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Aliases for NME3 Gene

Aliases for NME3 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 3 2 3 5
  • Non-Metastatic Cells 3, Protein Expressed In 2 3
  • Nucleoside Diphosphate Kinase C 3 4
  • NDP Kinase 3 3 4
  • EC 2.7.4.6 4 63
  • NM23-H3 3 4
  • DR-Nm23 3 4
  • NDK 3 3 4
  • NDPKC 3 4
  • NDP Kinase C 3
  • C371H6.2 3
  • NDPK-C 3
  • NM23H3 3

External Ids for NME3 Gene

Previous GeneCards Identifiers for NME3 Gene

  • GC16M001837
  • GC16M001760
  • GC16M001820

Summaries for NME3 Gene

GeneCards Summary for NME3 Gene

NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3) is a Protein Coding gene. Among its related pathways are Metabolism and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME3 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.

Gene Wiki entry for NME3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME3 Gene

Genomics for NME3 Gene

Regulatory Elements for NME3 Gene

Promoters for NME3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NME3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NME3 Gene

Chromosome:
16
Start:
1,770,286 bp from pter
End:
1,771,758 bp from pter
Size:
1,473 bases
Orientation:
Minus strand

Genomic View for NME3 Gene

Genes around NME3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME3 Gene

Proteins for NME3 Gene

  • Protein details for NME3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13232-NDK3_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase 3
    Protein Accession:
    Q13232
    Secondary Accessions:
    • Q9BWH4

    Protein attributes for NME3 Gene

    Size:
    169 amino acids
    Molecular mass:
    19015 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NME3 Gene

neXtProt entry for NME3 Gene

Proteomics data for NME3 Gene at MOPED

Selected DME Specific Peptides for NME3 Gene

Post-translational modifications for NME3 Gene

  • Ubiquitination at Lys 29 and Lys 51
  • Modification sites at PhosphoSitePlus

Other Protein References for NME3 Gene

Antibody Products

Domains & Families for NME3 Gene

Gene Families for NME3 Gene

Protein Domains for NME3 Gene

Suggested Antigen Peptide Sequences for NME3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13232

UniProtKB/Swiss-Prot:

NDK3_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME3: view

Function for NME3 Gene

Molecular function for NME3 Gene

GENATLAS Biochemistry:
non-metastatic cells 3,protein,with a nm23 nucleoside diphosphate kinase gene family,preferentially expressed at early stage of myeloid differentiation,involved in the phosphorylation of nucleoside diphophates,inhibiting granulocyte differentiation and inducing apoptosis
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.

Enzyme Numbers (IUBMB) for NME3 Gene

Gene Ontology (GO) - Molecular Function for NME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NME3: view
genes like me logo Genes that share phenotypes with NME3: view

Animal Models for NME3 Gene

MGI Knock Outs for NME3:

Animal Model Products

miRNA for NME3 Gene

miRTarBase miRNAs that target NME3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NME3 Gene

Localization for NME3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NME3 Gene COMPARTMENTS Subcellular localization image for NME3 gene
Compartment Confidence
extracellular 5
mitochondrion 4
cytoskeleton 2
cytosol 2
chloroplast 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NME3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NME3 Gene

Pathways & Interactions for NME3 Gene

genes like me logo Genes that share pathways with NME3: view

Gene Ontology (GO) - Biological Process for NME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006163 purine nucleotide metabolic process IBA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006220 pyrimidine nucleotide metabolic process IBA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with NME3: view

No data available for SIGNOR curated interactions for NME3 Gene

Drugs & Compounds for NME3 Gene

(11) Drugs for NME3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
dctp Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0

(12) Additional Compounds for NME3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxy-Inosine 5'-(tetrahydrogen triphosphate)
  • 2'-Deoxyinosine-5'-triphosphate
  • 2'-Ditp
  • Deoxyinosine 5'-triphosphate
  • Deoxyinosine triphosphate
16595-02-1
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
1173-82-6
genes like me logo Genes that share compounds with NME3: view

Transcripts for NME3 Gene

mRNA/cDNA for NME3 Gene

Unigene Clusters for NME3 Gene

NME/NM23 nucleoside diphosphate kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NME3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6:
SP7: -

Relevant External Links for NME3 Gene

GeneLoc Exon Structure for
NME3
ECgene alternative splicing isoforms for
NME3

Expression for NME3 Gene

mRNA expression in normal human tissues for NME3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NME3 Gene

This gene is overexpressed in Nasal epithelium (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NME3 Gene



SOURCE GeneReport for Unigene cluster for NME3 Gene Hs.514065

genes like me logo Genes that share expression patterns with NME3: view

Protein tissue co-expression partners for NME3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NME3 Gene

Orthologs for NME3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NME3 35
  • 90.93 (n)
  • 94.67 (a)
NME3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NME3 35
  • 86.88 (n)
  • 87.1 (a)
NME3 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nme3 35
  • 82.64 (n)
  • 88.76 (a)
Nme3 16
Nme3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NME3 35
  • 99.01 (n)
  • 99.37 (a)
NME3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nme3 35
  • 83.04 (n)
  • 90.53 (a)
oppossum
(Monodelphis domestica)
Mammalia NME3 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves NME4 35
  • 77.48 (n)
  • 78.38 (a)
NME3 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nme3 35
  • 71.4 (n)
  • 72.19 (a)
Str.10886 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33976 35
zebrafish
(Danio rerio)
Actinopterygii ndpkz3 35
nme3 35
  • 68.06 (n)
  • 73.21 (a)
nme3 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10233 35
fruit fly
(Drosophila melanogaster)
Insecta awd 37
  • 66 (a)
awd 36
  • 60 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F25H2.5 37
  • 57 (a)
ndk-1 36
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 36
  • 58 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NDPK2 35
  • 52.48 (n)
  • 52.7 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.704 35
rice
(Oryza sativa)
Liliopsida Os12g0548300 35
  • 56.53 (n)
  • 54.73 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2227 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToMany
Species with no ortholog for NME3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NME3 Gene

ENSEMBL:
Gene Tree for NME3 (if available)
TreeFam:
Gene Tree for NME3 (if available)

Paralogs for NME3 Gene

Paralogs for NME3 Gene

(8) SIMAP similar genes for NME3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NME3: view

Variants for NME3 Gene

Sequence variations from dbSNP and Humsavar for NME3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11890 -- 1,770,991(-) CAGGT(A/G/T)TGGCA reference, synonymous-codon, missense
rs1131373 -- 1,771,171(-) TGCAG(G/T)CCTCC reference, synonymous-codon, missense
rs11543214 -- 1,770,952(-) GCGCT(A/C)ATCGG reference, synonymous-codon, stop-gained
rs12447827 -- 1,771,192(+) GCCGC(A/C)TGCGC intron-variant
rs113812579 -- 1,771,106(+) TTGAC(A/C/G)AGGCG reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for NME3 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904954 CNV Loss 21882294
nsv905017 CNV Loss 21882294
nsv518641 CNV Loss 19592680
nsv457335 CNV Loss 19166990
dgv2538n71 CNV Loss 21882294
nsv517196 CNV Gain+Loss 19592680
nsv905023 CNV Gain 21882294
dgv2539n71 CNV Loss 21882294
dgv2540n71 CNV Loss 21882294
nsv457336 CNV Loss 19166990
nsv905030 CNV Loss 21882294
nsv471069 CNV Loss 18288195
dgv2541n71 CNV Loss 21882294
nsv905031 CNV Gain+Loss 21882294
dgv2542n71 CNV Loss 21882294
nsv905034 CNV Loss 21882294
nsv827500 CNV Gain 20364138
dgv2543n71 CNV Loss 21882294
nsv905039 CNV Loss 21882294

Variation tolerance for NME3 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME3 Gene

HapMap Linkage Disequilibrium report
NME3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NME3 Gene

Disorders for NME3 Gene

Relevant External Links for NME3

Genetic Association Database (GAD)
NME3
Human Genome Epidemiology (HuGE) Navigator
NME3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NME3

No disorders were found for NME3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NME3 Gene

Publications for NME3 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T. … Bobe J. (BMC Evol. Biol. 2009) 2 3
  3. Structural and catalytic properties and homology modelling of the human nucleoside diphosphate kinase C, product of the DRnm23 gene. (PMID: 11277919) Erent M. … Lascu I. (Eur. J. Biochem. 2001) 3 23
  4. Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family. (PMID: 9067290) Martinez R. … Calabretta B. (Cancer Res. 1997) 2 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for NME3 Gene

Sources for NME3 Gene

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