External Ids for NMB Gene
Previous GeneCards Identifiers for NMB Gene
GeneCards Summary for NMB Gene
NMB (Neuromedin B) is a Protein Coding gene. Diseases associated with NMB include gastrinoma and neuronal ceroid lipofuscinosis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity and neuromedin B receptor binding.
UniProtKB/Swiss-Prot for NMB Gene
Stimulates smooth muscle contraction in a manner similar to that of bombesin
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor (BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The receptors are Gq/11-coupled and are involved in the regulation of many biological functions including sensory transmission, thermoregulation, feeding, pituitary, gastric and pancreatic secretion. They may also be involved in tissue development, proliferation and differentiation.