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Aliases for NMBR Gene

Aliases for NMBR Gene

  • Neuromedin B Receptor 2 3 5
  • Neuromedin-B-Preferring Bombesin Receptor 3 4
  • Epididymis Tissue Protein Li 185a 3 4
  • Bombesin Receptor 1 2 3
  • NMB-R 3 4
  • Epididymis Secretory Sperm Binding Protein Li 185a 3
  • BB1 3

External Ids for NMBR Gene

Previous GeneCards Identifiers for NMBR Gene

  • GC06M142243
  • GC06M142377
  • GC06M142438
  • GC06M139962

Summaries for NMBR Gene

Entrez Gene Summary for NMBR Gene

  • This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

GeneCards Summary for NMBR Gene

NMBR (Neuromedin B Receptor) is a Protein Coding gene. Diseases associated with NMBR include lung cancer and small cell cancer of the lung, somatic. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and bombesin receptor activity. An important paralog of this gene is EDNRB.

UniProtKB/Swiss-Prot for NMBR Gene

  • Receptor for neuromedin-B.

Tocris Summary for NMBR Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

Gene Wiki entry for NMBR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMBR Gene

Genomics for NMBR Gene

Regulatory Elements for NMBR Gene

Promoters for NMBR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NMBR on UCSC Golden Path with GeneCards custom track

Genomic Location for NMBR Gene

Chromosome:
6
Start:
142,058,330 bp from pter
End:
142,147,118 bp from pter
Size:
88,789 bases
Orientation:
Minus strand

Genomic View for NMBR Gene

Genes around NMBR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMBR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMBR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMBR Gene

Proteins for NMBR Gene

  • Protein details for NMBR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28336-NMBR_HUMAN
    Recommended name:
    Neuromedin-B receptor
    Protein Accession:
    P28336
    Secondary Accessions:
    • E9KL38
    • Q5VUK8

    Protein attributes for NMBR Gene

    Size:
    390 amino acids
    Molecular mass:
    43435 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NMBR Gene

Proteomics data for NMBR Gene at MOPED

Post-translational modifications for NMBR Gene

  • Glycosylation at Asn 8, Asn 16, and Asn 192
  • Modification sites at PhosphoSitePlus

Other Protein References for NMBR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NMBR (Neuromedin B R/NMBR)

No data available for DME Specific Peptides for NMBR Gene

Domains & Families for NMBR Gene

Gene Families for NMBR Gene

Suggested Antigen Peptide Sequences for NMBR Gene

Graphical View of Domain Structure for InterPro Entry

P28336

UniProtKB/Swiss-Prot:

NMBR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NMBR: view

Function for NMBR Gene

Molecular function for NMBR Gene

GENATLAS Biochemistry:
neuromedin B receptor, G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for neuromedin-B.
genes like me logo Genes that share phenotypes with NMBR: view

Animal Models for NMBR Gene

MGI Knock Outs for NMBR:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NMBR Gene

Localization for NMBR Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMBR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMBR Gene COMPARTMENTS Subcellular localization image for NMBR gene
Compartment Confidence
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NMBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NMBR: view

Pathways & Interactions for NMBR Gene

genes like me logo Genes that share pathways with NMBR: view

SIGNOR curated interactions for NMBR Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NMBR Gene

None

Drugs & Compounds for NMBR Gene

(20) Drugs for NMBR Gene - From: IUPHAR, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bombesin Pharma Full agonist, Agonist Involved in gastrointestinal tract function 7
ranatensin Pharma Full agonist, Agonist 0
[<sup>125</sup>I][Tyr<sup>4</sup>]bombesin Pharma Full agonist, Agonist 0
[Leu<sup>8</sup>]-phyllolitorin Pharma Full agonist, Agonist 0
bantag-1 Pharma Antagonist 0

(8) Additional Compounds for NMBR Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]BH-NMB
[D-Phe<sup>6</sup>,beta-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14)
Full agonist, Agonist
gastrin releasing peptide (14-27) (human)
Full agonist, Agonist
BA 1
183241-31-8
BIM 187
137734-88-4
genes like me logo Genes that share compounds with NMBR: view

Transcripts for NMBR Gene

mRNA/cDNA for NMBR Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NMBR Gene

Neuromedin B receptor:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMBR Gene

No ASD Table

Relevant External Links for NMBR Gene

GeneLoc Exon Structure for
NMBR
ECgene alternative splicing isoforms for
NMBR

Expression for NMBR Gene

mRNA expression in normal human tissues for NMBR Gene

mRNA differential expression in normal tissues according to GTEx for NMBR Gene

This gene is overexpressed in Testis (x7.3), Brain - Nucleus accumbens (basal ganglia) (x5.9), Brain - Hypothalamus (x4.6), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for NMBR Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NMBR Gene



SOURCE GeneReport for Unigene cluster for NMBR Gene Hs.654478

mRNA Expression by UniProt/SwissProt for NMBR Gene

P28336-NMBR_HUMAN
Tissue specificity: Expressed in epididymis (at protein level).
genes like me logo Genes that share expression patterns with NMBR: view

Protein tissue co-expression partners for NMBR Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NMBR Gene

This gene was present in the common ancestor of animals.

Orthologs for NMBR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMBR 36
  • 98 (a)
OneToOne
NMBR 35
  • 99.15 (n)
  • 98.21 (a)
cow
(Bos Taurus)
Mammalia NMBR 35
  • 88.97 (n)
  • 91.54 (a)
NMBR 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMBR 36
  • 90 (a)
OneToOne
NMBR 35
  • 89.66 (n)
  • 89.74 (a)
mouse
(Mus musculus)
Mammalia Nmbr 36
  • 91 (a)
OneToOne
Nmbr 16
Nmbr 35
  • 86.32 (n)
  • 90.51 (a)
oppossum
(Monodelphis domestica)
Mammalia NMBR 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMBR 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmbr 35
  • 85.73 (n)
  • 89.23 (a)
chicken
(Gallus gallus)
Aves NMBR 35
  • 73.83 (n)
  • 74.87 (a)
NMBR 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMBR 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nmbrl 35
  • 65.01 (n)
  • 71.07 (a)
nmbr 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GPRGRP1 35
  • 48.94 (n)
  • 37.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30106 37
  • 36 (a)
CCHa1r 35
  • 46.63 (n)
  • 38.15 (a)
CCHa1r 36
  • 27 (a)
ManyToMany
CCHa2r 36
  • 27 (a)
ManyToMany
Species with no ortholog for NMBR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMBR Gene

ENSEMBL:
Gene Tree for NMBR (if available)
TreeFam:
Gene Tree for NMBR (if available)

Paralogs for NMBR Gene

Paralogs for NMBR Gene

(8) SIMAP similar genes for NMBR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NMBR: view

Variants for NMBR Gene

Sequence variations from dbSNP and Humsavar for NMBR Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs7453944 - 142,075,653(+) TCACA(A/G/T)TGCCA reference, missense
rs2717 -- 142,074,583(+) CATTT(A/G)TTCAG utr-variant-3-prime
rs225593 -- 142,122,371(+) tacct(G/T)gtaat intron-variant
rs225594 -- 142,122,393(+) tatca(C/T)catac intron-variant
rs225595 -- 142,122,853(+) tcaaa(A/G)tatta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMBR Gene

Variant ID Type Subtype PubMed ID
dgv7003n71 CNV Gain 21882294
nsv464069 CNV Gain 19166990
dgv7004n71 CNV Loss 21882294
nsv830824 CNV Gain 17160897
nsv886735 CNV Loss 21882294

Variation tolerance for NMBR Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.84; 79.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMBR Gene

HapMap Linkage Disequilibrium report
NMBR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMBR Gene

Disorders for NMBR Gene

MalaCards: The human disease database

(2) MalaCards diseases for NMBR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
small cell cancer of the lung, somatic
  • lung small cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search NMBR in MalaCards View complete list of genes associated with diseases

Relevant External Links for NMBR

Genetic Association Database (GAD)
NMBR
Human Genome Epidemiology (HuGE) Navigator
NMBR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMBR
genes like me logo Genes that share disorders with NMBR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMBR Gene

Publications for NMBR Gene

  1. Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. (PMID: 1655761) Corjay M.H. … Battey J.F. (J. Biol. Chem. 1991) 3 4 23 67
  2. Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. (PMID: 15528253) Matusiak D. … Benya R.V. (Am. J. Physiol. Gastrointest. Liver Physiol. 2005) 3 23
  3. Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study. (PMID: 15634004) Nock B.A. … Maina T. (J. Med. Chem. 2005) 3 23
  4. Identification and optimization of novel partial agonists of neuromedin B receptor using parallel synthesis. (PMID: 15149640) Shuttleworth S.J. … Coward P. (Bioorg. Med. Chem. Lett. 2004) 3 23
  5. Detection of tumor specific gene expression in bone marrow and peripheral blood from patients with small cell lung carcinoma. (PMID: 12569606) Shingyoji M. … Kuriyama T. (Cancer 2003) 3 23

Products for NMBR Gene

Sources for NMBR Gene

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