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NME2 Gene

protein-coding   GIFtS: 70
GCID: GC17P049242

NME/NM23 Nucleoside Diphosphate Kinase 2

(Previous names: non-metastatic cells 2, protein (NM23B) expressed in)
  See NME2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NME/NM23 Nucleoside Diphosphate Kinase 21 2     NM23-H22
Non-Metastatic Cells 2, Protein (NM23B) Expressed In1 2     PUF2
C-Myc Purine-Binding Transcription Factor PUF2 3     C-Myc Transcription Factor2
Histidine Protein Kinase NDKB2 3     Epididymis Secretory Sperm Binding Protein Li 155an2
NM23B2 3     Non-Metastatic Cells 2, Protein (NM23) Expressed In2
NDP Kinase B2 3     Nucleoside Diphosphate Kinase B2
EC 2.7.4.63 8     Nucleotide Diphosphate Kinase B2
HEL-S-155an2     EC 2.7.13.33
NDKB2     NDK B3
NDPK-B2     nm23-H23
NDPKB2     

External Ids:    HGNC: 78501   Entrez Gene: 48312   Ensembl: ENSG000000110527   OMIM: 1564915   UniProtKB: P223923   

Export aliases for NME2 gene to outside databases

Previous GC identifers: GC17U990063 GC17P051725 GC17P049584 GC17P049718 GC17P046598 GC17P044612


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NME2 Gene:
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this
gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through
transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2)
that encode a fusion protein comprised of sequence sharing identity with each individual gene product. (provided
by RefSeq, Nov 2010)

GeneCards Summary for NME2 Gene:
NME2 (NME/NM23 nucleoside diphosphate kinase 2) is a protein-coding gene. Diseases associated with NME2 include acute myeloid leukemia. GO annotations related to this gene include protein histidine kinase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NME1.

UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho
activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA
non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity

Gene Wiki entry for NME2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NME2 gene promoter:
         STAT1   AP-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NME2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

NME2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P049242:  view genomic region     (about GC identifiers)

Start:
49,230,951 bp from pter      End:
49,249,105 bp from pter
Size:
18,155 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for NME2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392 (See protein sequence)
Recommended Name: Nucleoside diphosphate kinase B  
Size: 152 amino acids; 17298 Da
Cofactor: Magnesium (By similarity)
Subunit: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8 (By
similarity). Interacts with AKAP13. Interacts ITGB1BP1 (via C-terminus domain region)
5 PDB 3D structures from and Proteopedia for NME2:
1NSK (3D)        1NUE (3D)        3BBB (3D)        3BBC (3D)        3BBF (3D)    
Secondary accessions: A8MWA3 Q1WM23 Q6LCT6
Alternative splicing: 2 isoforms:  P22392-1   P22392-2   (Based on a naturally occurring readthrough transcript which produces an NME1-NME2 fusion protein. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2)

Explore the universe of human proteins at neXtProt for NME2: NX_P22392

Explore proteomics data for NME2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys39, Lys49, Lys56, Lys85, Lys124, Lys128
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NME2 (P22392) (see all 11)
     LWFKPEE  PGTIRGD  RFEQKGF  PFFPGLV 


    See NME2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001018147.1  NP_001018148.1  NP_001018149.1  NP_001185611.1  NP_002503.1  

    ENSEMBL proteins: 
     ENSP00000376889   ENSP00000365572   ENSP00000451932  
    Reactome Protein details: P22392

    NME2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for NME2
    OriGene Protein Over-expression Lysate for NME2
    OriGene MassSpec for NME2
    OriGene Custom Protein Services for NME2
    GenScript Custom Purified and Recombinant Proteins Services for NME2
    Novus Biologicals NME2 Proteins
    Novus Biologicals NME2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NME2
    Cloud-Clone Corp. Proteins for NME2

     
    Search eBioscience for Proteins for NME2 

    NME2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NME2 (NM23-H2)
    OriGene Antibodies for NME2
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    Novus Biologicals NME2 Antibodies
    Abcam antibodies for NME2
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    ThermoFisher Antibodies for NME2
    LSBio Antibodies in human, mouse, rat for NME2

    NME2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NME2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NME2
    Cloud-Clone Corp. CLIAs for NME2
    Search eBioscience for ELISAs for NME2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR023005 Nucleoside_diP_kinase_AS
     IPR001564 Nucleoside_diP_kinase

    Graphical View of Domain Structure for InterPro Entry P22392

    ProtoNet protein and cluster: P22392

    1 Blocks protein domain: IPB001564 Nucleoside diphosphate kinase

    UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
    Similarity: Belongs to the NDK family


    Find genes that share domains with NME2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDKB_HUMAN, P22392
    Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho
    activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA
    non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity
    Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
    Catalytic activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine

         Genatlas biochemistry entry for NME2:
    non-metastatic cells 2,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the
    phosphorylation of nucleoside diphosphates and acting as a transcription regulator for myc,pyrimidine
    biosynthetic pathway

         Enzyme Numbers (IUBMB): EC 2.7.4.61 2 EC 2.7.13.31

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding ----
    GO:0003677DNA binding IEA--
    GO:0003697single-stranded DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8392752
    GO:0004550nucleoside diphosphate kinase activity IDA1851158
         
    Find genes that share ontologies with NME2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NME2:
     Increased cell death HMECs cel 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nme2):
     embryogenesis  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging 

    Find genes that share phenotypes with NME2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nme1/Nme2Nme1/tm1Zou for NME2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NME2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NME2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NME2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NME2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NME2:
    hsa-mir-197-3p (MIRT048132), hsa-mir-125b-5p (MIRT046082), hsa-mir-221-3p (MIRT046894), hsa-mir-125a-5p (MIRT045749), hsa-mir-1229-3p (MIRT036383), hsa-mir-450b-5p (MIRT037769), hsa-mir-3176 (MIRT052795), hsa-mir-423-5p (MIRT038030), hsa-mir-27a-3p (MIRT050036)

    Block miRNA regulation of human, mouse, rat NME2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NME2:
    hsa-miR-3673
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NME2
    Predesigned siRNA for gene silencing in human, mouse, rat NME2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NME2

    Clone
    Products:
         
    OriGene clones in human, mouse for NME2 (see all 26)
    OriGene ORF clones in mouse, rat for NME2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): NME2 (NM_001018138)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME2
    Addgene plasmids for NME2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NME2
    Browse ESI BIO Cell Lines and PureStem Progenitors for NME2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDKB_HUMAN, P22392: Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2
    is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus. Colocalizes with ITGB1 and
    ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on
    fibronectin or collagen but not on vitronectin or laminin substrates
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    chloroplast2
    cytoskeleton2
    mitochondrion2
    plasma membrane2
    extracellular1
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA11919189
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA15703214
    GO:0005739mitochondrion ----
    GO:0005813centrosome ----

    Find genes that share ontologies with NME2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NME2 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    Pyrimidine metabolism0.38
    purine deoxyribonucleosides salvage0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
    adenosine deoxyribonucleotides de novo biosynthesis0.00
    guanosine deoxyribonucleotides de novo biosynthesis0.52
    pyrimidine deoxyribonucleotides de novo biosynthesis0.00
    superpathway of pyrimidine deoxyribonucleoside salvage0.46
    UTP and CTP de novo biosynthesis0.00
    CMP phosphorylation0.00
    superpathway of pyrimidine ribonucleotides de novo biosynthesis0.00
    4purine nucleotide salvage
    purine nucleotide salvage0.78
    guanosine nucleotides de novo biosynthesis0.00
    purine nucleotides de novo biosynthesis0.78
    guanosine ribonucleotides de novo biosynthesis0.00
    5Purine metabolism (REACTOME)
    Metabolism of nucleotides0.42
    Synthesis and interconversion of nucleotide di- and triphosphates0.00


    Find genes that share SuperPaths with NME2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NME2
        ATP/ITP metabolism

    Selected BioSystems Pathways for NME2 (see all 17)
        purine nucleotides de novo biosynthesis
    superpathway of pyrimidine ribonucleotides de novo biosynthesis
    Nucleotide Metabolism
    purine deoxyribonucleosides salvage
    guanosine nucleotides de novo biosynthesis

    1 Reactome Pathway for NME2
        Synthesis and interconversion of nucleotide di- and triphosphates

    4 PharmGKB Pathways for NME2
        Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
    Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Tenofovir/Adefovir Pathway, Pharmacokinetics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

    3 Kegg Pathways  (Kegg details for NME2):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NME2
    Interactions:

        GeneGlobe Interaction Network for NME2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NME2 (P223921, 2, 3 ENSP000003655724) via UniProtKB, MINT, STRING, and/or I2D (see all 195)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=4 STRING: ENSP00000289352
    HIST1H4FP628053, ENSP000003669744I2D: score=4 STRING: ENSP00000366974
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002762negative regulation of myeloid leukocyte differentiation ----
    GO:0006165nucleoside diphosphate phosphorylation ----
    GO:0006183GTP biosynthetic process IEA--
    GO:0006228UTP biosynthetic process IEA--
    GO:0006241CTP biosynthetic process IEA--

    Find genes that share ontologies with NME2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NME2 (NDKB)

    Selected HMDB Compounds for NME2 (see all 21)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2'-Deoxyinosine triphosphate2'-Deoxyinosine-5'-triphosphate (see all 6)16595-02-1--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CDPCDP (see all 3)63-38-7--
    Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--
    Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--

    4 DrugBank Compounds for NME2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lamivudine-- 134678-17-4enzymesubstrate19887088 15963349
    Adefovir DipivoxilAdefovir (see all 7)142340-99-6enzymesubstrate--
    Guanosine-5'-Diphosphate-- 146-91-8target----
    TenofovirD,L-Tenofovir (see all 4)147127-20-6enzymesubstrate--

    9 Novoseek inferred chemical compound relationships for NME2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 24.3 3 8747457 (2), 18084788 (1)
    phorbol 23.5 1 11668637 (1)
    oligonucleotide 22.6 2 8314536 (1), 7479028 (1)
    guanine 16.5 3 11771757 (1)
    histidine 6.18 2 17157250 (2)
    atp 1.6 3 19544670 (2), 7479028 (1)
    glucose 0 2 19861459 (1), 11727934 (1)
    tyrosine 0 1 19883720 (1)
    tamoxifen 0 1 9751262 (1)



    Find genes that share compounds with NME2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NME2 gene (5 alternative transcripts): 
    NM_001018137.2  NM_001018138.1  NM_001018139.2  NM_001198682.1  NM_002512.3  

    Unigene Cluster for NME2:

    NME/NM23 nucleoside diphosphate kinase 2
    Hs.463456  [show with all ESTs]
    Unigene Representative Sequence: BG114681
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393193(uc002itj.3) ENST00000376392 ENST00000555572(uc002itk.3)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate NME2:
    hsa-miR-3673
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NME2
    Clone
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    OriGene clones in human, mouse for NME2 (see all 26)
    OriGene ORF clones in mouse, rat for NME2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): NME2 (NM_001018138)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME2
    Addgene plasmids for NME2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NME2
    OriGene qSTAR qPCR primer pairs in human, mouse for NME2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat NME2
      QuantiTect SYBR Green Assays in human, mouse, rat NME2
      QuantiFast Probe-based Assays in human, mouse, rat NME2

    Additional mRNA sequence: 

    AF487339.1 AK291105.1 AK309160.1 AL360166.1 AL360191.1 BC000293.2 BC002476.2 BC018994.2 
    BC095458.1 BT007045.1 CR541718.1 CR542104.1 CR542115.1 D28367.1 FJ655905.1 L16785.1 
    M36981.1 NR_037149.1 X17620.1 X58965.1 X73066.1 

    Selected DOTS entries (see all 53):

    DT.87001740  DT.100666998  DT.92467700  DT.97825132  DT.100667001  DT.95133979  DT.99954390  DT.99926493 
    DT.92467683  DT.100667002  DT.101986310  DT.91951035  DT.91888097  DT.92041281  DT.99926485  DT.100741476 
    DT.97864707  DT.87017850  DT.100847325  DT.121184671  DT.92467662  DT.100667000  DT.100675075  DT.92467701 

    Selected AceView cDNA sequences (see all 233):

    BE784067 BP350565 BM850750 BM747087 BM762008 BE779880 BQ682031 BG715349 
    BQ673974 CB110082 CB114844 BQ424005 BM423971 BM855033 AA330131 AU103053 
    BM739634 BM554149 BU935397 BF149316 F36721 AI601170 BM463791 BQ676284 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NME2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                    -     -                       -           -           -                     
    SP2:                    -     -     -                 -           -           -                     
    SP3:                    -     -     -                 -                       -                     
    SP4:                          -                       -           -                                 
    SP5:                    -     -     -                 -           -                                 


    ECgene alternative splicing isoforms for NME2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NME2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGGGTCTA
    NME2 Expression
    About this image


    NME2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Eye (Sensory Organs)
             Mature Rod Bipolar Cells Inner Nuclear Layer
    NME2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NME2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.463456

    UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
    Tissue specificity: Ubiquitously expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NME2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nme21 , 5 non-metastatic cells 2, protein (NM23B) expressed in5
    NME/NM23 nucleoside diphosphate kinase 21
    90.35(n)1
    98.03(a)1
      11 (58.88 cM)5
    181031  NM_008705.51  NP_032731.11 
     939498145 
    chicken
    (Gallus gallus)
    Aves NME21 NME/NM23 nucleoside diphosphate kinase 2 83.89(n)
    92.72(a)
      395916  NM_205047.1  NP_990378.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Nucleoside diphosphate kinase
    49(a)
    1 → many
    2(117749525-117771891)
    African clawed frog
    (Xenopus laevis)
    Amphibia X97902.12   -- 78.76(n)    X97902.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055613.12   -- 80.38(n)   30083  BC055613.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta awd3 CTP biosynthesis nucleoside-diphosphate
    kinase
    77(a)   100D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea F25H2.53 nucleoside diphosphate kinase 68(a)   I(10561041-10562106)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YNK1(YKL067W)4 Nucleoside diphosphate kinase, catalyzes the transfer more   --   11(314812-315273) 853798  NP_012856.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.52462 Vitis vinifera transcribed sequence with moderate similarity more 71.44(n)    CB969468.1 
    rice
    (Oryza sativa)
    Liliopsida Os.1462 Oryza sativa mRNA for nucleoside diphosphate kinase, more 75.83(n)    AK121796.1 


    ENSEMBL Gene Tree for NME2 (if available)
    TreeFam Gene Tree for NME2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NME2 gene
    NME12  NME32  NME82  NME42  NME72  NME1-NME22  NME62  NME92  
    NME52  
    8 SIMAP similar genes for NME2 using alignment to 3 protein entries:     NDKB_HUMAN (see all proteins):
    NME1-NME2    NME1    NME2P1    NME3    c371H6.2    NME4
    NME7    NME6

    Find genes that share paralogs with NME2           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for NME2
    PGOHUM00000239682 PGOHUM00000258689 PGOHUM00000236638 PGOHUM00000241681


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NME2
    DNA2.0 Custom Variant and Variant Library Synthesis for NME2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 156491    OMIM disorders: --

    1 disease for NME2:    
    About MalaCards
    acute myeloid leukemia

    1 disease from the University of Copenhagen DISEASES database for NME2:
    Interstitial cystitis

    Find genes that share disorders with NME2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NME2 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 42.2 2 7768941 (2)
    cancer 29.8 6 8392752 (1), 19432426 (1), 17982115 (1), 20086171 (1) (see all 6)
    tumors 25.9 10 12011429 (1), 7896455 (1), 19544670 (1), 8601634 (1) (see all 8)
    metastasis 14.9 5 8392752 (1), 10632374 (1), 7479028 (1), 19544670 (1) (see all 5)
    breast cancer 10.3 4 19544670 (1), 17170079 (1), 10713695 (1), 18586674 (1)
    nasopharyngeal carcinoma 9.64 1 17156515 (1)
    cervical carcinoma 6.89 2 8392752 (1)
    breast carcinoma 0 1 7685630 (1)
    shock 0 2 10946852 (1), 15149734 (1)
    glioma 0 1 11857388 (1)

    Genetic Association Database (GAD): NME2
    Human Genome Epidemiology (HuGE) Navigator: NME2 (2 documents)

    Export disorders for NME2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NME2 gene, integrated from 10 sources (see all 203):
    (articles sorted by number of sources associating them with NME2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a second human nm23 gene, nm23-H2. (PubMed id 1988104)1, 2, 3 Stahl J.A.... King C.R. (Cancer Res. 1991)
    2. Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. (PubMed id 8392752)1, 2, 9 Postel E.H.... Ferrone C.A. (Science 1993)
    3. X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2-A resolution. (PubMed id 8747457)1, 2, 9 Morera S.... Janin J. (Structure 1995)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)1, 3 Desvignes T....Bobe J. (BMC Evol. Biol. 2009)
    6. Lbc proto-oncogene product binds to and could be negatively regulated by metastasis suppressor nm23-H2. (PubMed id 15249197)1, 2 Iwashita S.... Miyamoto M. (Biochem. Biophys. Res. Commun. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. (PubMed id 11919189)1, 2 Fournier H.N.... Albiges-Rizo C. (J. Biol. Chem. 2002)
    9. Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396. (PubMed id 7488060)1, 2 Seifert M.... Welter C. (Biochem. Biophys. Res. Commun. 1995)
    10. The crystal structure of a human nucleoside diphosphate kinase, NM23- H2. (PubMed id 7658474)1, 2 Webb P.A.... Williams R.L. (J. Mol. Biol. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4831 HGNC: 7850 AceView: NME1andNME2 Ensembl:ENSG00000011052 euGenes: HUgn4831
    ECgene: NME2 Kegg: 4831 H-InvDB: NME2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NME2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NME2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NME2 gene:
    Search GeneIP for patents involving NME2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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