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NMB Gene

protein-coding   GIFtS: 61
GCID: GC15M085198

Neuromedin B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuromedin B1 2
neuromedin-B2

External Ids:    HGNC: 78421   Entrez Gene: 48282   Ensembl: ENSG000001976967   OMIM: 1623405   UniProtKB: P089493   

Export aliases for NMB gene to outside databases

Previous GC identifers: GC15M081266 GC15P078219 GC15M082785 GC15M082928 GC15M082999 GC15M061284


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NMB Gene:
NMB (neuromedin B) is a protein-coding gene. Diseases associated with NMB include gastrinoma, and late-infantile neuronal ceroid lipofuscinosis. GO annotations related to this gene include hormone activity and neuromedin B receptor binding.

UniProtKB/Swiss-Prot: NMB_HUMAN, P08949
Function: Stimulates smooth muscle contraction in a manner similar to that of bombesin

summary for NMB Gene:
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B
(NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor
(BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The
receptors are Gq/11-coupled and are involved in the regulation of many biological functions including
sensory transmission, thermoregulation, feeding, pituitary, gastric and pancreatic secretion. They may also
be involved in tissue development, proliferation and differentiation.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NMB gene promoter:
         GR   C/EBPbeta   NF-AT2   FOXO4   NF-AT3   GR-alpha   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNMB promoter sequence
   Search Chromatin IP Primers for NMB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NMB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22-qter   Ensembl cytogenetic band:  15q25.3   HGNC cytogenetic band: 15q25.2-q25.3

NMB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMB gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M085198:  view genomic region     (about GC identifiers)

Start:
85,198,360 bp from pter      End:
85,201,802 bp from pter
Size:
3,443 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NMB_HUMAN, P08949 (See protein sequence)
Recommended Name: Neuromedin-B precursor  
Size: 121 amino acids; 13252 Da
2 PDB 3D structures from and Proteopedia for NMB:
1C98 (3D)        1C9A (3D)    
Secondary accessions: Q96A06 Q96HH5
Alternative splicing: 2 isoforms:  P08949-1   P08949-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NMB: NX_P08949

Explore proteomics data for NMB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr52, Ser60, Ser64, Ser65, Ser67, Thr71, Thr75, Ser76
  • Modification sites at PhosphoSitePlus

  • See NMB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_066563.2  NP_995580.1  

    ENSEMBL proteins: 
     ENSP00000353664   ENSP00000378089  
    Reactome Protein details: P08949

    NMB Human Recombinant Protein Products:

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    NMB Assay Products:

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    Cloud-Clone Corp. CLIAs for NMB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000874 Bombesin

    Graphical View of Domain Structure for InterPro Entry P08949

    ProtoNet protein and cluster: P08949

    1 Blocks protein domain: IPB000874 Bombesin-like peptide

    UniProtKB/Swiss-Prot: NMB_HUMAN, P08949
    Similarity: Belongs to the bombesin/neuromedin-B/ranatensin family


    NMB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMB_HUMAN, P08949
    Function: Stimulates smooth muscle contraction in a manner similar to that of bombesin

         Genatlas biochemistry entry for NMB:
    neuromedin B

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity TAS2458345
    GO:0031710neuromedin B receptor binding IEA--
         
    NMB for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NMB
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NMB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NMB

    miRNA
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    Block miRNA regulation of human, mouse, rat NMB using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NMB:
    hsa-miR-1276 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidNMB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NMB
    Predesigned siRNA for gene silencing in human, mouse, rat NMB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NMB

    Clone
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    OriGene clones in human, mouse for NMB (see all 13)
    OriGene ORF clones in mouse, rat for NMB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NMB (NM_004137)
    Sino Biological Human cDNA Clone for NMB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMB

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NMB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NMB_HUMAN, P08949: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0043005neuron projection IEA--

    NMB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NMB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for NMB
        Peptide ligand-binding receptors
    G alpha (q) signalling events



    NMB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NMB: 
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NMB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for NMB (P089492, 3 ENSP000003780894) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NMBRP283363, ENSP000002580424I2D: score=2 STRING: ENSP00000258042
    TPP1O147733, ENSP000002994274I2D: score=2 STRING: ENSP00000299427
    AP2B1P630103I2D: score=1 
    COL11A1ENSP000003511634STRING: ENSP00000351163
    PTPN7ENSP000003562484STRING: ENSP00000356248
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS2458345
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0007267cell-cell signaling TAS2458345
    GO:0008284positive regulation of cell proliferation IEA--

    NMB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NMB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BombesinInvolved in gastrointestinal tract function[31362-50-2]
    PD 176252GRP (BB2) and NMB (BB1) receptor antagonist[204067-01-6]
    GRP (human)Endogenous GRP receptor agonist[93755-85-2]
    GRP (porcine)Endogenous GRP receptor agonist[74815-57-9]
    Neuromedin B (porcine)Mammalian bombesin-like peptide[87096-84-2]

    Selected Novoseek inferred chemical compound relationships for NMB gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phyllolitorin 93.7 14 8786559 (3), 1717141 (1), 19296643 (1), 8788416 (1)
    ranatensin 91.7 9 8786559 (2), 1717141 (1), 8134305 (1), 8788416 (1)
    dtpa 31.6 1 15546210 (1)
    calcium 24.7 20 1328611 (4), 8134305 (3), 8813645 (1), 9220028 (1) (see all 7)
    thapsigargin 13.7 1 8134305 (1)
    opiate 5.36 1 1310640 (1)
    bromodeoxyuridine 4.47 2 10545285 (2)
    hydrogen 0 1 10544247 (1)
    agar 0 2 8532598 (1)
    alanine 0 1 8985785 (1)



    NMB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NMB gene (2 alternative transcripts): 
    NM_021077.3  NM_205858.1  

    Unigene Cluster for NMB:

    Neuromedin B
    Hs.386470  [show with all ESTs]
    Unigene Representative Sequence: NM_021077
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360476 ENST00000394588(uc002bkz.3 uc002bla.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NMB using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NMB:
    hsa-miR-1276 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidNMB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NMB
    Predesigned siRNA for gene silencing in human, mouse, rat NMB
    Clone
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    OriGene clones in human, mouse for NMB (see all 13)
    OriGene ORF clones in mouse, rat for NMB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NMB (NM_004137)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NMB
    OriGene qSTAR qPCR primer pairs in human, mouse for NMB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NMB
      QuantiTect SYBR Green Assays in human, mouse, rat NMB
      QuantiFast Probe-based Assays in human, mouse, rat NMB

    Additional mRNA sequence: 

    AL110112.1 BC007407.2 BC007431.2 BC008603.1 M21551.1 

    1 DOTS entry:

    DT.111368 

    Selected AceView cDNA sequences (see all 595):

    AA026101 AA459913 CR591824 BX110879 BE646080 N85136 BI962836 BF984922 
    AA468797 CD677029 CF529057 BM843667 CR602988 AI265903 AA026643 BU685949 
    BU786014 AA465269 CR596388 W92942 AI625142 BM788956 BM272565 BQ717650 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NMB    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for NMB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NMB expression in normal human tissues (normalized intensities)      NMB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NMB Expression
    About this image


    NMB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Neural Tube (Nervous System)
             Metencephalon
    NMB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NMB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.386470
        Pathway & Disease-focused RT2 Profiler PCR Array including NMB: 
              Obesity in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NMB gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nmb1 , 5 neuromedin B1, 5 82.09(n)1
    73.55(a)1
      7 (45.71 cM)5
    680391  NM_026523.31  NP_080799.11 
     809022275 
    chicken
    (Gallus gallus)
    Aves NMB6
    Gallus gallus neuromedin B (NMB), mRNA.
    33(a)
    1 ↔ 1
    10(520507-523782)
    zebrafish
    (Danio rerio)
    Actinopterygii nmba6
    nmbb6
    neuromedin Bb
    28(a)
    26(a)
    many → 1
    many → 1
    18(26729335-26730228) ENSDARG00000068144
    7(31421782-31423550) ENSDARG00000077167


    ENSEMBL Gene Tree for NMB (if available)
    TreeFam Gene Tree for NMB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NMB (see all 88)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504688411,2
    --85199545(+) GTGCAA/GTAAGG 2 -- int10--------
    rs1178369801,2
    F--85199582(+) AGTTGC/GCACTC 2 -- int11Minor allele frequency- G:0.03NA 120
    rs1426064301,2
    C--85199738(+) TTGAT-/GGGGGG 2 -- int10--------
    rs775236991,2
    C,F--85199921(+) CCAGTC/TCAGGT 2 -- int11Minor allele frequency- T:0.12NA 120
    rs175986031,2
    C,F,H--85200211(+) CCTTTC/GTTTGG 2 -- int1 trp321Minor allele frequency- G:0.15NA NS EA 2162
    rs1383164571,2
    --85200229(+) CTCCTG/TTGAGC 2 -- int10--------
    rs751974141,2
    F--85200237(+) AGCTCT/CGCCTC 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1876366431,2
    --85200282(+) GTCCAC/TACCCA 2 -- int10--------
    rs1927417701,2
    --85200286(+) ACACCC/GATAAT 2 -- int10--------
    rs1430984281,2
    --85200340(+) ATTCCA/TCCCAT 2 -- int10--------

    HapMap Linkage Disequilibrium report for NMB (85198360 - 85201802 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NMB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672879CNV Deletion23128226
    nsv515983CNV Loss19592680
    nsv428310CNV Gain+Loss18775914

    Human Gene Mutation Database (HGMD): NMB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NMB
    DNA2.0 Custom Variant and Variant Library Synthesis for NMB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 162340    OMIM disorders: --

    Selected diseases for NMB (see all 22):    About MalaCards
    gastrinoma    late-infantile neuronal ceroid lipofuscinosis    neuronal ceroid lipofuscinosis    diphtheria
    prader-willi syndrome    lung cancer    pancreatitis    duodenitis
    ulcerative colitis    colon adenocarcinoma    obesity    crohn's disease
    retinitis    ovarian cancer    adenocarcinoma    colorectal cancer
    prostatitis    neuronitis    endotheliitis    prostate cancer


    NMB for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for NMB gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    small cell lung cancer 59.5 3 1671171 (1), 7832477 (1)
    gastrinoma 51.5 4 2101791 (2), 8943970 (1)
    carcinoma non-small cell lung 40.7 3 9279210 (1), 10545285 (1)
    lung carcinoma 34.2 2 8806106 (1)
    nsclc 30.7 16 10545285 (6), 1717141 (3), 9279210 (1)
    lung tumor 26.5 3 1717141 (2)
    cancer lung 24.6 9 1563005 (5), 8959679 (1), 1328611 (1), 20388507 (1)
    tumors 20.6 13 2101791 (3), 11948125 (3), 12365377 (1), 11485826 (1) (see all 7)
    cancer 15.9 3 15528253 (1), 12365378 (1)
    obesity 11.9 5 15585758 (2), 11194934 (1), 20010906 (1)

    Genetic Association Database (GAD): NMB
    Human Genome Epidemiology (HuGE) Navigator: NMB (9 documents)

    Export disorders for NMB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NMB gene, integrated from 10 sources (see all 123):
    (articles sorted by number of sources associating them with NMB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. (PubMed id 2458345)1, 2, 3 Krane I.M.... Spindel E.R. (J. Biol. Chem. 1988)
    2. Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy. (PubMed id 10544247)1, 2, 9 Lee S. and Kim Y. (FEBS Lett. 1999)
    3. Significant association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents. (PubMed id 11194934)1, 4, 9 Oeffner F....Grzeschik K.H. (Acta Diabetol 2000)
    4. Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study. (PubMed id 20010906)1, 4, 9 Pigeyre M....Meirhaeghe A. (Int J Obes (Lond) 2010)
    5. Neuromedin beta: P73T polymorphism in overweight and obese subjects. (PubMed id 18271693)1, 4, 9 SpA!lovA! J....Hainer V. (Physiol Res 2008)
    6. Contribution of several candidate gene polymorphisms in the determination of adiposity changes: results from the QuAcbec Family Study. (PubMed id 17299381)1, 4 Bouchard L....PAcrusse L. (Int J Obes (Lond) 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Expression of neuromedin B in adipose tissue and its regulation by changes in energy balance. (PubMed id 17766645)1, 9 Hoggard N....Speakman J.R. (J. Mol. Endocrinol. 2007)
    9. Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. (PubMed id 15528253)1, 9 Matusiak D....Benya R.V. (Am. J. Physiol. Gastrointest. Liver Physiol. 2005)
    10. Production of neuromedin B and neuromedin B gene expression in human lung tumor cell lines. (PubMed id 1717141)1, 9 Cardona C....Reeve J.G. (Cancer Res. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4828 HGNC: 7842 AceView: SPC18andNMB Ensembl:ENSG00000197696 euGenes: HUgn4828
    ECgene: NMB H-InvDB: NMB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NMB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NMB gene:
    Search GeneIP for patents involving NMB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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