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Aliases for NLRP2 Gene

Aliases for NLRP2 Gene

  • NLR Family, Pyrin Domain Containing 2 2 3
  • PYPAF2 3 4 6
  • NALP2 3 4 6
  • PAN1 3 4 6
  • PYRIN Domain And NACHT Domain-Containing Protein 1 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 2 2 3
  • PYRIN-Containing APAF1-Like Protein 2 3 4
  • Nucleotide-Binding Site Protein 1 3 4
  • NBS1 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 2 3
  • Leucine Rich Repeat And Pyrin Domain Containing 2 2
  • NACHT, LRR And PYD Domains-Containing Protein 2 3
  • Nucleotide-Binding Oligomerization Domain 2
  • NACHT, LRR And PYD Containing Protein 2 3
  • CLR19.9 3

External Ids for NLRP2 Gene

Previous Symbols for NLRP2 Gene

  • NALP2

Summaries for NLRP2 Gene

Entrez Gene Summary for NLRP2 Gene

  • NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NLRP2 Gene

NLRP2 (NLR Family, Pyrin Domain Containing 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Chks in Checkpoint Regulation. GO annotations related to this gene include Pyrin domain binding. An important paralog of this gene is NLRC3.

UniProtKB/Swiss-Prot for NLRP2 Gene

  • Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.

Gene Wiki entry for NLRP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP2 Gene

Genomics for NLRP2 Gene

Genomic Location for NLRP2 Gene

Start:
54,953,130 bp from pter
End:
55,001,142 bp from pter
Size:
48,013 bases
Orientation:
Plus strand

Genomic View for NLRP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP2 Gene

Regulatory Elements for NLRP2 Gene

Proteins for NLRP2 Gene

  • Protein details for NLRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX02-NALP2_HUMAN
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 2
    Protein Accession:
    Q9NX02
    Secondary Accessions:
    • B4DZL7
    • I3L0G4
    • Q53FL5
    • Q59G09
    • Q8IXT0
    • Q9BVN5
    • Q9H6G6
    • Q9HAV9
    • Q9NWK3

    Protein attributes for NLRP2 Gene

    Size:
    1062 amino acids
    Molecular mass:
    120515 Da
    Quaternary structure:
    • Interacts with CHUK, IKBKB, IKBKG and MEFV, as well as with full-length PYCARD and with the DAPIN domain of NAPL1, but not the full-length protein.
    SequenceCaution:
    • Sequence=AAG15253.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91377.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92537.1; Type=Frameshift; Positions=769; Evidence={ECO:0000305}; Sequence=BAD92537.1; Type=Miscellaneous discrepancy; Note=Erroneous prediction of the initiator methionine.; Evidence={ECO:0000305};

    Alternative splice isoforms for NLRP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NLRP2 Gene

Proteomics data for NLRP2 Gene at MOPED

Post-translational modifications for NLRP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NLRP2 Gene

Domains for NLRP2 Gene

Gene Families for NLRP2 Gene

HGNC:
  • NLR :Nucleotide-binding domain and leucine rich repeat containing
IUPHAR :

Suggested Antigen Peptide Sequences for NLRP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NX02

UniProtKB/Swiss-Prot:

NALP2_HUMAN
Domain:
  • The DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD:
    • Q9NX02
  • When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding:
    • Q9NX02
  • Contains 1 DAPIN domain.:
    • Q9NX02
  • Contains 1 NACHT domain.:
    • Q9NX02
Family:
  • Belongs to the NLRP family.:
    • Q9NX02
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.:
    • Q9NX02
genes like me logo Genes that share domains with NLRP2: view

Function for NLRP2 Gene

Molecular function for NLRP2 Gene

UniProtKB/Swiss-Prot Function: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
UniProtKB/Swiss-Prot Induction: By interferons and bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for NLRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15030775
GO:0005524 ATP binding IEA --
GO:0032090 Pyrin domain binding IPI 15030775
genes like me logo Genes that share ontologies with NLRP2: view

miRNA for NLRP2 Gene

miRTarBase miRNAs that target NLRP2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NLRP2 Gene

Localization for NLRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLRP2 Gene COMPARTMENTS Subcellular localization image for NLRP2 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NLRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15030775
genes like me logo Genes that share ontologies with NLRP2: view

Pathways for NLRP2 Gene

genes like me logo Genes that share pathways with NLRP2: view

Pathways by source for NLRP2 Gene

Gene Ontology (GO) - Biological Process for NLRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 15030775
GO:0050718 positive regulation of interleukin-1 beta secretion IDA 15030775
genes like me logo Genes that share ontologies with NLRP2: view

Transcripts for NLRP2 Gene

Unigene Clusters for NLRP2 Gene

NLR family, pyrin domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: -
SP7: - - - - - -
SP8: - - -
SP9:
SP10:

Relevant External Links for NLRP2 Gene

GeneLoc Exon Structure for
NLRP2
ECgene alternative splicing isoforms for
NLRP2

Expression for NLRP2 Gene

mRNA expression in normal human tissues for NLRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP2 Gene

This gene is overexpressed in Testis (5.9) and Esophagus - Mucosa (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NLRP2 Gene

SOURCE GeneReport for Unigene cluster for NLRP2 Gene Hs.369279

mRNA Expression by UniProt/SwissProt for NLRP2 Gene

Q9NX02-NALP2_HUMAN
Tissue specificity: Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.
genes like me logo Genes that share expressions with NLRP2: view

Orthologs for NLRP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRP2 35
  • 98.84 (n)
  • 98.59 (a)
NLRP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
NLRP2 35
  • 73.83 (n)
  • 63.79 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
OneToMany
NLRP2 35
  • 72.33 (n)
  • 59.69 (a)
mouse
(Mus musculus)
Mammalia Nlrp2 35
  • 60.38 (n)
  • 45.63 (a)
Nlrp2 16
Nlrp2 36
  • 44 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC684545 35
  • 60.89 (n)
  • 46.12 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
OneToMany
Species with no ortholog for NLRP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP2 Gene

ENSEMBL:
Gene Tree for NLRP2 (if available)
TreeFam:
Gene Tree for NLRP2 (if available)

Paralogs for NLRP2 Gene

Pseudogenes.org Pseudogenes for NLRP2 Gene

genes like me logo Genes that share paralogs with NLRP2: view

Variants for NLRP2 Gene

Sequence variations from dbSNP and Humsavar for NLRP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs12768 -- 55,000,769(-) TCATC(G/T)ATTTT synonymous-codon, reference
rs172006 -- 54,973,191(+) ctcaa(A/G)aaaaa intron-variant
rs269906 -- 54,967,411(+) cggga(A/G)gcgga intron-variant
rs269907 -- 54,968,024(+) agcaa(C/T)tctcg intron-variant
rs269908 -- 54,968,101(+) ttagt(C/T)gatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLRP2 Gene

Variant ID Type Subtype PubMed ID
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
nsv833880 CNV Loss 17160897
nsv912444 CNV Gain 21882294
nsv9767 CNV Gain 18304495
esv25586 CNV Gain 19812545
nsv821136 CNV Deletion 20802225
nsv512596 CNV Loss 21212237
esv2656929 CNV Deletion 23128226
esv2718934 CNV Deletion 23290073
esv2718935 CNV Deletion 23290073
esv2659880 CNV Deletion 23128226
esv2674256 CNV Deletion 23128226

Relevant External Links for NLRP2 Gene

HapMap Linkage Disequilibrium report
NLRP2
Human Gene Mutation Database (HGMD)
NLRP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP2 Gene

Disorders for NLRP2 Gene

Relevant External Links for NLRP2

Genetic Association Database (GAD)
NLRP2
Human Genome Epidemiology (HuGE) Navigator
NLRP2
genes like me logo Genes that share disorders with NLRP2: view

No data available for UniProtKB/Swiss-Prot for NLRP2 Gene

Publications for NLRP2 Gene

  1. PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages. (PMID: 15456791) Bruey J.-M. … Reed J.C. (J. Biol. Chem. 2004) 3 4 23
  2. The PYRIN domain: a novel motif found in apoptosis and inflammation proteins. (PMID: 11270363) Bertin J. … DiStefano P.S. (Cell Death Differ. 2000) 2 3 4
  3. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. (PMID: 12019269) Wang L. … Bertin J. (J. Biol. Chem. 2002) 3 4
  4. Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation. (PMID: 18772453) Granell M. … MonzA^ M. (Blood 2008) 3 48
  5. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PMID: 19074885) Enjuanes A. … Campo E. (Cancer Res. 2008) 3 48

Products for NLRP2 Gene

Sources for NLRP2 Gene

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