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NME1-NME2 Gene

protein-coding   GIFtS: 47
GCID: GC17P049230

NME1-NME2 Readthrough

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NME1-NME2 Readthrough1 2     NM23B3
EC 2.7.4.63 8     C-Myc Purine-Binding Transcription Factor PUF3
NM23-LV2     Histidine Protein Kinase NDKB3
NMELV2     NDK B3
NME1-NME2 Protein2     NDP Kinase B3
NME1-NME2 Readthrough Transcript2     nm23-H23
EC 2.7.13.33     

External Ids:    HGNC: 335311   Entrez Gene: 6543642   Ensembl: ENSG000002436787   UniProtKB: P223923   

Export aliases for NME1-NME2 gene to outside databases

Previous GC identifers: GC17U900586 GC17P046586 GC17P044600


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NME1-NME2 Gene:
This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes.
The significance of this read-through transcription and the function of the resulting protein product have not
yet been determined. Alternative splicing of this gene results in multiple transcript variants. (provided by
RefSeq, Nov 2010)

GeneCards Summary for NME1-NME2 Gene:
NME1-NME2 (NME1-NME2 readthrough) is a protein-coding gene. Diseases associated with NME1-NME2 include chronic interstitial cystitis, and cystitis. An important paralog of this gene is NME2.

UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho
activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA
non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity

Gene Wiki entry for NME1-NME2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for NME1-NME2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NME1-NME2 promoter sequence
   Search Chromatin IP Primers for NME1-NME2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME1-NME2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

NME1-NME2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME1-NME2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P049230:  view genomic region     (about GC identifiers)

Start:
49,230,897 bp from pter      End:
49,249,108 bp from pter
Size:
18,212 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for NME1-NME2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392 (See protein sequence)
Recommended Name: Nucleoside diphosphate kinase B  
Size: 152 amino acids; 17298 Da
Cofactor: Magnesium (By similarity)
Subunit: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8 (By
similarity). Interacts with AKAP13. Interacts ITGB1BP1 (via C-terminus domain region)
5 PDB 3D structures from and Proteopedia for NME1-NME2:
1NSK (3D)        1NUE (3D)        3BBB (3D)        3BBC (3D)        3BBF (3D)    
Secondary accessions: A8MWA3 Q1WM23 Q6LCT6
Alternative splicing: 2 isoforms:  P22392-1   P22392-2   (Based on a naturally occurring readthrough transcript which produces an NME1-NME2 fusion protein. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2)

Explore the universe of human proteins at neXtProt for NME1-NME2: NX_P22392

Explore proteomics data for NME1-NME2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus (NME1-NME2)
  • Selected DME Specific Peptides for NME1-NME2 (P22392) (see all 11)
     LWFKPEE  PGTIRGD  RFEQKGF  PFFPGLV 


    See NME1-NME2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001018146.1  
    ENSEMBL proteins: 
     ENSP00000426976   ENSP00000425581   ENSP00000421064   ENSP00000426901   ENSP00000376886  
     ENSP00000477284   ENSP00000376894   ENSP00000376882   ENSP00000376880  
    Reactome Protein details: P22392

    NME1-NME2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR023005 Nucleoside_diP_kinase_AS
     IPR001564 Nucleoside_diP_kinase

    Graphical View of Domain Structure for InterPro Entry P22392

    ProtoNet protein and cluster: P22392

    1 Blocks protein domain: IPB001564 Nucleoside diphosphate kinase

    UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
    Similarity: Belongs to the NDK family


    NME1-NME2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDKB_HUMAN, P22392
    Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho
    activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA
    non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity
    Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
    Catalytic activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine

         Enzyme Numbers (IUBMB): EC 2.7.4.61 2 EC 2.7.13.31

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding ----
    GO:0003677DNA binding ----
    GO:0003697single-stranded DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0004550nucleoside diphosphate kinase activity ----
         
    NME1-NME2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NME1-NME2:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NME1-NME2
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    1 qRT-PCR Assays for microRNA that regulate NME1-NME2:
    hsa-miR-3673
    SwitchGear 3'UTR luciferase reporter plasmidNME1-NME2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDKB_HUMAN, P22392: Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2
    is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus. Colocalizes with ITGB1 and
    ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on
    fibronectin or collagen but not on vitronectin or laminin substrates
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    plasma membrane2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----
    GO:0005813centrosome ----

    NME1-NME2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NME1-NME2 About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    purine deoxyribonucleosides salvage0.00
    Pyrimidine metabolism0.38
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
    adenosine deoxyribonucleotides de novo biosynthesis0.00
    guanosine deoxyribonucleotides de novo biosynthesis0.52
    pyrimidine deoxyribonucleotides de novo biosynthesis0.00
    superpathway of pyrimidine deoxyribonucleoside salvage0.46
    UTP and CTP de novo biosynthesis0.00
    CMP phosphorylation0.00
    superpathway of pyrimidine ribonucleotides de novo biosynthesis0.00
    4purine nucleotide salvage
    purine nucleotide salvage0.78
    guanosine nucleotides de novo biosynthesis0.00
    purine nucleotides de novo biosynthesis0.78
    guanosine ribonucleotides de novo biosynthesis0.00
    5Purine metabolism (REACTOME)
    Metabolism of nucleotides0.42
    Synthesis and interconversion of nucleotide di- and triphosphates0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NME1-NME2
        ATP/ITP metabolism

    Selected BioSystems Pathways for NME1-NME2 (see all 17)
        purine nucleotides de novo biosynthesis
    superpathway of pyrimidine ribonucleotides de novo biosynthesis
    Nucleotide Metabolism
    purine deoxyribonucleosides salvage
    guanosine nucleotides de novo biosynthesis

    1 Reactome Pathway for NME1-NME2
        Synthesis and interconversion of nucleotide di- and triphosphates


    3 Kegg Pathways  (Kegg details for NME1-NME2):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways


    NME1-NME2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NME1-NME2
    Interactions:

        Search GeneGlobe Interaction Network for NME1-NME2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NME1-NME2 (P223921, 2, 3 ENSP000003768864) via UniProtKB, MINT, STRING, and/or I2D (see all 268)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4FP628053, ENSP000003669744I2D: score=4 STRING: ENSP00000366974
    HIST1H4HP628053, ENSP000002893524I2D: score=4 STRING: ENSP00000289352
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002762negative regulation of myeloid leukocyte differentiation ----
    GO:0006165nucleoside diphosphate phosphorylation ----
    GO:0006183GTP biosynthetic process ----
    GO:0006228UTP biosynthetic process ----
    GO:0006241CTP biosynthetic process ----

    NME1-NME2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NME1-NME2 (NDKB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NME1-NME2 gene: 
    NM_001018136.2  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514264(uc002itl.3) ENST00000513177 ENST00000512737(uc002itm.3 uc021uae.1)
    ENST00000503064(uc002itn.3) ENST00000485076 ENST00000393190(uc002ito.3)
    ENST00000570801 ENST00000573262 ENST00000608447 ENST00000393198 ENST00000393185
    ENST00000393183
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    1 qRT-PCR Assays for microRNA that regulate NME1-NME2:
    hsa-miR-3673
    SwitchGear 3'UTR luciferase reporter plasmidNME1-NME2 3' UTR sequence
    Inhib. RNA
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      Search QuantiTect SYBR Green Assays in human, mouse, rat NME1-NME2
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NME1-NME2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NME1-NME2 Expression
    About this image

    NME1-NME2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NME1-NME2 Protein Expression

    UniProtKB/Swiss-Prot: NDKB_HUMAN, P22392
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NME1-NME2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm55661 , 5 predicted pseudogene 55661, 5 89.47(n)1
    94.74(a)1
      5 (89.18 cM)5
    4339681  XM_006504950.11  XP_006505013.11 
     1496607655 
    chicken
    (Gallus gallus)
    Aves NME26
    NME16
    Gallus gallus NME/NM23 nucleoside diphosphate kina...
    Gallus gallus non-metastatic cells 1, protein (NM2...
    92(a)
    81(a)
    many ↔ many
    many ↔ many
    18(5038160-5040118)
    18(10253363-10256902)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Nucleoside diphosphate kinase
    49(a)
    1 → many
    2(117749525-117771891)
    zebrafish
    (Danio rerio)
    Actinopterygii nme2a1 NME/NM23 nucleoside diphosphate kinase 2a 71.36(n)
    79.19(a)
      335716  NM_199970.1  NP_956264.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta awd1 abnormal wing discs 69.28(n)
    72.89(a)
      43739  NM_057413.4  NP_476761.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ndk-11 ndk-1 62.28(n)
    69.08(a)
      172939  NM_060360.6  NP_492761.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YNK11 YNK1 58.94(n)
    60.26(a)
      853798   NP_012856.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NDPK11 NDPK1 61.01(n)
    59.12(a)
      826515  NM_117000.2  NP_567346.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g05637001 Os10g0563700 63.29(n)
    61.49(a)
      4349403  NM_001071936.1  NP_001065404.1 


    ENSEMBL Gene Tree for NME1-NME2 (if available)
    TreeFam Gene Tree for NME1-NME2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NME1-NME2 gene
    NME22  NME12  NME32  NME82  NME42  NME72  NME62  NME92  
    NME52  
    6 SIMAP similar genes for NME1-NME2 using alignment to 2 protein entries:     F6XY72_HUMAN (see all proteins):
    NME2    NME1    NME2P1    NME3    c371H6.2    NME4

    NME1-NME2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NME1-NME2
    PGOHUM00000240634 PGOHUM00000236733


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NME1-NME2 (see all 11)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs800750321,2
    C,F--49239999(+) CCCAGG/CAGTCC 2 -- int15Minor allele frequency- C:0.15NA WA EA 362
    rs355179131,2
    C,F--49240037(+) ACTGTA/CCTTCA 2 -- int111Minor allele frequency- C:0.49NA WA CSA EA 372
    rs1461032921,2
    --49240080(+) AAAAAC/TATATC 2 -- int10--------
    rs47942091,2
    C,F--49240131(+) GGGAGT/CGTGGG 2 -- int18Minor allele frequency- C:0.21NA CSA WA EA 367
    rs1831044711,2
    --49240400(+) TGAGAA/CCAGCC 2 -- int10--------
    rs1401270301,2
    C--49240503(+) GAGGTA/GGGAGG 2 -- int10--------
    rs786043571,2
    F--49240532(+) GTTGGA/TGCAGT 2 -- int11Minor allele frequency- T:0.03EA 120
    rs1494109391,2
    --49240662(+) GGTGGA/TCTACA 2 -- int10--------
    rs1448301681,2
    --49240670(+) ACACAC/TACCTG 2 -- int10--------
    rs3716444181,2
    ----49239959(+) TAGTCC/TAGCTA 2 -- int10--------

    HapMap Linkage Disequilibrium report for NME1-NME2 (49230897 - 49249108 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NME1-NME2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NME1-NME2
    DNA2.0 Custom Variant and Variant Library Synthesis for NME1-NME2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for NME1-NME2:    About MalaCards
    chronic interstitial cystitis    cystitis    pneumonia    tuberculosis
    malaria

    1 disease from the University of Copenhagen DISEASES database for NME1-NME2:
    Interstitial cystitis

    NME1-NME2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NME1-NME2
    Human Genome Epidemiology (HuGE) Navigator: NME1-NME2 (1 document)

    Export disorders for NME1-NME2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NME1-NME2 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with NME1-NME2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV. (PubMed id 16442775)1, 2, 3 Valentijn L.J.... Versteeg R. (Genomics 2006)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. (PubMed id 11919189)1, 2 Fournier H.N.... Albiges-Rizo C. (J. Biol. Chem. 2002)
    4. Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. (PubMed id 8392752)1, 2 Postel E.H.... Ferrone C.A. (Science 1993)
    5. Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme. (PubMed id 1851158)1, 2 Gilles A.-M.... Lascu I. (J. Biol. Chem. 1991)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 654364 HGNC: 33531 Ensembl:ENSG00000243678 euGenes: HUgn654364 ECgene: NME1-NME2 Kegg: 654364
    H-InvDB: NME1-NME2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NME1-NME2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NME1-NME2 gene:
    Search GeneIP for patents involving NME1-NME2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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