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Aliases for NME3 Gene

Aliases for NME3 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 3 2 3 5
  • Non-Metastatic Cells 3, Protein Expressed In 2 3
  • Nucleoside Diphosphate Kinase C 3 4
  • NDP Kinase 3 3 4
  • EC 4 58
  • NM23-H3 3 4
  • DR-Nm23 3 4
  • NDK 3 3 4
  • NDPKC 3 4
  • Nucleoside Diphosphate Kinase 3 3
  • NDP Kinase C 3
  • C371H6.2 3
  • NDPK-C 3
  • NM23H3 3

External Ids for NME3 Gene

Previous GeneCards Identifiers for NME3 Gene

  • GC16M001837
  • GC16M001760
  • GC16M001820

Summaries for NME3 Gene

GeneCards Summary for NME3 Gene

NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3) is a Protein Coding gene. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Pyrimidine metabolism (KEGG). GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME1.

UniProtKB/Swiss-Prot for NME3 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.

Gene Wiki entry for NME3 Gene

Additional gene information for NME3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME3 Gene

Genomics for NME3 Gene

Regulatory Elements for NME3 Gene

Enhancers for NME3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H001308 1.4 ENCODE dbSUPER 64.1 +461.0 461004 5.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 MCM3 NFYC WDR90 CRAMP1 ENSG00000261505 TELO2 UBE2I E4F1 TSC2 ENSG00000260051 JMJD8 RHOT2
GH16H001271 1.1 ENCODE 53.8 +499.9 499932 1.6 PKNOX1 SIN3A FEZF1 ZNF2 ZNF302 ZNF416 SP3 REST ZNF662 ZNF592 CRAMP1 WDR90 TELO2 IFT140 ENSG00000261505 TSC2 E4F1 WDR24 ENSG00000260646 UBE2I
GH16H002602 2.4 ENCODE dbSUPER 13.6 -831.9 -831859 1.7 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A PPARGC1A SSRP1 TBL3 ZNF597 AMDHD2 ENSG00000226890 SRRM2 ENSG00000200059 TIGD7 ZNF263 ENSG00000261240 ZNF598
GH16H001473 1.3 ENCODE dbSUPER 24.9 +296.8 296799 2.3 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF207 ZNF143 FOS IFT140 UBE2I WDR90 CRAMP1 TELO2 TSC2 NME3 CLCN7 ENSG00000260646 E4F1
GH16H002511 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -744.7 -744695 10.7 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS ZNF75A CRAMP1 TBC1D24 IFT140 ZNF213-AS1 ZNF174 ZNF263 ERVK13-1 TSC2 SNHG19
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NME3 on UCSC Golden Path with GeneCards custom track

Promoters for NME3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082385 -642 3201 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Locations for NME3 Gene

Genomic Locations for NME3 Gene
1,473 bases
Minus strand

Genomic View for NME3 Gene

Genes around NME3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME3 Gene

Proteins for NME3 Gene

  • Protein details for NME3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleoside diphosphate kinase 3
    Protein Accession:
    Secondary Accessions:
    • Q9BWH4

    Protein attributes for NME3 Gene

    169 amino acids
    Molecular mass:
    19015 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NME3 Gene

neXtProt entry for NME3 Gene

Selected DME Specific Peptides for NME3 Gene


Post-translational modifications for NME3 Gene

  • Ubiquitination at Lys29 and Lys51
  • Modification sites at PhosphoSitePlus

Domains & Families for NME3 Gene

Gene Families for NME3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for NME3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NDK family.
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME3: view

Function for NME3 Gene

Molecular function for NME3 Gene

GENATLAS Biochemistry:
non-metastatic cells 3,protein,with a nm23 nucleoside diphosphate kinase gene family,preferentially expressed at early stage of myeloid differentiation,involved in the phosphorylation of nucleoside diphophates,inhibiting granulocyte differentiation and inducing apoptosis
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.

Enzyme Numbers (IUBMB) for NME3 Gene

Gene Ontology (GO) - Molecular Function for NME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity TAS,IEA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NME3: view
genes like me logo Genes that share phenotypes with NME3: view

Animal Models for NME3 Gene

MGI Knock Outs for NME3:

Animal Model Products

CRISPR Products

miRNA for NME3 Gene

miRTarBase miRNAs that target NME3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NME3

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NME3 Gene

Localization for NME3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NME3 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NME3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NME3 Gene

Pathways & Interactions for NME3 Gene

genes like me logo Genes that share pathways with NME3: view

Gene Ontology (GO) - Biological Process for NME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0006915 apoptotic process TAS,IEA --
genes like me logo Genes that share ontologies with NME3: view

No data available for SIGNOR curated interactions for NME3 Gene

Drugs & Compounds for NME3 Gene

(11) Drugs for NME3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
dATP Experimental Pharma Full agonist, Agonist 0
dctp Experimental Pharma 0
dgtp Experimental Pharma 0

(12) Additional Compounds for NME3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxy-Inosine 5'-(tetrahydrogen triphosphate)
  • 2'-Deoxyinosine-5'-triphosphate
  • 2'-Ditp
  • Deoxyinosine 5'-triphosphate
  • Deoxyinosine triphosphate
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
genes like me logo Genes that share compounds with NME3: view

Transcripts for NME3 Gene

mRNA/cDNA for NME3 Gene

Unigene Clusters for NME3 Gene

NME/NM23 nucleoside diphosphate kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NME3

Alternative Splicing Database (ASD) splice patterns (SP) for NME3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP7: -

Relevant External Links for NME3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NME3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NME3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NME3 Gene

This gene is overexpressed in Nasal epithelium (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NME3 Gene

Protein tissue co-expression partners for NME3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NME3 Gene:


SOURCE GeneReport for Unigene cluster for NME3 Gene:


Evidence on tissue expression from TISSUES for NME3 Gene

  • Eye(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with NME3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NME3 Gene

Orthologs for NME3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NME3 34 33
  • 99.01 (n)
(Bos Taurus)
Mammalia NME3 33 34
  • 90.93 (n)
(Canis familiaris)
Mammalia NME3 33 34
  • 86.88 (n)
(Monodelphis domestica)
Mammalia NME3 34
  • 85 (a)
(Rattus norvegicus)
Mammalia Nme3 33
  • 83.04 (n)
(Mus musculus)
Mammalia Nme3 33 16 34
  • 82.64 (n)
(Gallus gallus)
Aves NME4 33
  • 77.48 (n)
NME3 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nme3 33
  • 71.4 (n)
Str.10886 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33976 33
(Danio rerio)
Actinopterygii nme3 33 34
  • 68.06 (n)
ndpkz3 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10233 33
fruit fly
(Drosophila melanogaster)
Insecta awd 35 34
  • 66 (a)
(Caenorhabditis elegans)
Secernentea F25H2.5 35
  • 57 (a)
ndk-1 34
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 34
  • 58 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NDPK2 33
  • 52.48 (n)
(Oryza sativa)
Liliopsida Os12g0548300 33
  • 56.53 (n)
(Hordeum vulgare)
Liliopsida Hv.704 33
(Triticum aestivum)
Liliopsida Ta.2227 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
Species where no ortholog for NME3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NME3 Gene

Gene Tree for NME3 (if available)
Gene Tree for NME3 (if available)

Paralogs for NME3 Gene

Paralogs for NME3 Gene

(8) SIMAP similar genes for NME3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NME3: view

Variants for NME3 Gene

Sequence variations from dbSNP and Humsavar for NME3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000080954 -- 1,770,394(+) GGCTG(C/G)GCACC downstream-variant-500B, utr-variant-3-prime
rs1000437713 -- 1,770,124(+) GCTGC(C/G)GGCTT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000745474 -- 1,769,965(+) CTCTC(C/T)GGCCT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000988298 -- 1,773,005(+) GGTCT(C/T)GTAGT upstream-variant-2KB, reference, missense
rs1001188624 -- 1,770,889(+) CCAAC(C/T)TCGAT reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for NME3 Gene

Variant ID Type Subtype PubMed ID
nsv952900 CNV deletion 24416366
nsv827500 CNV gain 20364138
nsv571173 CNV loss 21841781
nsv571172 CNV loss 21841781
nsv571171 CNV gain+loss 21841781
nsv571170 CNV loss 21841781
nsv571169 CNV loss 21841781
nsv518641 CNV loss 19592680
nsv517196 CNV gain+loss 19592680
nsv471069 CNV loss 18288195
nsv457336 CNV loss 19166990
nsv457335 CNV loss 19166990
nsv1160328 CNV deletion 26073780
nsv1051692 CNV loss 25217958
esv3892756 CNV loss 25118596
esv2422427 CNV duplication 17116639
dgv4856n54 CNV loss 21841781

Variation tolerance for NME3 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NME3 Gene

Disorders for NME3 Gene

Relevant External Links for NME3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NME3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NME3 Gene

Publications for NME3 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  2. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T … Bobe J (BMC evolutionary biology 2009) 2 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Structural and catalytic properties and homology modelling of the human nucleoside diphosphate kinase C, product of the DRnm23 gene. (PMID: 11277919) Erent M … Lascu I (European journal of biochemistry 2001) 3 22 60
  5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 60

Products for NME3 Gene

  • Addgene plasmids for NME3

Sources for NME3 Gene

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