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NME1 Gene

protein-coding   GIFtS: 71

GC17P046585
non-metastatic cells 1, protein (NM23A) expressed in
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for NME1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
AWD 2
EC 2.7.4.6 3
GAAD 2, 3
NB 2
NBS 2
NDPK-A 2
NDPKA 2, 3
NM23 1, 2, 3, 5
NM23-H1 1, 2
OTTHUMP00000174772 2
nm23-H1 3
Descriptions
Granzyme A-activated DNase 3
Metastasis inhibition factor nm23 3
NDK A 3
NDP kinase A 2, 3
Tumor metastatic process-associated protein 3
non-metastatic cells 1, protein (NM23A) expressed in 2
External Ids
HGNC: 78491
Entrez Gene: 48302
UniProtKB: P155313
Ensembl: ENSG000000110527
Search outside databases for aliases for NME1 gene

Previous GC identifers: GC17P048944 GC17P051712 GC17P049572 GC17P049705

Summaries
for NME1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for NME1:
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic
cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded
by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been
identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have
been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2)
generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of
sequence sharing identity with each individual gene product. [provided by RefSeq]

UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses
nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl
pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell
proliferation, differentiation and development, signal transduction, G protein-coupled receptor
endocytosis, and gene expression. Required for neural development including neural patterning and
cell fate determination. Has tumor metastasis-suppressive capacity

Gene Wiki entry for NME1

Genomic Location
for NME1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NME1 gene  

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

NME1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P046585:     (about GC identifiers)

Start:
 46,585,919 bp from pter
End:
 46,604,104 bp from pter
Size:
 18,186 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000017.9  NT_010783.14  

Proteins
for NME1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531 (See protein sequence)
Recommended Name: Nucleoside diphosphate kinase A  
Size: 152 amino acids; 17149 Da
Cofactor: Magnesium
Subunit: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts
with SET and PRUNE
Subcellular location: Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can
be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by
GzmA
PDB structures from and Proteopedia :
1JXV (3D)    1UCN (3D)    2HVD (3D)    2HVE (3D)    
Secondary accessions: Q6FGK3 Q86XQ2
Alternative splicing: 3 isoforms:  P15531-1   P15531-2   P22392-2   

Post-translational modifications:

  • The N-terminus is blocked1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_000260.1  NP_937818.1  


    ENSEMBL proteins: 
    ENSP00000376895 ENSP00000376894 ENSP00000312446 ENSP00000337060 ENSP00000013034 ENSP00000365572 
    ENSP00000376892 ENSP00000376888 ENSP00000376890 ENSP00000376889 ENSP00000376887 ENSP00000376886 
    ENSP00000376880 ENSP00000376882 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich CompoZr ZFN for NME1  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (NM23A)
    Human Recombinant Proteins from Abnova (NME1)
                  OriGene Purified Recombinant Human Protein: NME1 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus TAS16130169
    GO:0005737 cytoplasm TAS16130169
    About this table

    Antibodies for NME1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for NME1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for NME1  (NM23-H1/H2)
    Antibodies from Abcam (NM23A), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (NME1)
    Novus Biologicals Antibodies for NME1

    Assays for NME1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for NME1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR001564 Nuc_diP_kinase_core


       GeneDecks  NME1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P15531

    ProtoNet protein and cluster: P15531

    1 Blocks protein family: IPB001564 Nucleoside diphosphate kinase

    UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531
    Similarity: Belongs to the NDK family

    Gene Function
    for NME1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (NME1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (NME1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000269

                  Applied Biosystems Silencer® siRNAs for NME1

                  Sigma-Aldrich siRNA and siRNA Panels for NME1  
                         Sigma-Aldrich shRNA Panels and shRNA for NME1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for NME1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000269
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000269
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_000269 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_198175

    UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531
    Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses
    nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl
    pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell
    proliferation, differentiation and development, signal transduction, G protein-coupled receptor
    endocytosis, and gene expression. Required for neural development including neural patterning and
    cell fate determination. Has tumor metastasis-suppressive capacity
    Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
    Enzyme regulation: Autophosphorylation at His-118 increases serine/threonine protein kinase
    activity of the enzyme. Interaction with the SET complex inhibits exonuclease activity
    Enzyme Number (IUBMB): EC 2.7.4.6 

    Genatlas biochemistry entry for NME1:
    non-metastatic cells 1,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in
    the phosphorylation of nucleoside diphosphates,with a reduced expression in tumor progression to
    the metastatic phenotype,mutated in agressive neuroblastoma,expressed in lung carcinoma cell lines
    not in normal lung,pyrimidine biosynthetic pathway

    13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nme1):

    embryogenesisendocrine/exocrine glandgrowth/sizehematopoietic systemhomeostasis/metabolism
    lethality-postnatallethality-prenatal/perinatalliver/biliary systemnervous systemother
    reproductive systemskin/coat/nailstumorigenesis

    5/10 Gene Ontology (GO) molecular function terms (links to tree view) (see all 10 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0000287 magnesium ion binding IDA11555662
    GO:0003677 DNA binding IC11555662
    GO:0004536 deoxyribonuclease activity IDA11555662
    GO:0004550 nucleoside diphosphate kinase activity IDA12972261
    About this table

    Pathways & Interactions
    for NME1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5/8 Invitrogen iPath™ Online BioAtlas - Pathways for NME1 (see all 8 ) (Maps provided by GeneGo):
     TTP metabolism
     dCTP/dUTP metabolism
     dGTP/GTP/XTP metabolism
     dATP/dITP metabolism
     ATP/ITP metabolism

       GeneDecks  NME1 for the pathways selected above  
    About GeneDecksing

    1 Millipore Pathway for NME1
     ATP/ITP metabolism

       GeneDecks  NME1 for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  NME1  (Your Favorite Gene powered by Ingenuity) 
     Pyrimidine Metabolism
     Purine Metabolism

       GeneDecks  NME1 for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for NME1):
     hsa00230 Purine metabolism
     hsa00240 Pyrimidine metabolism

       GeneDecks  NME1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  NME1 


    5/70 Interacting proteins for NME1 (ENSP000003655723 P155311, 2) via UniProtKB, MINT, and/or STRING (see all 70 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRUNEQ86TP11STRING (score=.993) EBI-741141, EBI-2127112
    TERF1P542742STRING (score=.872) MINT-17759
    MCF2P109111EBI-741141, EBI-1914514
    NME1P155311EBI-741141, EBI-741141
    NME2P223921EBI-741141, EBI-713693
    About this table

    5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006183 GTP biosynthetic process IEA--
    GO:0006228 UTP biosynthetic process IEA--
    GO:0006241 CTP biosynthetic process IEA--
    GO:0008285 negative regulation of cell proliferation TAS1851158
    GO:0009117 nucleotide metabolic process IEA--
    About this table

    Drugs & Compounds
    for NME1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for NME1
    10/28 Novoseek chemical compound relationships for NME1 gene (see all 28 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    histidine 38.75 17 10698688 (3), 12105213 (3), 9038158 (2), 12848344 (1) (see all 11)
    slex 31.92 23 9663428 (7), 15269984 (5), 8641989 (4)
    17-(allylamino)-17-demethoxygeldanamycin 30.12 4 15684389 (1), 17022645 (1)
    crcs 28.54 2 12883690 (1)
    gtp 22.60 12 12145286 (2), 10611312 (2), 18470881 (1), 10082974 (1)
    bgl ii 22.41 2 1377015 (1), 1684428 (1)
    chi 2 14.09 3 10719723 (1), 9842967 (1), 12408341 (1)
    pyrophosphate 14.00 1 9387150 (1)
    glyceraldehyde 3-phosphate 12.35 3 9398045 (1), 10612659 (1), 7761450 (1)
    progesterone 3.97 8 16145866 (2), 11360656 (1), 8519661 (1), 17975005 (1) (see all 6)
    About this table


    Transcripts
    for NME1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (NME1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (NME1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000269

                  Sigma-Aldrich siRNA and siRNA Panels for NME1  
                         Sigma-Aldrich shRNA Panels and shRNA for NME1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000269  NM_198175  

    REFSEQ mRNAs for NME1 gene (2 alternative transcripts): 

    NM_000269.2   NM_198175.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_000269  NM_198175  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000269
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000269
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_000269 

    Additional cDNA sequence: 

    AF487339.1 AK291105.1 AK309160.1 AK313448.1 AL360166.1 AL360191.1 BC000293.2 BC002476.2 
    BC018994.2 BC095458.1 BC107894.1 BC133029.1 BC133031.1 BT007045.1 CR541718.1 CR542104.1 
    CR542115.1 CR608209.1 CR610816.1 CR620528.1 CR620825.1 CR621859.1 CR626177.1 D28367.1 
    DQ109675.1 L16785.1 M36981.1 X17620.1 X58965.1 X73066.1 

    24/52 DOTS entries (see all 52 ):

    DT.87001740  DT.100666998  DT.92467700  DT.97825132  DT.100667001  DT.95133979  DT.99954390  DT.99926493 
    DT.92467683  DT.101986310  DT.100667002  DT.91951035  DT.91888097  DT.100847325  DT.92041281  DT.99926485 
    DT.100741476  DT.97864707  DT.87017850  DT.92467701  DT.121184671  DT.92467662  DT.100667000  DT.100675075 

    24/233 AceView cDNA sequences (see all 233 ):

    CA449399 BM762008 BQ897114 AI128227 BM473942 CD105922 BF036960 BQ232688 
    BM850750 CR620528 BM051035 CB163460 BM747087 AI139946 BC018994 BG388883 
    X17620 AI242293 BU181542 AA305102 BM552890 CR626177 BG202196 BX421668 

    highest scoring ESTs for NME1:

    AL038662 X17620 AA564822 X73066 AA046312 AA046401 AA083177 AA083288 AA122205 AA130864 

    Unigene Cluster for NME1:

    Non-metastatic cells 1, protein (NM23A) expressed in
    Hs.463456  [show with all ESTs]
    Unigene Representative Sequence: BG114681


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NME1 (see all 7 )

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                    -     -                       -           -           -                     
    SP2:                    -     -     -                 -           -           -                     
    SP3:                    -     -     -                 -                       -                     
    SP4:                          -                       -           -                                 
    SP5:                    -     -     -                 -           -                                 

    About this scheme

    ECgene alternative splicing isoforms for NME1

    14 Ensembl transcripts including schematic representations:
    ENST00000393199  ENST00000393198  ENST00000311032  ENST00000336097  ENST00000013034  ENST00000376392  
    ENST00000393196  ENST00000393192  ENST00000393194  ENST00000393193  ENST00000393191  ENST00000393190  
    ENST00000393183  ENST00000393185  

    Expression
    for NME1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    NME1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for NME1

    1 / 2 / 3

    6 probe-sets matching NME1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1521_at2, 3 U95-A 1 1.00 1.00 0.87 0.94 X17620 1.00 0.87 0.94 1
    39073_at2, 3 U95-A 2 1.00 0.91 0.91 0.93 AL038662 1.00 0.87 0.94 1

    		1985_s_at2, 3 U95-A 2 1.00 0.66 0.96 1.09 X73066 0.80 1.00 0.91 1
    71854_at2, 3 U95-D 1 0.50 1.00 0.66 1.05 AA564822 0.80 1.00 0.91 1

    		201577_at2, 3 U133-A 2 1.00 0.64 -- -- NM_000269 0.60 0.78 0.69 1

    		201577_at2 U133Plus2 2 1.00 0.64 -- -- -- -- -- -- --
    GeneDecks  NME1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.463456

    Expression variation in blood from EXPOLDB for NME1

    UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531
    Tissue specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle,
    pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung
    tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor
    differentiation. Isoform 3 is ubiquitously expressed

    Orthologs
    for NME1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for NME1 gene from 5/15 species (see all 15 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 NME11   -- non-metastatic cells 1, protein (NM23A) expressed in 88.6(n)
    92.76(a)    		 480558  NM_001024637.1  NP_001019808.1 
    cow
    (Bos taurus)    		 NME11   -- non-metastatic cells 1, protein (NM23A) expressed in 89.04(n)
    94.08(a)    		 404189  NM_205818.1  NP_991387.1 
    rat
    (Rattus norvegicus)    		 Nme11   -- non-metastatic cells 1, protein (NM23A) expressed in 88.16(n)
    95.39(a)    		 191575  NM_138548.1  NP_612557.1 
    mouse
    (Mus musculus)    		 Nme11, 5 115
    		 non-metastatic cells 1, protein (NM23A) expressed in1, 5 87.72(n)1
    94.08(a)1    		 181021  NM_008704.21  NP_032730.11 
     AF0333775  AK1363535  (see all 15)
    chicken
    (Gallus gallus)    		 NME11   -- non-metastatic cells 1, protein (NM23A) expressed in 75.68(n)
    84.46(a)    		 422094  XM_420097.2  XP_420097.1 
    About this table        Species with no ortholog for NME1

    ENSEMBL Gene Tree for NME1

    Paralogs
    for NME1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for NME1 gene
    NME2P12  NME32  NME72  NME42  

    Pseudogenes
    1 related pseudogene


    SNPs/Variants
    for NME1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		  --

    Disorders & Mutations
    for NME1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 156490   disorders: 256700  

    UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531

  • This protein is found in reduced amount in tumor cells of high metastatic potential.
    Somatic mutations of NME1 are found in neuroblastoma. Increased NME1 in neuroblastoma is
    correlated with features of the disease that are associated with aggressive tumors. May therefore
    have distinct if not opposite roles in different tumors

    • 10/95 Novoseek disease relationships for NME1 gene (see all 95 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 84.57 914 11289754 (7), 8418304 (6), 11179491 (6), 16739379 (6) (see all 99)
    tumors 70.97 714 7745027 (6), 10424391 (6), 9874452 (5), 15568401 (5) (see all 99)
    breast carcinoma 70.16 90 9070493 (5), 11280805 (3), 11866905 (3), 7990158 (3) (see all 58)
    melanoma 61.62 161 8912348 (6), 9167178 (5), 17696918 (5), 7829217 (5) (see all 63)
    carcinoma 60.87 139 18996649 (5), 10523705 (3), 9570214 (3), 10914829 (3) (see all 77)
    primary tumor 59.97 54 11268486 (4), 9143023 (3), 9949298 (3), 9194030 (3) (see all 29)
    colorectal carcinoma 59.91 66 11289754 (9), 16078572 (5), 8199988 (4), 7774480 (4) (see all 27)
    large cell lung cancer 58.70 4 17167724 (1), 18440302 (1), 15757527 (1)
    ductal breast carcinoma 57.74 4 8386774 (1), 17642161 (1), 9042324 (1), 8912348 (1)
    cancer 56.38 139 8931974 (4), 10794547 (3), 10403689 (3), 16425351 (3) (see all 93)
    About this table

    Human Gene Mutation Database: NME1
    Genetic Association Database: NME1
    Human Genome Epidemiology Navigator: NME1 (4 documents)
    Tumor Gene Database: NME1
    Breast Cancer Gene Database: NME1

    Medical News
    for NME1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for NME1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/747 PubMed articles for NME1 gene (see all 747 ):

    Search for NME1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NME1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 4830 HGNC: 7849 AceView: NME1andNME2 Ensembl:ENSG00000011052 euGenes: HUgn4830
    ECgene: NME1 H-InvDB: NME1

    Other Databases showing NME1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing NME1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for NME1 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for NME1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for NME1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for NME1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for NME1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for NME1 Antibodies for NME1
     Explore super-pooled esiRNAs Proteins for NME1
     Lentivirus-delivered shRNAs for NME1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Antibodies & Assays for NME1  (NM23-H1/H2)

     Recombinant Proteins
    (NM23A)
     Antibodies (NM23A)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for NME1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for NME1

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