Aliases for NLRP2B Gene
External Ids for NLRP2B Gene
Previous HGNC Symbols for NLRP2B Gene
GeneCards Summary for NLRP2B Gene
NLRP2B (NLR Family Pyrin Domain Containing 2B) is a Protein Coding gene. An important paralog of this gene is PYDC2.
UniProtKB/Swiss-Prot for NLRP2B Gene
May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at Ser-536, thereby inhibiting its transcriptional activity. Through NF-kappa-B regulation may control cytokine release upon Toll-like receptors activation and therefore play a role in modulation of innate immunity. May also play a role in cell cycle progression and apoptotic process.