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Aliases for NME5 Gene

Aliases for NME5 Gene

  • NME/NM23 Family Member 5 2 3 5
  • Non-Metastatic Cells 5, Protein Expressed In (Nucleoside-Diphosphate Kinase) 2 3
  • Inhibitor Of P53-Induced Apoptosis-Beta 3 4
  • Testis-Specific Nm23 Homolog 3 4
  • NDP Kinase Homolog 5 3 4
  • IPIA-Beta 3 4
  • NDK-H 5 3 4
  • NM23-H5 3 4
  • Non-Metastatic Cells 5 Protein Expressed In 3
  • Radial Spoke 23 Homolog (Chlamydomonas) 2
  • Radial Spoke 23 Homolog 3
  • NM23H5 3
  • RSPH23 3

External Ids for NME5 Gene

Previous GeneCards Identifiers for NME5 Gene

  • GC05M137326
  • GC05M138126
  • GC05M137481
  • GC05M137527
  • GC05M137478
  • GC05M137451
  • GC05M132641

Summaries for NME5 Gene

GeneCards Summary for NME5 Gene

NME5 (NME/NM23 Family Member 5) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and purine nucleotides de novo biosynthesis. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME5 Gene

  • Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME5 Gene

Genomics for NME5 Gene

Regulatory Elements for NME5 Gene

Enhancers for NME5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NME5 on UCSC Golden Path with GeneCards custom track

Promoters for NME5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NME5 on UCSC Golden Path with GeneCards custom track

Genomic Location for NME5 Gene

138,115,172 bp from pter
138,139,443 bp from pter
24,272 bases
Minus strand

Genomic View for NME5 Gene

Genes around NME5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME5 Gene

Proteins for NME5 Gene

  • Protein details for NME5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleoside diphosphate kinase homolog 5
    Protein Accession:
    Secondary Accessions:
    • B2R5G7

    Protein attributes for NME5 Gene

    212 amino acids
    Molecular mass:
    24236 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NME5 Gene

Proteomics data for NME5 Gene at MOPED

Post-translational modifications for NME5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NME5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NME5 Gene

Domains & Families for NME5 Gene

Gene Families for NME5 Gene

Protein Domains for NME5 Gene

Suggested Antigen Peptide Sequences for NME5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NDK family.
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME5: view

Function for NME5 Gene

Molecular function for NME5 Gene

GENATLAS Biochemistry:
non-metastatic cells 5,protein,with a nm23 nucleoside diphosphate kinase gene family,specifically expressed in testis germinal cells,expressed in germ cell,kidney,ovary,parathyroid,testis,uterus,involved in the phosphorylation of nucleoside diphosphates and putatively in spermatogenesis
UniProtKB/Swiss-Prot Function:
Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).
genes like me logo Genes that share phenotypes with NME5: view

Animal Models for NME5 Gene

MGI Knock Outs for NME5:

Animal Model Products

  • Taconic Biosciences Mouse Models for NME5

miRNA for NME5 Gene

miRTarBase miRNAs that target NME5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NME5 Gene

Localization for NME5 Gene

Subcellular locations from

Jensen Localization Image for NME5 Gene COMPARTMENTS Subcellular localization image for NME5 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NME5 Gene

Pathways & Interactions for NME5 Gene

genes like me logo Genes that share pathways with NME5: view

Gene Ontology (GO) - Biological Process for NME5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0007283 spermatogenesis TAS 9742940
GO:0009116 nucleoside metabolic process TAS 9742940
GO:0021591 ventricular system development IEA --
genes like me logo Genes that share ontologies with NME5: view

No data available for SIGNOR curated interactions for NME5 Gene

Drugs & Compounds for NME5 Gene

(10) Drugs for NME5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
dctp Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0

(12) Additional Compounds for NME5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxy-Inosine 5'-(tetrahydrogen triphosphate)
  • 2'-Deoxyinosine-5'-triphosphate
  • 2'-Ditp
  • Deoxyinosine 5'-triphosphate
  • Deoxyinosine triphosphate
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
genes like me logo Genes that share compounds with NME5: view

Transcripts for NME5 Gene

Unigene Clusters for NME5 Gene

NME/NM23 family member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NME5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - -

Relevant External Links for NME5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NME5 Gene

mRNA expression in normal human tissues for NME5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NME5 Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for NME5 Gene

This gene is overexpressed in Plasma (57.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NME5 Gene

SOURCE GeneReport for Unigene cluster for NME5 Gene Hs.730856

mRNA Expression by UniProt/SwissProt for NME5 Gene

Tissue specificity: Specifically expressed in testis germinal cells.
genes like me logo Genes that share expression patterns with NME5: view

Protein tissue co-expression partners for NME5 Gene

- Elite partner

Primer Products

Orthologs for NME5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NME5 35
  • 91.55 (n)
  • 90.43 (a)
NME5 36
  • 91 (a)
(Canis familiaris)
Mammalia NME5 35
  • 90.68 (n)
  • 89.57 (a)
(Mus musculus)
Mammalia Nme5 35
  • 83.57 (n)
  • 86.26 (a)
Nme5 16
Nme5 36
  • 86 (a)
(Pan troglodytes)
Mammalia NME5 35
  • 99.37 (n)
  • 98.58 (a)
NME5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nme5 35
  • 84.04 (n)
  • 88.15 (a)
(Monodelphis domestica)
Mammalia NME5 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia NME5 36
  • 76 (a)
(Gallus gallus)
Aves NME5 35
  • 71.45 (n)
  • 75.12 (a)
NME5 36
  • 74 (a)
(Anolis carolinensis)
Reptilia NME5 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nme5 35
  • 72.04 (n)
  • 72.99 (a)
Str.14959 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17997 35
(Danio rerio)
Actinopterygii Dr.14439 35
nme5 35
  • 65.05 (n)
  • 66.02 (a)
nme5 36
  • 64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5032 35
fruit fly
(Drosophila melanogaster)
Insecta nmdyn-D6 36
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G17410 35
  • 49.65 (n)
  • 43.36 (a)
(Oryza sativa)
Liliopsida Os02g0565100 35
  • 49.25 (n)
  • 46.27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6539 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for NME5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NME5 Gene

Gene Tree for NME5 (if available)
Gene Tree for NME5 (if available)

Paralogs for NME5 Gene

Paralogs for NME5 Gene

(3) SIMAP similar genes for NME5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NME5: view

Variants for NME5 Gene

Sequence variations from dbSNP and Humsavar for NME5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1048921 -- 138,115,648(-) TGAAC(A/T)ATCTT downstream-variant-500B, utr-variant-3-prime
rs1048930 -- 138,115,582(-) ACTAC(A/C)AGTAA utr-variant-3-prime
rs184268 -- 138,126,970(+) taaaa(A/G)CTAAC intron-variant, downstream-variant-500B
rs188654 -- 138,123,883(+) gccaa(A/T)attta intron-variant
rs191968 -- 138,125,423(+) aaaat(C/T)aaaaa intron-variant

Variation tolerance for NME5 Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NME5 Gene

Disorders for NME5 Gene

Relevant External Links for NME5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NME5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NME5 Gene

Publications for NME5 Gene

  1. A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells. (PMID: 9742940) Munier A. … Lacombe M.-L. (FEBS Lett. 1998) 2 3 4 23 67
  2. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T. … Bobe J. (BMC Evol. Biol. 2009) 2 3
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Transactivation of the human NME5 gene by Sp1 in pancreatic cancer cells. (PMID: 22564704) Li F. … Zhang L. (Gene 2012) 3

Products for NME5 Gene

Sources for NME5 Gene