Aliases for NME9 Gene
Aliases for NME9 Gene
External Ids for NME9 Gene
- HGNC: 21343
- Entrez Gene: 347736
- Ensembl: ENSG00000181322
- UniProtKB: Q86XW9
Previous HGNC Symbols for NME9 Gene
- TXNDC6
Previous GeneCards Identifiers for NME9 Gene
- GC03M137981
Summaries for NME9 Gene
GeneCards Summary for NME9 Gene
NME9 (NME/NM23 Family Member 9) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME8.
UniProtKB/Swiss-Prot for NME9 Gene
-
May be a regulator of microtubule physiology.
Additional gene information for NME9 Gene
- Monarch Initiative
- Search for NME9 at DataMed
- Search for NME9 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME9 Gene
Genomics for NME9 Gene
GeneHancer (GH) Regulatory Elements for NME9 Gene
Promoters and enhancers for NME9 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03I138326 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 550.8 | +1.8 | 1822 | 4.4 | HDGF ELF3 PKNOX1 FOXA2 ARID4B SIN3A BMI1 ZBTB40 RAD21 ZNF335 | NME9 A4GNT GC03P138286 | |
| GH03I138410 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 11.5 | -82.3 | -82301 | 3.7 | ETV1 BACH1 ZNF644 ZBTB40 ZNF507 RELA FOSL1 ZNF766 VEZF1 FOS | NME9 MRAS ESYT3 LOC105374129 GC03P138407 GC03M138428 | |
| GH03I138417 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 11.7 | -88.3 | -88346 | 1.8 | CTCF FOXA2 ZSCAN4 SIN3A ZNF2 RAD21 GATA3 ZNF316 ZNF143 SMC3 | NME9 LOC105374129 GC03M138428 GC03P138407 | |
| GH03I138367 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 11.5 | -37.7 | -37652 | 1.2 | RFX1 EGR1 ZSCAN4 BMI1 | NME9 MRAS GC03M138344 GC03P138407 | |
| GH03I138387 | Enhancer | 0.9 | Ensembl dbSUPER | 10.8 | -54.0 | -53952 | 0.2 | HDAC1 TEAD4 TAL1 TCF12 CTBP1 NCOR1 CBFA2T2 TRIM24 SOX6 CBFA2T3 | NME9 GC03P138407 GC03M138344 MRAS |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NME9 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NME9 Gene
Genomic Locations for NME9 Gene
- chr3:138,261,437-138,330,149
- (GRCh38/hg38)
- Size:
- 68,713 bases
- Orientation:
- Minus strand
- chr3:137,980,279-138,048,728
- (GRCh37/hg19)
Genomic View for NME9 Gene
Genes around NME9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q22.3 by Ensembl
- 3q22.3 by Entrez Gene
- 3q22.3 by HGNC
NME9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NME9 Gene
Proteins for NME9 Gene
-
Protein details for NME9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86XW9-TXND6_HUMAN
- Recommended name:
- Thioredoxin domain-containing protein 6
- Protein Accession:
- Q86XW9
- Q7Z4A8
- Q8N1V7
Protein attributes for NME9 Gene
- Size:
- 330 amino acids
- Molecular mass:
- 36856 Da
- Quaternary structure:
-
- Monomer and homodimer.
- Miscellaneous:
-
- Shows no detectable enzyme activity.
Protein Expression for NME9 Gene
Post-translational modifications for NME9 Gene
No Post-translational modifications
Other Protein References for NME9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001335947.1
- NP_001335949.1
- NP_001335950.1
- NP_001335951.1
- NP_001335952.1
- NP_001335953.1
- NP_001335954.1
- NP_835231.1
- XP_005247486.1
- XP_006713678.1
- XP_011511076.1
- XP_011511079.1
- XP_016861795.1
- XP_016861796.1
- XP_016861797.1
- XP_016861798.1
- XP_016861799.1
- XP_016861800.1
- XP_016861801.1
- XP_016861802.1
- XP_016861803.1
- XP_016861804.1
- XP_016861805.1
- XP_016861806.1
- XP_016861807.1
- XP_016861808.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for NME9
- Novus Biologicals Antibodies for NME9
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- GeneTex NME9 antibody for NME9
Protein Products
-
OriGene Purified Proteins for NME9
- Search Origene for MassSpec and Protein Over-expression Lysates for NME9
- Origene Custom Protein Services for NME9
- antibodies-online: Search results for available NME9 related products ranked by validation data
- Search GeneTex for Proteins for NME9
Assay Products
- antibodies-online: Search results for available NME9 related products ranked by validation data
No data available for DME Specific Peptides for NME9 Gene
Domains & Families for NME9 Gene
Gene Families for NME9 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for NME9 Gene
Suggested Antigen Peptide Sequences for NME9 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86XW9- Family:
-
- Belongs to the NDK family.
Function for NME9 Gene
Molecular function for NME9 Gene
- UniProtKB/Swiss-Prot Function:
- May be a regulator of microtubule physiology.
Phenotypes From GWAS Catalog for NME9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004550 | nucleoside diphosphate kinase activity | IBA | -- |
Phenotypes for NME9 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for NME9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NME9 gene
- Search ViGene Biosciences for NME9
CRISPR Products
-
OriGene CRISPR knockouts for NME9
- genomics-online: gRNA clones - Search results for 38 available NME9 gene related products
- Overview of 38 available NME9 gene related products
- Applied Biological Materials CRISPR for NME9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NME9
- GenScript: Design CRISPR guide RNA sequences for NME9
miRNA Products
- Search ViGene Biosciences for NME9
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for NME9
- Browse OriGene Inhibitory RNA Products For NME9
- genomics-online: shRNA clones - Search results for 38 available NME9 gene related products
- Overview of 38 available NME9 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NME9 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NME9
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NME9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NME9
-
ViGene Biosciences adenoviral particle packaged cDNA for NME9 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NME9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NME9 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NME9 Gene
Localization for NME9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NME9 Gene
- Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 3 |
| nucleus | 3 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IBA | -- |
| GO:0005623 | cell | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NME9 Gene
Pathways & Interactions for NME9 Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006165 | nucleoside diphosphate phosphorylation | IEA | -- |
| GO:0006183 | GTP biosynthetic process | IEA | -- |
| GO:0006228 | UTP biosynthetic process | IEA | -- |
| GO:0006241 | CTP biosynthetic process | IEA | -- |
| GO:0045454 | cell redox homeostasis | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for NME9 Gene
Transcripts for NME9 Gene
mRNA/cDNA for NME9 Gene
- (26) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (15) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NME9 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NME9
- genomics-online: gRNA clones - Search results for 38 available NME9 gene related products
- Overview of 38 available NME9 gene related products
- Applied Biological Materials CRISPR for NME9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NME9
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miRNA Products
- Search ViGene Biosciences for NME9
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for NME9
- Browse OriGene Inhibitory RNA Products For NME9
- genomics-online: shRNA clones - Search results for 38 available NME9 gene related products
- Overview of 38 available NME9 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NME9 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NME9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NME9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NME9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NME9 Gene
This gene is overexpressed in Neutrophil (45.5) and Heart (23.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NME9 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NME9 Gene:
NME9SOURCE GeneReport for Unigene cluster for NME9 Gene:
Hs.660992mRNA Expression by UniProt/SwissProt for NME9 Gene:
Q86XW9-TXND6_HUMAN
Tissue specificity:
Detected at very low levels in testis, lung and brain.
Evidence on tissue expression from TISSUES for NME9 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for NME9
- genomics-online: primer clones - Search results for 38 available NME9 gene related products
- Overview of 38 available NME9 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NME9 Gene
Orthologs for NME9 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TXNDC6 33 |
|
||
| NME9 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | NME9 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | NME9 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nme9 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Nme9 33 16 |
|
||
| 1600029I14Rik 34 |
|
OneToOne | |||
| oppossum (Monodelphis domestica) |
Mammalia | NME9 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NME9 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | nme8 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | nmdyn-D6 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for NME9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NME9 Gene
Variants for NME9 Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs9289556 | benign, not specified | 138,314,339(-) | C/T | 5_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
| rs1000022483 | -- | 138,262,137(-) | G/A/C | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000266002 | -- | 138,318,274(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000282302 | -- | 138,327,874(-) | C/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000327694 | -- | 138,269,253(-) | A/C | genic_downstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.07;
37.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NME9 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NME9
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NME9 Gene
Disorders for NME9 Gene
Additional Disease Information for NME9
No disorders were found for NME9 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NME9 Gene
Publications for NME9 Gene
- Characterization of human thioredoxin-like 2. A novel microtubule-binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme. (PMID: 12569107) Sadek CM … Miranda-Vizuete A (The Journal of biological chemistry 2003) 2 3 4 22 58
- Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T … Bobe J (BMC evolutionary biology 2009) 2 3 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Thioredoxin-like protein 2b facilitates colon cancer cell proliferation and inhibits apoptosis via NF-κB pathway. (PMID: 25555669) Lu Y … Fan D (Cancer letters 2015) 3 58
- Thioredoxin-like protein 2 is overexpressed in colon cancer and promotes cancer cell metastasis by interaction with ran. (PMID: 23311631) Lu Y … Fan D (Antioxidants & redox signaling 2013) 3 58
Products for NME9 Gene
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- Invitrogen Antibodies for NME9
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NME9
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 41 available NME9 Antibodies ranked by validation data
- Compare Top NME9 Antibodies
- antibodies-online: Search results for available NME9 related products ranked by validation data
- antibodies-online: Search results for available NME9 related products ranked by validation data
- GeneTex NME9 antibody for NME9
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- ViGene Biosciences adenoviral particle packaged cDNA for NME9 gene
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- Overview of 38 available NME9 gene related products
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- Overview of 38 available NME9 gene related products
Sources for NME9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
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