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NLRP4 Gene

protein-coding   GIFtS: 58
GCID: GC19P056347

NLR Family, Pyrin Domain Containing 4

(Previous names: NACHT, leucine rich repeat and PYD containing 4)
(Previous symbol: NALP4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NLR Family, Pyrin Domain Containing 41 2     PAAD And NACHT-Containing Protein 22 3
NALP41 2 3 5     PYRIN And NACHT-Containing Protein 22 3
Cancer/Testis Antigen 581 2 3     PYRIN-Containing APAF1-Like Protein 42 3
PAN22 3 5     Leucine Rich Repeat And Pyrin Domain Containing 41
PYPAF42 3 5     Nucleotide-Binding Oligomerization Domain1
NACHT, Leucine Rich Repeat And PYD Containing 41 2     CLR19.52
Ribonuclease Inhibitor 22 3     NACHT, LRR And PYD Containing Protein 42
CT582 3     NACHT, LRR And PYD Domains-Containing Protein 42
RNH22 3     Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin
Domain Containing 42

External Ids:    HGNC: 229431   Entrez Gene: 1479452   Ensembl: ENSG000001605057   OMIM: 6096455   UniProtKB: Q96MN23   

Export aliases for NLRP4 gene to outside databases

Previous GC identifers: GC19P061041 GC19P052660


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NLRP4 Gene:
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short
NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a
NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM
606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment
domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via
their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 (PubMed
12563287)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NLRP4 Gene:
NLRP4 (NLR family, pyrin domain containing 4) is a protein-coding gene. Diseases associated with NLRP4 include crohn's disease, and chronic lymphocytic leukemia. An important paralog of this gene is NLRP13.

UniProtKB/Swiss-Prot: NALP4_HUMAN, Q96MN2
Function: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns
(PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon
signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its
subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it
operates at a point of convergence in these two cytokine signaling pathways

Gene Wiki entry for NLRP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NLRP4 gene promoter:
         AML1a   NF-kappaB   CBF-C   E47   AREB6   CBF-A   CBF-B   CP1C   CP1A   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLRP4 promoter sequence
   Search Chromatin IP Primers for NLRP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NLRP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

NLRP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLRP4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P056347:  view genomic region     (about GC identifiers)

Start:
56,347,944 bp from pter      End:
56,393,221 bp from pter
Size:
45,278 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NALP4_HUMAN, Q96MN2 (See protein sequence)
Recommended Name: NACHT, LRR and PYD domains-containing protein 4  
Size: 994 amino acids; 113415 Da
Subunit: Interacts with CHUK/IKKA, inhibiting its kinase activity
Sequence caution: Sequence=AAL88672.1; Type=Erroneous termination; Positions=41; Note=Translated as Gln;
1 PDB 3D structure from and Proteopedia for NLRP4:
4EWI (3D)    
Secondary accessions: Q86W87 Q96AY6
Alternative splicing: 3 isoforms:  Q96MN2-1   Q96MN2-2   Q96MN2-3   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for NLRP4: NX_Q96MN2

Explore proteomics data for NLRP4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NLRP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_604393.2  
    ENSEMBL proteins: 
     ENSP00000301295   ENSP00000468496   ENSP00000465463   ENSP00000468754   ENSP00000344787  
    Reactome Protein details: Q96MN2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NLR: Nucleotide-binding domain and leucine rich repeat containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: NLRP4
    NOD-like receptor family

    4 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR007111 NACHT_NTPase
     IPR027417 P-loop_NTPase
     IPR004020 DAPIN

    Graphical View of Domain Structure for InterPro Entry Q96MN2

    ProtoNet protein and cluster: Q96MN2

    1 Blocks protein domain: IPB004020 Pyrin domain

    UniProtKB/Swiss-Prot: NALP4_HUMAN, Q96MN2
    Domain: The DAPIN/Pyrin domain is sufficient for suppression of NF-kappaB activity, it adopts a typical death
    domain fold, but in contrast to several NLRP family DAPIN domains it doesn't bind homotypically to the ASC
    adapter, which supports the observation that NLRP4 has no effect on IL1B activation
    Similarity: Belongs to the NLRP family
    Similarity: Contains 1 DAPIN domain
    Similarity: Contains 8 LRR (leucine-rich) repeats
    Similarity: Contains 1 NACHT domain


    NLRP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NALP4_HUMAN, Q96MN2
    Function: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns
    (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon
    signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its
    subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it
    operates at a point of convergence in these two cytokine signaling pathways

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
         
    NLRP4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NLRP4:
     Increased HPV18 LCR reporter a 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target NLRP4:
    hsa-mir-29a-3p (MIRT049988), hsa-mir-222-3p (MIRT046587)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    NLRP4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NLRP4 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytosolic sensors of pathogen-associated DNA
    ZBP1(DAI) mediated induction of type I IFNs0.81
    Regulation of innate immune responses to cytosolic DNA0.00
    Cytosolic sensors of pathogen-associated DNA0.38
    STING mediated induction of host immune responses0.00
    IRF3 mediated activation of type 1 IFN0.00
    IRF3-mediated induction of type I IFN0.00
    2Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD pathway0.33
    3TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NLRP4
        NOD pathway
    TNF-alpha/NF-kB Signaling Pathway

    3 Reactome Pathways for NLRP4
        Regulation of innate immune responses to cytosolic DNA
    IRF3 mediated activation of type 1 IFN
    IRF3-mediated induction of type I IFN



    NLRP4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NLRP4: 
              Inflammasomes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NLRP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for NLRP4 (Q96MN23 ENSP000003012954) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHUKO151113, ENSP000003594244I2D: score=2 STRING: ENSP00000359424
    SUGT1Q9Y2Z03, ENSP000003672084I2D: score=1 STRING: ENSP00000367208
    NLRC4Q9NPP43, ENSP000003541594I2D: score=3 STRING: ENSP00000354159
    DTX4ENSP000002274514STRING: ENSP00000227451
    TBK1ENSP000003299674STRING: ENSP00000329967
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0032479regulation of type I interferon production TAS--
    GO:0032481positive regulation of type I interferon production TAS--
    GO:0045087innate immune response TAS--

    NLRP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NLRP4 (NALP4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NLRP4 gene: 
    NM_134444.4  

    Unigene Cluster for NLRP4:

    NLR family, pyrin domain containing 4
    Hs.631533  [show with all ESTs]
    Unigene Representative Sequence: NM_134444
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301295(uc002qmd.4 uc002qmf.3) ENST00000587464 ENST00000587891
    ENST00000589437 ENST00000346986(uc010etf.3)
    miRNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat NLRP4

    Additional mRNA sequence: 

    AF442488.1 AF479747.1 AF482706.1 AK315003.1 AY072792.1 BC012789.2 BC016443.1 BC021272.2 
    BC050326.1 

    4 DOTS entries:

    DT.104757  DT.91750526  DT.95263231  DT.95263232 

    Selected AceView cDNA sequences (see all 30):

    BE018433 AK056688 BG481869 BE278595 BE278926 AI204456 BX091036 NM_134444 
    AA421483 BC016443 BM457898 CF138560 BG772562 BE902227 BG341650 AI825059 
    BC050326 AF479747 AY072792 BC012789 AF442488 AF482706 BE535932 AA421452 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NLRP4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:              -                                                                     
    SP2:                                                                                    
    SP3:                                            -     -                                 
    SP4:                                                              -                     
    SP5:              -                                                                     


    ECgene alternative splicing isoforms for NLRP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NLRP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTGCACC
    NLRP4 Expression
    About this image


    NLRP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
    NLRP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NLRP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631533
        Pathway & Disease-focused RT2 Profiler PCR Array including NLRP4: 
              Inflammasomes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NLRP4 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nlrp4e5
    Nlrp4c1
    NLR family, pyrin domain containing 4E5
    NLR family, pyrin domain containing 4C1
    64.89(n)1
    51.38(a)1
      7 (10.21 cM)5
    835641  NM_031389.21  NP_113566.21 
     233012755 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    30(a)
    1 → many
    GL343482.1(99797-117577)


    ENSEMBL Gene Tree for NLRP4 (if available)
    TreeFam Gene Tree for NLRP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NLRP4 gene
    NLRP132  NLRP92  NLRC32  NLRP62  NLRP32  NLRP142  NLRP72  NLRP112  
    NLRP102  NLRP22  NLRP52  NLRP82  NLRP122  
    15 SIMAP similar genes for NLRP4 using alignment to 4 protein entries:     NALP4_HUMAN (see all proteins):
    MEFV    NLRP9    PYDC2    CIAS1    NLRP14    RNH1
    PP1579    NLRP11    NLRP2    NLRP7    NLRP3    NLRP8
    NLRP12    NLRP13    NLRP5

    NLRP4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NLRP4 (see all 1570)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1994757471,2
    Cuntested156370665(+) GTATTC/TCCAAG 1 -- int10--------
    rs4425101,2
    C,F,A--56350150(-) tagaaG/Cataaa 1 -- int19Minor allele frequency- C:0.17NA WA CSA EA 370
    rs3853491,2
    C,F,A,H--56350247(-) TAAGTG/Ttaaga 1 -- int122Minor allele frequency- T:0.22NS EA NA WA CSA 2356
    rs1893915021,2
    --56350253(+) ACTTAA/CTGGAC 1 -- int10--------
    rs4002971,2
    C,F,A,H--56350289(+) CAAGTA/GGACCG 1 -- int126Minor allele frequency- G:0.21NS EA NA WA CSA 2774
    rs3849141,2
    C,F,A--56350394(-) gtgtaC/Taccta 1 -- int18Minor allele frequency- T:0.17MN NA CSA WA EA 550
    rs1809977911,2
    --56350443(+) TAGGTG/TTTAAG 1 -- int10--------
    rs1480237161,2
    C--56350465(+) TTAGGC/TATTTG 1 -- int10--------
    rs1854533521,2
    --56350526(+) TGTGAA/GTGTTC 1 -- int10--------
    rs1437461851,2
    --56350549(+) CCGTTC/TGTGTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for NLRP4 (56347944 - 56393221 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NLRP4 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718990CNV Deletion23290073
    esv2674964CNV Deletion23128226
    esv2718993CNV Deletion23290073
    esv1278224CNV Deletion17803354
    esv2718997CNV Deletion23290073
    esv2719000CNV Deletion23290073
    esv2718999CNV Deletion23290073
    esv2718994CNV Deletion23290073
    esv2718996CNV Deletion23290073
    nsv820912CNV Deletion20802225

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609645    OMIM disorders: --

    3 diseases for NLRP4:    
    About MalaCards
    crohn's disease    chronic lymphocytic leukemia    leukemia


    NLRP4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NLRP4
    Human Genome Epidemiology (HuGE) Navigator: NLRP4 (2 documents)

    Export disorders for NLRP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NLRP4 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with NLRP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NALPs: a novel protein family involved in inflammation. (PubMed id 12563287)1, 2, 3 Tschopp J.... Burns K. (Nat. Rev. Mol. Cell Biol. 2003)
    2. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. (PubMed id 12387869)1, 2, 9 Grenier J.M.... Bertin J. (FEBS Lett. 2002)
    3. NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4. (PubMed id 22388039)1, 2 Cui J.... Wang R.F. (Nat. Immunol. 2012)
    4. Structural and functional analysis of the NLRP4 pyrin domain. (PubMed id 22928810)1, 2 Eibl C....Peti W. (Biochemistry 2012)
    5. The genetics of NOD-like receptors in Crohn's disease. (PubMed id 20403135)1, 4 Cummings J.R....Jewell D.P. (Tissue Antigens 2010)
    6. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta. (PubMed id 12093792)1, 2 Fiorentino L....Reed J.C. (J. Biol. Chem. 2002)
    10. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. (PubMed id 12019269)1, 3 Wang L.... Bertin J. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 147945 HGNC: 22943 AceView: NALP4 Ensembl:ENSG00000160505 euGenes: HUgn147945
    ECgene: NLRP4 H-InvDB: NLRP4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NLRP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NLRP4 gene:
    Search GeneIP for patents involving NLRP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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