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Aliases for NME3 Gene

Aliases for NME3 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 3 2 3
  • Non-Metastatic Cells 3, Protein Expressed In 2 3
  • Nucleoside Diphosphate Kinase C 3 4
  • NDP Kinase 3 3 4
  • EC 2.7.4.6 4 63
  • NM23-H3 3 4
  • DR-Nm23 3 4
  • NM23H3 3 6
  • NDK 3 3 4
  • NDPKC 3 4
  • Nucleoside Diphosphate Kinase 3 3
  • NDP Kinase C 3
  • C371H6.2 3
  • NDPK-C 3

External Ids for NME3 Gene

Previous GeneCards Identifiers for NME3 Gene

  • GC16M001837
  • GC16M001760
  • GC16M001820

Summaries for NME3 Gene

GeneCards Summary for NME3 Gene

NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3) is a Protein Coding gene. Among its related pathways are Metabolism and purine nucleotide salvage. GO annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME3 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis

Gene Wiki entry for NME3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME3 Gene

Genomics for NME3 Gene

Regulatory Elements for NME3 Gene

Genomic Location for NME3 Gene

Start:
1,770,286 bp from pter
End:
1,771,730 bp from pter
Size:
1,445 bases
Orientation:
Minus strand

Genomic View for NME3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NME3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME3 Gene

Proteins for NME3 Gene

  • Protein details for NME3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13232-NDK3_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase 3
    Protein Accession:
    Q13232
    Secondary Accessions:
    • Q9BWH4

    Protein attributes for NME3 Gene

    Size:
    169 amino acids
    Molecular mass:
    19015 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NME3 Gene

neXtProt entry for NME3 Gene

Proteomics data for NME3 Gene at MOPED

Selected DME Specific Peptides for NME3 Gene

Post-translational modifications for NME3 Gene

  • Ubiquitination at Lys29 and Lys51
  • Modification sites at PhosphoSitePlus

Other Protein References for NME3 Gene

Domains for NME3 Gene

Protein Domains for NME3 Gene

Suggested Antigen Peptide Sequences for NME3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13232

UniProtKB/Swiss-Prot:

NDK3_HUMAN :
  • Q13232
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME3: view

No data available for Gene Families for NME3 Gene

Function for NME3 Gene

Molecular function for NME3 Gene

GENATLAS Biochemistry: non-metastatic cells 3,protein,with a nm23 nucleoside diphosphate kinase gene family,preferentially expressed at early stage of myeloid differentiation,involved in the phosphorylation of nucleoside diphophates,inhibiting granulocyte differentiation and inducing apoptosis
UniProtKB/Swiss-Prot CatalyticActivity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
UniProtKB/Swiss-Prot Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis

Enzyme Numbers (IUBMB) for NME3 Gene

Gene Ontology (GO) - Molecular Function for NME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NME3: view

Phenotypes for NME3 Gene

MGI mutant phenotypes for NME3:
inferred from 1 alleles
GenomeRNAi human phenotypes for NME3:
genes like me logo Genes that share phenotypes with NME3: view

Animal Models for NME3 Gene

MGI Knock Outs for NME3:

miRNA for NME3 Gene

miRTarBase miRNAs that target NME3

No data available for Transcription Factor Targeting and HOMER Transcription for NME3 Gene

Localization for NME3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NME3 Gene COMPARTMENTS Subcellular localization image for NME3 gene
Compartment Confidence
extracellular 3
chloroplast 2
cytoskeleton 2
cytosol 2
mitochondrion 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0005829 cytosol IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NME3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NME3 Gene

Pathways for NME3 Gene

genes like me logo Genes that share pathways with NME3: view

Gene Ontology (GO) - Biological Process for NME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006163 purine nucleotide metabolic process IBA --
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006220 pyrimidine nucleotide metabolic process IBA --
GO:0006228 UTP biosynthetic process IEA --
genes like me logo Genes that share ontologies with NME3: view

Compounds for NME3 Gene

(9) HMDB Compounds for NME3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
CDP
  • CDP
63-38-7
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)
65-47-4
dTDP
  • Deoxy-tdp
491-97-4
genes like me logo Genes that share compounds with NME3: view

Transcripts for NME3 Gene

mRNA/cDNA for NME3 Gene

(13) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NME3 Gene

NME/NM23 nucleoside diphosphate kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NME3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6:
SP7: -

Relevant External Links for NME3 Gene

GeneLoc Exon Structure for
NME3
ECgene alternative splicing isoforms for
NME3

Expression for NME3 Gene

mRNA expression in normal human tissues for NME3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NME3 Gene

SOURCE GeneReport for Unigene cluster for NME3 Gene Hs.514065

genes like me logo Genes that share expressions with NME3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NME3 Gene

Orthologs for NME3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NME3 35
  • 99.01 (n)
  • 99.37 (a)
NME3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NME3 35
  • 90.93 (n)
  • 94.67 (a)
NME3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NME3 35
  • 86.88 (n)
  • 87.1 (a)
NME3 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nme3 35
  • 82.64 (n)
  • 88.76 (a)
Nme3 16
Nme3 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NME3 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nme3 35
  • 83.04 (n)
  • 90.53 (a)
chicken
(Gallus gallus)
Aves NME3 36
  • 67 (a)
OneToOne
NME4 35
  • 77.48 (n)
  • 78.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33976 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nme3 35
  • 71.4 (n)
  • 72.19 (a)
Str.10886 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10233 35
zebrafish
(Danio rerio)
Actinopterygii ndpkz3 35
nme3 35
  • 68.06 (n)
  • 73.21 (a)
nme3 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta awd 36
  • 60 (a)
OneToMany
awd 37
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea ndk-1 36
  • 56 (a)
OneToMany
F25H2.5 37
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 36
  • 58 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NDPK2 35
  • 52.48 (n)
  • 52.7 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.704 35
rice
(Oryza sativa)
Liliopsida Os12g0548300 35
  • 56.53 (n)
  • 54.73 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2227 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToMany
Species with no ortholog for NME3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NME3 Gene

ENSEMBL:
Gene Tree for NME3 (if available)
TreeFam:
Gene Tree for NME3 (if available)

Paralogs for NME3 Gene

Paralogs for NME3 Gene

Selected SIMAP similar genes for NME3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NME3: view

Variants for NME3 Gene

Sequence variations from dbSNP and Humsavar for NME3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs11890 -- 1,770,991(-) CAGGT(A/T)TGGCA reference, synonymous-codon
rs1131373 -- 1,771,171(-) TGCAG(G/T)CCTCC reference, missense
rs11543214 -- 1,770,952(-) GCGCT(A/C)ATCGG synonymous-codon, reference
rs12447827 -- 1,771,192(+) GCCGC(A/C)TGCGC intron-variant
rs113812579 -- 1,771,106(+) TTGAC(A/C/G)AGGCG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for NME3 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904954 CNV Loss 21882294
nsv905017 CNV Loss 21882294
nsv518641 CNV Loss 19592680
nsv457335 CNV Loss 19166990
dgv2538n71 CNV Loss 21882294
nsv517196 CNV Gain+Loss 19592680
nsv905023 CNV Gain 21882294
dgv2539n71 CNV Loss 21882294
dgv2540n71 CNV Loss 21882294
nsv457336 CNV Loss 19166990
nsv905030 CNV Loss 21882294
nsv471069 CNV Loss 18288195
dgv2541n71 CNV Loss 21882294
nsv905031 CNV Gain+Loss 21882294
dgv2542n71 CNV Loss 21882294
nsv905034 CNV Loss 21882294
nsv827500 CNV Gain 20364138
dgv2543n71 CNV Loss 21882294
nsv905039 CNV Loss 21882294

Relevant External Links for NME3 Gene

HapMap Linkage Disequilibrium report
NME3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NME3 Gene

Disorders for NME3 Gene

Relevant External Links for NME3

Genetic Association Database (GAD)
NME3
Human Genome Epidemiology (HuGE) Navigator
NME3
genes like me logo Genes that share disorders with NME3: view

No data available for UniProtKB/Swiss-Prot for NME3 Gene

Publications for NME3 Gene

  1. Structural and catalytic properties and homology modelling of the human nucleoside diphosphate kinase C, product of the DRnm23 gene. (PMID: 11277919) Erent M. … Lascu I. (Eur. J. Biochem. 2001) 3 23
  2. Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells. (PMID: 7638209) Venturelli D. … Calabretta B. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4
  3. Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family. (PMID: 9067290) Martinez R. … Calabretta B. (Cancer Res. 1997) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T. … Bobe J. (BMC Evol. Biol. 2009) 2 3

Products for NME3 Gene

  • Addgene plasmids for NME3

Sources for NME3 Gene

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