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NME8 Gene

protein-coding   GIFtS: 42
GCID: GC07P037889

NME/NM23 Family Member 8

(Previous name: thioredoxin domain containing 3 (spermatozoa))
(Previous symbol: TXNDC3)
  See NME8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NME/NM23 Family Member 81 2 3     CILD62 5
TXNDC31 2 3 5     sptrx-22
SPTRX22 3 5     Thioredoxin Domain-Containing Protein 32
Thioredoxin Domain Containing 3 (Spermatozoa)1 2     Sptrx-23
Sperm-Specific Thioredoxin 21 2     EC 2.1.1.318
Spermatid-Specific Thioredoxin-22 3     EC 2.5.1.68
NM23-H82 3     

External Ids:    HGNC: 164731   Entrez Gene: 513142   Ensembl: ENSG000000862887   OMIM: 6074215   UniProtKB: Q8N4273   

Export aliases for NME8 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NME8 Gene:
This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate
kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of
this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function.
Mutations in this gene are implicated in primary ciliary dyskinesia type 6.(provided by RefSeq, Nov 2009)

GeneCards Summary for NME8 Gene:
NME8 (NME/NM23 family member 8) is a protein-coding gene. Diseases associated with NME8 include ciliary dyskinesia, primary, 6, and primary ciliary dyskinesia 6: nme8-related primary ciliary dyskinesia. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME2.

UniProtKB/Swiss-Prot: TXND3_HUMAN, Q8N427
Function: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis,
where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of
disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on
disulfide bonds

Gene Wiki entry for NME8 (TXNDC3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for NME8
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NME8 promoter sequence
   Search Chromatin IP Primers for NME8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.1   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p15.2

NME8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME8 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P037889:  view genomic region     (about GC identifiers)

Start:
37,888,199 bp from pter      End:
37,940,003 bp from pter
Size:
51,805 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 37,926,134-37,977,903     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TXND3_HUMAN, Q8N427 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 3  
Size: 588 amino acids; 67270 Da
Subunit: Monomer
Developmental stage: Restricted to spermiogenesis, starting at the pachytene spermatocyte level and peaking at the
round and elongating spermatid stage
Secondary accessions: Q9NZH1

Explore the universe of human proteins at neXtProt for NME8: NX_Q8N427

Explore proteomics data for NME8 at MOPED

2 DME Specific Peptides for NME8 (Q8N427)
 KEVVNRL  ILKIVKE 


See NME8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_057700.3  
ENSEMBL proteins: 
 ENSP00000199447   ENSP00000390047   ENSP00000390596   ENSP00000397063   ENSP00000408841  

NME8 Human Recombinant Protein Products:

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Novus Biologicals NME8 Proteins
Novus Biologicals NME8 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for NME8 

 
antibodies-online proteins for NME8 (6 products) 

 
antibodies-online peptides for NME8

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antibodies-online antibodies for NME8 (15 products) 

NME8 Assay Products:

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Search eBioscience for ELISAs for NME8 
antibodies-online kits for NME8 (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR001564 Nucleoside_diP_kinase
 IPR012336 Thioredoxin-like_fold
 IPR013766 Thioredoxin_domain
 IPR017937 Thioredoxin_CS

Graphical View of Domain Structure for InterPro Entry Q8N427

ProtoNet protein and cluster: Q8N427

2 Blocks protein domains:
IPB001564 Nucleoside diphosphate kinase
IPB006662 Thioredoxin type domain


UniProtKB/Swiss-Prot: TXND3_HUMAN, Q8N427
Domain: Contains 3 inactive NDK domains that each lack the active His residue, suggesting that they have no NDP
kinase activity
Similarity: In the C-terminal section; belongs to the NDK family
Similarity: Contains 1 thioredoxin domain


Find genes that share domains with NME8           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TXND3_HUMAN, Q8N427
Function: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis,
where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of
disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on
disulfide bonds

     Enzyme Numbers (IUBMB): EC 2.1.1.312 EC 2.5.1.62

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004550nucleoside diphosphate kinase activity IEA--
GO:0005524ATP binding IEA--
     
Find genes that share ontologies with NME8           About GenesLikeMe


Phenotypes:
     5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nme8):
 cellular  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  reproductive system 

Find genes that share phenotypes with NME8           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Nme8tm1.1Arte for NME8

   genOway: Develop your customized and physiologically relevant rodent model for NME8

miRNA
Products:
    
miRTarBase miRNAs that target NME8:
hsa-mir-484 (MIRT041630)

Block miRNA regulation of human, mouse, rat NME8 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate NME8
SwitchGear 3'UTR luciferase reporter plasmidNME8 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat NME8

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME8
Addgene plasmids for NME8 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME8


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TXND3_HUMAN, Q8N427: Cytoplasm

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--
GO:0015630microtubule cytoskeleton ----

Find genes that share ontologies with NME8           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NME8
Interactions:

    Search GeneGlobe Interaction Network for NME8

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

Selected Interacting proteins for NME8 (ENSP000001994474) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
InteractantInteraction Details
GeneCardExternal ID(s)
GSRENSP000002211304STRING: ENSP00000221130
MSRAENSP000003139214STRING: ENSP00000313921
NSFENSP000003812934STRING: ENSP00000381293
PRDX5ENSP000002654624STRING: ENSP00000265462
POLR1BENSP000002633314STRING: ENSP00000263331
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Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006165nucleoside diphosphate phosphorylation ----
GO:0006183GTP biosynthetic process IEA--
GO:0006228UTP biosynthetic process IEA--
GO:0006241CTP biosynthetic process IEA--
GO:0007275multicellular organismal development IEA--

Find genes that share ontologies with NME8           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NME8 (TXND3)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NME8 gene: 
NM_016616.4  

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000199447(uc003tfn.3) ENST00000455500 ENST00000444718 ENST00000440017
ENST00000426106 ENST00000476435
miRNA
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Inhib. RNA
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME8
Addgene plasmids for NME8 
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for NME8
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat NME8
  QuantiTect SYBR Green Assays in human, mouse, rat NME8
  QuantiFast Probe-based Assays in human, mouse, rat NME8

21 AceView cDNA sequences:

AF305596 NM_181791 AY288420 AY255538 BG221739 AF202051 BX952455 AI077399 
BC036816 NM_016616 BF896644 AI375144 BC043356 AW590130 BP371009 BM908078 
AL598654 AL043096 BU570921 CD699779 BX115172 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for NME8    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1:                                                                                                      
SP2:        -     -           -     -     -     -     -     -                                             


ECgene alternative splicing isoforms for NME8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NME8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
NME8 Expression
About this image


NME8 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Pancreas (Endocrine System)
         Islets of Langerhans
 
 Testis (Reproductive System)
         Leydig Cells Testis Interstitium
 
 Brain (Nervous System)
         Cerebral Cortex
NME8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NME8 Protein Expression

UniProtKB/Swiss-Prot: TXND3_HUMAN, Q8N427
Tissue specificity: Testis-specific. Expressed only in primary spermatocytes and round spermatids

    Custom PCR Arrays for NME8
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NME8 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nme81 , 5 thioredoxin domain containing 3 (spermatozoa)5
NME/NM23 family member 81
74.27(n)1
63.9(a)1
  13 (7.00 cM)5
734121  NM_181591.31  NP_853622.21 
 196450785 
chicken
(Gallus gallus)
Aves TXNDC31 thioredoxin domain containing 3 (spermatozoa) 61.03(n)
49.47(a)
  428461  XM_426021.4  XP_426021.3 
lizard
(Anolis carolinensis)
Reptilia NME86
NME/NM23 family member 8
48(a)
1 ↔ 1
6(47767459-47772252)
tropical clawed frog
(Xenopus tropicalis)
Amphibia nme91 NME/NM23 family member 9 51.9(n)
40.95(a)
  100158550  NM_001127984.1  NP_001121456.1 
zebrafish
(Danio rerio)
Actinopterygii nme81 NME/NM23 family member 8 48.25(n)
38.91(a)
  100037319  NM_001089475.1  NP_001082944.1 
fruit fly
(Drosophila melanogaster)
Insecta nmdyn-D66
nmdyn-D6
27(a)
1 → many
X(14477710-14478649)


ENSEMBL Gene Tree for NME8 (if available)
TreeFam Gene Tree for NME8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NME8 gene
NME22  NME12  NME32  NME42  NME72  NME1-NME22  NME62  NME92  
NME52  
2 SIMAP similar genes for NME8 using alignment to 4 protein entries:     TXND3_HUMAN (see all proteins):
NME5    NME9

Find genes that share paralogs with NME8           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NME8 (see all 1466)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0361714
A breast cancer sample4--see VAR_0361712 I T mis40--------
rs2017033141,2
Cuntested137943098(+) CATAAA/G/TACAGT 2 K syn10--------
rs624593171,2
C--37858850(+) CATGTA/GTGTTT 1 -- us2k10--------
rs752011851,2
C,F--37858962(+) CTATGC/TAGCCA 1 -- us2k12Minor allele frequency- T:0.50NA 4
rs798173871,2
C,F--37858978(+) AACGAC/TGAGTT 1 -- us2k13Minor allele frequency- T:0.18NA 124
rs744548021,2
C,F--37858987(+) TTCATG/ATTTTT 1 -- us2k12Minor allele frequency- A:0.50NA 4
rs1503368781,2
C--37859002(+) GGGACA/GTGGAT 1 -- us2k10--------
rs114156551,2
C--37886447(+) AAAAA-/AGGAAA 1 -- us2k1 trp30--------
rs2014476671,2
C--37889482(+) AAAAA-/CAAAAA 1 -- int10--------
rs25980451,2
C--37889488(-) CTTTTG/TTTTTT 1 -- int1 trp33Minor allele frequency- T:0.20WA NA CSA 5

HapMap Linkage Disequilibrium report for NME8 (37888199 - 37940003 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for NME8: --
Human Gene Mutation Database (HGMD): NME8
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing NME8
DNA2.0 Custom Variant and Variant Library Synthesis for NME8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607421   
OMIM disorders: 610852  
UniProtKB/Swiss-Prot: TXND3_HUMAN, Q8N427
  • Ciliary dyskinesia, primary, 6 (CILD6) [MIM:610852]: A disorder characterized by abnormalities of motile
    cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in
    the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails.
    Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of
    monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as
    Kartagener syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for NME8:    
    About MalaCards
    ciliary dyskinesia, primary, 6    primary ciliary dyskinesia 6: nme8-related primary ciliary dyskinesia    ciliary dyskinesia, primary, 19    primary ciliary dyskinesia


    Find genes that share disorders with NME8           About GenesLikeMe


    Export disorders for NME8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NME8 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with NME8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells. (PubMed id 11737268)1, 2, 3, 9 Sadek C.M.... Miranda-Vizuete A. (Genes Cells 2001)
    2. The human Nm23/nucleoside diphosphate kinases. (PubMed id 11768308)1, 2, 3 Lacombe M.-L.L.... Lambeth D.O. (J. Bioenerg. Biomembr. 2000)
    3. Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)1, 3 Desvignes T....Bobe J. (BMC Evol. Biol. 2009)
    4. A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia. (PubMed id 17360648)1, 2 Duriez B.... Amselem S. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PubMed id 22504420)1 Estrada K....Rivadeneira F. (Nat. Genet. 2012)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system. (PubMed id 20237151)1 Zintzaras E....Karachalios T. (Am. J. Epidemiol. 2010)
    10. Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis. (PubMed id 18471322)1 Shi D....Jiang Q. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51314 HGNC: 16473 AceView: TXNDC3andGPR141 Ensembl:ENSG00000086288 euGenes: HUgn51314
    ECgene: NME8 H-InvDB: NME8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NME8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NME8 gene:
    Search GeneIP for patents involving NME8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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