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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NME4 Gene

protein-coding GIFtS: 66
GCID: GC16P000446

NME/NM23 nucleoside diphosphate kinase 4

(Previous names: non-metastatic cells 4, protein expressed in )

Explore 14 diseases affiliated with
NME4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NME/NM23 Nucleoside Diphosphate Kinase 4¹ ²		NDP Kinase, Mitochondrial² ³
Nm23-H4¹		EC 2.7.4.6³ ⁸
NM23H4¹ ²		NDPK-D²
Non-Metastatic Cells 4, Protein Expressed In¹ ²		NDP Kinase D²
Nucleoside Diphosphate Kinase D² ³		Nucleoside Diphosphate Kinase, Mitochondrial²
NDK² ³		NM23D³
NDPKD² ³

External Ids:	HGNC: 7852¹	Entrez Gene: 4833²	Ensembl: ENSG00000103202⁷	OMIM: 601818⁵	UniProtKB: O00746³

Export aliases for NME4 gene to outside databases

Previous GC identifers: GC16P000466 GC16P000387 GC16P000368

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NME4:

The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of

gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates.

The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 (PubMed 9099850)).(supplied

by OMIM, May 2008)

UniProtKB/Swiss-Prot: NDKM_HUMAN, O00746

Function: Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity)

Gene Wiki entry for NME4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NME4 gene promoter:
GR NRSF form 1 GR-beta NRSF form 2 Tal-1beta AREB6 PPAR-alpha S8 GR-alpha ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NME4 promoter sequence

Search SABiosciences Chromatin IP Primers for NME4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NME4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

NME4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME4 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P000446: view genomic region (about GC identifiers)

Start:	446,725 bp from pter	End:	460,367 bp from pter
Size:	13,643 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NDKM_HUMAN, O00746 (See protein sequence)

Recommended Name: Nucleoside diphosphate kinase, mitochondrial precursor

Size: 187 amino acids; 20659 Da

Cofactor: Magnesium (By similarity)

Subunit: Homohexamer. Interacts with CAPN8 (By similarity)

Subcellular location: Mitochondrion intermembrane space

1 PDB 3D structure from and Proteopedia for NME4:

1EHW (3D)

Secondary accessions: Q5U0M9

Explore the universe of human proteins at neXtProt for NME4: NX_O00746

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00746

4/5 DME Specific Peptides for NME4 (O00746) (see all 5)

PGTIRGD

KPDGVQR

AAPGTIR

SGPVVAMV

NME4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005000.1

ENSEMBL proteins:

ENSP00000380834 ENSP00000406317 ENSP00000412039 ENSP00000395605 ENSP00000219479

ENSP00000372398 ENSP00000405925 ENSP00000389048 ENSP00000405828

Reactome Protein details: O00746
Human Recombinant Protein Products for NME4:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals NME4 Proteins Novus Biologicals NME4 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for NME4
	Uscn Proteins for NME4

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	TAS	9099850
GO:0005743	mitochondrial inner membrane	TAS	--
GO:0005758	mitochondrial intermembrane space	IEA	--

NME4 for ontologies About GeneDecksing

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	Novus Biologicals NME4 Antibodies
	Abcam antibodies for NME4
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	ThermoFisher Antibodies for NME4

Assay Products for NME4:

	Browse Kits and Assays available from EMD Millipore
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NME4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NME4 for domains About GeneDecksing

2 InterPro domains/families:

IPR023005 Nucleoside_diP_kinase_AS

IPR001564 Nucleoside_diP_kinase

Graphical View of Domain Structure for InterPro Entry O00746

ProtoNet protein and cluster: O00746

1 Blocks protein family: IPB001564 Nucleoside diphosphate kinase

UniProtKB/Swiss-Prot: NDKM_HUMAN, O00746

Similarity: Belongs to the NDK family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NDKM_HUMAN, O00746

Function: Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity)

Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

Genatlas biochemistry entry for NME4:

non-metastatic cells 4,protein,nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of

nucleoside diphosphates and putatively involved int intramitochondrial GTP metabolism

Enzyme Number (IUBMB): EC 2.7.4.6¹ ²

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004550	nucleoside diphosphate kinase activity	EXP	--
GO:0005524	ATP binding	IEA	--
GO:0046872	metal ion binding	IEA	--

NME4 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NME4

miRNA Products:		miRTarBase miRNAs that target NME4: hsa-mir-124 (MIRT002663)

		OriGene 3'-UTR Clone: NME4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NME4
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate NME4 (see all 16):
		hsa-miR-98 hsa-let-7d hsa-miR-486-3p hsa-let-7c hsa-let-7i hsa-miR-196a hsa-let-7e hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: NME4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NME4 (see all 7) OriGene shRNA RFP: NME4 OriGene siRNA: NME4
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NME4
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NME4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NME4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NME4 (NM_005009)
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NME4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

pyrimidine ribonucleotides interconversion

	pyrimidine ribonucleotides interconversion	1.00			pyrimidine deoxyribonucleotides de novo biosynthesis I	0.50
	pyrimidine ribonucleotides de novo biosynthesis	0.88			salvage pathways of pyrimidine ribonucleotides	0.45

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Purine metabolism

Purine metabolism

1.00

Pyrimidine metabolism

0.38

ATP/ITP metabolism

ATP/ITP metabolism

1.00

ATP/ITP metabolism

0.98

Synthesis and interconversion of nucleotide di- and triphosphates

Synthesis and interconversion of nucleotide di- and triphosphates

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NME4

ATP/ITP metabolism

1 GeneGo (Thomson Reuters) Pathway for NME4

ATP/ITP metabolism

4 BioSystems Pathways for NME4

	pyrimidine ribonucleotides interconversion
	pyrimidine ribonucleotides de novo biosynthesis
	salvage pathways of pyrimidine ribonucleotides
	pyrimidine deoxyribonucleotides de novo biosynthesis I

3 Reactome Pathways for NME4

	Metabolism of nucleotides
	Synthesis and interconversion of nucleotide di- and triphosphates
	Metabolism

3 Kegg Pathways (Kegg details for NME4):

	Purine metabolism
	Pyrimidine metabolism
	Metabolic pathways

NME4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NME4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/335 Interacting proteins for NME4 (O00746^{1, 2, 3} ENSP00000219479⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 335)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NME1	P15531²^,³, ENSP00000013034⁴	MINT-66576 I2D: score=5 STRING: ENSP00000013034
ICT1	Q14197²^,³, ENSP00000301585⁴	MINT-8079030 I2D: score=1 STRING: ENSP00000301585
TRIP13	Q15645²^,³, ENSP00000166345⁴	MINT-66831 I2D: score=5 STRING: ENSP00000166345
TERF2	Q15554³, ENSP00000254942⁴	I2D: score=1 STRING: ENSP00000254942
PNPT1	Q8TCS8², ENSP00000393953⁴	MINT-8079030 STRING: ENSP00000393953

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006165	nucleoside diphosphate phosphorylation	--	--
GO:0006183	GTP biosynthetic process	IEA	--
GO:0006228	UTP biosynthetic process	IEA	--
GO:0006241	CTP biosynthetic process	IEA	--
GO:0009116	nucleoside metabolic process	TAS	9099850

NME4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NME4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NME4

10/21 HMDB Compounds for NME4 (see all 21) About this table

Compound	Synonyms	CAS #	PubMed Ids
2'-Deoxyinosine triphosphate	2'-Deoxyinosine-5'-triphosphate (see all 6)	16595-02-1	--
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
CDP	CDP (see all 3)	63-38-7	--
Cytidine triphosphate	cytidine 5'-(tetrahydrogen triphosphate) (see all 15)	65-47-4	--
Deoxyuridine triphosphate	2'-Deoxyuridine-5'-triphosphorate (see all 9)	1173-82-6	--
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
IDP	5'-IDP (see all 10)	86-04-4	--
Inosine triphosphate	inosine 5'-(tetrahydrogen triphosphate) (see all 13)	132-06-9	--

8 Novoseek chemical compound relationships for NME4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	57.7	13	1325460 (5), 9402029 (2), 15280044 (1), 9988471 (1)
alginate	54.4	4	7730279 (1), 10671455 (1), 9988471 (1)
gdp	44.5	5	1325460 (4)
atp	44.3	1	10496900 (1)
adp	34.4	1	18635542 (1)
adenylate	26.1	3	19409873 (1), 10496900 (1), 10931297 (1)
creatinine	14.1	1	19409873 (1)
glycogen	13.4	1	8075120 (1)

Search CenterWatch for drugs/clinical trials and news about NME4 / NDKM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NME4 gene:

NM_005009.2

Unigene Cluster for NME4:

NME/NM23 nucleoside diphosphate kinase 4

Hs.9235 [show with all ESTs]

Unigene Representative Sequence: BM909196

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000397722(uc021szp.1) ENST00000454619 ENST00000448828 ENST00000444498

ENST00000460297 ENST00000219479(uc002cgz.3) ENST00000382940 ENST00000433358

ENST00000450036 ENST00000468031 ENST00000426167

miRNA Products:		OriGene 3'-UTR Clone: NME4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NME4
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate NME4 (see all 16):
		hsa-miR-98 hsa-let-7d hsa-miR-486-3p hsa-let-7c hsa-let-7i hsa-miR-196a hsa-let-7e hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: NME4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against NME4

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		GenScript: all cDNA clones in your preferred vector: NME4 (NM_005009)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NME4

Additional cDNA sequence:

AF086133.1 BC004880.2 BC017067.1 BT019438.1 DQ655948.2 Y07604.1

23 DOTS entries:

DT.117376 DT.100034045 DT.100863219 DT.100059396 DT.91748358 DT.100650869 DT.120676537 DT.95168085

DT.97856962 DT.91956775 DT.91984944 DT.100059398 DT.95168097 DT.97824737 DT.101960127 DT.75184922

DT.91938512 DT.100865547 DT.120676510 DT.40107648 DT.86840519 DT.40261948 DT.92380828

24/477 AceView cDNA sequences (see all 477):

BM773016 NM_020664 BM772996 CR621504 AA304771 CR595773 CR613066 BM013916

CR592051 AK094340 BQ670659 BM907295 AI672942 AA417373 BQ773593 BX096361

BM783793 BQ650649 Z45138 CR595072 BM760907 BM783209 BM750323 BG770530

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NME4 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	·	4c	·	4d	·	4e	^	5a	·	5b	·	5c	·	5d	·	5e	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10a	·	10b
SP1:																					-		-		-
SP2:																																							-
SP3:																																			-
SP4:																			-		-		-
SP5:													-		-		-		-		-														-

ECgene alternative splicing isoforms for NME4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NME4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGGTACAC

About this image

NME4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NME4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NME4

SOURCE GeneReport for Unigene cluster: Hs.9235

UniProtKB/Swiss-Prot: NDKM_HUMAN, O00746

Tissue specificity: Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and

skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes

SABiosciences Expression via Pathway-Focused PCR Array including NME4:

Tumor Metastasis in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NME4

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NME4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for NME4 gene from 9/30 species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NME4¹	NME/NM23 nucleoside diphosphate kinase 4	67.77(n) 63.74(a)		395915 XM_414724.3 XP_414724.3
lizard (Anolis carolinensis)	Reptilia	-- NME6⁶ (see all 4)	--	29(a) 24(a) (see all 4)	possible ortholog possible ortholog (see all 4)	6(47767459-47772252) GL343765.1(46424-53449)
African clawed frog (Xenopus laevis)	Amphibia	Xl.9894²	Xenopus laevis transcribed sequence with weak similarity more	74.65(n)		BJ029119.1
zebrafish (Danio rerio)	Actinopterygii	zgc56482²	similar to non-metastatic cells 4, protein expressed more	75.11(n)		394170 BC049030.1
fruit fly (Drosophila melanogaster)	Insecta	nmdyn-D7⁶ nmdyn-D6⁶	nmdyn-D6	5(a) 25(a)	possible ortholog possible ortholog	3R(5505661-5507224) X(14477710-14478649)
worm (Caenorhabditis elegans)	Secernentea	ndk-1⁶	Nucleoside diphosphate kinase	52(a)	possible ortholog	I(10553101-10553902)
thale cress (Arabidopsis thaliana)	eudicotyledons	NDPK1⁶ NDPK2⁶ (see all 6)	nucleoside diphosphate kinase II (see all 6)	48(a) 35(a) (see all 6)	possible ortholog possible ortholog (see all 6)	4(5923400-5924532) 5(25371904-25373861)
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	nucleoside diphosphate kinase, putative, expressed... nucleoside diphosphate kinase, putative, expressed... (see all 5)	52(a) 36(a) (see all 5)	possible ortholog possible ortholog (see all 5)	7(18333879-18336494) 10(22186387-22188912)
E. coli (Escherichia coli)	Gamma proteobacteria	ndk⁶	multifunctional nucleoside diphosphate kinase and ...	38(a)	possible ortholog	Chromosome(2642455-2642886)

ENSEMBL Gene Tree for NME4 (if available)
TreeFam Gene Tree for NME4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for NME4 gene

NME1² NME2² NME3² NME8² NME7² NME1-NME2² NME6² NME9²

NME5²

9 SIMAP similar genes for NME4 using alignment to 8 protein entries: NDKM_HUMAN (see all proteins):

NME3 NME2 NME1-NME2 c371H6.2 NME1 NME2P1

NME6 NME7 LOC402301

NME4 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for NME4
PGOHUM00000237341 PGOHUM00000250911 PGOHUM00000236422

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187100922^1,2		--	445335(+)	`CTCTAA/CAAAGA`	1	--	us2k¹		0	--	--	--	--
rs191924066^1,2		--	445347(+)	`AGAAAC/GTCACT`	1	--	us2k¹		0	--	--	--	--
rs4399536^1,2	C,F,H	--	445418(+)	`AGGCAC/TTCAGA`	1	--	us2k¹		12		NA WA CSA EA	374
rs77322976^1,2	F	--	445450(+)	`CGTCTC/GTATTC`	1	--	us2k¹		1		EA	120
rs60740176^1,2	C	--	445483(+)	`TTTTTTTT/-GAGAC`	1	--	us2k¹		1		NA	2
rs149041093^1,2	C	--	445483(+)	`TTTTC-/TTTTTTTT`	1	--	us2k¹		0	--	--	--	--
rs199585621^1,2		--	445486(+)	`CTTTT-/CTTTTT`	1	--	us2k¹		0	--	--	--	--
rs140831396^1,2		--	445550(+)	`GCTCTC/TGGCTC`	1	--	us2k¹		0	--	--	--	--
rs78655169^1,2	C	--	445643(+)	`TGTCCA/CGCTAA`	1	--	us2k¹		0	--	--	--	--
rs150166516^1,2		--	445658(+)	`TGTATA/TTTTAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NME4 (446725 - 460367 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NME4
3 CNVs: 3987 4912 5329

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NME4 for disorders           About GeneDecksing

OMIM gene information: 601818    OMIM disorders: --

14 diseases for NME4:    About MalaCards

fatal infantile lactic acidosis lactic acidosis cystic fibrosis diffuse astrocytoma

myelodysplastic syndrome fibrosis astrocytoma colon cancer

tuberculosis pneumonia pancreatitis malaria

prostatitis mycobacterium tuberculosis

4 Novoseek disease relationships for NME4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cystic fibrosis	43.4	1	10496900 (1)
metastasis	14.7	5	1325460 (1), 18621712 (1), 12874011 (1), 16757312 (1)
tumors	0	5	11343655 (2), 1325460 (1), 18621712 (1)
tuberculosis	0	2	9402029 (1), 15280044 (1)

Human Genome Epidemiology (HuGE) Navigator: NME4 (1 document)

Export disorders for NME4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NME4 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with NME4)

Utopia: connect your pdf to the dynamic
world of online information

nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13. (PubMed id 9099850)^{1, 2, 3, 9} Milon L.... Lacombe M.-L. (1997)
The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase. (PubMed id 10799505)^{1, 2, 9} Milon L.... Lacombe M.-L. (2000)
Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)^{1, 3} Desvignes T....Bobe J. (2009)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)^{1, 2} Martin J.... Pennacchio L.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)^{1, 2} Daniels R.J....Higgs D.R. (2001)
Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase. (PubMed id 11831846)^{1, 9} Kowluru A....Chen H.Q. (2002)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)¹ Richter R....Chrzanowska-Lightowlers Z.M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4833	HGNC: 7852	AceView: NME4andDECR2	Ensembl:ENSG00000103202	euGenes: HUgn4833
ECgene: NME4	Kegg: 4833	H-InvDB: NME4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NME4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NME4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NME4 gene
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Patent Information for NME4 gene:
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GeneCards and IP:
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NME/NM23 nucleoside diphosphate kinase 4

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NME/NM23 nucleoside diphosphate kinase 4

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