External Ids for NMI Gene
Previous GeneCards Identifiers for NMI Gene
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
GeneCards Summary for NMI Gene
NMI (N-Myc (And STAT) Interactor) is a Protein Coding gene. Among its related pathways are IL-2 Pathway and IL2-mediated signaling events. GO annotations related to this gene include transcription cofactor activity. An important paralog of this gene is IFI35.
UniProtKB/Swiss-Prot for NMI Gene
May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5