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Aliases for NMB Gene

Aliases for NMB Gene

  • Neuromedin B 2 3
  • Neuromedin-B 3

External Ids for NMB Gene

Summaries for NMB Gene

GeneCards Summary for NMB Gene

NMB (Neuromedin B) is a Protein Coding gene. Diseases associated with NMB include gastrinoma and lung cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity and neuromedin B receptor binding.

UniProtKB/Swiss-Prot for NMB Gene

  • Stimulates smooth muscle contraction in a manner similar to that of bombesin

Tocris Summary for NMB Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor (BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The receptors are Gq/11-coupled and are involved in the regulation of many biological functions including sensory transmission, thermoregulation, feeding, pituitary, gastric and pancreatic secretion. They may also be involved in tissue development, proliferation and differentiation.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMB Gene

Genomics for NMB Gene

Genomic Location for NMB Gene

Start:
84,655,129 bp from pter
End:
84,658,571 bp from pter
Size:
3,443 bases
Orientation:
Minus strand

Genomic View for NMB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NMB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMB Gene

Regulatory Elements for NMB Gene

Proteins for NMB Gene

  • Protein details for NMB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08949-NMB_HUMAN
    Recommended name:
    Neuromedin-B
    Protein Accession:
    P08949
    Secondary Accessions:
    • Q96A06
    • Q96HH5

    Protein attributes for NMB Gene

    Size:
    121 amino acids
    Molecular mass:
    13252 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NMB Gene

    Alternative splice isoforms for NMB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NMB Gene

Proteomics data for NMB Gene at MOPED

Post-translational modifications for NMB Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr52, Ser60, Ser64, Ser65, Ser67, Thr71, Thr75, and Ser76

Other Protein References for NMB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NMB Gene

Domains for NMB Gene

Protein Domains for NMB Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

NMB_HUMAN
Family:
  • Belongs to the bombesin/neuromedin-B/ranatensin family.:
    • P08949
genes like me logo Genes that share domains with NMB: view

No data available for Gene Families for NMB Gene

Function for NMB Gene

Molecular function for NMB Gene

GENATLAS Biochemistry: neuromedin B
UniProtKB/Swiss-Prot Function: Stimulates smooth muscle contraction in a manner similar to that of bombesin

Gene Ontology (GO) - Molecular Function for NMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 2458345
GO:0005515 protein binding IPI 25416956
GO:0031710 neuromedin B receptor binding IEA --
genes like me logo Genes that share ontologies with NMB: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NMB Gene

Localization for NMB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMB Gene COMPARTMENTS Subcellular localization image for NMB gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with NMB: view

Pathways for NMB Gene

genes like me logo Genes that share pathways with NMB: view

Gene Ontology (GO) - Biological Process for NMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 2458345
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007267 cell-cell signaling TAS 2458345
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with NMB: view

Compounds for NMB Gene

(5) Tocris Compounds for NMB Gene

Compound Action Cas Number
Bombesin Involved in gastrointestinal tract function [31362-50-2]
GRP (human) Endogenous GRP receptor agonist [93755-85-2]
GRP (porcine) Endogenous GRP receptor agonist [74815-57-9]
Neuromedin B (porcine) Mammalian bombesin-like peptide [87096-84-2]
PD 176252 GRP (BB2) and NMB (BB1) receptor antagonist [204067-01-6]

(12) Novoseek inferred chemical compound relationships for NMB Gene

Compound -log(P) Hits PubMed IDs
phyllolitorin 93.7 6
ranatensin 91.7 5
dtpa 31.6 1
calcium 24.7 12
thapsigargin 13.7 1
genes like me logo Genes that share compounds with NMB: view

Transcripts for NMB Gene

mRNA/cDNA for NMB Gene

Unigene Clusters for NMB Gene

Neuromedin B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NMB Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for NMB Gene

GeneLoc Exon Structure for
NMB
ECgene alternative splicing isoforms for
NMB

Expression for NMB Gene

mRNA expression in normal human tissues for NMB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMB Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NMB Gene

SOURCE GeneReport for Unigene cluster for NMB Gene Hs.386470

genes like me logo Genes that share expressions with NMB: view

Orthologs for NMB Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMB 36
  • 98.9 (n)
  • 99.17 (a)
NMB 37
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NMB 36
  • 86.23 (n)
  • 78.51 (a)
NMB 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMB 36
  • 84.23 (n)
  • 75.27 (a)
NMB 37
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmb 36
  • 82.09 (n)
  • 73.55 (a)
Nmb 16
Nmb 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMB 37
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmb 36
  • 80.87 (n)
  • 73.04 (a)
chicken
(Gallus gallus)
Aves NMB 37
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nmba 37
  • 28 (a)
OneToMany
nmbb 37
  • 26 (a)
OneToMany
Species with no ortholog for NMB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMB Gene

ENSEMBL:
Gene Tree for NMB (if available)
TreeFam:
Gene Tree for NMB (if available)

Paralogs for NMB Gene

No data available for Paralogs for NMB Gene

Variants for NMB Gene

Sequence variations from dbSNP and Humsavar for NMB Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs309430 -- 84,659,839(+) CCCCA(A/G)TCTCC upstream-variant-2KB
rs1051168 - 84,657,289(-) CAGCT(A/C)CCCAC missense, reference
rs1849288 -- 84,658,585(+) GGCGA(A/G)GAGCT upstream-variant-2KB
rs2175567 -- 84,657,715(+) CCAGC(C/G)GTTAG intron-variant
rs2292462 -- 84,657,523(+) GCAAA(G/T)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMB Gene

Variant ID Type Subtype PubMed ID
nsv428310 CNV Gain+Loss 18775914
esv2672879 CNV Deletion 23128226
nsv515983 CNV Loss 19592680

Relevant External Links for NMB Gene

HapMap Linkage Disequilibrium report
NMB
Human Gene Mutation Database (HGMD)
NMB

Disorders for NMB Gene

(13) Novoseek inferred disease relationships for NMB Gene

Disease -log(P) Hits PubMed IDs
small cell lung cancer 59.5 2
gastrinoma 51.5 3
carcinoma non-small cell lung 40.7 2
lung carcinoma 34.2 1
nsclc 30.7 10

Relevant External Links for NMB

Genetic Association Database (GAD)
NMB
Human Genome Epidemiology (HuGE) Navigator
NMB
genes like me logo Genes that share disorders with NMB: view

No data available for UniProtKB/Swiss-Prot for NMB Gene

Publications for NMB Gene

  1. Significant association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents. (PMID: 11194934) Oeffner F. … Grzeschik K.H. (Acta Diabetol 2000) 3 23 49
  2. Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy. (PMID: 10544247) Lee S. … Kim Y. (FEBS Lett. 1999) 3 4 23
  3. Neuromedin beta: P73T polymorphism in overweight and obese subjects. (PMID: 18271693) SpA!lovA! J. … Hainer V. (Physiol Res 2008) 3 23 49
  4. Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study. (PMID: 20010906) Pigeyre M. … Meirhaeghe A. (Int J Obes (Lond) 2010) 3 23 49
  5. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. (PMID: 2458345) Krane I.M. … Spindel E.R. (J. Biol. Chem. 1988) 2 3 4

Products for NMB Gene

Sources for NMB Gene

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