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Aliases for NME2P1 Gene

Aliases for NME2P1 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 2 Pseudogene 1 2 3 5
  • EC 2.7.4.6 4 63
  • Non-Metastatic Cells 2, Protein (NM23B) Expressed In, Pseudogene 1 2
  • NDP Kinase 4
  • NDK 4

External Ids for NME2P1 Gene

Previous GeneCards Identifiers for NME2P1 Gene

  • GC12P119131
  • GC12P119182
  • GC12P120719
  • GC12P117728

Summaries for NME2P1 Gene

GeneCards Summary for NME2P1 Gene

NME2P1 (NME/NM23 Nucleoside Diphosphate Kinase 2 Pseudogene 1) is a Pseudogene. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Pyrimidine metabolism (KEGG). GO annotations related to this gene include nucleoside diphosphate kinase activity.

UniProtKB/Swiss-Prot for NME2P1 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME2P1 Gene

Genomics for NME2P1 Gene

Regulatory Elements for NME2P1 Gene

Genomic Location for NME2P1 Gene

Chromosome:
12
Start:
120,282,253 bp from pter
End:
120,282,865 bp from pter
Size:
613 bases
Orientation:
Plus strand

Genomic View for NME2P1 Gene

Genes around NME2P1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME2P1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME2P1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME2P1 Gene

Proteins for NME2P1 Gene

  • Protein details for NME2P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60361-NDK8_HUMAN
    Recommended name:
    Putative nucleoside diphosphate kinase
    Protein Accession:
    O60361

    Protein attributes for NME2P1 Gene

    Size:
    137 amino acids
    Molecular mass:
    15529 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NME2P1 Gene

Proteomics data for NME2P1 Gene at MOPED

Selected DME Specific Peptides for NME2P1 Gene

Post-translational modifications for NME2P1 Gene

No Post-translational modifications

Domains & Families for NME2P1 Gene

Protein Domains for NME2P1 Gene

Suggested Antigen Peptide Sequences for NME2P1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60361

UniProtKB/Swiss-Prot:

NDK8_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME2P1: view

No data available for Gene Families for NME2P1 Gene

Function for NME2P1 Gene

Molecular function for NME2P1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

Enzyme Numbers (IUBMB) for NME2P1 Gene

Gene Ontology (GO) - Molecular Function for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NME2P1: view

Phenotypes for NME2P1 Gene

GenomeRNAi human phenotypes for NME2P1:
genes like me logo Genes that share phenotypes with NME2P1: view

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NME2P1 Gene

Localization for NME2P1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NME2P1 Gene

Pathways & Interactions for NME2P1 Gene

genes like me logo Genes that share pathways with NME2P1: view

Interacting Proteins for NME2P1 Gene

Gene Ontology (GO) - Biological Process for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006163 purine nucleotide metabolic process IBA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006220 pyrimidine nucleotide metabolic process IBA --
GO:0006228 UTP biosynthetic process IEA --
GO:0009142 nucleoside triphosphate biosynthetic process IBA --
genes like me logo Genes that share ontologies with NME2P1: view

No data available for SIGNOR curated interactions for NME2P1 Gene

Drugs & Compounds for NME2P1 Gene

(6) Drugs for NME2P1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for NME2P1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dTDP
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
491-97-4
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2
genes like me logo Genes that share compounds with NME2P1: view

Transcripts for NME2P1 Gene

mRNA/cDNA for NME2P1 Gene

(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NME2P1 Gene

No ASD Table

Relevant External Links for NME2P1 Gene

GeneLoc Exon Structure for
NME2P1
ECgene alternative splicing isoforms for
NME2P1

Expression for NME2P1 Gene

mRNA expression in normal human tissues for NME2P1 Gene

mRNA differential expression in normal tissues according to GTEx for NME2P1 Gene

This gene is overexpressed in Pancreas (x6.3) and Testis (x5.2).

Protein differential expression in normal tissues from HIPED for NME2P1 Gene

This gene is overexpressed in Nasal epithelium (14.1), Peripheral blood mononuclear cells (8.3), Tlymphocyte (8.3), Monocytes (7.8), Brain (6.3), and Cervix (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NME2P1 Gene



genes like me logo Genes that share expression patterns with NME2P1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NME2P1 Gene

Orthologs for NME2P1 Gene

Evolution for NME2P1 Gene

ENSEMBL:
Gene Tree for NME2P1 (if available)
TreeFam:
Gene Tree for NME2P1 (if available)

No data available for Orthologs for NME2P1 Gene

Paralogs for NME2P1 Gene

(8) SIMAP similar genes for NME2P1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NME2P1: view

No data available for Paralogs for NME2P1 Gene

Variants for NME2P1 Gene

Relevant External Links for NME2P1 Gene

HapMap Linkage Disequilibrium report
NME2P1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for NME2P1 Gene

Disorders for NME2P1 Gene

No disorders were found for NME2P1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for NME2P1 Gene

Publications for NME2P1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  3. PKCI/ promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. (PMID: 22304920) Lau E. … Ronai Z.A. (Cell 2012) 3
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396. (PMID: 7488060) Seifert M. … Welter C. (Biochem. Biophys. Res. Commun. 1995) 3

Products for NME2P1 Gene

Sources for NME2P1 Gene

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