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Aliases for NLRP2B Gene

Aliases for NLRP2B Gene

  • NLR Family Pyrin Domain Containing 2B 2 3 5
  • NLR Family And Pyrin Domain-Containing 2 Pseudogene 3 4
  • NLR Family, Pyrin Domain Containing 2 Pseudogene 2 3
  • Pyrin-Only Protein 4 3 4
  • NLRP2P 3 4
  • CLRX.1 3 4
  • NOD24 3 4
  • POP4 3 4
  • Pyrin Domain-Containing Protein 2-Like Protein POP4 3
  • NOD24 Pseudogene 3
  • NALP2P 3

External Ids for NLRP2B Gene

Previous HGNC Symbols for NLRP2B Gene

  • NLRP2P

Summaries for NLRP2B Gene

GeneCards Summary for NLRP2B Gene

NLRP2B (NLR Family Pyrin Domain Containing 2B) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NLRP2B Gene

  • May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at Ser-536, thereby inhibiting its transcriptional activity. Through NF-kappa-B regulation may control cytokine release upon Toll-like receptors activation and therefore play a role in modulation of innate immunity. May also play a role in cell cycle progression and apoptotic process.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP2B Gene

Genomics for NLRP2B Gene

Genomic Location for NLRP2B Gene

Chromosome:
X
Start:
57,676,818 bp from pter
End:
57,680,280 bp from pter
Size:
3,463 bases
Orientation:
Minus strand

Genomic View for NLRP2B Gene

Genes around NLRP2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP2B Gene

No data available for Regulatory Elements for NLRP2B Gene

Proteins for NLRP2B Gene

  • Protein details for NLRP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMW2-PYDC4_HUMAN
    Recommended name:
    Pyrin domain-containing protein 2-like protein POP4
    Protein Accession:
    P0DMW2

    Protein attributes for NLRP2B Gene

    Size:
    45 amino acids
    Molecular mass:
    4993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NLRP2B Gene

Post-translational modifications for NLRP2B Gene

No Post-translational modifications

Other Protein References for NLRP2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NLRP2B Gene

Domains & Families for NLRP2B Gene

Gene Families for NLRP2B Gene

Protein Domains for NLRP2B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NLRP2B: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NLRP2B Gene

Function for NLRP2B Gene

Molecular function for NLRP2B Gene

UniProtKB/Swiss-Prot Function:
May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at Ser-536, thereby inhibiting its transcriptional activity. Through NF-kappa-B regulation may control cytokine release upon Toll-like receptors activation and therefore play a role in modulation of innate immunity. May also play a role in cell cycle progression and apoptotic process.
UniProtKB/Swiss-Prot Induction:
Up-regulated by inflammatory stimulus (LPS).

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NLRP2B Gene

Localization for NLRP2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRP2B Gene

Cytoplasm. Nucleus. Note=Targeted to the nucleus upon TNF-alpha treatment. {ECO:0000269 PubMed:24871464}.

Gene Ontology (GO) - Cellular Components for NLRP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24871464
GO:0005737 cytoplasm IDA 24871464
genes like me logo Genes that share ontologies with NLRP2B: view

No data available for Subcellular locations from COMPARTMENTS for NLRP2B Gene

Pathways & Interactions for NLRP2B Gene

SuperPathways for NLRP2B Gene

No Data Available

Interacting Proteins for NLRP2B Gene

Gene Ontology (GO) - Biological Process for NLRP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IMP 24871464
GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP 24871464
GO:0033137 negative regulation of peptidyl-serine phosphorylation IMP 24871464
GO:0034122 negative regulation of toll-like receptor signaling pathway IMP 24871464
GO:0043065 positive regulation of apoptotic process IMP 24871464
genes like me logo Genes that share ontologies with NLRP2B: view

No data available for Pathways by source and SIGNOR curated interactions for NLRP2B Gene

Drugs & Compounds for NLRP2B Gene

No Compound Related Data Available

Transcripts for NLRP2B Gene

mRNA/cDNA for NLRP2B Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP2B Gene

No ASD Table

Relevant External Links for NLRP2B Gene

GeneLoc Exon Structure for
NLRP2B
ECgene alternative splicing isoforms for
NLRP2B

Expression for NLRP2B Gene

NURSA nuclear receptor signaling pathways regulating expression of NLRP2B Gene:

NLRP2B

mRNA Expression by UniProt/SwissProt for NLRP2B Gene:

P0DMW2-PYDC4_HUMAN
Tissue specificity: Expressed in all tissues tested, including spleen, lymph node, thymus, tonsil, peripheral blood leukocyte, bone marrow, liver, heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NLRP2B Gene

Orthologs for NLRP2B Gene

Evolution for NLRP2B Gene

ENSEMBL:
Gene Tree for NLRP2B (if available)
TreeFam:
Gene Tree for NLRP2B (if available)

No data available for Orthologs for NLRP2B Gene

Paralogs for NLRP2B Gene

No data available for Paralogs for NLRP2B Gene

Variants for NLRP2B Gene

Relevant External Links for NLRP2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NLRP2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for NLRP2B Gene

Disorders for NLRP2B Gene

Relevant External Links for NLRP2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NLRP2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NLRP2B

No disorders were found for NLRP2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP2B Gene

Publications for NLRP2B Gene

  1. The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-I_B, pyrin-only protein 4. (PMID: 24871464) Porter K.A. … Harton J.A. (Genes Immun. 2014) 2 3 4 65
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 65
  3. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N. … Nunez G. (Nat. Rev. Immunol. 2003) 2 3 65

Products for NLRP2B Gene

Sources for NLRP2B Gene

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