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Aliases for NME9 Gene

Aliases for NME9 Gene

  • NME/NM23 Family Member 9 2 3 5
  • Thioredoxin-Like Protein 2 3 4
  • NME Gene Family Member 9 2 3
  • TXNDC6 3 4
  • TXL-2 3 4
  • TXL2 3 4
  • Thioredoxin Domain-Containing Protein 6 3
  • Thioredoxin Domain Containing 6 2
  • NME Family Member 9 2
  • NM23-H9 3

External Ids for NME9 Gene

Previous HGNC Symbols for NME9 Gene

  • TXNDC6

Previous GeneCards Identifiers for NME9 Gene

  • GC03M137981

Summaries for NME9 Gene

GeneCards Summary for NME9 Gene

NME9 (NME/NM23 Family Member 9) is a Protein Coding gene. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME8.

UniProtKB/Swiss-Prot for NME9 Gene

  • May be a regulator of microtubule physiology.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME9 Gene

Genomics for NME9 Gene

Regulatory Elements for NME9 Gene

Enhancers for NME9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F138410 1.1 Ensembl ENCODE 11.5 -82.2 -82193 3.9 PTRF FOS HDAC8 CREB3 TFDP1 MEF2D ZNF589 SMARCA4 PBX2 IKZF1 NME9 MRAS ESYT3 LOC105374129 GC03M138428
GH03F138417 1 Ensembl ENCODE 11.7 -88.3 -88346 1.8 CTCF ZNF2 RAD21 ZNF316 GATA3 ZNF143 SMC3 MAFK RFX1 ZNF654 NME9 LOC105374129 GC03M138428
GH03F138381 1.3 FANTOM5 Ensembl ENCODE 6.4 -52.1 -52058 1.8 SOX13 ELF3 CTCF SAP130 MAX CEBPG DMAP1 ZNF644 RARA TEAD3 MRAS NME9 ESYT3 GC03P138407 GC03M138344
GH03F138366 0.7 Ensembl ENCODE 11.5 -37.5 -37458 1.6 RFX1 BMI1 NME9 MRAS GC03M138344 GC03P138407
GH03F138371 0.7 Ensembl 11.5 -41.3 -41260 0.8 PKNOX1 MAZ ZNF146 TBL1XR1 MTA2 CBFB JUNB TBX21 RELA JUND MRAS NME9 GC03M138344 GC03P138407
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NME9 on UCSC Golden Path with GeneCards custom track

Promoters for NME9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NME9 Gene

138,261,437 bp from pter
138,330,149 bp from pter
68,713 bases
Minus strand

Genomic View for NME9 Gene

Genes around NME9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME9 Gene

Proteins for NME9 Gene

  • Protein details for NME9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q7Z4A8
    • Q8N1V7

    Protein attributes for NME9 Gene

    330 amino acids
    Molecular mass:
    36856 Da
    Quaternary structure:
    • Monomer and homodimer.
    • Shows no detectable enzyme activity.

    Alternative splice isoforms for NME9 Gene


neXtProt entry for NME9 Gene

Post-translational modifications for NME9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NME9 Gene

Domains & Families for NME9 Gene

Gene Families for NME9 Gene

Suggested Antigen Peptide Sequences for NME9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.
  • Belongs to the NDK family.
  • Contains 1 thioredoxin domain.
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME9: view

Function for NME9 Gene

Molecular function for NME9 Gene

UniProtKB/Swiss-Prot Function:
May be a regulator of microtubule physiology.

Gene Ontology (GO) - Molecular Function for NME9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IEA --
genes like me logo Genes that share ontologies with NME9: view
genes like me logo Genes that share phenotypes with NME9: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NME9 Gene

Localization for NME9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NME9 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NME9 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for NME9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with NME9: view

Pathways & Interactions for NME9 Gene

No Data Available

Interacting Proteins for NME9 Gene

Gene Ontology (GO) - Biological Process for NME9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with NME9: view

No data available for Pathways by source and SIGNOR curated interactions for NME9 Gene

Transcripts for NME9 Gene

Unigene Clusters for NME9 Gene

NME/NM23 family member 9:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME9 Gene

No ASD Table

Relevant External Links for NME9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NME9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NME9 Gene

Protein differential expression in normal tissues from HIPED for NME9 Gene

This gene is overexpressed in Neutrophil (45.5) and Heart (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NME9 Gene

Protein tissue co-expression partners for NME9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NME9 Gene:


SOURCE GeneReport for Unigene cluster for NME9 Gene:


mRNA Expression by UniProt/SwissProt for NME9 Gene:

Tissue specificity: Detected at very low levels in testis, lung and brain.
genes like me logo Genes that share expression patterns with NME9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NME9 Gene

Orthologs for NME9 Gene

This gene was present in the common ancestor of animals.

Orthologs for NME9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TXNDC6 34
  • 99.46 (n)
NME9 35
  • 94 (a)
(Bos Taurus)
Mammalia NME9 34 35
  • 88.76 (n)
(Canis familiaris)
Mammalia NME9 34 35
  • 87.95 (n)
(Rattus norvegicus)
Mammalia Nme9 34
  • 80.93 (n)
(Mus musculus)
Mammalia Nme9 34 16
  • 80.79 (n)
1600029I14Rik 35
  • 80 (a)
(Monodelphis domestica)
Mammalia NME9 35
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia NME9 35
  • 45 (a)
(Danio rerio)
Actinopterygii nme8 35
  • 22 (a)
fruit fly
(Drosophila melanogaster)
Insecta nmdyn-D6 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
Species where no ortholog for NME9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NME9 Gene

Gene Tree for NME9 (if available)
Gene Tree for NME9 (if available)

Paralogs for NME9 Gene

Paralogs for NME9 Gene

(2) SIMAP similar genes for NME9 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NME9: view

Variants for NME9 Gene

Sequence variations from dbSNP and Humsavar for NME9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10513051 -- 138,291,129(-) CTATT(C/T)TGAGG intron-variant
rs1054717 -- 138,296,700(+) GGCTT(C/T)CAAGT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1054769 -- 138,298,289(+) TAAGC(A/C)CTTTA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10580643 -- 138,322,486(+) AAGGG(-/GTGT)GTGTG intron-variant
rs10935280 -- 138,333,371(+) TGGGA(G/T)GCCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NME9 Gene

Variant ID Type Subtype PubMed ID
nsv4030 CNV insertion 18451855
nsv428422 CNV gain+loss 18775914
nsv528349 CNV loss 19592680
nsv822263 CNV loss 20364138
nsv822264 CNV loss 20364138

Variation tolerance for NME9 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NME9 Gene

Disorders for NME9 Gene

Relevant External Links for NME9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NME9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NME9 Gene

Publications for NME9 Gene

  1. Characterization of human thioredoxin-like 2. A novel microtubule- binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme. (PMID: 12569107) Sadek C.M. … Miranda-Vizuete A. (J. Biol. Chem. 2003) 2 3 4 22 64
  2. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T. … Bobe J. (BMC Evol. Biol. 2009) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Thioredoxin-like protein 2b facilitates colon cancer cell proliferation and inhibits apoptosis via NF-I_B pathway. (PMID: 25555669) Lu Y. … Fan D. (Cancer Lett. 2015) 3 64
  5. Thioredoxin-like protein 2 is overexpressed in colon cancer and promotes cancer cell metastasis by interaction with ran. (PMID: 23311631) Lu Y. … Fan D. (Antioxid. Redox Signal. 2013) 3 64

Products for NME9 Gene

Sources for NME9 Gene

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