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NMBR Gene

protein-coding   GIFtS: 66
GCID: GC06M142438

Neuromedin B Receptor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Neuromedin B Receptor1 2     NMB-R2 3
Bombesin Receptor 11 2     BB12
Epididymis Tissue Protein Li 185a2 3     Neuromedin-B Receptor2
Neuromedin-B-Preferring Bombesin Receptor2 3     

External Ids:    HGNC: 78431   Entrez Gene: 48292   Ensembl: ENSG000001355777   OMIM: 1623415   UniProtKB: P283363   
ORGUL members:         

Export aliases for NMBR gene to outside databases

Previous GC identifers: GC06M142019 GC06M142243 GC06M142377 GC06M139962


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NMBR Gene:
Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and
for gastrointestinal epithelial tissue. (provided by RefSeq, Jul 2008)

GeneCards Summary for NMBR Gene:
NMBR (neuromedin B receptor) is a protein-coding gene. Diseases associated with NMBR include ovarian epithelial cancer, and gastrinoma. GO annotations related to this gene include bombesin receptor activity. An important paralog of this gene is EDNRA.

UniProtKB/Swiss-Prot: NMBR_HUMAN, P28336
Function: Receptor for neuromedin-B

summary for NMBR Gene:
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B
(NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor
(BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The
receptors are Gq/11-coupled and are involved in the regulation of many biological functions including
sensory transmission, thermoregulation, feeding, pituitary, gastric and pancreatic secretion. They may also
be involved in tissue development, proliferation and differentiation.

Gene Wiki entry for NMBR (Neuromedin B receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NMBR gene promoter:
         p53   AML1a   Pax-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   c-Ets-1   FAC1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNMBR promoter sequence
   Search Chromatin IP Primers for NMBR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NMBR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.1   Ensembl cytogenetic band:  6q24.1   HGNC cytogenetic band: 6q24.1

NMBR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMBR gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M142438:  view genomic region     (about GC identifiers)

Start:
142,379,467 bp from pter      End:
142,409,936 bp from pter
Size:
30,470 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NMBR_HUMAN, P28336 (See protein sequence)
Recommended Name: Neuromedin-B receptor  
Size: 390 amino acids; 43435 Da
Secondary accessions: E9KL38 Q5VUK8

Explore the universe of human proteins at neXtProt for NMBR: NX_P28336

Explore proteomics data for NMBR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn8, Asn16, Asn192
  • Modification sites at PhosphoSitePlus

  • See NMBR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002502.2  
    ENSEMBL proteins: 
     ENSP00000258042  
    Reactome Protein details: P28336

    NMBR Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NMBR

    NMBR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals NMBR Antibodies
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    NMBR Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript NMBR-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NMBR
    Cloud-Clone Corp. CLIAs for NMBR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BRS: GPCR / Class A : Bombesin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: BB1 receptor
    Bombesin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR001642 NeuroB_rcpt
     IPR001556 Bombsn_rcpt

    Graphical View of Domain Structure for InterPro Entry P28336

    ProtoNet protein and cluster: P28336

    2 Blocks protein domains:
    IPB001556 Bombesin receptor signature
    IPB001642 Neuromedin B receptor signature


    UniProtKB/Swiss-Prot: NMBR_HUMAN, P28336
    Similarity: Belongs to the G-protein coupled receptor 1 family


    NMBR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMBR_HUMAN, P28336
    Function: Receptor for neuromedin-B

         Genatlas biochemistry entry for NMBR:
    neuromedin B receptor, G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004946bombesin receptor activity IEA--
         
    NMBR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NMBR:
     Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nmbr):
     behavior/neurological  homeostasis/metabolism 

    NMBR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nmbrtm1Hoh for NMBR

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NMBR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NMBR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NMBR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NMBR

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NMBR

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: NMBR (NM_002511)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMBR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMBR

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMBR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NMBR_HUMAN, P28336: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8391296
    GO:0016021integral component of membrane ----

    NMBR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NMBR About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NMBR
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for NMBR
        Peptide ligand-binding receptors
    G alpha (q) signalling events


    1 Kegg Pathway  (Kegg details for NMBR):
        Neuroactive ligand-receptor interaction


    NMBR for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NMBR: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NMBR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NMBR (P283363 ENSP000002580424) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NMBP089493, ENSP000003780894I2D: score=2 STRING: ENSP00000378089
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    AVPR1AENSP000002991784STRING: ENSP00000299178
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    CCKENSP000003356574STRING: ENSP00000335657
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS1655761
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway TAS7838118

    NMBR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NMBR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BombesinInvolved in gastrointestinal tract function[31362-50-2]
    PD 176252GRP (BB2) and NMB (BB1) receptor antagonist[204067-01-6]
    GRP (human)Endogenous GRP receptor agonist[93755-85-2]
    GRP (porcine)Endogenous GRP receptor agonist[74815-57-9]
    Neuromedin B (porcine)Mammalian bombesin-like peptide[87096-84-2]

    Selected IUPHAR Ligands for NMBR (BB1 receptor) (see all 19)    About this table
    LigandTypeActionAffinityPubmed IDs
    neuromedin B
    AgonistFull agonist8.1 - 10.310454496 7838118
    PD 176252
    AntagonistAntagonist9.28 - 9.7719463875
    Rhodei-litorin
    AgonistFull agonist9.59 - 9.7521729729
    neuromedin B (1-30) (human)
    AgonistFull agonist9.52 - 9.721729729
    [D-Phe6,beta-Ala11,Phe13,Nle14]bombesin-(6-14)
    AgonistFull agonist9.49 - 9.6821729729
    PD 168368
    AntagonistAntagonist9.24 - 9.619463875
    ranatensin
    AgonistFull agonist8.35 - 8.8321729729
    phyllolitorin
    AgonistFull agonist8.63 - 8.6421729729
    PD 165929
    AntagonistAntagonist8.2--
    bombesin
    AgonistFull agonist7.47 - 7.4910454496 7838118

    3 Novoseek inferred chemical compound relationships for NMBR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ranatensin 88.2 1 8788416 (1)
    inositol 1,4,5 trisphosphate 19.8 1 8806106 (1)
    calcium 6.66 3 8813645 (1), 8806106 (1), 9857994 (1)



    NMBR for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NMBR gene: 
    NM_002511.2  

    Unigene Cluster for NMBR:

    Neuromedin B receptor
    Hs.654478  [show with all ESTs]
    Unigene Representative Sequence: NM_002511
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480652 ENST00000258042(uc003qiu.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NMBR
      QuantiFast Probe-based Assays in human, mouse, rat NMBR

    Additional mRNA sequence: 

    BC095542.1 GU727635.1 M73482.1 

    1 DOTS entry:

    DT.311274 

    17 AceView cDNA sequences:

    CN834310 F08115 CN835866 F06497 NM_002511 AW104598 M73482 F02775 
    AI476439 CN839321 T09210 CN835813 CN832105 R49477 CN839451 Z41733 
    CN834265 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NMBR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCAGGAAA
    NMBR Expression
    About this image


    NMBR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Cerebral Cortex
             Septum   
    NMBR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NMBR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654478

    UniProtKB/Swiss-Prot: NMBR_HUMAN, P28336
    Tissue specificity: Expressed in epididymis (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NMBR: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NMBR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NMBR
    QuantiTect SYBR Green Assays in human, mouse, rat NMBR
    QuantiFast Probe-based Assays in human, mouse, rat NMBR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMBR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NMBR gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nmbr1 , 5 neuromedin B receptor1, 5 86.32(n)1
    90.51(a)1
      10 (5.50 cM)5
    181011  NM_008703.21  NP_032729.11 
     147602895 
    chicken
    (Gallus gallus)
    Aves NMBR1 neuromedin B receptor 73.83(n)
    74.87(a)
      428610  XM_426167.3  XP_426167.1 
    lizard
    (Anolis carolinensis)
    Reptilia NMBR6
    neuromedin B receptor
    66(a)
    1 ↔ 1
    1(203040801-203067610)
    zebrafish
    (Danio rerio)
    Actinopterygii nmbrl1 neuromedin B receptor-like 65.01(n)
    71.07(a)
      561834  XM_685233.3  XP_690325.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG301063
    CCHa1r1
    G-protein coupled receptor protein
    signaling pathway more3
    CCHamide-1 receptor1
    36(a)3
    46.63(n)1
    38.15(a)1
      54D33
    370041  NM_137397.21  NP_611241.21 


    ENSEMBL Gene Tree for NMBR (if available)
    TreeFam Gene Tree for NMBR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NMBR gene
    EDNRA2  GRPR2  GPR372  BRS32  EDNRB2  GPR37L12  
    8 SIMAP similar genes for NMBR using alignment to 2 protein entries:     NMBR_HUMAN (see all proteins):
    GRPR    BRS3    CCR3    GIR    OPRL1    EDNRB
    PRLHR    EDNRA

    NMBR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NMBR (see all 394)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94962541,2
    A--142396246(+) ATATAC/TACACA 1 -- ds50010--------
    rs351343151,2
    C--142396246(+) CACACAC/-TCATG 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1900105681,2
    --142396268(+) TCATGC/TAATAG 1 -- ds50010--------
    rs1808080891,2
    --142396583(+) GATTTA/GAAGTC 1 -- ds50010--------
    rs1181782701,2
    F--142396726(+) TCTGCC/TGAATA 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs2004309571,2
    C--142396748(+) AGTTAC/TTAAGT 1 -- ut310--------
    rs790170771,2
    C--142396758(+) TTCTCG/TCCAGG 1 -- ut310--------
    rs74539441,2,,4
    C,F,A,H--142396790(+) TCACAG/TTGCCA 2 M L mis124Minor allele frequency- T:0.09NS EA NA WA CSA EU 8625
    rs3724645711,2
    C--142396839(+) TTGGTA/CACCAT 2 V syn10--------
    rs1387133961,2
    F--142396854(+) TTAGCA/GTTGCT 2 N syn11Minor allele frequency- G:0.00NA 4550

    HapMap Linkage Disequilibrium report for NMBR (142379467 - 142409936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NMBR:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv7004n71CNV Loss21882294
    nsv886735CNV Loss21882294
    nsv464069CNV Gain19166990
    nsv830824CNV Gain17160897
    dgv7003n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 162341    OMIM disorders: --

    13 diseases for NMBR:    
    About MalaCards
    ovarian epithelial cancer    gastrinoma    epididymitis    pancreatitis
    lung cancer    colon adenocarcinoma    hypoxia    prostate cancer
    adenocarcinoma    obesity    prostatitis    malaria
    cerebritis


    NMBR for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for NMBR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    small cell lung cancer 57.7 3 7832477 (1), 1655761 (1)
    lung carcinoma 43.5 2 1655761 (1)
    carcinoma non-small cell lung 38.6 1 8018339 (1)
    prostate cancer 29.2 1 10679759 (1)
    nsclc 28.7 6 10545285 (2), 8018339 (1), 12569606 (1)
    cancer lung 20.6 2 20388507 (1), 1655761 (1)
    tumors 17.7 12 10828496 (3), 18975117 (1), 15634004 (1), 15528253 (1) (see all 5)
    cancer 15.9 1 15528253 (1)
    adenocarcinoma 2.56 2 11445243 (1)

    Genetic Association Database (GAD): NMBR
    Human Genome Epidemiology (HuGE) Navigator: NMBR (3 documents)

    Export disorders for NMBR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NMBR gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with NMBR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. (PubMed id 1655761)1, 2, 9 Corjay M.H.... Battey J.F. (J. Biol. Chem. 1991)
    2. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (Mol. Cell. Proteomics 2010)
    3. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. (PubMed id 21060863)1, 4 Ikram M.K....Wong T.Y. (PLoS Genet. 2010)
    4. The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding. (PubMed id 8392057)1, 9 Fathi Z....Battey J.F. (J. Biol. Chem. 1993)
    5. Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor. (PubMed id 9632639)1, 9 Sainz E....Battey J.F. (J. Biol. Chem. 1998)
    6. Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. (PubMed id 15528253)1, 9 Matusiak D....Benya R.V. (Am. J. Physiol. Gastrointest. Liver Physiol. 2005)
    7. Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides. (PubMed id 8391296)1, 9 Giladi E....Spindel E.R. (J. Mol. Neurosci. 1993)
    8. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (Mol. Biotechnol. 2008)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Stable association between G alpha(q) and phospholipase C beta 1 in living cells. (PubMed id 16754659)1 Dowal L....Scarlata S. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4829 HGNC: 7843 AceView: NMBR Ensembl:ENSG00000135577 euGenes: HUgn4829
    ECgene: NMBR Kegg: 4829 H-InvDB: NMBR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NMBR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NMBR gene:
    Search GeneIP for patents involving NMBR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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