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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NME1 Gene

protein-coding GIFtS: 65
GCID: GC17P049231

NME/NM23 nucleoside diphosphate kinase 1

(Previous names: non-metastatic cells 1, protein (NM23A) expressed in )

Explore 121 diseases affiliated with
NME1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NME/NM23 Nucleoside Diphosphate Kinase 1¹ ²		EC 2.7.4.6³ ⁸
NM23¹ ² ³ ⁵		AWD²
NM23-H1¹ ²		NB²
Non-Metastatic Cells 1, Protein (NM23A) Expressed In¹ ²		NBS²
Granzyme A-Activated DNase² ³		NDKA²
Metastasis Inhibition Factor Nm23² ³		NDPK-A²
Tumor Metastatic Process-Associated Protein² ³		Nucleoside Diphosphate Kinase A²
GAAD² ³		NDK A³
NDPKA² ³		Nm23-H1¹
NDP Kinase A² ³

External Ids:	HGNC: 7849¹	Entrez Gene: 4830²	Ensembl: ENSG00000239672⁷	OMIM: 156490⁵	UniProtKB: P15531³

Export aliases for NME1 gene to outside databases

Previous GC identifers: GC17P048944 GC17P051712 GC17P049572 GC17P049705 GC17P046585 GC17P044601

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NME1:

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside

diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2)

isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding

different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene

(NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence

sharing identity with each individual gene product. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531

Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate

kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase

and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal

transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including

neural patterning and cell fate determination

Gene Wiki entry for NME1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NME1 gene promoter:
c-Fos AP-1 ATF-2 c-Jun
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for NME1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NME1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21.33

NME1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NME1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P049231: view genomic region (about GC identifiers)

Start:	49,230,897 bp from pter	End:	49,239,789 bp from pter
Size:	8,893 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531 (See protein sequence)

Recommended Name: Nucleoside diphosphate kinase A

Size: 152 amino acids; 17149 Da

Cofactor: Magnesium

Subunit: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with SET and PRUNE

Subcellular location: Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by

interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA

Miscellaneous: The role of this protein in tumor development and progression is uncertain. This protein is found in

reduced amount in some tumor cells of high metastatic potential. However, increased NME1 levels correlate with

aggressive tumor features in neuroblastoma. May have distinct if not opposite roles in different tumors

Sequence caution: Sequence=CAA35621.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

5 PDB 3D structures from and Proteopedia for NME1:

1JXV (3D)

1UCN (3D)

2HVD (3D)

2HVE (3D)

3L7U (3D)

Secondary accessions: Q6FGK3 Q86XQ2 Q9UDJ6

Alternative splicing: 3 isoforms: P15531-1 P15531-2 P22392-2 (Based on a naturally occurring readthrough transcript which produces an NME1-NME2 fusion protein)

Explore the universe of human proteins at neXtProt for NME1: NX_P15531

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P15531

4/10 DME Specific Peptides for NME1 (P15531) (see all 10)

PGTIRGD

RFEQKGF

NIIHGSD

ASEDLLK

NME1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000260.1 NP_937818.1

ENSEMBL proteins:

ENSP00000376892 ENSP00000337060 ENSP00000429318 ENSP00000428553 ENSP00000435498

ENSP00000013034 ENSP00000387682

Reactome Protein details: P15531
Human Recombinant Protein Products for NME1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): NME1 OriGene Protein Over-expression Lysate (see all 2): NME1 OriGene Custom Protein Services for NME1
	GenScript Custom Purified and Recombinant Proteins Services for NME1
	Novus Biologicals NME1 Proteins Novus Biologicals NME1 Lysates
	Sino Biological Recombinant Protein for NME1
	ProSpec Recombinant Protein for NME1
	Uscn Proteins for NME1

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	TAS	16130169
GO:0005737	cytoplasm	TAS	16130169
GO:0005739	mitochondrion	--	--
GO:0005792	microsome	--	--

NME1 for ontologies About GeneDecksing

NME1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NME1
	R&D Systems Antibodies for NME1 (NM23-H1/H2, NM23-H1)
	Cell Signaling Technology (CST) Antibodies for NME1 (NM23)
	OriGene Antibodies (see all 30): NME1 OriGene Custom Antibody Services for NME1
	GenScript Custom Superior Antibodies Services for NME1
	Novus Biologicals NME1 Antibodies
	Abcam antibodies for NME1
	Uscn Antibodies for NME1
	ThermoFisher Antibody for NME1

Assay Products for NME1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NME1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NME1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NME1 for domains About GeneDecksing

2 InterPro domains/families:

IPR023005 Nucleoside_diP_kinase_AS

IPR001564 Nucleoside_diP_kinase

Graphical View of Domain Structure for InterPro Entry P15531

ProtoNet protein and cluster: P15531

1 Blocks protein family: IPB001564 Nucleoside diphosphate kinase

UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531

Similarity: Belongs to the NDK family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NDKA_HUMAN, P15531

Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate

kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase

and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal

transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including

neural patterning and cell fate determination

Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

Enzyme regulation: Autophosphorylation at His-118 increases serine/threonine protein kinase activity of the enzyme.

Interaction with the SET complex inhibits exonuclease activity

Genatlas biochemistry entry for NME1:

non-metastatic cells 1,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of

nucleoside diphosphates,with a reduced expression in tumor progression to the metastatic phenotype,mutated in

agressive neuroblastoma,expressed in lung carcinoma cell lines not in normal lung,pyrimidine biosynthetic pathway

Enzyme Number (IUBMB): EC 2.7.4.6¹ ²

Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IDA	11555662
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IEA	--
GO:0003697	single-stranded DNA binding	IEA	--
GO:0004536	deoxyribonuclease activity	IDA	11555662
GO:0004550	nucleoside diphosphate kinase activity	IDA	12972261

NME1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for NME1:

Decreased melanin production

Increased mitotic index

11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nme1):

embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
integument	liver/biliary system	mortality/aging	nervous system	other
tumorigenesis

NME1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Nme1/Nme2^Nme1/tm1Zou for NME1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NME1

miRNA Products:		OriGene 3'-UTR Clone (see all 2): NME1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NME1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate NME1:
		hsa-miR-141 hsa-miR-200a
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NME1 (see all 7) OriGene shRNA RFP: NME1 OriGene siRNA: NME1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NME1
		Sirion Biotech Custom design and validation of potent shRNA sequences against NME1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NME1
			Sirion Biotech Customized adenovirus for overexpression of NME1 Sirion Biotech Customized adenovirus for potent knockdown of NME1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NME1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NME1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): NME1 (NM_000269)
		Sino Biological Human cDNA Clone for NME1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NME1
		Search LifeMap BioReagents cell lines for NME1
		Sirion Biotech Customized stable knockdown cell line services for NME1 Sirion Biotech Customized inducible knockdown cell line services for NME1 Sirion Biotech Customized stable overexpressing cell line services for NME1 Sirion Biotech Customized inducible overexpressing cell line services for NME1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NME1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

pyrimidine ribonucleotides interconversion

	pyrimidine ribonucleotides interconversion	1.00			pyrimidine deoxyribonucleotides de novo biosynthesis I	0.50
	pyrimidine ribonucleotides de novo biosynthesis	0.88			salvage pathways of pyrimidine ribonucleotides	0.45

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

ATP/ITP metabolism

ATP/ITP metabolism

1.00

ATP/ITP metabolism

0.98

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

Purine metabolism

Purine metabolism

1.00

Pyrimidine metabolism

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NME1

ATP/ITP metabolism

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NME1

	Granzyme-A Pathway
	Remodeling of Adherens Junctions
	Granzyme Pathway

1 Cell Signaling Technology (CST) Pathway for NME1

Translational Control

1 GeneGo (Thomson Reuters) Pathway for NME1

ATP/ITP metabolism

5/12 BioSystems Pathways for NME1 (see all 12)

	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Validated targets of C-MYC transcriptional activation
	Arf6 trafficking events
	pyrimidine ribonucleotides interconversion

3 Reactome Pathways for NME1

	Metabolism of nucleotides
	Synthesis and interconversion of nucleotide di- and triphosphates
	Metabolism

3 PharmGKB Pathways for NME1

	Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
	Tenofovir/Adefovir Pathway, Pharmacokinetics
	Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

3 Kegg Pathways (Kegg details for NME1):

	Purine metabolism
	Pyrimidine metabolism
	Metabolic pathways

NME1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NME1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/149 Interacting proteins for NME1 (P15531^{1, 2, 3} ENSP00000013034⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 149)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NME2	P22392¹^,³, ENSP00000365572⁴	EBI-741141,EBI-713693 I2D: score=2 STRING: ENSP00000365572
TERF1	P54274²^,³, ENSP00000276603⁴	MINT-17759 I2D: score=4 STRING: ENSP00000276603
NME1-NME2	P22392¹^,³	EBI-741141,EBI-713693 I2D: score=2
STRAP	Q9Y3F4¹^,³, ENSP00000392270⁴	EBI-741141,EBI-727414 I2D: score=2 STRING: ENSP00000392270
NME1	P15531¹^,²	EBI-741141,EBI-741141 MINT-68463

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002762	negative regulation of myeloid leukocyte differentiation	IEA	--
GO:0006165	nucleoside diphosphate phosphorylation	--	--
GO:0006183	GTP biosynthetic process	IEA	--
GO:0006228	UTP biosynthetic process	IEA	--
GO:0006241	CTP biosynthetic process	IEA	--

NME1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NME1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NME1

10/21 HMDB Compounds for NME1 (see all 21) About this table

Compound	Synonyms	CAS #	PubMed Ids
2'-Deoxyinosine triphosphate	2'-Deoxyinosine-5'-triphosphate (see all 6)	16595-02-1	--
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
CDP	CDP (see all 3)	63-38-7	--
Cytidine triphosphate	cytidine 5'-(tetrahydrogen triphosphate) (see all 15)	65-47-4	--
Deoxyuridine triphosphate	2'-Deoxyuridine-5'-triphosphorate (see all 9)	1173-82-6	--
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
IDP	5'-IDP (see all 10)	86-04-4	--
Inosine triphosphate	inosine 5'-(tetrahydrogen triphosphate) (see all 13)	132-06-9	--

10/13 DrugBank Compounds for NME1 (see all 13) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate	--	--	target	--	17139284 17016423 10592235
2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate	--	--	target	--	17139284 17016423 10592235
2'-Deoxyguanosine-5'-Diphosphate	--	--	target	--	17139284 17016423 10592235
2'-Deoxyguanosine-5'-Triphosphate	--	2564-35-4	target	--	17139284 17016423 10592235
3'-Azido-3'-Deoxythymidine-5'-Diphosphate	--	--	target	--	17139284 17016423 10592235
3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate	--	--	target	--	17139284 17016423 10592235
Adenosine Phosphonoacetic Acid	--	--	target	--	17139284 17016423 10592235
Fudp	--	--	target	--	17139284 17016423 10592235
Guanosine-5'-Diphosphate	--	146-91-8	target	--	17139284 17016423 10592235
Pyrophosphate 2-	--	--	target	--	17139284 17016423 10592235

10/52 Novoseek chemical compound relationships for NME1 gene (see all 52) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphohistidine	51.3	1	19415463 (1)
histidine	38.8	19	10698688 (3), 12105213 (3), 9038158 (2), 12848344 (1) (see all 12)
paraffin	36.8	9	8386774 (1), 15190803 (1), 9888669 (1), 11855920 (1) (see all 9)
diphosphates	36	2	11343655 (1), 8245015 (1)
vegf	36	70	15604068 (7), 12761948 (6), 12768677 (5), 17283532 (5) (see all 22)
slex	30.6	23	9663428 (7), 15269984 (5), 8641989 (4)
17-(allylamino)-17-demethoxygeldanamycin	27.9	4	15684389 (1), 17022645 (1)
crcs	25.4	2	12883690 (1)
bgl ii	21.5	2	1377015 (1), 1684428 (1)
gtp	21.4	12	12145286 (2), 10611312 (2), 18470881 (1), 10082974 (1)

Search CenterWatch for drugs/clinical trials and news about NME1 / NDKA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NME1 gene (2 alternative transcripts):

NM_000269.2 NM_198175.1

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000393196(uc002iti.2) ENST00000487481 ENST00000336097(uc002ith.2)

ENST00000480143 ENST00000512768(uc010dbx.2) ENST00000511355 ENST00000475573

ENST00000013034 ENST00000456492 ENST00000465188

miRNA Products:		OriGene 3'-UTR Clone (see all 2): NME1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NME1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate NME1:
		hsa-miR-141 hsa-miR-200a
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NME1 (see all 7) OriGene shRNA RFP: NME1 OriGene siRNA: NME1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NME1
		Sirion Biotech Custom design and validation of potent shRNA sequences against NME1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NME1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NME1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): NME1 (NM_000269)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NME1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NME1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NME1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NME1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NME1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NME1

24/233 AceView cDNA sequences (see all 233):

BQ638654 BE386050 BM553122 CB108710 BG164928 BU186842 BQ217266 BE784067

BQ223345 CB119276 BU182293 CD105922 BM771457 BE396723 CB163460 BI753048

AI139946 CR542104 BG202196 AA378469 BM855033 BM423971 CA449399 BP870703

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NME1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See NME1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NME1

UniProtKB/Swiss-Prot: NDKA_HUMAN, P15531

Tissue specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen

and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed

and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed

SABiosciences Expression via Pathway-Focused PCR Arrays including NME1:

Adherens Junctions in human mouse rat

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Tumor Metastasis in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for NME1 gene from 8/35 species (see all 35) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NME1¹	non-metastatic cells 1, protein (NM23A) expressed in	75.68(n) 84.46(a)		422094 NM_001204761.1 NP_001191690.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 5)	--	49(a) 29(a) (see all 5)	1 ↔ many possible ortholog (see all 5)	2(117754712-117771891) 6(47767459-47772252)
zebrafish (Danio rerio)	Actinopterygii	nme2a¹	non-metastatic cells 2a, protein (NM23B) expressed more	71.62(n) 80.41(a)		335716 NM_199970.1 NP_956264.1
fruit fly (Drosophila melanogaster)	Insecta	awd³	CTP biosynthesis nucleoside-diphosphate kinase	77(a)		100D2 --
worm (Caenorhabditis elegans)	Secernentea	F25H2.5³	nucleoside diphosphate kinase	66(a)		I(10561041-10562106) --
thale cress (Arabidopsis thaliana)	eudicotyledons	NDPK1¹	nucleoside diphosphate kinase 1	62.55(n) 61.04(a)		826515 NM_117000.2 NP_567346.1
rice (Oryza sativa)	Liliopsida	Os10g0563700¹	hypothetical protein	63.27(n) 60.54(a)		4349403 NM_001071936.1 NP_001065404.1
E. coli (Escherichia coli)	Gamma proteobacteria	ndk⁶	multifunctional nucleoside diphosphate kinase and ...	42(a)	possible ortholog	Chromosome(2642455-2642886)

ENSEMBL Gene Tree for NME1 (if available)
TreeFam Gene Tree for NME1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NME1 gene

NME2² NME3² NME8² NME4² NME7² NME1-NME2² NME6² NME9²

NME5²

8 SIMAP similar genes for NME1 using alignment to 4 protein entries: NDKA_HUMAN (see all proteins):

NME1-NME2 NME2 NME3 NME2P1 c371H6.2 NME4

NME7 NME6

NME1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for NME1
PGOHUM00000248324 PGOHUM00000248523

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121917887^1,2	C	untested	49239105(+)	`ATGGCA/GGTGAT`	6	S G	int¹ mis¹		0	--	--	--	--
rs146625530^1,2		--	49228975(+)	`TAAAGA/GCCGAG`	4	--	us2k¹		0	--	--	--	--
rs191753893^1,2		--	49228984(+)	`AGCACG/TGTGGC`	4	--	us2k¹		0	--	--	--	--
rs2318783^1,2		--	49229153(+)	`tttggA/Gaggct`	4	--	us2k¹		0	--	--	--	--
rs7502450^1,2	C	--	49229286(+)	`ctcggA/Gaggct`	4	--	us2k¹		0	--	--	--	--
rs113719724^1,2	C	--	49229321(+)	`TGGAGG/TCAGAG`	4	--	us2k¹		3		WA NA	6
rs28880579^1,2	C	--	49229410(+)	`AAAAAA/GAAAAA`	4	--	us2k¹		1		WA	2
rs187447341^1,2		--	49229436(+)	`GGTGGC/GAGACG`	4	--	us2k¹		0	--	--	--	--
rs192933096^1,2		--	49229481(+)	`GAGAAA/TCGCTT`	4	--	us2k¹		0	--	--	--	--
rs185525408^1,2		--	49229651(+)	`AGTCTA/CGCTCT`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NME1 (49230897 - 49239789 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NME1: --
Human Gene Mutation Database (HGMD): NME1

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NME1 for disorders           About GeneDecksing

OMIM gene information: 156490
OMIM disorders: 256700
20/121 diseases for NME1 (see all 121):    About MalaCards

smooth muscle tumor neuroblastoma diffuse large b-cell lymphoma soft tissue sarcoma

cervical intraepithelial neoplasia anal canal carcinoma squamous cell carcinoma non-small cell lung carcinoma

b-cell lymphomas laryngeal squamous cell carcinoma acute monocytic leukemia carcinoma

testicular germ cell tumor monocytic leukemia non-hodgkin lymphoma multiple endocrine neoplasia

germ cell tumor gastrointestinal stromal tumor myeloid leukemia laryngitis

10/95 Novoseek disease relationships for NME1 gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	84.6	965	11289754 (7), 8418304 (6), 11179491 (6), 16739379 (6) (see all 99)
tumors	70.7	732	7745027 (6), 10424391 (6), 9874452 (5), 8199988 (5) (see all 99)
breast carcinoma	69.7	90	9070493 (5), 11280805 (3), 11866905 (3), 7990158 (3) (see all 58)
carcinoma	60.7	144	18996649 (5), 10523705 (3), 9570214 (3), 10914829 (3) (see all 78)
melanoma	60.6	161	8912348 (6), 9167178 (5), 17696918 (5), 7829217 (5) (see all 63)
ductal breast carcinoma	59.7	4	8386774 (1), 17642161 (1), 9042324 (1), 8912348 (1)
colorectal carcinoma	59.4	71	11289754 (9), 16078572 (5), 8199988 (4), 7774480 (4) (see all 27)
primary tumor	59.4	54	11268486 (4), 9143023 (3), 9949298 (3), 9194030 (3) (see all 29)
large cell lung cancer	58.2	4	17167724 (1), 18440302 (1), 15757527 (1)
cancer	57.4	147	8931974 (4), 10794547 (3), 16425351 (3), 10403689 (3) (see all 99)

Genetic Association Database (GAD): NME1
Human Genome Epidemiology (HuGE) Navigator: NME1 (7 documents)
Tumor Gene Database (TGDB): NME1

Export disorders for NME1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NME1 gene, integrated from 9 sources (see all 859):
(articles sorted by number of sources associating them with NME1)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. (PubMed id 8270257)^{1, 2, 3, 9} Dooley S.... Welter C. (1994)
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL- mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. (PubMed id 12628186)^{1, 2, 9} Fan Z.... Lieberman J. (2003)
High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification. (PubMed id 2056128)^{1, 2, 9} Hailat N.... Hanash S.J. (1991)
Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. (PubMed id 10512675)^{1, 2, 9} Manda R.... Yokota J. (1999)
Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells. (PubMed id 8810265)^{1, 2, 9} MacDonald N.J.... Steeg P.S. (1996)
Mutation in the nm23 gene is associated with metastasis in colorectal cancer. (PubMed id 7916650)^{1, 2, 9} Wang L.... Banerjee S. (1993)
Nme protein family evolutionary history, a vertebrate perspective. (PubMed id 19852809)^{1, 3} Desvignes T....Bobe J. (2009)
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)^{1, 2} Meierhofer D.... Kaiser P. (2008)
EcoRI polymorphism of the metastasis-suppressor gene NME1 in Mexican patients with breast cancer. (PubMed id 16317582)^{1, 4} Rubio S.A....Moguel M.C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4830	HGNC: 7849	AceView: NME1andNME2	Ensembl:ENSG00000239672	euGenes: HUgn4830
ECgene: NME1	Kegg: 4830	H-InvDB: NME1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NME1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NME1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NME1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NME1 gene:
Search GeneIP for patents involving NME1

GeneCards and IP:
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NME1 Gene

NME/NM23 nucleoside diphosphate kinase 1

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NME1 (Gene Symbol)
NME/NM23 Nucleoside Diphosphate Kinase 1
NM23
NM23-H1
Non-Metastatic Cells 1, Protein (NM23A) Expressed In
Granzyme A-Activated DNase
Metastasis Inhibition Factor Nm23
Tumor Metastatic Process-Associated Protein
GAAD
NDPKA
NDP Kinase A
EC 2.7.4.6
AWD
NB
NBS
NDKA
NDPK-A
Nucleoside Diphosphate Kinase A
NDK A
Nm23-H1

nonmetastatic
COMEDO
Microsatellite Instability
Retinoblastoma
Oncocytoma
THYROID FOLLICULAR CARCINOMA
aggressiveness
COLON CARCINOMA
LUNG CARCINOMA
Lymphatic Metastasis
invasive ductal breast carcinoma
Breast Cancer
NSCLC
primary tumor
Adenocarcinoma
Seminoma
Carcinoma Transitional Cell
Cancer
stage III ovarian cancer
Colorectal Carcinoma
Cervical Intraepithelial Neoplasia
ADENOCARCINOMA GASTRIC
Leukoplakia
Carcinoma Non-Small Cell Lung
GASTRIC CARCINOMA
cervical adenocarcinoma
Ovarian Cancer
GALLBLADDER CARCINOMA
Precancerous lesions
Colorectal Cancer
HNSCC
Smooth Muscle Tumor
large cell lung cancer
Hypopharyngeal Cancer
Thyroid Neoplasms
Adenocarcinoma Papillary
SKIN MELANOMA
Cervical Cancer
ENDOMETRIAL CARCINOMA
Tumors
Metastasis
Carcinoma Ductal
prostatic adenocarcinoma
breast cancer metastatic
Fibroadenoma
stage neuroblastoma
Gastric Cancer
Ovarian Neoplasms
Myeloid Leukemia
indolent lymphoma
BREAST CARCINOMA
Melanoma
adult soft tissue sarcoma
bladder cancer
Colon Cancer
ESOPHAGEAL CARCINOMA
Adenoma Follicular
Squamous Cell Cancer
NSCLC Stage I
Carcinoma
Leukemia
Myeloid Leukemia Chronic
LARYNGEAL CARCINOMA
PROSTATE CARCINOMA
Hydatidiform Mole
ductal breast carcinoma
Osteosarcoma
Allelic Loss
Carcinoma Endometrioid
metastatic cancer
Carcinoma Papillary
Laryngeal Cancer
HEPATOCELLULAR CARCINOMA
CERVICAL CARCINOMA
Carcinoma Anaplastic
metastatic melanoma
Carcinoma Renal Cell
laryngeal squamous cell carcinoma
Cancer Lung
aggressive behavior
Keratoacanthoma
Acute monocytic leukemia
NASOPHARYNGEAL CARCINOMA
Adenoma
uveal melanoma
benign tumor
OVARIAN CARCINOMA
Carcinoma Squamous Cell
Colorectal Tumors
Carcinoma Intraductal
liver metastases
Endometrial Hyperplasia
Carcinoma Adenosquamous
THYROID CARCINOMA
Lymphoma T-Cell Peripheral

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NME1 Gene

NME/NM23 nucleoside diphosphate kinase 1

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