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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NME8 Gene

protein-coding   GIFtS: 45
GCID: GC07P037889

NME/NM23 Family Member 8

(Previous name: thioredoxin domain containing 3 (spermatozoa))
(Previous symbol: TXNDC3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NME/NM23 Family Member 81 2 3     CILD62 5
TXNDC31 2 3 5     sptrx-22
SPTRX22 3 5     Thioredoxin Domain-Containing Protein 32
Thioredoxin Domain Containing 3 (Spermatozoa)1 2     Sptrx-23
Sperm-Specific Thioredoxin 21 2     EC 2.1.1.318
Spermatid-Specific Thioredoxin-22 3     EC 2.5.1.68
NM23-H82 3     

External Ids:    HGNC: 164731   Entrez Gene: 513142   Ensembl: ENSG000000862887   OMIM: 6074215   UniProtKB: Q8N4273   

Export aliases for NME8 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NME8 Gene:
This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate
kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of
this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function.
Mutations in this gene are implicated in primary ciliary dyskinesia type 6.(provided by RefSeq, Nov 2009)

GeneCards Summary for NME8 Gene: 
NME8 (NME/NM23 family member 8) is a protein-coding gene. Diseases associated with NME8 include ciliary dyskinesia, primary, 6, and primary ciliary dyskinesia 6: nme8-related primary ciliary dyskinesia. GO annotations related to this gene include nucleoside diphosphate kinase activity and ATP binding. An important paralog of this gene is NME2.

UniProtKB/Swiss-Prot: TXND3_HUMAN, Q8N427
Function: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis,
where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of
disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on
disulfide bonds

Gene Wiki entry for NME8 (TXNDC3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NME8
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NME8 promoter sequence
   Search SABiosciences Chromatin IP Primers for NME8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NME8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.1   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p15.2

NME8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME8 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P037889:  view genomic region     (about GC identifiers)

Start:
37,888,199 bp from pter      End:
37,940,003 bp from pter
Size:
51,805 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 37,926,134-37,977,903     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TXND3_HUMAN, Q8N427 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 3  
Size: 588 amino acids; 67270 Da
Subunit: Monomer
Subcellular location: Cytoplasm
Developmental stage: Restricted to spermiogenesis, starting at the pachytene spermatocyte level and peaking at the
round and elongating spermatid stage
Secondary accessions: Q9NZH1

Explore the universe of human proteins at neXtProt for NME8: NX_Q8N427

Explore proteomics data for NME8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N427

  • 2 DME Specific Peptides for NME8 (Q8N427)
     KEVVNRL  ILKIVKE 

    NME8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NME8 Protein Expression
    REFSEQ proteins: NP_057700.3  
    ENSEMBL proteins: 
     ENSP00000199447   ENSP00000390047   ENSP00000390596   ENSP00000397063   ENSP00000408841  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0015630microtubule cytoskeleton IDA--

    NME8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001564 Nucleoside_diP_kinase
     IPR012336 Thioredoxin-like_fold
     IPR013766 Thioredoxin_domain
     IPR017937 Thioredoxin_CS

    Graphical View of Domain Structure for InterPro Entry Q8N427

    ProtoNet protein and cluster: Q8N427

    2 Blocks protein domains:
    IPB001564 Nucleoside diphosphate kinase
    IPB006662 Thioredoxin type domain


    UniProtKB/Swiss-Prot: TXND3_HUMAN, Q8N427
    Domain: Contains 3 inactive NDK domains that each lack the active His residue, suggesting that they have no NDP
    kinase activity
    Similarity: In the C-terminal section; belongs to the NDK family
    Similarity: Contains 1 thioredoxin domain


    NME8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXND3_HUMAN, Q8N427
    Function: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis,
    where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of
    disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on
    disulfide bonds

         Enzyme Numbers (IUBMB): EC 2.1.1.312 EC 2.5.1.62

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004550nucleoside diphosphate kinase activity IEA--
    GO:0005524ATP binding IEA--
         
    NME8 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NME8

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006165nucleoside diphosphate phosphorylation ----
    GO:0006183GTP biosynthetic process IEA--
    GO:0006228UTP biosynthetic process IEA--
    GO:0006241CTP biosynthetic process IEA--
    GO:0007275multicellular organismal development IEA--

    NME8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NME8 (TXND3)

    Search CenterWatch for drugs/clinical trials and news about NME8 / TXND3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NME8 gene: 
    NM_016616.4  

    Unigene Cluster for NME8:

    NME/NM23 family member 8
    Hs.723454  [show with all ESTs]
    Unigene Representative Sequence: BC036816
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000199447(uc003tfn.3) ENST00000455500 ENST00000444718 ENST00000440017
    ENST00000426106 ENST00000476435
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF202051.2 AF305596.1 AK313599.1 BC036816.1 

    2 DOTS entries:

    DT.65288377  DT.40230636 

    21 AceView cDNA sequences:

    NM_181791 AF202051 AY255538 AF305596 BG221739 AY288420 BF896644 AL043096 
    BC036816 AI077399 BP371009 NM_016616 AW590130 BC043356 AL598654 BX952455 
    AI375144 BM908078 BU570921 CD699779 BX115172 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NME8    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
    SP1:                                                                                                      
    SP2:        -     -           -     -     -     -     -     -                                             


    ECgene alternative splicing isoforms for NME8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NME8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NME8 Expression
    About this image


    See NME8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NME8

    SOURCE GeneReport for Unigene cluster: Hs.723454

    UniProtKB/Swiss-Prot: TXND3_HUMAN, Q8N427
    Tissue specificity: Testis-specific. Expressed only in primary spermatocytes and round spermatids

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NME8 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nme81 , 5 thioredoxin domain containing 3 (spermatozoa)5
    NME/NM23 family member 81
    74.13(n)1
    63.68(a)1
      13 (7.00 cM)5
    734121  NM_181591.31  NP_853622.21 
     196450785 
    chicken
    (Gallus gallus)
    Aves TXNDC31 thioredoxin domain containing 3 (spermatozoa) 61.03(n)
    49.47(a)
      428461  XM_426021.3  XP_426021.3 
    lizard
    (Anolis carolinensis)
    Reptilia NME86
    Uncharacterized protein
    41(a)
    1 ↔ 1
    6(47767459-47772252)
    zebrafish
    (Danio rerio)
    Actinopterygii nme81 NME/NM23 family member 8 48.42(n)
    38.99(a)
      100037319  NM_001089475.1  NP_001082944.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nmdyn-D66
    nmdyn-D6
    26(a)
    1 → many
    X(14477710-14478649)


    ENSEMBL Gene Tree for NME8 (if available)
    TreeFam Gene Tree for NME8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NME8 gene
    NME22  NME12  NME32  NME42  NME72  NME1-NME22  NME62  NME92  
    NME52  
    2 SIMAP similar genes for NME8 using alignment to 4 protein entries:     TXND3_HUMAN (see all proteins):
    NME5    NME9

    NME8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1466 SNPs in NME8 are shown (see all 1466)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361714
    A breast cancer sample4--see VAR_0361712 I T mis40--------
    rs2017033141,2
    Cuntested137943098(+) CATAAA/G/TACAGT 2 K syn10--------
    rs624593171,2
    C--37858850(+) CATGTA/GTGTTT 1 -- us2k10--------
    rs752011851,2
    C,F--37858962(+) CTATGC/TAGCCA 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs798173871,2
    C,F--37858978(+) AACGAC/TGAGTT 1 -- us2k13Minor allele frequency- T:0.18NA 124
    rs744548021,2
    C,F--37858987(+) TTCATG/ATTTTT 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1503368781,2
    C--37859002(+) GGGACA/GTGGAT 1 -- us2k10--------
    rs114156551,2
    C--37886447(+) AAAAA-/AGGAAA 1 -- us2k1 trp30--------
    rs2014476671,2
    C--37889482(+) AAAAA-/CAAAAA 1 -- int10--------
    rs25980451,2
    C--37889488(-) CTTTTG/TTTTTT 1 -- int1 trp33Minor allele frequency- T:0.20WA NA CSA 5

    HapMap Linkage Disequilibrium report for NME8 (37888199 - 37940003 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NME8: --

    Human Gene Mutation Database (HGMD): NME8
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NME8
    DNA2.0 Custom Variant and Variant Library Synthesis for NME8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607421   
    OMIM disorders: 610852  
    UniProtKB/Swiss-Prot: TXND3_HUMAN, Q8N427
  • Primary ciliary dyskinesia 6 (CILD6) [MIM:610852]: A disorder characterized by abnormalities of motile
    cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in
    the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails.
    Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of
    monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as
    Kartagener syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 8 diseases for NME8:    About MalaCards
    ciliary dyskinesia, primary, 6    primary ciliary dyskinesia 6: nme8-related primary ciliary dyskinesia    primary ciliary dyskinesia    kartagener syndrome
    situs inversus    bronchiectasis    osteoarthritis    pneumonia


    NME8 for disorders           About GeneDecksing


    Export disorders for NME8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NME8 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with NME8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells. (PubMed id 11737268)1, 2, 3, 9 Sadek C.M.... Miranda-Vizuete A. (2001)
    2. The human Nm23/nucleoside diphosphate kinases. (PubMed id 11768308)1, 2, 3 Lacombe M.-L.L.... Lambeth D.O. (2000)
    3. Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)1, 3 Desvignes T....Bobe J. (2009)
    4. A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia. (PubMed id 17360648)1, 2 Duriez B.... Amselem S. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Genome-wide meta-analysis identifies 56 bone mineral d ensity loci and reveals 14 loci associated with risk of fracture. (PubMed id 22504420)1 Estrada K....Rivadeneira F. (2012)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Field synopsis and synthesis of genetic association s tudies in osteoarthritis: the CUMAGAS-OSTEO information system. (PubMed id 20237151)1 Zintzaras E....Karachalios T. (2010)
    10. Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis. (PubMed id 18471322)1 Shi D....Jiang Q. (2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51314 HGNC: 16473 AceView: TXNDC3andGPR141 Ensembl:ENSG00000086288 euGenes: HUgn51314
    ECgene: NME8 H-InvDB: NME8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NME8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NME8 gene:
    Search GeneIP for patents involving NME8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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