Aliases for NLRP2 Gene
External Ids for NLRP2 Gene
Previous HGNC Symbols for NLRP2 Gene
Previous GeneCards Identifiers for NLRP2 Gene
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
GeneCards Summary for NLRP2 Gene
NLRP2 (NLR Family, Pyrin Domain Containing 2) is a Protein Coding gene. Diseases associated with NLRP2 include gestational trophoblastic neoplasm and spondyloarthropathy. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and ERK Signaling. GO annotations related to this gene include Pyrin domain binding. An important paralog of this gene is NLRP7.
UniProtKB/Swiss-Prot for NLRP2 Gene
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.