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Aliases for NME6 Gene

Aliases for NME6 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 6 2 3
  • Non-Metastatic Cells 6, Protein Expressed In (Nucleoside-Diphosphate Kinase) 2 3
  • Inhibitor Of P53-Induced Apoptosis-Alpha 3 4
  • NDP Kinase 6 3 4
  • IPIA-ALPHA 3 4
  • EC 2.7.4.6 4 63
  • NM23-H6 3 4
  • NDK 6 3 4
  • Nucleoside Diphosphate Kinase 6 3

External Ids for NME6 Gene

Previous GeneCards Identifiers for NME6 Gene

  • GC03M047618
  • GC03M048154
  • GC03M048296
  • GC03M048311
  • GC03M048334

Summaries for NME6 Gene

Entrez Gene Summary for NME6 Gene

  • Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]

GeneCards Summary for NME6 Gene

NME6 (NME/NM23 Nucleoside Diphosphate Kinase 6) is a Protein Coding gene. Among its related pathways are Metabolism and purine nucleotide salvage. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME6 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME6 Gene

Genomics for NME6 Gene

Regulatory Elements for NME6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NME6 Gene

Start:
48,289,575 bp from pter
End:
48,302,229 bp from pter
Size:
12,655 bases
Orientation:
Minus strand

Genomic View for NME6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NME6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME6 Gene

Proteins for NME6 Gene

  • Protein details for NME6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75414-NDK6_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase 6
    Protein Accession:
    O75414
    Secondary Accessions:
    • B4DGW7
    • B4DM99
    • Q53HM5
    • Q96E73
    • Q9BQ63

    Protein attributes for NME6 Gene

    Size:
    186 amino acids
    Molecular mass:
    21142 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC69439.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH01808.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12828.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96275.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NME6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NME6 Gene

Proteomics data for NME6 Gene at MOPED

Selected DME Specific Peptides for NME6 Gene

Post-translational modifications for NME6 Gene

No Post-translational modifications

Domains for NME6 Gene

Protein Domains for NME6 Gene

Suggested Antigen Peptide Sequences for NME6 Gene

Graphical View of Domain Structure for InterPro Entry

O75414

UniProtKB/Swiss-Prot:

NDK6_HUMAN :
  • O75414
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME6: view

No data available for Gene Families for NME6 Gene

Function for NME6 Gene

Molecular function for NME6 Gene

GENATLAS Biochemistry: non-metastatic cells 6,protein,with a nm23 nucleoside diphosphate kinase gene family,predominantly expressed in kidney,prostate,ovary,intestine
UniProtKB/Swiss-Prot CatalyticActivity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis

Enzyme Numbers (IUBMB) for NME6 Gene

Gene Ontology (GO) - Molecular Function for NME6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IDA 10618642
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NME6: view

Animal Model Products

CRISPR Products

miRNA for NME6 Gene

miRTarBase miRNAs that target NME6

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NME6 Gene

Localization for NME6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NME6 Gene COMPARTMENTS Subcellular localization image for NME6 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NME6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 10618642
genes like me logo Genes that share ontologies with NME6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NME6 Gene

Pathways for NME6 Gene

genes like me logo Genes that share pathways with NME6: view

Gene Ontology (GO) - Biological Process for NME6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with NME6: view

Compounds for NME6 Gene

(23) HMDB Compounds for NME6 Gene

Compound Synonyms Cas Number PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxyinosine-5'-triphosphate
16595-02-1
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
CDP
  • CDP
63-38-7
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)
65-47-4
genes like me logo Genes that share compounds with NME6: view

Transcripts for NME6 Gene

Unigene Clusters for NME6 Gene

NME/NM23 nucleoside diphosphate kinase 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NME6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - -
SP17: - - - - - - -
SP18: - - - - - - - - -
SP19: - - - - - -

ExUns: 8b · 8c · 8d · 8e · 8f · 8g · 8h · 8i
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for NME6 Gene

GeneLoc Exon Structure for
NME6
ECgene alternative splicing isoforms for
NME6

Expression for NME6 Gene

mRNA expression in normal human tissues for NME6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NME6 Gene

SOURCE GeneReport for Unigene cluster for NME6 Gene Hs.465558

mRNA Expression by UniProt/SwissProt for NME6 Gene

O75414-NDK6_HUMAN
Tissue specificity: Expressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary, intestine, and spleen
genes like me logo Genes that share expressions with NME6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NME6 Gene

Orthologs for NME6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NME6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NME6 35
  • 99.82 (n)
  • 100 (a)
NME6 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC509354 35
  • 87.81 (n)
  • 93.01 (a)
NME6 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NME6 35
  • 91.24 (n)
  • 94.29 (a)
NME6 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nme6 35
  • 88.28 (n)
  • 91.21 (a)
Nme6 16
Nme6 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NME6 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 1 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Nme6 35
  • 88.35 (n)
  • 91.4 (a)
chicken
(Gallus gallus)
Aves NME6 35
  • 69.3 (n)
  • 69.49 (a)
NME6 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NME6 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4467 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nme6 35
  • 65.16 (n)
  • 67.8 (a)
Str.16794 35
zebrafish
(Danio rerio)
Actinopterygii ndpkz6 35
nme6 35
  • 64.19 (n)
  • 60 (a)
nme6 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005123 35
  • 47.71 (n)
  • 38.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta nmdyn-D6 35
  • 51.82 (n)
  • 47.45 (a)
nmdyn-D6 36
  • 46 (a)
OneToMany
Species with no ortholog for NME6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NME6 Gene

ENSEMBL:
Gene Tree for NME6 (if available)
TreeFam:
Gene Tree for NME6 (if available)

Paralogs for NME6 Gene

Paralogs for NME6 Gene

Selected SIMAP similar genes for NME6 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NME6: view

Variants for NME6 Gene

Sequence variations from dbSNP and Humsavar for NME6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2541 -- 48,298,128(-) ACACT(C/T)ATTTG intron-variant
rs1134866 -- 48,294,550(-) CCTGG(C/G)TTACA utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1134867 -- 48,294,318(-) GAGGC(A/G)GGCGG utr-variant-3-prime, intron-variant, nc-transcript-variant
rs3197223 -- 48,294,367(-) AGGCC(A/G)GGCAC utr-variant-3-prime, intron-variant, nc-transcript-variant
rs4336143 -- 48,303,277(+) TGATA(C/T)AGATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NME6 Gene

Variant ID Type Subtype PubMed ID
nsv834683 CNV Gain 17160897

Relevant External Links for NME6 Gene

HapMap Linkage Disequilibrium report
NME6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NME6 Gene

Disorders for NME6 Gene

Relevant External Links for NME6

Genetic Association Database (GAD)
NME6
Human Genome Epidemiology (HuGE) Navigator
NME6
genes like me logo Genes that share disorders with NME6: view

No data available for UniProtKB/Swiss-Prot for NME6 Gene

Publications for NME6 Gene

  1. NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. (PMID: 10453732) Mehus J.G. … Lambeth D.O. (Hum. Genet. 1999) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T. … Bobe J. (BMC Evol. Biol. 2009) 2 3
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for NME6 Gene

  • Addgene plasmids for NME6

Sources for NME6 Gene

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