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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NLRP5 Gene

protein-coding   GIFtS: 54
GCID: GC19P056511

NLR Family, Pyrin Domain Containing 5

(Previous names: NACHT, leucine rich repeat and PYD containing 5)
(Previous symbol: NALP5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NLR Family, Pyrin Domain Containing 51 2     CLR19.82
NALP51 2 3 5     PAN112
MATER2 3 5     PYPAF82
NACHT, Leucine Rich Repeat And PYD Containing 51 2     Maternal Antigen That Embryos Require2
Mater Protein Homolog2 3     NACHT, LRR And PYD Domains-Containing Protein 52
Leucine Rich Repeat And Pyrin Domain Containing 51     Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin
Domain Containing 52
Nucleotide-Binding Oligomerization Domain1     

External Ids:    HGNC: 212691   Entrez Gene: 1262062   Ensembl: ENSG000001714877   OMIM: 6096585   UniProtKB: P590473   

Export aliases for NLRP5 gene to outside databases

Previous GC identifers: GC19P061203 GC19P052821


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NLRP5 Gene:
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically
contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an
N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a
maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. (provided
by RefSeq, Jul 2008)

GeneCards Summary for NLRP5 Gene: 
NLRP5 (NLR family, pyrin domain containing 5) is a protein-coding gene. Diseases associated with NLRP5 include autoimmune polyendocrine syndrome type 1, and oophoritis. GO annotations related to this gene include ATP binding. An important paralog of this gene is NLRP4.

UniProtKB/Swiss-Prot: NALP5_HUMAN, P59047
Function: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress
beyond the first embryonic cell divisions (By similarity)

Gene Wiki entry for NLRP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NLRP5 gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLRP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for NLRP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLRP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

NLRP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLRP5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P056511:  view genomic region     (about GC identifiers)

Start:
56,511,092 bp from pter      End:
56,573,179 bp from pter
Size:
62,088 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NALP5_HUMAN, P59047 (See protein sequence)
Recommended Name: NACHT, LRR and PYD domains-containing protein 5  
Size: 1200 amino acids; 134342 Da
Subunit: Component of the SCMC which also includes at least OOEP and TLE6 (By similarity)
Subcellular location: Mitochondrion (By similarity). Nucleus, nucleolus (By similarity). Cytoplasm (By
similarity). Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From
the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity)
Secondary accessions: A8MTY4 Q86W29

Explore the universe of human proteins at neXtProt for NLRP5: NX_P59047

Explore proteomics data for NLRP5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P59047

  • NLRP5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NLRP5 Protein Expression
    REFSEQ proteins: NP_703148.4  
    ENSEMBL proteins: 
     ENSP00000375063   ENSP00000471494  

    Human Recombinant Protein Products for NLRP5: 
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    Cloud-Clone Corp. Proteins for NLRP5 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus ISS--
    GO:0005739mitochondrion ISS--
    GO:0005829cytosol IEA--
    GO:0005938cell cortex ----
    GO:0043234protein complex IEA--

    NLRP5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NLR: Nucleotide-binding domain and leucine rich repeat containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: NLRP5 
    NOD-like receptor family

    4 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR007111 NACHT_NTPase
     IPR027417 P-loop_NTPase
     IPR004020 DAPIN

    Graphical View of Domain Structure for InterPro Entry P59047

    ProtoNet protein and cluster: P59047

    2 Blocks protein domains:
    IPB003590 Leucine-rich repeat
    IPB004020 Pyrin domain


    UniProtKB/Swiss-Prot: NALP5_HUMAN, P59047
    Similarity: Belongs to the NLRP family
    Similarity: Contains 1 DAPIN domain
    Similarity: Contains 13 LRR (leucine-rich) repeats
    Similarity: Contains 1 NACHT domain


    NLRP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NALP5_HUMAN, P59047
    Function: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress
    beyond the first embryonic cell divisions (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    NLRP5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NLRP5:
     Decreased viability after Chla  Increased cell number in G1, a 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nlrp5):
     embryogenesis  other  reproductive system 

    NLRP5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nlrp5tm1Zbt for NLRP5

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NLRP5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for NLRP5 (P590473 ENSP000003750634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OOEPA6NGQ23, ENSP000003593844STRING: ENSP00000359384 I2D: score=3 
    TLE6Q9H8083I2D: score=3 
    KHDC3LQ587J83I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0007566embryo implantation IEA--
    GO:0009566fertilization IEA--
    GO:0009887organ morphogenesis IEA--
    GO:0031647regulation of protein stability IEA--

    NLRP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NLRP5 (NALP5)

    Search CenterWatch for drugs/clinical trials and news about NLRP5 / NALP5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for NLRP5 gene: 
    NM_153447.4  

    Unigene Cluster for NLRP5:

    NLR family, pyrin domain containing 5
    Hs.356872  [show with all ESTs]
    Unigene Representative Sequence: AY154460
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000390649(uc002qmj.3 uc002qmi.3) ENST00000597673
    miRNA
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    Additional mRNA sequence: 

    AY054986.1 AY154460.1 

    1 DOTS entry:

    DT.100010128 

    7 AceView cDNA sequences:

    AY154460 BU634350 NM_153447 BU630481 AY054986 CK000513 BU618831 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NLRP5 expression in normal human tissues (normalized intensities)      NLRP5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGACTGACT
    NLRP5 Expression
    About this image


    NLRP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Secondary Oocyte Antral Follicle
             Secondary follicles
             ovary ; follicle cells   
             oocyte   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             testis ; cells in seminiferus ducts   

    See NLRP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NLRP5

    SOURCE GeneReport for Unigene cluster: Hs.356872

    UniProtKB/Swiss-Prot: NALP5_HUMAN, P59047
    Tissue specificity: Oocyte-specific

        SABiosciences Expression via Pathway-Focused PCR Array including NLRP5: 
              Inflammasomes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for NLRP5 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nlrp51 , 5 NLR family, pyrin domain containing 51, 5 65.97(n)1
    53.31(a)1
      7 (10.22 cM)5
    239681  NM_011860.21  NP_035990.11 
     233858895 


    ENSEMBL Gene Tree for NLRP5 (if available)
    TreeFam Gene Tree for NLRP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NLRP5 gene
    NLRP42  NLRP132  NLRP92  NLRC32  NLRP62  NLRP32  NLRP142  NLRP72  
    NLRP112  NLRP102  NLRP22  NLRP82  NLRP122  
    11 SIMAP similar genes for NLRP5 using alignment to 2 protein entries:     NALP5_HUMAN (see all proteins):
    CIAS1    NLRP14    PYDC2    NLRP8    RNH1    NLRP13
    NLRP12    NLRP2    NLRP4    NLRP7    NLRP3

    NLRP5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2655 SNPs in NLRP5 are shown (see all 2655)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1994757591,2
    Cuntested156510842(+) AGTAGC/TGTCGT 1 -- us2k10--------
    rs1994757631,2
    Cuntested156511154(+) CGTGCA/GTCGAC 1 -- spd10--------
    rs1994757681,2
    Cuntested156531030(+) CACAAA/CTTTGT 1 -- int10--------
    rs1994762251,2
    Cuntested156532110(+) ATGCTG/TTCTTC 1 -- int10--------
    rs1994757721,2
    Cuntested156538389(+) AAATGC/GAAACG 2 Q E mis10--------
    rs1994757731,2
    Cuntested156538671(+) GGCTGC/TTGTTC 2 L syn10--------
    rs1994757801,2
    Cuntested156545032(+) TGGCGC/TGTGAA 2 R C mis10--------
    rs1994757811,2
    Cuntested156549367(+) GGATTA/GCTTCA 1 -- int10--------
    rs1994757861,2
    Cuntested156565193(+) GCGCCC/TCTTTG 1 -- int10--------
    rs1994757871,2
    Cuntested156565204(+) CGGGCC/TGGGCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for NLRP5 (56511092 - 56573179 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NLRP5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2646225CNV Deletion19546169
    esv2661813CNV Deletion23128226
    nsv2557CNV Loss18451855
    nsv833883CNV Loss17160897
    dgv206n21CNV Loss19592680
    nsv912507CNV Gain21882294
    nsv912511CNV Gain21882294
    nsv912510CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609658    OMIM disorders: --

    8 diseases for NLRP5:    About MalaCards
    autoimmune polyendocrine syndrome type 1    oophoritis    autoimmune polyendocrine syndrome    hypoparathyroidism
    crohn's disease    chronic lymphocytic leukemia    leukemia    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for NLRP5:
    Autoimmune polyendocrine syndrome type 1     Hypoparathyroidism

    NLRP5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NLRP5
    Human Genome Epidemiology (HuGE) Navigator: NLRP5 (4 documents)

    Export disorders for NLRP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NLRP5 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with NLRP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NALPs: a novel protein family involved in inflammation. (PubMed id 12563287)1, 2, 3 Tschopp J....Burns K. (2003)
    2. A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development. (PubMed id 11925379)1, 2, 3 Tong Z.-B.... Nelson L.M. (2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    5. The genetics of NOD-like receptors in Crohn's disease . (PubMed id 20403135)1, 4 Cummings J.R....Jewell D.P. (2010)
    6. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Human MATER localization in specific cell domains of oocytes and follicular cells. (PubMed id 19192343)1 Sena P....De Pol A. (2009)
    9. MATER protein as substrate of PKCepsilon in human cum ulus cells. (PubMed id 19542546)1 Maraldi T....De Pol A. (2009)
    10. Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen. (PubMed id 18322283)1 Alimohammadi M....Kampe O. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 126206 HGNC: 21269 AceView: NALP5 Ensembl:ENSG00000171487 euGenes: HUgn126206
    ECgene: NLRP5 H-InvDB: NLRP5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NLRP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NLRP5 gene:
    Search GeneIP for patents involving NLRP5

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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