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NLRP7 Gene

protein-coding   GIFtS: 61
GCID: GC19M055434

NLR Family, Pyrin Domain Containing 7

(Previous names: NACHT, leucine rich repeat and PYD containing 7)
(Previous symbol: NALP7)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NLR Family, Pyrin Domain Containing 71 2     Leucine Rich Repeat And Pyrin Domain Containing 71
NALP71 2 3 5     Nucleotide-Binding Oligomerization Domain1
NOD122 3 5     CLR19.42
PYPAF32 3 5     PAN72
NACHT, Leucine Rich Repeat And PYD Containing 71 2     NACHT, LRR And PYD Containing Protein 72
Nucleotide-Binding Oligomerization Domain Protein 122 3     NACHT, LRR And PYD Domains-Containing Protein 72
PYRIN-Containing APAF1-Like Protein 32 3     Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin
Domain Containing 72
HYDM2 5     

External Ids:    HGNC: 229471   Entrez Gene: 1997132   Ensembl: ENSG000001676347   OMIM: 6096615   UniProtKB: Q8WX943   

Export aliases for NLRP7 gene to outside databases

Previous GC identifers: GC19M060127 GC19M051757


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NLRP7 Gene:
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an
N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal
leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases
through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of
caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants
encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for NLRP7 Gene:
NLRP7 (NLR family, pyrin domain containing 7) is a protein-coding gene. Diseases associated with NLRP7 include gestational trophoblastic neoplasm, and hydatidiform mole, recurrent. An important paralog of this gene is NLRP4.

UniProtKB/Swiss-Prot: NALP7_HUMAN, Q8WX94
Function: Inhibits CASP1/caspase-1-dependent IL1B secretion

Gene Wiki entry for NLRP7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NT_187693.1  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NLRP7 gene promoter:
         AP-1   ATF-2   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLRP7 promoter sequence
   Search Chromatin IP Primers for NLRP7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NLRP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

NLRP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLRP7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055434:  view genomic region     (about GC identifiers)

Start:
55,434,877 bp from pter      End:
55,477,680 bp from pter
Size:
42,804 bases      Orientation:
minus strand

Selected alternative locations (see all 8):
Chr19-,NW_003571054 826,907-850,903      Chr19-,NW_003571059 841,873-865,869      Chr19-,NW_003571055 568,711-592,706     
Chr19-,NW_003571056 903,494-927,490      Chr19-,NW_003571058 905,580-929,576      Chr19-,NW_003571057 931,031-955,027     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NALP7_HUMAN, Q8WX94 (See protein sequence)
Recommended Name: NACHT, LRR and PYD domains-containing protein 7  
Size: 980 amino acids; 111807 Da
Subunit: Directly interacts with CASP1 and IL1B
1 PDB 3D structure from and Proteopedia for NLRP7:
2KM6 (3D)    
Secondary accessions: E9PE16 Q32MH8 Q7RTR1
Alternative splicing: 3 isoforms:  Q8WX94-1   Q8WX94-2   Q8WX94-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NLRP7: NX_Q8WX94

Explore proteomics data for NLRP7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NLRP7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001120727.1  NP_631915.2  NP_996611.2  

    ENSEMBL proteins: 
     ENSP00000329568   ENSP00000465520   ENSP00000467123   ENSP00000468243   ENSP00000468706  
     ENSP00000468161   ENSP00000467234   ENSP00000467589   ENSP00000414273   ENSP00000409137  
     ENSP00000339491  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NLR: Nucleotide-binding domain and leucine rich repeat containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: NLRP7
    NOD-like receptor family

    4 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR007111 NACHT_NTPase
     IPR027417 P-loop_NTPase
     IPR004020 DAPIN

    Graphical View of Domain Structure for InterPro Entry Q8WX94

    ProtoNet protein and cluster: Q8WX94

    1 Blocks protein domain: IPB004020 Pyrin domain

    UniProtKB/Swiss-Prot: NALP7_HUMAN, Q8WX94
    Similarity: Belongs to the NLRP family
    Similarity: Contains 1 DAPIN domain
    Similarity: Contains 9 LRR (leucine-rich) repeats
    Similarity: Contains 1 NACHT domain


    NLRP7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NALP7_HUMAN, Q8WX94
    Function: Inhibits CASP1/caspase-1-dependent IL1B secretion
    Induction: By bacterial lipopolysaccharides (LPS) and IL1B/interleukin-1 beta in peripheral blood mononuclear
    cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
         
    NLRP7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NLRP7:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NLRP7
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    hsa-mir-335-5p (MIRT018316)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    mitochondrion1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NLRP7 About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    NOD-like Receptor Signaling Pathways0.58
    2Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD pathway0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NLRP7
        NOD-like Receptor Signaling Pathways


    1 BioSystems Pathway for NLRP7
        NOD pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NLRP7
    Interactions:

        Search GeneGlobe Interaction Network for NLRP7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for NLRP7 (Q8WX943 ENSP000003295684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP1P294663I2D: score=1 
    FAF1Q9UNN53I2D: score=1 
    IL1BP015843I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response ----

    NLRP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NLRP7 (NALP7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NLRP7 gene (3 alternative transcripts): 
    NM_001127255.1  NM_139176.3  NM_206828.3  

    Unigene Cluster for NLRP7:

    NLR family, pyrin domain containing 7
    Hs.351118  [show with all ESTs]
    Unigene Representative Sequence: AK302655
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328092(uc002qii.4 uc010esk.3) ENST00000590030 ENST00000588756
    ENST00000586379 ENST00000592784 ENST00000587844 ENST00000587103 ENST00000590659
    ENST00000446217(uc010esl.3) ENST00000448121(uc002qig.4) ENST00000340844(uc002qih.4)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF464765.1 AK298630.1 AK302655.1 AK313964.1 AY154462.1 BC109124.2 BC109125.1 

    5 DOTS entries:

    DT.91723045  DT.100686115  DT.91716314  DT.97838651  DT.95285740 

    Selected AceView cDNA sequences (see all 42):

    NM_206828 CR607466 BX356996 CR594199 BQ642431 BQ061119 BQ066740 AY154462 
    BK001113 AI360576 BI828545 BQ059434 BQ065843 BQ058731 NM_139176 AF464765 
    AA991648 BQ058852 CD051200 BX646340 BQ642323 AA558585 BQ065714 BX363945 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NLRP7 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:                                                                                                      
    SP2:                                                                          -                           
    SP3:                                      -                                                               
    SP4:                                                                          -     -                     
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for NLRP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NLRP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGCTATGTA
    NLRP7 Expression
    About this image

    NLRP7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NLRP7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.351118

    UniProtKB/Swiss-Prot: NALP7_HUMAN, Q8WX94
    Tissue specificity: Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain.
    Not detected in skeletal muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NLRP7 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    29(a)
    1 → many
    GL343482.1(99797-117577)
            Species with no ortholog for NLRP7

    ENSEMBL Gene Tree for NLRP7 (if available)
    TreeFam Gene Tree for NLRP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NLRP7 gene
    NLRP42  NLRP132  NLRP92  NLRC32  NLRP62  NLRP32  NLRP142  NLRP112  
    NLRP102  NLRP22  NLRP52  NLRP82  NLRP122  
    13 SIMAP similar genes for NLRP7 using alignment to 7 protein entries:     NALP7_HUMAN (see all proteins):
    PYDC2    NLRP2    PP1579    CIAS1    RNH1    NLRP14
    NLRP8    NLRP4    NLRP9    NLRP3    NLRP5    NLRP12
    NLRP13

    NLRP7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NLRP7
    PGOHUM00000241546


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NLRP7 (see all 997)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048955031,2,,4
    C,FHydatidiform mole, recurrent, 1 (HYDM1)4 pathogenic155593570(-) TATCAA/GCCAGA 6 N S mis11Minor allele frequency- G:0.00NA 4550
    VAR_0267114
    Hydatidiform mole, recurrent, 1 (HYDM1)4--see VAR_0267112 R P mis40--------
    VAR_0267124
    Hydatidiform mole, recurrent, 1 (HYDM1)4--see VAR_0267122 R W mis40--------
    VAR_0590404
    Hydatidiform mole, recurrent, 1 (HYDM1)4--see VAR_0590402 C Y mis40--------
    VAR_0590384
    Hydatidiform mole, recurrent, 1 (HYDM1)4--see VAR_0590382 P A mis40--------
    VAR_0590374
    Hydatidiform mole, recurrent, 1 (HYDM1)4--see VAR_0590372 R Q mis40--------
    VAR_0590394
    Hydatidiform mole, recurrent, 1 (HYDM1)4--see VAR_0590392 R W mis40--------
    VAR_0590364
    Hydatidiform mole, recurrent, 1 (HYDM1)4--see VAR_0590362 P S mis40--------
    VAR_0590354
    Hydatidiform mole, recurrent, 1 (HYDM1)4--see VAR_0590352 L R mis40--------
    rs1048955021,2
    Cpathogenic155601096(-) TGTGCA/C/GGATTC 9 Q P R mis10--------

    HapMap Linkage Disequilibrium report for NLRP7 (55434877 - 55477680 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for NLRP7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667609CNV Deletion23128226
    esv2718872CNV Deletion23290073
    nsv520644CNV Loss19592680
    nsv833880CNV Loss17160897
    nsv9766CNV Loss18304495
    nsv912444CNV Gain21882294
    nsv428372CNV Gain+Loss18775914
    dgv1126e1CNV Complex17122850
    dgv1127e1CNV Complex17122850
    dgv1119e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): NLRP7
    Locus Specific Mutation Databases (LSDB): NLRP7

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NLRP7
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609661   
    OMIM disorders: 231090  
    UniProtKB/Swiss-Prot: NALP7_HUMAN, Q8WX94
  • Hydatidiform mole, recurrent, 1 (HYDM1) [MIM:231090]: A disorder characterized by excessive trophoblast
    development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to
    abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 11 diseases for NLRP7:    
    About MalaCards
    gestational trophoblastic neoplasm    hydatidiform mole, recurrent    partial hydatidiform mole    trophoblastic neoplasm
    seminoma    pregnancy loss    choriocarcinoma    crohn's disease
    inflammatory bowel disease    multiple myeloma    myeloma

    1 disease from the University of Copenhagen DISEASES database for NLRP7:
    Gestational trophoblastic neoplasm

    NLRP7 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for NLRP7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    seminoma 74.2 3 15596043 (3)
    carcinoma embryonal 68.1 2 15994931 (1), 15596043 (1)
    tumors 4.65 2 15596043 (1)

    Genetic Association Database (GAD): NLRP7
    Human Genome Epidemiology (HuGE) Navigator: NLRP7 (2 documents)

    Export disorders for NLRP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NLRP7 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with NLRP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NALPs: a novel protein family involved in inflammation. (PubMed id 12563287)1, 2, 3 Tschopp J.... Burns K. (Nat. Rev. Mol. Cell Biol. 2003)
    2. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. (PubMed id 12019269)1, 2, 3 Wang L.... Bertin J. (J. Biol. Chem. 2002)
    3. PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion. (PubMed id 15817483)1, 2, 9 Kinoshita T.... Suda T. (J. Biol. Chem. 2005)
    4. The genetics of NOD-like receptors in Crohn's disease. (PubMed id 20403135)1, 4 Cummings J.R....Jewell D.P. (Tissue Antigens 2010)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. Identification of 13 novel NLRP7 mutations in 20 families with recurrent hydatidiform mole; missense mutations cluster in the leucine-rich region. (PubMed id 19246479)1, 2 Wang C.M.... Fisher R.A. (J. Med. Genet. 2009)
    7. Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. (PubMed id 16462743)1, 2 Murdoch S....Slim R. (Nat. Genet. 2006)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    9. NODs: intracellular proteins involved in inflammation and apoptosis. (PubMed id 12766759)1, 2 Inohara N. and Nunez G. (Nat. Rev. Immunol. 2003)
    10. Oncogenic role of NALP7 in testicular seminomas. (PubMed id 15596043)1, 9 Okada K....Katagiri T. (Cancer Sci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 199713 HGNC: 22947 AceView: NALP7 Ensembl:ENSG00000167634 euGenes: HUgn199713
    ECgene: NLRP7 H-InvDB: NLRP7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NLRP7 Pharmacogenomics, SNPs, Pathways
    INFEVERShttp://fmf.igh.cnrs.fr/ISSAID/infevers/search.php?n=8

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NLRP7 gene:
    Search GeneIP for patents involving NLRP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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