Aliases for NMBR Gene
External Ids for NMBR Gene
Previous GeneCards Identifiers for NMBR Gene
Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue. [provided by RefSeq, Jul 2008]
GeneCards Summary for NMBR Gene
NMBR (Neuromedin B Receptor) is a Protein Coding gene. Diseases associated with NMBR include lung cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include bombesin receptor activity. An important paralog of this gene is EDNRB.
UniProtKB/Swiss-Prot for NMBR Gene
Receptor for neuromedin-B
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor (BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The receptors are Gq/11-coupled and are involved in the regulation of many biological functions including sensory transmission, thermoregulation, feeding, pituitary, gastric and pancreatic secretion. They may also be involved in tissue development, proliferation and differentiation.