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Aliases for NME2P1 Gene

Aliases for NME2P1 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 2 Pseudogene 1 2 3
  • EC 2.7.4.6 4 64
  • Non-Metastatic Cells 2, Protein (NM23B) Expressed In, Pseudogene 1 2
  • NDP Kinase 4
  • NDK 4

External Ids for NME2P1 Gene

Summaries for NME2P1 Gene

GeneCards Summary for NME2P1 Gene

NME2P1 (NME/NM23 Nucleoside Diphosphate Kinase 2 Pseudogene 1) is a Pseudogene. Among its related pathways are purine nucleotide salvage and purine nucleotide salvage. GO annotations related to this gene include nucleoside diphosphate kinase activity.

UniProtKB/Swiss-Prot for NME2P1 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME2P1 Gene

Genomics for NME2P1 Gene

Genomic Location for NME2P1 Gene

Start:
120,282,218 bp from pter
End:
120,282,865 bp from pter
Size:
648 bases
Orientation:
Plus strand

Genomic View for NME2P1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NME2P1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME2P1 Gene

Regulatory Elements for NME2P1 Gene

Proteins for NME2P1 Gene

  • Protein details for NME2P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60361-NDK8_HUMAN
    Recommended name:
    Putative nucleoside diphosphate kinase
    Protein Accession:
    O60361
    Secondary Accessions:

    Protein attributes for NME2P1 Gene

    Size:
    137 amino acids
    Molecular mass:
    15529 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NME2P1 Gene

Proteomics data for NME2P1 Gene at MOPED

Selected DME Specific Peptides for NME2P1 Gene

Post-translational modifications for NME2P1 Gene

No Post-translational modifications

Domains for NME2P1 Gene

Protein Domains for NME2P1 Gene

UniProtKB/Swiss-Prot:

NDK8_HUMAN
Family:
  • Belongs to the NDK family.:
    • O60361
genes like me logo Genes that share domains with NME2P1: view

No data available for Gene Families for NME2P1 Gene

Function for NME2P1 Gene

Molecular function for NME2P1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

Enzyme Numbers (IUBMB) for NME2P1 Gene

Gene Ontology (GO) - Molecular Function for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NME2P1: view

Phenotypes for NME2P1 Gene

GenomeRNAi human phenotypes for NME2P1:
genes like me logo Genes that share phenotypes with NME2P1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NME2P1 Gene

Localization for NME2P1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NME2P1 Gene COMPARTMENTS Subcellular localization image for NME2P1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with NME2P1: view

Pathways for NME2P1 Gene

genes like me logo Genes that share pathways with NME2P1: view

Interacting Proteins for NME2P1 Gene

Gene Ontology (GO) - Biological Process for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
genes like me logo Genes that share ontologies with NME2P1: view

Compounds for NME2P1 Gene

(9) HMDB Compounds for NME2P1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
CDP
  • CDP
63-38-7
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)
65-47-4
dTDP
  • Deoxy-tdp
491-97-4
genes like me logo Genes that share compounds with NME2P1: view

Transcripts for NME2P1 Gene

mRNA/cDNA for NME2P1 Gene

(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NME2P1 Gene

No ASD Table

Relevant External Links for NME2P1 Gene

GeneLoc Exon Structure for
NME2P1
ECgene alternative splicing isoforms for
NME2P1

Expression for NME2P1 Gene

mRNA expression in normal human tissues for NME2P1 Gene

mRNA differential expression in normal tissues according to GTEx for NME2P1 Gene

This gene is overexpressed in Pancreas (6.3) and Testis (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NME2P1 Gene

genes like me logo Genes that share expressions with NME2P1: view

Orthologs for NME2P1 Gene

Evolution for NME2P1 Gene

ENSEMBL:
Gene Tree for NME2P1 (if available)
TreeFam:
Gene Tree for NME2P1 (if available)

No data available for Orthologs for NME2P1 Gene

Paralogs for NME2P1 Gene

Selected SIMAP similar genes for NME2P1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NME2P1: view

No data available for Paralogs for NME2P1 Gene

Variants for NME2P1 Gene

Relevant External Links for NME2P1 Gene

HapMap Linkage Disequilibrium report
NME2P1

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for NME2P1 Gene

Disorders for NME2P1 Gene

No disorders were found for NME2P1 Gene.

No data available for UniProtKB/Swiss-Prot for NME2P1 Gene

Publications for NME2P1 Gene

  1. Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396. (PMID: 7488060) Seifert M. … Welter C. (Biochem. Biophys. Res. Commun. 1995) 3
  2. Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. (PMID: 8270257) Dooley S. … Welter C. (Hum. Genet. 1994) 3
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. PKCI/ promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. (PMID: 22304920) Lau E. … Ronai Z.A. (Cell 2012) 3

Products for NME2P1 Gene

Sources for NME2P1 Gene

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