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Aliases for NLRP2P Gene

Aliases for NLRP2P Gene

  • NLR Family, Pyrin Domain Containing 2 Pseudogene 2 3 5
  • NLR Family And Pyrin Domain-Containing 2 Pseudogene 3 4
  • Pyrin-Only Protein 4 3 4
  • CLRX.1 3 4
  • NOD24 3 4
  • POP4 3 4
  • Pyrin Domain-Containing Protein 2-Like Protein POP4 3
  • NOD24 Pseudogene 3
  • NALP2P 3

External Ids for NLRP2P Gene

Previous GeneCards Identifiers for NLRP2P Gene

  • GC0XM057720

Summaries for NLRP2P Gene

GeneCards Summary for NLRP2P Gene

NLRP2P (NLR Family, Pyrin Domain Containing 2 Pseudogene) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. An important paralog of this gene is PYDC2.

UniProtKB/Swiss-Prot for NLRP2P Gene

  • May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at Ser-536, thereby inhibiting its transcriptional activity. Through NF-kappa-B regulation may control cytokine release upon Toll-like receptors activation and therefore play a role in modulation of innate immunity. May also play a role in cell cycle progression and apoptotic process.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP2P Gene

Genomics for NLRP2P Gene

Genomic Location for NLRP2P Gene

Chromosome:
X
Start:
57,676,818 bp from pter
End:
57,680,280 bp from pter
Size:
3,463 bases
Orientation:
Minus strand

Genomic View for NLRP2P Gene

Genes around NLRP2P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP2P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP2P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP2P Gene

No data available for Regulatory Elements for NLRP2P Gene

Proteins for NLRP2P Gene

  • Protein details for NLRP2P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMW2-PYDC4_HUMAN
    Recommended name:
    Pyrin domain-containing protein 2-like protein POP4
    Protein Accession:
    P0DMW2

    Protein attributes for NLRP2P Gene

    Size:
    45 amino acids
    Molecular mass:
    4993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NLRP2P Gene

Proteomics data for NLRP2P Gene at MOPED

Post-translational modifications for NLRP2P Gene

No Post-translational modifications

Other Protein References for NLRP2P Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NLRP2P Gene

Domains & Families for NLRP2P Gene

Gene Families for NLRP2P Gene

Protein Domains for NLRP2P Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NLRP2P: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NLRP2P Gene

Function for NLRP2P Gene

Molecular function for NLRP2P Gene

UniProtKB/Swiss-Prot Function:
May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at Ser-536, thereby inhibiting its transcriptional activity. Through NF-kappa-B regulation may control cytokine release upon Toll-like receptors activation and therefore play a role in modulation of innate immunity. May also play a role in cell cycle progression and apoptotic process.
UniProtKB/Swiss-Prot Induction:
Up-regulated by inflammatory stimulus (LPS).

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NLRP2P Gene

Localization for NLRP2P Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRP2P Gene

Cytoplasm. Nucleus. Note=Targeted to the nucleus upon TNF-alpha treatment. {ECO:0000269 PubMed:24871464}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NLRP2P Gene

Pathways & Interactions for NLRP2P Gene

genes like me logo Genes that share pathways with NLRP2P: view

Pathways by source for NLRP2P Gene

3 Reactome pathways for NLRP2P Gene
2 KEGG pathways for NLRP2P Gene

Interacting Proteins for NLRP2P Gene

Gene Ontology (GO) - Biological Process for NLRP2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IMP 24871464
GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP 24871464
GO:0033137 negative regulation of peptidyl-serine phosphorylation IMP 24871464
GO:0034122 negative regulation of toll-like receptor signaling pathway IMP 24871464
GO:0043065 positive regulation of apoptotic process IMP 24871464
genes like me logo Genes that share ontologies with NLRP2P: view

No data available for SIGNOR curated interactions for NLRP2P Gene

Drugs & Compounds for NLRP2P Gene

No Compound Related Data Available

Transcripts for NLRP2P Gene

mRNA/cDNA for NLRP2P Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP2P Gene

No ASD Table

Relevant External Links for NLRP2P Gene

GeneLoc Exon Structure for
NLRP2P
ECgene alternative splicing isoforms for
NLRP2P

Expression for NLRP2P Gene

mRNA expression in normal human tissues for NLRP2P Gene

mRNA differential expression in normal tissues according to GTEx for NLRP2P Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.8) and Brain - Cerebellum (x4.3).

mRNA Expression by UniProt/SwissProt for NLRP2P Gene

P0DMW2-PYDC4_HUMAN
Tissue specificity: Expressed in all tissues tested, including spleen, lymph node, thymus, tonsil, peripheral blood leukocyte, bone marrow, liver, heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with NLRP2P: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NLRP2P Gene

Orthologs for NLRP2P Gene

Evolution for NLRP2P Gene

ENSEMBL:
Gene Tree for NLRP2P (if available)
TreeFam:
Gene Tree for NLRP2P (if available)

No data available for Orthologs for NLRP2P Gene

Paralogs for NLRP2P Gene

Paralogs for NLRP2P Gene

genes like me logo Genes that share paralogs with NLRP2P: view

Variants for NLRP2P Gene

Relevant External Links for NLRP2P Gene

HapMap Linkage Disequilibrium report
NLRP2P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for NLRP2P Gene

Disorders for NLRP2P Gene

Relevant External Links for NLRP2P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NLRP2P

No disorders were found for NLRP2P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP2P Gene

Publications for NLRP2P Gene

  1. The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-I_B, pyrin-only protein 4. (PMID: 24871464) Porter K.A. … Harton J.A. (Genes Immun. 2014) 2 3 4 67
  2. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N. … Nunez G. (Nat. Rev. Immunol. 2003) 2 3
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3

Products for NLRP2P Gene

Sources for NLRP2P Gene

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