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Aliases for NME9 Gene

Aliases for NME9 Gene

  • NME/NM23 Family Member 9 2 3
  • Thioredoxin Domain Containing 6 2 3
  • Thioredoxin-Like Protein 2 3 4
  • NME Gene Family Member 9 2 3
  • NME Family Member 9 2 3
  • TXNDC6 3 4
  • TXL-2 3 4
  • TXL2 3 4
  • Thioredoxin Domain-Containing Protein 6 3
  • Thioredoxin-Like 2 3
  • NM23-H9 3

External Ids for NME9 Gene

Previous Symbols for NME9 Gene

  • TXNDC6

Summaries for NME9 Gene

GeneCards Summary for NME9 Gene

NME9 (NME/NM23 Family Member 9) is a Protein Coding gene. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME9 Gene

  • May be a regulator of microtubule physiology

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME9 Gene

Genomics for NME9 Gene

Genomic Location for NME9 Gene

138,261,437 bp from pter
138,330,176 bp from pter
68,740 bases
Minus strand

Genomic View for NME9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NME9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME9 Gene

No data available for Regulatory Elements for NME9 Gene

Proteins for NME9 Gene

  • Protein details for NME9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q7Z4A8
    • Q8N1V7

    Protein attributes for NME9 Gene

    330 amino acids
    Molecular mass:
    36856 Da
    Quaternary structure:
    • Monomer and homodimer
    • Shows no detectable enzyme activity

    Alternative splice isoforms for NME9 Gene


neXtProt entry for NME9 Gene

Proteomics data for NME9 Gene at MOPED

Post-translational modifications for NME9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NME9 Gene

Domains for NME9 Gene


  • Contains 1 thioredoxin domain.:
    • Q86XW9
  • Belongs to the NDK family.:
    • Q86XW9
genes like me logo Genes that share domains with NME9: view

No data available for Gene Families for NME9 Gene

Function for NME9 Gene

Molecular function for NME9 Gene

UniProtKB/Swiss-Prot Function: May be a regulator of microtubule physiology

Gene Ontology (GO) - Molecular Function for NME9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NME9: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NME9 Gene

Localization for NME9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NME9 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for NME9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with NME9: view

Pathways for NME9 Gene

SuperPathways for NME9 Gene

No Data Available

Interacting Proteins for NME9 Gene

Gene Ontology (GO) - Biological Process for NME9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with NME9: view

No data available for Pathways by source for NME9 Gene

Transcripts for NME9 Gene

mRNA/cDNA for NME9 Gene

Unigene Clusters for NME9 Gene

NME/NM23 family member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NME9 Gene

No ASD Table

Relevant External Links for NME9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NME9 Gene

mRNA expression in normal human tissues for NME9 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NME9 Gene

SOURCE GeneReport for Unigene cluster for NME9 Gene Hs.660992

mRNA Expression by UniProt/SwissProt for NME9 Gene

Tissue specificity: Detected at very low levels in testis, lung and brain.
genes like me logo Genes that share expressions with NME9: view

Orthologs for NME9 Gene

This gene was present in the common ancestor of animals.

Orthologs for NME9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NME9 37
  • 94 (a)
  • 99.46 (n)
  • 100 (a)
(Bos Taurus)
Mammalia NME9 36
  • 88.76 (n)
  • 86.35 (a)
NME9 37
  • 60 (a)
(Canis familiaris)
Mammalia NME9 36
  • 87.95 (n)
  • 85.94 (a)
NME9 37
  • 67 (a)
(Mus musculus)
Mammalia 1600029I14Rik 37
  • 80 (a)
Nme9 36
  • 80.79 (n)
  • 79.39 (a)
Nme9 16
(Monodelphis domestica)
Mammalia NME9 37
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia NME9 37
  • 45 (a)
(Rattus norvegicus)
Mammalia Nme9 36
  • 80.93 (n)
  • 80 (a)
(Danio rerio)
Actinopterygii nme8 37
  • 22 (a)
fruit fly
(Drosophila melanogaster)
Insecta nmdyn-D6 37
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 18 (a)
Species with no ortholog for NME9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NME9 Gene

Gene Tree for NME9 (if available)
Gene Tree for NME9 (if available)

Paralogs for NME9 Gene

Paralogs for NME9 Gene

Selected SIMAP similar genes for NME9 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NME9: view

Variants for NME9 Gene

Sequence variations from dbSNP and Humsavar for NME9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3856635 -- 138,303,370(+) GACCT(A/G)TATTT intron-variant
rs3856636 -- 138,306,294(+) TAGAA(G/T)TCATC intron-variant
rs3912163 -- 138,310,818(-) tcttc(A/C)tacgt intron-variant
rs4678406 -- 138,312,597(+) acaaa(C/T)acaaa intron-variant
rs4678407 -- 138,331,843(+) TGGGC(A/C)TGGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NME9 Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914
nsv4030 CNV Insertion 18451855
nsv877537 CNV Gain 21882294
nsv822263 CNV Loss 20364138
nsv822264 CNV Loss 20364138
nsv528349 CNV Loss 19592680

Relevant External Links for NME9 Gene

HapMap Linkage Disequilibrium report

Disorders for NME9 Gene

No disorders were found for NME9 Gene.

No data available for UniProtKB/Swiss-Prot for NME9 Gene

Publications for NME9 Gene

  1. Characterization of human thioredoxin-like 2. A novel microtubule- binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme. (PMID: 12569107) Sadek C.M. … Miranda-Vizuete A. (J. Biol. Chem. 2003) 2 3 4 23
  2. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T. … Bobe J. (BMC Evol. Biol. 2009) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The mammalian testis-specific thioredoxin system. (PMID: 14713334) Miranda-Vizuete A. … Oko R. (Antioxid. Redox Signal. 2004) 3
  5. Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. (PMID: 16236267) Guo D. … Wang C.-Y. (Biochem. Biophys. Res. Commun. 2005) 3

Products for NME9 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NME9
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NME9
    • Block miRNA regulation of NME9 using miScript Target Protectors

    Sources for NME9 Gene

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