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NME6 Gene

protein-coding   GIFtS: 60
GCID: GC03M048334

NME/NM23 Nucleoside Diphosphate Kinase 6

(Previous names: non-metastatic cells 6, protein expressed in (nucleoside-diphosphate...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NME/NM23 Nucleoside Diphosphate Kinase 61 2     IPIA-ALPHA2
Non-Metastatic Cells 6, Protein Expressed In (Nucleoside-Diphosphate
Kinase)1 2
     NM23-H62
Inhibitor Of P53-Induced Apoptosis-Alpha2 3     Nucleoside Diphosphate Kinase 62
NDK 62 3     IPIA-alpha3
NDP Kinase 62 3     nm23-H63
EC 2.7.4.63 8     

External Ids:    HGNC: 205671   Entrez Gene: 102012   Ensembl: ENSG000001721137   OMIM: 6082945   UniProtKB: O754143   

Export aliases for NME6 gene to outside databases

Previous GC identifers: GC03M047618 GC03M048154 GC03M048296 GC03M048311


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NME6 Gene:
Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of
gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and
diphosphates (Mehus et al., 1999 (PubMed 10453732)).(supplied by OMIM, Jul 2010)

GeneCards Summary for NME6 Gene:
NME6 (NME/NM23 nucleoside diphosphate kinase 6) is a protein-coding gene. Diseases associated with NME6 include pneumonia, and malaria. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME2.

UniProtKB/Swiss-Prot: NDK6_HUMAN, O75414
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is
transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Inhibitor of p53-induced apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NME6 gene promoter:
         RFX1   AML1a   SREBP-1c   FOXD1   HNF-3beta   SREBP-1b   HEN1   SREBP-1a   FOXO4   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNME6 promoter sequence
   Search Chromatin IP Primers for NME6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

NME6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048334:  view genomic region     (about GC identifiers)

Start:
48,334,754 bp from pter      End:
48,343,175 bp from pter
Size:
8,422 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NDK6_HUMAN, O75414 (See protein sequence)
Recommended Name: Nucleoside diphosphate kinase 6  
Size: 186 amino acids; 21142 Da
Cofactor: Magnesium (By similarity)
Sequence caution: Sequence=AAC69439.1; Type=Erroneous initiation; Sequence=AAH01808.1; Type=Erroneous initiation;
Sequence=AAH12828.1; Type=Erroneous initiation; Sequence=BAD96275.1; Type=Erroneous initiation;
Secondary accessions: B4DGW7 B4DM99 Q53HM5 Q96E73 Q9BQ63
Alternative splicing: 3 isoforms:  O75414-1   O75414-2   O75414-3   

Explore the universe of human proteins at neXtProt for NME6: NX_O75414

Explore proteomics data for NME6 at MOPED

4 DME Specific Peptides for NME6 (O75414)
 IKPDAVA  AHPLILEA  GRFFYQRLVEFM  GLTDTRNTTHGSDS 


See NME6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005784.1  
ENSEMBL proteins: 
 ENSP00000416658   ENSP00000392352   ENSP00000394232   ENSP00000399582   ENSP00000406642  
 ENSP00000414842   ENSP00000394128   ENSP00000407933   ENSP00000393261   ENSP00000411116  
 ENSP00000392715   ENSP00000410435   ENSP00000405755   ENSP00000440286   ENSP00000391499  
 ENSP00000398070  

NME6 Human Recombinant Protein Products:

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Novus Biologicals NME6 Protein
Novus Biologicals NME6 Lysates
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Cloud-Clone Corp. Proteins for NME6

NME6 Antibody Products:

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NME6 Assay Products:

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GenScript Custom Assay Services for NME6
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Cloud-Clone Corp. ELISAs for NME6
Cloud-Clone Corp. CLIAs for NME6


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR023005 Nucleoside_diP_kinase_AS
 IPR001564 Nucleoside_diP_kinase

Graphical View of Domain Structure for InterPro Entry O75414

ProtoNet protein and cluster: O75414

1 Blocks protein domain: IPB001564 Nucleoside diphosphate kinase

UniProtKB/Swiss-Prot: NDK6_HUMAN, O75414
Similarity: Belongs to the NDK family


NME6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NDK6_HUMAN, O75414
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is
transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Inhibitor of p53-induced apoptosis
Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

     Genatlas biochemistry entry for NME6:
non-metastatic cells 6,protein,with a nm23 nucleoside diphosphate kinase gene family,predominantly expressed in
kidney,prostate,ovary,intestine

     Enzyme Number (IUBMB): EC 2.7.4.61 2

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004550nucleoside diphosphate kinase activity IDA10618642
GO:0005524ATP binding IEA--
GO:0046872metal ion binding IEA--
     
NME6 for ontologies           About GeneDecksing


Phenotypes:
     1 MGI phenotypic allele for Nme6 (no phenotypes)

NME6 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NME6
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NME6

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NME6
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NME6

miRNA
Products:
    
miRTarBase miRNAs that target NME6:
hsa-mir-98-5p (MIRT027772), hsa-let-7b-5p (MIRT032439)

Block miRNA regulation of human, mouse, rat NME6 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate NME6 (see all 17):
hsa-let-7d hsa-let-7c hsa-miR-520a-5p hsa-miR-583 hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-3935
SwitchGear 3'UTR luciferase reporter plasmidNME6 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for NME6
Predesigned siRNA for gene silencing in human, mouse, rat NME6

Gene Editing
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Clone
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OriGene clones in human, mouse for NME6 (see all 6)
OriGene ORF clones in mouse, rat for NME6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NME6 (NM_005793)
Sino Biological Human cDNA Clone for NME6
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME6

Cell Line
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GenScript Custom overexpressing Cell Line Services for NME6
Browse ESI BIO Cell Lines and PureStem Progenitors for NME6 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME6


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol2
nucleus2
peroxisome2
extracellular1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA10618642

NME6 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NME6 About    
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Purine metabolism (KEGG)
Purine metabolism0.38
ATP ITP metabolism0.31
Pyrimidine metabolism0.38
purine deoxyribonucleosides salvage0.00
2superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
adenosine deoxyribonucleotides de novo biosynthesis0.00
guanosine deoxyribonucleotides de novo biosynthesis0.52
pyrimidine deoxyribonucleotides de novo biosynthesis0.00
superpathway of pyrimidine deoxyribonucleoside salvage0.46
UTP and CTP de novo biosynthesis0.00
CMP phosphorylation0.00
superpathway of pyrimidine ribonucleotides de novo biosynthesis0.00
3purine nucleotide salvage
purine nucleotide salvage0.78
guanosine nucleotides de novo biosynthesis0.00
purine nucleotides de novo biosynthesis0.78
guanosine ribonucleotides de novo biosynthesis0.00
4Metabolism
Metabolic pathways0.38

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for NME6
    ATP/ITP metabolism

Selected BioSystems Pathways for NME6 (see all 15)
    purine nucleotides de novo biosynthesis
superpathway of pyrimidine ribonucleotides de novo biosynthesis
purine deoxyribonucleosides salvage
guanosine nucleotides de novo biosynthesis
purine nucleotide salvage



3 Kegg Pathways  (Kegg details for NME6):
    Purine metabolism
Pyrimidine metabolism
Metabolic pathways


NME6 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NME6
Interactions:

    Search GeneGlobe Interaction Network for NME6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NME6 (ENSP000004166584) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
InteractantInteraction Details
GeneCardExternal ID(s)
CMPK1ENSP000003609394STRING: ENSP00000360939
CTPS1ENSP000003616994STRING: ENSP00000361699
CTPS2ENSP000003522224STRING: ENSP00000352222
DTYMKENSP000003048024STRING: ENSP00000304802
DUTENSP000003703764STRING: ENSP00000370376
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Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006165nucleoside diphosphate phosphorylation ----
GO:0006183GTP biosynthetic process IEA--
GO:0006228UTP biosynthetic process IEA--
GO:0006241CTP biosynthetic process IEA--
GO:0006915apoptotic process IEA--

NME6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NME6 (NDK6)

Selected HMDB Compounds for NME6 (see all 23)    About this table
CompoundSynonyms CAS #PubMed Ids
2'-Deoxyinosine triphosphate2'-Deoxyinosine-5'-triphosphate (see all 6)16595-02-1--
ADPadenosindiphosphorsaeure (see all 8)58-64-0--
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
CDPCDP (see all 3)63-38-7--
Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
Guanosine diphosphate5'-GDP (see all 10)146-91-8--
Guanosine triphosphate5'-GTP (see all 10)86-01-1--
IDP5'-IDP (see all 10)86-04-4--
Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NME6 gene: 
NM_005793.3  

Unigene Cluster for NME6:

NME/NM23 nucleoside diphosphate kinase 6
Hs.465558  [show with all ESTs]
Unigene Representative Sequence: BQ071537
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
ENST00000421967(uc003cso.3 uc011bbh.2 uc010hju.3 uc003csp.4 uc011bbi.2)
ENST00000452211 ENST00000444069 ENST00000415644 ENST00000415053 ENST00000442597
ENST00000447314 ENST00000418431 ENST00000451657 ENST00000435684 ENST00000425930
ENST00000456495 ENST00000454531 ENST00000494209 ENST00000447724 ENST00000484959
ENST00000302378 ENST00000495734
Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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Block miRNA regulation of human, mouse, rat NME6 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate NME6 (see all 17):
hsa-let-7d hsa-let-7c hsa-miR-520a-5p hsa-miR-583 hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-3935
SwitchGear 3'UTR luciferase reporter plasmidNME6 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for NME6
Predesigned siRNA for gene silencing in human, mouse, rat NME6
Clone
Products:
     
OriGene clones in human, mouse for NME6 (see all 6)
OriGene ORF clones in mouse, rat for NME6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NME6 (NM_005793)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME6
Primer
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OriGene qPCR primer pairs and template standards for NME6
OriGene qSTAR qPCR primer pairs in human, mouse for NME6
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NME6
  QuantiTect SYBR Green Assays in human, mouse, rat NME6
  QuantiFast Probe-based Assays in human, mouse, rat NME6

Additional mRNA sequence: 

AF051941.1 AK222555.1 AK294809.1 AK297364.1 AK308970.1 AK309090.1 AK311152.1 BC001808.2 
BC012828.2 U90449.1 

15 DOTS entries:

DT.205708  DT.95163055  DT.100783655  DT.91753114  DT.91753116  DT.100783654  DT.100024962  DT.120844067 
DT.120844135  DT.91753112  DT.91753119  DT.97841744  DT.120844073  DT.120844126  DT.97819332 

Selected AceView cDNA sequences (see all 82):

BU180342 BG284082 BQ219851 BU196757 BG166172 BM832626 BU153358 CA848473 
CA848190 BE270352 BE270791 BC012828 BQ233211 CB151307 NM_005793 BC001808 
BU193815 BE788532 CB148942 U90449 BX470901 BX361514 BX355461 AA627921 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for NME6 (see all 19)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a ·
SP1:                                      -     -     -     -     -     -     -     -     -           -     -                 -     -           -               
SP2:                                      -     -     -     -     -     -     -     -     -           -     -                                   -               
SP3:                                                        -     -     -     -     -     -           -     -                 -     -           -               
SP4:                                                              -     -     -     -     -           -     -                 -                 -               
SP5:                                                              -     -     -     -     -           -     -                 -     -           -               

ExUns: 8b · 8c · 8d · 8e · 8f · 8g · 8h · 8i
SP1:                                                
SP2:                                                
SP3:                                                
SP4:                                                
SP5:                                                


ECgene alternative splicing isoforms for NME6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NME6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGACTCTGT
NME6 Expression
About this image


NME6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebral Cortex
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Metencephalon
 
 Thymus (Hematopoietic System)
         Thymus
 
 Eye (Sensory Organs)
         Lens
NME6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NME6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.465558

UniProtKB/Swiss-Prot: NDK6_HUMAN, O75414
Tissue specificity: Expressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary,
intestine, and spleen

    Custom PCR Arrays for NME6
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NME6
QuantiTect SYBR Green Assays in human, mouse, rat NME6
QuantiFast Probe-based Assays in human, mouse, rat NME6
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NME6 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nme61 , 5 non-metastatic cells 6, protein expressed in (nucleoside-diphosphate more5
NME/NM23 nucleoside diphosphate kinase 61
88.28(n)1
91.21(a)1
  9 (59.79 cM)5
543691  NM_018757.11  NP_061227.11 
 1098327495 
chicken
(Gallus gallus)
Aves NME61 NME/NM23 nucleoside diphosphate kinase 6 69.3(n)
69.49(a)
  426866  XM_424474.4  XP_424474.1 
lizard
(Anolis carolinensis)
Reptilia NME66
NME/NM23 nucleoside diphosphate kinase 6
65(a)
1 ↔ 1
GL343765.1(43777-56609)
African clawed frog
(Xenopus laevis)
Amphibia Xl.44672 Xenopus laevis transcribed sequence with weak similarity more 72.44(n)    BX845338.1 
zebrafish
(Danio rerio)
Actinopterygii ndpkz62 nucleoside diphosphate kinase-Z6 72.3(n)   58120  AF241153.1 
fruit fly
(Drosophila melanogaster)
Insecta nmdyn-D61 nmdyn-D6 51.82(n)
47.45(a)
  32396  NM_132737.2  NP_572965.1 


ENSEMBL Gene Tree for NME6 (if available)
TreeFam Gene Tree for NME6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NME6 gene
NME22  NME12  NME32  NME82  NME42  NME72  NME1-NME22  NME92  
NME52  
7 SIMAP similar genes for NME6 using alignment to 6 protein entries:     NDK6_HUMAN (see all proteins):
NME5    NME7    NME4    c371H6.2    NME2    NME3
NME2P1

NME6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NME6 (see all 195)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1392611811,2
--48335189(+) TGCCAC/TGTTAT 1 -- int10--------
rs1436992541,2
--48335240(+) ACCCAA/GTCATG 1 -- int10--------
rs1468081131,2
--48335290(+) AGAATG/TTATGA 1 -- int10--------
rs1904625571,2
--48335433(+) GAGAAG/TTCAGA 1 -- int10--------
rs710742291,2
C--48335576(-) AAAAAA/-AAAAA 1 -- ut311Minor allele frequency- -:0.00NA 2
rs11348671,2
C,F,H--48335808(-) GAGGCG/AGGCGG 1 -- ut318Minor allele frequency- A:0.25NA MN CSA 198
rs31972231,2
C,F,H--48335857(-) AGGCCG/AGGCAC 1 -- ut31 ese322Minor allele frequency- A:0.17NS EA NA MN CSA WA 2526
rs1818400181,2
--48336048(+) AGGCTG/TCCCTG 1 -- ut310--------
rs1861086391,2
--48336063(+) TAGGAC/GAATGT 1 -- ut310--------
rs1889119021,2
C--48336117(+) CTTCAC/TAGACC 1 -- ut310--------

HapMap Linkage Disequilibrium report for NME6 (48334754 - 48343175 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for NME6:    About this table    
Variant IDTypeSubtypePubMed ID
nsv834683CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NME6
DNA2.0 Custom Variant and Variant Library Synthesis for NME6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608294    OMIM disorders: --

5 diseases for NME6:    
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pneumonia    malaria    prostatitis    prostate cancer
cerebritis


NME6 for disorders           About GeneDecksing

Genetic Association Database (GAD): NME6
Human Genome Epidemiology (HuGE) Navigator: NME6 (1 document)

Export disorders for NME6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NME6 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with NME6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. (PubMed id 10453732)1, 2, 3, 9 Mehus J.G.... Lambeth D.O. (Hum. Genet. 1999)
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  3. Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)1, 3 Desvignes T....Bobe J. (BMC Evol. Biol. 2009)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
  6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
  7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  8. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
  9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10201 HGNC: 20567 AceView: NME6 Ensembl:ENSG00000172113 euGenes: HUgn10201
ECgene: NME6 Kegg: 10201 H-InvDB: NME6

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NME6 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NME6 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NME6 gene:
Search GeneIP for patents involving NME6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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