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NME1 Gene

protein-coding   GIFtS: 66
GCID: GC17P049231

NME/NM23 Nucleoside Diphosphate Kinase 1

(Previous names: non-metastatic cells 1, protein (NM23A) expressed in)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NME/NM23 Nucleoside Diphosphate Kinase 11 2     AWD2
NM232 3 5     NB2
Non-Metastatic Cells 1, Protein (NM23A) Expressed In1 2     NBS2
Granzyme A-Activated DNase2 3     NDKA2
Metastasis Inhibition Factor Nm232 3     NDPK-A2
Tumor Metastatic Process-Associated Protein2 3     NM23-H12
GAAD2 3     Nucleoside Diphosphate Kinase A2
NDPKA2 3     NDK A3
NDP Kinase A2 3     nm23-H13
EC 2.7.4.63 8     

External Ids:    HGNC: 78491   Entrez Gene: 48302   Ensembl: ENSG000002396727   OMIM: 1564905   UniProtKB: P155313   

Export aliases for NME1 gene to outside databases

Previous GC identifers: GC17P048944 GC17P051712 GC17P049572 GC17P049705 GC17P046585 GC17P044601


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NME1 Gene:
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells.
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded
by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript
variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the
neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion
protein comprised of sequence sharing identity with each individual gene product. (provided by RefSeq, Jul 2008)

GeneCards Summary for NME1 Gene:
NME1 (NME/NM23 nucleoside diphosphate kinase 1) is a protein-coding gene. Diseases associated with NME1 include neuroblastoma, and laryngeal carcinoma. GO annotations related to this gene include protein kinase binding and identical protein binding. An important paralog of this gene is NME2.

UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate
kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein
kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal
transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development
including neural patterning and cell fate determination

Gene Wiki entry for NME1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NME1 gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NME1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NME1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

NME1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P049231:  view genomic region     (about GC identifiers)

Start:
49,230,897 bp from pter      End:
49,239,789 bp from pter
Size:
8,893 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531 (See protein sequence)
Recommended Name: Nucleoside diphosphate kinase A  
Size: 152 amino acids; 17149 Da
Cofactor: Magnesium
Subunit: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with SET and
PRUNE
Miscellaneous: The role of this protein in tumor development and progression is uncertain. This protein is found
in reduced amount in some tumor cells of high metastatic potential. However, increased NME1 levels correlate with
aggressive tumor features in neuroblastoma. May have distinct if not opposite roles in different tumors
Sequence caution: Sequence=CAA35621.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6 PDB 3D structures from and Proteopedia for NME1:
1JXV (3D)        1UCN (3D)        2HVD (3D)        2HVE (3D)        3L7U (3D)        4ENO (3D)    
Secondary accessions: Q6FGK3 Q86XQ2 Q9UDJ6
Alternative splicing: 3 isoforms:  P15531-1   P15531-2   P22392-2   (Based on a naturally occurring readthrough transcript which produces an NME1-NME2 fusion protein)

Explore the universe of human proteins at neXtProt for NME1: NX_P15531

Explore proteomics data for NME1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys12, Lys26, Lys49, Lys56, Lys100
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NME1 (P15531) (see all 10)
     PGTIRGD  RFEQKGF  NIIHGSD  ASEDLLK 


    See NME1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000260.1  NP_937818.1  

    ENSEMBL proteins: 
     ENSP00000376892   ENSP00000337060   ENSP00000429318   ENSP00000428553   ENSP00000435498  
     ENSP00000013034   ENSP00000387682  
    Reactome Protein details: P15531

    NME1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for NME1
    OriGene Protein Over-expression Lysate for NME1
    OriGene MassSpec for NME1
    OriGene Custom Protein Services for NME1
    GenScript Custom Purified and Recombinant Proteins Services for NME1
    Novus Biologicals NME1 Proteins
    Novus Biologicals NME1 Lysates
    Sino Biological Recombinant Protein for NME1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NME1
    Cloud-Clone Corp. Proteins for NME1

    NME1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NME1
    R&D Systems Antibodies for NME1 (NM23-H1/H2, NM23-H1)
    Cell Signaling Technology (CST) Antibodies for NME1 
    OriGene Antibodies for NME1
    OriGene Custom Antibody Services for NME1
    Novus Biologicals NME1 Antibodies
    Abcam antibodies for NME1
    Cloud-Clone Corp. Antibodies for NME1
    ThermoFisher Antibody for NME1
    LSBio Antibodies in human, mouse, rat for NME1

    NME1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NME1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NME1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NME1
    Cloud-Clone Corp. CLIAs for NME1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR023005 Nucleoside_diP_kinase_AS
     IPR001564 Nucleoside_diP_kinase

    Graphical View of Domain Structure for InterPro Entry P15531

    ProtoNet protein and cluster: P15531

    1 Blocks protein domain: IPB001564 Nucleoside diphosphate kinase

    UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531
    Similarity: Belongs to the NDK family


    NME1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDKA_HUMAN, P15531
    Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate
    kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein
    kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal
    transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development
    including neural patterning and cell fate determination
    Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
    Enzyme regulation: Autophosphorylation at His-118 increases serine/threonine protein kinase activity of the
    enzyme. Interaction with the SET complex inhibits exonuclease activity

         Genatlas biochemistry entry for NME1:
    non-metastatic cells 1,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the
    phosphorylation of nucleoside diphosphates,with a reduced expression in tumor progression to the metastatic
    phenotype,mutated in agressive neuroblastoma,expressed in lung carcinoma cell lines not in normal lung,pyrimidine
    biosynthetic pathway

         Enzyme Number (IUBMB): EC 2.7.4.61 2

         Gene Ontology (GO): Selected molecular function terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA11555662
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IEA--
    GO:0003697single-stranded DNA binding IEA--
    GO:0004536deoxyribonuclease activity IDA11555662
    GO:0004550nucleoside diphosphate kinase activity IDA12972261
         
    NME1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NME1:
     Decreased melanin production  Increased mitotic index 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nme1):
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     integument  liver/biliary system  mortality/aging  nervous system  other 
     tumorigenesis 

    NME1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nme1/Nme2Nme1/tm1Zou for NME1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NME1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NME1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NME1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NME1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NME1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NME1:
    hsa-miR-141 hsa-miR-200a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NME1
    Predesigned siRNA for gene silencing in human, mouse, rat NME1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NME1

    Clone
    Products:
         
    OriGene clones in human, mouse for NME1 (see all 11)
    OriGene ORF clones in mouse, rat for NME1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NME1 (NM_000269)
    Sino Biological Human cDNA Clone for NME1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NME1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NME1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDKA_HUMAN, P15531: Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by
    interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane3
    cytoskeleton2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS16130169
    GO:0005737cytoplasm TAS16130169
    GO:0005739mitochondrion IEA--
    GO:0005813centrosome IEA--
    GO:0005829cytosol TAS--

    NME1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NME1 About   (see all 20)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    Pyrimidine metabolism0.38
    purine deoxyribonucleosides salvage0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
    adenosine deoxyribonucleotides de novo biosynthesis0.00
    guanosine deoxyribonucleotides de novo biosynthesis0.52
    pyrimidine deoxyribonucleotides de novo biosynthesis0.00
    superpathway of pyrimidine deoxyribonucleoside salvage0.46
    UTP and CTP de novo biosynthesis0.00
    CMP phosphorylation0.00
    superpathway of pyrimidine ribonucleotides de novo biosynthesis0.00
    4purine nucleotide salvage
    purine nucleotide salvage0.78
    guanosine nucleotides de novo biosynthesis0.00
    purine nucleotides de novo biosynthesis0.78
    guanosine ribonucleotides de novo biosynthesis0.00
    5Purine metabolism (REACTOME)
    Metabolism of nucleotides0.42
    Synthesis and interconversion of nucleotide di- and triphosphates0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NME1
        Granzyme-A Pathway
    Remodeling of Adherens Junctions
    Granzyme Pathway

    1 Cell Signaling Technology (CST) Pathway for NME1
        Translational Control

    1 GeneGo (Thomson Reuters) Pathway for NME1
        ATP/ITP metabolism

    Selected BioSystems Pathways for NME1 (see all 22)
        purine nucleotides de novo biosynthesis
    superpathway of pyrimidine ribonucleotides de novo biosynthesis
    purine deoxyribonucleosides salvage
    Integrated Pancreatic Cancer Pathway
    guanosine nucleotides de novo biosynthesis


    1 Reactome Pathway for NME1
        Synthesis and interconversion of nucleotide di- and triphosphates

    4 PharmGKB Pathways for NME1
        Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
    Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Tenofovir/Adefovir Pathway, Pharmacokinetics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

    3 Kegg Pathways  (Kegg details for NME1):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways


    NME1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NME1: 
              Adherens Junctions in human mouse rat
              Breast Cancer in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NME1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NME1 (P155311, 2, 3 ENSP000000130344) via UniProtKB, MINT, STRING, and/or I2D (see all 201)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME2P223921, 3, ENSP000003655724EBI-741141,EBI-713693 I2D: score=2 STRING: ENSP00000365572
    NME3Q132322, 3, ENSP000002193024MINT-68402 I2D: score=6 STRING: ENSP00000219302
    TERF1P542742, 3, ENSP000002766034MINT-17759 I2D: score=4 STRING: ENSP00000276603
    NME1-NME2P223921, 3EBI-741141,EBI-713693 I2D: score=2 
    STRAPQ9Y3F41, 3, ENSP000003922704EBI-741141,EBI-727414 I2D: score=2 STRING: ENSP00000392270
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002762negative regulation of myeloid leukocyte differentiation IEA--
    GO:0006165nucleoside diphosphate phosphorylation ----
    GO:0006183GTP biosynthetic process IEA--
    GO:0006228UTP biosynthetic process IEA--
    GO:0006241CTP biosynthetic process IEA--

    NME1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NME1 (NDKA)

    Selected HMDB Compounds for NME1 (see all 21)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2'-Deoxyinosine triphosphate2'-Deoxyinosine-5'-triphosphate (see all 6)16595-02-1--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CDPCDP (see all 3)63-38-7--
    Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--
    Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--

    Selected DrugBank Compounds for NME1 (see all 16)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate-- --target--17139284 17016423 10592235
    2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate-- --target--17139284 17016423 10592235
    2'-Deoxyguanosine-5'-Diphosphate-- --target--17139284 17016423 10592235
    2'-Deoxyguanosine-5'-Triphosphate-- 2564-35-4target--17139284 17016423 10592235
    3'-Azido-3'-Deoxythymidine-5'-Diphosphate-- --target--17139284 17016423 10592235
    3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate-- --target--17139284 17016423 10592235
    Adenosine Phosphonoacetic Acid-- --target--17139284 17016423 10592235
    Fudp-- --target--17139284 17016423 10592235
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235
    Pyrophosphate 2--- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for NME1 gene (see all 52)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphohistidine 51.3 1 19415463 (1)
    histidine 38.8 19 10698688 (3), 12105213 (3), 9038158 (2), 12848344 (1) (see all 12)
    paraffin 36.8 9 8386774 (1), 15190803 (1), 9888669 (1), 11855920 (1) (see all 9)
    diphosphates 36 2 11343655 (1), 8245015 (1)
    vegf 36 70 15604068 (7), 12761948 (6), 12768677 (5), 17283532 (5) (see all 22)
    slex 30.6 23 9663428 (7), 15269984 (5), 8641989 (4)
    17-(allylamino)-17-demethoxygeldanamycin 27.9 4 15684389 (1), 17022645 (1)
    crcs 25.4 2 12883690 (1)
    bgl ii 21.5 2 1377015 (1), 1684428 (1)
    gtp 21.4 12 12145286 (2), 10611312 (2), 18470881 (1), 10082974 (1)



    NME1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NME1 gene (2 alternative transcripts): 
    NM_000269.2  NM_198175.1  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393196(uc002iti.2) ENST00000487481 ENST00000336097(uc002ith.2)
    ENST00000480143 ENST00000512768(uc010dbx.2) ENST00000511355 ENST00000475573
    ENST00000013034 ENST00000456492 ENST00000465188
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NME1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NME1:
    hsa-miR-141 hsa-miR-200a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NME1
    Predesigned siRNA for gene silencing in human, mouse, rat NME1
    Clone
    Products:
         
    OriGene clones in human, mouse for NME1 (see all 11)
    OriGene ORF clones in mouse, rat for NME1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NME1 (NM_000269)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NME1
    OriGene qSTAR qPCR primer pairs in human, mouse for NME1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NME1
      QuantiTect SYBR Green Assays in human, mouse, rat NME1
      QuantiFast Probe-based Assays in human, mouse, rat NME1

    Selected AceView cDNA sequences (see all 233):

    BQ678803 BM846125 CB119276 AI708633 BE910053 CR610816 CR621859 BQ217266 
    BQ897114 CB121817 BU186842 AA961037 BU935397 CD109158 BM788131 AU132603 
    BI753048 BU956983 BE396402 BM765413 BE779880 BX421668 BE253974 BU557164 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NME1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NME1 Expression
    About this image


    NME1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Lung (Respiratory System)
             Trachea
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
    NME1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NME1 Protein Expression

    UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531
    Tissue specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas,
    spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is
    ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously
    expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NME1: 
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              Breast Cancer in human mouse rat
              Tumor Metastasis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NME1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nme11 , 5 non-metastatic cells 1, protein (NM23A) expressed in5
    NME/NM23 nucleoside diphosphate kinase 11
    87.72(n)1
    94.08(a)1
      11 (58.89 cM)5
    181021  NM_008704.21  NP_032730.11 
     939569795 
    chicken
    (Gallus gallus)
    Aves NME11 non-metastatic cells 1, protein (NM23A) expressed in 75.68(n)
    84.46(a)
      422094  NM_001204761.1  NP_001191690.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Nucleoside diphosphate kinase
    49(a)
    1 → many
    2(117749525-117771891)
    zebrafish
    (Danio rerio)
    Actinopterygii nme2b.11 NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate more 77.48(n)
    84.77(a)
      30083  NM_130926.1  NP_571001.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta awd3 CTP biosynthesis nucleoside-diphosphate
    kinase
    77(a)   100D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea F25H2.53 nucleoside diphosphate kinase 66(a)   I(10561041-10562106)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YNK16
    Nucleoside diphosphate kinase, catalyzes the trans...
    59(a)
    1 → many
    XI(314812-315273) YKL067W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G238951 AT4G23895 63.56(n)
    64(a)
      2745723  NM_001203888.1  NP_001190817.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05954001 Os05g0595400 60.89(n)
    62.67(a)
      4339815  NM_001063050.1  NP_001056515.1 


    ENSEMBL Gene Tree for NME1 (if available)
    TreeFam Gene Tree for NME1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NME1 gene
    NME22  NME32  NME82  NME42  NME72  NME1-NME22  NME62  NME92  
    NME52  
    7 SIMAP similar genes for NME1 using alignment to 4 protein entries:     NDKA_HUMAN (see all proteins):
    NME1-NME2    NME2    NME3    NME2P1    c371H6.2    NME4
    NME7

    NME1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NME1
    PGOHUM00000248324 PGOHUM00000248523


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NME1 (see all 224)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219178871,2,,4
    Cuntested150253292(+) ATGGCA/GGTGAT 4 S G mis10--------
    rs1466255301,2
    --50243161(+) TAAAGA/GCCGAG 2 -- us2k10--------
    rs1917538931,2
    --50243170(+) AGCACG/TGTGGC 2 -- us2k10--------
    rs23187831,2
    --50243339(+) tttggA/Gaggct 2 -- us2k10--------
    rs75024501,2
    C--50243472(+) ctcggA/Gaggct 2 -- us2k10--------
    rs288805791,2
    C--50243596(+) AAAAAA/GAAAAA 2 -- us2k11Minor allele frequency- G:0.00WA 2
    rs567570471,2
    C--50243596(+) AAAAA-/G/GAA 
            
    AAAGA
    4 -- us2k1 cds10--------
    rs1874473411,2
    --50243622(+) GGTGGC/GAGACG 2 -- us2k10--------
    rs1929330961,2
    --50243667(+) GAGAAA/TCGCTT 2 -- us2k10--------
    rs1855254081,2
    --50243837(+) AGTCTA/CGCTCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for NME1 (49230897 - 49239789 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NME1: --
    Human Gene Mutation Database (HGMD): NME1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NME1
    DNA2.0 Custom Variant and Variant Library Synthesis for NME1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 156490   
    OMIM disorders: 256700  
    Selected diseases for NME1 (see all 111):    
    About MalaCards
    neuroblastoma    laryngeal carcinoma    acute monocytic leukemia    skin melanoma
    metaphyseal dysplasia without hypotrichosis    alk-related neuroblastoma susceptibility    cartilage-hair hypoplasia - anauxetic dysplasia spectrum disorders    soft tissue sarcoma
    laryngitis    gallbladder adenocarcinoma    anal canal carcinoma    lung giant cell carcinoma
    cartilage-hair hypoplasia    anauxetic dysplasia    brain glioma    cervical intraepithelial neoplasia
    keratoacanthoma    cervical adenocarcinoma    malignant hyperthermia susceptibility    laryngeal squamous cell carcinoma


    NME1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for NME1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 84.6 965 11289754 (7), 8418304 (6), 11179491 (6), 16739379 (6) (see all 99)
    tumors 70.7 732 7745027 (6), 10424391 (6), 9874452 (5), 8199988 (5) (see all 99)
    breast carcinoma 69.7 90 9070493 (5), 11280805 (3), 11866905 (3), 7990158 (3) (see all 58)
    carcinoma 60.7 144 18996649 (5), 10523705 (3), 9570214 (3), 10914829 (3) (see all 78)
    melanoma 60.6 161 8912348 (6), 9167178 (5), 17696918 (5), 7829217 (5) (see all 63)
    ductal breast carcinoma 59.7 4 8386774 (1), 17642161 (1), 9042324 (1), 8912348 (1)
    colorectal carcinoma 59.4 71 11289754 (9), 16078572 (5), 8199988 (4), 7774480 (4) (see all 27)
    primary tumor 59.4 54 11268486 (4), 9143023 (3), 9949298 (3), 9194030 (3) (see all 29)
    large cell lung cancer 58.2 4 17167724 (1), 18440302 (1), 15757527 (1)
    cancer 57.4 147 8931974 (4), 10794547 (3), 16425351 (3), 10403689 (3) (see all 99)

    Genetic Association Database (GAD): NME1
    Human Genome Epidemiology (HuGE) Navigator: NME1 (7 documents)
    Tumor Gene Database (TGDB): NME1

    Export disorders for NME1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NME1 gene, integrated from 10 sources (see all 883):
    (articles sorted by number of sources associating them with NME1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. (PubMed id 8270257)1, 2, 3, 9 Dooley S.... Welter C. (Hum. Genet. 1994)
    2. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL- mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. (PubMed id 12628186)1, 2, 9 Fan Z.... Lieberman J. (Cell 2003)
    3. High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification. (PubMed id 2056128)1, 2, 9 Hailat N.... Hanash S.J. (J. Clin. Invest. 1991)
    4. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. (PubMed id 10512675)1, 2, 9 Manda R.... Yokota J. (Genomics 1999)
    5. Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells. (PubMed id 8810265)1, 2, 9 MacDonald N.J.... Steeg P.S. (J. Biol. Chem. 1996)
    6. Mutation in the nm23 gene is associated with metastasis in colorectal cancer. (PubMed id 7916650)1, 2, 9 Wang L.... Banerjee S. (Cancer Res. 1993)
    7. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    8. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    9. Significant association of genetic polymorphism of human nonmetastatic clone 23 type 1 gene with an increased risk of endometrial cancer. (PubMed id 20599259)1, 4 Wang P.H....Yang S.F. (Gynecol. Oncol. 2010)
    10. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PubMed id 19183483)1, 4 Haiman C.A....Press M.F. (BMC Cancer 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4830 HGNC: 7849 AceView: NME1andNME2 Ensembl:ENSG00000239672 euGenes: HUgn4830
    ECgene: NME1 Kegg: 4830 H-InvDB: NME1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NME1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NME1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NME1 gene:
    Search GeneIP for patents involving NME1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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