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NME2 Gene

protein-coding GIFtS: 63

GC17P046598

non-metastatic cells 2, protein (NM23B) expressed in
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.4.6 ^³
MGC111212 ^²
NDPK-B ^²
NDPKB ^²
NM23-H2 ^¹, ²
NM23B ^², ³
OTTHUMP00000174727 ^²
OTTHUMP00000174728 ^²
OTTHUMP00000174774 ^²
OTTHUMP00000174775 ^²
OTTHUMP00000174776 ^²
nm23-H2 ^³
puf ^²

Descriptions
C-myc purine-binding transcription factor PUF ^³
NDK B ^³
NDP kinase B ^², ³
c-myc transcription factor ^²
non-metastatic cells 2, protein (NM23) expressed in ^²
non-metastatic cells 2, protein (NM23B) expressed in ^²
nucleoside diphosphate kinase B ^²

External Ids
HGNC: 7850¹
Entrez Gene: 4831²
UniProtKB: P22392³
Ensembl: ENSG00000011052⁷

Search outside databases for aliases for NME2 gene

Previous GC identifers: GC17U990063 GC17P051725 GC17P049584 GC17P049718

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NME2:

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1)

and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript

variants encoding the same isoform have been found for this gene. Co-transcription of this gene

and the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2)

which encode a fusion protein comprised of sequence sharing identity with each individual gene

product. [provided by RefSeq]

UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392

Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively

regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the

c-Myc gene; binds DNA non-specifically (PubMed:8392752)

Gene Wiki entry for NME2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NME2 gene

Entrez Gene cytogenetic band: 17q21.3 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21.33

NME2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P046598: (about GC identifiers)

Start:	46,585,919 bp from pter
End:	46,604,104 bp from pter
Size:	18,186 bases
Orientation:	plus strand

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392 (See protein sequence)

Recommended Name: Nucleoside diphosphate kinase B

Size: 152 amino acids; 17298 Da

Cofactor: Magnesium (By similarity)

Subunit: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts

with CAPN8 (By similarity). Interacts with AKAP13

Subcellular location: Cytoplasm. Nucleus. Note=Isoform 2 is mainly cytoplasmic and isoform 1 and

isoform 2 are excluded from the nucleolus

PDB structures from and Proteopedia :

1NSK (3D)

1NUE (3D)

3BBB (3D)

3BBC (3D)

3BBF (3D)

Secondary accessions: A8MWA3 Q1WM23 Q6LCT6

Alternative splicing: 2 isoforms: P22392-1 P22392-2

Post-translational modifications:

The N-terminus is blocked¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001018147.1 NP_001018148.1 NP_001018149.1 NP_002503.1

ENSEMBL proteins:

ENSP00000376895 ENSP00000376894 ENSP00000312446 ENSP00000337060 ENSP00000013034 ENSP00000365572

ENSP00000376892 ENSP00000376888 ENSP00000376890 ENSP00000376889 ENSP00000376887 ENSP00000376886

ENSP00000376880 ENSP00000376882

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NME2)
	Human Recombinant Proteins from Abnova (NME2)

OriGene Purified Recombinant Human Proteins (see all 2): NME2

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IDA	11919189
GO:0005634	nucleus	NAS	--
GO:0005737	cytoplasm	IEA	--
GO:0030027	lamellipodium	IDA	11919189

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Antibodies for NME2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NME2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (NME2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NME2)
	Novus Biologicals Antibodies for NME2

Assays for NME2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P22392

ProtoNet protein and cluster: P22392

1 Blocks protein family: IPB001564 Nucleoside diphosphate kinase

UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392

Similarity: Belongs to the NDK family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NME2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NME2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_002512

Applied Biosystems Silencer® siRNAs for NME2

Sigma-Aldrich siRNA for NME2

Sigma-Aldrich shRNA Panels and shRNA for NME2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NME2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001018137
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001018137
untagged cDNA clones in CMV expression vector (see all 4): NM_001018137

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001018139

UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392

Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively

regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the

c-Myc gene; binds DNA non-specifically (PubMed:8392752)

Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

Enzyme Number (IUBMB): EC 2.7.4.6

Genatlas biochemistry entry for NME2:

non-metastatic cells 2,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in

the phosphorylation of nucleoside diphosphates and acting as a transcription regulator for

myc,pyrimidine biosynthetic pathway

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nme2):

embryogenesis	growth/size	hematopoietic system	homeostasis/metabolism	lethality-prenatal/perinatal
skin/coat/nails

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0003700	transcription factor activity	TAS	8392752
GO:0004550	nucleoside diphosphate kinase activity	TAS	--
GO:0005515	protein binding	IPI	11919189 17314099 17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for NME2 (Your Favorite Gene powered by Ingenuity)

Purine Metabolism
Pyrimidine Metabolism

GeneDecks NME2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for NME2

5/86 Interacting proteins for NME2 (ENSP00000365572³ P22392^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 86 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NME3	Q13232²	STRING (score=.882) MINT-64130
-	P01616¹	EBI-713693, EBI-1054063 EBI-713693, EBI-1053880
ACLY	P53396¹	EBI-713693, EBI-1042794
ATIC	P31939¹	EBI-713693, EBI-1048599
DYNC1H1	Q14204¹	EBI-713693, EBI-356015

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5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006183	GTP biosynthetic process	IEA	--
GO:0006228	UTP biosynthetic process	IEA	--
GO:0006241	CTP biosynthetic process	IEA	--
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	TAS	8392752

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NME2
6 Novoseek chemical compound relationships for NME2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gdp	26.75	3	8747457 (2), 18084788 (1)
phorbol	25.30	1	11668637 (1)
oligonucleotide	25.03	2	8314536 (1), 7479028 (1)
histidine	8.85	2	17157250 (2)
atp	0.00	1	7479028 (1)
glucose	0.00	1	11727934 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NME2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NME2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_002512

Sigma-Aldrich siRNA for NME2

Sigma-Aldrich shRNA Panels and shRNA for NME2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001018137 NM_001018138 NM_001018139 NM_002512

REFSEQ mRNAs for NME2 gene (4 alternative transcripts):

NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001018137 NM_001018138 NM_001018139 NM_002512

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001018137
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001018137
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001018137

24/233 AceView cDNA sequences (see all 233 ):

BQ678803 X17620 CB163460 BI858006 CB108710 AA373087 BM765413 BM552890

BU165414 CD109158 BE905337 BE784067 AU098718 BQ925648 AA368995 NM_000269

BG033447 CA449399 BQ435141 AI708633 BM846125 BU615517 AW768951 BM554149

highest scoring ESTs for NME2:

BF229291 F24128 X58965 F22253 AA761011 AW273877 BG164775 BM990296 BQ231394 F33510

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NME2 (see all 7 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c
SP1:							-		-								-				-				-
SP2:							-		-		-						-				-				-
SP3:							-		-		-						-								-
SP4:									-								-				-
SP5:							-		-		-						-				-

About this scheme

ECgene alternative splicing isoforms for NME2

14 Ensembl transcripts including schematic representations:

ENST00000393199 ENST00000393198 ENST00000311032 ENST00000336097 ENST00000013034 ENST00000376392

ENST00000393196 ENST00000393192 ENST00000393194 ENST00000393193 ENST00000393191 ENST00000393190

ENST00000393183 ENST00000393185

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NME2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NME2

¹ / ² / ³

4 probe-sets matching NME2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1980_s_at²^{, 3}	U95-A	3	1.00	0.41	0.92	1.03	X58965	0.80	0.47	0.65	1
33415_at²^{, 3}	U95-A	4	1.00	0.39	0.96	0.97	X58965	0.80	0.47	0.65	1
201268_at²^{, 3}	U133-A	4	1.00	0.40	--	--	NM_002512	0.40	0.44	0.42	1
201268_at²	U133Plus2	4	1.00	0.40	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTGGGTCTA
Expression variation in blood from EXPOLDB for NME2
UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
Tissue specificity: Ubiquitously expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NME2 gene from 5/23 species (see all 23 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NME2¹	--	non-metastatic cells 2, protein (NM23B) expressed in	91.67(n) 92.11(a)	480559 NM_001024638.1 NP_001019809.1
chimpanzee (Pan troglodytes)	NME2¹	--	non-metastatic cells 2, protein (NM23B) expressed in	95.81(n) 92.72(a)	743492 XM_001147407.1 XP_001147407.1
cow (Bos taurus)	NME2¹	--	non-metastatic cells 2, protein (NM23B) expressed in	91.45(n) 93.42(a)	615447 NM_001076376.1 NP_001069844.1
rat (Rattus norvegicus)	Nme2¹	--	non-metastatic cells 2, protein (NM23B) expressed in	91.23(n) 98.03(a)	83782 NM_031833.2 NP_114021.2
mouse (Mus musculus)	Nme2^{1, 5}	11⁵	non-metastatic cells 2, protein (NM23B) expressed in^{1, 5}	90.35(n)¹ 98.03(a)¹	18103¹ NM_008705.4¹ NP_032731.1¹ AK012447⁵ AK150419⁵ (see all 18)

About this table Species with no ortholog for NME2

ENSEMBL Gene Tree for NME2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NME2 gene

NME2P1² NME3² NME7² NME4²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 156491

UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392

This protein is found in reduced amount in tumor cells of high metastatic potential

10/13 Novoseek disease relationships for NME2 gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
burkitt lymphoma	44.63	2	7768941 (2)
tumors	24.18	8	12011429 (1), 7896455 (1), 8601634 (1), 12769686 (1) (see all 7)
cancer	24.09	3	8392752 (1), 17982115 (1), 9619879 (1)
metastasis	15.54	4	8392752 (1), 10632374 (1), 7479028 (1), 9368387 (1)
nasopharyngeal carcinoma	12.69	1	17156515 (1)
breast cancer	10.08	3	17170079 (1), 10713695 (1), 18586674 (1)
cervical carcinoma	9.63	2	8392752 (1)
shock	0.00	2	10946852 (1), 15149734 (1)
melanoma	0.00	1	10400630 (1)
glioma	0.00	1	11857388 (1)

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1 PharmGKB disease relationship for NME2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/156 PubMed articles for NME2 gene (see all 156 ):

Identification of a second human nm23 gene, nm23-H2. (PubMed id 1988104)^{2, 3, 4} Stahl J.A.... King C.R. (1991)
Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. (PubMed id 8392752)^{1, 3, 4} Postel E.H.... Ferrone C.A. (1993)
X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2-A resolution. (PubMed id 8747457)^{1, 3, 4} Morera S.... Janin J. (1995)
Lbc proto-oncogene product binds to and could be negatively regulated by metastasis suppressor nm23-H2. (PubMed id 15249197)^{3, 4} Iwashita S.... Miyamoto M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396. (PubMed id 7488060)^{3, 4} Seifert M.... Welter C. (1995)
The crystal structure of a human nucleoside diphosphate kinase, NM23- H2. (PubMed id 7658474)^{3, 4} Webb P.A.... Williams R.L. (1995)
Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme. (PubMed id 1851158)^{3, 4} Gilles A.-M.... Lascu I. (1991)
Localization of a second NM23 gene, NME2, to chromosome 17q21-q22. (PubMed id 8406509)^{1, 3} Kelsell D.P....Spurr N.K. (1993)
The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma. (PubMed id 7768941)^{1, 3} Ji L....Boxer L.M. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4831	HGNC: 7850	AceView: NME1andNME2	Ensembl:ENSG00000011052	euGenes: HUgn4831
ECgene: NME2	H-InvDB: NME2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NME2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NME2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NME2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NME2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NME2		Antibodies for NME2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NME2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NME2)
	Antibodies (NME2)
	Chimera RNAi (NME2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (NME2)
	Antibodies (NME2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for NME2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NME2

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NME2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for NME2

Summaries
for NME2

Genomic Location
for NME2

Proteins
for NME2

Protein Domains/
Families
for NME2

Gene Function
for NME2

Pathways & Interactions
for NME2

Drugs & Compounds
for NME2

Transcripts
for NME2

Expression
for NME2

Orthologs
for NME2

Paralogs
for NME2

SNPs/Variants
for NME2

Disorders & Mutations
for NME2

Medical News
for NME2

Publications
for NME2

Search for NME2

Genome Databases showing NME2

Other Databases showing NME2

Specialized Databases showing NME2

Licensable Technologies
for NME2

Services
for NME2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NME2 (Gene Symbol)
EC 2.7.4.6
MGC111212
NDPK-B
NDPKB
NM23-H2
NM23B
OTTHUMP00000174727
OTTHUMP00000174728
OTTHUMP00000174774
OTTHUMP00000174775
OTTHUMP00000174776
nm23-H2
puf
C-myc purine-binding transcription factor PUF
NDK B
NDP kinase B
c-myc transcription factor
non-metastatic cells 2, protein (NM23) expressed in
non-metastatic cells 2, protein (NM23B) expressed in
nucleoside diphosphate kinase B

NME2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor NME2

Summariesfor NME2

Genomic Locationfor NME2

Proteinsfor NME2

Protein Domains/Familiesfor NME2

Gene Functionfor NME2

Pathways & Interactionsfor NME2

Drugs & Compoundsfor NME2

Transcriptsfor NME2

Expression for NME2

Orthologsfor NME2

Paralogsfor NME2

SNPs/Variantsfor NME2

Disorders & Mutationsfor NME2

Medical Newsfor NME2

Publicationsfor NME2

Search for NME2

Genome Databases showing NME2

Other Databases showing NME2

Specialized Databases showing NME2

Licensable Technologiesfor NME2

Servicesfor NME2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NME2

Summaries
for NME2

Genomic Location
for NME2

Proteins
for NME2

Protein Domains/
Families
for NME2

Gene Function
for NME2

Pathways & Interactions
for NME2

Drugs & Compounds
for NME2

Transcripts
for NME2

Expression
for NME2

Orthologs
for NME2

Paralogs
for NME2

SNPs/Variants
for NME2

Disorders & Mutations
for NME2

Medical News
for NME2

Publications
for NME2

Licensable Technologies
for NME2

Services
for NME2