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Aliases for NLRP8 Gene

Aliases for NLRP8 Gene

  • NLR Family, Pyrin Domain Containing 8 2 3
  • NALP8 3 4 6
  • NOD16 3 4 6
  • PAN4 3 4 6
  • Nucleotide-Binding Oligomerization Domain Protein 16 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 8 2 3
  • PYRIN And NACHT-Containing Protein 4 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 8 3
  • Leucine Rich Repeat And Pyrin Domain Containing 8 2
  • NACHT, LRR And PYD Domains-Containing Protein 8 3
  • Nucleotide-Binding Oligomerization Domain 2
  • NACHT, LRR And PYD Containing Protein 8 3
  • CLR19.2 3

External Ids for NLRP8 Gene

Previous HGNC Symbols for NLRP8 Gene

  • NALP8

Previous GeneCards Identifiers for NLRP8 Gene

  • GC19P061152
  • GC19P056460
  • GC19P052769

Summaries for NLRP8 Gene

Entrez Gene Summary for NLRP8 Gene

  • NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NLRP8 Gene

NLRP8 (NLR Family, Pyrin Domain Containing 8) is a Protein Coding gene. An important paralog of this gene is NLRC3.

UniProtKB/Swiss-Prot for NLRP8 Gene

  • Involved in inflammation.

Gene Wiki entry for NLRP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP8 Gene

Genomics for NLRP8 Gene

Genomic Location for NLRP8 Gene

55,947,832 bp from pter
55,988,629 bp from pter
40,798 bases
Plus strand

Genomic View for NLRP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLRP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP8 Gene

No data available for Regulatory Elements for NLRP8 Gene

Proteins for NLRP8 Gene

  • Protein details for NLRP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q7RTR4

    Protein attributes for NLRP8 Gene

    1048 amino acids
    Molecular mass:
    119430 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NLRP8 Gene


neXtProt entry for NLRP8 Gene

Proteomics data for NLRP8 Gene at MOPED

Post-translational modifications for NLRP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NLRP8 Gene

Domains for NLRP8 Gene

Gene Families for NLRP8 Gene

  • NLR :Nucleotide-binding domain and leucine rich repeat containing

Protein Domains for NLRP8 Gene

Suggested Antigen Peptide Sequences for NLRP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86W28
  • Contains 1 DAPIN domain.
  • Contains 1 NACHT domain.
  • Belongs to the NLRP family.
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRP8: view

Function for NLRP8 Gene

Molecular function for NLRP8 Gene

UniProtKB/Swiss-Prot Function:
Involved in inflammation.

Gene Ontology (GO) - Molecular Function for NLRP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRP8: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NLRP8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NLRP8 Gene

Localization for NLRP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRP8 Gene


Subcellular locations from

Jensen Localization Image for NLRP8 Gene COMPARTMENTS Subcellular localization image for NLRP8 gene
Compartment Confidence
cytosol 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for NLRP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NLRP8: view

Pathways for NLRP8 Gene

SuperPathways for NLRP8 Gene

No Data Available

Interacting Proteins for NLRP8 Gene

Gene Ontology (GO) - Biological Process for NLRP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070997 neuron death IMP 22166940
genes like me logo Genes that share ontologies with NLRP8: view

No data available for Pathways by source for NLRP8 Gene

Transcripts for NLRP8 Gene

mRNA/cDNA for NLRP8 Gene

(2) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NLRP8

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP2: -

Relevant External Links for NLRP8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLRP8 Gene

mRNA expression in normal human tissues for NLRP8 Gene

mRNA differential expression in normal tissues according to GTEx for NLRP8 Gene

This gene is overexpressed in Testis (18.1), Breast - Mammary Tissue (14.4), and Prostate (12.1).

Protein differential expression in normal tissues for NLRP8 Gene

This gene is overexpressed in Pancreatic juice (44.1) and Tonsil (19.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NLRP8 Gene

SOURCE GeneReport for Unigene cluster for NLRP8 Gene Hs.446925

genes like me logo Genes that share expressions with NLRP8: view

Expression partners for NLRP8 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NLRP8 Gene

Orthologs for NLRP8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NLRP8 35
  • 64.55 (n)
  • 53.23 (a)
NLRP8 36
  • 53 (a)
(Canis familiaris)
Mammalia NLRP8 35
  • 73.52 (n)
  • 62.02 (a)
NLRP8 36
  • 60 (a)
(Pan troglodytes)
Mammalia NLRP8 35
  • 99.01 (n)
  • 98.47 (a)
NLRP8 36
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
Species with no ortholog for NLRP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP8 Gene

Gene Tree for NLRP8 (if available)
Gene Tree for NLRP8 (if available)

Paralogs for NLRP8 Gene

Selected SIMAP similar genes for NLRP8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NLRP8: view

Variants for NLRP8 Gene

Sequence variations from dbSNP and Humsavar for NLRP8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs167388 -- 55,950,276(-) acgcc(C/T)ggcta intron-variant
rs172588 -- 55,972,239(-) tactc(A/G)gaagg intron-variant
rs182520 -- 55,970,389(-) GCTCA(G/T)GAACT intron-variant
rs306453 -- 55,989,038(-) TTCTA(C/T)ACATT downstream-variant-500B
rs306454 -- 55,988,725(-) CCGCT(C/G)TACAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NLRP8 Gene

Variant ID Type Subtype PubMed ID
nsv912507 CNV Gain 21882294
nsv912510 CNV Gain 21882294
esv2719001 CNV Deletion 23290073
esv2669780 CNV Deletion 23128226
esv2719002 CNV Deletion 23290073

Relevant External Links for NLRP8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP8 Gene

Disorders for NLRP8 Gene

Relevant External Links for NLRP8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for NLRP8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NLRP8 Gene

Publications for NLRP8 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4
  2. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N. … Nunez G. (Nat. Rev. Immunol. 2003) 3 4
  3. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PMID: 19074885) Enjuanes A. … Campo E. (Cancer Res. 2008) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings J.R. … Jewell D.P. (Tissue Antigens 2010) 3 48

Products for NLRP8 Gene

Sources for NLRP8 Gene

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