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Aliases for NMNAT3 Gene

Aliases for NMNAT3 Gene

  • Nicotinamide Nucleotide Adenylyltransferase 3 2 3
  • Nicotinamide-Nucleotide Adenylyltransferase 3 3 4
  • Nicotinate-Nucleotide Adenylyltransferase 3 3 4
  • Pyridine Nucleotide Adenylyltransferase 3 3 4
  • NMN/NaMN Adenylyltransferase 3 3 4
  • NaMN Adenylyltransferase 3 3 4
  • NMN Adenylyltransferase 3 3 4
  • PNAT-3 3 4
  • PNAT3 3 6
  • Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 3 3
  • Nicotinamide Mononucleotide Adenylyltransferase 3 3
  • EC 2.7.7.18 4
  • EC 2.7.7.1 4
  • FKSG76 3

External Ids for NMNAT3 Gene

Previous GeneCards Identifiers for NMNAT3 Gene

  • GC03U900263
  • GC03M140599
  • GC03M140761
  • GC03M139279
  • GC03M136654

Summaries for NMNAT3 Gene

Entrez Gene Summary for NMNAT3 Gene

  • This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for NMNAT3 Gene

NMNAT3 (Nicotinamide Nucleotide Adenylyltransferase 3) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include nicotinate-nucleotide adenylyltransferase activity and nicotinamide-nucleotide adenylyltransferase activity. An important paralog of this gene is NMNAT2.

UniProtKB/Swiss-Prot for NMNAT3 Gene

  • Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMNAT3 Gene

Genomics for NMNAT3 Gene

Regulatory Elements for NMNAT3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NMNAT3 Gene

Start:
139,560,180 bp from pter
End:
139,678,043 bp from pter
Size:
117,864 bases
Orientation:
Minus strand

Genomic View for NMNAT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NMNAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMNAT3 Gene

Proteins for NMNAT3 Gene

  • Protein details for NMNAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T66-NMNA3_HUMAN
    Recommended name:
    Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
    Protein Accession:
    Q96T66
    Secondary Accessions:
    • B3KVR6
    • D3DNF2
    • D3DNF3
    • Q8N4G1

    Protein attributes for NMNAT3 Gene

    Size:
    252 amino acids
    Molecular mass:
    28322 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Divalent metal cations. Mg(2+) confers the highest activity.;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for NMNAT3 Gene

    Alternative splice isoforms for NMNAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NMNAT3 Gene

Proteomics data for NMNAT3 Gene at MOPED

Post-translational modifications for NMNAT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NMNAT3 Gene

No data available for DME Specific Peptides for NMNAT3 Gene

Domains for NMNAT3 Gene

Protein Domains for NMNAT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96T66

UniProtKB/Swiss-Prot:

NMNA3_HUMAN :
  • Q96T66
Family:
  • Belongs to the eukaryotic NMN adenylyltransferase family.
genes like me logo Genes that share domains with NMNAT3: view

No data available for Gene Families for NMNAT3 Gene

Function for NMNAT3 Gene

Molecular function for NMNAT3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=209 uM for NMN {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=130 uM for NAD(+) {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=29 uM for ATP {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=390 uM for PPi {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=276 uM for GTP {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=350 uM for ITP {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=111 uM for NaMN {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=130 uM for NMNH {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=2.01 uM for triazofurin monophosphate {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; Vmax=3.6 umol/min/mg enzyme for NAD synthesis {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; Vmax=12.8 umol/min/mg enzyme for pyrophosphorolytic NAD(+) cleavage {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; Vmax=2.9 umol/min/mg enzyme for pyrophosphorolytic NADH cleavage {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)
UniProtKB/Swiss-Prot CatalyticActivity: ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+)
UniProtKB/Swiss-Prot EnzymeRegulation: Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5)-P4-(nicotinic-acid-riboside-5)-tetraphosphate (Nap4AD).
UniProtKB/Swiss-Prot Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.

Enzyme Numbers (IUBMB) for NMNAT3 Gene

Gene Ontology (GO) - Molecular Function for NMNAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000309 nicotinamide-nucleotide adenylyltransferase activity TAS --
GO:0003824 catalytic activity --
GO:0004515 nicotinate-nucleotide adenylyltransferase activity IDA 16118205
GO:0005524 ATP binding IEA --
GO:0016779 nucleotidyltransferase activity --
genes like me logo Genes that share ontologies with NMNAT3: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NMNAT3 Gene

Localization for NMNAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMNAT3 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMNAT3 Gene COMPARTMENTS Subcellular localization image for NMNAT3 gene
Compartment Confidence
mitochondrion 5
cytosol 4
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NMNAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 16118205
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NMNAT3: view

Pathways for NMNAT3 Gene

SuperPathways for NMNAT3 Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Nicotinate and nicotinamide metabolism
3 tryptophan utilization II
4 Metabolism
5 Disease
genes like me logo Genes that share pathways with NMNAT3: view

UniProtKB/Swiss-Prot Q96T66-NMNA3_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1
  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1

Interacting Proteins for NMNAT3 Gene

Gene Ontology (GO) - Biological Process for NMNAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0009058 biosynthetic process --
GO:0009435 NAD biosynthetic process IEA --
GO:0009611 response to wounding IEA --
genes like me logo Genes that share ontologies with NMNAT3: view

Compounds for NMNAT3 Gene

(8) HMDB Compounds for NMNAT3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
Nicotinamide ribotide
  • 3-(aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium hydroxide inner salt
1094-61-7
Nicotinic acid adenine dinucleotide
  • NAAD
6450-77-7

(4) Drugbank Compounds for NMNAT3 Gene

genes like me logo Genes that share compounds with NMNAT3: view

Transcripts for NMNAT3 Gene

Unigene Clusters for NMNAT3 Gene

Nicotinamide nucleotide adenylyltransferase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NMNAT3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMNAT3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6:

Relevant External Links for NMNAT3 Gene

GeneLoc Exon Structure for
NMNAT3
ECgene alternative splicing isoforms for
NMNAT3

Expression for NMNAT3 Gene

mRNA expression in normal human tissues for NMNAT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NMNAT3 Gene

SOURCE GeneReport for Unigene cluster for NMNAT3 Gene Hs.208673

mRNA Expression by UniProt/SwissProt for NMNAT3 Gene

Q96T66-NMNA3_HUMAN
Tissue specificity: Expressed in lung and spleen with lower levels in placenta and kidney.
genes like me logo Genes that share expressions with NMNAT3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NMNAT3 Gene

Orthologs for NMNAT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NMNAT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMNAT3 35
  • 98.91 (n)
  • 99.07 (a)
NMNAT3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DTWD1 35
NMNAT3 36
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMNAT3 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmnat3 16
Nmnat3 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMNAT3 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMNAT3 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMNAT3 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMNAT3 36
  • 27 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii NMNAT3 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nmnat 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMA1 36
  • 18 (a)
ManyToMany
NMA2 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
Species with no ortholog for NMNAT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMNAT3 Gene

ENSEMBL:
Gene Tree for NMNAT3 (if available)
TreeFam:
Gene Tree for NMNAT3 (if available)

Paralogs for NMNAT3 Gene

Paralogs for NMNAT3 Gene

Selected SIMAP similar genes for NMNAT3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NMNAT3: view

Variants for NMNAT3 Gene

Sequence variations from dbSNP and Humsavar for NMNAT3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs499787 -- 139,672,686(-) CCAGA(G/T)ATGAG intron-variant, utr-variant-5-prime
rs504808 -- 139,672,440(-) CCTCT(C/T)GAAAG intron-variant
rs514819 -- 139,616,125(-) TGGCT(C/T)TGTTG intron-variant
rs528714 -- 139,649,464(+) GTCTC(A/T)TCTAC intron-variant
rs530251 -- 139,630,947(+) ATACA(A/T)TGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMNAT3 Gene

Variant ID Type Subtype PubMed ID
nsv877543 CNV Gain 21882294

Relevant External Links for NMNAT3 Gene

HapMap Linkage Disequilibrium report
NMNAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMNAT3 Gene

Disorders for NMNAT3 Gene

Relevant External Links for NMNAT3

Genetic Association Database (GAD)
NMNAT3
genes like me logo Genes that share disorders with NMNAT3: view

No data available for UniProtKB/Swiss-Prot for NMNAT3 Gene

Publications for NMNAT3 Gene

  1. Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis. (PMID: 12574164) Zhang X. … Zhang H. (J. Biol. Chem. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. (PMID: 16118205) Berger F. … Ziegler M. (J. Biol. Chem. 2005) 3 4
  4. Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis. (PMID: 17402747) Sorci L. … Magni G. (Biochemistry 2007) 3 4
  5. NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration. (PMID: 18344983) Zhai R.G. … Bellen H.J. (Nature 2008) 3

Products for NMNAT3 Gene

Sources for NMNAT3 Gene

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