NLRP14 Gene

Aliases
for NLRP14 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifer: GC11P006700

Summaries
for NLRP14 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for NLRP14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000011.9  NT_009237.19  NC_018922.2  

SwitchGear Promoter luciferase reporter plasmid: NLRP14 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NLRP14

NLRP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P007017:  view genomic region     (about GC identifiers)

Proteins
for NLRP14 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for NLRP14: NX_Q86W24

Explore proteomics data for NLRP14 at MOPED


See NLRP14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

NLRP14 Human Recombinant Protein Products:

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	antibodies-online peptides for NLRP14

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NLRP14 Assay Products:

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	antibodies-online kits for NLRP14 (4 products)

Domains /
Families
for NLRP14 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q86W24

Find genes that share domains with NLRP14           About GenesLikeMe

Function
for NLRP14 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for NLRP14

miRNA Products:		miRTarBase miRNAs that target NLRP14: hsa-mir-335-5p (MIRT018844)
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		1 qRT-PCR Assays for microRNA that regulate NLRP14:
		hsa-miR-579
		SwitchGear 3'UTR luciferase reporter plasmid: NLRP14 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NLRP14
		Predesigned siRNA for gene silencing in human, mouse, rat NLRP14

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for NLRP14

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NLRP14
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRP14

Localization
for NLRP14 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Pathways & Interactions
for NLRP14 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for NLRP14 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for NLRP14 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for NLRP14 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NLRP14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTGTCTGGAT

About this image

Ovary (Reproductive System)
Secondary follicles
Testis (Reproductive System)

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for NLRP14
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NLRP14
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		QuantiFast Probe-based Assays in human, mouse, rat NLRP14

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRP14

Orthologs
for NLRP14 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for NLRP14 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for NLRP14 gene

NLRP4²  NLRP13²  NLRP9²  NLRC3²  NLRP6²  NLRP3²  NLRP7²  NLRP11²  

NLRP10²  NLRP2²  NLRP5²  NLRP8²  NLRP12²  

12 SIMAP similar genes for NLRP14 using alignment to 1 protein entry:     NAL14_HUMAN:

NLRP4    NLRP8    RNH1    NLRP7    NLRP13    NLRP3

NLRP5    NLRP9    NLRP12    NLRP1    NLRP2    NLRP11

Find genes that share paralogs with NLRP14           About GenesLikeMe

Genomic Variants
for NLRP14 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NLRP14 (see all 1239)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
VAR_0363874		A breast cancer sample4	--	see VAR_036387	2	S C	mis4		0	--	--	--	--
rs1994758801,2	C	untested1	7060134(+)	CGGGGA/GCTAGG	1	--	int1		0	--	--	--	--
rs1994758841,2	C	untested1	7068006(+)	ATCAGC/GAATGA	2	A G	mis1		0	--	--	--	--
rs1994758891,2	C	untested1	7091590(+)	GACTGA/TTAAAA	2	I L	mis1		0	--	--	--	--
rs1994758901,2	C	untested1	7091711(+)	CTCAGC/GGGGAG	1	--	int1		0	--	--	--	--
rs346887101,2	C,F	--	6982562(+)	CTTTCG/CTTTTT	1	--	int1		2		NA	4
rs13885321,2	C,F,O	--	7043758(+)	TTAGGG/AGCCAA	1	--	int1		5		NA	262
rs1181385301,2	C,F	--	7043790(+)	TTTAAG/ACAGCC	1	--	int1		1		NA	120
rs23460051,2	H	--	7043840(+)	AATTCT/GTAAGA	1	--	int1		4		NS EA	420
rs107697541,2	C,F,A,H	--	7043918(+)	AGATCA/GGAGGA	1	--	int1		15		NA WA CSA EA	517

HapMap Linkage Disequilibrium report for NLRP14 (7041677 - 7092757 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for NLRP14:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2617222	CNV	Deletion	19546169
nsv832061	CNV	Loss	17160897

Human Gene Mutation Database (HGMD): NLRP14

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing NLRP14

DNA2.0 Custom Variant and Variant Library Synthesis for NLRP14

Disorders / Diseases
for NLRP14 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for NLRP14 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. NALPs: a novel protein family involved in inflammation. (PubMed id 12563287)^{1, 2, 3} Tschopp J.... Burns K. (Nat. Rev. Mol. Cell Biol. 2003)
2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
3. The genetics of NOD-like receptors in Crohn's disease. (PubMed id 20403135)^{1, 4} Cummings J.R....Jewell D.P. (Tissue Antigens 2010)
4. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)^{1, 4} Enjuanes A....Campo E. (Cancer Res. 2008)
5. Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. (PubMed id 16931801)^{1, 2} Westerveld G.H.... Lombardi M.P. (Hum. Reprod. 2006)
6. NODs: intracellular proteins involved in inflammation and apoptosis. (PubMed id 12766759)^{1, 2} Inohara N. and Nunez G. (Nat. Rev. Immunol. 2003)
7. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (Science 2006)
8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)

External Searches for NLRP14 gene

Genome Databases showing NLRP14 gene

Other Databases showing NLRP14 gene

Specialized Databases showing NLRP14 gene

Products
for NLRP14 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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