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Aliases for NME1-NME2 Gene

Aliases for NME1-NME2 Gene

  • NME1-NME2 Readthrough 2 3 5
  • EC 2.7.4.6 4 63
  • C-Myc Purine-Binding Transcription Factor PUF 4
  • NME1-NME2 Readthrough Transcript 3
  • Histidine Protein Kinase NDKB 4
  • NDP Kinase B 4
  • EC 2.7.13.3 4
  • NM23-LV 3
  • Nm23-H2 4
  • NMELV 3
  • NDK B 4
  • NM23B 4
  • NME2 4

External Ids for NME1-NME2 Gene

Previous GeneCards Identifiers for NME1-NME2 Gene

  • GC17U900586
  • GC17P046586
  • GC17P049230
  • GC17P044600

Summaries for NME1-NME2 Gene

Entrez Gene Summary for NME1-NME2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for NME1-NME2 Gene

NME1-NME2 (NME1-NME2 Readthrough) is a Protein Coding gene. Diseases associated with NME1-NME2 include bladder disease and radiation cystitis. Among its related pathways are Metabolism and Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein histidine kinase activity. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME1-NME2 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

Gene Wiki entry for NME1-NME2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME1-NME2 Gene

Genomics for NME1-NME2 Gene

Regulatory Elements for NME1-NME2 Gene

Promoters for NME1-NME2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NME1-NME2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NME1-NME2 Gene

Chromosome:
17
Start:
51,153,536 bp from pter
End:
51,171,744 bp from pter
Size:
18,209 bases
Orientation:
Plus strand

Genomic View for NME1-NME2 Gene

Genes around NME1-NME2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME1-NME2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME1-NME2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME1-NME2 Gene

Proteins for NME1-NME2 Gene

  • Protein details for NME1-NME2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22392-NDKB_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase B
    Protein Accession:
    P22392
    Secondary Accessions:
    • A8MWA3
    • Q1WM23
    • Q6LCT6

    Protein attributes for NME1-NME2 Gene

    Size:
    152 amino acids
    Molecular mass:
    17298 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8 (By similarity). Interacts with AKAP13. Interacts ITGB1BP1 (via C-terminal domain region).
    • Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8 (By similarity). Interacts with AKAP13. Interacts ITGB1BP1 (via C-terminal domain region).

    Three dimensional structures from OCA and Proteopedia for NME1-NME2 Gene

    Alternative splice isoforms for NME1-NME2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NME1-NME2 Gene

Proteomics data for NME1-NME2 Gene at MOPED

Post-translational modifications for NME1-NME2 Gene

  • Ubiquitination at Lys 39
  • Modification sites at PhosphoSitePlus

Other Protein References for NME1-NME2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NME1-NME2 Gene

Protein Domains for NME1-NME2 Gene

Suggested Antigen Peptide Sequences for NME1-NME2 Gene

Graphical View of Domain Structure for InterPro Entry

P22392

UniProtKB/Swiss-Prot:

NDKB_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME1-NME2: view

No data available for Gene Families for NME1-NME2 Gene

Function for NME1-NME2 Gene

Molecular function for NME1-NME2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

Enzyme Numbers (IUBMB) for NME1-NME2 Gene

Gene Ontology (GO) - Molecular Function for NME1-NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NME1-NME2: view
genes like me logo Genes that share phenotypes with NME1-NME2: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NME1-NME2 Gene

Localization for NME1-NME2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NME1-NME2 Gene

Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 3 is mainly cytoplasmic and isoform 1 and isoform 3 are excluded from the nucleolus. Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. {ECO:0000269 PubMed:11919189, ECO:0000269 PubMed:16442775}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NME1-NME2 Gene COMPARTMENTS Subcellular localization image for NME1-NME2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
cytoskeleton 2
mitochondrion 2
plasma membrane 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for NME1-NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NME1-NME2: view

Pathways & Interactions for NME1-NME2 Gene

genes like me logo Genes that share pathways with NME1-NME2: view

Gene Ontology (GO) - Biological Process for NME1-NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006163 purine nucleotide metabolic process IBA --
GO:0006220 pyrimidine nucleotide metabolic process IBA --
GO:0006241 CTP biosynthetic process IEA --
GO:0007229 integrin-mediated signaling pathway IDA --
GO:0015949 nucleobase-containing small molecule interconversion TAS --
genes like me logo Genes that share ontologies with NME1-NME2: view

No data available for SIGNOR curated interactions for NME1-NME2 Gene

Drugs & Compounds for NME1-NME2 Gene

No Compound Related Data Available

Transcripts for NME1-NME2 Gene

mRNA/cDNA for NME1-NME2 Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NME1-NME2 Gene

No ASD Table

Relevant External Links for NME1-NME2 Gene

GeneLoc Exon Structure for
NME1-NME2
ECgene alternative splicing isoforms for
NME1-NME2

Expression for NME1-NME2 Gene

mRNA expression in normal human tissues for NME1-NME2 Gene

Protein differential expression in normal tissues from HIPED for NME1-NME2 Gene

This gene is overexpressed in Saliva (16.3) and Brain (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NME1-NME2 Gene



mRNA Expression by UniProt/SwissProt for NME1-NME2 Gene

P22392-NDKB_HUMAN
Tissue specificity: Isoform 1 and isoform 3 are ubiquitously expressed.
genes like me logo Genes that share expression patterns with NME1-NME2: view

Protein tissue co-expression partners for NME1-NME2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NME1-NME2 Gene

Orthologs for NME1-NME2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME1-NME2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 92 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
LOC101059613 35
  • 96.35 (n)
  • 94.16 (a)
cow
(Bos Taurus)
Mammalia NME2 36
  • 96 (a)
OneToMany
LOC101905864 35
  • 74.34 (n)
  • 71.68 (a)
mouse
(Mus musculus)
Mammalia Gm20390 36
  • 97 (a)
ManyToMany
Nme2 36
  • 97 (a)
ManyToMany
Gm5566 16
Gm5566 35
  • 89.47 (n)
  • 94.74 (a)
oppossum
(Monodelphis domestica)
Mammalia NME2 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NME2 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves NME1 36
  • 81 (a)
ManyToMany
NME2 36
  • 92 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01038708.1 36
  • 61 (a)
ManyToMany
nme2a 36
  • 68 (a)
ManyToMany
nme2b.2 36
  • 78 (a)
ManyToMany
nme2a 35
  • 71.36 (n)
  • 79.19 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007120 35
  • 67.5 (n)
  • 70.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta awd 36
  • 68 (a)
OneToMany
awd 35
  • 69.28 (n)
  • 72.89 (a)
worm
(Caenorhabditis elegans)
Secernentea ndk-1 35
  • 62.28 (n)
  • 69.08 (a)
ndk-1 36
  • 68 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR096C 35
  • 59.91 (n)
  • 60.81 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 35
  • 58.94 (n)
  • 60.26 (a)
YNK1 36
  • 60 (a)
OneToMany
YNK1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03696g 35
  • 60.96 (n)
  • 64.47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NDPK1 35
  • 61.01 (n)
  • 59.12 (a)
rice
(Oryza sativa)
Liliopsida Os10g0563700 35
  • 63.29 (n)
  • 61.49 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04202 35
  • 64.47 (n)
  • 63.16 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ndk1 35
  • 54.67 (n)
  • 56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToMany
Species with no ortholog for NME1-NME2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NME1-NME2 Gene

ENSEMBL:
Gene Tree for NME1-NME2 (if available)
TreeFam:
Gene Tree for NME1-NME2 (if available)

Paralogs for NME1-NME2 Gene

Paralogs for NME1-NME2 Gene

(6) SIMAP similar genes for NME1-NME2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NME1-NME2 Gene

genes like me logo Genes that share paralogs with NME1-NME2: view

Variants for NME1-NME2 Gene

Sequence variations from dbSNP and Humsavar for NME1-NME2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs80075032 -- 51,162,638(+) CCCAG(C/G)AGTCC intron-variant
rs146103292 -- 51,162,719(+) AAAAA(C/T)ATATC intron-variant
rs183104471 -- 51,163,039(+) TGAGA(A/C)CAGCC intron-variant
rs536738758 -- 51,151,540(+) GATCC(A/G)CCAAG upstream-variant-2KB
rs371644418 -- 51,162,598(+) TAGTC(C/T)TAGCT intron-variant

Variation tolerance for NME1-NME2 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME1-NME2 Gene

HapMap Linkage Disequilibrium report
NME1-NME2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NME1-NME2 Gene

Disorders for NME1-NME2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NME1-NME2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bladder disease
  • urinary bladder disease
radiation cystitis
  • irradiation cystitis
lung sarcoma
  • pulmonary sarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NME1-NME2

Genetic Association Database (GAD)
NME1-NME2
Human Genome Epidemiology (HuGE) Navigator
NME1-NME2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NME1-NME2
genes like me logo Genes that share disorders with NME1-NME2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NME1-NME2 Gene

Publications for NME1-NME2 Gene

  1. Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV. (PMID: 16442775) Valentijn L.J. … Versteeg R. (Genomics 2006) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Plakoglobin interacts with and increases the protein levels of metastasis suppressor Nm23-H2 and regulates the expression of Nm23-H1. (PMID: 20101217) Aktary Z. … Pasdar M. (Oncogene 2010) 3

Products for NME1-NME2 Gene

Sources for NME1-NME2 Gene

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