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Aliases for NME5 Gene

Aliases for NME5 Gene

  • NME/NM23 Family Member 5 2 3
  • Non-Metastatic Cells 5, Protein Expressed In (Nucleoside-Diphosphate Kinase) 2 3
  • Inhibitor Of P53-Induced Apoptosis-Beta 3 4
  • Testis-Specific Nm23 Homolog 3 4
  • NDP Kinase Homolog 5 3 4
  • IPIA-Beta 3 4
  • NDK-H 5 3 4
  • NM23-H5 3 4
  • Radial Spoke 23 Homolog (Chlamydomonas) 2
  • Radial Spoke 23 Homolog 3
  • NM23H5 3
  • RSPH23 3

External Ids for NME5 Gene

Previous GeneCards Identifiers for NME5 Gene

  • GC05M137326
  • GC05M138126
  • GC05M137481
  • GC05M137527
  • GC05M137478
  • GC05M137451
  • GC05M132641

Summaries for NME5 Gene

GeneCards Summary for NME5 Gene

NME5 (NME/NM23 Family Member 5) is a Protein Coding gene. Among its related pathways are Carbon metabolism and Metabolism. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME5 Gene

  • Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME5 Gene

Genomics for NME5 Gene

Regulatory Elements for NME5 Gene

Genomic Location for NME5 Gene

Chromosome:
5
Start:
138,115,172 bp from pter
End:
138,139,443 bp from pter
Size:
24,272 bases
Orientation:
Minus strand

Genomic View for NME5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NME5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME5 Gene

Proteins for NME5 Gene

  • Protein details for NME5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56597-NDK5_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase homolog 5
    Protein Accession:
    P56597
    Secondary Accessions:
    • B2R5G7

    Protein attributes for NME5 Gene

    Size:
    212 amino acids
    Molecular mass:
    24236 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NME5 Gene

Proteomics data for NME5 Gene at MOPED

Post-translational modifications for NME5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NME5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NME5 Gene

Domains & Families for NME5 Gene

Gene Families for NME5 Gene

Protein Domains for NME5 Gene

Suggested Antigen Peptide Sequences for NME5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56597

UniProtKB/Swiss-Prot:

NDK5_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME5: view

Function for NME5 Gene

Molecular function for NME5 Gene

GENATLAS Biochemistry:
non-metastatic cells 5,protein,with a nm23 nucleoside diphosphate kinase gene family,specifically expressed in testis germinal cells,expressed in germ cell,kidney,ovary,parathyroid,testis,uterus,involved in the phosphorylation of nucleoside diphosphates and putatively in spermatogenesis
UniProtKB/Swiss-Prot Function:
Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).

Gene Ontology (GO) - Molecular Function for NME5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding --
genes like me logo Genes that share ontologies with NME5: view
genes like me logo Genes that share phenotypes with NME5: view

Animal Models for NME5 Gene

MGI Knock Outs for NME5:

Animal Model Products

miRNA for NME5 Gene

miRTarBase miRNAs that target NME5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NME5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NME5 Gene

Localization for NME5 Gene

Gene Ontology (GO) - Cellular Components for NME5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IBA --
GO:0036126 sperm flagellum IEA --
genes like me logo Genes that share ontologies with NME5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for NME5 Gene

Pathways & Interactions for NME5 Gene

genes like me logo Genes that share pathways with NME5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis in human,mouse,rat
    • Apoptosis 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for NME5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement IEA --
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
genes like me logo Genes that share ontologies with NME5: view

No data available for SIGNOR curated interactions for NME5 Gene

Drugs & Compounds for NME5 Gene

(10) Drugs for NME5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
dctp Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0

(12) Additional Compounds for NME5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxy-Inosine 5'-(tetrahydrogen triphosphate)
  • 2'-Deoxyinosine-5'-triphosphate
  • 2'-Ditp
  • Deoxyinosine 5'-triphosphate
  • Deoxyinosine triphosphate
16595-02-1
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
1173-82-6
genes like me logo Genes that share compounds with NME5: view

Transcripts for NME5 Gene

Unigene Clusters for NME5 Gene

NME/NM23 family member 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NME5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - -
SP3:

Relevant External Links for NME5 Gene

GeneLoc Exon Structure for
NME5
ECgene alternative splicing isoforms for
NME5

Expression for NME5 Gene

mRNA expression in normal human tissues for NME5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NME5 Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for NME5 Gene

This gene is overexpressed in Plasma (57.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NME5 Gene



SOURCE GeneReport for Unigene cluster for NME5 Gene Hs.730856

mRNA Expression by UniProt/SwissProt for NME5 Gene

P56597-NDK5_HUMAN
Tissue specificity: Specifically expressed in testis germinal cells
genes like me logo Genes that share expression patterns with NME5: view

Protein tissue co-expression partners for NME5 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for NME5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NME5 35
  • 91.55 (n)
  • 90.43 (a)
NME5 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NME5 35
  • 90.68 (n)
  • 89.57 (a)
mouse
(Mus musculus)
Mammalia Nme5 35
  • 83.57 (n)
  • 86.26 (a)
Nme5 16
Nme5 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NME5 35
  • 99.37 (n)
  • 98.58 (a)
NME5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nme5 35
  • 84.04 (n)
  • 88.15 (a)
oppossum
(Monodelphis domestica)
Mammalia NME5 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NME5 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NME5 35
  • 71.45 (n)
  • 75.12 (a)
NME5 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NME5 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nme5 35
  • 72.04 (n)
  • 72.99 (a)
Str.14959 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17997 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14439 35
nme5 35
  • 65.05 (n)
  • 66.02 (a)
nme5 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5032 35
fruit fly
(Drosophila melanogaster)
Insecta nmdyn-D6 36
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G17410 35
  • 49.65 (n)
  • 43.36 (a)
rice
(Oryza sativa)
Liliopsida Os02g0565100 35
  • 49.25 (n)
  • 46.27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6539 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for NME5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NME5 Gene

ENSEMBL:
Gene Tree for NME5 (if available)
TreeFam:
Gene Tree for NME5 (if available)

Paralogs for NME5 Gene

Paralogs for NME5 Gene

(3) SIMAP similar genes for NME5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NME5: view

Variants for NME5 Gene

Variation tolerance for NME5 Gene

Residual Variation Intolerance Score: 58.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME5 Gene

HapMap Linkage Disequilibrium report
NME5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for NME5 Gene

Disorders for NME5 Gene

Relevant External Links for NME5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NME5
genes like me logo Genes that share disorders with NME5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NME5 Gene

Publications for NME5 Gene

  1. A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells. (PMID: 9742940) Munier A. … Lacombe M.-L. (FEBS Lett. 1998) 2 23 67
  2. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T. … Bobe J. (BMC Evol. Biol. 2009) 2 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Transactivation of the human NME5 gene by Sp1 in pancreatic cancer cells. (PMID: 22564704) Li F. … Zhang L. (Gene 2012) 67
  5. Shifted Transversal Design smart-pooling for high coverage interactome mapping. (PMID: 19447967) Xin X. … Thierry-Mieg N. (Genome Res. 2009) 67

Products for NME5 Gene

Sources for NME5 Gene

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