Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NMB Gene

protein-coding   GIFtS: 60
GCID: GC15M085198

Neuromedin B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuromedin B1 2
neuromedin-B2

External Ids:    HGNC: 78421   Entrez Gene: 48282   Ensembl: ENSG000001976967   OMIM: 1623405   UniProtKB: P089493   

Export aliases for NMB gene to outside databases

Previous GC identifers: GC15M081266 GC15P078219 GC15M082785 GC15M082928 GC15M082999 GC15M061284


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NMB Gene: 
NMB (neuromedin B) is a protein-coding gene. Diseases associated with NMB include gastrinoma, and neuronal ceroid lipofuscinosis, and among its related super-pathways are Signaling by GPCR and GPCR ligand binding. GO annotations related to this gene include hormone activity and neuromedin B receptor binding.

UniProtKB/Swiss-Prot: NMB_HUMAN, P08949
Function: Stimulates smooth muscle contraction in a manner similar to that of bombesin

summary for NMB Gene:
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B
(NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor
(BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The
receptors are Gq/11-coupled and are involved in the regulation of many biological functions including
sensory transmission, thermoregulation, feeding, pituitary, gastric and pancreatic secretion. They may also
be involved in tissue development, proliferation and differentiation.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010274.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NMB gene promoter:
         GR   C/EBPbeta   NF-AT2   FOXO4   NF-AT3   GR-alpha   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNMB promoter sequence
   Search SABiosciences Chromatin IP Primers for NMB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22-qter   Ensembl cytogenetic band:  15q25.3   HGNC cytogenetic band: 15q25.2-q25.3

NMB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMB gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M085198:  view genomic region     (about GC identifiers)

Start:
85,198,360 bp from pter      End:
85,201,802 bp from pter
Size:
3,443 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NMB_HUMAN, P08949 (See protein sequence)
Recommended Name: Neuromedin-B precursor  
Size: 121 amino acids; 13252 Da
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for NMB:
1C98 (3D)        1C9A (3D)    
Secondary accessions: Q96A06 Q96HH5
Alternative splicing: 2 isoforms:  P08949-1   P08949-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NMB: NX_P08949

Explore proteomics data for NMB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08949

  • NMB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NMB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_066563.2  NP_995580.1  

    ENSEMBL proteins: 
     ENSP00000353664   ENSP00000378089  
    Reactome Protein details: P08949
    Human Recombinant Protein Products for NMB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NMB
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NMB
    GenScript Custom Purified and Recombinant Proteins Services for NMB
    Novus Biologicals NMB Proteins
    Novus Biologicals NMB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NMB 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0043005neuron projection IEA--

    NMB for ontologies           About GeneDecksing



    NMB Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NMB
    GenScript Custom Superior Antibodies Services for NMB
    Abcam antibodies for NMB
    Cloud-Clone Corp. Antibodies for NMB 
    ThermoFisher Antibody for NMB
    LSBio Antibodies in human, mouse, rat for NMB 

    Assay Products for NMB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NMB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NMB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NMB 
    Cloud-Clone Corp. CLIAs for NMB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000874 Bombesin

    Graphical View of Domain Structure for InterPro Entry P08949

    ProtoNet protein and cluster: P08949

    1 Blocks protein domain: IPB000874 Bombesin-like peptide

    UniProtKB/Swiss-Prot: NMB_HUMAN, P08949
    Similarity: Belongs to the bombesin/neuromedin-B/ranatensin family


    NMB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMB_HUMAN, P08949
    Function: Stimulates smooth muscle contraction in a manner similar to that of bombesin

         Genatlas biochemistry entry for NMB:
    neuromedin B

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity TAS2458345
    GO:0031710neuromedin B receptor binding IEA--
         
    NMB for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NMB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NMB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NMB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NMB 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NMB
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NMB:
    hsa-miR-1276 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidNMB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NMB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NMB
    Sirion Biotech Customized adenovirus for overexpression of NMB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NMB (see all 14)
    OriGene ORF clones in mouse, rat for NMB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NMB (NM_004137)
    Sino Biological Human cDNA Clone for NMB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMB
    Sirion Biotech Customized lentivirus for stable overexpression of NMB 
                         Customized lentivirus expression plasmids for stable overexpression of NMB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NMB
    Search LifeMap BioReagents cell lines for NMB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NMB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NMB
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q



    5/8        Reactome Pathways for NMB (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    NMB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NMB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/8 Interacting proteins for NMB (P089492, 3 ENSP000003780894) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NMBRP283363, ENSP000002580424I2D: score=2 STRING: ENSP00000258042
    TPP1O147733, ENSP000002994274I2D: score=2 STRING: ENSP00000299427
    AP2B1P630103I2D: score=1 
    COL11A1ENSP000003511634STRING: ENSP00000351163
    PTPN7ENSP000003562484STRING: ENSP00000356248
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS2458345
    GO:0007204elevation of cytosolic calcium ion concentration IEA--
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0007267cell-cell signaling TAS2458345
    GO:0008284positive regulation of cell proliferation IEA--

    NMB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NMB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NMB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BombesinInvolved in gastrointestinal tract function[31362-50-2]
    PD 176252GRP (BB2) and NMB (BB1) receptor antagonist[204067-01-6]
    GRP (human)Endogenous GRP receptor agonist[93755-85-2]
    GRP (porcine)Endogenous GRP receptor agonist[74815-57-9]
    Neuromedin B (porcine)Mammalian bombesin-like peptide[87096-84-2]

    10/12 Novoseek inferred chemical compound relationships for NMB gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phyllolitorin 93.7 14 8786559 (3), 1717141 (1), 19296643 (1), 8788416 (1)
    ranatensin 91.7 9 8786559 (2), 1717141 (1), 8134305 (1), 8788416 (1)
    dtpa 31.6 1 15546210 (1)
    calcium 24.7 20 1328611 (4), 8134305 (3), 8813645 (1), 9220028 (1) (see all 7)
    thapsigargin 13.7 1 8134305 (1)
    opiate 5.36 1 1310640 (1)
    bromodeoxyuridine 4.47 2 10545285 (2)
    hydrogen 0 1 10544247 (1)
    agar 0 2 8532598 (1)
    alanine 0 1 8985785 (1)

    Search CenterWatch for drugs/clinical trials and news about NMB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NMB gene (2 alternative transcripts): 
    NM_021077.3  NM_205858.1  

    Unigene Cluster for NMB:

    Neuromedin B
    Hs.386470  [show with all ESTs]
    Unigene Representative Sequence: NM_021077
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360476 ENST00000394588(uc002bkz.3 uc002bla.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NMB
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NMB:
    hsa-miR-1276 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidNMB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NMB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMB
    Clone
    Products:
         
    OriGene clones in human, mouse for NMB (see all 14)
    OriGene ORF clones in mouse, rat for NMB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NMB (NM_004137)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMB
    Sirion Biotech Customized lentivirus for stable overexpression of NMB 
                         Customized lentivirus expression plasmids for stable overexpression of NMB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NMB
    OriGene qSTAR qPCR primer pairs in human, mouse for NMB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NMB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMB

    Additional mRNA sequence: 

    AL110112.1 BC007407.2 BC007431.2 BC008603.1 M21551.1 

    1 DOTS entry:

    DT.111368 

    24/595 AceView cDNA sequences (see all 595):

    BI962836 BU615179 BM314085 BM511320 CF455691 CR591824 BM985303 CF529057 
    AI582279 BQ012316 AI335664 CK820834 BE646080 AI004157 BI857321 CA426721 
    CD674097 BM992854 BC014508 BF219735 NM_021077 CR602988 AI538446 BQ431350 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NMB    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for NMB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NMB expression in normal human tissues (normalized intensities)      NMB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NMB Expression
    About this image


    NMB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Peripheral Nervous System (Nervous System)
             dorsal root ganglia   
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Lung (Respiratory System)
             alveolar macrophages   

    See NMB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NMB

    SOURCE GeneReport for Unigene cluster: Hs.386470
        SABiosciences Expression via Pathway-Focused PCR Array including NMB: 
              Obesity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NMB
    OriGene qSTAR qPCR primer pairs in human, mouse for NMB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NMB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NMB gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nmb1 , 5 neuromedin B1, 5 82.09(n)1
    73.55(a)1
      7 (45.71 cM)5
    680391  NM_026523.31  NP_080799.11 
     809022275 
    chicken
    (Gallus gallus)
    Aves NMB6
    neuromedin B precursor
    30(a)
    1 ↔ 1
    10(520507-523782)
    zebrafish
    (Danio rerio)
    Actinopterygii nmba6
    nmbb6
    neuromedin Bb
    31(a)
    25(a)
    many → 1
    many → 1
    18(26729335-26730228)
    7(31421782-31423550)


    ENSEMBL Gene Tree for NMB (if available)
    TreeFam Gene Tree for NMB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/88 SNPs in NMB are shown (see all 88)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504688411,2
    --85199545(+) GTGCAA/GTAAGG 2 -- int10--------
    rs1178369801,2
    F--85199582(+) AGTTGC/GCACTC 2 -- int11Minor allele frequency- G:0.03NA 120
    rs1426064301,2
    C--85199738(+) TTGAT-/GGGGGG 2 -- int10--------
    rs775236991,2
    C,F--85199921(+) CCAGTC/TCAGGT 2 -- int11Minor allele frequency- T:0.12NA 120
    rs175986031,2
    C,F,H--85200211(+) CCTTTC/GTTTGG 2 -- int1 trp321Minor allele frequency- G:0.15NA NS EA 2162
    rs1383164571,2
    --85200229(+) CTCCTG/TTGAGC 2 -- int10--------
    rs751974141,2
    F--85200237(+) AGCTCT/CGCCTC 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1876366431,2
    --85200282(+) GTCCAC/TACCCA 2 -- int10--------
    rs1927417701,2
    --85200286(+) ACACCC/GATAAT 2 -- int10--------
    rs1430984281,2
    --85200340(+) ATTCCA/TCCCAT 2 -- int10--------

    HapMap Linkage Disequilibrium report for NMB (85198360 - 85201802 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NMB:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672879CNV Deletion23128226
    nsv515983CNV Loss19592680
    nsv428310CNV Gain+Loss18775914


    Human Gene Mutation Database (HGMD): NMB
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NMB
    DNA2.0 Custom Variant and Variant Library Synthesis for NMB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 162340    OMIM disorders: --

    20/23 diseases for NMB (see all 23):    About MalaCards
    gastrinoma    neuronal ceroid lipofuscinosis    diphtheria    pancreatitis
    prader-willi syndrome    lung cancer    colon adenocarcinoma    duodenitis
    ulcerative colitis    colon cancer    obesity    crohn's disease
    glioblastoma    gastric cancer    retinitis    adenocarcinoma
    colorectal cancer    ovarian cancer    prostatitis    prostate cancer


    NMB for disorders           About GeneDecksing

    10/13 Novoseek inferred disease relationships for NMB gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    small cell lung cancer 59.5 3 1671171 (1), 7832477 (1)
    gastrinoma 51.5 4 2101791 (2), 8943970 (1)
    carcinoma non-small cell lung 40.7 3 9279210 (1), 10545285 (1)
    lung carcinoma 34.2 2 8806106 (1)
    nsclc 30.7 16 10545285 (6), 1717141 (3), 9279210 (1)
    lung tumor 26.5 3 1717141 (2)
    cancer lung 24.6 9 1563005 (5), 8959679 (1), 1328611 (1), 20388507 (1)
    tumors 20.6 13 2101791 (3), 11948125 (3), 12365377 (1), 11485826 (1) (see all 7)
    cancer 15.9 3 15528253 (1), 12365378 (1)
    obesity 11.9 5 15585758 (2), 11194934 (1), 20010906 (1)

    Genetic Association Database (GAD): NMB
    Human Genome Epidemiology (HuGE) Navigator: NMB (9 documents)

    Export disorders for NMB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NMB gene, integrated from 9 sources (see all 122):
    (articles sorted by number of sources associating them with NMB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. (PubMed id 2458345)1, 2, 3 Krane I.M.... Spindel E.R. (1988)
    2. Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy. (PubMed id 10544247)1, 2, 9 Lee S. and Kim Y. (1999)
    3. Significant association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents. (PubMed id 11194934)1, 4, 9 Oeffner F....Grzeschik K.H. (2000)
    4. Influence of maternal educational level on the associ ation between the rs3809508 neuromedin B gene polymorphism and the risk of obes ity in the HELENA study. (PubMed id 20010906)1, 4, 9 Pigeyre M....Meirhaeghe A. (2010)
    5. Neuromedin beta: P73T polymorphism in overweight and obese subjects. (PubMed id 18271693)1, 4, 9 Spalova J....Hainer V. (2008)
    6. Contribution of several candidate gene polymorphisms in the determination of adiposity changes: results from the Quebec Family Study. (PubMed id 17299381)1, 4 Bouchard L....Perusse L. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Expression of neuromedin B in adipose tissue and its regulation by changes in energy balance. (PubMed id 17766645)1, 9 Hoggard N....Speakman J.R. (2007)
    9. Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. (PubMed id 15528253)1, 9 Matusiak D....Benya R.V. (2005)
    10. Production of neuromedin B and neuromedin B gene expression in human lung tumor cell lines. (PubMed id 1717141)1, 9 Cardona C....Reeve J.G. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4828 HGNC: 7842 AceView: SPC18andNMB Ensembl:ENSG00000197696 euGenes: HUgn4828
    ECgene: NMB H-InvDB: NMB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NMB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NMB gene:
    Search GeneIP for patents involving NMB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NMB  
     OriGene qPCR primer pairs and template standards for NMB   OriGene Protein Over-expression Lysate for NMB  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NMB  
     OriGene qSTAR qPCR primer pairs in human, mouse for NMB   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NMB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NMB   OriGene Custom Protein Services for NMB  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NMB
     QIAGEN SeqTarget long-range PCR primers for resequencing NMB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMB
     GenScript Custom Purified and Recombinant Proteins Services for NMB GenScript cDNA clones with any tag delivered in your preferred vector for NMB
     GenScript Custom Assay Services for NMB GenScript Custom Superior Antibodies Services for NMB
     GenScript Custom overexpressing Cell Line Services for NMB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NMB promoter
     Search Chromatin IP Primers for NMB
     RT2 qPCR Primer Assay in human, mouse, rat NMB
     GNC Network for NMB
     SABiosciences PCR Arrays including human, mouse, rat NMB
     Tocris compounds for NMB
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for NMB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NMB proteins
     NMB lysates
     Antibodies for NMB
     See all of Abcam's Antibodies, Kits and Proteins for NMB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NMB
     Antibodies for NMB
     ELISAs for NMB
     CLIAs for NMB
     Search LifeMap BioReagents cell lines for NMB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMB
     SwitchGear 3'UTR luciferase reporter plasmids for NMB
     SwitchGear Promoter luciferase reporter plasmids for NMB
     ThermoFisher Antibody for NMB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NMB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NMB
    Customized:
     lentivirus for stable overexpression of NMB
     lentivirus expression plasmids for stable overexpression of NMB
     adenovirus for overexpression of NMB
     LSBio Antibodies in human, mouse, rat for NMB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NMB gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4