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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NME9 Gene

protein-coding GIFtS: 43
GCID: GC03M137981

NME/NM23 family member 9

(Previous names: thioredoxin domain containing 6, NME gene family member...)
(Previous symbol: TXNDC6)

Explore 4 diseases affiliated with
NME9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NME/NM23 Family Member 9¹ ²		Thioredoxin Domain Containing 6¹ ²
TXNDC6¹ ² ³		Thioredoxin-Like Protein 2² ³
NM23-H9¹ ²		TXL2² ³
TXL-2¹ ²		Thioredoxin Domain-Containing Protein 6²
NME Family Member 9¹ ²		Thioredoxin-Like 2²
NME Gene Family Member 9¹ ²		Txl-2³

External Ids:	HGNC: 21343¹	Entrez Gene: 347736²	Ensembl: ENSG00000181322⁷	UniProtKB: Q86XW9³

Export aliases for NME9 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TXND6_HUMAN, Q86XW9

Function: May be a regulator of microtubule physiology

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for NME9
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NME9 promoter sequence

Search SABiosciences Chromatin IP Primers for NME9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NME9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3 Ensembl cytogenetic band: 3q22.3 HGNC cytogenetic band: 3q22.3

NME9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME9 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M137981: view genomic region (about GC identifiers)

Start:	137,980,279 bp from pter	End:	138,048,728 bp from pter
Size:	68,450 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TXND6_HUMAN, Q86XW9 (See protein sequence)

Recommended Name: Thioredoxin domain-containing protein 6

Size: 330 amino acids; 36856 Da

Subunit: Monomer and homodimer

Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with

microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette (By

similarity)

Miscellaneous: Shows no detectable enzyme activity

Secondary accessions: Q7Z4A8 Q8N1V7

Alternative splicing: 3 isoforms: Q86XW9-1 Q86XW9-2 Q86XW9-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NME9: NX_Q86XW9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86XW9

NME9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_835231.1

ENSEMBL proteins:

ENSP00000372667 ENSP00000419355 ENSP00000419882 ENSP00000335444 ENSP00000420435

ENSP00000419147 ENSP00000420668 ENSP00000420258 ENSP00000341084 ENSP00000321929

ENSP00000440143

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	Uscn Proteins for NME9

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--

NME9 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NME9 for domains About GeneDecksing

4 InterPro domains/families:

IPR001564 Nucleoside_diP_kinase

IPR013766 Thioredoxin_domain

IPR017937 Thioredoxin_CS

IPR012336 Thioredoxin-like_fold

Graphical View of Domain Structure for InterPro Entry Q86XW9

ProtoNet protein and cluster: Q86XW9

3 Blocks protein families:

IPB000408 Regulator of chromosome condensation

IPB001564 Nucleoside diphosphate kinase

IPB006662 Thioredoxin type domain

UniProtKB/Swiss-Prot: TXND6_HUMAN, Q86XW9

Similarity: Belongs to the NDK family

Similarity: Contains 1 thioredoxin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TXND6_HUMAN, Q86XW9

Function: May be a regulator of microtubule physiology

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004550	nucleoside diphosphate kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--

NME9 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NME9

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for NME9 (ENSP00000321929⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SUMO4	ENSP00000318635⁴	STRING: ENSP00000318635

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006183	GTP biosynthetic process	IEA	--
GO:0006228	UTP biosynthetic process	IEA	--
GO:0006241	CTP biosynthetic process	IEA	--
GO:0045454	cell redox homeostasis	IEA	--

NME9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NME9
Search CenterWatch for drugs/clinical trials and news about NME9 / TXND6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for NME9 gene:

NM_178130.2

Unigene Cluster for NME9:

NME/NM23 family member 9

Hs.660992 [show with all ESTs]

Unigene Representative Sequence: NM_178130

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000383180(uc003ese.1) ENST00000492993 ENST00000484930 ENST00000333911(uc003esg.3)

ENST00000474690 ENST00000478220 ENST00000475751 ENST00000488716 ENST00000460099

ENST00000341790 ENST00000317876(uc003esd.1 uc010huf.1) ENST00000536478

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Additional cDNA sequence:

AF196568.1 AK094830.1 AY336746.1 BC107054.2

6 DOTS entries:

DT.75119193 DT.40113384 DT.65286059 DT.91703436 DT.91998524 DT.92415449

15 AceView cDNA sequences:

AK094830 NM_178130 CA868240 AI611656 CA867993 AF196568 BG570189 BF736559

AY336746 CA312568 BU607430 BE673422 BF850566 CD699916 AW869049

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NME9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTTGCTGT

About this image
See NME9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NME9

SOURCE GeneReport for Unigene cluster: Hs.660992

UniProtKB/Swiss-Prot: TXND6_HUMAN, Q86XW9

Tissue specificity: Detected at very low levels in testis, lung and brain

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for NME9 gene from 8/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NDK_CHICK⁶ F1N910_CHICK⁶ (see all 4)	Nucleoside diphosphate kinase (see all 4)	24(a) 24(a) (see all 4)	possible ortholog possible ortholog (see all 4)	18(5062096-5064054) 18(9930932-9933309)
lizard (Anolis carolinensis)	Reptilia	-- --	--	39(a) 14(a)	possible ortholog possible ortholog	6(47767459-47772252) 2(117754712-117771891)
zebrafish (Danio rerio)	Actinopterygii	nme2a⁶ nme3⁶ (see all 6)	non-metastatic cells 3, protein expressed in (see all 6)	25(a) 24(a) (see all 6)	possible ortholog possible ortholog (see all 6)	12(22137915-22148986) 3(15595146-15620149)
fruit fly (Drosophila melanogaster)	Insecta	awd⁶	abnormal wing discs	22(a)	possible ortholog	3R(27570894-27571706)
worm (Caenorhabditis elegans)	Secernentea	ndk-1⁶	Nucleoside diphosphate kinase	25(a)	possible ortholog	I(10553101-10553902)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G23895⁶ AT1G17410⁶ (see all 6)	nucleoside diphosphate kinase-like protein (see all 6)	8(a) 27(a) (see all 6)	possible ortholog 1 ↔ many (see all 6)	4(12422087-12426475) 1(5968534-5969995)
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	nucleoside diphosphate kinase, putative, expressed... nucleoside diphosphate kinase, putative, expressed... (see all 5)	29(a) 26(a) (see all 5)	1 ↔ many possible ortholog (see all 5)	2(21447248-21450026) 7(18333879-18336494)
E. coli (Escherichia coli)	Gamma proteobacteria	ndk⁶	multifunctional nucleoside diphosphate kinase and ...	33(a)	1 → many	Chromosome(2642455-2642886)

ENSEMBL Gene Tree for NME9 (if available)
TreeFam Gene Tree for NME9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NME9 gene

NME1² NME2² NME3² NME8² NME7² NME4² NME1-NME2² NME6²

NME5²

2 SIMAP similar genes for NME9 using alignment to 5 protein entries: TXND6_HUMAN (see all proteins):

TXNDC6 NME8

NME9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186740965^1,2	C	--	138017732(+)	`GGAGGA/GTGATG`	1	--	int¹		0	--	--	--	--
rs114683999^1,2	F,	--	138017799(+)	`TAAGGC/TGAAGA`	1	--	int¹		1		WA	118
rs77844278^1,2	C,F,	--	138017919(+)	`GGCTGA/CCAGAA`	1	--	int¹		1		WA	118
rs138684711^1,2		--	138018217(+)	`AGCCCA/GGCCTG`	1	--	int¹		0	--	--	--	--
rs6439800^1,2	C,F,H,	--	138018341(+)	`CGCCAA/GTGAGT`	1	--	int¹		24		NA NS EA WA CSA	1786
rs141604016^1,2		--	138018399(+)	`CCTTAC/TACCCC`	1	--	int¹		0	--	--	--	--
rs139086644^1,2		--	138018493(+)	`AGTAAC/TGGGAG`	1	--	int¹		0	--	--	--	--
rs141655862^1,2		--	138018574(+)	`CTGCCA/CAGCTA`	1	--	int¹		0	--	--	--	--
rs77995188^1,2	C,	--	138018607(+)	`AACACC/TCCCCG`	1	--	int¹		0	--	--	--	--
rs150511170^1,2		--	138018646(+)	`TTCCCC/TTCTCT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NME9 (137980279 - 138048728 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NME9: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NME9 for disorders About GeneDecksing

4 diseases for NME9: About MalaCards

copd alzheimer's disease colorectal cancer pneumonia

Export disorders for NME9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NME9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NME9)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of human thioredoxin-like 2. A novel microtubule- binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme. (PubMed id 12569107)^{1, 2, 3, 9} Sadek C.M....Miranda-Vizuete A. (2003)
Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)^{1, 3} Desvignes T....Bobe J. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)¹ Furney S.J....Lovestone S. (2010)
Proteomic analysis in lung tissue of smokers and COPD patients. (PubMed id 18753468)¹ Lee E.J....Uhm C.S. (2009)
Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. (PubMed id 16236267)¹ Guo D.... Wang C.-Y. (2005)
The mammalian testis-specific thioredoxin system. (PubMed id 14713334)¹ Miranda-Vizuete A....Oko R. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Identification and distribution of thioredoxin-like 2 as the antigen for the monoclonal antibody MC3 specific to colorectal cancer. (PubMed id 18528843)⁹ Lu Y....Fan D. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 347736	HGNC: 21343	AceView: TXNDC6	Ensembl:ENSG00000181322	euGenes: HUgn347736
ECgene: NME9	H-InvDB: NME9

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NME9	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NME9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NME9 gene:
Search GeneIP for patents involving NME9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	OriGene Antibodies for NME9		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NME9		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NME9
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NME9
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NME9
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NME9
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NME9
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	GenScript Custom Purified and Recombinant Proteins Services for NME9		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for NME9
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	GenScript Custom overexpressing Cell Line Services for NME9		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME9

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ThermoFisher Antibody for NME9

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME9

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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NME9 Gene

NME/NM23 family member 9

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NME9 Gene

NME/NM23 family member 9

Aliasesfor NME9 gene

Summariesfor NME9 gene

Genomic Viewsfor NME9 gene

Proteinsfor NME9 gene

Protein Domains /Familiesfor NME9 gene

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for NME9 gene

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for NME9 gene

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for NME9 gene

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for NME9 gene

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