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Aliases for NMBR Gene

Aliases for NMBR Gene

  • Neuromedin B Receptor 2 3
  • Neuromedin-B-Preferring Bombesin Receptor 3 4
  • Epididymis Tissue Protein Li 185a 3 4
  • Bombesin Receptor 1 2 3
  • NMB-R 3 4
  • Neuromedin-B Receptor 3
  • BB1 3

External Ids for NMBR Gene

Previous GeneCards Identifiers for NMBR Gene

  • GC06M142243
  • GC06M142377
  • GC06M142438
  • GC06M139962

Summaries for NMBR Gene

Entrez Gene Summary for NMBR Gene

  • Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue. [provided by RefSeq, Jul 2008]

GeneCards Summary for NMBR Gene

NMBR (Neuromedin B Receptor) is a Protein Coding gene. Diseases associated with NMBR include lung cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include bombesin receptor activity. An important paralog of this gene is EDNRB.

UniProtKB/Swiss-Prot for NMBR Gene

  • Receptor for neuromedin-B

Tocris Summary for NMBR Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor (BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The receptors are Gq/11-coupled and are involved in the regulation of many biological functions including sensory transmission, thermoregulation, feeding, pituitary, gastric and pancreatic secretion. They may also be involved in tissue development, proliferation and differentiation.

Gene Wiki entry for NMBR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMBR Gene

Genomics for NMBR Gene

Regulatory Elements for NMBR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NMBR Gene

Start:
142,058,330 bp from pter
End:
142,088,799 bp from pter
Size:
30,470 bases
Orientation:
Minus strand

Genomic View for NMBR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NMBR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMBR Gene

Proteins for NMBR Gene

  • Protein details for NMBR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28336-NMBR_HUMAN
    Recommended name:
    Neuromedin-B receptor
    Protein Accession:
    P28336
    Secondary Accessions:
    • E9KL38
    • Q5VUK8

    Protein attributes for NMBR Gene

    Size:
    390 amino acids
    Molecular mass:
    43435 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NMBR Gene

Proteomics data for NMBR Gene at MOPED

Post-translational modifications for NMBR Gene

  • Glycosylation at Asn8, Asn16, and Asn192
  • Modification sites at PhosphoSitePlus

Other Protein References for NMBR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NMBR Gene

Domains for NMBR Gene

Gene Families for NMBR Gene

HGNC:
  • BRS :GPCR / Class A : Bombesin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for NMBR Gene

Graphical View of Domain Structure for InterPro Entry

P28336

UniProtKB/Swiss-Prot:

NMBR_HUMAN :
  • P28336
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NMBR: view

Function for NMBR Gene

Molecular function for NMBR Gene

GENATLAS Biochemistry: neuromedin B receptor, G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for neuromedin-B

Gene Ontology (GO) - Molecular Function for NMBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004946 bombesin receptor activity IEA --
genes like me logo Genes that share ontologies with NMBR: view

Phenotypes for NMBR Gene

genes like me logo Genes that share phenotypes with NMBR: view

Animal Models for NMBR Gene

MGI Knock Outs for NMBR:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NMBR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NMBR Gene

Localization for NMBR Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMBR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMBR Gene COMPARTMENTS Subcellular localization image for NMBR gene
Compartment Confidence
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for NMBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8391296
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NMBR: view

Pathways for NMBR Gene

genes like me logo Genes that share pathways with NMBR: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NMBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 1655761
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 7838118
GO:0031989 bombesin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with NMBR: view

Compounds for NMBR Gene

(5) Tocris Compounds for NMBR Gene

Compound Action Cas Number
BIM 23042 Selective neuromedin B receptor antagonist (NMB-R, BB1) [111857-96-6]
Bombesin Involved in gastrointestinal tract function [31362-50-2]
GRP (human) Endogenous GRP receptor agonist [93755-85-2]
GRP (porcine) Endogenous GRP receptor agonist [74815-57-9]
PD 176252 GRP (BB2) and NMB (BB1) receptor antagonist [204067-01-6]

(19) IUPHAR Ligand for NMBR Gene

Ligand Type Action Affinity Pubmed IDs
[D-Phe6,beta-Ala11,Phe13,Nle14]bombesin-(6-14) Agonist Full agonist 10.32
gastrin releasing peptide (14-27) (human) Agonist Full agonist 9.77
bombesin Agonist Full agonist 8.85
ranatensin Agonist Full agonist 8.65
PD 165929 Antagonist Antagonist 8.2
[125I][Tyr4]bombesin Agonist Full agonist 8.2
neuromedin B Agonist Full agonist 8.13
neuromedin B (1-30) (human) Agonist Full agonist 7.82
Rhodei-litorin Agonist Full agonist 6.96
PD 176252 Antagonist Antagonist 6.77
[Leu8]-phyllolitorin Agonist Full agonist 6.43
PD 168368 Antagonist Antagonist 5.93
D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Nal-NH2 Antagonist Antagonist 5.61
phyllolitorin Agonist Full agonist 5.52
D-Nal,Cys,Tyr,D-Trp,Orn,Val,Cys,Nal-NH2 Antagonist Antagonist 5.46
bantag-1 Antagonist Antagonist 5.36
MK-5046 Agonist Full agonist 5
[125I]BH-NMB None None
dNal-cyc(Cys-Tyr-dTrp-Orn-Val)-Nal-NH2 Antagonist Antagonist

(3) Novoseek inferred chemical compound relationships for NMBR Gene

Compound -log(P) Hits PubMed IDs
ranatensin 88.2 1
inositol 1,4,5 trisphosphate 19.8 1
calcium 6.66 3
genes like me logo Genes that share compounds with NMBR: view

Transcripts for NMBR Gene

mRNA/cDNA for NMBR Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NMBR Gene

Neuromedin B receptor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NMBR

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NMBR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMBR Gene

No ASD Table

Relevant External Links for NMBR Gene

GeneLoc Exon Structure for
NMBR
ECgene alternative splicing isoforms for
NMBR

Expression for NMBR Gene

mRNA expression in normal human tissues for NMBR Gene

mRNA differential expression in normal tissues according to GTEx for NMBR Gene

This gene is overexpressed in Testis (7.3), Brain - Nucleus accumbens (basal ganglia) (5.9), Brain - Hypothalamus (4.6), and Brain - Caudate (basal ganglia) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NMBR Gene

SOURCE GeneReport for Unigene cluster for NMBR Gene Hs.654478

mRNA Expression by UniProt/SwissProt for NMBR Gene

P28336-NMBR_HUMAN
Tissue specificity: Expressed in epididymis (at protein level).
genes like me logo Genes that share expressions with NMBR: view

In Situ Assay Products

Orthologs for NMBR Gene

This gene was present in the common ancestor of animals.

Orthologs for NMBR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMBR 35
  • 99.15 (n)
  • 98.21 (a)
NMBR 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NMBR 35
  • 88.97 (n)
  • 91.54 (a)
NMBR 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMBR 35
  • 89.66 (n)
  • 89.74 (a)
NMBR 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmbr 35
  • 86.32 (n)
  • 90.51 (a)
Nmbr 16
Nmbr 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMBR 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMBR 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmbr 35
  • 85.73 (n)
  • 89.23 (a)
chicken
(Gallus gallus)
Aves NMBR 35
  • 73.83 (n)
  • 74.87 (a)
NMBR 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMBR 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nmbr 36
  • 60 (a)
OneToOne
nmbrl 35
  • 65.01 (n)
  • 71.07 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRGRP1 35
  • 48.94 (n)
  • 37.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CCHa1r 35
  • 46.63 (n)
  • 38.15 (a)
CCHa1r 36
  • 27 (a)
ManyToMany
CCHa2r 36
  • 27 (a)
ManyToMany
CG30106 37
  • 36 (a)
Species with no ortholog for NMBR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMBR Gene

ENSEMBL:
Gene Tree for NMBR (if available)
TreeFam:
Gene Tree for NMBR (if available)

Paralogs for NMBR Gene

Paralogs for NMBR Gene

Selected SIMAP similar genes for NMBR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NMBR: view

Variants for NMBR Gene

Sequence variations from dbSNP and Humsavar for NMBR Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3811087 -- 142,088,832(+) GAGGG(A/G)TCTGT upstream-variant-2KB
rs3811088 -- 142,088,975(+) CTAGC(A/G)GAAAA upstream-variant-2KB
rs3811089 -- 142,090,530(+) attaa(C/G)attag upstream-variant-2KB
rs4272230 -- 142,080,559(+) ctgcc(A/G)acctc intron-variant
rs4413630 -- 142,085,425(+) AGGTT(G/T)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMBR Gene

Variant ID Type Subtype PubMed ID
dgv7003n71 CNV Gain 21882294
nsv464069 CNV Gain 19166990
dgv7004n71 CNV Loss 21882294
nsv830824 CNV Gain 17160897
nsv886735 CNV Loss 21882294

Relevant External Links for NMBR Gene

HapMap Linkage Disequilibrium report
NMBR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMBR Gene

Disorders for NMBR Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NMBR Gene including...

Search for NMBR Gene in MalaCards »

(9) Novoseek inferred disease relationships for NMBR Gene

Disease -log(P) Hits PubMed IDs
small cell lung cancer 57.7 2
lung carcinoma 43.5 1
carcinoma non-small cell lung 38.6 1
prostate cancer 29.2 1
nsclc 28.7 4

Relevant External Links for NMBR

Genetic Association Database (GAD)
NMBR
Human Genome Epidemiology (HuGE) Navigator
NMBR
genes like me logo Genes that share disorders with NMBR: view

No data available for UniProtKB/Swiss-Prot for NMBR Gene

Publications for NMBR Gene

  1. Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. (PMID: 1655761) Corjay M.H. … Battey J.F. (J. Biol. Chem. 1991) 3 4 23
  2. Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides. (PMID: 8391296) Giladi E. … Spindel E.R. (J. Mol. Neurosci. 1993) 3 23
  3. The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding. (PMID: 8392057) Fathi Z. … Battey J.F. (J. Biol. Chem. 1993) 3 23
  4. Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor. (PMID: 9632639) Sainz E. … Battey J.F. (J. Biol. Chem. 1998) 3 23
  5. Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. (PMID: 15528253) Matusiak D. … Benya R.V. (Am. J. Physiol. Gastrointest. Liver Physiol. 2005) 3 23

Products for NMBR Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NMBR
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NMBR
    • Block miRNA regulation of NMBR using miScript Target Protectors

    Sources for NMBR Gene

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