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Aliases for NME1 Gene

Aliases for NME1 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 1 2 3
  • Non-Metastatic Cells 1, Protein (NM23A) Expressed In 2 3
  • Tumor Metastatic Process-Associated Protein 3 4
  • Metastasis Inhibition Factor Nm23 3 4
  • Granzyme A-Activated DNase 3 4
  • NDP Kinase A 3 4
  • EC 2.7.4.6 4 63
  • NM23-H1 3 4
  • NDPKA 3 4
  • GAAD 3 4
  • NM23 3 4
  • NDPK-A 3
  • NDK A 4
  • NDKA 3
  • AWD 3
  • NBS 3
  • NB 3

External Ids for NME1 Gene

Previous GeneCards Identifiers for NME1 Gene

  • GC17P048944
  • GC17P051712
  • GC17P049572
  • GC17P049705
  • GC17P046585
  • GC17P049231
  • GC17P044601

Summaries for NME1 Gene

Entrez Gene Summary for NME1 Gene

  • This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]

GeneCards Summary for NME1 Gene

NME1 (NME/NM23 Nucleoside Diphosphate Kinase 1) is a Protein Coding gene. Diseases associated with NME1 include anal canal carcinoma and laryngeal carcinoma. Among its related pathways are Integrated Pancreatic Cancer Pathway and Metabolism. GO annotations related to this gene include poly(A) RNA binding and GTP binding. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME1 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3-5 exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3 end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

Gene Wiki entry for NME1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME1 Gene

Genomics for NME1 Gene

Regulatory Elements for NME1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NME1 Gene

Chromosome:
17
Start:
51,153,536 bp from pter
End:
51,162,428 bp from pter
Size:
8,893 bases
Orientation:
Plus strand

Genomic View for NME1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NME1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME1 Gene

Proteins for NME1 Gene

  • Protein details for NME1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15531-NDKA_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase A
    Protein Accession:
    P15531
    Secondary Accessions:
    • Q6FGK3
    • Q86XQ2
    • Q9UDJ6

    Protein attributes for NME1 Gene

    Size:
    152 amino acids
    Molecular mass:
    17149 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with PRUNE. Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Within this complex, interacts directly with SET. Also interacts with TREX1, but only following translocation to the nucleus.
    Miscellaneous:
    • The role of this protein in tumor development and progression is uncertain. This protein is found in reduced amount in some tumor cells of high metastatic potential. However, increased NME1 levels correlate with aggressive tumor features in neuroblastoma. May have distinct if not opposite roles in different tumors
    SequenceCaution:
    • Sequence=CAA35621.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NME1 Gene

    Alternative splice isoforms for NME1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NME1 Gene

Proteomics data for NME1 Gene at MOPED

Post-translational modifications for NME1 Gene

  • Ubiquitination at Lys 100
  • Modification sites at PhosphoSitePlus

Domains & Families for NME1 Gene

Gene Families for NME1 Gene

Protein Domains for NME1 Gene

Suggested Antigen Peptide Sequences for NME1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15531

UniProtKB/Swiss-Prot:

NDKA_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME1: view

Function for NME1 Gene

Molecular function for NME1 Gene

GENATLAS Biochemistry:
non-metastatic cells 1,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of nucleoside diphosphates,with a reduced expression in tumor progression to the metastatic phenotype,mutated in agressive neuroblastoma,expressed in lung carcinoma cell lines not in normal lung,pyrimidine biosynthetic pathway
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Autophosphorylation at His-118 increases serine/threonine protein kinase activity of the enzyme. Interaction with the SET complex inhibits the endonuclease activity.
UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3-5 exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3 end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

Enzyme Numbers (IUBMB) for NME1 Gene

Gene Ontology (GO) - Molecular Function for NME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 11555662
GO:0004536 deoxyribonuclease activity IDA 11555662
GO:0004550 nucleoside diphosphate kinase activity IDA 12972261
GO:0005515 protein binding IPI 10602478
GO:0005524 ATP binding IDA 12972261
genes like me logo Genes that share ontologies with NME1: view
genes like me logo Genes that share phenotypes with NME1: view

Animal Models for NME1 Gene

MGI Knock Outs for NME1:

Animal Model Products

miRNA for NME1 Gene

miRTarBase miRNAs that target NME1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NME1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for NME1 Gene

Localization for NME1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NME1 Gene

Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NME1 Gene COMPARTMENTS Subcellular localization image for NME1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005634 nucleus TAS 16130169
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NME1: view

Pathways & Interactions for NME1 Gene

genes like me logo Genes that share pathways with NME1: view

PCR Array Products

SIGNOR curated interactions for NME1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006163 purine nucleotide metabolic process IBA --
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006220 pyrimidine nucleotide metabolic process IBA --
GO:0006228 UTP biosynthetic process IEA --
genes like me logo Genes that share ontologies with NME1: view

Drugs & Compounds for NME1 Gene

(45) Drugs for NME1 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adefovir Dipivoxil Approved, Investigational Pharma Enzyme, substrate 128
Lamivudine Approved, Investigational Pharma Enzyme, substrate Nucleoside analog reverse transcriptase inhibitor 575
Tenofovir Approved, Investigational Pharma Enzyme, substrate HIV reverse transcriptase inhibitor 636
Adenosine triphosphate Approved Nutra 0
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437

(41) Additional Compounds for NME1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
2'-Deoxyinosine triphosphate
  • 2'-Deoxy-Inosine 5'-(tetrahydrogen triphosphate)
  • 2'-Deoxyinosine-5'-triphosphate
  • 2'-Ditp
  • Deoxyinosine 5'-triphosphate
  • Deoxyinosine triphosphate
16595-02-1
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
1173-82-6
genes like me logo Genes that share compounds with NME1: view

Transcripts for NME1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NME1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME1 Gene

No ASD Table

Relevant External Links for NME1 Gene

GeneLoc Exon Structure for
NME1
ECgene alternative splicing isoforms for
NME1

Expression for NME1 Gene

mRNA expression in normal human tissues for NME1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NME1 Gene

This gene is overexpressed in Amniocyte (10.9), Lavage (6.5), and Liver, secretome (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NME1 Gene



mRNA Expression by UniProt/SwissProt for NME1 Gene

P15531-NDKA_HUMAN
Tissue specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed.
genes like me logo Genes that share expression patterns with NME1: view

Protein tissue co-expression partners for NME1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NME1 Gene

Orthologs for NME1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NME1 35
  • 89.04 (n)
  • 93.42 (a)
NME1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NME1 35
  • 88.6 (n)
  • 92.76 (a)
-- 36
  • 82 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
NME1 36
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nme1 35
  • 87.72 (n)
  • 94.08 (a)
Nme1 16
Nme1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NME1 35
  • 99.56 (n)
  • 99.34 (a)
NME1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nme1 35
  • 88.16 (n)
  • 95.39 (a)
oppossum
(Monodelphis domestica)
Mammalia NME1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NME1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves NME1 35
  • 75.68 (n)
  • 84.46 (a)
NME1 36
  • 83 (a)
ManyToMany
NME2 36
  • 87 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nme2b.1 35
  • 77.48 (n)
  • 84.77 (a)
CABZ01038708.1 36
  • 61 (a)
ManyToMany
nme2a 36
  • 71 (a)
ManyToMany
nme2b.2 36
  • 78 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.221 35
fruit fly
(Drosophila melanogaster)
Insecta awd 37
  • 77 (a)
awd 36
  • 69 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F25H2.5 37
  • 66 (a)
ndk-1 36
  • 66 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 36
  • 59 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G23895 35
  • 63.56 (n)
  • 64 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4469 35
rice
(Oryza sativa)
Liliopsida Os05g0595400 35
  • 60.89 (n)
  • 62.67 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8138 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToMany
Species with no ortholog for NME1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NME1 Gene

ENSEMBL:
Gene Tree for NME1 (if available)
TreeFam:
Gene Tree for NME1 (if available)

Paralogs for NME1 Gene

Paralogs for NME1 Gene

(7) SIMAP similar genes for NME1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for NME1 Gene

genes like me logo Genes that share paralogs with NME1: view

Variants for NME1 Gene

Sequence variations from dbSNP and Humsavar for NME1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_004625 -

Variation tolerance for NME1 Gene

Residual Variation Intolerance Score: 74.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME1 Gene

HapMap Linkage Disequilibrium report
NME1
Human Gene Mutation Database (HGMD)
NME1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NME1 Gene

Disorders for NME1 Gene

MalaCards: The human disease database

(37) MalaCards diseases for NME1 Gene - From: OMIM, GeneTests, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
anal canal carcinoma
  • carcinoma of anal canal
laryngeal carcinoma
  • cancer of larynx
hypopharynx cancer
  • malignant neoplasm of hypopharynx, nos
neuroblastoma
  • neuroblastoma 1
lung giant cell carcinoma
  • giant cell carcinoma
- elite association
Search NME1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NME1

Genetic Association Database (GAD)
NME1
Human Genome Epidemiology (HuGE) Navigator
NME1
Tumor Gene Database (TGDB):
NME1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NME1
genes like me logo Genes that share disorders with NME1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NME1 Gene

Publications for NME1 Gene

  1. NME1 at the human maternal-fetal interface downregulates titin expression and invasiveness of trophoblast cells via MAPK pathway in early pregnancy. (PMID: 20145075) Xie K.M. … Li D.J. (Reproduction 2010) 23 67
  2. Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells. (PMID: 19195866) Liu H.K. … Chen B.Q. (J. Nutr. Biochem. 2010) 23 67
  3. The Nm23-H1 metastasis suppressor as a translational target. (PMID: 20304626) Marshall J.C. … Steeg P. (Eur. J. Cancer 2010) 23 67
  4. YNK1, the yeast homolog of human metastasis suppressor NM23, is required for repair of UV radiation- and etoposide-induced DNA damage. (PMID: 18983998) Yang M. … Kaetzel D.M. (Mutat. Res. 2009) 23 67
  5. Inhibitory effect of anti-hepatitis drug bicyclol on invasion of human hepatocellular carcinoma MHCC97-H cells with high metastasis potential and its relative mechanisms. (PMID: 20183293) Sun H. … Liu G.T. (J Asian Nat Prod Res 2009) 23 67

Products for NME1 Gene

Sources for NME1 Gene

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