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NME4 Gene

protein-coding   GIFtS: 67
GCID: GC16P000446

NME/NM23 Nucleoside Diphosphate Kinase 4

(Previous names: non-metastatic cells 4, protein expressed in)
  See NME4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NME/NM23 Nucleoside Diphosphate Kinase 41 2     EC 2.7.4.63 8
Non-Metastatic Cells 4, Protein Expressed In1 2     NDPK-D2
Nucleoside Diphosphate Kinase D2 3     NM23H42
NDK2 3     NDP Kinase D2
NDPKD2 3     Nucleoside Diphosphate Kinase, Mitochondrial2
NDP Kinase, Mitochondrial2 3     NM23D3
nm23-H42 3     

External Ids:    HGNC: 78521   Entrez Gene: 48332   Ensembl: ENSG000001032027   OMIM: 6018185   UniProtKB: O007463   

Export aliases for NME4 gene to outside databases

Previous GC identifers: GC16P000466 GC16P000387 GC16P000368


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NME4 Gene:
The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of
gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and
diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 (PubMed
9099850)).(supplied by OMIM, May 2008)

GeneCards Summary for NME4 Gene:
NME4 (NME/NM23 nucleoside diphosphate kinase 4) is a protein-coding gene. Diseases associated with NME4 include fatal infantile lactic acidosis, and cystic fibrosis. An important paralog of this gene is NME2.

UniProtKB/Swiss-Prot: NDKM_HUMAN, O00746
Function: Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity)

Gene Wiki entry for NME4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NME4 gene promoter:
         GR   NRSF form 1   GR-beta   NRSF form 2   Tal-1beta   AREB6   PPAR-alpha   S8   GR-alpha   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNME4 promoter sequence
   Search Chromatin IP Primers for NME4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

NME4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000446:  view genomic region     (about GC identifiers)

Start:
446,725 bp from pter      End:
460,367 bp from pter
Size:
13,643 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NDKM_HUMAN, O00746 (See protein sequence)
Recommended Name: Nucleoside diphosphate kinase, mitochondrial precursor  
Size: 187 amino acids; 20659 Da
Cofactor: Magnesium (By similarity)
Subunit: Homohexamer. Interacts with CAPN8 (By similarity)
1 PDB 3D structure from and Proteopedia for NME4:
1EHW (3D)    
Secondary accessions: Q5U0M9

Explore the universe of human proteins at neXtProt for NME4: NX_O00746

Explore proteomics data for NME4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NME4 (O00746) (see all 5)
     PGTIRGD  KPDGVQR  AAPGTIR  SGPVVAMV 


    See NME4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001273362.1  NP_001273364.1  NP_001273365.1  NP_001273367.1  NP_001273368.1  NP_001273369.1  NP_005000.1  

    ENSEMBL proteins: 
     ENSP00000380834   ENSP00000406317   ENSP00000412039   ENSP00000395605   ENSP00000372398  
     ENSP00000219479   ENSP00000405925   ENSP00000389048  
    Reactome Protein details: O00746

    NME4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for NME4
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    OriGene MassSpec for NME4
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    GenScript Custom Purified and Recombinant Proteins Services for NME4
    Novus Biologicals NME4 Proteins
    Novus Biologicals NME4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NME4
    Cloud-Clone Corp. Proteins for NME4

     
    Search eBioscience for Proteins for NME4 

    NME4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    NME4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for NME4
    Cloud-Clone Corp. CLIAs for NME4
    Search eBioscience for ELISAs for NME4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR023005 Nucleoside_diP_kinase_AS
     IPR001564 Nucleoside_diP_kinase

    Graphical View of Domain Structure for InterPro Entry O00746

    ProtoNet protein and cluster: O00746

    1 Blocks protein domain: IPB001564 Nucleoside diphosphate kinase

    UniProtKB/Swiss-Prot: NDKM_HUMAN, O00746
    Similarity: Belongs to the NDK family


    Find genes that share domains with NME4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDKM_HUMAN, O00746
    Function: Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity)
    Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

         Genatlas biochemistry entry for NME4:
    non-metastatic cells 4,protein,nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of
    nucleoside diphosphates and putatively involved int intramitochondrial GTP metabolism

         Enzyme Number (IUBMB): EC 2.7.4.61 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004550nucleoside diphosphate kinase activity EXP--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0032403protein complex binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with NME4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NME4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NME4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NME4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NME4

    miRNA
    Products:
        
    miRTarBase miRNAs that target NME4:
    hsa-mir-124-3p (MIRT002663), hsa-mir-484 (MIRT042220), hsa-let-7e-5p (MIRT051476), hsa-mir-193b-3p (MIRT041585), hsa-let-7c-5p (MIRT051761), hsa-mir-769-3p (MIRT039059), hsa-let-7a-5p (MIRT052558), hsa-mir-378a-3p (MIRT043937), hsa-let-7b-5p (MIRT052182)

    Block miRNA regulation of human, mouse, rat NME4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NME4 (see all 16):
    hsa-miR-98 hsa-let-7d hsa-miR-486-3p hsa-let-7c hsa-let-7i hsa-miR-196a hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidNME4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NME4
    Predesigned siRNA for gene silencing in human, mouse, rat NME4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NME4

    Clone
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    OriGene ORF clones in mouse, rat for NME4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NME4 (NM_005009)
    Sino Biological Human cDNA Clone for NME4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME4
    Addgene plasmids for NME4 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NME4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDKM_HUMAN, O00746: Mitochondrion intermembrane space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    chloroplast2
    cytoskeleton2
    cytosol2
    plasma membrane2
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS9099850
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005758mitochondrial intermembrane space IEA--

    Find genes that share ontologies with NME4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NME4 About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    Pyrimidine metabolism0.38
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Purine metabolism (REACTOME)
    Metabolism of nucleotides0.42
    Synthesis and interconversion of nucleotide di- and triphosphates0.00


    Find genes that share SuperPaths with NME4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NME4
        ATP/ITP metabolism


    1 Reactome Pathway for NME4
        Synthesis and interconversion of nucleotide di- and triphosphates


    3 Kegg Pathways  (Kegg details for NME4):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Array including NME4: 
              Tumor Metastasis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NME4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NME4 (O007461, 2, 3 ENSP000002194794) via UniProtKB, MINT, STRING, and/or I2D (see all 355)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME1P155312, 3, ENSP000000130344MINT-66576 I2D: score=5 STRING: ENSP00000013034
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    TRIP13Q156452, 3, ENSP000001663454MINT-66831 I2D: score=5 STRING: ENSP00000166345
    TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
    PNPT1Q8TCS82, ENSP000003939534MINT-8079030 STRING: ENSP00000393953
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006165nucleoside diphosphate phosphorylation ----
    GO:0006183GTP biosynthetic process IEA--
    GO:0006228UTP biosynthetic process IEA--
    GO:0006241CTP biosynthetic process IEA--
    GO:0009116nucleoside metabolic process TAS9099850

    Find genes that share ontologies with NME4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NME4 (NDKM)

    Selected HMDB Compounds for NME4 (see all 21)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2'-Deoxyinosine triphosphate2'-Deoxyinosine-5'-triphosphate (see all 6)16595-02-1--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CDPCDP (see all 3)63-38-7--
    Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--
    Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--

    8 Novoseek inferred chemical compound relationships for NME4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 57.7 13 1325460 (5), 9402029 (2), 15280044 (1), 9988471 (1)
    alginate 54.4 4 7730279 (1), 10671455 (1), 9988471 (1)
    gdp 44.5 5 1325460 (4)
    atp 44.3 1 10496900 (1)
    adp 34.4 1 18635542 (1)
    adenylate 26.1 3 19409873 (1), 10496900 (1), 10931297 (1)
    creatinine 14.1 1 19409873 (1)
    glycogen 13.4 1 8075120 (1)



    Find genes that share compounds with NME4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NME4 gene (7 alternative transcripts): 
    NM_001286433.1  NM_001286435.1  NM_001286436.1  NM_001286438.1  NM_001286439.1  NM_001286440.1  NM_005009.2  

    Unigene Cluster for NME4:

    NME/NM23 nucleoside diphosphate kinase 4
    Hs.9235  [show with all ESTs]
    Unigene Representative Sequence: BM909196
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397722(uc021szp.1) ENST00000454619 ENST00000448828 ENST00000444498
    ENST00000460297 ENST00000382940 ENST00000219479(uc002cgz.3) ENST00000433358
    ENST00000450036 ENST00000468031
    miRNA
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    Block miRNA regulation of human, mouse, rat NME4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NME4 (see all 16):
    hsa-miR-98 hsa-let-7d hsa-miR-486-3p hsa-let-7c hsa-let-7i hsa-miR-196a hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidNME4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NME4
    Clone
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    OriGene ORF clones in mouse, rat for NME4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NME4 (NM_005009)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME4
    Addgene plasmids for NME4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NME4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NME4
      QuantiTect SYBR Green Assays in human, mouse, rat NME4
      QuantiFast Probe-based Assays in human, mouse, rat NME4

    Additional mRNA sequence: 

    AF086133.1 BC004880.2 BC017067.1 BT019438.1 DQ655948.2 Y07604.1 

    23 DOTS entries:

    DT.117376  DT.100034045  DT.100863219  DT.100059396  DT.91748358  DT.100650869  DT.120676537  DT.95168085 
    DT.97856962  DT.91956775  DT.100059398  DT.91984944  DT.95168097  DT.97824737  DT.101960127  DT.75184922 
    DT.91938512  DT.100865547  DT.120676510  DT.40107648  DT.40261948  DT.86840519  DT.92380828 

    Selected AceView cDNA sequences (see all 477):

    NM_020664 BQ650649 AI146511 AK055839 CR611773 AI871437 AF086133 BQ773593 
    BG770530 BP374800 AA304771 BU633075 AK128012 BX096361 CB138400 AW137674 
    AI672942 BM013916 AA338136 BM750323 Z45138 AI754704 BQ229642 AK094439 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NME4 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                              -     -     -                                                                     
    SP2:                                                                                                                    -                           
    SP3:                                                                                                        -                                       
    SP4:                                                        -     -     -                                                                           
    SP5:                                      -     -     -     -     -                                         -                                       


    ECgene alternative splicing isoforms for NME4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NME4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGTACAC
    NME4 Expression
    About this image


    NME4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Endothelial Cells Blood Brain Barrier
     
     Prostate (Endocrine System)
    NME4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NME4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.9235

    UniProtKB/Swiss-Prot: NDKM_HUMAN, O00746
    Tissue specificity: Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and
    skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including NME4: 
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NME4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NME4
    QuantiTect SYBR Green Assays in human, mouse, rat NME4
    QuantiFast Probe-based Assays in human, mouse, rat NME4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NME4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nme41 , 5 non-metastatic cells 4, protein expressed in5
    NME/NM23 nucleoside diphosphate kinase 41
    82.16(n)1
    83.78(a)1
      17 (13.06 cM)5
    565201  NM_019731.11  NP_062705.11 
     260917345 
    chicken
    (Gallus gallus)
    Aves NME46
    NME/NM23 nucleoside diphosphate kinase 4
    56(a)
    1 ↔ 1
    14(13001720-13003063)
    lizard
    (Anolis carolinensis)
    Reptilia NME46
    NME/NM23 nucleoside diphosphate kinase 4
    61(a)
    1 ↔ 1
    GL343518.1(26764-32476)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98942 Xenopus laevis transcribed sequence with weak similarity more 74.65(n)    BJ029119.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc564822 similar to non-metastatic cells 4, protein expressed more 75.11(n)   394170  BC049030.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta awd6
    abnormal wing discs
    47(a)
    1 → many
    3R(27570894-27571706)
    worm
    (Caenorhabditis elegans)
    Secernentea ndk-16
    Protein NDK-1 (ndk-1) mRNA, complete cds
    52(a)
    1 → many
    I(10553112-10553913) WBGene00009119
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YNK16
    Nucleoside diphosphate kinase, catalyzes the trans...
    49(a)
    1 → many
    XI(314812-315273) YKL067W


    ENSEMBL Gene Tree for NME4 (if available)
    TreeFam Gene Tree for NME4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NME4 gene
    NME22  NME12  NME32  NME82  NME72  NME1-NME22  NME62  NME92  
    NME52  
    8 SIMAP similar genes for NME4 using alignment to 7 protein entries:     NDKM_HUMAN (see all proteins):
    NME1-NME2    NME3    NME2    c371H6.2    NME1    NME2P1
    NME6    NME7

    Find genes that share paralogs with NME4           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for NME4
    PGOHUM00000237341 PGOHUM00000250911 PGOHUM00000236422


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NME4 (see all 164)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871009221,2
    --445335(+) CTCTAA/CAAAGA 1 -- us2k10--------
    rs1919240661,2
    --445347(+) AGAAAC/GTCACT 1 -- us2k10--------
    rs43995361,2
    C,F,H--445418(+) aggcaC/Ttcaga 1 -- us2k112Minor allele frequency- T:0.41NA WA CSA EA 374
    rs773229761,2
    C,F--445450(+) CGTCTC/GTATTC 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1490410931,2
    C--445483(+) TTTTCTTT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1995856211,2
    --445486(+) CTTTT-/CTTTTT 1 -- us2k10--------
    rs1408313961,2
    --445550(+) GCTCTC/TGGCTC 1 -- us2k10--------
    rs786551691,2
    C--445643(+) TGTCCA/CGCTAA 1 -- us2k10--------
    rs1501665161,2
    --445658(+) TGTATA/TTTTAG 1 -- us2k10--------
    rs605383931,2
    C,F--445734(+) CTCGGC/GCTCCC 1 -- us2k17Minor allele frequency- G:0.25NA WA CSA 12

    HapMap Linkage Disequilibrium report for NME4 (446725 - 460367 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NME4 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv904713CNV Loss21882294
    nsv457303CNV Loss19166990
    nsv904707CNV Loss21882294
    dgv2473n71CNV Loss21882294
    nsv904711CNV Loss21882294
    dgv2474n71CNV Loss21882294
    nsv904714CNV Loss21882294
    dgv2469n71CNV Loss21882294
    dgv32n68CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NME4
    DNA2.0 Custom Variant and Variant Library Synthesis for NME4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601818    OMIM disorders: --

    2 diseases for NME4:    
    About MalaCards
    fatal infantile lactic acidosis    cystic fibrosis


    Find genes that share disorders with NME4           About GenesLikeMe

    4 Novoseek inferred disease relationships for NME4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystic fibrosis 43.4 1 10496900 (1)
    metastasis 14.7 5 1325460 (1), 18621712 (1), 12874011 (1), 16757312 (1)
    tumors 0 5 11343655 (2), 1325460 (1), 18621712 (1)
    tuberculosis 0 2 9402029 (1), 15280044 (1)

    Genetic Association Database (GAD): NME4
    Human Genome Epidemiology (HuGE) Navigator: NME4 (1 document)

    Export disorders for NME4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NME4 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with NME4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13. (PubMed id 9099850)1, 2, 3, 9 Milon L.... Lacombe M.-L. (Hum. Genet. 1997)
    2. The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase. (PubMed id 10799505)1, 2, 9 Milon L.... Lacombe M.-L. (J. Biol. Chem. 2000)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)1, 3 Desvignes T....Bobe J. (BMC Evol. Biol. 2009)
    5. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    8. Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase. (PubMed id 11831846)1, 9 Kowluru A....Chen H.Q. (Arch. Biochem. Biophys. 2002)
    9. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    10. Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network. (PubMed id 23446634)1 Chen Z....Reiner A.P. (Hum. Mol. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4833 HGNC: 7852 AceView: NME4andDECR2 Ensembl:ENSG00000103202 euGenes: HUgn4833
    ECgene: NME4 Kegg: 4833 H-InvDB: NME4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NME4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NME4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NME4 gene:
    Search GeneIP for patents involving NME4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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