Aliases for NME1-NME2 Gene
External Ids for NME1-NME2 Gene
Previous GeneCards Identifiers for NME1-NME2 Gene
This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]
GeneCards Summary for NME1-NME2 Gene
NME1-NME2 (NME1-NME2 Readthrough) is a Protein Coding gene. Diseases associated with NME1-NME2 include Bladder Disease and Radiation Cystitis. Among its related pathways are Purine metabolism and Pyrimidine metabolism (KEGG). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein histidine kinase activity. An important paralog of this gene is NME7.
UniProtKB/Swiss-Prot for NME1-NME2 Gene
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.