Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NMNAT2 Gene

protein-coding   GIFtS: 61
GCID: GC01M183217

Nicotinamide Nucleotide Adenylyltransferase 2

(Previous name: chromosome 1 open reading frame 15)
(Previous symbol: C1orf15)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nicotinamide Nucleotide Adenylyltransferase 21 2     PNAT22
C1orf151 2 3     Nicotinamide Mononucleotide Adenylyltransferase 22
Nicotinate-Nucleotide Adenylyltransferase 22 3     Pyridine Nucleotide Adenylyltransferase 22
NaMN Adenylyltransferase 22 3     EC 2.7.7.13
NMN Adenylyltransferase 22 3     EC 2.7.7.183
Chromosome 1 Open Reading Frame 151     KIAA04793

External Ids:    HGNC: 167891   Entrez Gene: 230572   Ensembl: ENSG000001570647   OMIM: 6087015   UniProtKB: Q9BZQ43   

Export aliases for NMNAT2 gene to outside databases

Previous GC identifers: GC01M179737 GC01M180456 GC01M179951 GC01M181483 GC01M154453


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NMNAT2 Gene:
This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of
which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which
is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly
expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for NMNAT2 Gene: 
NMNAT2 (nicotinamide nucleotide adenylyltransferase 2) is a protein-coding gene. Diseases associated with NMNAT2 include tauopathy, and prostate cancer, and among its related super-pathways are NAD salvage pathway III and NAD metabolism. GO annotations related to this gene include nicotinamide-nucleotide adenylyltransferase activity and nicotinate-nucleotide adenylyltransferase activity. An important paralog of this gene is NMNAT3.

UniProtKB/Swiss-Prot: NMNA2_HUMAN, Q9BZQ4
Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the
deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use
triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic
cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades
nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated
dinucleotides NADP(+), NADPH and NAADP(+)

Gene Wiki entry for NMNAT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NMNAT2 gene promoter:
         SRF   SRF (504 AA)   GATA-1   CREB   MZF-1   c-Rel   FOXO4   FOXJ2 (long isoform)   FOXJ2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNMNAT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NMNAT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMNAT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

NMNAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMNAT2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M183217:  view genomic region     (about GC identifiers)

Start:
183,217,372 bp from pter      End:
183,387,737 bp from pter
Size:
170,366 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NMNA2_HUMAN, Q9BZQ4 (See protein sequence)
Recommended Name: Nicotinamide mononucleotide adenylyltransferase 2  
Size: 307 amino acids; 34439 Da
Cofactor: Divalent metal cations. Magnesium confers the highest activity
Subunit: Monomer
Subcellular location: Cytoplasm. Golgi apparatus
Sequence caution: Sequence=BAA32324.1; Type=Erroneous initiation;
Secondary accessions: O75067 Q5T1Q3 Q8WU99 Q96QW1
Alternative splicing: 2 isoforms:  Q9BZQ4-1   Q9BZQ4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NMNAT2: NX_Q9BZQ4

Explore proteomics data for NMNAT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BZQ4

  • NMNAT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NMNAT2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_055854.1  NP_733820.1  

    ENSEMBL proteins: 
     ENSP00000294868   ENSP00000287713  
    Reactome Protein details: Q9BZQ4
    Human Recombinant Protein Products for NMNAT2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NMNAT2 (NMNAT-2)
    Enzo Life Sciences proteins for NMNAT2
    OriGene Purified Protein for NMNAT2
    OriGene Protein Over-expression Lysate for NMNAT2
    OriGene MassSpec for NMNAT2 
    OriGene Custom Protein Services for NMNAT2
    GenScript Custom Purified and Recombinant Proteins Services for NMNAT2
    Novus Biologicals NMNAT2 Proteins
    Novus Biologicals NMNAT2 Lysate
    Sino Biological Recombinant Protein for NMNAT2
    Sino Biological Cell Lysate for NMNAT2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NMNAT2 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005770late endosome IEA--
    GO:0005794Golgi apparatus IDA16118205

    NMNAT2 for ontologies           About GeneDecksing



    NMNAT2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NMNAT2
    GenScript Custom Superior Antibodies Services for NMNAT2
    Novus Biologicals NMNAT2 Antibodies
    Abcam antibodies for NMNAT2
    Cloud-Clone Corp. Antibodies for NMNAT2 
    Search ThermoFisher Antibodies for NMNAT2
    LSBio Antibodies in human, mouse, rat for NMNAT2 

    Assay Products for NMNAT2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NMNAT2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NMNAT2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NMNAT2 
    Cloud-Clone Corp. CLIAs for NMNAT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR004821 Cyt_trans-like
     IPR005248 NAMN_adtrnsfrase
     IPR014729 Rossmann-like_a/b/a_fold

    Graphical View of Domain Structure for InterPro Entry Q9BZQ4

    ProtoNet protein and cluster: Q9BZQ4

    1 Blocks protein domain: IPB004820 Cytidylyltransferase

    UniProtKB/Swiss-Prot: NMNA2_HUMAN, Q9BZQ4
    Similarity: Belongs to the eukaryotic NMN adenylyltransferase family


    NMNAT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMNA2_HUMAN, Q9BZQ4
    Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the
    deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use
    triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic
    cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades
    nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated
    dinucleotides NADP(+), NADPH and NAADP(+)
    Catalytic activity: ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)
    Catalytic activity: ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+)
    Enzyme regulation: Inhibited by P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate (Np3AD) and
    P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate (Np4AD)
    Biophysicochemical properties: Kinetic parameters: KM=32 uM for NMN; KM=70 uM for NAD(+); KM=204 uM for ATP;
    KM=1119 uM for PPi; KM=14.5 uM for NaMN; KM=304 uM for NMNH; Vmax=1.1 umol/min/mg enzyme for NAD synthesis;
    Vmax=3 umol/min/mg enzyme for pyrophosphorolytic NAD(+) cleavage; Vmax=7 umol/min/mg enzyme for
    pyrophosphorolytic NADH cleavage; Note=KM is >100 uM for triazofurin monophosphate; pH dependence: Optimum pH is
    6.0-9.0;

         Enzyme Numbers (IUBMB): EC 2.7.7.181 EC 2.7.7.11

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000309nicotinamide-nucleotide adenylyltransferase activity TAS--
    GO:0003824catalytic activity ----
    GO:0004515nicotinate-nucleotide adenylyltransferase activity IDA16118205
    GO:0005524ATP binding IEA--
         
    NMNAT2 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nmnat2):
     behavior/neurological  growth/size  mortality/aging  muscle  nervous system 
     renal/urinary system  respiratory system 

    NMNAT2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NMNAT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NMNAT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NMNAT2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NMNAT2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NMNAT2
    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate NMNAT2 (see all 97):
    hsa-miR-26a-2* hsa-miR-3938 hsa-miR-15a hsa-miR-3921 hsa-miR-3916 hsa-miR-629* hsa-miR-4325 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NMNAT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMNAT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NMNAT2
    Sirion Biotech Customized adenovirus for overexpression of NMNAT2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NMNAT2 (see all 13)
    OriGene ORF clones in mouse, rat for NMNAT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NMNAT2 (NM_015039)
    Sino Biological Human cDNA Clone for NMNAT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMNAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMNAT2
    Sirion Biotech Customized lentivirus for stable overexpression of NMNAT2 
                         Customized lentivirus expression plasmids for stable overexpression of NMNAT2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NMNAT2
    Search LifeMap BioReagents cell lines for NMNAT2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMNAT2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NMNAT2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nicotinate metabolism
    Nicotinate metabolism0.62
    NAD biosynthesis III0.50
    NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde0.62
    NAD salvage pathway II0.42
    NAD salvage pathway III0.50
    2NAD metabolism
    NAD metabolism0.43
    Nicotinate and nicotinamide metabolism0.43
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4tryptophan utilization II
    tryptophan utilization II0.70
    tryptophan utilization I0.70
    5Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors1.00
    Metabolism of vitamins and cofactors1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NMNAT2
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for NMNAT2
        NAD metabolism

    5/7 BioSystems Pathways for NMNAT2 (see all 7)
        NAD salvage pathway III
    NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde
    NAD biosynthesis II (from tryptophan)
    NAD biosynthesis III
    NAD salvage pathway II


    4        Reactome Pathways for NMNAT2
        Nicotinate metabolism
    Metabolism
    Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors


    2         Kegg Pathways  (Kegg details for NMNAT2):
        Nicotinate and nicotinamide metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: NMNA2_HUMAN, Q9BZQ4
    Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1


    NMNAT2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NMNAT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/20 Interacting proteins for NMNAT2 (ENSP000002877134) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD38ENSP000002262794STRING: ENSP00000226279
    ENPP1ENSP000003542384STRING: ENSP00000354238
    ENPP3ENSP000003502654STRING: ENSP00000350265
    NADKENSP000003416794STRING: ENSP00000341679
    NADSYN1ENSP000003264244STRING: ENSP00000326424
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0009058biosynthetic process ----
    GO:0009435NAD biosynthetic process IEA--
    GO:0019674NAD metabolic process TAS--

    NMNAT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NMNAT2 (NMNA2)

    9 HMDB Compounds for NMNAT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Nicotinamide ribotide3-(aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium hydroxide inner salt (see all 15)1094-61-7--
    Nicotinic acid adenine dinucleotideNAAD (see all 9)6450-77-7--
    Nicotinic acid mononucleotide3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt (see all 23)321-02-8--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about NMNAT2 / NMNA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NMNAT2 gene (2 alternative transcripts): 
    NM_015039.3  NM_170706.3  

    Unigene Cluster for NMNAT2:

    Nicotinamide nucleotide adenylyltransferase 2
    Hs.497123  [show with all ESTs]
    Unigene Representative Sequence: AF288395
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294868(uc009wye.2 uc001gqb.2) ENST00000287713(uc001gqc.2)
    ENST00000464047 ENST00000473046(uc001gqd.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NMNAT2
    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate NMNAT2 (see all 97):
    hsa-miR-26a-2* hsa-miR-3938 hsa-miR-15a hsa-miR-3921 hsa-miR-3916 hsa-miR-629* hsa-miR-4325 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NMNAT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMNAT2
    Clone
    Products:
         
    OriGene clones in human, mouse for NMNAT2 (see all 13)
    OriGene ORF clones in mouse, rat for NMNAT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NMNAT2 (NM_015039)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMNAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMNAT2
    Sirion Biotech Customized lentivirus for stable overexpression of NMNAT2 
                         Customized lentivirus expression plasmids for stable overexpression of NMNAT2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NMNAT2
    OriGene qSTAR qPCR primer pairs in human, mouse for NMNAT2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NMNAT2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMNAT2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMNAT2

    Additional mRNA sequence: 

    AB007948.1 AF086038.1 AF288395.1 AK291390.1 AK309461.1 BC016726.1 BC020998.2 BC037251.1 

    12 DOTS entries:

    DT.109124  DT.92052193  DT.92469980  DT.100741669  DT.100767485  DT.95210593  DT.100684051  DT.95286302 
    DT.121423733  DT.95156124  DT.97781868  DT.121423718 

    24/71 AceView cDNA sequences (see all 71):

    AL044819 AI656857 CF529788 AL542337 BC016726 AA984639 AL522207 AA976626 
    CB960361 CA446952 NM_015039 AA984667 BC037251 BG056366 AI989612 NM_170706 
    BC020998 BI493003 CB125294 AI337424 BI832335 AA084243 CB153487 AW071638 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NMNAT2 expression in normal human tissues (normalized intensities)      NMNAT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAAGAGTT
    NMNAT2 Expression
    About this image


    NMNAT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 25 entries
             Cerebral Cortex
             postcentral gyrus   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Eye (Sensory Organs)
             Retina
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See NMNAT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NMNAT2

    SOURCE GeneReport for Unigene cluster: Hs.497123

    UniProtKB/Swiss-Prot: NMNA2_HUMAN, Q9BZQ4
    Tissue specificity: Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal
    lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans

        SABiosciences Custom PCR Arrays for NMNAT2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NMNAT2
    OriGene qSTAR qPCR primer pairs in human, mouse for NMNAT2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NMNAT2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMNAT2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMNAT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMNAT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NMNAT2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nmnat21 , 5 nicotinamide nucleotide adenylyltransferase 21, 5 92.29(n)1
    98.7(a)1
      1 (65.15 cM)5
    2265181  NM_175460.31  NP_780669.11 
     1529551015 
    chicken
    (Gallus gallus)
    Aves NMNAT21 nicotinamide nucleotide adenylyltransferase 2 85.45(n)
    93.49(a)
      771393  XM_001234669.2  XP_001234670.1 
    lizard
    (Anolis carolinensis)
    Reptilia NMNAT26
    nicotinamide nucleotide adenylyltransferase 2
    94(a)
    1 ↔ 1
    GL343203.1(4205981-4316023)
    zebrafish
    (Danio rerio)
    Actinopterygii BC059430.12   -- 80.22(n)   336257  BC059430.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nmat-16
    nmat-26
    Uncharacterized protein F26H9.4
    36(a)
    34(a)
    1 ↔ many
    1 ↔ many
    X(12014254-12016176)
    I(9305750-9306846)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NMA26
    NMA16
    Nicotinic acid mononucleotide adenylyltransferase,...
    Nicotinic acid mononucleotide adenylyltransferase,...
    22(a)
    21(a)
    many ↔ many
    many ↔ many
    VII(511545-512732)
    XII(784913-786118)


    ENSEMBL Gene Tree for NMNAT2 (if available)
    TreeFam Gene Tree for NMNAT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NMNAT2 gene
    NMNAT32  NMNAT12  
    2 SIMAP similar genes for NMNAT2 using alignment to 1 protein entry:     NMNA2_HUMAN:
    NMNAT1    NMNAT3

    NMNAT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3784 SNPs in NMNAT2 are shown (see all 3784)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492508061,2
    Cuntested1183255921(+) GTCACA/C/TCTCTA 4 R S mis11NA 4548
    rs571698491,2
    C--154615345(+) AAAAA-/A/AA  
            
    TAGCC
    1 -- int11NA 2
    rs616347811,2
    C,F--183216981(+) AAGTTC/TTGTTT 2 -- ds50014Minor allele frequency- T:0.15WA CSA 124
    rs1863561771,2
    --183217004(+) TTCAAA/GCTAAA 2 -- ds50010--------
    rs1427305201,2
    --183217042(+) AATATA/CATTTT 2 -- ds50010--------
    rs1910983331,2
    --183217111(+) AATTAA/GTCAAG 2 -- ds50010--------
    rs755371891,2
    F--183217216(+) ACATAC/ATTTTA 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1832585031,2
    C--183217222(+) TTTTAC/TATAAC 2 -- ds50010--------
    rs5018791,2
    C,F,O,H--183217278(-) GTAAAA/GATGTA 2 -- ds500197Minor allele frequency- G:0.03EA NA NS PA EU CA WA CSA 5430
    rs1998707641,2
    C--183217353(+) AAGTTC/GTTGAC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for NMNAT2 (183217372 - 183387737 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NMNAT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2720128CNV Deletion23290073
    esv2660635CNV Deletion23128226
    esv2720117CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NMNAT2
    DNA2.0 Custom Variant and Variant Library Synthesis for NMNAT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608701    OMIM disorders: --

    3 diseases for NMNAT2:    About MalaCards
    tauopathy    prostate cancer    prostatitis


    NMNAT2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NMNAT2
    Human Genome Epidemiology (HuGE) Navigator: NMNAT2 (2 documents)

    Export disorders for NMNAT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NMNAT2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with NMNAT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel human nicotinamide mononucleotide adenylyltransferase. (PubMed id 12359228)1, 2, 3 Raffaelli N.... Magni G. (2002)
    2. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PubMed id 11318611)1, 2, 3 Sood R....Carpten J.D. (2001)
    3. Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas. (PubMed id 14516279)1, 2, 9 Yalowitz J.A.... Jayaram H.N. (2004)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. A targeted association study in systemic lupus erythe matosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (2010)
    6. Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis. (PubMed id 17402747)1, 2 Sorci L.... Magni G. (2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. (PubMed id 16118205)1, 2 Berger F.... Ziegler M. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23057 HGNC: 16789 AceView: NMNAT2 Ensembl:ENSG00000157064 euGenes: HUgn23057
    ECgene: NMNAT2 Kegg: 23057 H-InvDB: NMNAT2

    (According to HUGE)
    About This Section
    HUGE: KIAA0479

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NMNAT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NMNAT2 gene:
    Search GeneIP for patents involving NMNAT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for NMNAT2 (NMNAT-2)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NMNAT2  
     OriGene qPCR primer pairs and template standards for NMNAT2   OriGene Protein Over-expression Lysate for NMNAT2  
     OriGene MassSpec something-or-other for NMNAT2   OriGene clones in human, mouse for NMNAT2  
     OriGene qSTAR qPCR primer pairs in human, mouse for NMNAT2   OriGene Purified Protein for NMNAT2  
     OriGene ORF clones in mouse, rat for NMNAT2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NMNAT2   OriGene Custom Protein Services for NMNAT2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NMNAT2
     QIAGEN SeqTarget long-range PCR primers for resequencing NMNAT2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMNAT2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMNAT2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMNAT2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMNAT2
     GenScript Custom Purified and Recombinant Proteins Services for NMNAT2 GenScript cDNA clones with any tag delivered in your preferred vector for NMNAT2
     GenScript Custom Assay Services for NMNAT2 GenScript Custom Superior Antibodies Services for NMNAT2
     GenScript Custom overexpressing Cell Line Services for NMNAT2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NMNAT2 promoter
     Search Chromatin IP Primers for NMNAT2
     RT2 qPCR Primer Assay in human, mouse, rat NMNAT2
     Search GNC Networks for NMNAT2
     SABiosciences Custom PCR Arrays for NMNAT2
     Search Tocris compounds for NMNAT2 (NMNA2)
     Proteins and Antibodies for NMNAT2
     Cell Lysates for NMNAT2
     cDNA Clones for NMNAT2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for NMNAT2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NMNAT2 antibodies
     NMNAT2 proteins
     NMNAT2 lysates
     Antibodies for NMNAT2
     See all of Abcam's Antibodies, Kits and Proteins for NMNAT2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NMNAT2
     Antibodies for NMNAT2
     ELISAs for NMNAT2
     CLIAs for NMNAT2
     Search LifeMap BioReagents cell lines for NMNAT2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMNAT2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NMNAT2
     SwitchGear Promoter luciferase reporter plasmids for NMNAT2
     Search ThermoFisher Antibodies for NMNAT2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMNAT2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NMNAT2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NMNAT2
    Customized:
     lentivirus for stable overexpression of NMNAT2
     lentivirus expression plasmids for stable overexpression of NMNAT2
     adenovirus for overexpression of NMNAT2
     LSBio Antibodies in human, mouse, rat for NMNAT2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NMNAT2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4