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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NME6 Gene

protein-coding GIFtS: 56
GCID: GC03M048334

NME/NM23 nucleoside diphosphate kinase 6

(Previous names: non-metastatic cells 6, protein expressed in (nucleoside-diphosphate...)

Explore 3 diseases affiliated with
NME6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NME/NM23 Nucleoside Diphosphate Kinase 6¹ ²		NDP Kinase 6² ³
IPIA-ALPHA¹ ²		EC 2.7.4.6³ ⁸
NM23-H6¹ ²		Nucleoside Diphosphate Kinase 6²
Non-Metastatic Cells 6, Protein Expressed In (Nucleoside-Diphosphate Kinase)¹ ²		IPIA-Alpha¹
Inhibitor Of P53-Induced Apoptosis-Alpha² ³		Nm23-H6¹
NDK 6² ³

External Ids:	HGNC: 20567¹	Entrez Gene: 10201²	Ensembl: ENSG00000172113⁷	OMIM: 608294⁵	UniProtKB: O75414³

Export aliases for NME6 gene to outside databases

Previous GC identifers: GC03M047618 GC03M048154 GC03M048296 GC03M048311

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NME6:

Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of

gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates

(Mehus et al., 1999 (PubMed 10453732)).(supplied by OMIM, Jul 2010)

UniProtKB/Swiss-Prot: NDK6_HUMAN, O75414

Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is

transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Inhibitor of p53-induced apoptosis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NME6 gene promoter:
RFX1 AML1a SREBP-1c FOXD1 HNF-3beta SREBP-1b HEN1 SREBP-1a FOXO4 SEF-1 (1)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NME6 promoter sequence

Search SABiosciences Chromatin IP Primers for NME6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NME6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31

NME6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME6 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M048334: view genomic region (about GC identifiers)

Start:	48,334,754 bp from pter	End:	48,343,175 bp from pter
Size:	8,422 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NDK6_HUMAN, O75414 (See protein sequence)

Recommended Name: Nucleoside diphosphate kinase 6

Size: 186 amino acids; 21142 Da

Cofactor: Magnesium (By similarity)

Sequence caution: Sequence=AAC69439.1; Type=Erroneous initiation; Sequence=AAH01808.1; Type=Erroneous initiation;

Sequence=AAH12828.1; Type=Erroneous initiation; Sequence=BAD96275.1; Type=Erroneous initiation;

Secondary accessions: B4DGW7 B4DM99 Q53HM5 Q96E73 Q9BQ63

Alternative splicing: 3 isoforms: O75414-1 O75414-2 O75414-3

Explore the universe of human proteins at neXtProt for NME6: NX_O75414

4 DME Specific Peptides for NME6 (O75414)

IKPDAVA

AHPLILEA

GRFFYQRLVEFM

GLTDTRNTTHGSDS

NME6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005784.1

ENSEMBL proteins:

ENSP00000416658 ENSP00000392352 ENSP00000394232 ENSP00000399582 ENSP00000406642

ENSP00000414842 ENSP00000394128 ENSP00000407933 ENSP00000393261 ENSP00000411116

ENSP00000392715 ENSP00000410435 ENSP00000405755 ENSP00000440286 ENSP00000391499

ENSP00000398070

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NME6 OriGene Protein Over-expression Lysate: NME6 OriGene Custom Protein Services for NME6
	GenScript Custom Purified and Recombinant Proteins Services for NME6
	Novus Biologicals NME6 Protein Novus Biologicals NME6 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NME6

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	10618642

NME6 for ontologies About GeneDecksing

NME6 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals NME6 Antibodies
	Search for Antibodies for NME6 at Abcam
	Uscn Antibodies for NME6
	ThermoFisher Antibodies for NME6

Assay Products for NME6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NME6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NME6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NME6 for domains About GeneDecksing

2 InterPro domains/families:

IPR023005 Nucleoside_diP_kinase_AS

IPR001564 Nucleoside_diP_kinase

Graphical View of Domain Structure for InterPro Entry O75414

ProtoNet protein and cluster: O75414

1 Blocks protein family: IPB001564 Nucleoside diphosphate kinase

UniProtKB/Swiss-Prot: NDK6_HUMAN, O75414

Similarity: Belongs to the NDK family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NDK6_HUMAN, O75414

Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is

transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Inhibitor of p53-induced apoptosis

Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

Genatlas biochemistry entry for NME6:

non-metastatic cells 6,protein,with a nm23 nucleoside diphosphate kinase gene family,predominantly expressed in

kidney,prostate,ovary,intestine

Enzyme Number (IUBMB): EC 2.7.4.6¹ ²

miRNA Products:		OriGene 3'-UTR Clone: NME6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NME6
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate NME6 (see all 17):
		hsa-let-7d hsa-let-7c hsa-miR-520a-5p hsa-miR-583 hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-3935

		SwitchGear 3'UTR luciferase reporter plasmid: NME6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NME6 (see all 4) OriGene shRNA RFP: NME6 OriGene siRNA: NME6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NME6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NME6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NME6 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NME6 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NME6 (NM_005793)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NME6
		Search LifeMap BioReagents cell lines for NME6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME6

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004550	nucleoside diphosphate kinase activity	IDA	10618642
GO:0005524	ATP binding	NAS	--
GO:0046872	metal ion binding	IEA	--

NME6 for ontologies About GeneDecksing

Animal Models:
1 MGI phenotypic allele

for Nme6 (no phenotypes)

NME6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

pyrimidine ribonucleotides interconversion

	pyrimidine ribonucleotides interconversion	1.00			pyrimidine deoxyribonucleotides de novo biosynthesis I	0.50
	pyrimidine ribonucleotides de novo biosynthesis	0.88			salvage pathways of pyrimidine ribonucleotides	0.45

Purine metabolism

Purine metabolism

1.00

Pyrimidine metabolism

0.38

ATP/ITP metabolism

ATP/ITP metabolism

1.00

ATP/ITP metabolism

0.98

Metabolism

Metabolic pathways

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NME6

ATP/ITP metabolism

1 GeneGo (Thomson Reuters) Pathway for NME6

ATP/ITP metabolism

4 BioSystems Pathways for NME6

	pyrimidine ribonucleotides de novo biosynthesis
	pyrimidine ribonucleotides interconversion
	pyrimidine deoxyribonucleotides de novo biosynthesis I
	salvage pathways of pyrimidine ribonucleotides

3 Kegg Pathways (Kegg details for NME6):

	Purine metabolism
	Pyrimidine metabolism
	Metabolic pathways

NME6 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NME6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/93 Interacting proteins for NME6 (ENSP00000416658⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 93)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AK2	ENSP00000346921⁴	STRING: ENSP00000346921
CMPK1	ENSP00000360939⁴	STRING: ENSP00000360939
CTPS1	ENSP00000361699⁴	STRING: ENSP00000361699
CTPS2	ENSP00000352222⁴	STRING: ENSP00000352222
DTYMK	ENSP00000304802⁴	STRING: ENSP00000304802

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006165	nucleoside diphosphate phosphorylation	--	--
GO:0006183	GTP biosynthetic process	IEA	--
GO:0006228	UTP biosynthetic process	IEA	--
GO:0006241	CTP biosynthetic process	IEA	--
GO:0006915	apoptotic process	IEA	--

NME6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NME6

10/23 HMDB Compounds for NME6 (see all 23) About this table

Compound	Synonyms	CAS #	PubMed Ids
2'-Deoxyinosine triphosphate	2'-Deoxyinosine-5'-triphosphate (see all 6)	16595-02-1	--
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
CDP	CDP (see all 3)	63-38-7	--
Cytidine triphosphate	cytidine 5'-(tetrahydrogen triphosphate) (see all 15)	65-47-4	--
Deoxyuridine triphosphate	2'-Deoxyuridine-5'-triphosphorate (see all 9)	1173-82-6	--
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
IDP	5'-IDP (see all 10)	86-04-4	--
Inosine triphosphate	inosine 5'-(tetrahydrogen triphosphate) (see all 13)	132-06-9	--

Search CenterWatch for drugs/clinical trials and news about NME6 / NDK6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NME6 gene:

NM_005793.3

Unigene Cluster for NME6:

NME/NM23 nucleoside diphosphate kinase 6

Hs.465558 [show with all ESTs]

Unigene Representative Sequence: BQ071537

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000421967(uc003cso.3 uc011bbh.2 uc010hju.3 uc003csp.4 uc011bbi.2)

ENST00000452211 ENST00000444069 ENST00000415644 ENST00000415053 ENST00000442597

ENST00000447314 ENST00000418431 ENST00000451657 ENST00000435684 ENST00000425930

ENST00000456495 ENST00000454531 ENST00000494209 ENST00000447724 ENST00000484959

ENST00000302378 ENST00000495734

miRNA Products:		OriGene 3'-UTR Clone: NME6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NME6
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate NME6 (see all 17):
		hsa-let-7d hsa-let-7c hsa-miR-520a-5p hsa-miR-583 hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-3935

		SwitchGear 3'UTR luciferase reporter plasmid: NME6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NME6 (see all 4) OriGene shRNA RFP: NME6 OriGene siRNA: NME6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NME6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NME6 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NME6 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NME6 (NM_005793)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NME6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NME6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NME6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NME6

Additional cDNA sequence:

AF051941.1 AK222555.1 AK294809.1 AK297364.1 AK308970.1 AK309090.1 AK311152.1 BC001808.2

BC012828.2 U90449.1

15 DOTS entries:

DT.205708 DT.95163055 DT.100783655 DT.91753114 DT.91753116 DT.100783654 DT.100024962 DT.120844067

DT.120844135 DT.91753112 DT.91753119 DT.97841744 DT.120844073 DT.120844126 DT.97819332

24/82 AceView cDNA sequences (see all 82):

BU153358 BG166172 BC012828 NM_005793 BU180342 BQ219851 BC001808 CA848190

BE788532 BU196757 BE270791 BM832626 CA848473 BQ233211 BG284082 CB151307

BE270352 BU193815 BU678095 BX402767 BE560178 BU176024 BE866839 BG429466

GeneLoc Exon Structure

5/19 Alternative Splicing Database (ASD) splice patterns (SP) for NME6 (see all 19) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7	^	8a	·
SP1:													-		-		-		-		-		-		-		-		-				-		-						-		-				-
SP2:													-		-		-		-		-		-		-		-		-				-		-												-
SP3:																			-		-		-		-		-		-				-		-						-		-				-
SP4:																					-		-		-		-		-				-		-						-						-
SP5:																					-		-		-		-		-				-		-						-		-				-

ExUns:	8b	·	8c	·	8d	·	8e	·	8f	·	8g	·	8h	·	8i
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for NME6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NME6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGACTCTGT

About this image
See NME6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NME6

SOURCE GeneReport for Unigene cluster: Hs.465558

UniProtKB/Swiss-Prot: NDK6_HUMAN, O75414

Tissue specificity: Expressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary,

intestine, and spleen

SABiosciences Custom PCR Arrays for NME6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NME6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NME6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NME6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NME6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for NME6 gene from 9/34 species (see all 34) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NME6¹	non-metastatic cells 6, protein expressed in (nucleoside-diphosphate more	69.3(n) 69.49(a)		426866 XM_424474.3 XP_424474.1
lizard (Anolis carolinensis)	Reptilia	NME6⁶ -- (see all 3)	--	65(a) 32(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	GL343765.1(46424-53449) 6(47767459-47772252)
African clawed frog (Xenopus laevis)	Amphibia	Xl.4467²	Xenopus laevis transcribed sequence with weak similarity more	72.44(n)		BX845338.1
zebrafish (Danio rerio)	Actinopterygii	ndpkz6²	nucleoside diphosphate kinase-Z6	72.3(n)		58120 AF241153.1
fruit fly (Drosophila melanogaster)	Insecta	nmdyn-D6¹	CG5310-PA	51.82(n) 47.45(a)		32396 NM_132737.2 NP_572965.1
worm (Caenorhabditis elegans)	Secernentea	ndk-1⁶	Nucleoside diphosphate kinase	29(a)	possible ortholog	I(10553101-10553902)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G23895⁶ NDPK1⁶ (see all 5)	nucleoside diphosphate kinase 1 (see all 5)	9(a) 25(a) (see all 5)	possible ortholog possible ortholog (see all 5)	4(12422087-12426475) 4(5923400-5924532)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	nucleoside diphosphate kinase, putative, expressed... nucleoside diphosphate kinase, putative, expressed... (see all 4)	28(a) 21(a) (see all 4)	possible ortholog possible ortholog (see all 4)	7(18333879-18336494) 10(22186387-22188912)
E. coli (Escherichia coli)	Gamma proteobacteria	ndk⁶	multifunctional nucleoside diphosphate kinase and ...	38(a)	1 → many	Chromosome(2642455-2642886)

ENSEMBL Gene Tree for NME6 (if available)
TreeFam Gene Tree for NME6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NME6 gene

NME1² NME2² NME3² NME8² NME4² NME7² NME1-NME2² NME9²

NME5²

8 SIMAP similar genes for NME6 using alignment to 6 protein entries: NDK6_HUMAN (see all proteins):

NME5 NME7 NME4 c371H6.2 NME2 NME3

NME2P1 NME1

NME6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139261181^1,2		--	48335189(+)	`TGCCAC/TGTTAT`	1	--	int¹		0	--	--	--	--
rs143699254^1,2		--	48335240(+)	`ACCCAA/GTCATG`	1	--	int¹		0	--	--	--	--
rs146808113^1,2		--	48335290(+)	`AGAATG/TTATGA`	1	--	int¹		0	--	--	--	--
rs190462557^1,2		--	48335433(+)	`GAGAAG/TTCAGA`	1	--	int¹		0	--	--	--	--
rs71074229^1,2	C	--	48335576(-)	`AAAAAA/-AAAAA`	1	--	ut3¹		1		NA	2
rs1134867^1,2	C,F,H,	--	48335808(-)	`GAGGCG/AGGCGG`	1	--	ut3¹		8		NA MN CSA	198
rs3197223^1,2	C,F,H,	--	48335857(-)	`AGGCCG/AGGCAC`	1	--	ut3¹ ese³		22		NS EA NA MN CSA WA	2526
rs181840018^1,2		--	48336048(+)	`AGGCTG/TCCCTG`	1	--	ut3¹		0	--	--	--	--
rs186108639^1,2		--	48336063(+)	`TAGGAC/GAATGT`	1	--	ut3¹		0	--	--	--	--
rs188911902^1,2	C,	--	48336117(+)	`CTTCAC/TAGACC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NME6 (48334754 - 48343175 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NME6: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NME6 for disorders           About GeneDecksing

OMIM gene information: 608294    OMIM disorders: --

3 diseases for NME6:    About MalaCards

prostate cancer pneumonia prostatitis

Human Genome Epidemiology (HuGE) Navigator: NME6 (1 document)

Export disorders for NME6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NME6 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with NME6)

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NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. (PubMed id 10453732)^{1, 2, 3, 9} Mehus J.G.... Lambeth D.O. (1999)
Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)^{1, 3} Desvignes T....Bobe J. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6, localizes in mitochondria and affects cytokinesis. (PubMed id 10618642)¹ Tsuiki H....Nakamura H. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10201	HGNC: 20567	AceView: NME6	Ensembl:ENSG00000172113	euGenes: HUgn10201
ECgene: NME6	Kegg: 10201	H-InvDB: NME6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NME6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NME6	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NME6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NME6 gene:
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GeneCards and IP:
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NME/NM23 nucleoside diphosphate kinase 6

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NME/NM23 nucleoside diphosphate kinase 6

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