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Aliases for NME1 Gene

Aliases for NME1 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 1 2 3
  • NM23 3 4 6
  • Non-Metastatic Cells 1, Protein (NM23A) Expressed In 2 3
  • Tumor Metastatic Process-Associated Protein 3 4
  • Metastasis Inhibition Factor Nm23 3 4
  • Granzyme A-Activated DNase 3 4
  • NDP Kinase A 3 4
  • EC 2.7.4.6 4 63
  • NM23-H1 3 4
  • NDPKA 3 4
  • GAAD 3 4
  • Nucleoside Diphosphate Kinase A 3
  • NDPK-A 3
  • NDK A 4
  • NDKA 3
  • AWD 3
  • NBS 3
  • NB 3

External Ids for NME1 Gene

Previous GeneCards Identifiers for NME1 Gene

  • GC17P048944
  • GC17P051712
  • GC17P049572
  • GC17P049705
  • GC17P046585
  • GC17P049231
  • GC17P044601

Summaries for NME1 Gene

Entrez Gene Summary for NME1 Gene

  • This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]

GeneCards Summary for NME1 Gene

NME1 (NME/NM23 Nucleoside Diphosphate Kinase 1) is a Protein Coding gene. Diseases associated with NME1 include neuroblastoma and acute monocytic leukemia. Among its related pathways are Integrated Pancreatic Cancer Pathway and Regulation of CDC42 activity. GO annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is NME7.

UniProtKB/Swiss-Prot for NME1 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3-5 exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3 end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

Gene Wiki entry for NME1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME1 Gene

Genomics for NME1 Gene

Regulatory Elements for NME1 Gene

Genomic Location for NME1 Gene

Start:
51,153,536 bp from pter
End:
51,162,428 bp from pter
Size:
8,893 bases
Orientation:
Plus strand

Genomic View for NME1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NME1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME1 Gene

Proteins for NME1 Gene

  • Protein details for NME1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15531-NDKA_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase A
    Protein Accession:
    P15531
    Secondary Accessions:
    • Q6FGK3
    • Q86XQ2
    • Q9UDJ6

    Protein attributes for NME1 Gene

    Size:
    152 amino acids
    Molecular mass:
    17149 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with PRUNE. Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Within this complex, interacts directly with SET. Also interacts with TREX1, but only following translocation to the nucleus.
    Miscellaneous:
    • The role of this protein in tumor development and progression is uncertain. This protein is found in reduced amount in some tumor cells of high metastatic potential. However, increased NME1 levels correlate with aggressive tumor features in neuroblastoma. May have distinct if not opposite roles in different tumors
    SequenceCaution:
    • Sequence=CAA35621.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NME1 Gene

    Alternative splice isoforms for NME1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NME1 Gene

Proteomics data for NME1 Gene at MOPED

Post-translational modifications for NME1 Gene

  • Ubiquitination at Lys12, Lys26, Lys49, Lys56, and Lys100
  • Modification sites at PhosphoSitePlus

Other Protein References for NME1 Gene

Domains for NME1 Gene

Protein Domains for NME1 Gene

Suggested Antigen Peptide Sequences for NME1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15531

UniProtKB/Swiss-Prot:

NDKA_HUMAN :
  • P15531
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME1: view

No data available for Gene Families for NME1 Gene

Function for NME1 Gene

Molecular function for NME1 Gene

GENATLAS Biochemistry: non-metastatic cells 1,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of nucleoside diphosphates,with a reduced expression in tumor progression to the metastatic phenotype,mutated in agressive neuroblastoma,expressed in lung carcinoma cell lines not in normal lung,pyrimidine biosynthetic pathway
UniProtKB/Swiss-Prot CatalyticActivity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Autophosphorylation at His-118 increases serine/threonine protein kinase activity of the enzyme. Interaction with the SET complex inhibits the endonuclease activity.
UniProtKB/Swiss-Prot Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3-5 exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3 end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

Enzyme Numbers (IUBMB) for NME1 Gene

Gene Ontology (GO) - Molecular Function for NME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 11555662
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0003697 single-stranded DNA binding IEA --
GO:0004536 deoxyribonuclease activity IDA 11555662
GO:0004550 nucleoside diphosphate kinase activity IDA 12972261
genes like me logo Genes that share ontologies with NME1: view
genes like me logo Genes that share phenotypes with NME1: view

Animal Models for NME1 Gene

MGI Knock Outs for NME1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for NME1 Gene

Localization for NME1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NME1 Gene

Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NME1 Gene COMPARTMENTS Subcellular localization image for NME1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 16130169
GO:0005737 cytoplasm TAS 16130169
GO:0005739 mitochondrion IBA --
GO:0005813 centrosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NME1: view

Pathways for NME1 Gene

genes like me logo Genes that share pathways with NME1: view

Gene Ontology (GO) - Biological Process for NME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002762 negative regulation of myeloid leukocyte differentiation IEA --
GO:0006163 purine nucleotide metabolic process IBA --
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006220 pyrimidine nucleotide metabolic process IBA --
genes like me logo Genes that share ontologies with NME1: view

Compounds for NME1 Gene

(21) HMDB Compounds for NME1 Gene

Compound Synonyms Cas Number PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxyinosine-5'-triphosphate
16595-02-1
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
CDP
  • CDP
63-38-7
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)
65-47-4

(52) Novoseek inferred chemical compound relationships for NME1 Gene

Compound -log(P) Hits PubMed IDs
phosphohistidine 51.3 1
histidine 38.8 17
paraffin 36.8 9
diphosphates 36 2
vegf 36 57
genes like me logo Genes that share compounds with NME1: view

Transcripts for NME1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NME1 Gene

No ASD Table

Relevant External Links for NME1 Gene

GeneLoc Exon Structure for
NME1
ECgene alternative splicing isoforms for
NME1

Expression for NME1 Gene

mRNA expression in normal human tissues for NME1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NME1 Gene

mRNA Expression by UniProt/SwissProt for NME1 Gene

P15531-NDKA_HUMAN
Tissue specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed.
genes like me logo Genes that share expressions with NME1: view

No data available for mRNA differential expression in normal tissues for NME1 Gene

Orthologs for NME1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NME1 35
  • 99.56 (n)
  • 99.34 (a)
NME1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NME1 35
  • 89.04 (n)
  • 93.42 (a)
NME1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
NME1 35
  • 88.6 (n)
  • 92.76 (a)
NME1 36
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nme1 35
  • 87.72 (n)
  • 94.08 (a)
Nme1 16
Nme1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NME1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NME1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nme1 35
  • 88.16 (n)
  • 95.39 (a)
chicken
(Gallus gallus)
Aves NME1 35
  • 75.68 (n)
  • 84.46 (a)
NME1 36
  • 83 (a)
ManyToMany
NME2 36
  • 87 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.221 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01038708.1 36
  • 61 (a)
ManyToMany
nme2a 36
  • 71 (a)
ManyToMany
nme2b.1 35
  • 77.48 (n)
  • 84.77 (a)
nme2b.2 36
  • 78 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta awd 36
  • 69 (a)
OneToMany
awd 37
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea ndk-1 36
  • 66 (a)
OneToMany
F25H2.5 37
  • 66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 36
  • 59 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G23895 35
  • 63.56 (n)
  • 64 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4469 35
rice
(Oryza sativa)
Liliopsida Os05g0595400 35
  • 60.89 (n)
  • 62.67 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8138 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToMany
Species with no ortholog for NME1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NME1 Gene

ENSEMBL:
Gene Tree for NME1 (if available)
TreeFam:
Gene Tree for NME1 (if available)

Paralogs for NME1 Gene

Paralogs for NME1 Gene

Selected SIMAP similar genes for NME1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for NME1 Gene

genes like me logo Genes that share paralogs with NME1: view

Variants for NME1 Gene

Sequence variations from dbSNP and Humsavar for NME1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_004625 -

Relevant External Links for NME1 Gene

HapMap Linkage Disequilibrium report
NME1
Human Gene Mutation Database (HGMD)
NME1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NME1 Gene

Disorders for NME1 Gene

(1) OMIM Diseases for NME1 Gene (156490)

(95) Novoseek inferred disease relationships for NME1 Gene

Disease -log(P) Hits PubMed IDs
metastasis 84.6 350
tumors 70.7 287
breast carcinoma 69.7 77
carcinoma 60.7 113
melanoma 60.6 122

Relevant External Links for NME1

Genetic Association Database (GAD)
NME1
Human Genome Epidemiology (HuGE) Navigator
NME1
Tumor Gene Database (TGDB):
NME1
genes like me logo Genes that share disorders with NME1: view

No data available for UniProtKB/Swiss-Prot for NME1 Gene

Publications for NME1 Gene

  1. Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. (PMID: 8270257) Dooley S. … Welter C. (Hum. Genet. 1994) 2 3 4 23
  2. Mutation in the nm23 gene is associated with metastasis in colorectal cancer. (PMID: 7916650) Wang L. … Banerjee S. (Cancer Res. 1993) 3 4 23
  3. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. (PMID: 10512675) Manda R. … Yokota J. (Genomics 1999) 3 4 23
  4. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL- mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. (PMID: 12628186) Fan Z. … Lieberman J. (Cell 2003) 3 4 23
  5. High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification. (PMID: 2056128) Hailat N. … Hanash S.J. (J. Clin. Invest. 1991) 3 4 23

Products for NME1 Gene

  • Addgene plasmids for NME1

Sources for NME1 Gene

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