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NLRX1 Gene

protein-coding   GIFtS: 59
GCID: GC11P119037

NLR Family Member X1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NLR Family Member X11 2     NOD52 3
CLR11.32 3 5     X11
NOD92 3 5     Leucine Rich Repeat Containing X11
NOD-Like Receptor X11 2     NLR Family1
Caterpiller Protein 11.32 3     Nucleotide-Binding Oligomerization Domain1
Nucleotide-Binding Oligomerization Domain Protein 262 3     DLNB262
Nucleotide-Binding Oligomerization Domain Protein 52 3     NLR Family, X12
Nucleotide-Binding Oligomerization Domain Protein 92 3     Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat Containing
X12
NOD262 3     

External Ids:    HGNC: 298901   Entrez Gene: 796712   Ensembl: ENSG000001607037   OMIM: 6119475   UniProtKB: Q86UT63   

Export aliases for NLRX1 gene to outside databases

Previous GC identifers: GC11P118545 GC11P114978


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NLRX1 Gene:
The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane.
The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the
same protein have been found for this gene. (provided by RefSeq, Aug 2013)

GeneCards Summary for NLRX1 Gene:
NLRX1 (NLR family member X1) is a protein-coding gene. An important paralog of this gene is NLRC5.

UniProtKB/Swiss-Prot: NLRX1_HUMAN, Q86UT6
Function: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses,
through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no
inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN
N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313)

Gene Wiki entry for NLRX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NLRX1 gene promoter:
         SRF   Oct-B1   oct-B2   Pax-6   SRF (504 AA)   LCR-F1   c-Ets-1   GATA-2   FOXL1   Ik-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLRX1 promoter sequence
   Search Chromatin IP Primers for NLRX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NLRX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

NLRX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLRX1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P119037:  view genomic region     (about GC identifiers)

Start:
119,037,277 bp from pter      End:
119,054,725 bp from pter
Size:
17,449 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NLRX1_HUMAN, Q86UT6 (See protein sequence)
Recommended Name: NLR family member X1 precursor  
Size: 975 amino acids; 107616 Da
Subunit: Homohexamer. Interacts with MAVS
Sequence caution: Sequence=BAB15075.1; Type=Erroneous initiation; Sequence=BAG51714.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAG51714.1; Type=Erroneous termination; Positions=951;
Note=Translated as Trp;
1 PDB 3D structure from and Proteopedia for NLRX1:
3UN9 (3D)    
Secondary accessions: A8K6Q1 B3KPK2 B3KTA2 Q7RTR3 Q96D51 Q9H724
Alternative splicing: 2 isoforms:  Q86UT6-1   Q86UT6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NLRX1: NX_Q86UT6

Explore proteomics data for NLRX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NLRX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269072.1  NP_001269073.1  NP_001269287.1  NP_078894.2  

    ENSEMBL proteins: 
     ENSP00000400268   ENSP00000402801   ENSP00000402381   ENSP00000386851   ENSP00000292199  
     ENSP00000387334   ENSP00000433442   ENSP00000386858  
    Reactome Protein details: Q86UT6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NLR: Nucleotide-binding domain and leucine rich repeat containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: NLRX1
    NOD-like receptor family

    1 InterPro protein domain:
     IPR007111 NACHT_NTPase

    Graphical View of Domain Structure for InterPro Entry Q86UT6

    ProtoNet protein and cluster: Q86UT6

    UniProtKB/Swiss-Prot: NLRX1_HUMAN, Q86UT6
    Domain: The LRRCT domain mediates homodimerization and LRRNT mediates trimerization of the dimers
    Similarity: Belongs to the NLRP family
    Similarity: Contains 8 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain
    Similarity: Contains 1 NACHT domain


    Find genes that share domains with NLRX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NLRX1_HUMAN, Q86UT6
    Function: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses,
    through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no
    inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN
    N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with NLRX1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NLRX1:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nlrx1):
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with NLRX1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nlrx1tm1Jpyt for NLRX1

       genOway: Develop your customized and physiologically relevant rodent model for NLRX1

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    hsa-miR-424 hsa-miR-15a hsa-miR-497 hsa-miR-195 hsa-miR-16 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidNLRX1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NLRX1_HUMAN, Q86UT6: Mitochondrion outer membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane2
    vacuole2
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane TAS--

    Find genes that share ontologies with NLRX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NLRX1 About    
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    Negative regulators of RIG-I/MDA5 signaling0.42
    RIG-I-like receptor signaling pathway0.47
    2NOD-like Receptor Signaling Pathways
    NOD-like Receptor Signaling Pathways0.58
    3Influenza A
    Influenza A0.34
    4NF-kappaB Signaling
    NF-kappaB Signaling


    Find genes that share SuperPaths with NLRX1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NLRX1
        NOD-like Receptor Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for NLRX1
        NF-kappaB Signaling

    2 Reactome Pathways for NLRX1
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Negative regulators of RIG-I/MDA5 signaling


    2 Kegg Pathways  (Kegg details for NLRX1):
        RIG-I-like receptor signaling pathway
    Influenza A

        Pathway & Disease-focused RT2 Profiler PCR Array including NLRX1: 
              Inflammasomes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NLRX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for NLRX1 (Q86UT61, 3 ENSP000002921994) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHUKO151113, ENSP000003594244I2D: score=2 STRING: ENSP00000359424
    FASTKD5Q7L8L63, ENSP000003696184I2D: score=1 STRING: ENSP00000369618
    HAUS6Q7Z4H73, ENSP000003698714I2D: score=1 STRING: ENSP00000369871
    MAVSQ7Z4343, ENSP000004019804I2D: score=1 STRING: ENSP00000401980
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0032480negative regulation of type I interferon production TAS--
    GO:0032688negative regulation of interferon-beta production IEA--
    GO:0032715negative regulation of interleukin-6 production IEA--

    Find genes that share ontologies with NLRX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NLRX1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NLRX1 gene (5 alternative transcripts): 
    NM_001282143.1  NM_001282144.1  NM_001282358.1  NM_024618.3  NM_170722.1  

    Unigene Cluster for NLRX1:

    NLR family member X1
    Hs.524082  [show with all ESTs]
    Unigene Representative Sequence: BC110890
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482180 ENST00000454811 ENST00000449394 ENST00000422249 ENST00000474751
    ENST00000409991 ENST00000292199(uc001pvu.3 uc001pvw.3) ENST00000481860(uc010rzc.1)
    ENST00000409109(uc001pvx.3) ENST00000468765 ENST00000525863 ENST00000524562
    ENST00000469103 ENST00000409265(uc001pvv.3)
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    Additional mRNA sequence: 

    AB094095.1 AK025131.1 AK056454.1 AK095247.1 AK225223.1 AK291716.1 AK303002.1 AL049456.1 
    AY245437.1 BC013199.1 BC023974.2 BC110890.1 BC128205.1 BX647705.1 EF452237.1 

    10 DOTS entries:

    DT.100782647  DT.407521  DT.97788856  DT.120723681  DT.99972735  DT.101976377  DT.100782646  DT.100022882 
    DT.91687673  DT.91969773 

    Selected AceView cDNA sequences (see all 84):

    AI871860 BE276372 AL049456 BC023974 AW474509 BE305080 BK001111 AL039249 
    AW474535 CD368866 AB094095 BC013199 BE304350 NM_024618 BM720988 BU624297 
    BX505412 AK056454 BX647705 AW474537 NM_170722 AI265868 BX505411 BM686315 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NLRX1 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ·
    SP1:                                            -     -     -     -     -     -     -     -                                                                     
    SP2:                                      -     -     -     -     -     -     -     -     -                                                                     
    SP3:                                            -     -     -     -     -     -     -     -                                                                     
    SP4:                                                  -     -     -     -     -     -     -                                                                     
    SP5:                                                                          -     -     -                                                                     

    ExUns: 8h ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for NLRX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NLRX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCTTTGC
    NLRX1 Expression
    About this image

    NLRX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NLRX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524082

    UniProtKB/Swiss-Prot: NLRX1_HUMAN, Q86UT6
    Tissue specificity: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in
    HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including NLRX1: 
              Inflammasomes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NLRX1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nlrx11 , 5 NLR family member X11, 5 86.72(n)1
    90.25(a)1
      9 (24.84 cM)5
    2701511  NM_178420.31  NP_848507.21 
     442527135 
    chicken
    (Gallus gallus)
    Aves LOC4197551 NLR family member X1-like 66.3(n)
    59.83(a)
      419755  XM_004948038.1  XP_004948095.1 
    lizard
    (Anolis carolinensis)
    Reptilia NLRX16
    NLR family member X1
    54(a)
    1 ↔ 1
    GL343722.1(25162-41749)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nlrx11 NLR family member X1 58.2(n)
    57.06(a)
      100489572  XM_004916051.1  XP_004916108.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nlrx11 NLR family member X1 54.26(n)
    47.53(a)
      557335  XM_005157595.1  XP_005157652.1 


    ENSEMBL Gene Tree for NLRX1 (if available)
    TreeFam Gene Tree for NLRX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NLRX1 gene
    NLRC52  NOD22  NLRP12  CARD82  NOD12  CIITA2  

    Find genes that share paralogs with NLRX1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NLRX1 (see all 494)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1994760291,2
    Cuntested1119039151(+) TCTGCC/TTGAAG 2 -- us2k10--------
    rs1994760321,2
    Cuntested1119042066(+) GCAGGA/GCAGAA 2 -- ut510--------
    rs1994760331,2
    Cuntested1119042076(+) AGTCGC/GTCCTA 2 -- ut510--------
    rs1994760341,2
    Cuntested1119042425(+) GGAAGC/GCCGAG 2 -- int10--------
    rs1994760411,2
    Cuntested1119044518(+) TGGGCA/GGCTGC 4 Q R mis10--------
    rs1456443881,2
    C,Funtested1119044712(+) ACTTCC/TGGCTG 4 R W mis12Minor allele frequency- T:0.00NA EU 5871
    rs1994760431,2
    Cuntested1119045226(+) GGGCCA/GCTATG 4 H R mis10--------
    rs1994760461,2
    Cuntested1119045796(+) CGTGCC/TCGCCA 4 P L mis10--------
    rs1994760481,2
    Cuntested1119045968(+) CTGCTC/TTTCAA 4 L syn10--------
    rs1994760531,2
    Cuntested1119053027(+) TGCCCA/GGGAGC 4 Q R mis10--------

    HapMap Linkage Disequilibrium report for NLRX1 (119037277 - 119054725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NLRX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468879CNV Loss19166990

    Human Gene Mutation Database (HGMD): NLRX1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NLRX1
    DNA2.0 Custom Variant and Variant Library Synthesis for NLRX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611947    OMIM disorders: --


    Find genes that share disorders with NLRX1           About GenesLikeMe

    Genetic Association Database (GAD): NLRX1
    Human Genome Epidemiology (HuGE) Navigator: NLRX1 (4 documents)

    Export disorders for NLRX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NLRX1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with NLRX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NODs: intracellular proteins involved in inflammation and apoptosis. (PubMed id 12766759)1, 2, 3 Inohara N. and Nunez G. (Nat. Rev. Immunol. 2003)
    2. Structure and functional characterization of the RNA-binding element of the NLRX1 innate immune modulator. (PubMed id 22386589)1, 2 Hong M....Wilson I.A. (Immunity 2012)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. (PubMed id 18219313)1, 2 Tattoli I.... Girardin S.E. (EMBO Rep. 2008)
    6. NLRX1 is a regulator of mitochondrial antiviral immunity. (PubMed id 18200010)1, 2 Moore C.B.... Ting J.P.-Y. (Nature 2008)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy. (PubMed id 23321557)1 Lei Y....Ting J.P. (Autophagy 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Rare inborn errors associated with chronic hepatitis B virus infection. (PubMed id 22610944)1 Zhao Q....Wang Y. (Hepatology 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79671 HGNC: 29890 AceView: NOD9 Ensembl:ENSG00000160703 euGenes: HUgn79671
    ECgene: NLRX1 Kegg: 79671 H-InvDB: NLRX1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NLRX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NLRX1 gene:
    Search GeneIP for patents involving NLRX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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