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NME9 Gene

protein-coding   GIFtS: 42
GCID: GC03M137981

NME/NM23 Family Member 9

(Previous names: thioredoxin domain containing 6, NME gene family member...)
(Previous symbol: TXNDC6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NME/NM23 Family Member 91 2     TXL22 3
TXNDC61 2 3     NM23-H92
NME Family Member 91 2     TXL-22
NME Gene Family Member 91 2     Thioredoxin Domain-Containing Protein 62
Thioredoxin Domain Containing 61 2     Thioredoxin-Like 22
Thioredoxin-Like Protein 22 3     Txl-23

External Ids:    HGNC: 213431   Entrez Gene: 3477362   Ensembl: ENSG000001813227   UniProtKB: Q86XW93   

Export aliases for NME9 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NME9 Gene:
NME9 (NME/NM23 family member 9) is a protein-coding gene. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME2.

UniProtKB/Swiss-Prot: TXND6_HUMAN, Q86XW9
Function: May be a regulator of microtubule physiology




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NME9
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNME9 promoter sequence
   Search Chromatin IP Primers for NME9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q22.3

NME9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME9 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M137981:  view genomic region     (about GC identifiers)

Start:
137,980,279 bp from pter      End:
138,048,728 bp from pter
Size:
68,450 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TXND6_HUMAN, Q86XW9 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 6  
Size: 330 amino acids; 36856 Da
Subunit: Monomer and homodimer
Miscellaneous: Shows no detectable enzyme activity
Secondary accessions: Q7Z4A8 Q8N1V7
Alternative splicing: 3 isoforms:  Q86XW9-1   Q86XW9-2   Q86XW9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NME9: NX_Q86XW9

Explore proteomics data for NME9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NME9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_835231.1  
    ENSEMBL proteins: 
     ENSP00000372667   ENSP00000419355   ENSP00000419882   ENSP00000335444   ENSP00000420435  
     ENSP00000419147   ENSP00000420668   ENSP00000420258   ENSP00000341084   ENSP00000321929  
     ENSP00000440143  

    NME9 Human Recombinant Protein Products:

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    Novus Biologicals NME9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NME9 

     
    Search antibodies-online for proteins for NME9 

     
    antibodies-online peptides for NME9

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    antibodies-online antibodies for NME9 (16 products) 

    NME9 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for NME9 
    antibodies-online kits for NME9 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001564 Nucleoside_diP_kinase
     IPR012336 Thioredoxin-like_fold
     IPR013766 Thioredoxin_domain
     IPR017937 Thioredoxin_CS

    Graphical View of Domain Structure for InterPro Entry Q86XW9

    ProtoNet protein and cluster: Q86XW9

    3 Blocks protein domains:
    IPB000408 Regulator of chromosome condensation
    IPB001564 Nucleoside diphosphate kinase
    IPB006662 Thioredoxin type domain


    UniProtKB/Swiss-Prot: TXND6_HUMAN, Q86XW9
    Similarity: Belongs to the NDK family
    Similarity: Contains 1 thioredoxin domain


    Find genes that share domains with NME9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXND6_HUMAN, Q86XW9
    Function: May be a regulator of microtubule physiology

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004550nucleoside diphosphate kinase activity IEA--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with NME9           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NME9

    miRNA
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    Block miRNA regulation of human, mouse, rat NME9 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidNME9 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat NME9

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TXND6_HUMAN, Q86XW9: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with
    microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette (By
    similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--

    Find genes that share ontologies with NME9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NME9
    Interactions:

        Search GeneGlobe Interaction Network for NME9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for NME9 (ENSP000003219294) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO4ENSP000003186354STRING: ENSP00000318635
    GSRENSP000002211304STRING: ENSP00000221130
    MSRAENSP000003139214STRING: ENSP00000313921
    NSFENSP000003812934STRING: ENSP00000381293
    PRDX5ENSP000002654624STRING: ENSP00000265462
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    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006165nucleoside diphosphate phosphorylation ----
    GO:0006183GTP biosynthetic process IEA--
    GO:0006228UTP biosynthetic process IEA--
    GO:0006241CTP biosynthetic process IEA--
    GO:0045454cell redox homeostasis IEA--

    Find genes that share ontologies with NME9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NME9 (TXND6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NME9 gene: 
    NM_178130.2  

    Unigene Cluster for NME9:

    NME/NM23 family member 9
    Hs.660992  [show with all ESTs]
    Unigene Representative Sequence: NM_178130
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383180(uc003ese.1) ENST00000492993 ENST00000484930 ENST00000333911(uc003esg.3)
    ENST00000474690 ENST00000478220 ENST00000475751 ENST00000488716 ENST00000460099
    ENST00000341790 ENST00000317876(uc003esd.1 uc010huf.1) ENST00000536478

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidNME9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NME9
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      QuantiFast Probe-based Assays in human, mouse, rat NME9

    Additional mRNA sequence: 

    AF196568.1 AK094830.1 AY336746.1 BC107054.2 

    6 DOTS entries:

    DT.75119193  DT.40113384  DT.65286059  DT.91703436  DT.91998524  DT.92415449 

    15 AceView cDNA sequences:

    NM_178130 CA868240 AK094830 AI611656 AF196568 BF736559 CA867993 BG570189 
    BU607430 AY336746 CA312568 BE673422 BF850566 CD699916 AW869049 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NME9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTGCTGT
    NME9 Expression
    About this image

    NME9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NME9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660992

    UniProtKB/Swiss-Prot: TXND6_HUMAN, Q86XW9
    Tissue specificity: Detected at very low levels in testis, lung and brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NME9 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nme91 , 5 thioredoxin domain containing 65
    NME/NM23 family member 91
    80.79(n)1
    79.39(a)1
      9 (51.72 cM)5
    6235341  NM_001165957.11  NP_001159429.11 
     994562435 
    zebrafish
    (Danio rerio)
    Actinopterygii nme86
    NME/NM23 family member 8
    22(a)
    1 ↔ 1
    9(54049364-54120095) ENSDARG00000076395
    fruit fly
    (Drosophila melanogaster)
    Insecta nmdyn-D66
    nmdyn-D6
    17(a)
    1 → many
    X(14477710-14478649)


    ENSEMBL Gene Tree for NME9 (if available)
    TreeFam Gene Tree for NME9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NME9 gene
    NME22  NME12  NME32  NME82  NME42  NME72  NME1-NME22  NME62  
    NME52  
    2 SIMAP similar genes for NME9 using alignment to 5 protein entries:     TXND6_HUMAN (see all proteins):
    TXNDC6    NME8

    Find genes that share paralogs with NME9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NME9 (see all 557)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867409651,2
    C--138017732(+) GGAGGA/GTGATG 1 -- int10--------
    rs1146839991,2
    C,F--138017799(+) TAAGGC/TGAAGA 1 -- int11Minor allele frequency- T:0.02WA 118
    rs778442781,2
    C,F--138017919(+) GGCTGA/CCAGAA 1 -- int11Minor allele frequency- C:0.07WA 118
    rs1386847111,2
    --138018217(+) AGCCCA/GGCCTG 1 -- int10--------
    rs64398001,2
    C,F,H--138018341(+) CGCCAA/GTGAGT 1 -- int124Minor allele frequency- G:0.06NA NS EA WA CSA 1786
    rs1416040161,2
    --138018399(+) CCTTAC/TACCCC 1 -- int10--------
    rs1390866441,2
    --138018493(+) AGTAAC/TGGGAG 1 -- int10--------
    rs1416558621,2
    C--138018574(+) CTGCCA/CAGCTA 1 -- int10--------
    rs779951881,2
    C--138018607(+) AACACC/TCCCCG 1 -- int10--------
    rs1505111701,2
    --138018646(+) TTCCCC/TTCTCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for NME9 (137980279 - 138048728 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NME9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4030CNV Insertion18451855
    nsv528349CNV Loss19592680
    nsv822263CNV Loss20364138
    nsv822264CNV Loss20364138
    nsv877537CNV Gain21882294
    nsv428422CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NME9
    DNA2.0 Custom Variant and Variant Library Synthesis for NME9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NME9 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NME9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human thioredoxin-like 2. A novel microtubule- binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme. (PubMed id 12569107)1, 2, 3, 9 Sadek C.M....Miranda-Vizuete A. (J. Biol. Chem. 2003)
    2. Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)1, 3 Desvignes T....Bobe J. (BMC Evol. Biol. 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Thioredoxin-like protein 2 is overexpressed in colon cancer and promotes cancer cell metastasis by interaction with ran. (PubMed id 23311631)1 Lu Y....Fan D. (amp 2013)
    5. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1 Furney S.J.... . (Mol. Psychiatry 2011)
    6. Proteomic analysis in lung tissue of smokers and COPD patients. (PubMed id 18753468)1 Lee E.J....Uhm C.S. (Chest 2009)
    7. Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. (PubMed id 16236267)1 Guo D.... Wang C.-Y. (Biochem. Biophys. Res. Commun. 2005)
    8. The mammalian testis-specific thioredoxin system. (PubMed id 14713334)1 Miranda-Vizuete A....Oko R. (amp 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Identification and distribution of thioredoxin-like 2 as the antigen for the monoclonal antibody MC3 specific to colorectal cancer. (PubMed id 18528843)9 Lu Y....Fan D. (Proteomics 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 347736 HGNC: 21343 AceView: TXNDC6 Ensembl:ENSG00000181322 euGenes: HUgn347736
    ECgene: NME9 H-InvDB: NME9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NME9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NME9 gene:
    Search GeneIP for patents involving NME9

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Block miRNA regulation of human, mouse, rat NME9 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NME9
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     QuantiFast Probe-based Assays in human, mouse, rat NME9 QuantiTect SYBR Green Assays in human, mouse, rat NME9
     Custom PCR Arrays for NME9 Search Chromatin IP Primers for NME9
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     Browse ESI BIO Cell Lines and PureStem Progenitors for NME9
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     SwitchGear 3'UTR luciferase reporter plasmids for NME9
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