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Aliases for NME2 Gene

Aliases for NME2 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 2 2 3 5
  • Non-Metastatic Cells 2, Protein (NM23B) Expressed In 2 3
  • C-Myc Purine-Binding Transcription Factor PUF 3 4
  • Histidine Protein Kinase NDKB 3 4
  • NDP Kinase B 3 4
  • EC 2.7.4.6 4 63
  • Nm23-H2 3 4
  • NM23B 3 4
  • Epididymis Secretory Sperm Binding Protein Li 155an 3
  • Non-Metastatic Cells 2, Protein (NM23) Expressed In 3
  • Nucleotide Diphosphate Kinase B 3
  • C-Myc Transcription Factor 3
  • HEL-S-155an 3
  • EC 2.7.13.3 4
  • NDPK-B 3
  • NDK B 4
  • NDPKB 3
  • NDKB 3
  • PUF 3

External Ids for NME2 Gene

Previous GeneCards Identifiers for NME2 Gene

  • GC17U990063
  • GC17P051725
  • GC17P049584
  • GC17P049718
  • GC17P046598
  • GC17P049242
  • GC17P044612

Summaries for NME2 Gene

Entrez Gene Summary for NME2 Gene

  • Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]

GeneCards Summary for NME2 Gene

NME2 (NME/NM23 Nucleoside Diphosphate Kinase 2) is a Protein Coding gene. Diseases associated with NME2 include Bladder Disease and Myxosarcoma. Among its related pathways are Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics and Pyrimidine metabolism (KEGG). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enzyme binding. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME2 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

Gene Wiki entry for NME2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME2 Gene

Genomics for NME2 Gene

Regulatory Elements for NME2 Gene

Enhancers for NME2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NME2 on UCSC Golden Path with GeneCards custom track

Promoters for NME2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NME2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NME2 gene promoter:

Genomic Location for NME2 Gene

Chromosome:
17
Start:
51,165,435 bp from pter
End:
51,171,747 bp from pter
Size:
6,313 bases
Orientation:
Plus strand

Genomic View for NME2 Gene

Genes around NME2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME2 Gene

Proteins for NME2 Gene

  • Protein details for NME2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22392-NDKB_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase B
    Protein Accession:
    P22392
    Secondary Accessions:
    • A8MWA3
    • Q1WM23
    • Q6LCT6

    Protein attributes for NME2 Gene

    Size:
    152 amino acids
    Molecular mass:
    17298 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8 (By similarity). Interacts with AKAP13. Interacts ITGB1BP1 (via C-terminal domain region).
    • Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8 (By similarity). Interacts with AKAP13. Interacts ITGB1BP1 (via C-terminal domain region).

    Three dimensional structures from OCA and Proteopedia for NME2 Gene

    Alternative splice isoforms for NME2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NME2 Gene

Proteomics data for NME2 Gene at MOPED

Post-translational modifications for NME2 Gene

  • Ubiquitination at Lys 39
  • Modification sites at PhosphoSitePlus

Domains & Families for NME2 Gene

Gene Families for NME2 Gene

Protein Domains for NME2 Gene

Suggested Antigen Peptide Sequences for NME2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22392

UniProtKB/Swiss-Prot:

NDKB_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME2: view

Function for NME2 Gene

Molecular function for NME2 Gene

GENATLAS Biochemistry:
non-metastatic cells 2,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of nucleoside diphosphates and acting as a transcription regulator for myc,pyrimidine biosynthetic pathway
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

Enzyme Numbers (IUBMB) for NME2 Gene

Gene Ontology (GO) - Molecular Function for NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 11919189
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NME2: view
genes like me logo Genes that share phenotypes with NME2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NME2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NME2 Gene

Localization for NME2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NME2 Gene

Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 3 is mainly cytoplasmic and isoform 1 and isoform 3 are excluded from the nucleolus. Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. {ECO:0000269 PubMed:11919189, ECO:0000269 PubMed:16442775}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NME2 Gene COMPARTMENTS Subcellular localization image for NME2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 2
mitochondrion 2
plasma membrane 2
chloroplast 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15703214
GO:0005882 intermediate filament IEA --
GO:0031966 mitochondrial membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with NME2: view

Pathways & Interactions for NME2 Gene

genes like me logo Genes that share pathways with NME2: view

SIGNOR curated interactions for NME2 Gene

Activates:

Gene Ontology (GO) - Biological Process for NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006163 purine nucleotide metabolic process IBA --
GO:0006220 pyrimidine nucleotide metabolic process IBA --
GO:0006241 CTP biosynthetic process IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 8392752
GO:0007229 integrin-mediated signaling pathway IDA 11919189
genes like me logo Genes that share ontologies with NME2: view

Drugs & Compounds for NME2 Gene

(19) Drugs for NME2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adefovir Dipivoxil Approved, Investigational Pharma Enzyme, substrate 131
Lamivudine Approved, Investigational Pharma Enzyme, substrate Nucleoside analog reverse transcriptase inhibitor 601
Tenofovir Approved, Investigational Pharma Enzyme, substrate HIV reverse transcriptase inhibitor 701
Adenosine triphosphate Approved Nutra 0
Guanosine diphosphate Experimental Pharma Target 0

(16) Additional Compounds for NME2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxy-Inosine 5'-(tetrahydrogen triphosphate)
  • 2'-Deoxyinosine-5'-triphosphate
  • 2'-Ditp
  • Deoxyinosine 5'-triphosphate
  • Deoxyinosine triphosphate
16595-02-1
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
1173-82-6
genes like me logo Genes that share compounds with NME2: view

Transcripts for NME2 Gene

Unigene Clusters for NME2 Gene

NME/NM23 nucleoside diphosphate kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NME2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - -
SP7:

Relevant External Links for NME2 Gene

GeneLoc Exon Structure for
NME2
ECgene alternative splicing isoforms for
NME2

Expression for NME2 Gene

mRNA expression in normal human tissues for NME2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NME2 Gene



SOURCE GeneReport for Unigene cluster for NME2 Gene Hs.463456

mRNA Expression by UniProt/SwissProt for NME2 Gene

P22392-NDKB_HUMAN
Tissue specificity: Isoform 1 and isoform 3 are ubiquitously expressed.
genes like me logo Genes that share expression patterns with NME2: view

Protein tissue co-expression partners for NME2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for NME2 Gene

Orthologs for NME2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NME2 35
  • 91.45 (n)
  • 93.42 (a)
NME2 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NME2 35
  • 91.67 (n)
  • 92.11 (a)
mouse
(Mus musculus)
Mammalia Nme2 35
  • 90.35 (n)
  • 98.03 (a)
Nme2 16
Gm20390 36
  • 97 (a)
ManyToMany
Gm4862 36
  • 73 (a)
ManyToMany
Nme2 36
  • 97 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Nme2 35
  • 91.23 (n)
  • 98.03 (a)
oppossum
(Monodelphis domestica)
Mammalia NME2 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NME2 36
  • 86 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
OneToMany
chicken
(Gallus gallus)
Aves NME2 35
  • 83.89 (n)
  • 92.72 (a)
NME1 36
  • 81 (a)
ManyToMany
NME2 36
  • 92 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nme2 35
  • 77.7 (n)
  • 86.09 (a)
Str.5826 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
nme2b.2 35
  • 75.45 (n)
  • 79.73 (a)
CABZ01038708.1 36
  • 61 (a)
ManyToMany
nme2a 36
  • 68 (a)
ManyToMany
nme2b.2 36
  • 78 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta awd 37
  • 77 (a)
awd 36
  • 68 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F25H2.5 37
  • 68 (a)
ndk-1 36
  • 68 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 36
  • 60 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5246 35
rice
(Oryza sativa)
Liliopsida Os.146 35
Os07g0492000 35
  • 63.74 (n)
  • 60.81 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.4748 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToMany
Species with no ortholog for NME2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NME2 Gene

ENSEMBL:
Gene Tree for NME2 (if available)
TreeFam:
Gene Tree for NME2 (if available)

Paralogs for NME2 Gene

Paralogs for NME2 Gene

(8) SIMAP similar genes for NME2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NME2 Gene

genes like me logo Genes that share paralogs with NME2: view

Variants for NME2 Gene

Variation tolerance for NME2 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NME2 Gene

Disorders for NME2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NME2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bladder disease
  • urinary bladder disease
myxosarcoma
radiation cystitis
  • irradiation cystitis
lung sarcoma
  • pulmonary sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search NME2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NME2

Genetic Association Database (GAD)
NME2
Human Genome Epidemiology (HuGE) Navigator
NME2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NME2
genes like me logo Genes that share disorders with NME2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NME2 Gene

Publications for NME2 Gene

  1. Identification of a second human nm23 gene, nm23-H2. (PMID: 1988104) Stahl J.A. … King C.R. (Cancer Res. 1991) 2 3 4 67
  2. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T. … Bobe J. (BMC Evol. Biol. 2009) 2 3
  3. Structure-based mutational and functional analysis identify human NM23-H2 as a multifunctional enzyme. (PMID: 12009894) Postel E.H. … Xu Y. (Biochemistry 2002) 3 23
  4. Cytoskeletal association of the A and B nucleoside diphosphate kinases of interphasic but not mitotic human carcinoma cell lines: specific nuclear localization of the B subunit. (PMID: 9925751) Pinon V.P. … Lacombe M.L. (Exp. Cell Res. 1999) 3 23
  5. The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma. (PMID: 7768941) Ji L. … Boxer L.M. (J. Biol. Chem. 1995) 3 23

Products for NME2 Gene

Sources for NME2 Gene

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