Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NMNAT3 Gene

Aliases for NMNAT3 Gene

  • Nicotinamide Nucleotide Adenylyltransferase 3 2 3 5
  • Nicotinamide-Nucleotide Adenylyltransferase 3 3 4
  • Nicotinate-Nucleotide Adenylyltransferase 3 3 4
  • Pyridine Nucleotide Adenylyltransferase 3 3 4
  • NMN/NaMN Adenylyltransferase 3 3 4
  • NaMN Adenylyltransferase 3 3 4
  • NMN Adenylyltransferase 3 3 4
  • PNAT-3 3 4
  • Nicotinamide Mononucleotide Adenylyltransferase 3 3
  • EC 2.7.7.18 4
  • EC 2.7.7.1 4
  • FKSG76 3
  • PNAT3 3

External Ids for NMNAT3 Gene

Previous GeneCards Identifiers for NMNAT3 Gene

  • GC03U900263
  • GC03M140599
  • GC03M140761
  • GC03M139279
  • GC03M136654

Summaries for NMNAT3 Gene

Entrez Gene Summary for NMNAT3 Gene

  • This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for NMNAT3 Gene

NMNAT3 (Nicotinamide Nucleotide Adenylyltransferase 3) is a Protein Coding gene. Among its related pathways are Metabolism and Tryptophan metabolism. GO annotations related to this gene include nucleotidyltransferase activity and nicotinamide-nucleotide adenylyltransferase activity. An important paralog of this gene is NMNAT2.

UniProtKB/Swiss-Prot for NMNAT3 Gene

  • Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMNAT3 Gene

Genomics for NMNAT3 Gene

Regulatory Elements for NMNAT3 Gene

Promoters for NMNAT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NMNAT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NMNAT3 Gene

Chromosome:
3
Start:
139,560,180 bp from pter
End:
139,678,043 bp from pter
Size:
117,864 bases
Orientation:
Minus strand

Genomic View for NMNAT3 Gene

Genes around NMNAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMNAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMNAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMNAT3 Gene

Proteins for NMNAT3 Gene

  • Protein details for NMNAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T66-NMNA3_HUMAN
    Recommended name:
    Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
    Protein Accession:
    Q96T66
    Secondary Accessions:
    • B3KVR6
    • D3DNF2
    • D3DNF3
    • Q8N4G1

    Protein attributes for NMNAT3 Gene

    Size:
    252 amino acids
    Molecular mass:
    28322 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for NMNAT3 Gene

    Alternative splice isoforms for NMNAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NMNAT3 Gene

Proteomics data for NMNAT3 Gene at MOPED

Post-translational modifications for NMNAT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NMNAT3 Gene

Domains & Families for NMNAT3 Gene

Protein Domains for NMNAT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96T66

UniProtKB/Swiss-Prot:

NMNA3_HUMAN :
  • Belongs to the eukaryotic NMN adenylyltransferase family.
Family:
  • Belongs to the eukaryotic NMN adenylyltransferase family.
genes like me logo Genes that share domains with NMNAT3: view

No data available for Gene Families for NMNAT3 Gene

Function for NMNAT3 Gene

Molecular function for NMNAT3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=209 uM for NMN {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=130 uM for NAD(+) {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=29 uM for ATP {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=390 uM for PPi {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=276 uM for GTP {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=350 uM for ITP {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=111 uM for NaMN {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=130 uM for NMNH {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=2.01 uM for triazofurin monophosphate {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; Vmax=3.6 umol/min/mg enzyme for NAD synthesis {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; Vmax=12.8 umol/min/mg enzyme for pyrophosphorolytic NAD(+) cleavage {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; Vmax=2.9 umol/min/mg enzyme for pyrophosphorolytic NADH cleavage {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nicotinamide ribonucleotide = diphosphate + NAD(+).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+).
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5)-P4-(nicotinic-acid-riboside-5)-tetraphosphate (Nap4AD).
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.

Enzyme Numbers (IUBMB) for NMNAT3 Gene

Gene Ontology (GO) - Molecular Function for NMNAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with NMNAT3: view
genes like me logo Genes that share phenotypes with NMNAT3: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NMNAT3 Gene

Localization for NMNAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMNAT3 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMNAT3 Gene COMPARTMENTS Subcellular localization image for NMNAT3 gene
Compartment Confidence
cytosol 5
mitochondrion 5
golgi apparatus 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for NMNAT3 Gene

Pathways & Interactions for NMNAT3 Gene

genes like me logo Genes that share pathways with NMNAT3: view

UniProtKB/Swiss-Prot Q96T66-NMNA3_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.
  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.

Interacting Proteins for NMNAT3 Gene

Gene Ontology (GO) - Biological Process for NMNAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009058 biosynthetic process IEA --
GO:0009611 response to wounding IEA --
GO:0019674 NAD metabolic process TAS --
genes like me logo Genes that share ontologies with NMNAT3: view

No data available for SIGNOR curated interactions for NMNAT3 Gene

Drugs & Compounds for NMNAT3 Gene

(7) Drugs for NMNAT3 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Alpha,Beta-Methyleneadenosine-5'-Triphosphate Experimental Pharma Target 0
Deamido-Nad+ Experimental Pharma Target 0
nicotinamide mononucleotide Experimental Pharma Target 0
Diphosphate Experimental Pharma 0

(7) Additional Compounds for NMNAT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-nicotinamide D-ribonucleotide
Delphinidin 3-rhamnoside 5-glucoside
  • Delphinidin 5-glucoside 3-rhamnoside
53925-31-8
Nicotinamide ribotide
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium hydroxide inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium hydroxide inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium inner salt
  • 3-Carbamoyl-1-b-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
1094-61-7
nicotinate beta-D-ribonucleotide
Nicotinic acid adenine dinucleotide
  • Deamido-NAD+
  • Deamidonicotinamide adenine dinucleoetide
  • Deamino-nad+
  • NAAD
  • NaADN
6450-77-7
genes like me logo Genes that share compounds with NMNAT3: view

Transcripts for NMNAT3 Gene

Unigene Clusters for NMNAT3 Gene

Nicotinamide nucleotide adenylyltransferase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NMNAT3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6:

Relevant External Links for NMNAT3 Gene

GeneLoc Exon Structure for
NMNAT3
ECgene alternative splicing isoforms for
NMNAT3

Expression for NMNAT3 Gene

mRNA expression in normal human tissues for NMNAT3 Gene

Protein differential expression in normal tissues from HIPED for NMNAT3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.4), Salivary gland (8.5), and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NMNAT3 Gene



SOURCE GeneReport for Unigene cluster for NMNAT3 Gene Hs.208673

mRNA Expression by UniProt/SwissProt for NMNAT3 Gene

Q96T66-NMNA3_HUMAN
Tissue specificity: Expressed in lung and spleen with lower levels in placenta and kidney.
genes like me logo Genes that share expression patterns with NMNAT3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for NMNAT3 Gene

Orthologs for NMNAT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NMNAT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMNAT3 35
  • 98.91 (n)
  • 99.07 (a)
NMNAT3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DTWD1 35
NMNAT3 36
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMNAT3 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmnat3 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMNAT3 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMNAT3 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMNAT3 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMNAT3 36
  • 27 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii NMNAT3 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nmnat 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMA1 36
  • 18 (a)
ManyToMany
NMA2 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
Species with no ortholog for NMNAT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMNAT3 Gene

ENSEMBL:
Gene Tree for NMNAT3 (if available)
TreeFam:
Gene Tree for NMNAT3 (if available)

Paralogs for NMNAT3 Gene

Paralogs for NMNAT3 Gene

(2) SIMAP similar genes for NMNAT3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NMNAT3: view

Variants for NMNAT3 Gene

Sequence variations from dbSNP and Humsavar for NMNAT3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs499787 -- 139,672,686(-) CCAGA(G/T)ATGAG intron-variant
rs578442 -- 139,620,693(+) atcat(A/G)cagta intron-variant
rs504808 -- 139,672,440(-) CCTCT(C/T)GAAAG intron-variant
rs514819 -- 139,616,125(-) TGGCT(C/T)TGTTG intron-variant
rs562337 -- 139,649,538(+) TTTGA(A/G)CACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMNAT3 Gene

Variant ID Type Subtype PubMed ID
nsv877543 CNV Gain 21882294

Variation tolerance for NMNAT3 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMNAT3 Gene

HapMap Linkage Disequilibrium report
NMNAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMNAT3 Gene

Disorders for NMNAT3 Gene

Relevant External Links for NMNAT3

Genetic Association Database (GAD)
NMNAT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMNAT3

No disorders were found for NMNAT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMNAT3 Gene

Publications for NMNAT3 Gene

  1. Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis. (PMID: 12574164) Zhang X. … Zhang H. (J. Biol. Chem. 2003) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Insight into molecular and functional properties of NMNAT3 reveals new hints of NAD homeostasis within human mitochondria. (PMID: 24155910) Felici R. … Chiarugi A. (PLoS ONE 2013) 3

Products for NMNAT3 Gene

Sources for NMNAT3 Gene

Back to Top

Content