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Aliases for NMB Gene

Aliases for NMB Gene

  • Neuromedin B 2 3 5
  • Neuromedin-B-32 3
  • Neuromedin-Beta 3

External Ids for NMB Gene

Previous GeneCards Identifiers for NMB Gene

  • GC15M081266
  • GC15P078219
  • GC15M082785
  • GC15M082928
  • GC15M082999
  • GC15M085198
  • GC15M061284

Summaries for NMB Gene

Entrez Gene Summary for NMB Gene

  • This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for NMB Gene

NMB (Neuromedin B) is a Protein Coding gene. Diseases associated with NMB include gastrinoma and late-infantile neuronal ceroid lipofuscinosis. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include hormone activity and neuromedin B receptor binding.

UniProtKB/Swiss-Prot for NMB Gene

  • Stimulates smooth muscle contraction in a manner similar to that of bombesin.

Tocris Summary for NMB Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMB Gene

Genomics for NMB Gene

Regulatory Elements for NMB Gene

Promoters for NMB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NMB on UCSC Golden Path with GeneCards custom track

Genomic Location for NMB Gene

Chromosome:
15
Start:
84,655,129 bp from pter
End:
84,658,571 bp from pter
Size:
3,443 bases
Orientation:
Minus strand

Genomic View for NMB Gene

Genes around NMB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMB Gene

Proteins for NMB Gene

  • Protein details for NMB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08949-NMB_HUMAN
    Recommended name:
    Neuromedin-B
    Protein Accession:
    P08949
    Secondary Accessions:
    • Q96A06
    • Q96HH5

    Protein attributes for NMB Gene

    Size:
    121 amino acids
    Molecular mass:
    13252 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NMB Gene

    Alternative splice isoforms for NMB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NMB Gene

Proteomics data for NMB Gene at MOPED

Post-translational modifications for NMB Gene

  • Glycosylation at Thr 52 and Ser 60
  • Modification sites at PhosphoSitePlus

Other Protein References for NMB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NMB Gene

Domains & Families for NMB Gene

Protein Domains for NMB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NMB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08949

UniProtKB/Swiss-Prot:

NMB_HUMAN :
  • Belongs to the bombesin/neuromedin-B/ranatensin family.
Family:
  • Belongs to the bombesin/neuromedin-B/ranatensin family.
genes like me logo Genes that share domains with NMB: view

No data available for Gene Families for NMB Gene

Function for NMB Gene

Molecular function for NMB Gene

GENATLAS Biochemistry:
neuromedin B
UniProtKB/Swiss-Prot Function:
Stimulates smooth muscle contraction in a manner similar to that of bombesin.

Phenotypes for NMB Gene

genes like me logo Genes that share phenotypes with NMB: view

Animal Model Products

miRNA for NMB Gene

miRTarBase miRNAs that target NMB

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NMB Gene

Localization for NMB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMB Gene COMPARTMENTS Subcellular localization image for NMB gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for NMB Gene

Pathways & Interactions for NMB Gene

genes like me logo Genes that share pathways with NMB: view

SIGNOR curated interactions for NMB Gene

Activates:

Gene Ontology (GO) - Biological Process for NMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0046887 positive regulation of hormone secretion IEA --
GO:0046888 negative regulation of hormone secretion IEA --
genes like me logo Genes that share ontologies with NMB: view

Drugs & Compounds for NMB Gene

(8) Drugs for NMB Gene - From: Novoseek and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bombesin Pharma Full agonist, Agonist Involved in gastrointestinal tract function 7

(9) Additional Compounds for NMB Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BA 1
183241-31-8
BIM 187
137734-88-4
GRP (human)
93755-85-2
GRP (porcine)
74815-57-9
genes like me logo Genes that share compounds with NMB: view

Transcripts for NMB Gene

mRNA/cDNA for NMB Gene

Unigene Clusters for NMB Gene

Neuromedin B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NMB Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for NMB Gene

GeneLoc Exon Structure for
NMB
ECgene alternative splicing isoforms for
NMB

Expression for NMB Gene

mRNA expression in normal human tissues for NMB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMB Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.7).

Protein differential expression in normal tissues from HIPED for NMB Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NMB Gene



SOURCE GeneReport for Unigene cluster for NMB Gene Hs.386470

genes like me logo Genes that share expression patterns with NMB: view

Protein tissue co-expression partners for NMB Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NMB Gene

Orthologs for NMB Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMB 36
  • 92 (a)
OneToOne
NMB 35
  • 98.9 (n)
  • 99.17 (a)
cow
(Bos Taurus)
Mammalia NMB 35
  • 86.23 (n)
  • 78.51 (a)
NMB 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMB 36
  • 66 (a)
OneToOne
NMB 35
  • 84.23 (n)
  • 75.27 (a)
mouse
(Mus musculus)
Mammalia Nmb 35
  • 82.09 (n)
  • 73.55 (a)
Nmb 16
Nmb 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMB 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmb 35
  • 80.87 (n)
  • 73.04 (a)
chicken
(Gallus gallus)
Aves NMB 36
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nmba 36
  • 28 (a)
OneToMany
nmbb 36
  • 26 (a)
OneToMany
Species with no ortholog for NMB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMB Gene

ENSEMBL:
Gene Tree for NMB (if available)
TreeFam:
Gene Tree for NMB (if available)

Paralogs for NMB Gene

No data available for Paralogs for NMB Gene

Variants for NMB Gene

Sequence variations from dbSNP and Humsavar for NMB Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1051168 - 84,657,289(-) CAGCT(A/C)CCCAC reference, missense
rs2175567 -- 84,657,715(+) CCAGC(C/G)GTTAG intron-variant
rs3809509 -- 84,659,837(+) CCCCC(C/T)AATCT upstream-variant-2KB
rs10651266 -- 84,660,510(+) AAAAA(-/G)GGGGG upstream-variant-2KB
rs11637728 -- 84,660,161(+) CCAGA(A/T)GTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NMB Gene

Variant ID Type Subtype PubMed ID
nsv428310 CNV Gain+Loss 18775914
esv2672879 CNV Deletion 23128226
nsv515983 CNV Loss 19592680

Variation tolerance for NMB Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMB Gene

HapMap Linkage Disequilibrium report
NMB
Human Gene Mutation Database (HGMD)
NMB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMB Gene

Disorders for NMB Gene

MalaCards: The human disease database

(6) MalaCards diseases for NMB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastrinoma
  • gastrin cell tumour
late-infantile neuronal ceroid lipofuscinosis
  • jansky-bielschowsky disease
small cell cancer of the lung, somatic
  • lung small cell carcinoma
lung cancer
  • lung cancer, protection against
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards
Search NMB in MalaCards View complete list of genes associated with diseases

Relevant External Links for NMB

Genetic Association Database (GAD)
NMB
Human Genome Epidemiology (HuGE) Navigator
NMB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMB
genes like me logo Genes that share disorders with NMB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMB Gene

Publications for NMB Gene

  1. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. (PMID: 2458345) Krane I.M. … Spindel E.R. (J. Biol. Chem. 1988) 2 3 4 67
  2. Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study. (PMID: 20010906) Pigeyre M. … Meirhaeghe A. (Int J Obes (Lond) 2010) 3 23
  3. Neuromedin beta: P73T polymorphism in overweight and obese subjects. (PMID: 18271693) SpA!lovA! J. … Hainer V. (Physiol Res 2008) 3 23
  4. Expression of neuromedin B in adipose tissue and its regulation by changes in energy balance. (PMID: 17766645) Hoggard N. … Speakman J.R. (J. Mol. Endocrinol. 2007) 3 23
  5. Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. (PMID: 15528253) Matusiak D. … Benya R.V. (Am. J. Physiol. Gastrointest. Liver Physiol. 2005) 3 23

Products for NMB Gene

Sources for NMB Gene

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