Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NLRP4 Gene

Aliases for NLRP4 Gene

  • NLR Family, Pyrin Domain Containing 4 2 3 5
  • Cancer/Testis Antigen 58 2 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 4 2 3
  • PYRIN-Containing APAF1-Like Protein 4 3 4
  • PYRIN And NACHT-Containing Protein 2 3 4
  • PAAD And NACHT-Containing Protein 2 3 4
  • Ribonuclease Inhibitor 2 3 4
  • PYPAF4 3 4
  • NALP4 3 4
  • CT58 3 4
  • PAN2 3 4
  • RNH2 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 4 3
  • Leucine Rich Repeat And Pyrin Domain Containing 4 2
  • Nucleotide-Binding Oligomerization Domain 2
  • NACHT, LRR And PYD Containing Protein 4 3
  • CLR19.5 3

External Ids for NLRP4 Gene

Previous HGNC Symbols for NLRP4 Gene

  • NALP4

Previous GeneCards Identifiers for NLRP4 Gene

  • GC19P061041
  • GC19P056347
  • GC19P052660

Summaries for NLRP4 Gene

Entrez Gene Summary for NLRP4 Gene

  • NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NLRP4 Gene

NLRP4 (NLR Family, Pyrin Domain Containing 4) is a Protein Coding gene. Among its related pathways are Immune System and Cytosolic sensors of pathogen-associated DNA. An important paralog of this gene is NLRP7.

UniProtKB/Swiss-Prot for NLRP4 Gene

  • May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.

Gene Wiki entry for NLRP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP4 Gene

Genomics for NLRP4 Gene

Regulatory Elements for NLRP4 Gene

Enhancers for NLRP4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NLRP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NLRP4 Gene

Chromosome:
19
Start:
55,836,086 bp from pter
End:
55,881,855 bp from pter
Size:
45,770 bases
Orientation:
Plus strand

Genomic View for NLRP4 Gene

Genes around NLRP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP4 Gene

Proteins for NLRP4 Gene

  • Protein details for NLRP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MN2-NALP4_HUMAN
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 4
    Protein Accession:
    Q96MN2
    Secondary Accessions:
    • Q86W87
    • Q96AY6

    Protein attributes for NLRP4 Gene

    Size:
    994 amino acids
    Molecular mass:
    113415 Da
    Quaternary structure:
    • Interacts with CHUK/IKKA, inhibiting its kinase activity.
    SequenceCaution:
    • Sequence=AAL88672.1; Type=Erroneous termination; Positions=41; Note=Translated as Gln.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NLRP4 Gene

    Alternative splice isoforms for NLRP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NLRP4 Gene

Proteomics data for NLRP4 Gene at MOPED

Post-translational modifications for NLRP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP4 Gene

Antibody Products

  • Abcam antibodies for NALP4

No data available for DME Specific Peptides for NLRP4 Gene

Domains & Families for NLRP4 Gene

Gene Families for NLRP4 Gene

Protein Domains for NLRP4 Gene

Suggested Antigen Peptide Sequences for NLRP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MN2

UniProtKB/Swiss-Prot:

NALP4_HUMAN :
  • The pyrin domain is sufficient for suppression of NF-kappaB activity, it adopts a typical death domain fold, but in contrast to several NLRP family pyrin domains it doesnt bind homotypically to the ASC adapter, which supports the observation that NLRP4 has no effect on IL1B activation.
  • Belongs to the NLRP family.
  • Contains 8 LRR (leucine-rich) repeats.
Domain:
  • The pyrin domain is sufficient for suppression of NF-kappaB activity, it adopts a typical death domain fold, but in contrast to several NLRP family pyrin domains it doesnt bind homotypically to the ASC adapter, which supports the observation that NLRP4 has no effect on IL1B activation.
  • Contains 1 NACHT domain.
  • Contains 1 pyrin domain.
Family:
  • Belongs to the NLRP family.
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRP4: view

Function for NLRP4 Gene

Molecular function for NLRP4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
genes like me logo Genes that share phenotypes with NLRP4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLRP4 Gene

Localization for NLRP4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLRP4 Gene COMPARTMENTS Subcellular localization image for NLRP4 gene
Compartment Confidence
cytosol 5
extracellular 5
endoplasmic reticulum 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NLRP4 Gene

Pathways & Interactions for NLRP4 Gene

genes like me logo Genes that share pathways with NLRP4: view

Gene Ontology (GO) - Biological Process for NLRP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0032479 regulation of type I interferon production TAS --
genes like me logo Genes that share ontologies with NLRP4: view

No data available for SIGNOR curated interactions for NLRP4 Gene

Drugs & Compounds for NLRP4 Gene

No Compound Related Data Available

Transcripts for NLRP4 Gene

Unigene Clusters for NLRP4 Gene

NLR family, pyrin domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2:
SP3: - -
SP4: -
SP5: -

Relevant External Links for NLRP4 Gene

GeneLoc Exon Structure for
NLRP4
ECgene alternative splicing isoforms for
NLRP4

Expression for NLRP4 Gene

mRNA expression in normal human tissues for NLRP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP4 Gene

This gene is overexpressed in Testis (x39.0).

Protein differential expression in normal tissues from HIPED for NLRP4 Gene

This gene is overexpressed in Bone marrow stromal cell (63.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NLRP4 Gene



SOURCE GeneReport for Unigene cluster for NLRP4 Gene Hs.631533

genes like me logo Genes that share expression patterns with NLRP4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NLRP4 Gene

Orthologs for NLRP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP4 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Nlrp4c 35
  • 64.89 (n)
  • 51.38 (a)
Nlrp4e 16
Nlrp4a 36
  • 50 (a)
OneToMany
Nlrp4b 36
  • 45 (a)
OneToMany
Nlrp4c 36
  • 51 (a)
OneToMany
Nlrp4e 36
  • 51 (a)
OneToMany
Nlrp4f 36
  • 47 (a)
OneToMany
Nlrp4g 36
  • 45 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia NLRP4 35
  • 98.86 (n)
  • 98.13 (a)
NLRP4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nlrp4 35
  • 65.68 (n)
  • 52.86 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
OneToMany
Species with no ortholog for NLRP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP4 Gene

ENSEMBL:
Gene Tree for NLRP4 (if available)
TreeFam:
Gene Tree for NLRP4 (if available)

Paralogs for NLRP4 Gene

(15) SIMAP similar genes for NLRP4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NLRP4: view

Variants for NLRP4 Gene

Sequence variations from dbSNP and Humsavar for NLRP4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs302453 - 55,878,871(+) GCAGC(A/T)GCTCA reference, missense
rs441827 - 55,857,823(-) CCCAG(C/T)TTCCT reference, missense
rs17857373 - 55,858,542(+) CCTGA(C/G/T)GGTGC reference, missense
rs17857374 - 55,858,562(+) GACTC(A/C/T)GCAAA reference, missense
rs17854614 - 55,867,842(+) AAGCC(A/C)TGTGC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NLRP4 Gene

Variant ID Type Subtype PubMed ID
nsv510927 CNV Complex 20534489
nsv912505 CNV Gain 21882294
nsv912507 CNV Gain 21882294
nsv820912 CNV Deletion 20802225
esv22163 CNV Loss 19812545
esv2718990 CNV Deletion 23290073
nsv138082 CNV Loss 16902084
esv2674964 CNV Deletion 23128226
esv2718991 CNV Deletion 23290073
esv1278224 CNV Deletion 17803354
esv2718992 CNV Deletion 23290073
esv2718993 CNV Deletion 23290073
nsv912508 CNV Gain 21882294
nsv912509 CNV Gain 21882294
esv2718994 CNV Deletion 23290073
esv2718996 CNV Deletion 23290073
esv2718997 CNV Deletion 23290073
esv2718998 CNV Deletion 23290073
esv2718999 CNV Deletion 23290073
esv2719000 CNV Deletion 23290073
nsv507901 CNV Insertion 20534489

Variation tolerance for NLRP4 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NLRP4 Gene

Disorders for NLRP4 Gene

Relevant External Links for NLRP4

Genetic Association Database (GAD)
NLRP4
Human Genome Epidemiology (HuGE) Navigator
NLRP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NLRP4

No disorders were found for NLRP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP4 Gene

Publications for NLRP4 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4 67
  2. Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. (PMID: 15107016) Damiano J.S. … Reed J.C. (Biochem. J. 2004) 3 23
  3. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. (PMID: 12019269) Wang L. … Bertin J. (J. Biol. Chem. 2002) 2 3
  4. Isolation and expression analysis of the human RNH2 gene encoding ribonuclease inhibitor 2. (PMID: 12182447) Miyamoto T. … Hasuike S. (J. Assist. Reprod. Genet. 2002) 3 23
  5. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. (PMID: 12387869) Grenier J.M. … Bertin J. (FEBS Lett. 2002) 3 23

Products for NLRP4 Gene

Sources for NLRP4 Gene

Content