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Aliases for NME6 Gene

Aliases for NME6 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 6 2 3 5
  • Non-Metastatic Cells 6, Protein Expressed In (Nucleoside-Diphosphate Kinase) 2 3
  • Inhibitor Of P53-Induced Apoptosis-Alpha 3 4
  • NDP Kinase 6 3 4
  • IPIA-ALPHA 3 4
  • EC 2.7.4.6 4 63
  • NM23-H6 3 4
  • NDK 6 3 4

External Ids for NME6 Gene

Previous GeneCards Identifiers for NME6 Gene

  • GC03M047618
  • GC03M048154
  • GC03M048296
  • GC03M048311
  • GC03M048334
  • GC03M048289

Summaries for NME6 Gene

Entrez Gene Summary for NME6 Gene

  • Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]

GeneCards Summary for NME6 Gene

NME6 (NME/NM23 Nucleoside Diphosphate Kinase 6) is a Protein Coding gene. Among its related pathways are Metabolism and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME6 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME6 Gene

Genomics for NME6 Gene

Regulatory Elements for NME6 Gene

Promoters for NME6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NME6 on UCSC Golden Path with GeneCards custom track

Genomic Location for NME6 Gene

Chromosome:
3
Start:
48,292,317 bp from pter
End:
48,302,246 bp from pter
Size:
9,930 bases
Orientation:
Minus strand

Genomic View for NME6 Gene

Genes around NME6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME6 Gene

Proteins for NME6 Gene

  • Protein details for NME6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75414-NDK6_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase 6
    Protein Accession:
    O75414
    Secondary Accessions:
    • B4DGW7
    • B4DM99
    • Q53HM5
    • Q96E73
    • Q9BQ63

    Protein attributes for NME6 Gene

    Size:
    186 amino acids
    Molecular mass:
    21142 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC69439.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH01808.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12828.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96275.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NME6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NME6 Gene

Proteomics data for NME6 Gene at MOPED

Selected DME Specific Peptides for NME6 Gene

Post-translational modifications for NME6 Gene

No Post-translational modifications

Antibody Products

Domains & Families for NME6 Gene

Gene Families for NME6 Gene

Protein Domains for NME6 Gene

Suggested Antigen Peptide Sequences for NME6 Gene

Graphical View of Domain Structure for InterPro Entry

O75414

UniProtKB/Swiss-Prot:

NDK6_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME6: view

Function for NME6 Gene

Molecular function for NME6 Gene

GENATLAS Biochemistry:
non-metastatic cells 6,protein,with a nm23 nucleoside diphosphate kinase gene family,predominantly expressed in kidney,prostate,ovary,intestine
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

Enzyme Numbers (IUBMB) for NME6 Gene

Gene Ontology (GO) - Molecular Function for NME6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NME6: view
genes like me logo Genes that share phenotypes with NME6: view

Animal Models for NME6 Gene

MGI Knock Outs for NME6:
  • Nme6 tm1.1(KOMP)Vlcg

Animal Model Products

  • Taconic Biosciences Mouse Models for NME6

miRNA for NME6 Gene

miRTarBase miRNAs that target NME6

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NME6 Gene

Localization for NME6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NME6 Gene COMPARTMENTS Subcellular localization image for NME6 gene
Compartment Confidence
mitochondrion 5
cytosol 3
cytoskeleton 2
nucleus 2
peroxisome 2
chloroplast 1
extracellular 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NME6 Gene

Pathways & Interactions for NME6 Gene

genes like me logo Genes that share pathways with NME6: view

Gene Ontology (GO) - Biological Process for NME6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006915 apoptotic process IEA --
GO:0030308 negative regulation of cell growth IDA 10618642
GO:0045839 negative regulation of mitotic nuclear division IDA 10618642
genes like me logo Genes that share ontologies with NME6: view

No data available for SIGNOR curated interactions for NME6 Gene

Drugs & Compounds for NME6 Gene

(11) Drugs for NME6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
dctp Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0

(12) Additional Compounds for NME6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxy-Inosine 5'-(tetrahydrogen triphosphate)
  • 2'-Deoxyinosine-5'-triphosphate
  • 2'-Ditp
  • Deoxyinosine 5'-triphosphate
  • Deoxyinosine triphosphate
16595-02-1
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
1173-82-6
genes like me logo Genes that share compounds with NME6: view

Transcripts for NME6 Gene

Unigene Clusters for NME6 Gene

NME/NM23 nucleoside diphosphate kinase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NME6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - -
SP17: - - - - - - -
SP18: - - - - - - - - -
SP19: - - - - - -

ExUns: 8b · 8c · 8d · 8e · 8f · 8g · 8h · 8i
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for NME6 Gene

GeneLoc Exon Structure for
NME6
ECgene alternative splicing isoforms for
NME6

Expression for NME6 Gene

mRNA expression in normal human tissues for NME6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NME6 Gene

This gene is overexpressed in Bone (28.2), Peripheral blood mononuclear cells (8.2), Tlymphocyte (7.6), and Lymph node (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NME6 Gene



SOURCE GeneReport for Unigene cluster for NME6 Gene Hs.465558

mRNA Expression by UniProt/SwissProt for NME6 Gene

O75414-NDK6_HUMAN
Tissue specificity: Expressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary, intestine, and spleen.
genes like me logo Genes that share expression patterns with NME6: view

Protein tissue co-expression partners for NME6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NME6 Gene

Orthologs for NME6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NME6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NME6 36
  • 98 (a)
OneToOne
NME6 35
  • 99.82 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia LOC509354 35
  • 87.81 (n)
  • 93.01 (a)
NME6 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NME6 36
  • 92 (a)
OneToOne
NME6 35
  • 91.24 (n)
  • 94.29 (a)
mouse
(Mus musculus)
Mammalia Nme6 36
  • 88 (a)
OneToOne
Nme6 16
Nme6 35
  • 88.28 (n)
  • 91.21 (a)
oppossum
(Monodelphis domestica)
Mammalia NME6 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 1 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Nme6 35
  • 88.35 (n)
  • 91.4 (a)
chicken
(Gallus gallus)
Aves NME6 35
  • 69.3 (n)
  • 69.49 (a)
NME6 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NME6 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4467 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nme6 35
  • 65.16 (n)
  • 67.8 (a)
Str.16794 35
zebrafish
(Danio rerio)
Actinopterygii ndpkz6 35
nme6 35
  • 64.19 (n)
  • 60 (a)
nme6 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005123 35
  • 47.71 (n)
  • 38.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta nmdyn-D6 35
  • 51.82 (n)
  • 47.45 (a)
nmdyn-D6 36
  • 46 (a)
OneToMany
Species with no ortholog for NME6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NME6 Gene

ENSEMBL:
Gene Tree for NME6 (if available)
TreeFam:
Gene Tree for NME6 (if available)

Paralogs for NME6 Gene

Paralogs for NME6 Gene

(7) SIMAP similar genes for NME6 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NME6: view

Variants for NME6 Gene

Sequence variations from dbSNP and Humsavar for NME6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1134866 -- 48,294,550(-) CCTGG(C/G/T)TTACA nc-transcript-variant, utr-variant-3-prime
rs1134867 -- 48,294,318(-) GAGGC(A/G)GGCGG nc-transcript-variant, utr-variant-3-prime
rs4511915 -- 48,302,368(+) ACTTC(A/G)GTGTC upstream-variant-2KB
rs4392440 -- 48,302,430(+) CTGTC(C/T)CTGCA upstream-variant-2KB
rs4479622 -- 48,296,683(+) GGCCT(C/T)TTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NME6 Gene

Variant ID Type Subtype PubMed ID
nsv834683 CNV Gain 17160897

Variation tolerance for NME6 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 15.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME6 Gene

HapMap Linkage Disequilibrium report
NME6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NME6 Gene

Disorders for NME6 Gene

Relevant External Links for NME6

Genetic Association Database (GAD)
NME6
Human Genome Epidemiology (HuGE) Navigator
NME6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NME6

No disorders were found for NME6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NME6 Gene

Publications for NME6 Gene

  1. NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. (PMID: 10453732) Mehus J.G. … Lambeth D.O. (Hum. Genet. 1999) 2 3 4 23 67
  2. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T. … Bobe J. (BMC Evol. Biol. 2009) 2 3
  3. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. (PMID: 25496667) Landi A. … Verhasselt B. (Retrovirology 2014) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for NME6 Gene

Sources for NME6 Gene

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