Aliases for NME6 Gene
External Ids for NME6 Gene
Previous GeneCards Identifiers for NME6 Gene
Nucleoside diphosphate (NDP) kinases (EC 22.214.171.124), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]
GeneCards Summary for NME6 Gene
NME6 (NME/NM23 Nucleoside Diphosphate Kinase 6) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and purine nucleotides de novo biosynthesis. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME7.
UniProtKB/Swiss-Prot for NME6 Gene
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.