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Aliases for NMI Gene

Aliases for NMI Gene

  • N-Myc (And STAT) Interactor 2 3
  • N-Myc And STAT Interactor 4
  • N-Myc Interactor 3
  • N-Myc-Interactor 3
  • Nmi 4

External Ids for NMI Gene

Previous GeneCards Identifiers for NMI Gene

  • GC02M149820
  • GC02M150656
  • GC02M152091
  • GC02M152329
  • GC02M151952
  • GC02M151835
  • GC02M152126
  • GC02M144023

Summaries for NMI Gene

Entrez Gene Summary for NMI Gene

  • NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]

GeneCards Summary for NMI Gene

NMI (N-Myc (And STAT) Interactor) is a Protein Coding gene. Among its related pathways are IL-2 Pathway and Prolactin Signaling Pathway. GO annotations related to this gene include transcription cofactor activity. An important paralog of this gene is IFI35.

UniProtKB/Swiss-Prot for NMI Gene

  • May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5

Gene Wiki entry for NMI Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMI Gene

Genomics for NMI Gene

Regulatory Elements for NMI Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NMI Gene

Start:
151,270,465 bp from pter
End:
151,290,057 bp from pter
Size:
19,593 bases
Orientation:
Minus strand

Genomic View for NMI Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NMI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMI Gene

Proteins for NMI Gene

  • Protein details for NMI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13287-NMI_HUMAN
    Recommended name:
    N-myc-interactor
    Protein Accession:
    Q13287
    Secondary Accessions:
    • B5BU69
    • Q53TI8
    • Q9BVE5

    Protein attributes for NMI Gene

    Size:
    307 amino acids
    Molecular mass:
    35057 Da
    Quaternary structure:
    • Interacts with MYCN and MYC, as well as with other transcription factors with a Zip, HLH or a HLH-Zip motif. Interacts with all STAT proteins except STAT2.

neXtProt entry for NMI Gene

Proteomics data for NMI Gene at MOPED

Post-translational modifications for NMI Gene

  • Ubiquitination at Lys70, Lys95, Lys102, Lys111, Lys129, Lys183, Lys245, Lys284, and Lys294
  • Modification sites at PhosphoSitePlus

Other Protein References for NMI Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NMI Gene

Domains for NMI Gene

Protein Domains for NMI Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NMI Gene

Graphical View of Domain Structure for InterPro Entry

Q13287

UniProtKB/Swiss-Prot:

NMI_HUMAN :
  • Q13287
Family:
  • Belongs to the NMI family.
genes like me logo Genes that share domains with NMI: view

No data available for Gene Families for NMI Gene

Function for NMI Gene

Molecular function for NMI Gene

GENATLAS Biochemistry: N-myc interactor,also interacting with c-myc,Max and STATs (except STAT2) transcription factors carrying leucine zipper with/without helix-loop-helix,expressed at low levels in all fetal and adult tissues,except brain,increasing STA mediated transcription in response to IL2 and IFNG
UniProtKB/Swiss-Prot Function: May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5
UniProtKB/Swiss-Prot Induction: By IL2/interleukin-2 and IFNG/IFN-gamma

Gene Ontology (GO) - Molecular Function for NMI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity TAS 10779520
GO:0005515 protein binding IPI 10597290
genes like me logo Genes that share ontologies with NMI: view

Phenotypes for NMI Gene

GenomeRNAi human phenotypes for NMI:
genes like me logo Genes that share phenotypes with NMI: view

Animal Model Products

CRISPR Products

miRNA for NMI Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NMI

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NMI Gene

Localization for NMI Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMI Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMI Gene COMPARTMENTS Subcellular localization image for NMI gene
Compartment Confidence
nucleus 4
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for NMI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NMI: view

Pathways for NMI Gene

genes like me logo Genes that share pathways with NMI: view

Pathways by source for NMI Gene

1 Qiagen pathway for NMI Gene
1 BioSystems pathway for NMI Gene
1 GeneGo (Thomson Reuters) pathway for NMI Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NMI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS 9989503
GO:0006954 inflammatory response TAS 9989503
GO:0007259 JAK-STAT cascade TAS 10597290
GO:1903506 regulation of nucleic acid-templated transcription TAS 10779520
GO:2001141 regulation of RNA biosynthetic process --
genes like me logo Genes that share ontologies with NMI: view

Transcripts for NMI Gene

Unigene Clusters for NMI Gene

N-myc (and STAT) interactor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NMI

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMI Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2:
SP3: - - -
SP4: -
SP5: -

Relevant External Links for NMI Gene

GeneLoc Exon Structure for
NMI
ECgene alternative splicing isoforms for
NMI

Expression for NMI Gene

mRNA expression in normal human tissues for NMI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMI Gene

This gene is overexpressed in Whole Blood (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NMI Gene

SOURCE GeneReport for Unigene cluster for NMI Gene Hs.54483

mRNA Expression by UniProt/SwissProt for NMI Gene

Q13287-NMI_HUMAN
Tissue specificity: Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver
genes like me logo Genes that share expressions with NMI: view

In Situ Assay Products

Orthologs for NMI Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMI 35
  • 99.67 (n)
  • 99.35 (a)
NMI 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NMI 35
  • 82.3 (n)
  • 72.96 (a)
NMI 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMI 35
  • 79.48 (n)
  • 70.68 (a)
NMI 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmi 35
  • 73.72 (n)
  • 64.82 (a)
Nmi 16
Nmi 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMI 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nmi 35
  • 73.75 (n)
  • 67.03 (a)
chicken
(Gallus gallus)
Aves NMI 35
  • 57.09 (n)
  • 41.45 (a)
NMI 36
  • 30 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMI 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmi 35
  • 51.19 (n)
  • 36.7 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC792676 35
  • 47.22 (n)
  • 34.37 (a)
NMI 36
  • 24 (a)
OneToOne
Species with no ortholog for NMI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMI Gene

ENSEMBL:
Gene Tree for NMI (if available)
TreeFam:
Gene Tree for NMI (if available)

Paralogs for NMI Gene

Paralogs for NMI Gene

genes like me logo Genes that share paralogs with NMI: view

Variants for NMI Gene

Sequence variations from dbSNP and Humsavar for NMI Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11730 -- 151,270,497(-) ATAAG(C/T)GCACT utr-variant-3-prime
rs289828 -- 151,280,667(-) AAACC(A/G)GCCAG intron-variant
rs289829 -- 151,280,387(-) TAAAT(C/T)GAATG intron-variant
rs289830 -- 151,279,344(-) TTTGA(G/T)ATAGT intron-variant
rs289831 -- 151,279,000(-) TTTCA(C/T)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMI Gene

Variant ID Type Subtype PubMed ID
esv34659 CNV Loss 17911159
nsv523849 CNV Gain 19592680
nsv834417 CNV Gain 17160897

Relevant External Links for NMI Gene

HapMap Linkage Disequilibrium report
NMI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMI Gene

Disorders for NMI Gene

(1) Novoseek inferred disease relationships for NMI Gene

Disease -log(P) Hits PubMed IDs
cancer 0 2

Relevant External Links for NMI

Genetic Association Database (GAD)
NMI
Human Genome Epidemiology (HuGE) Navigator
NMI
genes like me logo Genes that share disorders with NMI: view

No data available for UniProtKB/Swiss-Prot for NMI Gene

Publications for NMI Gene

  1. Isolation and characterization of Nmi, a novel partner of Myc proteins. (PMID: 8668343) Bao J. … Zervos A.S. (Oncogene 1996) 2 3 4 23
  2. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. (PMID: 9989503) Zhu M.-H. … Leonard W.J. (Cell 1999) 2 3 4
  3. Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35. (PMID: 10779520) Zhou X. … Omary M.B. (J. Biol. Chem. 2000) 3 23
  4. Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells. (PMID: 11911807) Chen J. … Naumovski L. (J. Interferon Cytokine Res. 2002) 3 23
  5. [Identification of a protein interacting with apoptin from human leucocyte cDNA library by using yeast two-hybrid screening]. (PMID: 12019454) Sun G.J. … Sun Z.X. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2002) 3 23

Products for NMI Gene

Sources for NMI Gene

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