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Aliases for NME6 Gene

Aliases for NME6 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 6 2 3 5
  • Non-Metastatic Cells 6, Protein Expressed In (Nucleoside-Diphosphate Kinase) 2 3
  • Inhibitor Of P53-Induced Apoptosis-Alpha 3 4
  • NDP Kinase 6 3 4
  • IPIA-ALPHA 3 4
  • EC 2.7.4.6 4 58
  • NM23-H6 3 4
  • NDK 6 3 4
  • Nucleoside Diphosphate Kinase 6 3

External Ids for NME6 Gene

Previous GeneCards Identifiers for NME6 Gene

  • GC03M047618
  • GC03M048154
  • GC03M048296
  • GC03M048311
  • GC03M048334
  • GC03M048289

Summaries for NME6 Gene

Entrez Gene Summary for NME6 Gene

  • Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]

GeneCards Summary for NME6 Gene

NME6 (NME/NM23 Nucleoside Diphosphate Kinase 6) is a Protein Coding gene. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Pyrimidine metabolism (KEGG). GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME6 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

Additional gene information for NME6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME6 Gene

Genomics for NME6 Gene

Regulatory Elements for NME6 Gene

Enhancers for NME6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H047379 1.2 ENCODE 27.7 +921.6 921558 3 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SETD2 NME6 ZNF589 MRPS18AP1 BOLA2P2 PTPN23 CCDC12 NBEAL2 SCAP SMARCC1
GH03H047441 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.9 +859.1 859148 3 FOXA2 ATF1 ARID4B SIN3A YY1 FOS KLF7 ATF7 SP5 REST NME6 SETD2 PTPN23 NBEAL2 SCAP ZNF589 MRPS18AP1 CCDC12 ELP6 BOLA2P2
GH03H047778 1.4 Ensembl ENCODE 16.8 +521.4 521446 5 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF589 SETD2 PTPN23 DHX30 ATRIP BOLA2P2 SCAP IP6K2 CCDC12 NME6
GH03H048439 1.1 ENCODE 20 -138.5 -138504 3 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 FOS SP3 TMA7 ATRIP QRICH1 USP19 CCDC36 ENSG00000225399 NME6 SHISA5 PRKAR2A DHX30
GH03H047788 1.3 Ensembl ENCODE 16.8 +513.2 513184 1 HDGF PKNOX1 FOXA2 ARNT SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 ZNF589 CCDC12 NME6 SETD2 PTPN23 MRPS18AP1 ATRIP BOLA2P2 SCAP IP6K2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NME6 on UCSC Golden Path with GeneCards custom track

Promoters for NME6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152093 746 1801 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 SP3

Genomic Location for NME6 Gene

Chromosome:
3
Start:
48,292,317 bp from pter
End:
48,302,246 bp from pter
Size:
9,930 bases
Orientation:
Minus strand

Genomic View for NME6 Gene

Genes around NME6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME6 Gene

Proteins for NME6 Gene

  • Protein details for NME6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75414-NDK6_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase 6
    Protein Accession:
    O75414
    Secondary Accessions:
    • B4DGW7
    • B4DM99
    • Q53HM5
    • Q96E73
    • Q9BQ63

    Protein attributes for NME6 Gene

    Size:
    186 amino acids
    Molecular mass:
    21142 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC69439.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH01808.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12828.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96275.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NME6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NME6 Gene

Selected DME Specific Peptides for NME6 Gene

O75414:
  • IKPDAVA
  • AHPLILEA
  • GLTDTRNTTHGSDS
  • GRFFYQRLVEFM

Post-translational modifications for NME6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NME6 Gene

Gene Families for NME6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NME6 Gene

Graphical View of Domain Structure for InterPro Entry

O75414

UniProtKB/Swiss-Prot:

NDK6_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME6: view

Function for NME6 Gene

Molecular function for NME6 Gene

GENATLAS Biochemistry:
non-metastatic cells 6,protein,with a nm23 nucleoside diphosphate kinase gene family,predominantly expressed in kidney,prostate,ovary,intestine
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

Enzyme Numbers (IUBMB) for NME6 Gene

Phenotypes From GWAS Catalog for NME6 Gene

Gene Ontology (GO) - Molecular Function for NME6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity TAS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NME6: view
genes like me logo Genes that share phenotypes with NME6: view

Animal Models for NME6 Gene

MGI Knock Outs for NME6:
  • Nme6 tm1.1(KOMP)Vlcg

Animal Model Products

  • Taconic Biosciences Mouse Models for NME6

CRISPR Products

miRNA for NME6 Gene

miRTarBase miRNAs that target NME6

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NME6
  • Applied Biological Materials Clones for NME6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NME6 Gene

Localization for NME6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NME6 gene
Compartment Confidence
mitochondrion 5
cytosol 5
peroxisome 2
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NME6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 10618642
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NME6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NME6 Gene

Pathways & Interactions for NME6 Gene

genes like me logo Genes that share pathways with NME6: view

Gene Ontology (GO) - Biological Process for NME6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with NME6: view

No data available for SIGNOR curated interactions for NME6 Gene

Drugs & Compounds for NME6 Gene

(11) Drugs for NME6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
dATP Experimental Pharma Full agonist, Agonist 0
dctp Experimental Pharma 0
dgtp Experimental Pharma 0

(12) Additional Compounds for NME6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxy-Inosine 5'-(tetrahydrogen triphosphate)
  • 2'-Deoxyinosine-5'-triphosphate
  • 2'-Ditp
  • Deoxyinosine 5'-triphosphate
  • Deoxyinosine triphosphate
16595-02-1
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
1173-82-6
genes like me logo Genes that share compounds with NME6: view

Transcripts for NME6 Gene

Unigene Clusters for NME6 Gene

NME/NM23 nucleoside diphosphate kinase 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NME6
  • Applied Biological Materials Clones for NME6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NME6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - -
SP17: - - - - - - -
SP18: - - - - - - - - -
SP19: - - - - - -

ExUns: 8b · 8c · 8d · 8e · 8f · 8g · 8h · 8i
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for NME6 Gene

GeneLoc Exon Structure for
NME6
ECgene alternative splicing isoforms for
NME6

Expression for NME6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NME6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NME6 Gene

This gene is overexpressed in Bone (28.2), Peripheral blood mononuclear cells (8.2), Tlymphocyte (7.6), and Lymph node (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NME6 Gene



Protein tissue co-expression partners for NME6 Gene

NURSA nuclear receptor signaling pathways regulating expression of NME6 Gene:

NME6

SOURCE GeneReport for Unigene cluster for NME6 Gene:

Hs.465558

mRNA Expression by UniProt/SwissProt for NME6 Gene:

O75414-NDK6_HUMAN
Tissue specificity: Expressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary, intestine, and spleen.

Evidence on tissue expression from TISSUES for NME6 Gene

  • Liver(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with NME6: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NME6 Gene

Orthologs for NME6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NME6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NME6 33 34
  • 99.82 (n)
cow
(Bos Taurus)
Mammalia NME6 34
  • 95 (a)
OneToOne
LOC509354 33
  • 87.81 (n)
dog
(Canis familiaris)
Mammalia NME6 33 34
  • 91.24 (n)
rat
(Rattus norvegicus)
Mammalia Nme6 33
  • 88.35 (n)
mouse
(Mus musculus)
Mammalia Nme6 33 16 34
  • 88.28 (n)
oppossum
(Monodelphis domestica)
Mammalia NME6 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 1 (a)
ManyToMany
chicken
(Gallus gallus)
Aves NME6 33 34
  • 69.3 (n)
lizard
(Anolis carolinensis)
Reptilia NME6 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nme6 33
  • 65.16 (n)
Str.16794 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4467 33
zebrafish
(Danio rerio)
Actinopterygii nme6 33 34
  • 64.19 (n)
ndpkz6 33
fruit fly
(Drosophila melanogaster)
Insecta nmdyn-D6 33 34
  • 51.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005123 33
  • 47.71 (n)
Species where no ortholog for NME6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NME6 Gene

ENSEMBL:
Gene Tree for NME6 (if available)
TreeFam:
Gene Tree for NME6 (if available)

Paralogs for NME6 Gene

Paralogs for NME6 Gene

(7) SIMAP similar genes for NME6 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NME6: view

Variants for NME6 Gene

Sequence variations from dbSNP and Humsavar for NME6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000184162 -- 48,303,740(+) CTGTG(A/T)CACAT upstream-variant-2KB
rs1000337521 -- 48,297,263(+) CAAGG(A/T)TATAC intron-variant, upstream-variant-2KB
rs1000455184 -- 48,296,811(+) GCTTA(C/G)AATCT intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000669753 -- 48,299,005(+) TGAGG(G/T)GCTAC intron-variant
rs1000701622 -- 48,303,317(+) GCAAC(A/C)AACTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NME6 Gene

Variant ID Type Subtype PubMed ID
nsv834683 CNV gain 17160897

Variation tolerance for NME6 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 15.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NME6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NME6 Gene

Disorders for NME6 Gene

Relevant External Links for NME6

Genetic Association Database (GAD)
NME6
Human Genome Epidemiology (HuGE) Navigator
NME6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NME6

No disorders were found for NME6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NME6 Gene

Publications for NME6 Gene

  1. NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. (PMID: 10453732) Mehus JG … Lambeth DO (Human genetics 1999) 2 3 4 22 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T … Bobe J (BMC evolutionary biology 2009) 2 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for NME6 Gene

  • Addgene plasmids for NME6

Sources for NME6 Gene

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