicing isoforms for
NMRAL1

Expression for NMRAL1 Gene

mRNA expression in normal human tissues for NMRAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NMRAL1 Gene

This gene is overexpressed in Bone (32.0) and Lung (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NMRAL1 Gene



SOURCE GeneReport for Unigene cluster for NMRAL1 Gene Hs.288969

genes like me logo Genes that share expression patterns with NMRAL1: view

Protein tissue co-expression partners for NMRAL1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NMRAL1 Gene

Orthologs for NMRAL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMRAL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NMRAL1 35
  • 87.95 (n)
  • 86.49 (a)
NMRAL1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMRAL1 35
  • 86.96 (n)
  • 87.76 (a)
-- 36
  • 67 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nmral1 35
  • 81.83 (n)
  • 84.95 (a)
Nmral1 16
Nmral1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NMRAL1 35
  • 96.87 (n)
  • 96.31 (a)
NMRAL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmral1 35
  • 81.98 (n)
  • 86.49 (a)
oppossum
(Monodelphis domestica)
Mammalia NMRAL1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMRAL1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMRAL1 35
  • 70.72 (n)
  • 64.86 (a)
NMRAL1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6029 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.9998 35
Species with no ortholog for NMRAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NMRAL1 Gene

ENSEMBL:
Gene Tree for NMRAL1 (if available)
TreeFam:
Gene Tree for NMRAL1 (if available)

Paralogs for NMRAL1 Gene

(1) SIMAP similar genes for NMRAL1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for NMRAL1 Gene

genes like me logo Genes that share paralogs with NMRAL1: view

No data available for Paralogs for NMRAL1 Gene

Variants for NMRAL1 Gene

Sequence variations from dbSNP and Humsavar for NMRAL1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11557236 - 4,469,438(-) CCGCA(C/T)ACTCC intron-variant, reference, missense, utr-variant-5-prime
rs3747582 - 4,461,925(+) CACCG(A/G)GAAAG reference, missense
rs4424915 -- 4,468,391(+) tgggc(A/G)gatca intron-variant
rs13330453 -- 4,462,554(+) AGAGA(A/C)CTGCC intron-variant
rs13330681 -- 4,464,943(+) TGCTC(C/T)GTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMRAL1 Gene

Variant ID Type Subtype PubMed ID
nsv905224 CNV Loss 21882294
esv23732 CNV Gain 19812545
nsv833132 CNV Loss 17160897

Variation tolerance for NMRAL1 Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.93; 67.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NMRAL1 Gene

Disorders for NMRAL1 Gene

Relevant External Links for NMRAL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMRAL1

No disorders were found for NMRAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMRAL1 Gene

Publications for NMRAL1 Gene

  1. NADPH is an allosteric regulator of HSCARG. (PMID: 19254724) Dai X. … Zheng X. (J. Mol. Biol. 2009) 3 4 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation. (PMID: 24711370) Hu B. … Zheng X. (Nucleic Acids Res. 2014) 3

Products for NMRAL1 Gene

Sources for NMRAL1 Gene

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