Aliases for NLRP8 Gene
External Ids for NLRP8 Gene
Previous HGNC Symbols for NLRP8 Gene
Previous GeneCards Identifiers for NLRP8 Gene
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
GeneCards Summary for NLRP8 Gene
NLRP8 (NLR Family, Pyrin Domain Containing 8) is a Protein Coding gene. An important paralog of this gene is NLRP7.
UniProtKB/Swiss-Prot for NLRP8 Gene
Involved in inflammation.