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NME5 Gene

protein-coding   GIFtS: 52
GCID: GC05M137451

NME/NM23 Family Member 5

(Previous names: non-metastatic cells 5, protein expressed in (nucleoside-diphosphate...)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NME/NM23 Family Member 51 2     NM23H52 5
Non-Metastatic Cells 5, Protein Expressed In (Nucleoside-Diphosphate
Kinase)1 2
     Radial Spoke 23 Homolog (Chlamydomonas)1
Inhibitor Of P53-Induced Apoptosis-Beta2 3     NM23-H52
Testis-Specific Nm23 Homolog2 3     RSPH232
IPIA-beta2 3     Nucleoside Diphosphate Kinase Homolog 52
NDK-H 52 3     Radial Spoke 23 Homolog2
NDP Kinase Homolog 52 3     nm23-H53

External Ids:    HGNC: 78531   Entrez Gene: 83822   Ensembl: ENSG000001129817   OMIM: 6035755   UniProtKB: P565973   

Export aliases for NME5 gene to outside databases

Previous GC identifers: GC05M137326 GC05M138126 GC05M137481 GC05M137527 GC05M137478 GC05M132641


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NME5 Gene:
NME5 (NME/NM23 family member 5) is a protein-coding gene. Diseases associated with NME5 include pneumonia, and pancreatic cancer. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME2.

UniProtKB/Swiss-Prot: NDK5_HUMAN, P56597
Function: Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the
cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing
the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NME5 gene promoter:
         Max1   AML1a   Pax-2   IRF-1   Pax-2a   FOXL1   C/EBPalpha   AREB6   Pax-2b   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNME5 promoter sequence
   Search Chromatin IP Primers for NME5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31.2

NME5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME5 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M137451:  view genomic region     (about GC identifiers)

Start:
137,450,861 bp from pter      End:
137,475,132 bp from pter
Size:
24,272 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NDK5_HUMAN, P56597 (See protein sequence)
Recommended Name: Nucleoside diphosphate kinase homolog 5  
Size: 212 amino acids; 24236 Da
Secondary accessions: B2R5G7

Explore the universe of human proteins at neXtProt for NME5: NX_P56597

Explore proteomics data for NME5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NME5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003542.1  
    ENSEMBL proteins: 
     ENSP00000265191  

    NME5 Human Recombinant Protein Products:

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    OriGene Purified Protein for NME5
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    OriGene MassSpec for NME5
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    GenScript Custom Purified and Recombinant Proteins Services for NME5
    Novus Biologicals NME5 Proteins
    Novus Biologicals NME5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NME5

    NME5 Antibody Products:

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    Novus Biologicals NME5 Antibodies
    Abcam antibodies for NME5
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    ThermoFisher Antibodies for NME5
    LSBio Antibodies in human, mouse, rat for NME5

    NME5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NME5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NME5
    Cloud-Clone Corp. CLIAs for NME5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR007858 Dpy-30_motif
     IPR001564 Nucleoside_diP_kinase
     IPR012410 NDK_H5

    Graphical View of Domain Structure for InterPro Entry P56597

    ProtoNet protein and cluster: P56597

    2 Blocks protein domains:
    IPB001564 Nucleoside diphosphate kinase
    IPB007858 Dpy-30


    UniProtKB/Swiss-Prot: NDK5_HUMAN, P56597
    Similarity: Belongs to the NDK family


    NME5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDK5_HUMAN, P56597
    Function: Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the
    cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing
    the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity)

         Genatlas biochemistry entry for NME5:
    non-metastatic cells 5,protein,with a nm23 nucleoside diphosphate kinase gene family,specifically expressed in
    testis germinal cells,expressed in germ cell,kidney,ovary,parathyroid,testis,uterus,involved in the
    phosphorylation of nucleoside diphosphates and putatively in spermatogenesis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004550nucleoside diphosphate kinase activity IEA--
    GO:0005524ATP binding IEA--
         
    NME5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NME5:
     Increased cell death in HCT116 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nme5):
     cardiovascular system  craniofacial  growth/size/body  nervous system  reproductive system 
     respiratory system  skeleton 

    NME5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nme5tm1Lex for NME5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NME5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NME5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NME5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NME5

    miRNA
    Products:
        
    miRTarBase miRNAs that target NME5:
    hsa-mir-26b-5p (MIRT029961), hsa-mir-148b-3p (MIRT019446)

    Block miRNA regulation of human, mouse, rat NME5 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate NME5:
    hsa-miR-433 hsa-miR-3658 hsa-miR-374b hsa-miR-375 hsa-miR-2116 hsa-miR-374a hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidNME5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NME5
    Predesigned siRNA for gene silencing in human, mouse, rat NME5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NME5

    Clone
    Products:
         
    OriGene clones in human, mouse for NME5 (see all 8)
    OriGene ORF clones in mouse, rat for NME5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NME5 (NM_003551)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NME5
    Browse ESI BIO Cell Lines and PureStem Progenitors for NME5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0036126sperm flagellum IEA--

    NME5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NME5 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    purine deoxyribonucleosides salvage0.00
    Pyrimidine metabolism0.38
    2superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
    adenosine deoxyribonucleotides de novo biosynthesis0.00
    guanosine deoxyribonucleotides de novo biosynthesis0.52
    pyrimidine deoxyribonucleotides de novo biosynthesis0.00
    superpathway of pyrimidine deoxyribonucleoside salvage0.46
    UTP and CTP de novo biosynthesis0.00
    CMP phosphorylation0.00
    superpathway of pyrimidine ribonucleotides de novo biosynthesis0.00
    3purine nucleotide salvage
    purine nucleotide salvage0.78
    guanosine nucleotides de novo biosynthesis0.00
    purine nucleotides de novo biosynthesis0.78
    guanosine ribonucleotides de novo biosynthesis0.00
    4Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for NME5 (see all 15)
        purine nucleotides de novo biosynthesis
    superpathway of pyrimidine ribonucleotides de novo biosynthesis
    purine deoxyribonucleosides salvage
    guanosine nucleotides de novo biosynthesis
    purine nucleotide salvage


    3 Kegg Pathways  (Kegg details for NME5):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways


    NME5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NME5: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NME5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NME5 (P565972, 3 ENSP000002651914) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYDC1Q8WWB32, 3, ENSP000003612764MINT-66095 I2D: score=4 STRING: ENSP00000361276
    DYDC2Q96IM93, ENSP000002560394I2D: score=4 STRING: ENSP00000256039
    RELAQ042062, ENSP000003842734MINT-8307338 STRING: ENSP00000384273
    NFS1Q9Y6973I2D: score=1 
    ADCY8ENSP000002863554STRING: ENSP00000286355
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003351epithelial cilium movement IEA--
    GO:0006165nucleoside diphosphate phosphorylation ----
    GO:0006183GTP biosynthetic process IEA--
    GO:0006228UTP biosynthetic process IEA--
    GO:0006241CTP biosynthetic process IEA--

    NME5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NME5 (NDK5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NME5 gene: 
    NM_003551.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265191(uc003lce.3) ENST00000506657 ENST00000514481 ENST00000508252
    ENST00000511353 ENST00000512954
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NME5 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate NME5:
    hsa-miR-433 hsa-miR-3658 hsa-miR-374b hsa-miR-375 hsa-miR-2116 hsa-miR-374a hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidNME5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NME5
    Predesigned siRNA for gene silencing in human, mouse, rat NME5
    Clone
    Products:
         
    OriGene clones in human, mouse for NME5 (see all 8)
    OriGene ORF clones in mouse, rat for NME5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NME5 (NM_003551)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NME5
    OriGene qSTAR qPCR primer pairs in human, mouse for NME5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NME5
      QuantiTect SYBR Green Assays in human, mouse, rat NME5
      QuantiFast Probe-based Assays in human, mouse, rat NME5

    Selected AceView cDNA sequences (see all 69):

    AA400452 AA393878 NM_003551 BX100052 W39101 AA453579 AL043779 AA477853 
    BU677743 AI796075 AA292811 BC026182 AA400478 AL043778 AA431789 BM979998 
    AA434444 AF067724 AI367603 AI364955 BM968993 AA477747 AI184543 AI017290 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NME5    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
    SP1:                                -                                 
    SP2:              -                 -                                 
    SP3:                                                                  


    ECgene alternative splicing isoforms for NME5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NME5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCAGATAT
    NME5 Expression
    About this image


    NME5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Neural Tube (Nervous System)
             Floor plate-like cells
    NME5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NME5 Protein Expression

    UniProtKB/Swiss-Prot: NDK5_HUMAN, P56597
    Tissue specificity: Specifically expressed in testis germinal cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NME5: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NME5
    OriGene qSTAR qPCR primer pairs in human, mouse for NME5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NME5
    QuantiTect SYBR Green Assays in human, mouse, rat NME5
    QuantiFast Probe-based Assays in human, mouse, rat NME5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NME5 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nme51 , 5 non-metastatic cells 5, protein expressed in (nucleoside-diphosphate more5
    NME/NM23 family member 51
    83.57(n)1
    86.26(a)1
      18 (18.69 cM)5
    755331  NM_080637.31  NP_542368.21 
     345626345 
    chicken
    (Gallus gallus)
    Aves NME51 non-metastatic cells 5, protein expressed in (nucleoside-diphosphate more 71.45(n)
    75.12(a)
      426732  NM_001257371.1  NP_001244300.1 
    lizard
    (Anolis carolinensis)
    Reptilia NME56
    NME/NM23 family member 5
    79(a)
    1 ↔ 1
    GL344505.1(1964-11758)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.179972 Xenopus laevis transcribed sequence with moderate similarity more 73.57(n)    BX851959.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.144392 Transcribed sequence with weak similarity to protein more 75.68(n)    BI672891.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nmdyn-D66
    nmdyn-D6
    36(a)
    1 → many
    X(14477710-14478649)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G174101 AT1G17410 49.65(n)
    43.36(a)
      838313  NM_101602.3  NP_173184.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g05651001 Os02g0565100 49.25(n)
    46.27(a)
      4329701  NM_001053699.1  NP_001047164.1 


    ENSEMBL Gene Tree for NME5 (if available)
    TreeFam Gene Tree for NME5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NME5 gene
    NME22  NME12  NME32  NME82  NME42  NME72  NME1-NME22  NME62  
    NME92  
    3 SIMAP similar genes for NME5 using alignment to 1 protein entry:     NDK5_HUMAN:
    NME7    NME6    NME8

    NME5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NME5 (see all 397)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867296931,2
    --137450372(+) TCAGCC/TAACAA 1 -- int10--------
    rs2010636901,2
    --137450421(+) TCTCT-/CTTTTT 1 -- int10--------
    rs131856441,2
    C,F,H--137450422(+) tctctT/Cttttt 1 -- int116Minor allele frequency- C:0.41NS EA NA WA CSA 1980
    rs1812210571,2
    --137450878(+) TCTATC/TTTTTA 1 -- ut310--------
    rs623834931,2
    C--137450981(+) TATGGA/GCTACA 1 -- ut310--------
    rs1863641341,2
    --137451050(+) ATATAA/GGATAT 1 -- ut310--------
    rs1426382701,2
    C--137451158(+) CTAGTA/GTTACA 1 -- ut310--------
    rs1901859571,2
    --137451206(+) TTAATC/GTTATC 1 -- ut310--------
    rs1445240551,2
    C--137451417(+) TTTGTT/CAGGAT 2 /N /D mis11Minor allele frequency- C:0.00NA 4414
    rs1820498711,2
    C--137451437(+) GCAGCC/TAATCA 2 * W stg10--------

    HapMap Linkage Disequilibrium report for NME5 (137450861 - 137475132 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NME5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NME5
    DNA2.0 Custom Variant and Variant Library Synthesis for NME5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603575    OMIM disorders: --

    4 diseases for NME5:    
    About MalaCards
    pneumonia    pancreatic cancer    pancreatitis    endotheliitis


    NME5 for disorders           About GeneDecksing


    Export disorders for NME5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NME5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NME5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells. (PubMed id 9742940)1, 2, 3, 9 Munier A.... Lacombe M.-L. (FEBS Lett. 1998)
    2. Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)1, 3 Desvignes T....Bobe J. (BMC Evol. Biol. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Transactivation of the human NME5 gene by Sp1 in pancreatic cancer cells. (PubMed id 22564704)1 Li F....Zhang L. (Gene 2012)
    5. Shifted Transversal Design smart-pooling for high coverage interactome mapping. (PubMed id 19447967)1 Xin X....Thierry-Mieg N. (Genome Res. 2009)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Nm23/NDP kinases in human male germ cells: role in spermiogenesis and sperm motility? (PubMed id 14499630)1 Munier A....Lacombe M.L. (Exp. Cell Res. 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8382 HGNC: 7853 AceView: NME5 Ensembl:ENSG00000112981 euGenes: HUgn8382
    ECgene: NME5 Kegg: 8382 H-InvDB: NME5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NME5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NME5 gene:
    Search GeneIP for patents involving NME5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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