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Aliases for NLRX1 Gene

Aliases for NLRX1 Gene

  • NLR Family Member X1 2 3
  • CLR11.3 3 4 6
  • NOD9 3 4 6
  • Nucleotide-Binding Oligomerization Domain Protein 26 3 4
  • Nucleotide-Binding Oligomerization Domain Protein 5 3 4
  • Nucleotide-Binding Oligomerization Domain Protein 9 3 4
  • Caterpiller Protein 11.3 3 4
  • NOD-Like Receptor X1 2 3
  • NOD26 3 4
  • NOD5 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat Containing X1 3
  • Nucleotide-Binding Oligomerization Domain 2
  • Leucine Rich Repeat Containing X1 2
  • NLR Family, X1 3
  • NLR Family 2
  • DLNB26 3
  • X1 2

External Ids for NLRX1 Gene

Summaries for NLRX1 Gene

Entrez Gene Summary for NLRX1 Gene

  • The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for NLRX1 Gene

NLRX1 (NLR Family Member X1) is a Protein Coding gene. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and NF-kappaB Signaling. An important paralog of this gene is NLRP1.

UniProtKB/Swiss-Prot for NLRX1 Gene

  • Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).

Gene Wiki entry for NLRX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRX1 Gene

Genomics for NLRX1 Gene

Genomic Location for NLRX1 Gene

Start:
119,166,568 bp from pter
End:
119,184,016 bp from pter
Size:
17,449 bases
Orientation:
Plus strand

Genomic View for NLRX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLRX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRX1 Gene

Regulatory Elements for NLRX1 Gene

Proteins for NLRX1 Gene

  • Protein details for NLRX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UT6-NLRX1_HUMAN
    Recommended name:
    NLR family member X1
    Protein Accession:
    Q86UT6
    Secondary Accessions:
    • A8K6Q1
    • B3KPK2
    • B3KTA2
    • Q7RTR3
    • Q96D51
    • Q9H724

    Protein attributes for NLRX1 Gene

    Size:
    975 amino acids
    Molecular mass:
    107616 Da
    Quaternary structure:
    • Homohexamer. Interacts with MAVS.
    SequenceCaution:
    • Sequence=BAB15075.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG51714.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG51714.1; Type=Erroneous termination; Positions=951; Note=Translated as Trp.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NLRX1 Gene

    Alternative splice isoforms for NLRX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NLRX1 Gene

Proteomics data for NLRX1 Gene at MOPED

Post-translational modifications for NLRX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NLRX1 Gene

Domains for NLRX1 Gene

Gene Families for NLRX1 Gene

HGNC:
  • NLR :Nucleotide-binding domain and leucine rich repeat containing
IUPHAR :

Protein Domains for NLRX1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NLRX1_HUMAN
Domain:
  • The LRRCT domain mediates homodimerization and LRRNT mediates trimerization of the dimers:
    • Q86UT6
  • Contains 1 LRRCT domain.:
    • Q86UT6
  • Contains 1 LRRNT domain.:
    • Q86UT6
  • Contains 1 NACHT domain.:
    • Q86UT6
Family:
  • Belongs to the NLRP family.:
    • Q86UT6
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.:
    • Q86UT6
genes like me logo Genes that share domains with NLRX1: view

Function for NLRX1 Gene

Molecular function for NLRX1 Gene

UniProtKB/Swiss-Prot Function: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).

Gene Ontology (GO) - Molecular Function for NLRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21903422
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRX1: view
genes like me logo Genes that share phenotypes with NLRX1: view

Animal Models for NLRX1 Gene

MGI Knock Outs for NLRX1:

miRNA for NLRX1 Gene

miRTarBase miRNAs that target NLRX1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NLRX1 Gene

Localization for NLRX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRX1 Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLRX1 Gene COMPARTMENTS Subcellular localization image for NLRX1 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
vacuole 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NLRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane TAS --
genes like me logo Genes that share ontologies with NLRX1: view

Pathways for NLRX1 Gene

genes like me logo Genes that share pathways with NLRX1: view

Pathways by source for NLRX1 Gene

1 R&D Systems pathway for NLRX1 Gene
1 Cell Signaling Technology pathway for NLRX1 Gene

Gene Ontology (GO) - Biological Process for NLRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0032480 negative regulation of type I interferon production TAS --
GO:0032688 negative regulation of interferon-beta production IEA --
GO:0032715 negative regulation of interleukin-6 production IEA --
GO:0039536 negative regulation of RIG-I signaling pathway IEA --
genes like me logo Genes that share ontologies with NLRX1: view

Transcripts for NLRX1 Gene

Unigene Clusters for NLRX1 Gene

NLR family member X1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NLRX1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - -
SP7: -
SP8:
SP9: - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - -
SP13:
SP14:

ExUns: 8h ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14: -

Relevant External Links for NLRX1 Gene

GeneLoc Exon Structure for
NLRX1
ECgene alternative splicing isoforms for
NLRX1

Expression for NLRX1 Gene

mRNA expression in normal human tissues for NLRX1 Gene

mRNA differential expression in normal tissues according to GTEx for NLRX1 Gene

This gene is overexpressed in Esophagus - Mucosa (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NLRX1 Gene

SOURCE GeneReport for Unigene cluster for NLRX1 Gene Hs.524082

mRNA Expression by UniProt/SwissProt for NLRX1 Gene

Q86UT6-NLRX1_HUMAN
Tissue specificity: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level).
genes like me logo Genes that share expressions with NLRX1: view

Orthologs for NLRX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRX1 36
  • 98.87 (n)
  • 99.08 (a)
NLRX1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NLRX1 36
  • 88.25 (n)
  • 91.47 (a)
NLRX1 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NLRX1 36
  • 87.93 (n)
  • 89.85 (a)
NLRX1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nlrx1 36
  • 86.72 (n)
  • 90.25 (a)
Nlrx1 16
Nlrx1 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NLRX1 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NLRX1 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nlrx1 36
  • 86.17 (n)
  • 90.22 (a)
chicken
(Gallus gallus)
Aves LOC419755 36
  • 66.3 (n)
  • 59.83 (a)
NLRX1 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NLRX1 37
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nlrx1 36
  • 58.2 (n)
  • 57.06 (a)
zebrafish
(Danio rerio)
Actinopterygii nlrx1 36
  • 54.26 (n)
  • 47.53 (a)
nlrx1 37
  • 41 (a)
OneToOne
Species with no ortholog for NLRX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NLRX1 Gene

ENSEMBL:
Gene Tree for NLRX1 (if available)
TreeFam:
Gene Tree for NLRX1 (if available)

Paralogs for NLRX1 Gene

Paralogs for NLRX1 Gene

genes like me logo Genes that share paralogs with NLRX1: view

Variants for NLRX1 Gene

Sequence variations from dbSNP and Humsavar for NLRX1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs561830 -- 119,173,036(+) GCAGA(C/T)GGGGC intron-variant
rs626984 -- 119,170,950(-) GTTAA(A/G)CTGGT intron-variant
rs643423 - 119,172,947(-) CCCGG(A/G)TGGGG reference, missense, utr-variant-5-prime
rs644252 -- 119,172,791(-) AGATA(A/C)AGGCC intron-variant
rs654647 -- 119,171,580(-) cggag(C/G)tgaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLRX1 Gene

Variant ID Type Subtype PubMed ID
nsv468879 CNV Loss 19166990

Relevant External Links for NLRX1 Gene

HapMap Linkage Disequilibrium report
NLRX1
Human Gene Mutation Database (HGMD)
NLRX1

Disorders for NLRX1 Gene

Relevant External Links for NLRX1

Genetic Association Database (GAD)
NLRX1
Human Genome Epidemiology (HuGE) Navigator
NLRX1
genes like me logo Genes that share disorders with NLRX1: view

No data available for UniProtKB/Swiss-Prot for NLRX1 Gene

Publications for NLRX1 Gene

  1. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N. … Nunez G. (Nat. Rev. Immunol. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. NLRX1 is a regulator of mitochondrial antiviral immunity. (PMID: 18200010) Moore C.B. … Ting J.P.-Y. (Nature 2008) 3 4
  4. NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. (PMID: 18219313) Tattoli I. … Girardin S.E. (EMBO Rep. 2008) 3 4
  5. Structure and functional characterization of the RNA-binding element of the NLRX1 innate immune modulator. (PMID: 22386589) Hong M. … Wilson I.A. (Immunity 2012) 3 4

Products for NLRX1 Gene

Sources for NLRX1 Gene

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