NME2P1 Gene
pseudogene GIFtS: 30
GCID: GC12P120719
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NME/NM23 nucleoside diphosphate kinase 2 pseudogene 1(Previous names: non-metastatic cells 2, protein (NM23B) expressed in, pseudogene...)
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Aliases
for NME2P1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| NME/NM23 Nucleoside Diphosphate Kinase 2 Pseudogene 11 2 | | EC 2.7.4.63 8 | | Non-Metastatic Cells 2, Protein (NM23B) Expressed In, Pseudogene 11 | | NDK3 | | NDP Kinase3 |
| External Ids: | HGNC: 313581 | Entrez Gene: 2834582 | Ensembl: ENSG000001230097 | UniProtKB: O603613 | | ORGUL members: | |
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| NONCODE:n381942 | |
Export aliases for NME2P1 gene to outside databasesPrevious GC identifers: GC12P119131 GC12P119182 GC12P117728
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Summaries
for NME2P1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NDK8_HUMAN, O60361Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate istransferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (Bysimilarity)
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Genomic Views
for NME2P1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NME2P1 gene promoter:
E2F-4 E2F-3a E2F-5 AP-1 ATF-2 E2F-2 E2F E2F-1 STAT3 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for NME2P1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NME2P1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31NME2P1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P120719: view genomic region
(about GC identifiers)
Start:
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120,719,940 bp from pter |
End:
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120,720,632 bp from pter |
Size:
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693 bases |
Orientation:
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plus strand |
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Proteins
for NME2P1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: NDK8_HUMAN, O60361 (See
protein sequence)Recommended Name: Putative nucleoside diphosphate kinase Size: 137 amino acids; 15529 Da
Cofactor: Magnesium (By similarity)
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for NME2P1: NX_O60361
4/9 DME Specific Peptides for NME2P1 (O60361) (see all 9)
NME2P1 Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
NME2P1 Antibody Products:
Assay Products for NME2P1: |
Protein
Domains /
Families
for NME2P1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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NME2P1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60361ProtoNet protein and cluster: O60361 1 Blocks protein family: IPB001564 Nucleoside diphosphate kinase
UniProtKB/Swiss-Prot: NDK8_HUMAN, O60361Similarity: Belongs to the NDK family |
Function
for NME2P1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: NDK8_HUMAN, O60361Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate istransferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (Bysimilarity)Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphateEnzyme Number (IUBMB): EC 2.7.4.61 2
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0004550 | nucleoside diphosphate kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
NME2P1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NME2P1:
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Pathways & Interactions
for NME2P1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | pyrimidine ribonucleotides interconversion | | | 2 | ATP/ITP metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  EMD Millipore Pathway for NME2P1
1  GeneGo (Thomson Reuters) Pathway for NME2P1
4  BioSystems Pathways for NME2P1
NME2P1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NME2P1
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006183 | GTP biosynthetic process |
IEA | -- | | GO:0006228 | UTP biosynthetic process |
IEA | -- | | GO:0006241 | CTP biosynthetic process |
IEA | -- |
NME2P1 for ontologies About GeneDecksing
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Drugs & Compounds
for NME2P1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for NME2P1
9 HMDB Compounds for NME2P1 About this table
Search CenterWatch for drugs/clinical trials and news about NME2P1
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Transcripts
for NME2P1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000426182 ENST00000242630
10 AceView cDNA sequences: NR_001577 CB994624 BG573489 CB992393 AA654317 R74592 R74485 AA446261 R28079 CB993665
GeneLoc Exon Structure
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Expression
for NME2P1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NME2P1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NME2P1 Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for NME2P1
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NME2P1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NME2P1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NME2P1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NME2P1 |
Orthologs
for NME2P1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for NME2P1 (if available)
TreeFam Gene Tree for NME2P1 (if available) |
Paralogs
for NME2P1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for NME2P1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for NME2P1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for NME2P1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for NME2P1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NME2P1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396. (PubMed id 7488060)1 Seifert M.... Welter C. (1995)
- Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. (PubMed id 8270257)1 Dooley S.... Welter C. (1994)
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External Searches for NME2P1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NME2P1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing NME2P1 gene
(According to HUGE)
About This Section
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Specialized Databases showing NME2P1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for NME2P1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for NME2P1 gene:
Search GeneIP for patents involving NME2P1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NME2P1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NME2P1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NME2P1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NME2P1 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NME2P1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NME2P1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NME2P1 |
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| | | | Search Tocris compounds for NME2P1 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for NME2P1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NME2P1 |
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GeneCards Homepage -
Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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