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Aliases for NME5 Gene

Aliases for NME5 Gene

  • NME/NM23 Family Member 5 2 3 5
  • Non-Metastatic Cells 5, Protein Expressed In (Nucleoside-Diphosphate Kinase) 2 3
  • Inhibitor Of P53-Induced Apoptosis-Beta 3 4
  • Testis-Specific Nm23 Homolog 3 4
  • NDP Kinase Homolog 5 3 4
  • IPIA-Beta 3 4
  • NDK-H 5 3 4
  • NM23-H5 3 4
  • Non-Metastatic Cells 5 Protein Expressed In 3
  • Radial Spoke 23 Homolog (Chlamydomonas) 2
  • Nucleoside Diphosphate Kinase Homolog 5 3
  • Radial Spoke 23 Homolog 3
  • NM23H5 3
  • RSPH23 3

External Ids for NME5 Gene

Previous GeneCards Identifiers for NME5 Gene

  • GC05M137326
  • GC05M138126
  • GC05M137481
  • GC05M137527
  • GC05M137478
  • GC05M137451
  • GC05M132641

Summaries for NME5 Gene

GeneCards Summary for NME5 Gene

NME5 (NME/NM23 Family Member 5) is a Protein Coding gene. Diseases associated with NME5 include Muscular Dystrophy, Rigid Spine, 1. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and purine nucleotides de novo biosynthesis. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME5 Gene

  • Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME5 Gene

Genomics for NME5 Gene

Regulatory Elements for NME5 Gene

Enhancers for NME5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G137855 1.3 Ensembl ENCODE dbSUPER 14 +281.9 281882 3.5 RING1 PKNOX1 FOXA2 GATA3 CTBP1 FOSL2 RELB FOS IKZF2 CREM NME5 PKD2L2 CDC23 RNU6-1148P GC05M137818 NPY6R
GH05G138335 1.4 ENCODE dbSUPER 12.1 -198.1 -198098 5.0 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF143 SP3 NFYC HNRNPA0 CDC23 KDM3B RPL7P19 NME5 SPOCK1 LRRTM2 FAM13B REEP2 CDC25C
GH05G138035 1.2 Ensembl ENCODE 10.9 +103.3 103346 1.0 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF121 ZNF143 DEK RNU6-1148P WNT8A NME5 RNU6-888P LOC100130172 ENSG00000250260
GH05G138139 0.7 ENCODE 18.1 +0.0 17 0.2 SCRT1 MXI1 RFX1 MAX ZNF407 SIN3A REST ZNF398 BMI1 EP300 NME5 GC05M138124 RNU6-888P
GH05G138027 1.1 ENCODE 11.2 +108.1 108145 6.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 RNU6-1148P NME5 WNT8A RNU6-888P LOC100130172 MYOT LOC101928005 FAM13B GC05P137995
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NME5 on UCSC Golden Path with GeneCards custom track

Promoters for NME5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187460 142 1000 SCRT1 MXI1 RFX1 MAX SIN3A ZNF407 REST ZNF398 BMI1 EP300

Genomic Location for NME5 Gene

Chromosome:
5
Start:
138,115,172 bp from pter
End:
138,139,443 bp from pter
Size:
24,272 bases
Orientation:
Minus strand

Genomic View for NME5 Gene

Genes around NME5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME5 Gene

Proteins for NME5 Gene

  • Protein details for NME5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56597-NDK5_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase homolog 5
    Protein Accession:
    P56597
    Secondary Accessions:
    • B2R5G7

    Protein attributes for NME5 Gene

    Size:
    212 amino acids
    Molecular mass:
    24236 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NME5 Gene

Post-translational modifications for NME5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NME5 Gene

No data available for DME Specific Peptides for NME5 Gene

Domains & Families for NME5 Gene

Gene Families for NME5 Gene

Suggested Antigen Peptide Sequences for NME5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56597

UniProtKB/Swiss-Prot:

NDK5_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME5: view

Function for NME5 Gene

Molecular function for NME5 Gene

GENATLAS Biochemistry:
non-metastatic cells 5,protein,with a nm23 nucleoside diphosphate kinase gene family,specifically expressed in testis germinal cells,expressed in germ cell,kidney,ovary,parathyroid,testis,uterus,involved in the phosphorylation of nucleoside diphosphates and putatively in spermatogenesis
UniProtKB/Swiss-Prot Function:
Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).

Gene Ontology (GO) - Molecular Function for NME5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity TAS,IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with NME5: view
genes like me logo Genes that share phenotypes with NME5: view

Animal Models for NME5 Gene

MGI Knock Outs for NME5:

Animal Model Products

  • Taconic Biosciences Mouse Models for NME5

miRNA for NME5 Gene

miRTarBase miRNAs that target NME5

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NME5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NME5 Gene

Localization for NME5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NME5 gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for NME5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0036126 sperm flagellum IEA --
genes like me logo Genes that share ontologies with NME5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NME5 Gene

Pathways & Interactions for NME5 Gene

genes like me logo Genes that share pathways with NME5: view

Gene Ontology (GO) - Biological Process for NME5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement IEA --
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
genes like me logo Genes that share ontologies with NME5: view

No data available for SIGNOR curated interactions for NME5 Gene

Drugs & Compounds for NME5 Gene

(10) Drugs for NME5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
dctp Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0

(12) Additional Compounds for NME5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxy-Inosine 5'-(tetrahydrogen triphosphate)
  • 2'-Deoxyinosine-5'-triphosphate
  • 2'-Ditp
  • Deoxyinosine 5'-triphosphate
  • Deoxyinosine triphosphate
16595-02-1
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
1173-82-6
genes like me logo Genes that share compounds with NME5: view

Transcripts for NME5 Gene

Unigene Clusters for NME5 Gene

NME/NM23 family member 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NME5

Alternative Splicing Database (ASD) splice patterns (SP) for NME5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - -
SP3:

Relevant External Links for NME5 Gene

GeneLoc Exon Structure for
NME5
ECgene alternative splicing isoforms for
NME5

Expression for NME5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NME5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NME5 Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for NME5 Gene

This gene is overexpressed in Plasma (57.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NME5 Gene



Protein tissue co-expression partners for NME5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NME5 Gene:

NME5

SOURCE GeneReport for Unigene cluster for NME5 Gene:

Hs.730856

mRNA Expression by UniProt/SwissProt for NME5 Gene:

P56597-NDK5_HUMAN
Tissue specificity: Specifically expressed in testis germinal cells.

Evidence on tissue expression from TISSUES for NME5 Gene

  • Nervous system(4.7)
  • Gall bladder(4.2)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with NME5: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NME5 Gene

Orthologs for NME5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NME5 34 35
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia NME5 34 35
  • 91.55 (n)
dog
(Canis familiaris)
Mammalia NME5 34
  • 90.68 (n)
rat
(Rattus norvegicus)
Mammalia Nme5 34
  • 84.04 (n)
mouse
(Mus musculus)
Mammalia Nme5 34 16 35
  • 83.57 (n)
oppossum
(Monodelphis domestica)
Mammalia NME5 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NME5 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NME5 34 35
  • 71.45 (n)
lizard
(Anolis carolinensis)
Reptilia NME5 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nme5 34
  • 72.04 (n)
Str.14959 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.17997 34
zebrafish
(Danio rerio)
Actinopterygii nme5 34 35
  • 65.05 (n)
Dr.14439 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5032 34
fruit fly
(Drosophila melanogaster)
Insecta nmdyn-D6 35
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G17410 34
  • 49.65 (n)
rice
(Oryza sativa)
Liliopsida Os02g0565100 34
  • 49.25 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6539 34
Species where no ortholog for NME5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NME5 Gene

ENSEMBL:
Gene Tree for NME5 (if available)
TreeFam:
Gene Tree for NME5 (if available)

Paralogs for NME5 Gene

Paralogs for NME5 Gene

(3) SIMAP similar genes for NME5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NME5: view

Variants for NME5 Gene

Sequence variations from dbSNP and Humsavar for NME5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000036649 -- 138,138,527(+) ATACT(C/T)AGAAG intron-variant
rs1000195052 -- 138,117,154(+) AAGTG(A/C)GCCGA intron-variant
rs1000371711 -- 138,116,933(+) AAGAG(G/T)CCAGT intron-variant
rs1000507801 -- 138,130,295(+) TGTGC(A/G)CCTGT intron-variant
rs1000609778 -- 138,119,771(+) CCTGC(C/T)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NME5 Gene

Variant ID Type Subtype PubMed ID
esv3575884 CNV gain 25503493
esv3606913 CNV gain 21293372
nsv1114734 CNV deletion 24896259

Variation tolerance for NME5 Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NME5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NME5 Gene

Disorders for NME5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NME5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
muscular dystrophy, rigid spine, 1
  • rigid spine muscular dystrophy 1
- elite association - COSMIC cancer census association via MalaCards
Search NME5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NME5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NME5
genes like me logo Genes that share disorders with NME5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NME5 Gene

Publications for NME5 Gene

  1. A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells. (PMID: 9742940) Munier A. … Lacombe M.-L. (FEBS Lett. 1998) 2 3 4 22 64
  2. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T. … Bobe J. (BMC Evol. Biol. 2009) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for NME5 Gene

  • Addgene plasmids for NME5

Sources for NME5 Gene

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