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Aliases for NMD3 Gene

Aliases for NMD3 Gene

  • NMD3 Ribosome Export Adaptor 2 3
  • HNMD3 3 4
  • 60S Ribosomal Export Protein NMD3 3
  • NMD3 Homolog (S. Cerevisiae) 2
  • NMD3 Homolog 3
  • CGI-07 3

External Ids for NMD3 Gene

Previous GeneCards Identifiers for NMD3 Gene

  • GC03P162422
  • GC03P160822
  • GC03P158337

Summaries for NMD3 Gene

Entrez Gene Summary for NMD3 Gene

  • Ribosomes are composed of 60S and 40S subunits that are assembled in the nucleolus and exported to the cytoplasm through nuclear pore complexes in the nuclear envelope. NMD3 is an adaptor for 60S subunit export via the CRM1 (XPO1; MIM 602559) pathway (Trotta et al., 2003 [PubMed 12773398]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NMD3 Gene

NMD3 (NMD3 Ribosome Export Adaptor) is a Protein Coding gene. Among its related pathways are RNA transport and Ribosome biogenesis in eukaryotes.

UniProtKB/Swiss-Prot for NMD3 Gene

  • Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.

Gene Wiki entry for NMD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMD3 Gene

Genomics for NMD3 Gene

Regulatory Elements for NMD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NMD3 Gene

Start:
161,104,696 bp from pter
End:
161,253,532 bp from pter
Size:
148,837 bases
Orientation:
Plus strand

Genomic View for NMD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NMD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMD3 Gene

Proteins for NMD3 Gene

  • Protein details for NMD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D46-NMD3_HUMAN
    Recommended name:
    60S ribosomal export protein NMD3
    Protein Accession:
    Q96D46
    Secondary Accessions:
    • D3DNM7
    • Q9Y2Z6

    Protein attributes for NMD3 Gene

    Size:
    503 amino acids
    Molecular mass:
    57603 Da
    Quaternary structure:
    • Found in a 60S ribosomal subunit export complex with RAN and XPO1. Interacts with XPO1. Associates with the 60S ribosomal subunit.

neXtProt entry for NMD3 Gene

Proteomics data for NMD3 Gene at MOPED

Post-translational modifications for NMD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NMD3 Gene

Domains for NMD3 Gene

Protein Domains for NMD3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NMD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96D46

UniProtKB/Swiss-Prot:

NMD3_HUMAN :
  • Q96D46
Family:
  • Belongs to the NMD3 family.
genes like me logo Genes that share domains with NMD3: view

No data available for Gene Families for NMD3 Gene

Function for NMD3 Gene

Molecular function for NMD3 Gene

UniProtKB/Swiss-Prot Function: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.

Gene Ontology (GO) - Molecular Function for NMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030674 protein binding, bridging IDA 12773398
GO:0043023 ribosomal large subunit binding IDA 12773398
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NMD3: view

Phenotypes for NMD3 Gene

genes like me logo Genes that share phenotypes with NMD3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NMD3 Gene

Localization for NMD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMD3 Gene

Cytoplasm. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMD3 Gene COMPARTMENTS Subcellular localization image for NMD3 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA 12773398
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 12773398
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NMD3: view

Pathways for NMD3 Gene

genes like me logo Genes that share pathways with NMD3: view

Pathways by source for NMD3 Gene

2 KEGG pathways for NMD3 Gene

Gene Ontology (GO) - Biological Process for NMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000055 ribosomal large subunit export from nucleus IMP 12773398
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with NMD3: view

Transcripts for NMD3 Gene

Unigene Clusters for NMD3 Gene

NMD3 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NMD3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMD3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for NMD3 Gene

GeneLoc Exon Structure for
NMD3
ECgene alternative splicing isoforms for
NMD3

Expression for NMD3 Gene

mRNA expression in normal human tissues for NMD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NMD3 Gene

SOURCE GeneReport for Unigene cluster for NMD3 Gene Hs.598836

genes like me logo Genes that share expressions with NMD3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NMD3 Gene

Orthologs for NMD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NMD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMD3 35
  • 99.73 (n)
  • 99.6 (a)
NMD3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NMD3 35
  • 92.64 (n)
  • 94.83 (a)
NMD3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMD3 35
  • 92.51 (n)
  • 95.03 (a)
NMD3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmd3 35
  • 91.39 (n)
  • 94.83 (a)
Nmd3 16
Nmd3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMD3 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMD3 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmd3 35
  • 91.39 (n)
  • 94.83 (a)
chicken
(Gallus gallus)
Aves NMD3 35
  • 77 (n)
  • 81.11 (a)
NMD3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMD3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmd3 35
  • 75.48 (n)
  • 82.9 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8390 35
zebrafish
(Danio rerio)
Actinopterygii nmd3 35
  • 69.65 (n)
  • 77.49 (a)
nmd3 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005375 35
  • 56.18 (n)
  • 54.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nmd3 35
  • 56.04 (n)
  • 54.45 (a)
Nmd3 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T25G3.3 35
  • 56.03 (n)
  • 52.35 (a)
T25G3.3 36
  • 49 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER299C 35
  • 54.57 (n)
  • 49.78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMD3 35
  • 54.75 (n)
  • 47.45 (a)
NMD3 36
  • 42 (a)
OneToOne
NMD3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05159g 35
  • 54.62 (n)
  • 48.11 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G03820 35
  • 54.09 (n)
  • 46.06 (a)
rice
(Oryza sativa)
Liliopsida Os10g0573900 35
  • 46.76 (n)
  • 41.13 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08663 35
  • 49.75 (n)
  • 45.82 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nmd3 35
  • 54.68 (n)
  • 49.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6714 36
  • 54 (a)
OneToOne
Species with no ortholog for NMD3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMD3 Gene

ENSEMBL:
Gene Tree for NMD3 (if available)
TreeFam:
Gene Tree for NMD3 (if available)

Paralogs for NMD3 Gene

Pseudogenes.org Pseudogenes for NMD3 Gene

genes like me logo Genes that share paralogs with NMD3: view

No data available for Paralogs for NMD3 Gene

Variants for NMD3 Gene

Sequence variations from dbSNP and Humsavar for NMD3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs4132373 -- 161,232,817(-) AAGGG(A/G)TGGGT intron-variant
rs4273380 -- 161,232,526(+) TATCC(A/G)TTGTT intron-variant
rs4290817 -- 161,249,566(+) GTCTC(A/G)CTTTT intron-variant
rs4350933 -- 161,238,091(+) TCATA(G/T)GGCTT intron-variant
rs4352387 -- 161,223,639(+) TTTAA(C/T)GTAGT intron-variant

Relevant External Links for NMD3 Gene

HapMap Linkage Disequilibrium report
NMD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NMD3 Gene

Disorders for NMD3 Gene

Relevant External Links for NMD3

Genetic Association Database (GAD)
NMD3
genes like me logo Genes that share disorders with NMD3: view

No data available for UniProtKB/Swiss-Prot for NMD3 Gene

Publications for NMD3 Gene

  1. Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates. (PMID: 12773398) Trotta C.R. … Dahlberg J.E. (EMBO J. 2003) 2 3 4 23
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  3. Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. (PMID: 12724356) Thomas F. … Kutay U. (J. Cell Sci. 2003) 3 4
  4. CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus and affect rRNA synthesis. (PMID: 23782956) Bai B. … Laiho M. (Nucleus 2013) 2 3
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for NMD3 Gene

Sources for NMD3 Gene

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