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NME9 Gene

protein-coding GIFtS: 42
GCID: GC03M137981

NME/NM23 Family Member 9

(Previous names: thioredoxin domain containing 6, NME gene family member...)
(Previous symbol: TXNDC6)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
NME/NM23 Family Member 9¹ ²		TXL2² ³
TXNDC6¹ ² ³		NM23-H9²
NME Family Member 9¹ ²		TXL-2²
NME Gene Family Member 9¹ ²		Thioredoxin Domain-Containing Protein 6²
Thioredoxin Domain Containing 6¹ ²		Thioredoxin-Like 2²
Thioredoxin-Like Protein 2² ³		Txl-2³

External Ids:	HGNC: 21343¹	Entrez Gene: 347736²	Ensembl: ENSG00000181322⁷	UniProtKB: Q86XW9³

Export aliases for NME9 gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NME9 Gene:

NME9 (NME/NM23 family member 9) is a protein-coding gene. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME2.

UniProtKB/Swiss-Prot: TXND6_HUMAN, Q86XW9

Function: May be a regulator of microtubule physiology

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000003.11 NT_005612.17 NC_018914.2

Regulatory elements:

Search for regulatory transcription factor binding sites for NME9
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NME9 promoter sequence

Search Chromatin IP Primers for NME9

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3 Ensembl cytogenetic band: 3q22.3 HGNC cytogenetic band: 3q22.3

NME9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME9 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M137981: view genomic region (about GC identifiers)

Start:	137,980,279 bp from pter	End:	138,048,728 bp from pter
Size:	68,450 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TXND6_HUMAN, Q86XW9 (See protein sequence)

Recommended Name: Thioredoxin domain-containing protein 6

Size: 330 amino acids; 36856 Da

Subunit: Monomer and homodimer

Miscellaneous: Shows no detectable enzyme activity

Secondary accessions: Q7Z4A8 Q8N1V7

Alternative splicing: 3 isoforms: Q86XW9-1 Q86XW9-2 Q86XW9-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NME9: NX_Q86XW9

Explore proteomics data for NME9 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See NME9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_835231.1

ENSEMBL proteins:

ENSP00000372667 ENSP00000419355 ENSP00000419882 ENSP00000335444 ENSP00000420435

ENSP00000419147 ENSP00000420668 ENSP00000420258 ENSP00000341084 ENSP00000321929

ENSP00000440143

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:

IPR001564 Nucleoside_diP_kinase

IPR012336 Thioredoxin-like_fold

IPR013766 Thioredoxin_domain

IPR017937 Thioredoxin_CS

Graphical View of Domain Structure for InterPro Entry Q86XW9

ProtoNet protein and cluster: Q86XW9

3 Blocks protein domains:

IPB000408 Regulator of chromosome condensation

IPB001564 Nucleoside diphosphate kinase

IPB006662 Thioredoxin type domain

UniProtKB/Swiss-Prot: TXND6_HUMAN, Q86XW9

Similarity: Belongs to the NDK family

Similarity: Contains 1 thioredoxin domain

Find genes that share domains with NME9 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TXND6_HUMAN, Q86XW9

Function: May be a regulator of microtubule physiology

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004550	nucleoside diphosphate kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--

Find genes that share ontologies with NME9 About GenesLikeMe

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TXND6_HUMAN, Q86XW9: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with

microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette (By

similarity)

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--

Find genes that share ontologies with NME9 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for NME9
Interactions:

Search GeneGlobe Interaction Network for NME9

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

Selected Interacting proteins for NME9 (ENSP00000321929⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SUMO4	ENSP00000318635⁴	STRING: ENSP00000318635
GSR	ENSP00000221130⁴	STRING: ENSP00000221130
MSRA	ENSP00000313921⁴	STRING: ENSP00000313921
NSF	ENSP00000381293⁴	STRING: ENSP00000381293
PRDX5	ENSP00000265462⁴	STRING: ENSP00000265462

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006165	nucleoside diphosphate phosphorylation	--	--
GO:0006183	GTP biosynthetic process	IEA	--
GO:0006228	UTP biosynthetic process	IEA	--
GO:0006241	CTP biosynthetic process	IEA	--
GO:0045454	cell redox homeostasis	IEA	--

Find genes that share ontologies with NME9 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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Browse Tocris compounds for NME9 (TXND6)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NME9 gene:

NM_178130.2

Unigene Cluster for NME9:

NME/NM23 family member 9

Hs.660992 [show with all ESTs]

Unigene Representative Sequence: NM_178130

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000383180(uc003ese.1) ENST00000492993 ENST00000484930 ENST00000333911(uc003esg.3)

ENST00000474690 ENST00000478220 ENST00000475751 ENST00000488716 ENST00000460099

ENST00000341790 ENST00000317876(uc003esd.1 uc010huf.1) ENST00000536478

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Additional mRNA sequence:

AF196568.1 AK094830.1 AY336746.1 BC107054.2

6 DOTS entries:

DT.75119193 DT.40113384 DT.65286059 DT.91703436 DT.91998524 DT.92415449

15 AceView cDNA sequences:

NM_178130 CA868240 AK094830 AI611656 AF196568 BF736559 CA867993 BG570189

BU607430 AY336746 CA312568 BE673422 BF850566 CD699916 AW869049

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NME9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTTTTGCTGT

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NME9 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NME9 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.660992

UniProtKB/Swiss-Prot: TXND6_HUMAN, Q86XW9

Tissue specificity: Detected at very low levels in testis, lung and brain

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NME9 gene from Selected species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nme9^{1 , 5}	thioredoxin domain containing 6⁵ NME/NM23 family member 9¹	80.79(n)¹ 79.39(a)¹		9 (51.72 cM)⁵ 623534¹ NM_001165957.1¹ NP_001159429.1¹ 99456243⁵
zebrafish (Danio rerio)	Actinopterygii	nme8⁶	NME/NM23 family member 8	22(a)	1 ↔ 1	9(54049364-54120095) ENSDARG00000076395
fruit fly (Drosophila melanogaster)	Insecta	nmdyn-D6⁶	nmdyn-D6	17(a)	1 → many	X(14477710-14478649)

ENSEMBL Gene Tree for NME9 (if available)
TreeFam Gene Tree for NME9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for NME9 gene

NME2² NME1² NME3² NME8² NME4² NME7² NME1-NME2² NME6²

NME5²

2 SIMAP similar genes for NME9 using alignment to 5 protein entries: TXND6_HUMAN (see all proteins):

TXNDC6 NME8

Find genes that share paralogs with NME9 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186740965^1,2	C	--	138017732(+)	`GGAGGA/GTGATG`	1	--	int¹		0	--	--	--	--
rs114683999^1,2	C,F	--	138017799(+)	`TAAGGC/TGAAGA`	1	--	int¹		1		WA	118
rs77844278^1,2	C,F	--	138017919(+)	`GGCTGA/CCAGAA`	1	--	int¹		1		WA	118
rs138684711^1,2		--	138018217(+)	`AGCCCA/GGCCTG`	1	--	int¹		0	--	--	--	--
rs6439800^1,2	C,F,H	--	138018341(+)	`CGCCAA/GTGAGT`	1	--	int¹		24		NA NS EA WA CSA	1786
rs141604016^1,2		--	138018399(+)	`CCTTAC/TACCCC`	1	--	int¹		0	--	--	--	--
rs139086644^1,2		--	138018493(+)	`AGTAAC/TGGGAG`	1	--	int¹		0	--	--	--	--
rs141655862^1,2	C	--	138018574(+)	`CTGCCA/CAGCTA`	1	--	int¹		0	--	--	--	--
rs77995188^1,2	C	--	138018607(+)	`AACACC/TCCCCG`	1	--	int¹		0	--	--	--	--
rs150511170^1,2		--	138018646(+)	`TTCCCC/TTCTCT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NME9 (137980279 - 138048728 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for NME9: About this table

Variant ID	Type	Subtype	PubMed ID
nsv4030	CNV	Insertion	18451855
nsv528349	CNV	Loss	19592680
nsv822263	CNV	Loss	20364138
nsv822264	CNV	Loss	20364138
nsv877537	CNV	Gain	21882294
nsv428422	CNV	Gain+Loss	18775914

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing NME9

DNA2.0 Custom Variant and Variant Library Synthesis for NME9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NME9 gene integrated from 10 sources:
(articles sorted by number of sources associating them with NME9)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of human thioredoxin-like 2. A novel microtubule- binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme. (PubMed id 12569107)^{1, 2, 3, 9} Sadek C.M....Miranda-Vizuete A. (J. Biol. Chem. 2003)
Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)^{1, 3} Desvignes T....Bobe J. (BMC Evol. Biol. 2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Thioredoxin-like protein 2 is overexpressed in colon cancer and promotes cancer cell metastasis by interaction with ran. (PubMed id 23311631)¹ Lu Y....Fan D. (amp 2013)
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)¹ Furney S.J.... . (Mol. Psychiatry 2011)
Proteomic analysis in lung tissue of smokers and COPD patients. (PubMed id 18753468)¹ Lee E.J....Uhm C.S. (Chest 2009)
Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. (PubMed id 16236267)¹ Guo D.... Wang C.-Y. (Biochem. Biophys. Res. Commun. 2005)
The mammalian testis-specific thioredoxin system. (PubMed id 14713334)¹ Miranda-Vizuete A....Oko R. (amp 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Identification and distribution of thioredoxin-like 2 as the antigen for the monoclonal antibody MC3 specific to colorectal cancer. (PubMed id 18528843)⁹ Lu Y....Fan D. (Proteomics 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 347736	HGNC: 21343	AceView: TXNDC6	Ensembl:ENSG00000181322	euGenes: HUgn347736
ECgene: NME9	H-InvDB: NME9

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NME9	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NME9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NME9 gene:
Search GeneIP for patents involving NME9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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	OriGene Antibodies for NME9		OriGene RNAi products in human, mouse, rat for NME9
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	Block miRNA regulation of human, mouse, rat NME9 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing NME9
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME9		Predesigned siRNA for gene silencing in human, mouse, rat NME9
	QuantiFast Probe-based Assays in human, mouse, rat NME9		QuantiTect SYBR Green Assays in human, mouse, rat NME9
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	GenScript Custom Purified and Recombinant Proteins Services for NME9		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for NME9
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME9

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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

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NME9 Gene

NME/NM23 Family Member 9

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NME9 Gene

NME/NM23 Family Member 9

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