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Aliases for NME2 Gene

Aliases for NME2 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 2 2 3
  • Non-Metastatic Cells 2, Protein (NM23B) Expressed In 2 3
  • C-Myc Purine-Binding Transcription Factor PUF 3 4
  • Histidine Protein Kinase NDKB 3 4
  • NDP Kinase B 3 4
  • EC 2.7.4.6 4 63
  • NM23-H2 3 4
  • NM23B 3 4
  • Epididymis Secretory Sperm Binding Protein Li 155an 3
  • Non-Metastatic Cells 2, Protein (NM23) Expressed In 3
  • Nucleoside Diphosphate Kinase B 3
  • Nucleotide Diphosphate Kinase B 3
  • C-Myc Transcription Factor 3
  • HEL-S-155an 3
  • EC 2.7.13.3 4
  • NDPK-B 3
  • NDPKB 3
  • NDK B 4
  • NDKB 3
  • PUF 3

External Ids for NME2 Gene

Previous GeneCards Identifiers for NME2 Gene

  • GC17U990063
  • GC17P051725
  • GC17P049584
  • GC17P049718
  • GC17P046598
  • GC17P049242
  • GC17P044612

Summaries for NME2 Gene

Entrez Gene Summary for NME2 Gene

  • Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]

GeneCards Summary for NME2 Gene

NME2 (NME/NM23 Nucleoside Diphosphate Kinase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein histidine kinase activity. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME2 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

Gene Wiki entry for NME2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME2 Gene

Genomics for NME2 Gene

Regulatory Elements for NME2 Gene

Transcription factor binding sites by QIAGEN in the NME2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NME2 Gene

Start:
51,153,590 bp from pter
End:
51,171,744 bp from pter
Size:
18,155 bases
Orientation:
Plus strand

Genomic View for NME2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NME2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME2 Gene

Proteins for NME2 Gene

  • Protein details for NME2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22392-NDKB_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase B
    Protein Accession:
    P22392
    Secondary Accessions:
    • A8MWA3
    • Q1WM23
    • Q6LCT6

    Protein attributes for NME2 Gene

    Size:
    152 amino acids
    Molecular mass:
    17298 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8 (By similarity). Interacts with AKAP13. Interacts ITGB1BP1 (via C-terminal domain region).

    Three dimensional structures from OCA and Proteopedia for NME2 Gene

    Alternative splice isoforms for NME2 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for NME2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    F6XY72
    Recommended name:
    HCG2001850, isoform CRA_c
    Protein Accession:
    F6XY72
    Secondary Accessions:

    Protein attributes for NME2 Gene

    Size:
    82 amino acids
    Molecular mass:
    9583 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NME2 Gene

Proteomics data for NME2 Gene at MOPED

Post-translational modifications for NME2 Gene

  • Ubiquitination at Lys39, Lys49, Lys56, Lys85, Lys124, Lys128, Lys49, and Lys56
  • Modification sites at PhosphoSitePlus

Other Protein References for NME2 Gene

Antibody Products

Domains for NME2 Gene

Protein Domains for NME2 Gene

Suggested Antigen Peptide Sequences for NME2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22392

UniProtKB/Swiss-Prot:

NDKB_HUMAN :
  • P22392
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME2: view

No data available for Gene Families for NME2 Gene

Function for NME2 Gene

Molecular function for NME2 Gene

GENATLAS Biochemistry: non-metastatic cells 2,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of nucleoside diphosphates and acting as a transcription regulator for myc,pyrimidine biosynthetic pathway
UniProtKB/Swiss-Prot CatalyticActivity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
UniProtKB/Swiss-Prot CatalyticActivity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
UniProtKB/Swiss-Prot Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

Enzyme Numbers (IUBMB) for NME2 Gene

Gene Ontology (GO) - Molecular Function for NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8392752
GO:0004550 nucleoside diphosphate kinase activity IDA 1851158
genes like me logo Genes that share ontologies with NME2: view
genes like me logo Genes that share phenotypes with NME2: view

Animal Models for NME2 Gene

MGI Knock Outs for NME2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NME2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for NME2 Gene

Localization for NME2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NME2 Gene

Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus. Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NME2 Gene COMPARTMENTS Subcellular localization image for NME2 gene
Compartment Confidence
nucleus 5
cytosol 4
chloroplast 2
cytoskeleton 2
mitochondrion 2
plasma membrane 2
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 11919189
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA 15703214
GO:0005739 mitochondrion IBA --
GO:0005813 centrosome --
genes like me logo Genes that share ontologies with NME2: view

Pathways for NME2 Gene

genes like me logo Genes that share pathways with NME2: view

Gene Ontology (GO) - Biological Process for NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002762 negative regulation of myeloid leukocyte differentiation --
GO:0006163 purine nucleotide metabolic process IBA --
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006220 pyrimidine nucleotide metabolic process IBA --
genes like me logo Genes that share ontologies with NME2: view

Compounds for NME2 Gene

(21) HMDB Compounds for NME2 Gene

Compound Synonyms Cas Number PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxyinosine-5'-triphosphate
16595-02-1
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
CDP
  • CDP
63-38-7
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)
65-47-4

(4) Drugbank Compounds for NME2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adefovir Dipivoxil
  • Adefovir
142340-99-6 enzyme substrate
Guanosine-5'-Diphosphate
146-91-8 target
Lamivudine
134678-17-4 enzyme substrate
Tenofovir
  • D,L-Tenofovir
147127-20-6 enzyme substrate

(9) Novoseek inferred chemical compound relationships for NME2 Gene

Compound -log(P) Hits PubMed IDs
gdp 24.3 3
phorbol 23.5 1
oligonucleotide 22.6 2
guanine 16.5 1
histidine 6.18 2
genes like me logo Genes that share compounds with NME2: view

Transcripts for NME2 Gene

Unigene Clusters for NME2 Gene

NME/NM23 nucleoside diphosphate kinase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NME2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - -
SP7:

Relevant External Links for NME2 Gene

GeneLoc Exon Structure for
NME2
ECgene alternative splicing isoforms for
NME2

Expression for NME2 Gene

mRNA expression in normal human tissues for NME2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NME2 Gene

SOURCE GeneReport for Unigene cluster for NME2 Gene Hs.463456

mRNA Expression by UniProt/SwissProt for NME2 Gene

P22392-NDKB_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with NME2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NME2 Gene

Orthologs for NME2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 92 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia NME2 35
  • 91.45 (n)
  • 93.42 (a)
NME2 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NME2 35
  • 91.67 (n)
  • 92.11 (a)
mouse
(Mus musculus)
Mammalia Gm20390 36
  • 97 (a)
ManyToMany
Nme2 35
  • 90.35 (n)
  • 98.03 (a)
Nme2 16
Nme2 36
  • 97 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia NME2 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NME2 36
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nme2 35
  • 91.23 (n)
  • 98.03 (a)
chicken
(Gallus gallus)
Aves NME1 36
  • 81 (a)
ManyToMany
NME2 35
  • 83.89 (n)
  • 92.72 (a)
NME2 36
  • 92 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nme2 35
  • 77.7 (n)
  • 86.09 (a)
Str.5826 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
CABZ01038708.1 36
  • 61 (a)
ManyToMany
nme2a 36
  • 68 (a)
ManyToMany
nme2b.2 35
  • 75.45 (n)
  • 79.73 (a)
nme2b.2 36
  • 78 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta awd 36
  • 68 (a)
OneToMany
awd 37
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea ndk-1 36
  • 68 (a)
OneToMany
F25H2.5 37
  • 68 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 36
  • 60 (a)
OneToMany
YNK1 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5246 35
rice
(Oryza sativa)
Liliopsida Os.146 35
Os07g0492000 35
  • 63.74 (n)
  • 60.81 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.4748 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToMany
Species with no ortholog for NME2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NME2 Gene

ENSEMBL:
Gene Tree for NME2 (if available)
TreeFam:
Gene Tree for NME2 (if available)

Paralogs for NME2 Gene

Paralogs for NME2 Gene

Selected SIMAP similar genes for NME2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NME2 Gene

genes like me logo Genes that share paralogs with NME2: view

Variants for NME2 Gene

Relevant External Links for NME2 Gene

HapMap Linkage Disequilibrium report
NME2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for NME2 Gene

Disorders for NME2 Gene

(1) University of Copenhagen DISEASES for NME2 Gene

(13) Novoseek inferred disease relationships for NME2 Gene

Disease -log(P) Hits PubMed IDs
burkitt lymphoma 42.2 2
cancer 29.8 6
tumors 25.9 8
metastasis 14.9 5
breast cancer 10.3 4

Relevant External Links for NME2

Genetic Association Database (GAD)
NME2
Human Genome Epidemiology (HuGE) Navigator
NME2
genes like me logo Genes that share disorders with NME2: view

No data available for UniProtKB/Swiss-Prot for NME2 Gene

Publications for NME2 Gene

  1. X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2-A resolution. (PMID: 8747457) Morera S. … Janin J. (Structure 1995) 3 4 23
  2. Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. (PMID: 8392752) Postel E.H. … Ferrone C.A. (Science 1993) 3 4 23
  3. Identification of a second human nm23 gene, nm23-H2. (PMID: 1988104) Stahl J.A. … King C.R. (Cancer Res. 1991) 2 3 4
  4. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T. … Bobe J. (BMC Evol. Biol. 2009) 2 3
  5. Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. (PMID: 11919189) Fournier H.N. … Albiges-Rizo C. (J. Biol. Chem. 2002) 3 4

Products for NME2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NME2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for NME2
  • Block miRNA regulation of NME2 using miScript Target Protectors
  • Addgene plasmids for NME2

Sources for NME2 Gene

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