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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NME2 Gene

protein-coding   GIFtS: 70
GCID: GC17P049242

NME/NM23 Nucleoside Diphosphate Kinase 2

(Previous names: non-metastatic cells 2, protein (NM23B) expressed in)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
NME/NM23 Nucleoside Diphosphate Kinase 21 2     NM23-H22
Non-Metastatic Cells 2, Protein (NM23B) Expressed In1 2     PUF2
C-Myc Purine-Binding Transcription Factor PUF2 3     C-Myc Transcription Factor2
Histidine Protein Kinase NDKB2 3     Non-Metastatic Cells 2, Protein (NM23) Expressed In2
NM23B2 3     Nucleoside Diphosphate Kinase B2
NDP Kinase B2 3     Nucleotide Diphosphate Kinase B2
EC 2.7.4.63 8     EC 2.7.13.33
NDKB2     NDK B3
NDPK-B2     nm23-H23
NDPKB2     

External Ids:    HGNC: 78501   Entrez Gene: 48312   Ensembl: ENSG000000110527   OMIM: 1564915   UniProtKB: P223923   
ORGUL members:    fRNAdb10:FR281927      
H-InvDB12:HIT000101220    
NCBI13:D28391    
NONCODE14:n410202      
RNAdb15:HIV2730    

Export aliases for NME2 gene to outside databases

Previous GC identifers: GC17U990063 GC17P051725 GC17P049584 GC17P049718 GC17P046598 GC17P044612


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NME2 Gene:
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this
gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through
transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2)
that encode a fusion protein comprised of sequence sharing identity with each individual gene product. (provided
by RefSeq, Nov 2010)

GeneCards Summary for NME2 Gene: 
NME2 (NME/NM23 nucleoside diphosphate kinase 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with NME2 include chronic interstitial cystitis, and large cell medulloblastoma, and among its related super-pathways are adenosine deoxyribonucleotides de novo biosynthesis I and Purine metabolism. GO annotations related to this gene include protein histidine kinase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NME1.

UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho
activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA
non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity

Gene Wiki entry for NME2 Gene

fRNAdb sequence ontology for NME2:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for NME2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NME2 gene promoter:
         STAT1   AP-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NME2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NME2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

NME2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P049242:  view genomic region     (about GC identifiers)

Start:
49,230,951 bp from pter      End:
49,249,105 bp from pter
Size:
18,155 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for NME2

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392 (See protein sequence)
Recommended Name: Nucleoside diphosphate kinase B  
Size: 152 amino acids; 17298 Da
Cofactor: Magnesium (By similarity)
Subunit: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8 (By
similarity). Interacts with AKAP13. Interacts ITGB1BP1 (via C-terminus domain region)
Subcellular location: Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2
is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus. Colocalizes with ITGB1 and
ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on
fibronectin or collagen but not on vitronectin or laminin substrates
5 PDB 3D structures from and Proteopedia for NME2:
1NSK (3D)        1NUE (3D)        3BBB (3D)        3BBC (3D)        3BBF (3D)    
Secondary accessions: A8MWA3 Q1WM23 Q6LCT6
Alternative splicing: 2 isoforms:  P22392-1   P22392-2   (Based on a naturally occurring readthrough transcript which produces an NME1-NME2 fusion protein. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2)

Explore the universe of human proteins at neXtProt for NME2: NX_P22392

Explore proteomics data for NME2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22392

  • 4/11 DME Specific Peptides for NME2 (P22392) (see all 11)
     LWFKPEE  PGTIRGD  PFFPGLV  RFEQKGF 

    NME2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NME2 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001018147.1  NP_001018148.1  NP_001018149.1  NP_001185611.1  NP_002503.1  

    ENSEMBL proteins: 
     ENSP00000376889   ENSP00000365572   ENSP00000451932   ENSP00000376894   ENSP00000376882  
     ENSP00000376880  
    Reactome Protein details: P22392
    Human Recombinant Protein Products for NME2: 
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    OriGene Purified Protein for NME2
    OriGene Protein Over-expression Lysate for NME2
    OriGene MassSpec for NME2 
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    GenScript Custom Purified and Recombinant Proteins Services for NME2
    Novus Biologicals NME2 Proteins
    Novus Biologicals NME2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for NME2
    Cloud-Clone Corp. Proteins for NME2 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA11919189
    GO:0005634nucleus NAS--
    GO:0005737cytoplasm IDA15703214
    GO:0005739mitochondrion ----
    GO:0005813centrosome ----

    NME2 for ontologies           About GeneDecksing



    NME2 Antibody Products: 
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    Assay Products for NME2: 
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    Cloud-Clone Corp. CLIAs for NME2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR023005 Nucleoside_diP_kinase_AS
     IPR001564 Nucleoside_diP_kinase

    Graphical View of Domain Structure for InterPro Entry P22392

    ProtoNet protein and cluster: P22392

    1 Blocks protein domain: IPB001564 Nucleoside diphosphate kinase

    UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
    Similarity: Belongs to the NDK family


    NME2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDKB_HUMAN, P22392
    Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho
    activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA
    non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity
    Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
    Catalytic activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine

         Genatlas biochemistry entry for NME2:
    non-metastatic cells 2,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the
    phosphorylation of nucleoside diphosphates and acting as a transcription regulator for myc,pyrimidine
    biosynthetic pathway

         Enzyme Numbers (IUBMB): EC 2.7.4.61 2 EC 2.7.13.31

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding ----
    GO:0003677DNA binding IEA--
    GO:0003697single-stranded DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8392752
    GO:0004550nucleoside diphosphate kinase activity IDA1851158
         
    NME2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NME2:
     Increased cell death HMECs cel 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nme2):
     embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging 

    NME2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nme1/Nme2Nme1/tm1Zou for NME2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NME2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NME2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NME2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NME2 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate NME2:
    hsa-miR-3673
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 5): NME2 (NM_001018138)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NME2 About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
    pyrimidine deoxyribonucleotides de novo biosynthesis I0.88
    pyrimidine deoxyribonucleotides de novo biosynthesis II0.73
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)0.88
    CMP phosphorylation0.73
    pyrimidine deoxyribonucleotides biosynthesis from CTP0.88
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.71
    UTP and CTP de novo biosynthesis0.86
    guanosine ribonucleotides de novo biosynthesis0.67
    2Purine metabolism
    Purine metabolism0.38
    ATP/ITP metabolism0.31
    Pyrimidine metabolism0.38
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4adenosine ribonucleotides de novo biosynthesis
    superpathway of purine nucleotides de novo biosynthesis I0.49
    5Purine metabolism
    Metabolism of nucleotides0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NME2
        ATP/ITP metabolism


    1 GeneGo (Thomson Reuters) Pathway for NME2
        ATP/ITP metabolism

    5/17 BioSystems Pathways for NME2 (see all 17)
        superpathway of pyrimidine ribonucleotides de novo biosynthesis
    Nucleotide Metabolism
    superpathway of purine nucleotides de novo biosynthesis I
    Validated targets of C-MYC transcriptional activation
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis

    3        Reactome Pathways for NME2
        Metabolism of nucleotides
    Synthesis and interconversion of nucleotide di- and triphosphates
    Metabolism

    4 PharmGKB Pathways for NME2
        Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
    Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Tenofovir/Adefovir Pathway, Pharmacokinetics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

    3         Kegg Pathways  (Kegg details for NME2):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways


    NME2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NME2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/153 Interacting proteins for NME2 (P223921, 2, 3 ENSP000003655724) via UniProtKB, MINT, STRING, and/or I2D (see all 153)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002762negative regulation of myeloid leukocyte differentiation ----
    GO:0006165nucleoside diphosphate phosphorylation ----
    GO:0006183GTP biosynthetic process IEA--
    GO:0006228UTP biosynthetic process IEA--
    GO:0006241CTP biosynthetic process IEA--

    NME2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NME2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NME2 (NDKB)

    10/21 HMDB Compounds for NME2 (see all 21)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2'-Deoxyinosine triphosphate2'-Deoxyinosine-5'-triphosphate (see all 6)16595-02-1--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CDPCDP (see all 3)63-38-7--
    Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--
    Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--

    4 DrugBank Compounds for NME2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lamivudine-- 134678-17-4enzymesubstrate19887088 15963349
    Adefovir DipivoxilAdefovir (see all 7)142340-99-6enzymesubstrate--
    Guanosine-5'-Diphosphate-- 146-91-8target----
    TenofovirD,L-Tenofovir (see all 4)147127-20-6enzymesubstrate--

    9 Novoseek inferred chemical compound relationships for NME2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 24.3 3 8747457 (2), 18084788 (1)
    phorbol 23.5 1 11668637 (1)
    oligonucleotide 22.6 2 8314536 (1), 7479028 (1)
    guanine 16.5 3 11771757 (1)
    histidine 6.18 2 17157250 (2)
    atp 1.6 3 19544670 (2), 7479028 (1)
    glucose 0 2 19861459 (1), 11727934 (1)
    tyrosine 0 1 19883720 (1)
    tamoxifen 0 1 9751262 (1)

    Search CenterWatch for drugs/clinical trials and news about NME2 / NDKB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for NME2 gene (5 alternative transcripts): 
    NM_001018137.2  NM_001018138.1  NM_001018139.2  NM_001198682.1  NM_002512.3  

    Unigene Cluster for NME2:

    NME/NM23 nucleoside diphosphate kinase 2
    Hs.463456  [show with all ESTs]
    Unigene Representative Sequence: BG114681
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393193(uc002itj.3) ENST00000376392 ENST00000555572(uc002itk.3)
    ENST00000393198 ENST00000393185 ENST00000393183
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NME2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NME2

    Additional mRNA sequence: 

    AF487339.1 AK291105.1 AK309160.1 AL360166.1 AL360191.1 BC000293.2 BC002476.2 BC018994.2 
    BC095458.1 BT007045.1 CR541718.1 CR542104.1 CR542115.1 D28367.1 FJ655905.1 L16785.1 
    M36981.1 NR_037149.1 X17620.1 X58965.1 X73066.1 

    24/53 DOTS entries (see all 53):

    DT.87001740  DT.100666998  DT.92467700  DT.97825132  DT.100667001  DT.95133979  DT.99954390  DT.99926493 
    DT.92467683  DT.100667002  DT.101986310  DT.91951035  DT.91888097  DT.99926485  DT.92041281  DT.87017850 
    DT.100741476  DT.97864707  DT.100847325  DT.92467662  DT.121184671  DT.100667000  DT.100675075  DT.92467701 

    24/233 AceView cDNA sequences (see all 233):

    BG291286 BE786051 BM917154 CB110021 BM769371 CB121817 AA330131 BM765413 
    BI753048 BM765432 BQ676284 AI434165 BM558451 CB115286 BF036960 BC018994 
    AA642220 AI601170 BU943507 CB119291 BU541017 AA373087 BM271914 BF032361 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NME2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                    -     -                       -           -           -                     
    SP2:                    -     -     -                 -           -           -                     
    SP3:                    -     -     -                 -                       -                     
    SP4:                          -                       -           -                                 
    SP5:                    -     -     -                 -           -                                 


    ECgene alternative splicing isoforms for NME2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NME2 expression in normal human tissues (normalized intensities)      NME2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGGGTCTA
    NME2 Expression
    About this image


    NME2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/45 selected tissues (see all 45) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
             brain/midbrain   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See NME2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NME2

    SOURCE GeneReport for Unigene cluster: Hs.463456

    UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
    Tissue specificity: Ubiquitously expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NME2 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nme21 , 5 non-metastatic cells 2, protein (NM23B) expressed in5
    NME/NM23 nucleoside diphosphate kinase 21
    90.35(n)1
    98.03(a)1
      11 (58.88 cM)5
    181031  NM_008705.41  NP_032731.11 
     939498145 
    chicken
    (Gallus gallus)
    Aves NME21 NME/NM23 nucleoside diphosphate kinase 2 83.89(n)
    92.72(a)
      395916  NM_205047.1  NP_990378.1 
    lizard
    (Anolis carolinensis)
    Reptilia NME16
    Nucleoside diphosphate kinase
    87(a)
    possible ortholog
    2(117749525-117771891)
    African clawed frog
    (Xenopus laevis)
    Amphibia X97902.12   -- 78.76(n)    X97902.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055613.12   -- 80.38(n)   30083  BC055613.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta awd3 CTP biosynthesis nucleoside-diphosphate
    kinase
    77(a)   100D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea F25H2.53
    ndk-11
    nucleoside diphosphate kinase3
    Protein NDK-11
    68(a)3
    62.28(n)1
    69.08(a)1
      I(10561041-10562106)3
    1729391  NM_060360.51  NP_492761.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YNK1(YKL067W)4
    YNK11
    Nucleoside diphosphate kinase, catalyzes the transfer more4
    Ynk1p1
    59.91(n)1
    61.49(a)1
      11(314812-315273)4
    8537981, 4  NP_012856.11, 4 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.52462 Vitis vinifera transcribed sequence with moderate similarity more 71.44(n)    CB969468.1 
    rice
    (Oryza sativa)
    Liliopsida Os.1462 Oryza sativa mRNA for nucleoside diphosphate kinase, more 75.83(n)    AK121796.1 


    ENSEMBL Gene Tree for NME2 (if available)
    TreeFam Gene Tree for NME2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NME2 gene
    NME12  NME32  NME82  NME42  NME72  NME1-NME22  NME62  NME92  
    NME52  
    8 SIMAP similar genes for NME2 using alignment to 4 protein entries:     NDKB_HUMAN (see all proteins):
    NME1-NME2    NME1    NME2P1    NME3    c371H6.2    NME4
    NME7    NME6

    NME2 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for NME2
    PGOHUM00000239682 PGOHUM00000258689 PGOHUM00000236638 PGOHUM00000241681


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NME2
    DNA2.0 Custom Variant and Variant Library Synthesis for NME2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 156491OMIM information: 215500 601202 601251 605809 606579 607464 608631 609432 610185    
    20/40 diseases for NME2 (see all 40):    About MalaCards
    chronic interstitial cystitis    large cell medulloblastoma    burkitt's lymphoma    cystitis
    nasopharyngitis    keloids    medulloblastoma    hyperglycemia
    lung adenocarcinoma    down syndrome    oral squamous cell carcinoma    malaria
    cervicitis    chronic myeloid leukemia    retinoblastoma    cystic fibrosis
    astrocytoma    b-cell lymphomas    ovarian cancer    atherosclerosis

    1 disease from the University of Copenhagen DISEASES database for NME2:
    Interstitial cystitis

    NME2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/13 Novoseek inferred disease relationships for NME2 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 42.2 2 7768941 (2)
    cancer 29.8 6 8392752 (1), 19432426 (1), 17982115 (1), 20086171 (1) (see all 6)
    tumors 25.9 10 12011429 (1), 7896455 (1), 19544670 (1), 8601634 (1) (see all 8)
    metastasis 14.9 5 8392752 (1), 10632374 (1), 7479028 (1), 19544670 (1) (see all 5)
    breast cancer 10.3 4 19544670 (1), 17170079 (1), 10713695 (1), 18586674 (1)
    nasopharyngeal carcinoma 9.64 1 17156515 (1)
    cervical carcinoma 6.89 2 8392752 (1)
    breast carcinoma 0 1 7685630 (1)
    shock 0 2 10946852 (1), 15149734 (1)
    glioma 0 1 11857388 (1)

    Genetic Association Database (GAD): NME2
    Human Genome Epidemiology (HuGE) Navigator: NME2 (2 documents)

    Export disorders for NME2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NME2 gene, integrated from 9 sources (see all 205):
    (articles sorted by number of sources associating them with NME2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a second human nm23 gene, nm23-H2. (PubMed id 1988104)1, 2, 3 Stahl J.A.... King C.R. (1991)
    2. Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. (PubMed id 8392752)1, 2, 9 Postel E.H.... Ferrone C.A. (1993)
    3. X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2-A resolution. (PubMed id 8747457)1, 2, 9 Morera S.... Janin J. (1995)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    5. Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)1, 3 Desvignes T....Bobe J. (2009)
    6. Lbc proto-oncogene product binds to and could be negatively regulated by metastasis suppressor nm23-H2. (PubMed id 15249197)1, 2 Iwashita S.... Miyamoto M. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. (PubMed id 11919189)1, 2 Fournier H.N....Albiges-Rizo C. (2002)
    9. Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396. (PubMed id 7488060)1, 2 Seifert M.... Welter C. (1995)
    10. The crystal structure of a human nucleoside diphosphate kinase, NM23- H2. (PubMed id 7658474)1, 2 Webb P.A.... Williams R.L. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4831 HGNC: 7850 AceView: NME1andNME2 Ensembl:ENSG00000011052 euGenes: HUgn4831
    ECgene: NME2 Kegg: 4831 H-InvDB: NME2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NME2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NME2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NME2 gene:
    Search GeneIP for patents involving NME2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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