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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NLRP2 Gene

protein-coding   GIFtS: 57
GCID: GC19P055476

NLR family, pyrin domain containing 2

(Previous names: NACHT, leucine rich repeat and PYD containing 2 )
(Previous symbol: NALP2)
 Explore 10 diseases affiliated with
NLRP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NLRP2    

Aliases
for NLRP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NLR Family, Pyrin Domain Containing 21 2     Nucleotide-Binding Site Protein 12 3
NALP21 2 3 5     PYRIN Domain And NACHT Domain-Containing Protein 12 3
PAN11 2 3 5     PYRIN-Containing APAF1-Like Protein 22 3
PYPAF21 2 3 5     FLJ205101
NBS11 2 3     NACHT, LRR And PYD Containing Protein 22
CLR19.91 2     NACHT, LRR And PYD Domains-Containing Protein 22
NACHT, Leucine Rich Repeat And PYD Containing 21 2     Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain
Containing 22

External Ids:    HGNC: 229481   Entrez Gene: 556552   Ensembl: ENSG000000225567   OMIM: 6093645   UniProtKB: Q9NX023   

Export aliases for NLRP2 gene to outside databases

Previous GC identifers: GC19P060170 GC19P051800


Summaries
for NLRP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NLRP2:
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in
the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be
involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 (PubMed
12563287)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: NALP2_HUMAN, Q9NX02
Function: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA
degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature
proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD,
CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases

Gene Wiki entry for NLRP2


Genomic Views
for NLRP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NLRP2 gene promoter:
         Max1   USF1   AP-1   ATF-2   STAT1beta   HSF1 (long)   USF-1   HSF1short   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NLRP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NLRP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLRP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

NLRP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLRP2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055476:  view genomic region     (about GC identifiers)

Start:
 55,464,498 bp from pter      End:
 55,512,510 bp from pter
Size:
 48,013 bases      Orientation:
 plus strand

Proteins
for NLRP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NALP2_HUMAN, Q9NX02 (See protein sequence)
Recommended Name: NACHT, LRR and PYD domains-containing protein 2  
Size: 1062 amino acids; 120515 Da
Subunit: Interacts with CHUK, IKBKB and IKBKG, as well as with full-length PYCARD and with the DAPIN domain of NAPL1,
but not the full-length protein
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAG15253.1; Type=Erroneous initiation; Sequence=BAA91377.1; Type=Erroneous initiation;
Sequence=BAD92537.1; Type=Frameshift; Positions=769; Sequence=BAD92537.1; Type=Miscellaneous discrepancy;
Note=Erroneous prediction of the initiator methionine;
Secondary accessions: B4DZL7 I3L0G4 Q53FL5 Q59G09 Q8IXT0 Q9BVN5 Q9H6G6 Q9HAV9 Q9NWK3
Alternative splicing: 5 isoforms:  Q9NX02-1   Q9NX02-2   Q9NX02-3   Q9NX02-4   Q9NX02-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NLRP2: NX_Q9NX02

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NX02

    • NLRP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001167552.1  NP_001167553.1  NP_001167554.1  NP_060322.1  

    ENSEMBL proteins: 
     ENSP00000466260   ENSP00000465069   ENSP00000443519   ENSP00000445135   ENSP00000375601  
     ENSP00000344074   ENSP00000442351   ENSP00000467349   ENSP00000402474   ENSP00000263437  
     ENSP00000441363   ENSP00000466537   ENSP00000445846   ENSP00000409370   ENSP00000440601  
     ENSP00000441133  

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    Novus Biologicals NLRP2 Proteins
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    Uscn Proteins for NLRP2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15030775


    NLRP2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NLRP2

    Protein Domains /
    Families
    for NLRP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NLRP2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR007111 NACHT_NTPase
     IPR004020 DAPIN
     IPR011029 DEATH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NX02

    ProtoNet protein and cluster: Q9NX02

    3 Blocks protein families:
    IPB000767 Disease resistance protein signature
    IPB001611 Leucine-rich repeat signature
    IPB004020 Pyrin domain


    UniProtKB/Swiss-Prot: NALP2_HUMAN, Q9NX02
    Domain: The DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for
    inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD
    Domain: When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the
    full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein
    folding
    Similarity: Belongs to the NLRP family
    Similarity: Contains 1 DAPIN domain
    Similarity: Contains 8 LRR (leucine-rich) repeats
    Similarity: Contains 1 NACHT domain


    Function
    for NLRP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NALP2_HUMAN, Q9NX02
    Function: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA
    degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature
    proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD,
    CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases
    Induction: By interferons and bacterial lipopolysaccharides (LPS)

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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17178784
    GO:0005524ATP binding IEA--
    GO:0032090Pyrin domain binding IPI15030775


    NLRP2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for NLRP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    		NOD pathway0.23


    1 BioSystems Pathway for NLRP2 
        NOD pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NLRP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/16 Interacting proteins for NLRP2 (Q9NX021, 2, 3 ENSP000002634374) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H2AFXP161042, 3, ENSP000003643104MINT-56624 MINT-56625 MINT-56627 I2D: score=1 STRING: ENSP00000364310
    PYDC2Q56P421, 3EBI-6374482,EBI-6374418 I2D: score=1 
    WRNQ141912, 3, ENSP000002981394MINT-56617 I2D: score=1 STRING: ENSP00000298139
    CARD8Q9Y2G23, ENSP000003519014I2D: score=1 STRING: ENSP00000351901
    MRE11AP499593, ENSP000003258634I2D: score=1 STRING: ENSP00000325863
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA15030775
    GO:0050718positive regulation of interleukin-1 beta secretion IDA15030775


    NLRP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NLRP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NLRP2
    Search CenterWatch for drugs/clinical trials and news about NLRP2 / NALP2 

    Transcripts
    for NLRP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NLRP2 gene (4 alternative transcripts): 
    NM_001174081.1  NM_001174082.1  NM_001174083.1  NM_017852.3  

    Unigene Cluster for NLRP2:

    NLR family, pyrin domain containing 2
    Hs.369279  [show with all ESTs]
    Unigene Representative Sequence: NM_017852
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000588619 ENST00000588107 ENST00000433772 ENST00000543010(uc021vbq.1)
    ENST00000540597 ENST00000391721 ENST00000339757 ENST00000539848 ENST00000585500
    ENST00000427260 ENST00000263437 ENST00000397169 ENST00000540005 ENST00000543277
    ENST00000381637 ENST00000586512 ENST00000542755 ENST00000448584(uc010yfp.2 uc002qij.3 uc010esn.3 uc010eso.3)


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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB209300.1 AF298547.1 AF310106.1 AF464764.1 AK000517.1 AK000784.1 AK025952.1 AK223253.1 
    AK223269.1 AK292681.1 AK302989.1 BC001039.2 BC003592.1 

    10 DOTS entries:

    DT.86847106  DT.100760452  DT.95161138  DT.95144224  DT.97843016  DT.97843017  DT.121427228  DT.40283246 
    DT.92035922  DT.97779718 

    24/136 AceView cDNA sequences (see all 136):

    AI146844 AI655137 AW236554 BF445417 N41868 AW236428 AI637620 AK000784 
    AI638191 AF464764 AA743510 BF926652 BM758145 AW006249 AA301407 AW243537 
    AI968100 BE672098 AW014522 AL544013 BM783246 Z42234 BM783068 AI638784 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NLRP2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                                            -           -                                                                             -                     
    SP2:                                            -           -                                                                 -           -                     
    SP3:                                            -           -     -                                                           -           -                     
    SP4:                                            -           -           -     -     -                                         -           -                     
    SP5:        -     -     -     -     -           -           -                                                                                                   


    ECgene alternative splicing isoforms for NLRP2

    Expression
    for NLRP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NLRP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTCTGCCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NLRP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)

    See NLRP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NLRP2

    SOURCE GeneReport for Unigene cluster: Hs.369279

    UniProtKB/Swiss-Prot: NALP2_HUMAN, Q9NX02
    Tissue specificity: Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and
    brain

        SABiosciences Expression via Pathway-Focused PCR Array including NLRP2: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for NLRP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NLRP2 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia NLRP66
    --
    		 --
    		 30(a)
    23(a)
    		 1 ↔ many
    possible ortholog
    		 GL343482.1(99797-112078)
    GL343281.1(869690-874415)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-213a13.26
    si:ch211-213a13.56
    (see all 220)    		 si:ch211-213a13.5
    (see all 220)    		 7(a)
    7(a)
    (see all 220)    		 many ↔ many
    many ↔ many
    (see all 220)    		 22(8948738-8996350)
    22(9090823-9139153)


    ENSEMBL Gene Tree for NLRP2 (if available)
    TreeFam Gene Tree for NLRP2 (if available) 

    Paralogs
    for NLRP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NLRP2 gene
    NLRP132  NLRP42  NLRP92  NLRP62  NLRP32  NLRP142  NLRP72  NLRP112  
    NLRP102  NLRP52  NLRP12  NLRP82  NLRP122  
    14 SIMAP similar genes for NLRP2 using alignment to 10 protein entries:     NALP2_HUMAN (see all proteins):
    PP1579    PYDC2    NLRP7    NLRP1    CIAS1    NLRP14
    NLRP4    RNH1    NLRP13    NLRP8    NLRP9    NLRP12
    NLRP5    NLRP3

    NLRP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NLRP2
    PGOHUM00000241345


    Genomic Variants
    for NLRP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1251 NCBI SNPs in NLRP2 are shown (see all 1251)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1994757091,2
    		C,untested55485848(+) ATTTTC/TCCCCC 4 -- int10--------
    rs1994757141,2
    		C,untested55494119(+) GAGCCA/GATCTA 8 P syn10--------
    rs1384457771,2
    		C,Fother55481625(+) GCACCG/AAATGG 8 /Q /R mis12Minor allele frequency- A:0.00NA EU 5875
    rs1507172211,2
    		--55474704(+) AGACC-/CTGTCTC 1 -- us2k10--------
    rs1471883191,2
    		--55474734(+) GAAATA/GTAGAT 1 -- us2k10--------
    rs1911754401,2
    		--55474744(+) TGTACA/GTATAC 1 -- us2k10--------
    rs1829039471,2
    		--55474784(+) TGGGCA/GCGGTG 1 -- us2k10--------
    rs8135311,2
    		C,F,--55474828(+) CGAGGC/TGGGCG 4 -- us2k13Minor allele frequency- T:0.33NA 6
    rs1445338681,2
    		--55474854(+) AGTTTA/GAGACC 1 -- us2k10--------
    rs1474206711,2
    		--55474871(+) GCCAAA/CATAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NLRP2 (55464498 - 55512510 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for NLRP2
         2 CNVs: 67613 30928
    Human Gene Mutation Database (HGMD): NLRP2

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    Disorders / Diseases
    for NLRP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NLRP2 for disorders           About GeneDecksing

    OMIM gene information: 609364    OMIM disorders: --

    10 diseases for NLRP2:    About MalaCards
    beckwith-wiedemann syndrome    familial mediterranean fever    aggressive periodontitis    gonorrhea
    chronic lymphocytic leukemia    lymphocytic leukemia    crohn's disease    gingivitis
    periodontitis    leukemia

    Human Genome Epidemiology (HuGE) Navigator: NLRP2 (5 documents)

    Export disorders for NLRP2 gene to outside databases

    Publications
    for NLRP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NLRP2 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with NLRP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The PYRIN domain: a novel motif found in apoptosis and inflammation proteins. (PubMed id 11270363)1, 2, 3 Bertin J. and DiStefano P.S. (2000)
    2. PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages. (PubMed id 15456791)1, 2, 9 Bruey J.-M....Reed J.C. (2004)
    3. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. (PubMed id 15030775)1, 2 Agostini L....Tschopp J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. NALPs: a novel protein family involved in inflammation. (PubMed id 12563287)1, 3 Tschopp J....Burns K. (2003)
    7. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. (PubMed id 12019269)1, 2 Wang L.... Bertin J. (2002)
    8. The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. (PubMed id 11250163)1, 2 Martinon F.... Tschopp J. (2001)
    9. Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. (PubMed id 19103770)1, 9 Ji S....Choi Y. (2009)
    10. PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion. (PubMed id 15817483)1, 9 Kinoshita T.... Suda T. (2005)

    External Searches for NLRP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing NLRP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55655 HGNC: 22948 AceView: NALP2 Ensembl:ENSG00000022556 euGenes: HUgn55655
    ECgene: NLRP2 H-InvDB: NLRP2

    Other Databases showing NLRP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NLRP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NLRP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NLRP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NLRP2 gene:
    Search GeneIP for patents involving NLRP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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