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Aliases for NME1 Gene

Aliases for NME1 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 1 2 3 5
  • Non-Metastatic Cells 1, Protein (NM23A) Expressed In 2 3
  • Tumor Metastatic Process-Associated Protein 3 4
  • Metastasis Inhibition Factor Nm23 3 4
  • Granzyme A-Activated DNase 3 4
  • NDP Kinase A 3 4
  • EC 2.7.4.6 4 61
  • NM23-H1 3 4
  • NDPKA 3 4
  • GAAD 3 4
  • NM23 3 4
  • Nucleoside Diphosphate Kinase A 3
  • NDPK-A 3
  • NDK A 4
  • NDKA 3
  • NBS 3
  • AWD 3
  • NB 3

External Ids for NME1 Gene

Previous GeneCards Identifiers for NME1 Gene

  • GC17P048944
  • GC17P051712
  • GC17P049572
  • GC17P049705
  • GC17P046585
  • GC17P049231
  • GC17P044601

Summaries for NME1 Gene

Entrez Gene Summary for NME1 Gene

  • This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]

GeneCards Summary for NME1 Gene

NME1 (NME/NM23 Nucleoside Diphosphate Kinase 1) is a Protein Coding gene. Diseases associated with NME1 include Neuroblastoma and Anal Canal Carcinoma. Among its related pathways are Validated targets of C-MYC transcriptional activation and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. GO annotations related to this gene include poly(A) RNA binding and GTP binding. An important paralog of this gene is NME1-NME2.

UniProtKB/Swiss-Prot for NME1 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3-5 exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3 end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

Gene Wiki entry for NME1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME1 Gene

Genomics for NME1 Gene

Regulatory Elements for NME1 Gene

Enhancers for NME1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G051152 1.2 ENCODE 37.6 +0.1 143 2.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 NME1 CACNA1G-AS1 SPAG9 NME2 COL1A1 UTP18 NME1-NME2
GH17G050945 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.3 -204.3 -204284 6.8 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 NME1 WFIKKN2 NME1-NME2 NME2 ENSG00000251665 ENSG00000247011 ENSG00000249870
GH17G051131 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20 -20.7 -20681 2.2 PKNOX1 FOXA2 YBX1 THRB GATA2 ZNF207 ETV6 FOS RELB CREM NME1 SPAG9 NME1-NME2
GH17G051138 1.1 ENCODE dbSUPER 23.5 -13.6 -13639 1.9 HDAC1 HDGF ZNF207 ETV6 RELB CREM IKZF2 MIXL1 EGR2 ZNF263 NME1 UTP18 NME1-NME2 SPAG9
GH17G051257 1.2 ENCODE 16.8 +106.3 106313 5.2 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 UTP18 NME1 MBTD1 ENSG00000264895
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NME1 on UCSC Golden Path with GeneCards custom track

Promoters for NME1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095799 264 2001 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263

Genomic Location for NME1 Gene

Chromosome:
17
Start:
51,153,536 bp from pter
End:
51,162,428 bp from pter
Size:
8,893 bases
Orientation:
Plus strand

Genomic View for NME1 Gene

Genes around NME1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME1 Gene

Proteins for NME1 Gene

  • Protein details for NME1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15531-NDKA_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase A
    Protein Accession:
    P15531
    Secondary Accessions:
    • Q6FGK3
    • Q86XQ2
    • Q9UDJ6

    Protein attributes for NME1 Gene

    Size:
    152 amino acids
    Molecular mass:
    17149 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with PRUNE. Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Within this complex, interacts directly with SET. Also interacts with TREX1, but only following translocation to the nucleus.
    Miscellaneous:
    • The role of this protein in tumor development and progression is uncertain. This protein is found in reduced amount in some tumor cells of high metastatic potential. However, increased NME1 levels correlate with aggressive tumor features in neuroblastoma. May have distinct if not opposite roles in different tumors.
    SequenceCaution:
    • Sequence=CAA35621.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NME1 Gene

    Alternative splice isoforms for NME1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NME1 Gene

Selected DME Specific Peptides for NME1 Gene

P15531:
  • MLGETNPADSKPG
  • ASEDLLK
  • MVWEGLNVVKTGR
  • PVVAMVWEG
  • HGSDSVE
  • NIIHGSD
  • SGPVVAMV
  • PGTIRGD
  • RFEQKGF
  • KPDGVQR

Post-translational modifications for NME1 Gene

  • Ubiquitination at Lys100
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NME1 (NME1)

Domains & Families for NME1 Gene

Gene Families for NME1 Gene

Protein Domains for NME1 Gene

Suggested Antigen Peptide Sequences for NME1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15531

UniProtKB/Swiss-Prot:

NDKA_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME1: view

Function for NME1 Gene

Molecular function for NME1 Gene

GENATLAS Biochemistry:
non-metastatic cells 1,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of nucleoside diphosphates,with a reduced expression in tumor progression to the metastatic phenotype,mutated in agressive neuroblastoma,expressed in lung carcinoma cell lines not in normal lung,pyrimidine biosynthetic pathway
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Autophosphorylation at His-118 increases serine/threonine protein kinase activity of the enzyme. Interaction with the SET complex inhibits the endonuclease activity.
UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3-5 exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3 end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

Enzyme Numbers (IUBMB) for NME1 Gene

Gene Ontology (GO) - Molecular Function for NME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 11555662
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0003697 single-stranded DNA binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0004536 deoxyribonuclease activity IDA 11555662
genes like me logo Genes that share ontologies with NME1: view
genes like me logo Genes that share phenotypes with NME1: view

Human Phenotype Ontology for NME1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NME1 Gene

MGI Knock Outs for NME1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NME1

CRISPR Products

miRNA for NME1 Gene

miRTarBase miRNAs that target NME1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NME1
  • Applied Biological Materials Clones for NME1

No data available for Transcription Factor Targets and HOMER Transcription for NME1 Gene

Localization for NME1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NME1 Gene

Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NME1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for NME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 16130169
GO:0005737 cytoplasm TAS 16130169
GO:0005741 mitochondrial outer membrane IEA --
GO:0005813 centrosome IEA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with NME1: view

Pathways & Interactions for NME1 Gene

genes like me logo Genes that share pathways with NME1: view

SIGNOR curated interactions for NME1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002762 negative regulation of myeloid leukocyte differentiation IEA --
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
genes like me logo Genes that share ontologies with NME1: view

Drugs & Compounds for NME1 Gene

(44) Drugs for NME1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adefovir Dipivoxil Approved, Investigational Pharma Enzyme, substrate 134
Lamivudine Approved, Investigational Pharma Enzyme, substrate Nucleoside analog reverse transcriptase inhibitor 621
Tenofovir Approved, Investigational Pharma Enzyme, substrate HIV reverse transcriptase inhibitor 759
Adenosine triphosphate Approved Nutra 0
dgtp Experimental Pharma Target 0

(42) Additional Compounds for NME1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
2'-Deoxyinosine triphosphate
  • 2'-Deoxy-Inosine 5'-(tetrahydrogen triphosphate)
  • 2'-Deoxyinosine-5'-triphosphate
  • 2'-Ditp
  • Deoxyinosine 5'-triphosphate
  • Deoxyinosine triphosphate
16595-02-1
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
1173-82-6
genes like me logo Genes that share compounds with NME1: view

Transcripts for NME1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NME1
  • Applied Biological Materials Clones for NME1

Alternative Splicing Database (ASD) splice patterns (SP) for NME1 Gene

No ASD Table

Relevant External Links for NME1 Gene

GeneLoc Exon Structure for
NME1
ECgene alternative splicing isoforms for
NME1

Expression for NME1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NME1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NME1 Gene

This gene is overexpressed in Amniocyte (10.9), Lavage (6.5), and Liver, secretome (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NME1 Gene



Protein tissue co-expression partners for NME1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NME1 Gene:

NME1

mRNA Expression by UniProt/SwissProt for NME1 Gene:

P15531-NDKA_HUMAN
Tissue specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation.

Evidence on tissue expression from TISSUES for NME1 Gene

  • Nervous system(4.6)
  • Lung(4.5)
  • Lymph node(3.4)
  • Liver(3.2)
  • Intestine(3)
  • Heart(2.4)
  • Kidney(2.3)
  • Thyroid gland(2.3)
  • Skin(2.2)
  • Bone marrow(2.1)
  • Muscle(2.1)
  • Spleen(2.1)
  • Stomach(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NME1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • heart
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • adrenal gland
  • intestine
  • kidney
  • large intestine
  • small intestine
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • spinal cord
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with NME1: view

No data available for mRNA differential expression in normal tissues for NME1 Gene

Orthologs for NME1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NME1 34 35
  • 99.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NME1 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NME1 34 35
  • 89.04 (n)
dog
(Canis familiaris)
Mammalia NME1 34 35
  • 88.6 (n)
-- 35
  • 88 (a)
OneToMany
-- 35
  • 88 (a)
OneToMany
-- 35
  • 83 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nme1 34
  • 88.16 (n)
mouse
(Mus musculus)
Mammalia Nme1 34 16 35
  • 87.72 (n)
oppossum
(Monodelphis domestica)
Mammalia NME1 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves NME2 35
  • 87 (a)
ManyToMany
NME1 34 35
  • 75.68 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nme2b.2 35
  • 78 (a)
ManyToMany
nme2b.1 34
  • 77.48 (n)
nme2a 35
  • 71 (a)
ManyToMany
CABZ01038708.1 35
  • 61 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.221 34
fruit fly
(Drosophila melanogaster)
Insecta awd 36 35
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea F25H2.5 36
  • 66 (a)
ndk-1 35
  • 66 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 35
  • 59 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G23900 34
  • 63.56 (n)
rice
(Oryza sativa)
Liliopsida Os05g0595400 34
  • 60.89 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.4469 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 68 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8138 34
Species where no ortholog for NME1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NME1 Gene

ENSEMBL:
Gene Tree for NME1 (if available)
TreeFam:
Gene Tree for NME1 (if available)

Paralogs for NME1 Gene

Paralogs for NME1 Gene

(7) SIMAP similar genes for NME1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for NME1 Gene

genes like me logo Genes that share paralogs with NME1: view

Variants for NME1 Gene

Sequence variations from dbSNP and Humsavar for NME1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000492510 -- 51,151,603(+) AAATA(A/C)ATAAA upstream-variant-2KB
rs1000530944 -- 51,156,408(+) TGGGT(A/G)AGGCA intron-variant
rs1000652012 -- 51,155,424(+) AAAAT(-/AAATC)AAATG intron-variant
rs1000668282 -- 51,156,083(+) TTTGA(G/T)TTCTT intron-variant
rs1000931976 -- 51,162,040(+) ATAGG(A/T)TTCAT intron-variant, utr-variant-3-prime

Variation tolerance for NME1 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NME1 Gene

Human Gene Mutation Database (HGMD)
NME1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NME1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NME1 Gene

Disorders for NME1 Gene

MalaCards: The human disease database

(33) MalaCards diseases for NME1 Gene - From: OMIM, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
anal canal carcinoma
  • anal canal and perianal gland carcinoma
larynx cancer
  • laryngeal benign neoplasm
lung giant cell carcinoma
  • giant cell carcinoma
hypopharynx cancer
  • hypopharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards
Search NME1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NME1

Genetic Association Database (GAD)
NME1
Human Genome Epidemiology (HuGE) Navigator
NME1
Tumor Gene Database (TGDB):
NME1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NME1
genes like me logo Genes that share disorders with NME1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NME1 Gene

Publications for NME1 Gene

  1. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL- mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. (PMID: 12628186) Fan Z. … Lieberman J. (Cell 2003) 3 4 22 64
  2. Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells. (PMID: 8810265) MacDonald N.J. … Steeg P.S. (J. Biol. Chem. 1996) 3 4 22 64
  3. Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. (PMID: 8270257) Dooley S. … Welter C. (Hum. Genet. 1994) 2 3 4 64
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64

Products for NME1 Gene