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Aliases for NME2 Gene

Aliases for NME2 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 2 2 3 5
  • Non-Metastatic Cells 2, Protein (NM23B) Expressed In 2 3
  • C-Myc Purine-Binding Transcription Factor PUF 3 4
  • Histidine Protein Kinase NDKB 3 4
  • NDP Kinase B 3 4
  • EC 2.7.4.6 4 61
  • NM23-H2 3 4
  • NM23B 3 4
  • Epididymis Secretory Sperm Binding Protein Li 155an 3
  • Non-Metastatic Cells 2, Protein (NM23) Expressed In 3
  • Nucleoside Diphosphate Kinase B 3
  • Nucleotide Diphosphate Kinase B 3
  • C-Myc Transcription Factor 3
  • HEL-S-155an 3
  • EC 2.7.13.3 4
  • NDPK-B 3
  • NDPKB 3
  • NDK B 4
  • NDKB 3
  • PUF 3

External Ids for NME2 Gene

Previous GeneCards Identifiers for NME2 Gene

  • GC17U990063
  • GC17P051725
  • GC17P049584
  • GC17P049718
  • GC17P046598
  • GC17P049242
  • GC17P044612

Summaries for NME2 Gene

Entrez Gene Summary for NME2 Gene

  • Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]

GeneCards Summary for NME2 Gene

NME2 (NME/NM23 Nucleoside Diphosphate Kinase 2) is a Protein Coding gene. Diseases associated with NME2 include Myxosarcoma. Among its related pathways are Validated targets of C-MYC transcriptional activation and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enzyme binding. An important paralog of this gene is NME1-NME2.

UniProtKB/Swiss-Prot for NME2 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

Gene Wiki entry for NME2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME2 Gene

Genomics for NME2 Gene

Regulatory Elements for NME2 Gene

Enhancers for NME2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G050953 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.7 -210.4 -210426 3.0 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF48 GLIS2 ZNF143 ZNF263 NME2 WFIKKN2 NME1 NME1-NME2 ENSG00000251665 ENSG00000247011 ENSG00000249870
GH17G051164 1.1 ENCODE 26.9 +1.2 1247 3.5 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 UTP18 NME2 ENSG00000279089
GH17G050945 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -216.2 -216183 6.8 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 NME1 WFIKKN2 NME1-NME2 NME2 ENSG00000251665 ENSG00000247011 ENSG00000249870
GH17G051029 1.5 Ensembl ENCODE dbSUPER 11.1 -135.4 -135381 2.1 FOXA2 ARNT ZFP64 ARID4B SIN3A SLC30A9 FOS SP5 NFYC MXD4 NME1-NME2 NME1 NME2 ENSG00000251665 ENSG00000249870 ENSG00000247011
GH17G050956 1.4 Ensembl ENCODE dbSUPER 10.7 -208.5 -208462 0.9 ELF3 HDGF PKNOX1 NFIB ARID4B SIN3A KLF17 ZNF2 ZNF48 RAD21 WFIKKN2 NME1 NME1-NME2 NME2 ENSG00000247011 ENSG00000249870
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NME2 on UCSC Golden Path with GeneCards custom track

Promoters for NME2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095800 1465 1801 HDGF MLX CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Transcription factor binding sites by QIAGEN in the NME2 gene promoter:

Genomic Location for NME2 Gene

Chromosome:
17
Start:
51,165,435 bp from pter
End:
51,171,747 bp from pter
Size:
6,313 bases
Orientation:
Plus strand

Genomic View for NME2 Gene

Genes around NME2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME2 Gene

Proteins for NME2 Gene

  • Protein details for NME2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22392-NDKB_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase B
    Protein Accession:
    P22392
    Secondary Accessions:
    • A8MWA3
    • Q1WM23
    • Q6LCT6

    Protein attributes for NME2 Gene

    Size:
    152 amino acids
    Molecular mass:
    17298 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8 (By similarity). Interacts with AKAP13. Interacts ITGB1BP1 (via C-terminal domain region).

    Three dimensional structures from OCA and Proteopedia for NME2 Gene

    Alternative splice isoforms for NME2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NME2 Gene

Selected DME Specific Peptides for NME2 Gene

P22392:
  • MLGETNPADSKPG
  • LWFKPEE
  • MVWEGLNVVKTGR
  • HYIDLKDRPF
  • PVVAMVWEG
  • NIIHGSD
  • SGPVVAMV
  • PGTIRGD
  • RFEQKGF
  • PFFPGLV
  • KPDGVQR

Post-translational modifications for NME2 Gene

  • Ubiquitination at posLast=3939
  • Modification sites at PhosphoSitePlus

Domains & Families for NME2 Gene

Gene Families for NME2 Gene

Protein Domains for NME2 Gene

Suggested Antigen Peptide Sequences for NME2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22392

UniProtKB/Swiss-Prot:

NDKB_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME2: view

Function for NME2 Gene

Molecular function for NME2 Gene

GENATLAS Biochemistry:
non-metastatic cells 2,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of nucleoside diphosphates and acting as a transcription regulator for myc,pyrimidine biosynthetic pathway
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

Enzyme Numbers (IUBMB) for NME2 Gene

Gene Ontology (GO) - Molecular Function for NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 8392752
GO:0004550 nucleoside diphosphate kinase activity IDA,EXP 1851158
GO:0004673 protein histidine kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with NME2: view
genes like me logo Genes that share phenotypes with NME2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NME2

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NME2 Gene

Localization for NME2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NME2 Gene

Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 3 is mainly cytoplasmic and isoform 1 and isoform 3 are excluded from the nucleolus. Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. {ECO:0000269 PubMed:11919189, ECO:0000269 PubMed:16442775}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NME2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 3
plasma membrane 2
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 11919189
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA,IEA 21630459
GO:0005737 cytoplasm IDA,IEA 15703214
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with NME2: view

Pathways & Interactions for NME2 Gene

genes like me logo Genes that share pathways with NME2: view

SIGNOR curated interactions for NME2 Gene

Activates:

Gene Ontology (GO) - Biological Process for NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002762 negative regulation of myeloid leukocyte differentiation IEA --
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
genes like me logo Genes that share ontologies with NME2: view

Drugs & Compounds for NME2 Gene

(20) Drugs for NME2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adefovir Dipivoxil Approved, Investigational Pharma Enzyme, substrate 134
Lamivudine Approved, Investigational Pharma Enzyme, substrate Nucleoside analog reverse transcriptase inhibitor 621
Tenofovir Approved, Investigational Pharma Enzyme, substrate HIV reverse transcriptase inhibitor 759
Adenosine triphosphate Approved Nutra 0
Guanosine diphosphate Experimental Pharma Target 0

(15) Additional Compounds for NME2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxy-Inosine 5'-(tetrahydrogen triphosphate)
  • 2'-Deoxyinosine-5'-triphosphate
  • 2'-Ditp
  • Deoxyinosine 5'-triphosphate
  • Deoxyinosine triphosphate
16595-02-1
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
1173-82-6
genes like me logo Genes that share compounds with NME2: view

Transcripts for NME2 Gene

Unigene Clusters for NME2 Gene

NME/NM23 nucleoside diphosphate kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - -
SP7:

Relevant External Links for NME2 Gene

GeneLoc Exon Structure for
NME2
ECgene alternative splicing isoforms for
NME2

Expression for NME2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NME2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NME2 Gene



Protein tissue co-expression partners for NME2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NME2 Gene:

NME2

SOURCE GeneReport for Unigene cluster for NME2 Gene:

Hs.463456

mRNA Expression by UniProt/SwissProt for NME2 Gene:

P22392-NDKB_HUMAN
Tissue specificity: Isoform 1 and isoform 3 are ubiquitously expressed.

Evidence on tissue expression from TISSUES for NME2 Gene

  • Eye(4)
  • Lymph node(2.3)
genes like me logo Genes that share expression patterns with NME2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NME2 Gene

Orthologs for NME2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NME2 35
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm20390 35
  • 97 (a)
ManyToMany
Nme2 34 16 35
  • 90.35 (n)
Gm4862 35
  • 73 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia NME2 34
  • 91.67 (n)
cow
(Bos Taurus)
Mammalia NME2 34 35
  • 91.45 (n)
rat
(Rattus norvegicus)
Mammalia Nme2 34
  • 91.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NME2 35
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves NME2 35 34
  • 83.89 (n)
ManyToMany
NME1 35
  • 81 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nme2 34
  • 77.7 (n)
Str.5826 34
zebrafish
(Danio rerio)
Actinopterygii nme2b.2 35 34
  • 75.45 (n)
ManyToMany
nme2a 35
  • 68 (a)
ManyToMany
CABZ01038708.1 35
  • 61 (a)
ManyToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta awd 36 35
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea F25H2.5 36
  • 68 (a)
ndk-1 35
  • 68 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 35
  • 60 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5246 34
rice
(Oryza sativa)
Liliopsida Os07g0492000 34
  • 63.74 (n)
Os.146 34
wheat
(Triticum aestivum)
Liliopsida Ta.4748 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 69 (a)
OneToMany
Species where no ortholog for NME2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NME2 Gene

ENSEMBL:
Gene Tree for NME2 (if available)
TreeFam:
Gene Tree for NME2 (if available)

Paralogs for NME2 Gene

Paralogs for NME2 Gene

(8) SIMAP similar genes for NME2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NME2 Gene

genes like me logo Genes that share paralogs with NME2: view

Variants for NME2 Gene

Sequence variations from dbSNP and Humsavar for NME2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000099463 -- 51,164,192(+) TCAGG(A/G)TGGGG intron-variant, upstream-variant-2KB
rs1000321303 -- 51,168,650(+) TGGGC(A/G)ACAGA intron-variant
rs1000422584 -- 51,168,503(+) CAGAC(C/G)TTAGA intron-variant
rs1001811206 -- 51,167,741(+) CAGCA(A/G)TTTGG intron-variant
rs1002267495 -- 51,169,173(+) CGAGG(G/T)GGCTC intron-variant

Variation tolerance for NME2 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NME2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NME2 Gene

Disorders for NME2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NME2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myxosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search NME2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NME2

Genetic Association Database (GAD)
NME2
Human Genome Epidemiology (HuGE) Navigator
NME2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NME2
genes like me logo Genes that share disorders with NME2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NME2 Gene

Publications for NME2 Gene

  1. X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2-A resolution. (PMID: 8747457) Morera S. … Janin J. (Structure 1995) 3 4 22 64
  2. Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. (PMID: 8392752) Postel E.H. … Ferrone C.A. (Science 1993) 3 4 22 64
  3. Identification of a second human nm23 gene, nm23-H2. (PMID: 1988104) Stahl J.A. … King C.R. (Cancer Res. 1991) 2 3 4 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T. … Bobe J. (BMC Evol. Biol. 2009) 2 3 64

Products for NME2 Gene

  • Addgene plasmids for NME2

Sources for NME2 Gene

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