Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NLRP5 Gene

Aliases for NLRP5 Gene

  • NLR Family, Pyrin Domain Containing 5 2 3
  • NALP5 3 4 6
  • MATER 3 4 6
  • NACHT, Leucine Rich Repeat And PYD Containing 5 2 3
  • Maternal Antigen That Embryos Require 2 3
  • Mater Protein Homolog 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 5 3
  • Leucine Rich Repeat And Pyrin Domain Containing 5 2
  • NACHT, LRR And PYD Domains-Containing Protein 5 3
  • Nucleotide-Binding Oligomerization Domain 2
  • CLR19.8 3
  • PYPAF8 3
  • PAN11 3

External Ids for NLRP5 Gene

Previous HGNC Symbols for NLRP5 Gene

  • NALP5

Previous GeneCards Identifiers for NLRP5 Gene

  • GC19P061203
  • GC19P056511
  • GC19P052821

Summaries for NLRP5 Gene

Entrez Gene Summary for NLRP5 Gene

  • The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for NLRP5 Gene

NLRP5 (NLR Family, Pyrin Domain Containing 5) is a Protein Coding gene. Diseases associated with NLRP5 include autoimmune polyendocrine syndrome type 1. An important paralog of this gene is NLRC3.

UniProtKB/Swiss-Prot for NLRP5 Gene

  • As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.

Gene Wiki entry for NLRP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP5 Gene

Genomics for NLRP5 Gene

Regulatory Elements for NLRP5 Gene

Genomic Location for NLRP5 Gene

55,999,726 bp from pter
56,061,813 bp from pter
62,088 bases
Plus strand

Genomic View for NLRP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLRP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP5 Gene

Proteins for NLRP5 Gene

  • Protein details for NLRP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • A8MTY4
    • Q86W29

    Protein attributes for NLRP5 Gene

    1200 amino acids
    Molecular mass:
    134342 Da
    Quaternary structure:
    • Component of the SCMC which also includes at least OOEP and TLE6.

neXtProt entry for NLRP5 Gene

Proteomics data for NLRP5 Gene at MOPED

Post-translational modifications for NLRP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NLRP5 Gene

Domains for NLRP5 Gene

Gene Families for NLRP5 Gene

  • NLR :Nucleotide-binding domain and leucine rich repeat containing

Suggested Antigen Peptide Sequences for NLRP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P59047
  • Contains 1 DAPIN domain.
  • Contains 1 NACHT domain.
  • Belongs to the NLRP family.
  • Contains 13 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRP5: view

Function for NLRP5 Gene

Molecular function for NLRP5 Gene

UniProtKB/Swiss-Prot Function: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.

Gene Ontology (GO) - Molecular Function for NLRP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRP5: view
genes like me logo Genes that share phenotypes with NLRP5: view

Animal Models for NLRP5 Gene

MGI Knock Outs for NLRP5:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NLRP5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NLRP5 Gene

Localization for NLRP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRP5 Gene

Mitochondrion. Nucleus, nucleolus. Cytoplasm. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for NLRP5 Gene COMPARTMENTS Subcellular localization image for NLRP5 gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for NLRP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus ISS --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion ISS --
GO:0005829 cytosol IEA --
GO:0005938 cell cortex --
genes like me logo Genes that share ontologies with NLRP5: view

Pathways for NLRP5 Gene

SuperPathways for NLRP5 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for NLRP5 Gene

Gene Ontology (GO) - Biological Process for NLRP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0007566 embryo implantation IEA --
GO:0009566 fertilization IEA --
GO:0009887 organ morphogenesis IEA --
GO:0031647 regulation of protein stability IEA --
genes like me logo Genes that share ontologies with NLRP5: view

No data available for Pathways by source for NLRP5 Gene

Transcripts for NLRP5 Gene

mRNA/cDNA for NLRP5 Gene

(2) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NLRP5 Gene

NLR family, pyrin domain containing 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NLRP5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NLRP5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP5 Gene

No ASD Table

Relevant External Links for NLRP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLRP5 Gene

mRNA expression in normal human tissues for NLRP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP5 Gene

This gene is overexpressed in Ovary (36.4) and Testis (9.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NLRP5 Gene

SOURCE GeneReport for Unigene cluster for NLRP5 Gene Hs.356872

mRNA Expression by UniProt/SwissProt for NLRP5 Gene

Tissue specificity: Oocyte-specific
genes like me logo Genes that share expressions with NLRP5: view

In Situ Assay Products

Orthologs for NLRP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NLRP5 35
  • 97.88 (n)
  • 96.95 (a)
NLRP5 36
  • 97 (a)
(Bos Taurus)
Mammalia NLRP5 35
  • 69.19 (n)
  • 56.53 (a)
NLRP5 36
  • 57 (a)
(Canis familiaris)
Mammalia NLRP5 35
  • 75.89 (n)
  • 65.48 (a)
NLRP5 36
  • 64 (a)
(Mus musculus)
Mammalia Nlrp5 35
  • 66.03 (n)
  • 53.47 (a)
Nlrp5 16
Nlrp5 36
  • 51 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 32 (a)
(Rattus norvegicus)
Mammalia Nlrp5 35
  • 65.6 (n)
  • 54.67 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
Species with no ortholog for NLRP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP5 Gene

Gene Tree for NLRP5 (if available)
Gene Tree for NLRP5 (if available)

Paralogs for NLRP5 Gene

Selected SIMAP similar genes for NLRP5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NLRP5: view

Variants for NLRP5 Gene

Sequence variations from dbSNP and Humsavar for NLRP5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs167385 -- 56,013,676(-) gaatc(A/G)aaaac intron-variant
rs167386 -- 56,045,463(-) cctgc(A/C)tgttg intron-variant
rs170061 -- 56,042,508(-) agcca(A/G)gtgtg intron-variant
rs188629 -- 56,043,824(-) tgagg(A/C)gggca intron-variant
rs188630 -- 56,042,546(-) catgg(C/T)gaaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLRP5 Gene

Variant ID Type Subtype PubMed ID
nsv912507 CNV Gain 21882294
nsv912510 CNV Gain 21882294
nsv833883 CNV Loss 17160897
esv2646225 CNV Deletion 19546169
esv2661813 CNV Deletion 23128226
nsv912511 CNV Gain 21882294
nsv2557 CNV Loss 18451855
dgv206n21 CNV Loss 19592680

Relevant External Links for NLRP5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP5 Gene

Disorders for NLRP5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NLRP5 Gene including...

Search for NLRP5 Gene in MalaCards »

(2) University of Copenhagen DISEASES for NLRP5 Gene

Relevant External Links for NLRP5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NLRP5: view

No data available for UniProtKB/Swiss-Prot for NLRP5 Gene

Publications for NLRP5 Gene

  1. A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development. (PMID: 11925379) Tong Z.-B. … Nelson L.M. (Hum. Reprod. 2002) 2 3 4
  2. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings J.R. … Jewell D.P. (Tissue Antigens 2010) 3 48
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 48

Products for NLRP5 Gene

Sources for NLRP5 Gene

Back to Top