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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NLRX1 Gene

protein-coding   GIFtS: 59
GCID: GC11P119037

NLR Family Member X1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NLR Family Member X11 2     NOD52 3
CLR11.32 3 5     X11
NOD92 3 5     Leucine Rich Repeat Containing X11
NOD-Like Receptor X11 2     NLR Family1
Caterpiller Protein 11.32 3     Nucleotide-Binding Oligomerization Domain1
Nucleotide-Binding Oligomerization Domain Protein 262 3     DLNB262
Nucleotide-Binding Oligomerization Domain Protein 52 3     NLR Family, X12
Nucleotide-Binding Oligomerization Domain Protein 92 3     Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat Containing
X12
NOD262 3     

External Ids:    HGNC: 298901   Entrez Gene: 796712   Ensembl: ENSG000001607037   OMIM: 6119475   UniProtKB: Q86UT63   

Export aliases for NLRX1 gene to outside databases

Previous GC identifers: GC11P118545 GC11P114978


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NLRX1 Gene:
The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane.
The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the
same protein have been found for this gene. (provided by RefSeq, Aug 2013)

GeneCards Summary for NLRX1 Gene: 
NLRX1 (NLR family member X1) is a protein-coding gene. Diseases associated with NLRX1 include shigellosis, and hepatitis b virus infection, and among its related super-pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Immune System. GO annotations related to this gene include protein binding and ATP binding.

UniProtKB/Swiss-Prot: NLRX1_HUMAN, Q86UT6
Function: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses,
through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no
inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN
N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313)

Gene Wiki entry for NLRX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NLRX1 gene promoter:
         SRF   Oct-B1   oct-B2   Pax-6   SRF (504 AA)   LCR-F1   c-Ets-1   GATA-2   FOXL1   Ik-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLRX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NLRX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLRX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

NLRX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLRX1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P119037:  view genomic region     (about GC identifiers)

Start:
119,037,277 bp from pter      End:
119,054,725 bp from pter
Size:
17,449 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NLRX1_HUMAN, Q86UT6 (See protein sequence)
Recommended Name: NLR family member X1 precursor  
Size: 975 amino acids; 107616 Da
Subunit: Interacts with MAVS
Subcellular location: Mitochondrion outer membrane
Sequence caution: Sequence=BAB15075.1; Type=Erroneous initiation; Sequence=BAG51714.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAG51714.1; Type=Erroneous termination; Positions=951;
Note=Translated as Trp;
1 PDB 3D structure from and Proteopedia for NLRX1:
3UN9 (3D)    
Secondary accessions: A8K6Q1 B3KPK2 B3KTA2 Q7RTR3 Q96D51 Q9H724
Alternative splicing: 2 isoforms:  Q86UT6-1   Q86UT6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NLRX1: NX_Q86UT6

Explore proteomics data for NLRX1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UT6

  • NLRX1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NLRX1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001269072.1  NP_001269073.1  NP_001269287.1  NP_078894.2  NP_733840.1  

    ENSEMBL proteins: 
     ENSP00000400268   ENSP00000402801   ENSP00000402381   ENSP00000386851   ENSP00000292199  
     ENSP00000387334   ENSP00000433442   ENSP00000386858  
    Reactome Protein details: Q86UT6
    Human Recombinant Protein Products for NLRX1: 
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    Cloud-Clone Corp. Proteins for NLRX1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane TAS--

    NLRX1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NLR: Nucleotide-binding domain and leucine rich repeat containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: NLRX1 
    NOD-like receptor family

    1 InterPro protein domain:
     IPR007111 NACHT_NTPase

    Graphical View of Domain Structure for InterPro Entry Q86UT6

    ProtoNet protein and cluster: Q86UT6

    UniProtKB/Swiss-Prot: NLRX1_HUMAN, Q86UT6
    Similarity: Belongs to the NLRP family
    Similarity: Contains 7 LRR (leucine-rich) repeats
    Similarity: Contains 1 NACHT domain


    NLRX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NLRX1_HUMAN, Q86UT6
    Function: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses,
    through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no
    inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN
    N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    NLRX1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NLRX1:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nlrx1):
     growth/size  homeostasis/metabolism  immune system 

    NLRX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nlrx1tm1Jpyt for NLRX1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NLRX1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NLRX1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    Negative regulators of RIG-I/MDA5 signaling0.49
    RIG-I-like receptor signaling pathway0.52
    2Immune System
    Immune System0.56
    Innate Immune System0.50
    3Toll-Like receptor Signaling Pathways
    NOD-like Receptor Signaling Pathways0.59
    4Influenza A
    Influenza A0.34
    5NF-kappaB Signaling
    NF-kappaB Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NLRX1
        NOD-like Receptor Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for NLRX1
        NF-kappaB Signaling

    4        Reactome Pathways for NLRX1
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Negative regulators of RIG-I/MDA5 signaling
    Immune System
    Innate Immune System


    2         Kegg Pathways  (Kegg details for NLRX1):
        RIG-I-like receptor signaling pathway
    Influenza A


    NLRX1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NLRX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/25 Interacting proteins for NLRX1 (Q86UT61, 3 ENSP000002921994) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHUKO151113, ENSP000003594244I2D: score=2 STRING: ENSP00000359424
    FASTKD5Q7L8L63, ENSP000003696184I2D: score=1 STRING: ENSP00000369618
    HAUS6Q7Z4H73, ENSP000003698714I2D: score=1 STRING: ENSP00000369871
    MAVSQ7Z4343, ENSP000004019804I2D: score=1 STRING: ENSP00000401980
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0032480negative regulation of type I interferon production TAS--
    GO:0045087innate immune response TAS--

    NLRX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about NLRX1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NLRX1 gene (5 alternative transcripts): 
    NM_001282143.1  NM_001282144.1  NM_001282358.1  NM_024618.3  NM_170722.1  

    Unigene Cluster for NLRX1:

    NLR family member X1
    Hs.524082  [show with all ESTs]
    Unigene Representative Sequence: BC110890
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482180 ENST00000454811 ENST00000449394 ENST00000422249 ENST00000474751
    ENST00000409991 ENST00000292199(uc001pvu.3 uc001pvw.3) ENST00000481860(uc010rzc.1)
    ENST00000409109(uc001pvx.3) ENST00000468765 ENST00000525863 ENST00000524562
    ENST00000469103 ENST00000409265(uc001pvv.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB094095.1 AK025131.1 AK056454.1 AK095247.1 AK225223.1 AK291716.1 AK303002.1 AL049456.1 
    AY245437.1 BC013199.1 BC023974.2 BC110890.1 BC128205.1 BX647705.1 EF452237.1 

    10 DOTS entries:

    DT.100782647  DT.407521  DT.97788856  DT.120723681  DT.99972735  DT.101976377  DT.100782646  DT.100022882 
    DT.91687673  DT.91969773 

    24/84 AceView cDNA sequences (see all 84):

    AK056454 BE305080 BM720988 NM_024618 AI871860 CD368866 AW474535 AW474509 
    BK001111 BX505411 BX505412 AL039249 AB094095 BE304350 BU624297 BE276372 
    BX647705 BC023974 AI265868 AL049456 NM_170722 BC013199 AW474537 BM015932 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for NLRX1 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ·
    SP1:                                            -     -     -     -     -     -     -     -                                                                     
    SP2:                                      -     -     -     -     -     -     -     -     -                                                                     
    SP3:                                            -     -     -     -     -     -     -     -                                                                     
    SP4:                                                  -     -     -     -     -     -     -                                                                     
    SP5:                                                                          -     -     -                                                                     

    ExUns: 8h ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for NLRX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NLRX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCTTTGC
    NLRX1 Expression
    About this image


    See NLRX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NLRX1

    SOURCE GeneReport for Unigene cluster: Hs.524082

    UniProtKB/Swiss-Prot: NLRX1_HUMAN, Q86UT6
    Tissue specificity: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in
    HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including NLRX1: 
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NLRX1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nlrx11 , 5 NLR family member X11, 5 86.72(n)1
    90.25(a)1
      9 (24.84 cM)5
    2701511  NM_001163742.11  NP_001157214.11 
     442527135 
    chicken
    (Gallus gallus)
    Aves LOC4197551 NLR family member X1-like 66.34(n)
    59.89(a)
      419755  XM_003642592.1  XP_003642640.1 
    lizard
    (Anolis carolinensis)
    Reptilia NLRX16
    NLR family member X1
    53(a)
    1 ↔ 1
    GL343722.1(25162-41749)
    zebrafish
    (Danio rerio)
    Actinopterygii nlrx11 NLR family member X1 54.21(n)
    47.47(a)
      557335  XM_680389.5  XP_685481.4 


    ENSEMBL Gene Tree for NLRX1 (if available)
    TreeFam Gene Tree for NLRX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/494 SNPs in NLRX1 are shown (see all 494)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1994760291,2
    Cuntested1119039151(+) TCTGCC/TTGAAG 2 -- us2k10--------
    rs1994760321,2
    Cuntested1119042066(+) GCAGGA/GCAGAA 2 -- ut510--------
    rs1994760331,2
    Cuntested1119042076(+) AGTCGC/GTCCTA 2 -- ut510--------
    rs1994760341,2
    Cuntested1119042425(+) GGAAGC/GCCGAG 2 -- int10--------
    rs1994760411,2
    Cuntested1119044518(+) TGGGCA/GGCTGC 4 Q R mis10--------
    rs1456443881,2
    C,Funtested1119044712(+) ACTTCC/TGGCTG 4 R W mis12Minor allele frequency- T:0.00NA EU 5871
    rs1994760431,2
    Cuntested1119045226(+) GGGCCA/GCTATG 4 H R mis10--------
    rs1994760461,2
    Cuntested1119045796(+) CGTGCC/TCGCCA 4 P L mis10--------
    rs1994760481,2
    Cuntested1119045968(+) CTGCTC/TTTCAA 4 L syn10--------
    rs1994760531,2
    Cuntested1119053027(+) TGCCCA/GGGAGC 4 Q R mis10--------

    HapMap Linkage Disequilibrium report for NLRX1 (119037277 - 119054725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NLRX1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv468879CNV Loss19166990


    Human Gene Mutation Database (HGMD): NLRX1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NLRX1
    DNA2.0 Custom Variant and Variant Library Synthesis for NLRX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611947    OMIM disorders: --

    5 diseases for NLRX1:    About MalaCards
    shigellosis    hepatitis b virus infection    influenza    hepatitis b
    hepatitis


    NLRX1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NLRX1
    Human Genome Epidemiology (HuGE) Navigator: NLRX1 (4 documents)

    Export disorders for NLRX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NLRX1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with NLRX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NODs: intracellular proteins involved in inflammation and apoptosis. (PubMed id 12766759)1, 2, 3 Inohara N. and Nunez G. (2003)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. (PubMed id 18219313)1, 2 Tattoli I.... Girardin S.E. (2008)
    5. NLRX1 is a regulator of mitochondrial antiviral immunity. (PubMed id 18200010)1, 2 Moore C.B.... Ting J.P.-Y. (2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy. (PubMed id 23321557)1 Lei Y....Ting J.P. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Rare inborn errors associated with chronic hepatitis B virus infection. (PubMed id 22610944)1 Zhao Q....Wang Y. (2012)
    10. The mitochondrial proteins NLRX1 and TUFM form a compl ex that regulates type I interferon and autophagy. (PubMed id 22749352)1 Lei Y....Ting J.P. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79671 HGNC: 29890 AceView: NOD9 Ensembl:ENSG00000160703 euGenes: HUgn79671
    ECgene: NLRX1 Kegg: 79671 H-InvDB: NLRX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NLRX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NLRX1 gene:
    Search GeneIP for patents involving NLRX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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