NMD3 Gene
protein-coding GIFtS: 52
GCID: GC03P160822
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NMD3 homolog (S. cerevisiae)
| |
Aliases for NMD3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| NMD3 Homolog (S. Cerevisiae)1 2 | | HNMD31 | | CGI-071 | | 60S Ribosomal Export Protein NMD32 |
Export aliases for NMD3 gene to outside databasesPrevious GC identifers: GC03P162422 GC03P158337 |
Summaries for NMD3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for NMD3: Ribosomes are composed of 60S and 40S subunits that are assembled in the nucleolus and exported to the cytoplasmthrough nuclear pore complexes in the nuclear envelope. NMD3 is an adaptor for 60S subunit export via the CRM1 (XPO1;MIM 602559) pathway (Trotta et al., 2003 (PubMed 12773398)).(supplied by OMIM, Mar 2008) UniProtKB/Swiss-Prot: NMD3_HUMAN, Q96D46Function: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit Gene Wiki entry for NMD3
|
Genomic Views for NMD3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NMD3 gene promoter: AML1a p53 Ik-3 HNF-1A HNF-1 POU2F1a POU2F1b POU2F1c Other transcription factors
Search SABiosciences Chromatin IP Primers for NMD3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMD3 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26.1 Ensembl cytogenetic band: 3q26.1 HGNC cytogenetic band: 3q26.1NMD3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P160822: view genomic region
(about GC identifiers)
Start:
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160,822,484 bp from pter |
End:
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160,971,320 bp from pter |
Size:
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148,837 bases |
Orientation:
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plus strand |
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Proteins for NMD3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: NMD3_HUMAN, Q96D46 (See
protein sequence)Recommended Name: 60S ribosomal export protein NMD3 Size: 503 amino acids; 57603 Da
Subunit: Found in a 60S ribosomal subunit export complex with RAN and XPO1. Interacts with XPO1. Associates with the60S ribosomal subunit
Subcellular location: Cytoplasm. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus/nucleolusand the cytoplasm in a XPO1/CRM1-dependent manner
Secondary accessions: D3DNM7 Q9Y2Z6Explore the universe of human proteins at neXtProt for NMD3: NX_Q96D46
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96D46 NMD3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057022.2 ENSEMBL proteins: ENSP00000418852 ENSP00000418980 ENSP00000419030 ENSP00000307525 ENSP00000417559 ENSP00000418908 ENSP00000419647 ENSP00000419004 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
NMD3 for ontologies About GeneDecksing
NMD3 Antibody Products: Assay Products for NMD3: |
Protein
Domains / Families for NMD3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NMD3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96D46ProtoNet protein and cluster: Q96D46 1 Blocks protein family: IPB007064 NMD3 family
UniProtKB/Swiss-Prot: NMD3_HUMAN, Q96D46Similarity: Belongs to the NMD3 family |
Function for NMD3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: NMD3_HUMAN, Q96D46Function: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NMD3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NMD3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NMD3 (NM_015938) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NMD3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMD3  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMD3 |
2 GenomeRNAi human phenotypes for NMD3:
|
Pathways & Interactions for NMD3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ribosome biogenesis in eukaryotes | | | 2 | RNA transport | |
Pathway sources See GeneCards unified pathways Show all pathways
2
Kegg Pathways (Kegg details for NMD3):
NMD3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NMD3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/150 Interacting proteins for NMD3 (Q96D463 ENSP000003075254) via UniProtKB, MINT, STRING, and/or I2D (see all 150)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- |
NMD3 for ontologies About GeneDecksing
|
Drugs & Compounds for NMD3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for NMD3 Search CenterWatch for drugs/clinical trials and news about NMD3 
|
Transcripts for NMD3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for NMD3 gene: NM_015938.3 Unigene Cluster for NMD3: NMD3 homolog (S. cerevisiae) Hs.598836 [show with all ESTs]Unigene Representative Sequence: AK09474910 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000468606 ENST00000460503 ENST00000493066 ENST00000473909 ENST00000351193(uc003feb.1) ENST00000472947(uc003fec.3 uc010hwh.3) ENST00000463518 ENST00000476237 ENST00000460469(uc003fed.1) ENST00000478160
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NMD3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NMD3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NMD3 (NM_015938) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NMD3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMD3  |
Additional cDNA sequence: AF132941.1 AK021775.1 AK024706.1 AK094749.1 AK225664.1 AK296710.1 AK308865.1 BC013317.1 16 DOTS entries: DT.312721 DT.91863039 DT.100780630 DT.95126351 DT.100780633 DT.40118028 DT.120873418 DT.100709289 DT.120873409 DT.92447739 DT.95247758 DT.120873386 DT.120873392 DT.121053518 DT.97768262 DT.95254327 24/252 AceView cDNA sequences (see all 252): BG111022 BM751006 AV703519 CF272477 CB177800 BP359754 CB177429 AL559741 BQ433999 CB117272 AI004325 AI219257 AI687171 BF511033 AA282197 BG527444 CR591426 BM999516 BP379771 BF969556 AA425145 BU508414 BC013317 BU679087 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NMD3 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | |
| SP1: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for NMD3
|
Expression for NMD3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NMD3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See NMD3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NMD3
SOURCE GeneReport for Unigene cluster: Hs.598836 SABiosciences Custom PCR Arrays for NMD3
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NMD3 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NMD3 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMD3 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMD3 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMD3 |
Orthologs for NMD3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NMD3 gene from 10/35 species (see all 35) About this table
ENSEMBL Gene Tree for NMD3 (if available) TreeFam Gene Tree for NMD3 (if available)  |
Paralogs for NMD3 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for NMD3 gene
NMD3 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for NMD3 PGOHUM00000232726 PGOHUM00000232802
|
Genomic Variants for NMD3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for NMD3 (160822484 - 160971320 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for NMD3: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NMD3 |
|
Disorders
/ Diseases for NMD3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NMD3 for disorders About GeneDecksing
OMIM gene information: 611021
OMIM disorders: --
1 disease for NMD3: About MalaCardsmalaria Export disorders for NMD3 gene to outside databases
|
Publications for NMD3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NMD3 gene, integrated from 9 sources (see all 19): (articles sorted by number of sources associating them with NMD3) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates. (PubMed id 12773398)1, 2, 3, 9 Trotta C.R....Dahlberg J.E. (2003)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. (PubMed id 12724356)1, 2 Thomas F. and Kutay U. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A protein inventory of human ribosome biogenesis reve als an essential function of exportin 5 in 60S subunit export. (PubMed id 21048991)1 Wild T....Kutay U. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for NMD3 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NMD3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NMD3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NMD3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for NMD3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NMD3 gene: Search GeneIP for patents involving NMD3
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for NMD3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | OriGene Custom Antibody Services for NMD3 | | OriGene Custom Protein Services for NMD3 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NMD3 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NMD3 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMD3 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMD3 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMD3 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMD3 |
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| | | Search Tocris compounds for NMD3 |
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 | | NMD3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMD3 |
|  |  |  | | | ThermoFisher Antibodies for NMD3 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMD3 |
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