NLRP8 Gene
protein-coding GIFtS: 46
GCID: GC19P056460
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NLR family, pyrin domain containing 8(Previous names: NACHT, leucine rich repeat and PYD containing 8 )
(Previous symbol: NALP8)
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Aliases
for NLRP8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NLR Family, Pyrin Domain Containing 81 2 | | Nucleotide-Binding Oligomerization Domain Protein 162 3 | | NALP81 2 3 5 | | PYRIN And NACHT-Containing Protein 42 3 | | NOD161 2 3 5 | | NACHT, LRR And PYD Containing Protein 82 | | PAN41 2 3 5 | | NACHT, LRR And PYD Domains-Containing Protein 82 | | CLR19.21 2 | | Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin DomainContaining 82 | | NACHT, Leucine Rich Repeat And PYD Containing 81 2 | | |
Export aliases for NLRP8 gene to outside databasesPrevious GC identifers: GC19P061152 GC19P052769 |
Summaries
for NLRP8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NLRP8:
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs,such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, aNACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636),also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD).NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement inmultiprotein complexes called inflammasomes (Tschopp et al., 2003 (PubMed 12563287)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: NALP8_HUMAN, Q86W28Function: Involved in inflammation (Potential)
Gene Wiki entry for NLRP8
|
Genomic Views
for NLRP8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NLRP8
Other transcription factors
Search SABiosciences Chromatin IP Primers for NLRP8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLRP8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43NLRP8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P056460: view genomic region
(about GC identifiers)
Start:
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56,459,198 bp from pter |
End:
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56,499,995 bp from pter |
Size:
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40,798 bases |
Orientation:
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plus strand |
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Proteins
for NLRP8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NALP8_HUMAN, Q86W28 (See
protein sequence)Recommended Name: NACHT, LRR and PYD domains-containing protein 8 Size: 1048 amino acids; 119430 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q7RTR4Alternative splicing: 2 isoforms: Q86W28-1 Q86W28-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NLRP8: NX_Q86W28
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86W28
NLRP8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_789781.2
ENSEMBL proteins: ENSP00000291971 ENSP00000468121
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
NLRP8 for ontologies About GeneDecksing
NLRP8 Antibody Products:
Assay Products for NLRP8: |
Protein
Domains /
Families
for NLRP8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NLRP8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86W28ProtoNet protein and cluster: Q86W28 2 Blocks protein families: IPB001611 Leucine-rich repeat signature IPB004020 Pyrin domain
UniProtKB/Swiss-Prot: NALP8_HUMAN, Q86W28Similarity: Belongs to the NLRP familySimilarity: Contains 1 DAPIN domainSimilarity: Contains 5 LRR (leucine-rich) repeatsSimilarity: Contains 1 NACHT domain |
Function
for NLRP8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NALP8_HUMAN, Q86W28Function: Involved in inflammation (Potential)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLRP8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRP8 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- |
NLRP8 for ontologies About GeneDecksing
|
Pathways & Interactions
for NLRP8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NLRP8
|
Drugs & Compounds
for NLRP8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NLRP8
Search CenterWatch for drugs/clinical trials and news about NLRP8 / NALP8
|
Transcripts
for NLRP8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NLRP8 gene: NM_176811.2 Unigene Cluster for NLRP8: NLR family, pyrin domain containing 8 Hs.446925 Unigene Representative Sequence: NM_1768112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000291971(uc002qmh.3 uc010etg.3) ENST00000590542
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLRP8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLRP8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NLRP8 (NM_176811) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NLRP8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLRP8 |
Additional cDNA sequence: AY154463.1 3 AceView cDNA sequences: AY154463 BK001109 NM_176811
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for NLRP8 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for NLRP8
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Expression
for NLRP8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NLRP8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCCGCAAAA
About this image
See NLRP8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NLRP8
SOURCE GeneReport for Unigene cluster: Hs.446925
SABiosciences Custom PCR Arrays for NLRP8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLRP8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NLRP8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLRP8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLRP8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRP8 |
Orthologs
for NLRP8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NLRP8 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for NLRP8 (if available)
TreeFam Gene Tree for NLRP8 (if available) |
Paralogs
for NLRP8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NLRP8 gene
- NLRP132 NLRP42 NLRP92 NLRP62 NLRP32 NLRP142 NLRP72 NLRP112
- NLRP102 NLRP22 NLRP52 NLRP12 NLRP122
9 SIMAP similar genes for NLRP8 using alignment to 1 protein entry: NALP8_HUMAN:NLRP14 NLRP5 NLRP7 NLRP9 NLRP2 NLRP4
NLRP13 NLRP3 NLRP12
NLRP8 for paralogs About GeneDecksing
|
Genomic Variants
for NLRP8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NLRP8 (56459198 - 56499995 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for NLRP8
13 CNVs: 78288 89329 89330 89335 78285 78284 89331 89334 78283 78286 89332 78287 89336 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLRP8 |
|
Disorders
/ Diseases
for NLRP8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NLRP8 for disorders About GeneDecksing
OMIM gene information: 609659
OMIM disorders: --
4  diseases for NLRP8: About MalaCardschronic lymphocytic leukemia lymphocytic leukemia crohn's disease leukemia
Human Genome Epidemiology (HuGE) Navigator: NLRP8 (3 documents)
Export disorders for NLRP8 gene to outside databases
|
Publications
for NLRP8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NLRP8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NLRP8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- NALPs: a novel protein family involved in inflammation. (PubMed id 12563287)1, 2, 3 Tschopp J....Burns K. (2003)
- NODs: intracellular proteins involved in inflammation and apoptosis. (PubMed id 12766759)1, 2 Inohara N. and Nunez G. (2003)
- Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The genetics of NOD-like receptors in Crohn's disease . (PubMed id 20403135)1 Cummings J.R....Jewell D.P. (2010)
- Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1 Enjuanes A....Campo E. (2008)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos. (PubMed id 16339045)9 Ponsuksili S....Schwerin M. (2006)
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External Searches for NLRP8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NLRP8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NLRP8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NLRP8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NLRP8 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for NLRP8 gene:
Search GeneIP for patents involving NLRP8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NLRP8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | NLRP8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRP8 |
|  |  |  | | | | ThermoFisher Antibodies for NLRP8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLRP8 |
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