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Aliases for NLRP9 Gene

Aliases for NLRP9 Gene

  • NLR Family Pyrin Domain Containing 9 2 3 5
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 9 2 3
  • Nucleotide-Binding Oligomerization Domain Protein 6 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 9 2 3
  • PYRIN And NACHT-Containing Protein 12 3 4
  • NALP9 3 4
  • PAN12 3 4
  • NOD6 3 4
  • NACHT, LRR And PYD Domains-Containing Protein 9 3
  • NACHT, LRR And PYD Containing Protein 9 3
  • CLR19.1 3

External Ids for NLRP9 Gene

Previous HGNC Symbols for NLRP9 Gene

  • NALP9

Previous GeneCards Identifiers for NLRP9 Gene

  • GC19M060912
  • GC19M056219
  • GC19M052531

Summaries for NLRP9 Gene

Entrez Gene Summary for NLRP9 Gene

  • The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]

GeneCards Summary for NLRP9 Gene

NLRP9 (NLR Family Pyrin Domain Containing 9) is a Protein Coding gene. An important paralog of this gene is NLRP4.

UniProtKB/Swiss-Prot for NLRP9 Gene

  • Involved in inflammation.

Gene Wiki entry for NLRP9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP9 Gene

Genomics for NLRP9 Gene

Regulatory Elements for NLRP9 Gene

Enhancers for NLRP9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G055466 0.7 FANTOM5 2.9 +279.1 279146 0.3 BCOR HDGF SMARCE1 ZMYM3 ZNF311 ZBTB7A ZNF48 FOSL1 ARID1B ZNF121 SBK3 NLRP11 NLRP8 NLRP9 ENSG00000283567 ENSG00000279063
GH19G055707 0.4 FANTOM5 3.1 +38.3 38287 0.1 CHD7 NLRP9 U2AF2 KMT5C GC19P055709 ENSG00000267689
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NLRP9 on UCSC Golden Path with GeneCards custom track

Genomic Location for NLRP9 Gene

Chromosome:
19
Start:
55,708,432 bp from pter
End:
55,745,528 bp from pter
Size:
37,097 bases
Orientation:
Minus strand

Genomic View for NLRP9 Gene

Genes around NLRP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP9 Gene

Proteins for NLRP9 Gene

  • Protein details for NLRP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTR0-NALP9_HUMAN
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 9
    Protein Accession:
    Q7RTR0
    Secondary Accessions:
    • B2RN12
    • Q86W27

    Protein attributes for NLRP9 Gene

    Size:
    991 amino acids
    Molecular mass:
    113312 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NLRP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NLRP9 Gene

Post-translational modifications for NLRP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP9 Gene

No data available for DME Specific Peptides for NLRP9 Gene

Domains & Families for NLRP9 Gene

Gene Families for NLRP9 Gene

Suggested Antigen Peptide Sequences for NLRP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTR0

UniProtKB/Swiss-Prot:

NALP9_HUMAN :
  • Belongs to the NLRP family.
Family:
  • Belongs to the NLRP family.
genes like me logo Genes that share domains with NLRP9: view

Function for NLRP9 Gene

Molecular function for NLRP9 Gene

UniProtKB/Swiss-Prot Function:
Involved in inflammation.

Gene Ontology (GO) - Molecular Function for NLRP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRP9: view
genes like me logo Genes that share phenotypes with NLRP9: view

Animal Models for NLRP9 Gene

MGI Knock Outs for NLRP9:

Animal Model Products

CRISPR Products

miRNA for NLRP9 Gene

miRTarBase miRNAs that target NLRP9

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NLRP9 Gene

Localization for NLRP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRP9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NLRP9 gene
Compartment Confidence
cytosol 3
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NLRP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NLRP9: view

Pathways & Interactions for NLRP9 Gene

SuperPathways for NLRP9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NLRP9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NLRP9 Gene

Drugs & Compounds for NLRP9 Gene

No Compound Related Data Available

Transcripts for NLRP9 Gene

mRNA/cDNA for NLRP9 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NLRP9 Gene

NLR family, pyrin domain containing 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP9 Gene

No ASD Table

Relevant External Links for NLRP9 Gene

GeneLoc Exon Structure for
NLRP9
ECgene alternative splicing isoforms for
NLRP9

Expression for NLRP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NLRP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NLRP9 Gene

This gene is overexpressed in Breast (66.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NLRP9 Gene



Protein tissue co-expression partners for NLRP9 Gene

NURSA nuclear receptor signaling pathways regulating expression of NLRP9 Gene:

NLRP9

SOURCE GeneReport for Unigene cluster for NLRP9 Gene:

Hs.661568
genes like me logo Genes that share expression patterns with NLRP9: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLRP9 Gene

Orthologs for NLRP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRP9 34 35
  • 96.61 (n)
dog
(Canis familiaris)
Mammalia NLRP9 34 35
  • 77.24 (n)
cow
(Bos Taurus)
Mammalia NLRP9 34 35
  • 72.01 (n)
rat
(Rattus norvegicus)
Mammalia Nlrp9 34
  • 62.78 (n)
mouse
(Mus musculus)
Mammalia Nlrp9b 34 16 35
  • 61.65 (n)
Nlrp9a 35
  • 45 (a)
OneToMany
Nlrp9c 35
  • 45 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 29 (a)
OneToMany
Species where no ortholog for NLRP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP9 Gene

ENSEMBL:
Gene Tree for NLRP9 (if available)
TreeFam:
Gene Tree for NLRP9 (if available)

Paralogs for NLRP9 Gene

(10) SIMAP similar genes for NLRP9 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NLRP9 Gene

genes like me logo Genes that share paralogs with NLRP9: view

Variants for NLRP9 Gene

Sequence variations from dbSNP and Humsavar for NLRP9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_036386 A breast cancer sample
rs199475846 untested 55,738,355(-) TTTTT(C/T)GGATT reference, missense
rs199475847 untested 55,732,809(-) GTGCT(A/G/T)GTTGG reference, missense
rs199475848 untested 55,732,775(-) CTAGA(C/G)AGGGG reference, missense
rs199475849 untested 55,732,613(-) ACATA(C/T)ACATT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NLRP9 Gene

Variant ID Type Subtype PubMed ID
esv1008459 CNV insertion 20482838
esv27102 CNV gain 19812545
esv2758773 CNV gain 17122850
esv3331669 CNV duplication 20981092
esv3401861 CNV duplication 20981092
esv3583576 CNV loss 25503493
esv3644844 CNV loss 21293372
esv3644845 CNV loss 21293372
nsv1057383 CNV gain 25217958
nsv1058739 CNV loss 25217958
nsv1060269 CNV gain 25217958
nsv2554 CNV insertion 18451855
nsv510927 OTHER complex 20534489
nsv580344 CNV gain 21841781
nsv580345 CNV loss 21841781
nsv580346 CNV gain 21841781
nsv833882 CNV loss 17160897
nsv9771 CNV loss 18304495

Variation tolerance for NLRP9 Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NLRP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NLRP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP9 Gene

Disorders for NLRP9 Gene

Relevant External Links for NLRP9

Genetic Association Database (GAD)
NLRP9
Human Genome Epidemiology (HuGE) Navigator
NLRP9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NLRP9

No disorders were found for NLRP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP9 Gene

Publications for NLRP9 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4 64
  2. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings J.R. … Jewell D.P. (Tissue Antigens 2010) 3 46 64
  3. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N. … Nunez G. (Nat. Rev. Immunol. 2003) 3 4 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PMID: 23377640) (Am J Psychiatry 2013) 3 64

Products for NLRP9 Gene

Sources for NLRP9 Gene

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