Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NME1-NME2 Gene

Aliases for NME1-NME2 Gene

  • NME1-NME2 Readthrough 2 3 5
  • NME1-NME2 Readthrough Transcript 3
  • NME1-NME2 Protein 3
  • NM23-LV 3
  • NMELV 3

External Ids for NME1-NME2 Gene

Previous GeneCards Identifiers for NME1-NME2 Gene

  • GC17U900586
  • GC17P046586
  • GC17P049230
  • GC17P044600

Summaries for NME1-NME2 Gene

Entrez Gene Summary for NME1-NME2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for NME1-NME2 Gene

NME1-NME2 (NME1-NME2 Readthrough) is a Protein Coding gene. Diseases associated with NME1-NME2 include Bladder Disease and Pain Disorder. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Pyrimidine metabolism (KEGG). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein histidine kinase activity. An important paralog of this gene is NME1.

Gene Wiki entry for NME1-NME2 Gene

Additional gene information for NME1-NME2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME1-NME2 Gene

Genomics for NME1-NME2 Gene

Regulatory Elements for NME1-NME2 Gene

Enhancers for NME1-NME2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H050945 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -204.3 -204284 6.8 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 CBX5 NME2 NME1 MBTD1 WFIKKN2 NME1-NME2 COL1A1 ENSG00000251665 ENSG00000247011 ENSG00000249870
GH17H050953 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -198.5 -198527 3 ARID4B FEZF1 ZNF2 GLIS2 SP3 REST TSHZ1 ZNF518A NFIL3 ZNF610 NME2 WFIKKN2 NME1 NME1-NME2 ENSG00000251665 ENSG00000247011 ENSG00000249870
GH17H050956 1.4 Ensembl ENCODE dbSUPER 10.7 -196.6 -196563 0.9 ELF3 HDGF PKNOX1 NFIB ARID4B SIN3A KLF17 ZNF2 RAD21 ZNF207 WFIKKN2 NME1 NME1-NME2 NME2 ENSG00000247011 ENSG00000249870
GH17H051056 1.2 Ensembl ENCODE dbSUPER 11.5 -96.2 -96224 1.9 CTCF TFAP4 ZNF654 PKNOX1 NFRKB TRIM22 ZIC2 RAD21 TEAD3 MIER3 NME1 NME1-NME2 NME2 ENSG00000251665 WFIKKN2 ENSG00000249870 SPAG9
GH17H051029 1.2 Ensembl ENCODE dbSUPER 11.1 -123.5 -123482 2.1 ZNF146 IRF2 ZNF687 NR2F1 JUNB CEBPG IKZF1 ATF7 RUNX3 IKZF2 NME1 NME1-NME2 NME2 ENSG00000251665 ENSG00000249870 ENSG00000247011
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NME1-NME2 on UCSC Golden Path with GeneCards custom track

Promoters for NME1-NME2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095799 264 2001 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC

Genomic Locations for NME1-NME2 Gene

Genomic Locations for NME1-NME2 Gene
18,209 bases
Plus strand

Genomic View for NME1-NME2 Gene

Genes around NME1-NME2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME1-NME2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME1-NME2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME1-NME2 Gene

Proteins for NME1-NME2 Gene

  • Protein details for NME1-NME2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    NME1-NME2 readthrough
    Protein Accession:

    Protein attributes for NME1-NME2 Gene

    197 amino acids
    Molecular mass:
    22422 Da
    Quaternary structure:
    No Data Available
  • Protein details for NME1-NME2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Nucleoside diphosphate kinase
    Protein Accession:

    Protein attributes for NME1-NME2 Gene

    292 amino acids
    Molecular mass:
    32642 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NME1-NME2 Gene

Post-translational modifications for NME1-NME2 Gene

No Post-translational modifications

Other Protein References for NME1-NME2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NME1-NME2 Gene

Domains & Families for NME1-NME2 Gene

Gene Families for NME1-NME2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for NME1-NME2 Gene

Suggested Antigen Peptide Sequences for NME1-NME2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NME1-NME2: view

No data available for UniProtKB/Swiss-Prot for NME1-NME2 Gene

Function for NME1-NME2 Gene

Gene Ontology (GO) - Molecular Function for NME1-NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NME1-NME2: view
genes like me logo Genes that share phenotypes with NME1-NME2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NME1-NME2 Gene

Localization for NME1-NME2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NME1-NME2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NME1-NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NME1-NME2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NME1-NME2 Gene

Pathways & Interactions for NME1-NME2 Gene

genes like me logo Genes that share pathways with NME1-NME2: view

Interacting Proteins for NME1-NME2 Gene

Gene Ontology (GO) - Biological Process for NME1-NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with NME1-NME2: view

No data available for SIGNOR curated interactions for NME1-NME2 Gene

Drugs & Compounds for NME1-NME2 Gene

No Compound Related Data Available

Transcripts for NME1-NME2 Gene

mRNA/cDNA for NME1-NME2 Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME1-NME2 Gene

No ASD Table

Relevant External Links for NME1-NME2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NME1-NME2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NME1-NME2 Gene

Protein differential expression in normal tissues from HIPED for NME1-NME2 Gene

This gene is overexpressed in Saliva (16.3) and Brain (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb, MaxQB, and MOPED for NME1-NME2 Gene

Protein tissue co-expression partners for NME1-NME2 Gene

Evidence on tissue expression from TISSUES for NME1-NME2 Gene

  • Eye(4.3)
  • Liver(2.4)
  • Blood(2.2)
  • Nervous system(2.2)
  • Lung(2.1)
  • Lymph node(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with NME1-NME2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NME1-NME2 Gene

Orthologs for NME1-NME2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME1-NME2 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia NME2 34
  • 97 (a)
(Mus musculus)
Mammalia Gm20390 34
  • 97 (a)
Nme2 34
  • 97 (a)
Gm5566 33 16
  • 89.47 (n)
(Pan troglodytes)
Mammalia LOC101059613 33
  • 96.35 (n)
-- 34
  • 92 (a)
-- 34
  • 76 (a)
(Bos Taurus)
Mammalia NME2 34
  • 96 (a)
LOC101905864 33
  • 74.34 (n)
(Ornithorhynchus anatinus)
Mammalia NME2 34
  • 86 (a)
(Gallus gallus)
Aves NME2 34
  • 92 (a)
NME1 34
  • 81 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
(Danio rerio)
Actinopterygii nme2b.2 34
  • 78 (a)
nme2a 33 34
  • 71.36 (n)
CABZ01038708.1 34
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta awd 33 34
  • 69.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007120 33
  • 67.5 (n)
(Caenorhabditis elegans)
Secernentea ndk-1 33 34
  • 62.28 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03696g 33
  • 60.96 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR096C 33
  • 59.91 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 33 34 36
  • 58.94 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NDPK1 33
  • 61.01 (n)
(Oryza sativa)
Liliopsida Os10g0563700 33
  • 63.29 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04202 33
  • 64.47 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ndk1 33
  • 54.67 (n)
Species where no ortholog for NME1-NME2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NME1-NME2 Gene

Gene Tree for NME1-NME2 (if available)
Gene Tree for NME1-NME2 (if available)

Paralogs for NME1-NME2 Gene

Paralogs for NME1-NME2 Gene

(6) SIMAP similar genes for NME1-NME2 Gene using alignment to 2 proteins: Pseudogenes for NME1-NME2 Gene

genes like me logo Genes that share paralogs with NME1-NME2: view

Variants for NME1-NME2 Gene

Sequence variations from dbSNP and Humsavar for NME1-NME2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000099463 -- 51,164,192(+) TCAGG(A/G)TGGGG intron-variant, upstream-variant-2KB
rs1000321303 -- 51,168,650(+) TGGGC(A/G)ACAGA intron-variant
rs1000422584 -- 51,168,503(+) CAGAC(C/G)TTAGA intron-variant
rs1000492510 -- 51,151,603(+) AAATA(A/C)ATAAA upstream-variant-2KB
rs1000530944 -- 51,156,408(+) TGGGT(A/G)AGGCA intron-variant

Variation tolerance for NME1-NME2 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME1-NME2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NME1-NME2 Gene

Disorders for NME1-NME2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NME1-NME2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bladder disease
  • urinary bladder disease
pain disorder
  • paine syndrome
radiation cystitis
  • irradiation cystitis
lung sarcoma
  • pulmonary sarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NME1-NME2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NME1-NME2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NME1-NME2 Gene

Publications for NME1-NME2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  2. Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV. (PMID: 16442775) Valentijn LJ … Versteeg R (Genomics 2006) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 60
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60

Products for NME1-NME2 Gene

Sources for NME1-NME2 Gene

Loading form....