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Aliases for NME1-NME2 Gene

Aliases for NME1-NME2 Gene

  • NME1-NME2 Readthrough 2 3
  • NME1-NME2 Readthrough Transcript 3
  • NM23-LV 3
  • NMELV 3

External Ids for NME1-NME2 Gene

Previous GeneCards Identifiers for NME1-NME2 Gene

  • GC17U900586
  • GC17P046586
  • GC17P049230
  • GC17P044600

Summaries for NME1-NME2 Gene

Entrez Gene Summary for NME1-NME2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for NME1-NME2 Gene

NME1-NME2 (NME1-NME2 Readthrough) is a Protein Coding gene. Diseases associated with NME1-NME2 include chronic interstitial cystitis and radiation cystitis. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein histidine kinase activity. An important paralog of this gene is NME7.

Gene Wiki entry for NME1-NME2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME1-NME2 Gene

Genomics for NME1-NME2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NME1-NME2 Gene

Chromosome:
17
Start:
51,153,536 bp from pter
End:
51,171,747 bp from pter
Size:
18,212 bases
Orientation:
Plus strand

Genomic View for NME1-NME2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NME1-NME2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME1-NME2 Gene

No data available for Regulatory Elements for NME1-NME2 Gene

Proteins for NME1-NME2 Gene

  • Protein details for NME1-NME2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F6XY72
    Recommended name:
    HCG2001850, isoform CRA_c
    Protein Accession:
    F6XY72

    Protein attributes for NME1-NME2 Gene

    Size:
    82 amino acids
    Molecular mass:
    9583 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NME1-NME2 Gene

Proteomics data for NME1-NME2 Gene at MOPED

Post-translational modifications for NME1-NME2 Gene

No Post-translational modifications

Other Protein References for NME1-NME2 Gene

No data available for DME Specific Peptides for NME1-NME2 Gene

Domains & Families for NME1-NME2 Gene

Protein Domains for NME1-NME2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NME1-NME2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NME1-NME2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NME1-NME2 Gene

Function for NME1-NME2 Gene

Gene Ontology (GO) - Molecular Function for NME1-NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0005504 fatty acid binding --
GO:0005524 ATP binding --
GO:0008144 drug binding --
genes like me logo Genes that share ontologies with NME1-NME2: view

Phenotypes for NME1-NME2 Gene

genes like me logo Genes that share phenotypes with NME1-NME2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NME1-NME2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NME1-NME2 Gene

Localization for NME1-NME2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NME1-NME2 Gene COMPARTMENTS Subcellular localization image for NME1-NME2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 2
chloroplast 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NME1-NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament --
GO:0031966 mitochondrial membrane --
GO:0048471 perinuclear region of cytoplasm --
genes like me logo Genes that share ontologies with NME1-NME2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NME1-NME2 Gene

Pathways & Interactions for NME1-NME2 Gene

genes like me logo Genes that share pathways with NME1-NME2: view

Interacting Proteins for NME1-NME2 Gene

Gene Ontology (GO) - Biological Process for NME1-NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002762 negative regulation of myeloid leukocyte differentiation --
GO:0006165 nucleoside diphosphate phosphorylation --
GO:0006183 GTP biosynthetic process --
GO:0006228 UTP biosynthetic process --
GO:0006241 CTP biosynthetic process --
genes like me logo Genes that share ontologies with NME1-NME2: view

No data available for SIGNOR curated interactions for NME1-NME2 Gene

Drugs & Compounds for NME1-NME2 Gene

No Compound Related Data Available

Transcripts for NME1-NME2 Gene

mRNA/cDNA for NME1-NME2 Gene

(1) REFSEQ mRNAs :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NME1-NME2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME1-NME2 Gene

No ASD Table

Relevant External Links for NME1-NME2 Gene

GeneLoc Exon Structure for
NME1-NME2
ECgene alternative splicing isoforms for
NME1-NME2

Expression for NME1-NME2 Gene

mRNA expression in normal human tissues for NME1-NME2 Gene

Protein differential expression in normal tissues from HIPED for NME1-NME2 Gene

This gene is overexpressed in Saliva (16.3) and Brain (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb and MaxQB for NME1-NME2 Gene



genes like me logo Genes that share expression patterns with NME1-NME2: view

Protein tissue co-expression partners for NME1-NME2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NME1-NME2 Gene

Orthologs for NME1-NME2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME1-NME2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC101905864 35
  • 74.34 (n)
  • 71.68 (a)
NME2 36
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm5566 35
  • 89.47 (n)
  • 94.74 (a)
Gm5566 16
Gm20390 36
  • 97 (a)
ManyToMany
Gm4862 36
  • 73 (a)
ManyToMany
Nme2 36
  • 97 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC101059613 35
  • 96.35 (n)
  • 94.16 (a)
-- 36
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NME2 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NME2 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves NME1 36
  • 81 (a)
ManyToMany
NME2 36
  • 92 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nme2a 35
  • 71.36 (n)
  • 79.19 (a)
CABZ01038708.1 36
  • 61 (a)
ManyToMany
nme2a 36
  • 68 (a)
ManyToMany
nme2b.2 36
  • 78 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007120 35
  • 67.5 (n)
  • 70.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta awd 35
  • 69.28 (n)
  • 72.89 (a)
awd 36
  • 68 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ndk-1 35
  • 62.28 (n)
  • 69.08 (a)
ndk-1 36
  • 68 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR096C 35
  • 59.91 (n)
  • 60.81 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03696g 35
  • 60.96 (n)
  • 64.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 35
  • 58.94 (n)
  • 60.26 (a)
YNK1 36
  • 60 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NDPK1 35
  • 61.01 (n)
  • 59.12 (a)
rice
(Oryza sativa)
Liliopsida Os10g0563700 35
  • 63.29 (n)
  • 61.49 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04202 35
  • 64.47 (n)
  • 63.16 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ndk1 35
  • 54.67 (n)
  • 56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToMany
Species with no ortholog for NME1-NME2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NME1-NME2 Gene

ENSEMBL:
Gene Tree for NME1-NME2 (if available)
TreeFam:
Gene Tree for NME1-NME2 (if available)

Paralogs for NME1-NME2 Gene

Paralogs for NME1-NME2 Gene

(6) SIMAP similar genes for NME1-NME2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NME1-NME2 Gene

genes like me logo Genes that share paralogs with NME1-NME2: view

Variants for NME1-NME2 Gene

Sequence variations from dbSNP and Humsavar for NME1-NME2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs183104471 -- 51,163,039(+) TGAGA(A/C)CAGCC intron-variant
rs371644418 -- 51,162,598(+) TAGTC(C/T)TAGCT intron-variant
rs373252894 -- 51,163,062(+) TGAGA(A/C)CTCAT intron-variant
rs536738758 -- 51,151,540(+) GATCC(A/G)CCAAG upstream-variant-2KB
rs537957936 -- 51,163,072(+) TCTCT(G/T)CCAAA intron-variant

Variation tolerance for NME1-NME2 Gene

Residual Variation Intolerance Score: 66.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME1-NME2 Gene

HapMap Linkage Disequilibrium report
NME1-NME2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NME1-NME2 Gene

Disorders for NME1-NME2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NME1-NME2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic interstitial cystitis
  • chronic interstitial cystitis [ambiguous]
radiation cystitis
  • irradiation cystitis
bladder disease
  • urinary bladder disease
lung sarcoma
  • pulmonary sarcoma
- elite association

Relevant External Links for NME1-NME2

Genetic Association Database (GAD)
NME1-NME2
Human Genome Epidemiology (HuGE) Navigator
NME1-NME2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NME1-NME2
genes like me logo Genes that share disorders with NME1-NME2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NME1-NME2 Gene

Publications for NME1-NME2 Gene

  1. Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV. (PMID: 16442775) Valentijn L.J. … Versteeg R. (Genomics 2006) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 67
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 67

Products for NME1-NME2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NME1-NME2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for NME1-NME2
  • Block miRNA regulation of NME1-NME2 using miScript Target Protectors

Sources for NME1-NME2 Gene

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