Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NME3 Gene

protein-coding   GIFtS: 68
GCID: GC16M001820

NME/NM23 Nucleoside Diphosphate Kinase 3

(Previous names: non-metastatic cells 3, protein expressed in)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
NME/NM23 Nucleoside Diphosphate Kinase 31 2     NM23H32 5
Non-Metastatic Cells 3, Protein Expressed In1 2     NDPK-C2
Nucleoside Diphosphate Kinase C2 3     NM23-H32
DR-nm232 3     c371H6.22
NDPKC2 3     NDP Kinase C2
NDK 32 3     Nucleoside Diphosphate Kinase 32
NDP Kinase 32 3     nm23-H33
EC 2.7.4.63 8     

External Ids:    HGNC: 78511   Entrez Gene: 48322   Ensembl: ENSG000001030247   OMIM: 6018175   UniProtKB: Q132323   

Export aliases for NME3 gene to outside databases

Previous GC identifers: GC16M001837 GC16M001760


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for NME3 Gene:
NME3 (NME/NM23 nucleoside diphosphate kinase 3) is a protein-coding gene. Diseases associated with NME3 include pneumonia, and neuroblastoma. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME2.

UniProtKB/Swiss-Prot: NDK3_HUMAN, Q13232
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is
transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of
apoptosis

Gene Wiki entry for NME3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NME3 gene promoter:
         USF1   Tal-1   Pax-5   Olf-1   GATA-1   E47   YY1   Roaz   GATA-2   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNME3 promoter sequence
   Search Chromatin IP Primers for NME3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16q13.3

NME3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M001820:  view genomic region     (about GC identifiers)

Start:
1,820,287 bp from pter      End:
1,821,731 bp from pter
Size:
1,445 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NDK3_HUMAN, Q13232 (See protein sequence)
Recommended Name: Nucleoside diphosphate kinase 3  
Size: 169 amino acids; 19015 Da
Cofactor: Magnesium (By similarity)
Developmental stage: Preferentially expressed at early stages of myeloid differentiation of highly purified CD34+
cells
1 PDB 3D structure from and Proteopedia for NME3:
1ZS6 (3D)    
Secondary accessions: Q9BWH4

Explore the universe of human proteins at neXtProt for NME3: NX_Q13232

Explore proteomics data for NME3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys29, Lys51
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NME3 (Q13232) (see all 5)
     PGTIRGD  KPDGVQR  HGSDSVE  REIALWF 


    See NME3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002504.2  
    ENSEMBL proteins: 
     ENSP00000219302   ENSP00000456160   ENSP00000455271   ENSP00000455435   ENSP00000454498  

    NME3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NME3
    GenScript Custom Purified and Recombinant Proteins Services for NME3
    Novus Biologicals NME3 Proteins
    Novus Biologicals NME3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NME3
    Cloud-Clone Corp. Proteins for NME3

    NME3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NME3
    OriGene Custom Antibody Services for NME3
    Novus Biologicals NME3 Antibodies
    Abcam antibodies for NME3
    Cloud-Clone Corp. Antibodies for NME3
    ThermoFisher Antibodies for NME3
    LSBio Antibodies in human, mouse, rat for NME3

    NME3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NME3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NME3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NME3
    Cloud-Clone Corp. CLIAs for NME3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR023005 Nucleoside_diP_kinase_AS
     IPR001564 Nucleoside_diP_kinase

    Graphical View of Domain Structure for InterPro Entry Q13232

    ProtoNet protein and cluster: Q13232

    1 Blocks protein domain: IPB001564 Nucleoside diphosphate kinase

    UniProtKB/Swiss-Prot: NDK3_HUMAN, Q13232
    Similarity: Belongs to the NDK family


    NME3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDK3_HUMAN, Q13232
    Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is
    transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of
    apoptosis
    Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

         Genatlas biochemistry entry for NME3:
    non-metastatic cells 3,protein,with a nm23 nucleoside diphosphate kinase gene family,preferentially expressed at
    early stage of myeloid differentiation,involved in the phosphorylation of nucleoside diphophates,inhibiting
    granulocyte differentiation and inducing apoptosis

         Enzyme Number (IUBMB): EC 2.7.4.61 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004550nucleoside diphosphate kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--
         
    NME3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NME3:
     Decreased focal adhesion (FA)   Decreased viability 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nme3):
     reproductive system 

    NME3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nme3tm1Bgh for NME3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NME3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NME3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NME3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NME3

    miRNA
    Products:
        
    miRTarBase miRNAs that target NME3:
    hsa-mir-324-5p (MIRT043040)

    Block miRNA regulation of human, mouse, rat NME3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NME3
    SwitchGear 3'UTR luciferase reporter plasmidNME3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NME3
    Predesigned siRNA for gene silencing in human, mouse, rat NME3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NME3

    Clone
    Products:
         
    OriGene clones in human, mouse for NME3 (see all 6)
    OriGene ORF clones in mouse, rat for NME3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NME3 (NM_002513)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NME3
    Browse ESI BIO Cell Lines and PureStem Progenitors for NME3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    chloroplast2
    cytoskeleton2
    cytosol2
    mitochondrion2
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    NME3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NME3 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    Pyrimidine metabolism0.38
    purine deoxyribonucleosides salvage0.00
    2superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
    adenosine deoxyribonucleotides de novo biosynthesis0.00
    guanosine deoxyribonucleotides de novo biosynthesis0.52
    pyrimidine deoxyribonucleotides de novo biosynthesis0.00
    superpathway of pyrimidine deoxyribonucleoside salvage0.46
    UTP and CTP de novo biosynthesis0.00
    CMP phosphorylation0.00
    superpathway of pyrimidine ribonucleotides de novo biosynthesis0.00
    3purine nucleotide salvage
    purine nucleotide salvage0.78
    guanosine nucleotides de novo biosynthesis0.00
    purine nucleotides de novo biosynthesis0.78
    guanosine ribonucleotides de novo biosynthesis0.00
    4Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NME3
        ATP/ITP metabolism

    Selected BioSystems Pathways for NME3 (see all 15)
        purine nucleotides de novo biosynthesis
    superpathway of pyrimidine ribonucleotides de novo biosynthesis
    purine deoxyribonucleosides salvage
    guanosine nucleotides de novo biosynthesis
    purine nucleotide salvage


    3 Kegg Pathways  (Kegg details for NME3):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways


    NME3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NME3: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NME3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NME3 (Q132322, 3 ENSP000002193024) via UniProtKB, MINT, STRING, and/or I2D (see all 110)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME2P223922, 3, ENSP000003655724MINT-64130 I2D: score=6 STRING: ENSP00000365572
    NME1P155312, 3, ENSP000000130344MINT-68402 I2D: score=6 STRING: ENSP00000013034
    NME1-NME2P223922, 3MINT-64130 I2D: score=6 
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2861202 MINT-2861221 I2D: score=3 STRING: ENSP00000357292
    SGTAO437652, 3, ENSP000002215664MINT-67252 I2D: score=5 STRING: ENSP00000221566
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006165nucleoside diphosphate phosphorylation ----
    GO:0006183GTP biosynthetic process IEA--
    GO:0006228UTP biosynthetic process IEA--
    GO:0006241CTP biosynthetic process IEA--
    GO:0006915apoptotic process IEA--

    NME3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NME3 (NDK3)

    9 HMDB Compounds for NME3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CDPCDP (see all 3)63-38-7--
    Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--
    dTDPDeoxy-tdp (see all 5)491-97-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NME3 gene: 
    NM_002513.2  

    Unigene Cluster for NME3:

    NME/NM23 nucleoside diphosphate kinase 3
    Hs.514065  [show with all ESTs]
    Unigene Representative Sequence: BU196357
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219302(uc002cmm.3 uc010brv.3) ENST00000564628 ENST00000561637
    ENST00000567271 ENST00000568561 ENST00000563498 ENST00000566600 ENST00000563367
    ENST00000565379 ENST00000563854 ENST00000564252
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NME3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NME3
    SwitchGear 3'UTR luciferase reporter plasmidNME3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NME3
    Predesigned siRNA for gene silencing in human, mouse, rat NME3
    Clone
    Products:
         
    OriGene clones in human, mouse for NME3 (see all 6)
    OriGene ORF clones in mouse, rat for NME3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NME3 (NM_002513)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NME3
    OriGene qSTAR qPCR primer pairs in human, mouse for NME3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NME3
      QuantiTect SYBR Green Assays in human, mouse, rat NME3
      QuantiFast Probe-based Assays in human, mouse, rat NME3

    Additional mRNA sequence: 

    AK308663.1 BC000250.1 U29656.1 

    12 DOTS entries:

    DT.100782593  DT.445711  DT.100783150  DT.100783151  DT.91751817  DT.100783153  DT.91751819  DT.100783149 
    DT.97847568  DT.100700725  DT.120722422  DT.95102725 

    13 AceView cDNA sequences:

    BM310157 BQ316455 BQ316453 CR605551 NM_002513 CD615033 BC000250 CD615041 
    CD615039 U29656 BM309876 CD615036 CD615035 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NME3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f
    SP1:              -           -     -                             -                                       
    SP2:              -           -     -                             -                                       
    SP3:              -           -     -                       -     -                                       
    SP4:                          -     -                             -                                       
    SP5:                          -                                   -                                       


    ECgene alternative splicing isoforms for NME3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NME3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGTGGCG
    NME3 Expression
    About this image


    NME3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Ovarian Somatic Cells Ovigerous Cord
     
     Lung (Respiratory System)
    NME3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NME3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514065
        Pathway & Disease-focused RT2 Profiler PCR Array including NME3: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NME3
    OriGene qSTAR qPCR primer pairs in human, mouse for NME3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NME3
    QuantiTect SYBR Green Assays in human, mouse, rat NME3
    QuantiFast Probe-based Assays in human, mouse, rat NME3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NME3 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nme31 , 5 non-metastatic cells 3, protein expressed in5
    NME/NM23 nucleoside diphosphate kinase 31
    82.64(n)1
    88.76(a)1
      17 (12.53 cM)5
    790591  NM_019730.21  NP_062704.21 
     248965005 
    chicken
    (Gallus gallus)
    Aves NME41 NME/NM23 nucleoside diphosphate kinase 4 77.48(n)
    78.38(a)
      395915  XM_414724.4  XP_414724.4 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.339762 Xenopus laevis transcribed sequence with moderate similarity more 75.39(n)    CB944254.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ndpkz32 nucleoside diphosphate kinase-Z3 72.41(n)   30085  AF202054.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta awd3 CTP biosynthesis nucleoside-diphosphate
    kinase
    66(a)   100D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea F25H2.53 nucleoside diphosphate kinase 57(a)   I(10561041-10562106)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YNK16
    Nucleoside diphosphate kinase, catalyzes the trans...
    58(a)
    1 → many
    XI(314812-315273) YKL067W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NDPK21 NDPK2 52.48(n)
    52.7(a)
      836451  NM_125726.3  NP_568970.2 
    rice
    (Oryza sativa)
    Liliopsida Os12g05483001 Os12g0548300 56.53(n)
    54.73(a)
      4352460  NM_001073503.1  NP_001066971.1 


    ENSEMBL Gene Tree for NME3 (if available)
    TreeFam Gene Tree for NME3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NME3 gene
    NME22  NME12  NME82  NME42  NME72  NME1-NME22  NME62  NME92  
    NME52  
    8 SIMAP similar genes for NME3 using alignment to 5 protein entries:     NDK3_HUMAN (see all proteins):
    c371H6.2    NME1    NME2    NME1-NME2    NME4    NME2P1
    NME7    NME6

    NME3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NME3 (see all 29)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168463381,2
    F--1820836(+) GAACAG/CGGGGA 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1845105881,2
    C--1820856(+) GGGCTA/GGGACC 1 -- int10--------
    rs2011048301,2
    C--1820885(+) ACTTGA/CCAACC 2 G V mis10--------
    rs115432141,2
    C--1820953(-) GCGCTC/AATCGG 2 /L syn1 ese32Minor allele frequency- A:0.00NA 4
    rs1890344901,2
    C--1820969(+) AGGTGC/TGCACC 2 H R mis10--------
    rs118901,2
    C,F,A--1820992(-) CAGGTT/ATGGCA 2 /V syn1 ese313Minor allele frequency- A:0.37MN EA NA WA CSA EU 1873
    rs1813428611,2
    C--1821082(+) CACCAA/CCGGCC 2 V L mis10--------
    rs1138125791,2
    C--1821107(+) TTGACA/GAGGCG 2 L syn10--------
    rs2000144891,2
    --1821146(+) GCGTAA/GTGCTC 2 H syn10--------
    rs2021377851,2
    C--1821166(+) CTCCTC/TGGAGG 2 K E mis10--------

    HapMap Linkage Disequilibrium report for NME3 (1820287 - 1821731 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NME3 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv904954CNV Loss21882294
    nsv905030CNV Loss21882294
    dgv2541n71CNV Loss21882294
    nsv457336CNV Loss19166990
    dgv2540n71CNV Loss21882294
    nsv905017CNV Loss21882294
    dgv2539n71CNV Loss21882294
    nsv905034CNV Loss21882294
    nsv518641CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NME3
    DNA2.0 Custom Variant and Variant Library Synthesis for NME3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601817    OMIM disorders: --

    5 diseases for NME3:    
    About MalaCards
    pneumonia    neuroblastoma    tuberculosis    ataxia
    squamous cell carcinoma


    NME3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NME3
    Human Genome Epidemiology (HuGE) Navigator: NME3 (1 document)

    Export disorders for NME3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NME3 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with NME3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)1, 3 Desvignes T....Bobe J. (BMC Evol. Biol. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    5. Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family. (PubMed id 9067290)1, 3 Martinez R....Calabretta B. (Cancer Res. 1997)
    6. Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells. (PubMed id 7638209)1, 2 Venturelli D.... Calabretta B. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    7. Structural and catalytic properties and homology modelling of the human nucleoside diphosphate kinase C, product of the DRnm23 gene. (PubMed id 11277919)1, 9 Erent M....Lascu I. (Eur. J. Biochem. 2001)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4832 HGNC: 7851 AceView: NME3 Ensembl:ENSG00000103024 euGenes: HUgn4832
    ECgene: NME3 Kegg: 4832 H-InvDB: NME3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NME3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NME3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NME3 gene:
    Search GeneIP for patents involving NME3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NME3   OriGene RNAi products in human, mouse, rat for NME3  
     OriGene qPCR primer pairs and template standards for NME3   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NME3  
     OriGene qSTAR qPCR primer pairs in human, mouse for NME3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NME3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NME3   OriGene Custom Protein Services for NME3  

     
     
     Block miRNA regulation of human, mouse, rat NME3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NME3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME3 Predesigned siRNA for gene silencing in human, mouse, rat NME3
     QuantiFast Probe-based Assays in human, mouse, rat NME3 QuantiTect SYBR Green Assays in human, mouse, rat NME3
     PCR Arrays including human, mouse, rat NME3 Search Chromatin IP Primers for NME3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NME3  GeneGlobe Interaction Network for NME3
     Regulatory tfbs in NME3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NME3 GenScript cDNA clones with any tag delivered in your preferred vector for NME3
     GenScript Custom Assay Services for NME3 GenScript Custom overexpressing Cell Line Services for NME3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NME3 (NDK3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NME3 antibodies
     NME3 proteins
     NME3 lysates
     Antibodies for NME3
     See all of Abcam's Antibodies, Kits and Proteins for NME3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for NME3
     Proteins for NME3
     Antibodies for NME3
     ELISAs for NME3
     CLIAs for NME3



     Browse ESI BIO Cell Lines and PureStem Progenitors for NME3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME3
     SwitchGear 3'UTR luciferase reporter plasmids for NME3
     SwitchGear Promoter luciferase reporter plasmids for NME3
     ThermoFisher Antibodies for NME3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NME3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NME3
     LSBio Antibodies in human, mouse, rat for NME3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NME3 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4