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Aliases for NME7 Gene

Aliases for NME7 Gene

  • NME/NM23 Family Member 7 2 3 5
  • Non-Metastatic Cells 7, Protein Expressed In (Nucleoside-Diphosphate Kinase) 2 3
  • Cilia And Flagella Associated Protein 67 2 3
  • NDP Kinase 7 3 4
  • EC 4 58
  • Nm23-H7 3 4
  • NDK 7 3 4
  • Nucleoside Diphosphate Kinase 7 3
  • CFAP67 3
  • MN23H7 3
  • NDK7 3

External Ids for NME7 Gene

Previous GeneCards Identifiers for NME7 Gene

  • GC01P166788
  • GC01M164752
  • GC01M165797
  • GC01M166289
  • GC01M165833
  • GC01M167368
  • GC01M140347

Summaries for NME7 Gene

Entrez Gene Summary for NME7 Gene

  • This gene encodes a member of the non-metastatic expressed family of nucleoside diphosphate kinases. Members of this family are enzymes that catalyzes phosphate transfer from nucleoside triphosphates to nucleoside diphosphates. This protein contains two kinase domains, one of which is involved in autophosphorylation and the other may be inactive. This protein localizes to the centrosome and functions as a component of the gamma-tubulin ring complex which plays a role in microtubule organization. Mutations in this gene may be associated with venous thromboembolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

GeneCards Summary for NME7 Gene

NME7 (NME/NM23 Family Member 7) is a Protein Coding gene. Diseases associated with NME7 include Dextrocardia With Situs Inversus. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Pyrimidine metabolism (KEGG). GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME8.

UniProtKB/Swiss-Prot for NME7 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Additional gene information for NME7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME7 Gene

Genomics for NME7 Gene

Regulatory Elements for NME7 Gene

Enhancers for NME7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H169132 1.7 dbSUPER 33.6 +233.5 233509 4.7 CTCF ZNF362 NR2F1 HLF TRIM22 THRB RAD21 SSRP1 GATA2 POLR2A NME7 ATP1B1 LOC101928596 ENSG00000235575 PIR51723
GH01H169311 1.3 Ensembl ENCODE 36.4 +55.6 55599 1.1 PKNOX1 ATF1 ARNT ZNF2 TCF12 ZNF766 GATA2 ELK1 ATF7 FOS NME7 ENSG00000235575 BLZF1
GH01H169362 1.6 Ensembl ENCODE dbSUPER 29.1 +2.0 1979 7.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NME7 C1orf112 CCDC181 METTL18 BLZF1 ENSG00000235575
GH01H169308 1.2 Ensembl ENCODE 32.1 +58.6 58616 1.9 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 REST ZNF592 NME7 RN7SL333P METTL18 C1orf112 SCYL3 DPT ATP1B1 LOC101928596 ENSG00000235575 GC01P169296
GH01H169141 1.3 ENCODE dbSUPER 28.6 +221.1 221094 10 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 TCF12 REST MIER2 PPARG NME7 ATP1B1 LOC101928596 PIR51723
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NME7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NME7 Gene

Genomic Locations for NME7 Gene
235,970 bases
Minus strand

Genomic View for NME7 Gene

Genes around NME7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME7 Gene

Proteins for NME7 Gene

  • Protein details for NME7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleoside diphosphate kinase 7
    Protein Accession:
    Secondary Accessions:
    • A8K3T6
    • A8MY09
    • B3KSW9
    • Q5TGZ4

    Protein attributes for NME7 Gene

    376 amino acids
    Molecular mass:
    42492 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NME7 Gene


neXtProt entry for NME7 Gene

Selected DME Specific Peptides for NME7 Gene


Post-translational modifications for NME7 Gene

  • Ubiquitination at Lys51
  • Modification sites at PhosphoSitePlus

Other Protein References for NME7 Gene

Domains & Families for NME7 Gene

Gene Families for NME7 Gene

Suggested Antigen Peptide Sequences for NME7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NDK family.
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME7: view

Function for NME7 Gene

Molecular function for NME7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Enzyme Numbers (IUBMB) for NME7 Gene

Phenotypes From GWAS Catalog for NME7 Gene

Gene Ontology (GO) - Molecular Function for NME7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity TAS,IEA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NME7: view
genes like me logo Genes that share phenotypes with NME7: view

Animal Models for NME7 Gene

MGI Knock Outs for NME7:
  • Nme7 tm2b(EUCOMM)Hmgu

Animal Model Products

CRISPR Products

miRNA for NME7 Gene

miRTarBase miRNAs that target NME7

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NME7 Gene

Localization for NME7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NME7 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 3
nucleus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NME7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NME7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NME7 Gene

Pathways & Interactions for NME7 Gene

genes like me logo Genes that share pathways with NME7: view

Gene Ontology (GO) - Biological Process for NME7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0009117 nucleotide metabolic process IEA --
genes like me logo Genes that share ontologies with NME7: view

No data available for SIGNOR curated interactions for NME7 Gene

Drugs & Compounds for NME7 Gene

(11) Drugs for NME7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
dATP Experimental Pharma Full agonist, Agonist 0
dctp Experimental Pharma 0
dgtp Experimental Pharma 0

(12) Additional Compounds for NME7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxy-Inosine 5'-(tetrahydrogen triphosphate)
  • 2'-Deoxyinosine-5'-triphosphate
  • 2'-Ditp
  • Deoxyinosine 5'-triphosphate
  • Deoxyinosine triphosphate
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
genes like me logo Genes that share compounds with NME7: view

Transcripts for NME7 Gene

Unigene Clusters for NME7 Gene

NME/NM23 family member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME7 Gene

No ASD Table

Relevant External Links for NME7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NME7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NME7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NME7 Gene

This gene is overexpressed in Breast (27.4), Bone (8.1), Neutrophil (8.0), and Pancreatic juice (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NME7 Gene

NURSA nuclear receptor signaling pathways regulating expression of NME7 Gene:


SOURCE GeneReport for Unigene cluster for NME7 Gene:


Evidence on tissue expression from TISSUES for NME7 Gene

  • Nervous system(4.7)
  • Lung(4.5)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with NME7: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NME7 Gene

Orthologs for NME7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NME7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NME7 33 34
  • 99.73 (n)
(Canis familiaris)
Mammalia NME7 33 34
  • 92.38 (n)
(Bos Taurus)
Mammalia NME7 33 34
  • 91.49 (n)
(Mus musculus)
Mammalia Nme7 33 16 34
  • 85.42 (n)
(Rattus norvegicus)
Mammalia Nme7 33
  • 84.36 (n)
(Ornithorhynchus anatinus)
Mammalia NME7 34
  • 81 (a)
(Monodelphis domestica)
Mammalia NME7 34
  • 78 (a)
(Gallus gallus)
Aves NME7 33 34
  • 76.53 (n)
(Anolis carolinensis)
Reptilia NME7 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nme7 33
  • 68.79 (n)
MGC75677 33
(Danio rerio)
Actinopterygii nme7 33 34
  • 65.5 (n)
ndpkz4 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6857 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003227 33
  • 49.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta nmdyn-D7 35 33 34
  • 48.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 34
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.25 33
Species where no ortholog for NME7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NME7 Gene

Gene Tree for NME7 (if available)
Gene Tree for NME7 (if available)

Paralogs for NME7 Gene

Paralogs for NME7 Gene

(8) SIMAP similar genes for NME7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NME7: view

Variants for NME7 Gene

Sequence variations from dbSNP and Humsavar for NME7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000000494 -- 169,211,286(+) TTATA(C/G)GGGAA intron-variant
rs1000003176 -- 169,283,591(+) GTTGT(A/T)CCTTT intron-variant
rs1000005458 -- 169,316,195(+) TAAAT(A/G)AATAA intron-variant
rs1000010695 -- 169,305,094(+) TCCAA(C/T)ATGTC intron-variant
rs1000014498 -- 169,180,052(+) CAATT(C/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NME7 Gene

Variant ID Type Subtype PubMed ID
nsv958041 CNV deletion 24416366
nsv947448 CNV deletion 23825009
nsv831871 CNV loss 17160897
nsv831858 CNV gain 17160897
nsv825398 CNV gain 20364138
nsv825387 CNV gain 20364138
nsv825376 CNV loss 20364138
nsv820717 CNV deletion 20802225
nsv820118 CNV gain 19587683
nsv818567 CNV gain+loss 17921354
nsv548186 CNV loss 21841781
nsv548183 CNV gain+loss 21841781
nsv548164 CNV loss 21841781
nsv548157 CNV gain 21841781
nsv525520 CNV loss 19592680
nsv515530 CNV gain+loss 19592680
nsv514015 CNV loss 21397061
nsv511149 CNV loss 21212237
nsv508637 CNV deletion 20534489
nsv508044 OTHER sequence alteration 20534489
nsv477399 CNV novel sequence insertion 20440878
nsv442352 CNV loss 18776908
nsv159064 CNV insertion 16902084
nsv1161886 OTHER complex 26073780
nsv1124598 CNV duplication 24896259
nsv1122418 CNV deletion 24896259
nsv1078878 OTHER inversion 25765185
nsv1068314 CNV deletion 25765185
nsv1010010 CNV gain 25217958
nsv1004674 CNV gain 25217958
esv993090 CNV deletion 20482838
esv5790 CNV loss 19470904
esv4017 CNV loss 18987735
esv3890760 CNV loss 25118596
esv3587881 CNV loss 21293372
esv3587880 CNV loss 21293372
esv3587879 CNV loss 21293372
esv3575283 CNV gain 25503493
esv3575272 CNV gain 25503493
esv3542356 CNV deletion 23714750
esv33347 CNV loss 17666407
esv32640 CNV gain+loss 17666407
esv3008234 CNV deletion 24192839
esv2848902 CNV deletion 24192839
esv2764197 CNV loss 21179565
esv2761410 CNV loss 21179565
esv2719373 CNV deletion 23290073
esv2719362 CNV deletion 23290073
esv2719350 CNV deletion 23290073
esv2677260 CNV deletion 23128226
esv2677177 CNV deletion 23128226
esv2674167 CNV deletion 23128226
esv2421693 CNV deletion 20811451
esv22143 CNV gain+loss 19812545
esv1749280 CNV deletion 17803354
esv1584020 CNV insertion 17803354
esv1514014 CNV deletion 17803354
esv1106459 CNV deletion 17803354
esv1007713 CNV loss 20482838
esv1001229 CNV deletion 20482838
dgv78e199 CNV deletion 23128226
dgv630n54 CNV loss 21841781
dgv629n54 CNV loss 21841781
dgv628n54 CNV gain 21841781
dgv627n54 CNV gain 21841781
dgv626n54 CNV gain+loss 21841781
dgv625n54 CNV loss 21841781
dgv459n100 CNV gain 25217958
dgv42n27 CNV loss 19166990
dgv115e212 CNV gain 25503493
dgv114e212 CNV gain 25503493
dgv113e212 CNV loss 25503493
dgv112e212 CNV loss 25503493

Variation tolerance for NME7 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NME7 Gene

Disorders for NME7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NME7 Gene - From: Orphanet

Disorder Aliases PubMed IDs
dextrocardia with situs inversus
  • situs inversus totalis
- elite association - COSMIC cancer census association via MalaCards
Search NME7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NME7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NME7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NME7 Gene

Publications for NME7 Gene

  1. Genetic predictors of fibrin D-dimer levels in healthy adults. (PMID: 21502573) Smith NL … Hayward C (Circulation 2011) 3 45 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 45 60
  4. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 45 60
  5. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung CL … Kung AW (Human molecular genetics 2009) 3 45 60

Products for NME7 Gene

  • Addgene plasmids for NME7

Sources for NME7 Gene

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