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Aliases for NLRP8 Gene

Aliases for NLRP8 Gene

  • NLR Family, Pyrin Domain Containing 8 2 3 5
  • Nucleotide-Binding Oligomerization Domain Protein 16 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 8 2 3
  • PYRIN And NACHT-Containing Protein 4 3 4
  • NALP8 3 4
  • NOD16 3 4
  • PAN4 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 8 3
  • Leucine Rich Repeat And Pyrin Domain Containing 8 2
  • Nucleotide-Binding Oligomerization Domain 2
  • NACHT, LRR And PYD Containing Protein 8 3
  • CLR19.2 3

External Ids for NLRP8 Gene

Previous HGNC Symbols for NLRP8 Gene

  • NALP8

Previous GeneCards Identifiers for NLRP8 Gene

  • GC19P061152
  • GC19P056460
  • GC19P052769

Summaries for NLRP8 Gene

Entrez Gene Summary for NLRP8 Gene

  • NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NLRP8 Gene

NLRP8 (NLR Family, Pyrin Domain Containing 8) is a Protein Coding gene. An important paralog of this gene is NLRP7.

UniProtKB/Swiss-Prot for NLRP8 Gene

  • Involved in inflammation.

Gene Wiki entry for NLRP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP8 Gene

Genomics for NLRP8 Gene

Regulatory Elements for NLRP8 Gene

Enhancers for NLRP8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NLRP8 on UCSC Golden Path with GeneCards custom track

Genomic Location for NLRP8 Gene

Chromosome:
19
Start:
55,947,832 bp from pter
End:
55,988,629 bp from pter
Size:
40,798 bases
Orientation:
Plus strand

Genomic View for NLRP8 Gene

Genes around NLRP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP8 Gene

Proteins for NLRP8 Gene

  • Protein details for NLRP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W28-NALP8_HUMAN
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 8
    Protein Accession:
    Q86W28
    Secondary Accessions:
    • Q7RTR4

    Protein attributes for NLRP8 Gene

    Size:
    1048 amino acids
    Molecular mass:
    119430 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NLRP8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NLRP8 Gene

Proteomics data for NLRP8 Gene at MOPED

Post-translational modifications for NLRP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NLRP8

No data available for DME Specific Peptides for NLRP8 Gene

Domains & Families for NLRP8 Gene

Gene Families for NLRP8 Gene

Protein Domains for NLRP8 Gene

Suggested Antigen Peptide Sequences for NLRP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W28

UniProtKB/Swiss-Prot:

NALP8_HUMAN :
  • Contains 1 NACHT domain.
  • Belongs to the NLRP family.
  • Contains 5 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 NACHT domain.
  • Contains 1 pyrin domain.
Family:
  • Belongs to the NLRP family.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRP8: view

Function for NLRP8 Gene

Molecular function for NLRP8 Gene

UniProtKB/Swiss-Prot Function:
Involved in inflammation.

Gene Ontology (GO) - Molecular Function for NLRP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRP8: view

Phenotypes for NLRP8 Gene

GenomeRNAi human phenotypes for NLRP8:
genes like me logo Genes that share phenotypes with NLRP8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLRP8 Gene

Localization for NLRP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRP8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLRP8 Gene COMPARTMENTS Subcellular localization image for NLRP8 gene
Compartment Confidence
cytosol 3
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for NLRP8 Gene

Pathways & Interactions for NLRP8 Gene

SuperPathways for NLRP8 Gene

No Data Available

Interacting Proteins for NLRP8 Gene

Gene Ontology (GO) - Biological Process for NLRP8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NLRP8 Gene

Drugs & Compounds for NLRP8 Gene

No Compound Related Data Available

Transcripts for NLRP8 Gene

mRNA/cDNA for NLRP8 Gene

(3) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2: -

Relevant External Links for NLRP8 Gene

GeneLoc Exon Structure for
NLRP8
ECgene alternative splicing isoforms for
NLRP8

Expression for NLRP8 Gene

mRNA expression in normal human tissues for NLRP8 Gene

mRNA differential expression in normal tissues according to GTEx for NLRP8 Gene

This gene is overexpressed in Testis (x18.1), Breast - Mammary Tissue (x14.4), and Prostate (x12.1).

Protein differential expression in normal tissues from HIPED for NLRP8 Gene

This gene is overexpressed in Pancreatic juice (44.1) and Tonsil (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NLRP8 Gene



SOURCE GeneReport for Unigene cluster for NLRP8 Gene Hs.446925

genes like me logo Genes that share expression patterns with NLRP8: view

Protein tissue co-expression partners for NLRP8 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NLRP8 Gene

Orthologs for NLRP8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NLRP8 35
  • 64.55 (n)
  • 53.23 (a)
NLRP8 36
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NLRP8 35
  • 73.52 (n)
  • 62.02 (a)
NLRP8 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NLRP8 35
  • 99.01 (n)
  • 98.47 (a)
NLRP8 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
OneToMany
Species with no ortholog for NLRP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP8 Gene

ENSEMBL:
Gene Tree for NLRP8 (if available)
TreeFam:
Gene Tree for NLRP8 (if available)

Paralogs for NLRP8 Gene

(8) SIMAP similar genes for NLRP8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NLRP8: view

Variants for NLRP8 Gene

Sequence variations from dbSNP and Humsavar for NLRP8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs306507 - 55,947,976(+) TATTC(C/T)GCCCT reference, missense
rs306506 - 55,948,248(-) GACTA(C/G)AACAC reference, missense
rs11880691 - 55,954,758(+) TCTAC(A/G)CCCAC reference, missense
rs7259764 - 55,954,861(+) ATCTC(A/G)GGACC reference, missense
rs11880748 - 55,955,157(+) ATTTC(C/G/T)AGATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NLRP8 Gene

Variant ID Type Subtype PubMed ID
nsv912507 CNV Gain 21882294
nsv912510 CNV Gain 21882294
esv2719001 CNV Deletion 23290073
esv2669780 CNV Deletion 23128226
esv2719002 CNV Deletion 23290073

Variation tolerance for NLRP8 Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.89; 74.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NLRP8 Gene

Disorders for NLRP8 Gene

Relevant External Links for NLRP8

Genetic Association Database (GAD)
NLRP8
Human Genome Epidemiology (HuGE) Navigator
NLRP8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NLRP8

No disorders were found for NLRP8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP8 Gene

Publications for NLRP8 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4 67
  2. A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease. (PMID: 22166940) Rovelet-Lecrux A. … Campion D. (Eur. J. Hum. Genet. 2012) 3
  3. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for NLRP8 Gene

Sources for NLRP8 Gene

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