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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NME2 Gene

protein-coding   GIFtS: 70
GCID: GC17P049242

NME/NM23 nucleoside diphosphate kinase 2

(Previous names: non-metastatic cells 2, protein (NM23B) expressed in )
 Explore 42 diseases affiliated with
NME2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NME2    

Aliases
for NME2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
NME/NM23 Nucleoside Diphosphate Kinase 21 2     NDPKB2
NM23-H21 2     PUF2
Non-Metastatic Cells 2, Protein (NM23B) Expressed In1 2     C-Myc Transcription Factor2
C-Myc Purine-Binding Transcription Factor PUF2 3     Non-Metastatic Cells 2, Protein (NM23) Expressed In2
Histidine Protein Kinase NDKB2 3     Nucleoside Diphosphate Kinase B2
NM23B2 3     Nucleotide Diphosphate Kinase B2
NDP Kinase B2 3     EC 2.7.13.33
EC 2.7.4.63 8     NDK B3
NDKB2     Nm23-H21
NDPK-B2     

External Ids:    HGNC: 78501   Entrez Gene: 48312   Ensembl: ENSG000000110527   OMIM: 1564915   UniProtKB: P223923   
ORGUL members:         
NONCODE:n410202    

Export aliases for NME2 gene to outside databases

Previous GC identifers: GC17U990063 GC17P051725 GC17P049584 GC17P049718 GC17P046598 GC17P044612


Summaries
for NME2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NME2:
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this
gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through
transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that
encode a fusion protein comprised of sequence sharing identity with each individual gene product. (provided by RefSeq,
Nov 2010)

UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by
interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically
(PubMed:8392752). Exhibits histidine protein kinase activity

Gene Wiki entry for NME2


Genomic Views
for NME2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NME2 gene promoter:
         STAT1   AP-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NME2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NME2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

NME2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P049242:  view genomic region     (about GC identifiers)

Start:
 49,230,951 bp from pter      End:
 49,249,105 bp from pter
Size:
 18,155 bases      Orientation:
 plus strand

Proteins
for NME2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392 (See protein sequence)
Recommended Name: Nucleoside diphosphate kinase B  
Size: 152 amino acids; 17298 Da
Cofactor: Magnesium (By similarity)
Subunit: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8 (By
similarity). Interacts with AKAP13
Subcellular location: Cytoplasm. Nucleus. Note=Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded
from the nucleolus
5 PDB 3D structures from and Proteopedia for NME2:
1NSK (3D)        1NUE (3D)        3BBB (3D)        3BBC (3D)        3BBF (3D)    
Secondary accessions: A8MWA3 Q1WM23 Q6LCT6
Alternative splicing: 2 isoforms:  P22392-1   P22392-2   (Based on a naturally occurring readthrough transcript which produces an NME1-NME2 fusion protein)

Explore the universe of human proteins at neXtProt for NME2: NX_P22392

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P22392

    • 4/11 DME Specific Peptides for NME2 (P22392) (see all 11)
     LWFKPEE  PGTIRGD  PFFPGLV  RFEQKGF 

    NME2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001018147.1  NP_001018148.1  NP_001018149.1  NP_001185611.1  NP_002503.1  

    ENSEMBL proteins: 
     ENSP00000376889   ENSP00000365572   ENSP00000451932   ENSP00000376894   ENSP00000376882  
     ENSP00000376880  
    Reactome Protein details: P22392
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NME2
    OriGene Protein Over-expression Lysate (see all 6): NME2
    OriGene Custom Protein Services for NME2 
    GenScript Custom Purified and Recombinant Proteins Services for NME2
    Novus Biologicals NME2 Proteins
    Novus Biologicals NME2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for NME2
    Uscn Proteins for NME2

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA11919189
    GO:0005625soluble fraction ----
    GO:0005634nucleus NAS--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----


    NME2 for ontologies           About GeneDecksing



    NME2 Antibody Products: 
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    Assay Products for NME2: 
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NME2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NME2

    Protein Domains /
    Families
    for NME2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NME2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR023005 Nucleoside_diP_kinase_AS
     IPR001564 Nucleoside_diP_kinase

    Graphical View of Domain Structure for InterPro Entry P22392

    ProtoNet protein and cluster: P22392

    1 Blocks protein family: IPB001564 Nucleoside diphosphate kinase

    UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
    Similarity: Belongs to the NDK family


    Function
    for NME2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
    Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by
    interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically
    (PubMed:8392752). Exhibits histidine protein kinase activity
    Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
    Catalytic activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine

         Genatlas biochemistry entry for NME2:
    non-metastatic cells 2,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of
    nucleoside diphosphates and acting as a transcription regulator for myc,pyrimidine biosynthetic pathway

    Enzyme Numbers (IUBMB): EC 2.7.4.61 2 EC 2.7.13.31

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NME2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate NME2:
    hsa-miR-3673
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NME2 (see all 7)
    OriGene shRNA RFP: NME2
    OriGene siRNA: NME2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NME2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NME2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NME2 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NME2 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): NME2 (NM_001018138)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME2 

    Cell Line
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    Search LifeMap BioReagents cell lines for NME2

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NME2

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8392752
    GO:0004550nucleoside diphosphate kinase activity IDA1851158
    GO:0004673protein histidine kinase activity IEA--
    GO:0005515protein binding IPI--


    NME2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NME2:
     Increased cell death HMECs cel 

    Animal Models:
         Mouse knock-out Nme1/Nme2Nme1/tm1Zou for NME2
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nme2):
     embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging 

    NME2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NME2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1pyrimidine ribonucleotides interconversion
    		pyrimidine ribonucleotides interconversion1.00
    		pyrimidine deoxyribonucleotides de novo biosynthesis I0.50
    		pyrimidine ribonucleotides de novo biosynthesis0.88
    		salvage pathways of pyrimidine ribonucleotides0.45
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3ATP/ITP metabolism
    		ATP/ITP metabolism1.00
    		ATP/ITP metabolism0.98
    4Purine metabolism
    		Purine metabolism1.00
    		Pyrimidine metabolism0.38
    5Synthesis and interconversion of nucleotide di- and triphosphates
    		Synthesis and interconversion of nucleotide di- and triphosphates1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NME2
        ATP/ITP metabolism


    1 GeneGo (Thomson Reuters) Pathway for NME2
        ATP/ITP metabolism

    5/6 BioSystems Pathways for NME2 (see all 6) 
        Nucleotide Metabolism
    pyrimidine ribonucleotides de novo biosynthesis
    pyrimidine ribonucleotides interconversion
    Validated targets of C-MYC transcriptional activation
    pyrimidine deoxyribonucleotides de novo biosynthesis I

    3        Reactome Pathways for NME2
        Metabolism of nucleotides
    Synthesis and interconversion of nucleotide di- and triphosphates
    Metabolism

    3 PharmGKB Pathways for NME2
        Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Tenofovir/Adefovir Pathway, Pharmacokinetics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

    3         Kegg Pathways  (Kegg details for NME2):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways


    NME2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NME2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/149 Interacting proteins for NME2 (P223921, 2, 3 ENSP000003655724) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002762negative regulation of myeloid leukocyte differentiation ----
    GO:0006165nucleoside diphosphate phosphorylation ----
    GO:0006183GTP biosynthetic process IEA--
    GO:0006228UTP biosynthetic process IEA--
    GO:0006241CTP biosynthetic process IEA--


    NME2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NME2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NME2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NME2

    10/21 HMDB Compounds for NME2 (see all 21)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2'-Deoxyinosine triphosphate2'-Deoxyinosine-5'-triphosphate (see all 6)16595-02-1--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CDPCDP (see all 3)63-38-7--
    Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--
    Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--

    1 DrugBank Compound for NME2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target----

    9 Novoseek chemical compound relationships for NME2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 24.3 3 8747457 (2), 18084788 (1)
    phorbol 23.5 1 11668637 (1)
    oligonucleotide 22.6 2 8314536 (1), 7479028 (1)
    guanine 16.5 3 11771757 (1)
    histidine 6.18 2 17157250 (2)
    atp 1.6 3 19544670 (2), 7479028 (1)
    glucose 0 2 19861459 (1), 11727934 (1)
    tyrosine 0 1 19883720 (1)
    tamoxifen 0 1 9751262 (1)

    Search CenterWatch for drugs/clinical trials and news about NME2 / NDKB 

    Transcripts
    for NME2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NME2 gene (5 alternative transcripts): 
    NM_001018137.2  NM_001018138.1  NM_001018139.2  NM_001198682.1  NM_002512.3  

    Unigene Cluster for NME2:

    NME/NM23 nucleoside diphosphate kinase 2
    Hs.463456  [show with all ESTs]
    Unigene Representative Sequence: BG114681
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393193(uc002itj.3) ENST00000376392 ENST00000555572(uc002itk.3)
    ENST00000393198 ENST00000393185 ENST00000393183

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): NME2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NME2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate NME2:
    hsa-miR-3673
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NME2 (see all 7)
    OriGene shRNA RFP: NME2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NME2
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 5): NME2 (NM_001018138)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NME2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NME2

    Additional cDNA sequence: 

    AF487339.1 AK291105.1 AK309160.1 AL360166.1 AL360191.1 BC000293.2 BC002476.2 BC018994.2 
    BC095458.1 BT007045.1 CR541718.1 CR542104.1 CR542115.1 D28367.1 FJ655905.1 L16785.1 
    M36981.1 NR_037149.1 X17620.1 X58965.1 X73066.1 

    24/53 DOTS entries (see all 53):

    DT.87001740  DT.100666998  DT.92467700  DT.97825132  DT.100667001  DT.95133979  DT.99954390  DT.99926493 
    DT.92467683  DT.100667002  DT.101986310  DT.91951035  DT.91888097  DT.99926485  DT.92041281  DT.87017850 
    DT.100741476  DT.97864707  DT.100847325  DT.92467662  DT.121184671  DT.100667000  DT.100675075  DT.92467701 

    24/233 AceView cDNA sequences (see all 233):

    BU186842 BM772953 F36721 BX421668 CR610816 AI601170 BM766769 BQ672712 
    AA319381 BU182293 CB107783 BM553122 BG715349 BG531125 BQ435141 CB110082 
    BU935397 BQ954869 BQ883643 AW768951 BM562979 BI753048 BM799683 BC000293 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NME2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                    -     -                       -           -           -                     
    SP2:                    -     -     -                 -           -           -                     
    SP3:                    -     -     -                 -                       -                     
    SP4:                          -                       -           -                                 
    SP5:                    -     -     -                 -           -                                 


    ECgene alternative splicing isoforms for NME2

    Expression
    for NME2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NME2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTGGGTCTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NME2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See NME2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NME2

    SOURCE GeneReport for Unigene cluster: Hs.463456

    UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
    Tissue specificity: Ubiquitously expressed

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    Orthologs
    for NME2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for NME2 gene from 10/39 species (see all 39)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NME21 NME/NM23 nucleoside diphosphate kinase 2 83.89(n)
    92.72(a)    		   395916  NM_205047.1  NP_990378.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 5)    		 --
    		 88(a)
    29(a)
    (see all 5)    		 1 ↔ many
    possible ortholog
    (see all 5)    		 2(117754712-117771891)
    6(47767459-47772252)
    African clawed frog
    (Xenopus laevis)    		 Amphibia X97902.12   -- 78.76(n)    X97902.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC055613.12   -- 80.38(n)   30083  BC055613.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta awd3 CTP biosynthesis nucleoside-diphosphate
    kinase    		 77(a)   100D2   --
    worm
    (Caenorhabditis elegans)    		 Secernentea F25H2.53
    ndk-11    		 nucleoside diphosphate kinase3
    Protein NDK-11    		 68(a)3
    62.28(n)1
    69.08(a)1    		   I(10561041-10562106)3
    1729391  NM_060360.51  NP_492761.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes YNK1(YKL067W)4
    YNK11    		 Nucleoside diphosphate kinase, catalyzes the transfer more4
    Ynk1p1    		 59.91(n)1
    61.49(a)1    		   11(314812-315273)4
    8537981, 4  NP_012856.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NDPK16
    AT4G239006
    (see all 6)    		 nucleoside diphosphate kinase IV
    (see all 6)    		 55(a)
    40(a)
    (see all 6)    		 possible ortholog
    many ↔ many
    (see all 6)    		 4(5923400-5924532)
    4(12424451-12426528)
    rice
    (Oryza sativa)    		 Liliopsida Os.1462 Oryza sativa mRNA for nucleoside diphosphate kinase, more 75.83(n)    AK121796.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria ndk6
    		 multifunctional nucleoside diphosphate kinase and ...
    		 41(a)
    		 possible ortholog
    		 Chromosome(2642455-2642886)


    ENSEMBL Gene Tree for NME2 (if available)
    TreeFam Gene Tree for NME2 (if available) 

    Paralogs
    for NME2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NME2 gene
    NME12  NME32  NME82  NME42  NME72  NME1-NME22  NME62  NME92  
    NME52  
    8 SIMAP similar genes for NME2 using alignment to 4 protein entries:     NDKB_HUMAN (see all proteins):
    NME1-NME2    NME1    NME2P1    NME3    c371H6.2    NME4
    NME7    NME6

    NME2 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for NME2
    PGOHUM00000239682 PGOHUM00000258689 PGOHUM00000236638 PGOHUM00000241681


    Genomic Variants
    for NME2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/137 NCBI SNPs in NME2 are shown (see all 137)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1485906641,2
    		--49240796(+) TTCCTC/GTCACA 3 -- us2k1 int10--------
    rs129415931,2
    		F,H--49241007(+) ggcacG/Atgcca 3 -- int1 us2k16Minor allele frequency- A:0.00NS EA NA 420
    rs1125176581,2
    		C,--49241098(+) CAAGCG/AATCTG 3 -- int1 us2k11Minor allele frequency- A:0.50WA 2
    rs1878047611,2
    		--49241278(+) GGTTCA/GAGCGA 3 -- us2k1 int10--------
    rs1477728981,2
    		--49241473(+) TGCGAA/CTGGCC 3 -- int1 us2k10--------
    rs1395194941,2
    		--49241474(+) GCGACA/TGGCCA 3 -- int1 us2k10--------
    rs1451218271,2
    		--49241519(+) GCTTCA/GGTAGA 3 -- us2k1 int10--------
    rs599921661,2
    		C--49241632(+) TTTTT-/TTTGAGAC 3 -- int1 us2k11Minor allele frequency- TTT:0.00NA 2
    rs1911112231,2
    		--49241683(+) CCAGGC/TGGGAA 5 -- int1 us2k10--------
    rs1836213511,2
    		--49241790(+) CGCCAC/TCATGC 5 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for NME2 (49230951 - 49249105 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NME2: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for NME2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NME2 for disorders           About GeneDecksing

    OMIM gene information: 156491    OMIM disorders: --

    20/42 diseases for NME2 (see all 42):    About MalaCards
    burkitt's lymphoma    large cell medulloblastoma    b-cell lymphomas    oral squamous cell carcinoma
    squamous cell carcinoma    epithelial ovarian cancer    cystic fibrosis    cervical carcinoma
    medulloblastoma    carcinoma    down syndrome    keloids
    ovarian cancer    nasopharyngitis    breast carcinoma    cervicitis
    breast cancer    endometrial cancer    lung adenocarcinoma    hyperglycemia

    2 diseases from the University of Copenhagen DISEASES database for NME2:
    Interstitial cystitis     Chronic interstitial cystitis

    10/13 Novoseek disease relationships for NME2 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 42.2 2 7768941 (2)
    cancer 29.8 6 8392752 (1), 19432426 (1), 17982115 (1), 20086171 (1) (see all 6)
    tumors 25.9 10 12011429 (1), 7896455 (1), 19544670 (1), 8601634 (1) (see all 8)
    metastasis 14.9 5 8392752 (1), 10632374 (1), 7479028 (1), 19544670 (1) (see all 5)
    breast cancer 10.3 4 19544670 (1), 17170079 (1), 10713695 (1), 18586674 (1)
    nasopharyngeal carcinoma 9.64 1 17156515 (1)
    cervical carcinoma 6.89 2 8392752 (1)
    breast carcinoma 0 1 7685630 (1)
    shock 0 2 10946852 (1), 15149734 (1)
    glioma 0 1 11857388 (1)

    Human Genome Epidemiology (HuGE) Navigator: NME2 (2 documents)

    Export disorders for NME2 gene to outside databases

    Publications
    for NME2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NME2 gene, integrated from 9 sources (see all 187):
    (articles sorted by number of sources associating them with NME2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a second human nm23 gene, nm23-H2. (PubMed id 1988104)1, 2, 3 Stahl J.A.... King C.R. (1991)
    2. Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. (PubMed id 8392752)1, 2, 9 Postel E.H.... Ferrone C.A. (1993)
    3. X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2-A resolution. (PubMed id 8747457)1, 2, 9 Morera S.... Janin J. (1995)
    4. Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)1, 3 Desvignes T....Bobe J. (2009)
    5. Lbc proto-oncogene product binds to and could be negatively regulated by metastasis suppressor nm23-H2. (PubMed id 15249197)1, 2 Iwashita S.... Miyamoto M. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396. (PubMed id 7488060)1, 2 Seifert M.... Welter C. (1995)
    8. The crystal structure of a human nucleoside diphosphate kinase, NM23- H2. (PubMed id 7658474)1, 2 Webb P.A.... Williams R.L. (1995)
    9. Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme. (PubMed id 1851158)1, 2 Gilles A.-M.... Lascu I. (1991)
    10. Localization of a second NM23 gene, NME2, to chromosome 17q21-q22. (PubMed id 8406509)1, 9 Kelsell D.P....Spurr N.K. (1993)

    External Searches for NME2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NME2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4831 HGNC: 7850 AceView: NME1andNME2 Ensembl:ENSG00000011052 euGenes: HUgn4831
    ECgene: NME2 Kegg: 4831 H-InvDB: NME2

    Other Databases showing NME2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NME2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NME2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NME2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NME2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NME2 gene:
    Search GeneIP for patents involving NME2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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