External Ids for NMB Gene
Previous GeneCards Identifiers for NMB Gene
This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
GeneCards Summary for NMB Gene
NMB (Neuromedin B) is a Protein Coding gene. Diseases associated with NMB include Gastrinoma and Neuronal Ceroid Lipofuscinosis. Among its related pathways are Signaling by GPCR and RET signaling. GO annotations related to this gene include hormone activity and neuromedin B receptor binding.
UniProtKB/Swiss-Prot for NMB Gene
Stimulates smooth muscle contraction in a manner similar to that of bombesin.
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).