NMNAT3 Gene
protein-coding GIFtS: 52
GCID: GC03M139279
|
|
nicotinamide nucleotide adenylyltransferase 3
| |
Aliases
for NMNAT3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nicotinamide Nucleotide Adenylyltransferase 31 2 | | NaMN Adenylyltransferase 32 3 | | PNAT31 2 5 | | NMN Adenylyltransferase 32 3 | | Nicotinate-Nucleotide Adenylyltransferase 32 3 | | Nicotinamide Mononucleotide Adenylyltransferase 32 | | Pyridine Nucleotide Adenylyltransferase 32 3 | | EC 2.7.7.13 | | PNAT-32 3 | | EC 2.7.7.183 |
Export aliases for NMNAT3 gene to outside databasesPrevious GC identifers: GC03U900263 GC03M140599 GC03M140761 GC03M136654 |
Summaries
for NMNAT3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NMNAT3:
This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymesuse ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide fromnicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized tomitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcriptvariants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jan 2011)
UniProtKB/Swiss-Prot: NMNA3_HUMAN, Q96T66Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidatedform; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate(TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. thepyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinicacid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleavephosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury
|
Genomic Views
for NMNAT3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NMNAT3 gene promoter:
E2F-4 E2F-3a E2F-5 NCX/Ncx E2F-2 NF-kappaB PPAR-alpha E2F E2F-1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NMNAT3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMNAT3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q23 Ensembl cytogenetic band: 3q23 HGNC cytogenetic band: 3q23NMNAT3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M139279: view genomic region
(about GC identifiers)
Start:
|
139,279,022 bp from pter |
End:
|
139,396,859 bp from pter |
Size:
|
117,838 bases |
Orientation:
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minus strand |
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Proteins
for NMNAT3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NMNA3_HUMAN, Q96T66 (See
protein sequence)Recommended Name: Nicotinamide mononucleotide adenylyltransferase 3 Size: 252 amino acids; 28322 Da
Cofactor: Divalent metal cations. Magnesium confers the highest activity
Subunit: Homotetramer
Subcellular location: Mitochondrion
6 PDB 3D structures from  and Proteopedia  for NMNAT3:1NUP (3D)
1NUQ (3D)
1NUR (3D)
1NUS (3D)
1NUT (3D)
1NUU (3D)
Secondary accessions: B3KVR6 D3DNF2 D3DNF3 Q8N4G1Alternative splicing: 3 isoforms: Q96T66-1 Q96T66-2 Q96T66-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NMNAT3: NX_Q96T66
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96T66
NMNAT3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001186976.1 NP_835471.1
ENSEMBL proteins: ENSP00000423335 ENSP00000340523 ENSP00000412953 ENSP00000296202 ENSP00000425041 ENSP00000426357 ENSP00000427634 ENSP00000426375 ENSP00000384319 ENSP00000384684 Reactome Protein details: Q96T66
Human Recombinant Protein Products for NMNAT3:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NMNAT3 for ontologies About GeneDecksing
NMNAT3 Antibody Products:
Assay Products for NMNAT3: |
Protein
Domains /
Families
for NMNAT3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NMNAT3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96T66ProtoNet protein and cluster: Q96T66 1 Blocks protein family: IPB004820 Cytidylyltransferase
UniProtKB/Swiss-Prot: NMNA3_HUMAN, Q96T66Similarity: Belongs to the eukaryotic NMN adenylyltransferase family |
Function
for NMNAT3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NMNA3_HUMAN, Q96T66Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidatedform; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate(TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. thepyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinicacid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleavephosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injuryCatalytic activity: ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)Catalytic activity: ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+)Enzyme regulation: Activity is strongly inhibited by galotannin. Inhibited byP1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate (Nap4AD)Biophysicochemical properties: Kinetic parameters: KM=209 uM for NMN; KM=130 uM for NAD(+); KM=29 uM for ATP; KM=390 uMfor PPi; KM=276 uM for GTP; KM=350 uM for ITP; KM=111 uM for NaMN; KM=130 uM for NMNH; KM=2.01 uM for triazofurinmonophosphate; Vmax=3.6 umol/min/mg enzyme for NAD synthesis; Vmax=12.8 umol/min/mg enzyme for pyrophosphorolyticNAD(+) cleavage; Vmax=2.9 umol/min/mg enzyme for pyrophosphorolytic NADH cleavage; Enzyme Numbers (IUBMB): EC 2.7.7.181 EC 2.7.7.11
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000309 | nicotinamide-nucleotide adenylyltransferase activity |
TAS | -- | | GO:0004515 | nicotinate-nucleotide adenylyltransferase activity |
IDA | 16118205 | | GO:0005524 | ATP binding |
IEA | -- | | GO:0016779 | nucleotidyltransferase activity |
-- | -- |
NMNAT3 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NMNAT3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NMNAT3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): NMNAT3 (NM_001200047) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NMNAT3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMNAT3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMNAT3 |
|
Pathways & Interactions
for NMNAT3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nicotinate metabolism | | | 2 | NAD metabolism | | | 3 | Metabolism | | | 4 | Vitamin B5 (pantothenate) metabolism | | | 5 | tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for NMNAT3
1  GeneGo (Thomson Reuters) Pathway for NMNAT3
5  BioSystems Pathways for NMNAT3
4 
Reactome Pathways for NMNAT3
2 
Kegg Pathways (Kegg details for NMNAT3):
UniProtKB/Swiss-Prot: NMNA3_HUMAN, Q96T66Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1
NMNAT3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NMNAT3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/20 Interacting proteins for NMNAT3 (ENSP000003405234) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
NMNAT3 for ontologies About GeneDecksing
|
Drugs & Compounds
for NMNAT3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NMNAT3
8 HMDB Compounds for NMNAT3 About this table
4 DrugBank Compounds for NMNAT3 About this table
Search CenterWatch for drugs/clinical trials and news about NMNAT3 / NMNA3
|
Transcripts
for NMNAT3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NMNAT3 gene (2 alternative transcripts): NM_001200047.1 NM_178177.3 Unigene Cluster for NMNAT3: Nicotinamide nucleotide adenylyltransferase 3 Hs.208673 [show with all ESTs]Unigene Representative Sequence: AK12747716 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000506254(uc003etj.3 uc010hul.3 uc003etk.3 uc003etl.3)
ENST00000339837 ENST00000413939 ENST00000296202 ENST00000511444 ENST00000507242
ENST00000509447 ENST00000512391 ENST00000509291 ENST00000514703 ENST00000505779
ENST00000509737 ENST00000509034 ENST00000511003 ENST00000406164 ENST00000406824
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NMNAT3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NMNAT3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NMNAT3 (NM_001200047) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NMNAT3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMNAT3 |
Additional cDNA sequence: AF345564.1 AK123208.1 AK127477.1 BC034374.1 BC036218.1 BX649063.1 3 DOTS entries: DT.101983519 DT.213011 DT.75176519 24/63 AceView cDNA sequences (see all 63): BC036218 BU192858 BX088743 AF345564 AI142380 AA662455 AA232215 AI002138 AA676739 AK123208 BQ189491 CB068547 BF509120 AW009234 BX649063 BM906198 BI760361 BV201932 AA917773 BF507839 BI964038 BM544763 AW172570 AK127477
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NMNAT3 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for NMNAT3
|
Expression
for NMNAT3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NMNAT3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NMNAT3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NMNAT3
SOURCE GeneReport for Unigene cluster: Hs.208673
UniProtKB/Swiss-Prot: NMNA3_HUMAN, Q96T66Tissue specificity: Expressed in lung and spleen with lower levels in placenta and kidney
SABiosciences Custom PCR Arrays for NMNAT3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NMNAT3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NMNAT3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMNAT3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMNAT3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMNAT3 |
Orthologs
for NMNAT3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NMNAT3 gene from 8/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Nmnat31 , 5 |
nicotinamide nucleotide adenylyltransferase 31, 5 |
83.74(n)1
81.28(a)1 |
|
9 (51.35 cM)5
740801 NM_144533.21 NP_653116.11
982874355 |
chicken
(Gallus gallus) |
Aves |
NMNAT31 |
nicotinamide nucleotide adenylyltransferase 3 |
61.11(n)
60.78(a) |
|
424820 XM_422634.3 XP_422634.3 |
lizard
(Anolis carolinensis) |
Reptilia |
NMNAT36 |
-- |
44(a) |
1 ↔ 1 |
3(27310823-27340417) |
zebrafish
(Danio rerio) |
Actinopterygii |
nmnat31 |
novel protein similar to vertebrate nicotinamide nucleotide more |
59.2(n)
54.23(a) |
|
572070 XM_695734.3 XP_700826.3 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Nmnat1 |
Nicotinamide mononucleotide adenylyltransferase |
53.68(n)
46.67(a) |
|
42987 NM_170185.1 NP_733064.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
W06B3.11 |
Protein W06B3.1 |
48.47(n)
41.38(a) |
|
189236 NM_077609.2 NP_510010.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
NMNAT6 |
nicotinamide mononucleotide adenylyltransferase |
21(a) |
1 → many |
5(22583985-22586347) |
rice
(Oryza sativa) |
Liliopsida |
---- |
cytidylyltransferase domain containing protein, ex...cytidylyltransferase domain containing protein, ex... |
21(a)16(a) |
many ↔ manymany ↔ many |
9(10927395-10929717) 2(34909922-34912117) |
ENSEMBL Gene Tree for NMNAT3 (if available)
TreeFam Gene Tree for NMNAT3 (if available) |
Paralogs
for NMNAT3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NMNAT3 gene
- NMNAT12 NMNAT22
2 SIMAP similar genes for NMNAT3 using alignment to 7 protein entries: NMNA3_HUMAN (see all proteins):NMNAT1 NMNAT2
NMNAT3 for paralogs About GeneDecksing
|
Genomic Variants
for NMNAT3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NMNAT3 (139279022 - 139396859 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NMNAT3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NMNAT3 |
|
Disorders
/ Diseases
for NMNAT3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NMNAT3 for disorders About GeneDecksing
OMIM gene information: 608702
OMIM disorders: --
1  disease for NMNAT3: About MalaCardsneurodegeneration
Export disorders for NMNAT3 gene to outside databases
|
Publications
for NMNAT3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NMNAT3 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with NMNAT3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis. (PubMed id 12574164)1, 2, 3 Zhang X....Zhang H. (2003)
- Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis. (PubMed id 17402747)1, 2 Sorci L.... Magni G. (2007)
- Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. (PubMed id 16118205)1, 2 Berger F.... Ziegler M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Axon degeneration: Mechanisms and implications of a d istinct program from cell death. (PubMed id 20117162)1 Yan T....Zhai Q. (2010)
- Homology modeling and deletion mutants of human nicot inamide mononucleotide adenylyltransferase isozyme 2: new insights on structure and function relationship. (PubMed id 20954240)1 Brunetti L....Magni G. (2010)
- Unique expression pattern of human nicotinamide monon ucleotide adenylyltransferase isozymes in red blood cells. (PubMed id 20457531)1 Di Stefano M....Magni G. (2010)
- Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases. (PubMed id 20388704)1 Lau C....Ziegler M. (2010)
- Nicotinamide/nicotinic acid mononucleotide adenylyltr ansferase, new insights into an ancient enzyme. (PubMed id 19448972)1 Zhai R.G....Garavaglia S. (2009)
- NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration. (PubMed id 18344983)1 Zhai R.G....Bellen H.J. (2008)
|
External Searches for NMNAT3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NMNAT3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NMNAT3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NMNAT3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for NMNAT3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for NMNAT3 gene:
Search GeneIP for patents involving NMNAT3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NMNAT3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NMNAT3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NMNAT3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NMNAT3 | | | OriGene Protein Over-expression Lysate for NMNAT3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NMNAT3 | | OriGene 3'-UTR Clone for NMNAT3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NMNAT3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NMNAT3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NMNAT3 | | OriGene Custom Protein Services for NMNAT3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NMNAT3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NMNAT3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMNAT3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMNAT3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMNAT3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMNAT3 |
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| | | | Search Tocris compounds for NMNAT3 |
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 | | | NMNAT3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMNAT3 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for NMNAT3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMNAT3 |
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