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NME7 Gene

protein-coding   GIFtS: 59
GCID: GC01M169101

NME/NM23 Family Member 7

(Previous names: non-metastatic cells 7, protein expressed in (nucleoside-diphosphate...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NME/NM23 Family Member 71 2     EC 2.7.4.63 8
Non-Metastatic Cells 7, Protein Expressed In (Nucleoside-Diphosphate
Kinase)1 2
     MN23H72 5
NDK 72 3     NDK72
NDP Kinase 72 3     Nucleoside Diphosphate Kinase 72
nm23-H72 3     Nucleoside-Diphosphate Kinase 72

External Ids:    HGNC: 204611   Entrez Gene: 299222   Ensembl: ENSG000001431567   OMIM: 6134655   UniProtKB: Q9Y5B83   

Export aliases for NME7 gene to outside databases

Previous GC identifers: GC01P166788 GC01M164752 GC01M165797 GC01M166289 GC01M165833 GC01M167368 GC01M140347


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NME7 Gene:
NME7 (NME/NM23 family member 7) is a protein-coding gene. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME2.

UniProtKB/Swiss-Prot: NDK7_HUMAN, Q9Y5B8
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is
transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NME7 gene promoter:
         STAT1   p53   Nkx2-2   STAT1beta   CUTL1   STAT1alpha   Egr-2   COMP1   En-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNME7 promoter sequence
   Search Chromatin IP Primers for NME7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q24.2

NME7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M169101:  view genomic region     (about GC identifiers)

Start:
169,101,769 bp from pter      End:
169,337,205 bp from pter
Size:
235,437 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NDK7_HUMAN, Q9Y5B8 (See protein sequence)
Recommended Name: Nucleoside diphosphate kinase 7  
Size: 376 amino acids; 42492 Da
Cofactor: Magnesium (By similarity)
Secondary accessions: A8K3T6 A8MY09 B3KSW9 Q5TGZ4
Alternative splicing: 2 isoforms:  Q9Y5B8-1   Q9Y5B8-2   

Explore the universe of human proteins at neXtProt for NME7: NX_Q9Y5B8

Explore proteomics data for NME7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys51
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for NME7 (Q9Y5B8)
     NELIQFIT  DYGDQYTARQLGS  AAREMELFFPSSG 


    See NME7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_037462.1  NP_932076.1  

    ENSEMBL proteins: 
     ENSP00000433341   ENSP00000356785   ENSP00000431467   ENSP00000432753  

    NME7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for NME7
    OriGene Protein Over-expression Lysate for NME7
    OriGene MassSpec for NME7
    OriGene Custom Protein Services for NME7
    GenScript Custom Purified and Recombinant Proteins Services for NME7
    Novus Biologicals NME7 Proteins
    Novus Biologicals NME7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NME7

     
    Search eBioscience for Proteins for NME7 

     
    antibodies-online proteins for NME7 (10 products) 

     
    antibodies-online peptides for NME7

    NME7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for NME7
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    antibodies-online antibodies for NME7 (24 products) 

    NME7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NME7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NME7
    Cloud-Clone Corp. CLIAs for NME7
    Search eBioscience for ELISAs for NME7 
    antibodies-online kits for NME7 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR006602 Uncharacterised_DM10
     IPR001564 Nucleoside_diP_kinase
     IPR011410 NDK7

    Graphical View of Domain Structure for InterPro Entry Q9Y5B8

    ProtoNet protein and cluster: Q9Y5B8

    2 Blocks protein domains:
    IPB001564 Nucleoside diphosphate kinase
    IPB006602 Protein of unknown function DM10


    UniProtKB/Swiss-Prot: NDK7_HUMAN, Q9Y5B8
    Similarity: Belongs to the NDK family
    Similarity: Contains 1 DM10 domain


    Find genes that share domains with NME7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDK7_HUMAN, Q9Y5B8
    Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is
    transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
    Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

         Enzyme Number (IUBMB): EC 2.7.4.61 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004550nucleoside diphosphate kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with NME7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NME7:
     Decreased Salmonella enterica  

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nme7):
     behavior/neurological  craniofacial  growth/size/body  nervous system  reproductive system 
     respiratory system  skeleton 

    Find genes that share phenotypes with NME7           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NME7

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NME7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NME7 (see all 12):
    hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-19b hsa-miR-454 hsa-miR-4295 hsa-miR-3908 hsa-miR-130a
    SwitchGear 3'UTR luciferase reporter plasmidNME7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NME7
    Predesigned siRNA for gene silencing in human, mouse, rat NME7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NME7

    Clone
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    OriGene clones in human, mouse for NME7 (see all 12)
    OriGene ORF clones in mouse, rat for NME7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NME7 (NM_013330)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME7
    Addgene plasmids for NME7 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NME7
    Browse ESI BIO Cell Lines and PureStem Progenitors for NME7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--

    Find genes that share ontologies with NME7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NME7 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    Pyrimidine metabolism0.38
    purine deoxyribonucleosides salvage0.00
    2superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
    adenosine deoxyribonucleotides de novo biosynthesis0.00
    guanosine deoxyribonucleotides de novo biosynthesis0.52
    pyrimidine deoxyribonucleotides de novo biosynthesis0.00
    superpathway of pyrimidine deoxyribonucleoside salvage0.46
    UTP and CTP de novo biosynthesis0.00
    CMP phosphorylation0.00
    superpathway of pyrimidine ribonucleotides de novo biosynthesis0.00
    3purine nucleotide salvage
    purine nucleotide salvage0.78
    guanosine nucleotides de novo biosynthesis0.00
    purine nucleotides de novo biosynthesis0.78
    guanosine ribonucleotides de novo biosynthesis0.00
    4Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with NME7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NME7
        ATP/ITP metabolism

    Selected BioSystems Pathways for NME7 (see all 15)
        purine nucleotides de novo biosynthesis
    superpathway of pyrimidine ribonucleotides de novo biosynthesis
    purine deoxyribonucleosides salvage
    guanosine nucleotides de novo biosynthesis
    purine nucleotide salvage


    3 Kegg Pathways  (Kegg details for NME7):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NME7
    Interactions:

        Search GeneGlobe Interaction Network for NME7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NME7 (Q9Y5B82, 3 ENSP000003567854) via UniProtKB, MINT, STRING, and/or I2D (see all 115)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT18P057832, 3, ENSP000003734874MINT-68025 I2D: score=5 STRING: ENSP00000373487
    LINC00921O149782, 3MINT-68026 I2D: score=5 
    ZNF263O149782, 3, ENSP000002190694MINT-68026 I2D: score=5 STRING: ENSP00000219069
    NT5C2P499022, 3, ENSP000003394794MINT-67114 I2D: score=5 STRING: ENSP00000339479
    TCHPQ9BT922, 3, ENSP000003244044MINT-67218 I2D: score=5 STRING: ENSP00000324404
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003351epithelial cilium movement IEA--
    GO:0006165nucleoside diphosphate phosphorylation ----
    GO:0006183GTP biosynthetic process IEA--
    GO:0006228UTP biosynthetic process IEA--
    GO:0006241CTP biosynthetic process IEA--

    Find genes that share ontologies with NME7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NME7 (NDK7)

    Selected HMDB Compounds for NME7 (see all 21)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2'-Deoxyinosine triphosphate2'-Deoxyinosine-5'-triphosphate (see all 6)16595-02-1--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CDPCDP (see all 3)63-38-7--
    Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--
    Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NME7 gene (2 alternative transcripts): 
    NM_013330.4  NM_197972.2  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530739 ENST00000493481 ENST00000472647 ENST00000367811(uc001gft.3 uc001gfu.3)
    ENST00000525440(uc010plq.2) ENST00000483228 ENST00000528517 ENST00000480478
    ENST00000524967(uc001gfv.1) ENST00000469474 ENST00000485609 ENST00000472984
    ENST00000491225 ENST00000527460
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NME7 (see all 12):
    hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-19b hsa-miR-454 hsa-miR-4295 hsa-miR-3908 hsa-miR-130a
    SwitchGear 3'UTR luciferase reporter plasmidNME7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NME7
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NME7 (NM_013330)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME7
    Addgene plasmids for NME7 
    Primer
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    OriGene qPCR primer pairs and template standards for NME7
    OriGene qSTAR qPCR primer pairs in human, mouse for NME7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NME7
      QuantiTect SYBR Green Assays in human, mouse, rat NME7
      Search QuantiFast Probe-based Assays in human, mouse, rat NME7

    Selected AceView cDNA sequences (see all 166):

    C75275 AA825320 N91931 AW173786 AA902855 BQ631375 BG200642 BM717235 
    AA855143 NM_197972 AK094513 BU726084 W32410 AA911486 AF153191 AA938584 
    AW575122 NM_013330 AA885915 BM669277 BC006983 AA910245 W32856 AI621117 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NME7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTTGCAC
    NME7 Expression
    About this image


    NME7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Lung (Respiratory System)
             Trachea
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
    NME7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NME7 Protein Expression
        Custom PCR Arrays for NME7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NME7
    OriGene qSTAR qPCR primer pairs in human, mouse for NME7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NME7
    QuantiTect SYBR Green Assays in human, mouse, rat NME7
    Search QuantiFast Probe-based Assays in human, mouse, rat NME7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NME7 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nme71 , 5 non-metastatic cells 7, protein expressed in (nucleoside-diphosphate more5
    NME/NM23 family member 71
    85.42(n)1
    88.53(a)1
      1 (71.63 cM)5
    1715671  NM_138314.31  NP_612187.21 
     1643128795 
    chicken
    (Gallus gallus)
    Aves NME71 NME/NM23 family member 7 76.53(n)
    78.67(a)
      100858145  XM_004938228.1  XP_004938285.1 
    lizard
    (Anolis carolinensis)
    Reptilia NME76
    NME/NM23 family member 7
    65(a)
    1 ↔ 1
    3(175559948-175648592)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC756772 hypothetical protein MGC75677 75.37(n)    BC061605.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ndpkz42 nucleoside diphosphate kinase-Z4 71.48(n)   30086  BC049398.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nmdyn-D71 , 3 nucleoside-diphosphate kinase3
    nmdyn-D71
    43(a)3
    48.94(n)1
    42.15(a)1
      3 85E43
    411741  NM_141669.31  NP_649926.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YNK16
    Nucleoside diphosphate kinase, catalyzes the trans...
    29(a)
    1 → many
    XI(314812-315273) YKL067W


    ENSEMBL Gene Tree for NME7 (if available)
    TreeFam Gene Tree for NME7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NME7 gene
    NME22  NME12  NME32  NME82  NME42  NME1-NME22  NME62  NME92  
    NME52  
    8 SIMAP similar genes for NME7 using alignment to 3 protein entries:     NDK7_HUMAN (see all proteins):
    NME5    NME6    c371H6.2    NME3    NME4    NME2
    NME1    NME2P1

    Find genes that share paralogs with NME7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NME7 (see all 4619)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs681510291,2
    C--140351470(-) GGCAC-/TGGCTGT
    GCCCGATATA
    TGTGG
    2 -- int11Minor allele frequency- TGGCTGTGCCCGATATA:0.00NA 2
    rs780182521,2
    C--140443011(+) ATATA-/TAACAAA 2 -- int10--------
    rs711217551,2
    C--140489239(-) GTTCT-/TAGCC 
            
    TGATT
    2 -- int11Minor allele frequency- TAGCC:0.00NA 2
    rs1491007401,2
    C--169102484(+) TAAAA-/AT/TC 
            
    AAGCT
    2 -- int10--------
    rs673003851,2
    C--169102486(+) AAAAA-/TCGCTTT 2 -- int10--------
    rs1378678141,2
    --169102591(+) GAAACA/GGAAAC 2 -- int10--------
    rs802697481,2
    C,F--169102601(+) CCTTTC/TGCAAA 2 -- int11Minor allele frequency- T:0.03WA 118
    rs37532931,2
    C,A--169102690(+) ACAGAC/TCTGGA 2 -- int18Minor allele frequency- T:0.47NA CSA WA EA 367
    rs1127503561,2
    C,F--169102705(+) ATGGCC/TGTTTT 2 -- int12Minor allele frequency- T:0.13WA 120
    rs758245301,2
    C--169102787(+) TCGTTC/TTGCTA 2 -- int10--------

    HapMap Linkage Disequilibrium report for NME7 (169101769 - 169337205 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NME7 (see all 39):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820717CNV Deletion20802225
    esv1001229CNV Deletion20482838
    esv2674167CNV Deletion23128226
    esv993090CNV Deletion20482838
    esv1106459CNV Deletion17803354
    esv2421693CNV Deletion20811451
    esv2719362CNV Deletion23290073
    esv2677260CNV Deletion23128226
    esv2719373CNV Deletion23290073
    dgv78e199CNV Deletion23128226

    Human Gene Mutation Database (HGMD): NME7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NME7
    DNA2.0 Custom Variant and Variant Library Synthesis for NME7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 613465    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for NME7:
    Primary ciliary dyskinesia

    Find genes that share disorders with NME7           About GenesLikeMe

    Genetic Association Database (GAD): NME7
    Human Genome Epidemiology (HuGE) Navigator: NME7 (4 documents)

    Export disorders for NME7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NME7 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with NME7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic predictors of fibrin D-dimer levels in healthy adults. (PubMed id 21502573)1, 4 Smith N.L....Hayward C. (Circulation 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    5. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (Hum. Mol. Genet. 2009)
    6. Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)1, 3 Desvignes T....Bobe J. (BMC Evol. Biol. 2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 29922 HGNC: 20461 AceView: NME7 Ensembl:ENSG00000143156 euGenes: HUgn29922
    ECgene: NME7 Kegg: 29922 H-InvDB: NME7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NME7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NME7 gene:
    Search GeneIP for patents involving NME7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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