Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NME7 Gene

Aliases for NME7 Gene

  • NME/NM23 Family Member 7 2 3
  • Non-Metastatic Cells 7, Protein Expressed In (Nucleoside-Diphosphate Kinase) 2 3
  • Cilia And Flagella Associated Protein 67 2 3
  • NDP Kinase 7 3 4
  • EC 4 63
  • Nm23-H7 3 4
  • MN23H7 3 6
  • NDK 7 3 4
  • Nucleoside Diphosphate Kinase 7 3
  • Nucleoside-Diphosphate Kinase 7 3
  • CFAP67 3
  • NDK7 3

External Ids for NME7 Gene

Previous GeneCards Identifiers for NME7 Gene

  • GC01P166788
  • GC01M164752
  • GC01M165797
  • GC01M166289
  • GC01M165833
  • GC01M167368
  • GC01M140347

Summaries for NME7 Gene

GeneCards Summary for NME7 Gene

NME7 (NME/NM23 Family Member 7) is a Protein Coding gene. Among its related pathways are Metabolism and purine nucleotide salvage. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME5.

UniProtKB/Swiss-Prot for NME7 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME7 Gene

Genomics for NME7 Gene

Regulatory Elements for NME7 Gene

Genomic Location for NME7 Gene

169,132,020 bp from pter
169,367,967 bp from pter
235,948 bases
Minus strand

Genomic View for NME7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NME7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME7 Gene

Proteins for NME7 Gene

  • Protein details for NME7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleoside diphosphate kinase 7
    Protein Accession:
    Secondary Accessions:
    • A8K3T6
    • A8MY09
    • B3KSW9
    • Q5TGZ4

    Protein attributes for NME7 Gene

    376 amino acids
    Molecular mass:
    42492 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NME7 Gene


neXtProt entry for NME7 Gene

Proteomics data for NME7 Gene at MOPED

Selected DME Specific Peptides for NME7 Gene

Post-translational modifications for NME7 Gene

  • Ubiquitination at Lys51
  • Modification sites at PhosphoSitePlus

Other Protein References for NME7 Gene

Antibody Products

Domains for NME7 Gene

Gene Families for NME7 Gene

Suggested Antigen Peptide Sequences for NME7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DM10 domain.
  • Belongs to the NDK family.
  • Contains 1 DM10 domain.
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME7: view

Function for NME7 Gene

Molecular function for NME7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

Enzyme Numbers (IUBMB) for NME7 Gene

Gene Ontology (GO) - Molecular Function for NME7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NME7: view
genes like me logo Genes that share phenotypes with NME7: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NME7 Gene

Localization for NME7 Gene

Subcellular locations from

Jensen Localization Image for NME7 Gene COMPARTMENTS Subcellular localization image for NME7 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NME7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0036064 ciliary basal body IEA --
genes like me logo Genes that share ontologies with NME7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NME7 Gene

Pathways for NME7 Gene

genes like me logo Genes that share pathways with NME7: view

Gene Ontology (GO) - Biological Process for NME7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement IEA --
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
genes like me logo Genes that share ontologies with NME7: view

Drugs for NME7 Gene

(23) HMDB Compounds for NME7 Gene

Compound Synonyms Cas Number PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxy-Inosine 5'-(tetrahydrogen triphosphate)
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
  • CDP
Cytidine triphosphate
  • 5'-(Tetrahydrogen triphosphate) cytidine
genes like me logo Genes that share compounds with NME7: view

Transcripts for NME7 Gene

Unigene Clusters for NME7 Gene

NME/NM23 family member 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NME7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME7 Gene

No ASD Table

Relevant External Links for NME7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NME7 Gene

mRNA expression in normal human tissues for NME7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NME7 Gene

This gene is overexpressed in Breast (27.4), Bone (8.1), Neutrophil (8.0), and Pancreatic juice (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NME7 Gene

SOURCE GeneReport for Unigene cluster for NME7 Gene Hs.706952

genes like me logo Genes that share expressions with NME7: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for NME7 Gene

Orthologs for NME7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NME7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NME7 35
  • 91.49 (n)
  • 92.55 (a)
NME7 36
  • 92 (a)
(Canis familiaris)
Mammalia NME7 35
  • 92.38 (n)
  • 94.15 (a)
NME7 36
  • 94 (a)
(Mus musculus)
Mammalia Nme7 35
  • 85.42 (n)
  • 88.53 (a)
Nme7 16
Nme7 36
  • 82 (a)
(Pan troglodytes)
Mammalia NME7 35
  • 99.73 (n)
  • 99.73 (a)
NME7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nme7 35
  • 84.36 (n)
  • 87.2 (a)
(Monodelphis domestica)
Mammalia NME7 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia NME7 36
  • 81 (a)
(Gallus gallus)
Aves NME7 35
  • 76.53 (n)
  • 78.67 (a)
NME7 36
  • 78 (a)
(Anolis carolinensis)
Reptilia NME7 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75677 35
nme7 35
  • 68.79 (n)
  • 67.55 (a)
(Danio rerio)
Actinopterygii ndpkz4 35
nme7 35
  • 65.5 (n)
  • 64.96 (a)
nme7 36
  • 66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6857 35
fruit fly
(Drosophila melanogaster)
Insecta nmdyn-D7 37
  • 43 (a)
nmdyn-D7 35
  • 48.94 (n)
  • 42.15 (a)
nmdyn-D7 36
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003227 35
  • 49.58 (n)
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 36
  • 29 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.25 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for NME7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NME7 Gene

Gene Tree for NME7 (if available)
Gene Tree for NME7 (if available)

Paralogs for NME7 Gene

Paralogs for NME7 Gene

(8) SIMAP similar genes for NME7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NME7: view

Variants for NME7 Gene

Sequence variations from dbSNP and Humsavar for NME7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs718031 -- 169,223,849(+) TATCT(A/T)TTATT intron-variant
rs718032 -- 169,223,790(+) ATAGA(G/T)AGAGA intron-variant
rs724048 -- 169,260,617(-) TACCA(C/T)GCTGT intron-variant
rs724049 -- 169,260,530(-) TTCAG(A/G)ACACA intron-variant
rs745921 -- 169,151,209(-) CAGCA(C/T)CAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NME7 Gene

Variant ID Type Subtype PubMed ID
nsv831858 CNV Gain 17160897
esv22143 CNV Gain+Loss 19812545
esv2677177 CNV Deletion 23128226
esv2677260 CNV Deletion 23128226
esv4017 CNV Deletion 18987735
esv2719350 CNV Deletion 23290073
esv1001229 CNV Deletion 20482838
esv1106459 CNV Deletion 17803354
esv5790 CNV Loss 19470904
nsv525520 CNV Loss 19592680
nsv872531 CNV Loss 21882294
nsv508044 CNV Loss 20534489
esv2719362 CNV Deletion 23290073
esv1007713 CNV Loss 20482838
nsv508637 CNV Loss 20534489
nsv820717 CNV Deletion 20802225
nsv825376 CNV Loss 20364138
esv993090 CNV Deletion 20482838
nsv820118 CNV Gain 19587683
dgv78e199 CNV Deletion 23128226
esv2421693 CNV Deletion 20811451
nsv511149 CNV Loss 21212237
nsv825387 CNV Gain 20364138
nsv825398 CNV Gain 20364138
esv32640 CNV Gain+Loss 17666407
nsv514015 CNV Loss 21397061
dgv42n27 CNV Loss 19166990
nsv515530 CNV Gain+Loss 19592680
nsv818567 CNV Gain+Loss 17921354
nsv442352 CNV CNV 18776908
nsv872532 CNV Loss 21882294
esv1514014 CNV Deletion 17803354
esv2719373 CNV Deletion 23290073
esv33347 CNV Loss 17666407
esv2674167 CNV Deletion 23128226
nsv831871 CNV Loss 17160897
esv1749280 CNV Deletion 17803354
esv1584020 CNV Insertion 17803354
nsv159064 CNV Insertion 16902084

Relevant External Links for NME7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NME7 Gene

Disorders for NME7 Gene

(1) University of Copenhagen DISEASES for NME7 Gene

Relevant External Links for NME7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NME7: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for NME7 Gene

Publications for NME7 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3 48
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  4. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 48
  5. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T. … Bobe J. (BMC Evol. Biol. 2009) 2 3

Products for NME7 Gene

  • Addgene plasmids for NME7

Sources for NME7 Gene

Back to Top