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Aliases for NMRAL1 Gene

Aliases for NMRAL1 Gene

  • NmrA-Like Family Domain Containing 1 2 3
  • HSCARG 3 4
  • Short Chain Dehydrogenase/Reductase Family 48A, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 48A 2
  • NmrA-Like Family Domain-Containing Protein 1 3
  • Member 1 2
  • SDR48A1 3

External Ids for NMRAL1 Gene

Previous GeneCards Identifiers for NMRAL1 Gene

  • GC16M004452
  • GC16M004512

Summaries for NMRAL1 Gene

Entrez Gene Summary for NMRAL1 Gene

  • This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for NMRAL1 Gene

NMRAL1 (NmrA-Like Family Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NMRAL1 Gene

  • Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMRAL1 Gene

Genomics for NMRAL1 Gene

Regulatory Elements for NMRAL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NMRAL1 Gene

Start:
4,461,680 bp from pter
End:
4,495,763 bp from pter
Size:
34,084 bases
Orientation:
Minus strand

Genomic View for NMRAL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NMRAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMRAL1 Gene

Proteins for NMRAL1 Gene

  • Protein details for NMRAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBL8-NMRL1_HUMAN
    Recommended name:
    NmrA-like family domain-containing protein 1
    Protein Accession:
    Q9HBL8
    Secondary Accessions:

    Protein attributes for NMRAL1 Gene

    Size:
    299 amino acids
    Molecular mass:
    33344 Da
    Quaternary structure:
    • Homodimer. Interacts with ASS1. Interaction is enhanced by low NADPH/NADP(+) ratios, which results in inhibition of ASS1 activity.
    Miscellaneous:
    • Reduced levels of NMRAL1 by RNAi increases nitric oxide production and reduces cell viability. Overexpression of NMRAL1 increases cell viability

    Three dimensional structures from OCA and Proteopedia for NMRAL1 Gene

neXtProt entry for NMRAL1 Gene

Proteomics data for NMRAL1 Gene at MOPED

Post-translational modifications for NMRAL1 Gene

  • Ubiquitination at Lys31, Lys133, Lys167, Lys206, Lys230, Lys248, and Lys281
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NMRAL1 Gene

Domains for NMRAL1 Gene

Gene Families for NMRAL1 Gene

HGNC:
  • SDRA :Short chain dehydrogenase/reductase superfamily / Atypical members

Protein Domains for NMRAL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NMRAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBL8

UniProtKB/Swiss-Prot:

NMRL1_HUMAN :
  • Q9HBL8
Family:
  • Belongs to the NmrA-type oxidoreductase family.
genes like me logo Genes that share domains with NMRAL1: view

Function for NMRAL1 Gene

Molecular function for NMRAL1 Gene

UniProtKB/Swiss-Prot Function:
Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
UniProtKB/Swiss-Prot Induction:
By nitric oxide, cGMP and proinflammatory cytokines.

Gene Ontology (GO) - Molecular Function for NMRAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with NMRAL1: view

Phenotypes for NMRAL1 Gene

genes like me logo Genes that share phenotypes with NMRAL1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NMRAL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NMRAL1 Gene

Localization for NMRAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMRAL1 Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMRAL1 Gene COMPARTMENTS Subcellular localization image for NMRAL1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NMRAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with NMRAL1: view

Pathways for NMRAL1 Gene

SuperPathways for NMRAL1 Gene

No Data Available

Interacting Proteins for NMRAL1 Gene

Gene Ontology (GO) - Biological Process for NMRAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with NMRAL1: view

No data available for Pathways by source for NMRAL1 Gene

Compounds for NMRAL1 Gene

(1) Drugbank Compounds for NMRAL1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID
target
genes like me logo Genes that share compounds with NMRAL1: view

Transcripts for NMRAL1 Gene

Unigene Clusters for NMRAL1 Gene

NmrA-like family domain containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NMRAL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMRAL1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: -
SP11: - -
SP12: - - - - - -

ExUns: 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for NMRAL1 Gene

GeneLoc Exon Structure for
NMRAL1
ECgene alternative splicing isoforms for
NMRAL1

Expression for NMRAL1 Gene

mRNA expression in normal human tissues for NMRAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NMRAL1 Gene

This gene is overexpressed in Bone (32.0) and Lung (13.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NMRAL1 Gene

SOURCE GeneReport for Unigene cluster for NMRAL1 Gene Hs.288969

genes like me logo Genes that share expressions with NMRAL1: view

Expression partners for NMRAL1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NMRAL1 Gene

Orthologs for NMRAL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMRAL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NMRAL1 35
  • 87.95 (n)
  • 86.49 (a)
NMRAL1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMRAL1 35
  • 86.96 (n)
  • 87.76 (a)
-- 36
  • 67 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nmral1 35
  • 81.83 (n)
  • 84.95 (a)
Nmral1 16
Nmral1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NMRAL1 35
  • 96.87 (n)
  • 96.31 (a)
NMRAL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmral1 35
  • 81.98 (n)
  • 86.49 (a)
oppossum
(Monodelphis domestica)
Mammalia NMRAL1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMRAL1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMRAL1 35
  • 70.72 (n)
  • 64.86 (a)
NMRAL1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6029 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.9998 35
Species with no ortholog for NMRAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NMRAL1 Gene

ENSEMBL:
Gene Tree for NMRAL1 (if available)
TreeFam:
Gene Tree for NMRAL1 (if available)

Paralogs for NMRAL1 Gene

Selected SIMAP similar genes for NMRAL1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for NMRAL1 Gene

genes like me logo Genes that share paralogs with NMRAL1: view

No data available for Paralogs for NMRAL1 Gene

Variants for NMRAL1 Gene

Sequence variations from dbSNP and Humsavar for NMRAL1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1043380 -- 4,461,891(-) CGTTT(C/T)TATGC reference, synonymous-codon
rs1133449 -- 4,466,387(-) TCGCT(C/G)ATCTG missense, reference
rs1139640 -- 4,466,380(-) TCTGG(A/C)CAGGC missense, reference
rs1898737 -- 4,468,204(+) ggctg(A/G)ggcag intron-variant
rs3747582 - 4,461,925(+) CACCG(A/G)GAAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NMRAL1 Gene

Variant ID Type Subtype PubMed ID
nsv905224 CNV Loss 21882294
esv23732 CNV Gain 19812545
nsv833132 CNV Loss 17160897

Relevant External Links for NMRAL1 Gene

HapMap Linkage Disequilibrium report
NMRAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMRAL1 Gene

Disorders for NMRAL1 Gene

No disorders were found for NMRAL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NMRAL1 Gene

Publications for NMRAL1 Gene

  1. An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. (PMID: 18263583) Zhao Y. … Zheng X. (J. Biol. Chem. 2008) 3 4
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. NADPH is an allosteric regulator of HSCARG. (PMID: 19254724) Dai X. … Zheng X. (J. Mol. Biol. 2009) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4

Products for NMRAL1 Gene

Sources for NMRAL1 Gene

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