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NME2P1 Gene

pseudogene   GIFtS: 29
GCID: GC12P120719

NME/NM23 Nucleoside Diphosphate Kinase 2 Pseudogene 1

(Previous names: non-metastatic cells 2, protein (NM23B) expressed in, pseudogene...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NME/NM23 Nucleoside Diphosphate Kinase 2 Pseudogene 11 2
EC 2.7.4.63 8
Non-Metastatic Cells 2, Protein (NM23B) Expressed In, Pseudogene 11
NDK3
NDP Kinase3

External Ids:    HGNC: 313581   Entrez Gene: 2834582   Ensembl: ENSG000001230097   UniProtKB: O603613   

Export aliases for NME2P1 gene to outside databases

Previous GC identifers: GC12P119131 GC12P119182 GC12P117728


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NME2P1 Gene:
NME2P1 (NME/NM23 nucleoside diphosphate kinase 2 pseudogene 1) is a pseudogene. GO annotations related to this gene include nucleoside diphosphate kinase activity.

UniProtKB/Swiss-Prot: NDK8_HUMAN, O60361
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is
transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NME2P1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   ATF-2   E2F-2   E2F   E2F-1   STAT3   c-Jun   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME2P1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

NME2P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME2P1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P120719:  view genomic region     (about GC identifiers)

Start:
120,719,940 bp from pter      End:
120,720,668 bp from pter
Size:
729 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NDK8_HUMAN, O60361 (See protein sequence)
Recommended Name: Putative nucleoside diphosphate kinase  
Size: 137 amino acids; 15529 Da
Cofactor: Magnesium (By similarity)
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for NME2P1: NX_O60361

Explore proteomics data for NME2P1 at MOPED

Selected DME Specific Peptides for NME2P1 (O60361) (see all 9)
 PGTIRGD  RFEQKGF  PFFPGLV  NIIHGSD 


See NME2P1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR023005 Nucleoside_diP_kinase_AS
 IPR001564 Nucleoside_diP_kinase

Graphical View of Domain Structure for InterPro Entry O60361

ProtoNet protein and cluster: O60361

1 Blocks protein domain: IPB001564 Nucleoside diphosphate kinase

UniProtKB/Swiss-Prot: NDK8_HUMAN, O60361
Similarity: Belongs to the NDK family


Find genes that share domains with NME2P1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NDK8_HUMAN, O60361
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is
transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
(By similarity)
Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

     Enzyme Number (IUBMB): EC 2.7.4.61 2

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004550nucleoside diphosphate kinase activity IEA--
GO:0005524ATP binding IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with NME2P1           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for NME2P1:
 Decreased Salmonella enterica  

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus2
extracellular1
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NME2P1 About    
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Purine metabolism (KEGG)
ATP ITP metabolism0.31
purine deoxyribonucleosides salvage0.00
2superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
adenosine deoxyribonucleotides de novo biosynthesis0.00
guanosine deoxyribonucleotides de novo biosynthesis0.52
pyrimidine deoxyribonucleotides de novo biosynthesis0.00
superpathway of pyrimidine deoxyribonucleoside salvage0.46
UTP and CTP de novo biosynthesis0.00
CMP phosphorylation0.00
superpathway of pyrimidine ribonucleotides de novo biosynthesis0.00
3purine nucleotide salvage
purine nucleotide salvage0.78
guanosine nucleotides de novo biosynthesis0.00
purine nucleotides de novo biosynthesis0.78
guanosine ribonucleotides de novo biosynthesis0.00

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for NME2P1
    ATP/ITP metabolism

Selected BioSystems Pathways for NME2P1 (see all 15)
    purine nucleotides de novo biosynthesis
superpathway of pyrimidine ribonucleotides de novo biosynthesis
purine deoxyribonucleosides salvage
guanosine nucleotides de novo biosynthesis
purine nucleotide salvage


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Interactions:

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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006183GTP biosynthetic process IEA--
GO:0006228UTP biosynthetic process IEA--
GO:0006241CTP biosynthetic process IEA--

Find genes that share ontologies with NME2P1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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9 HMDB Compounds for NME2P1    About this table
CompoundSynonyms CAS #PubMed Ids
ADPadenosindiphosphorsaeure (see all 8)58-64-0--
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
CDPCDP (see all 3)63-38-7--
Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
Guanosine diphosphate5'-GDP (see all 10)146-91-8--
Guanosine triphosphate5'-GTP (see all 10)86-01-1--
MagnesiumMagnesium (see all 2)7439-95-4--
Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--
dTDPDeoxy-tdp (see all 5)491-97-4--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000426182 ENST00000242630
miRNA
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10 AceView cDNA sequences:

NR_001577 CB994624 BG573489 CB992393 R74592 AA654317 AA446261 R74485 
CB993665 R28079 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NME2P1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
NME2P1 Expression
About this image

NME2P1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NME2P1 Protein Expression
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for NME2P1 (if available)
TreeFam Gene Tree for NME2P1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NME2P1 gene
8 SIMAP similar genes for NME2P1 using alignment to 1 protein entry:     NDK8_HUMAN:
NME1-NME2    NME2    NME1    NME3    c371H6.2    NME4
NME6    NME7

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing NME2P1
DNA2.0 Custom Variant and Variant Library Synthesis for NME2P1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NME2P1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with NME2P1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
  2. PKCI/ promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. (PubMed id 22304920)1 Lau E....Ronai Z.A. (Cell 2012)
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  4. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
  5. Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396. (PubMed id 7488060)1 Seifert M.... Welter C. (Biochem. Biophys. Res. Commun. 1995)
  6. Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. (PubMed id 8270257)1 Dooley S.... Welter C. (Hum. Genet. 1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 283458 HGNC: 31358 AceView: NME2P1 Ensembl:ENSG00000123009 euGenes: HUgn283458
ECgene: NME2P1 H-InvDB: NME2P1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NME2P1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NME2P1 gene:
Search GeneIP for patents involving NME2P1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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