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Aliases for NLRP9 Gene

Aliases for NLRP9 Gene

  • NLR Family, Pyrin Domain Containing 9 2 3 5
  • Nucleotide-Binding Oligomerization Domain Protein 6 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 9 2 3
  • PYRIN And NACHT-Containing Protein 12 3 4
  • NALP9 3 4
  • PAN12 3 4
  • NOD6 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 9 3
  • Leucine Rich Repeat And Pyrin Domain Containing 9 2
  • Nucleotide-Binding Oligomerization Domain 2
  • NACHT, LRR And PYD Containing Protein 9 3
  • CLR19.1 3

External Ids for NLRP9 Gene

Previous HGNC Symbols for NLRP9 Gene

  • NALP9

Previous GeneCards Identifiers for NLRP9 Gene

  • GC19M060912
  • GC19M056219
  • GC19M052531

Summaries for NLRP9 Gene

Entrez Gene Summary for NLRP9 Gene

  • The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]

GeneCards Summary for NLRP9 Gene

NLRP9 (NLR Family, Pyrin Domain Containing 9) is a Protein Coding gene. An important paralog of this gene is NLRP7.

UniProtKB/Swiss-Prot for NLRP9 Gene

  • Involved in inflammation.

Gene Wiki entry for NLRP9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP9 Gene

Genomics for NLRP9 Gene

Regulatory Elements for NLRP9 Gene

Enhancers for NLRP9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NLRP9 on UCSC Golden Path with GeneCards custom track

Genomic Location for NLRP9 Gene

55,708,432 bp from pter
55,745,528 bp from pter
37,097 bases
Minus strand

Genomic View for NLRP9 Gene

Genes around NLRP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP9 Gene

Proteins for NLRP9 Gene

  • Protein details for NLRP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 9
    Protein Accession:
    Secondary Accessions:
    • B2RN12
    • Q86W27

    Protein attributes for NLRP9 Gene

    991 amino acids
    Molecular mass:
    113312 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NLRP9 Gene


neXtProt entry for NLRP9 Gene

Proteomics data for NLRP9 Gene at MOPED

Post-translational modifications for NLRP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NLRP9

No data available for DME Specific Peptides for NLRP9 Gene

Domains & Families for NLRP9 Gene

Gene Families for NLRP9 Gene

Protein Domains for NLRP9 Gene

Suggested Antigen Peptide Sequences for NLRP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 NACHT domain.
  • Belongs to the NLRP family.
  • Contains 6 LRR (leucine-rich) repeats.
  • Contains 1 NACHT domain.
  • Contains 1 pyrin domain.
  • Belongs to the NLRP family.
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRP9: view

Function for NLRP9 Gene

Molecular function for NLRP9 Gene

UniProtKB/Swiss-Prot Function:
Involved in inflammation.

Phenotypes for NLRP9 Gene

genes like me logo Genes that share phenotypes with NLRP9: view

Animal Model Products

CRISPR Products

miRNA for NLRP9 Gene

miRTarBase miRNAs that target NLRP9

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLRP9 Gene

Localization for NLRP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRP9 Gene


Subcellular locations from

Jensen Localization Image for NLRP9 Gene COMPARTMENTS Subcellular localization image for NLRP9 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NLRP9 Gene

Pathways & Interactions for NLRP9 Gene

SuperPathways for NLRP9 Gene

No Data Available

Interacting Proteins for NLRP9 Gene

Gene Ontology (GO) - Biological Process for NLRP9 Gene


No data available for Pathways by source and SIGNOR curated interactions for NLRP9 Gene

Drugs & Compounds for NLRP9 Gene

No Compound Related Data Available

Transcripts for NLRP9 Gene

mRNA/cDNA for NLRP9 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NLRP9 Gene

NLR family, pyrin domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP9 Gene

No ASD Table

Relevant External Links for NLRP9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLRP9 Gene

mRNA expression in normal human tissues for NLRP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NLRP9 Gene

This gene is overexpressed in Breast (66.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NLRP9 Gene

SOURCE GeneReport for Unigene cluster for NLRP9 Gene Hs.661568

genes like me logo Genes that share expression patterns with NLRP9: view

Protein tissue co-expression partners for NLRP9 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NLRP9 Gene

Orthologs for NLRP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NLRP9 35
  • 72.01 (n)
  • 60.04 (a)
NLRP9 36
  • 60 (a)
(Canis familiaris)
Mammalia NLRP9 35
  • 77.24 (n)
  • 68.19 (a)
NLRP9 36
  • 61 (a)
(Mus musculus)
Mammalia Nlrp9b 35
  • 61.65 (n)
  • 46.57 (a)
Nlrp9b 16
Nlrp9a 36
  • 45 (a)
Nlrp9b 36
  • 45 (a)
Nlrp9c 36
  • 45 (a)
(Pan troglodytes)
Mammalia NLRP9 35
  • 96.61 (n)
  • 95.93 (a)
NLRP9 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nlrp9 35
  • 62.78 (n)
  • 48.16 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
Species with no ortholog for NLRP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP9 Gene

Gene Tree for NLRP9 (if available)
Gene Tree for NLRP9 (if available)

Paralogs for NLRP9 Gene

(10) SIMAP similar genes for NLRP9 Gene using alignment to 1 proteins: Pseudogenes for NLRP9 Gene

genes like me logo Genes that share paralogs with NLRP9: view

Variants for NLRP9 Gene

Sequence variations from dbSNP and Humsavar for NLRP9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_036386 A breast cancer sample
rs7256523 -- 55,735,738(+) GCTAA(A/C)GTGCA intron-variant
rs7256736 -- 55,707,969(+) TGTGG(A/G)AAAAG downstream-variant-500B
rs7259060 -- 55,739,924(+) ACAGA(A/G)AAGTA intron-variant, upstream-variant-2KB
rs7259346 -- 55,740,136(+) CAAAC(A/G)CAATA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NLRP9 Gene

Variant ID Type Subtype PubMed ID
nsv833882 CNV Loss 17160897
nsv2554 CNV Insertion 18451855
nsv510927 CNV Complex 20534489
nsv912505 CNV Gain 21882294
esv27102 CNV Gain 19812545
esv1008459 CNV Insertion 20482838
nsv912506 CNV Gain 21882294
dgv1132e1 CNV Complex 17122850
nsv9771 CNV Loss 18304495

Variation tolerance for NLRP9 Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NLRP9 Gene

Disorders for NLRP9 Gene

Relevant External Links for NLRP9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NLRP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP9 Gene

Publications for NLRP9 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PMID: 23377640) (Am J Psychiatry 2013) 3
  4. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings J.R. … Jewell D.P. (Tissue Antigens 2010) 3
  5. Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos. (PMID: 16339045) Ponsuksili S. … Schwerin M. (Biol. Reprod. 2006) 23

Products for NLRP9 Gene

Sources for NLRP9 Gene