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Aliases for NLRP14 Gene

Aliases for NLRP14 Gene

  • NLR Family, Pyrin Domain Containing 14 2 3
  • Nucleotide-Binding Oligomerization Domain Protein 5 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 14 2 3
  • NALP14 3 4
  • NOD5 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 14 3
  • Leucine Rich Repeat And Pyrin Domain Containing 14 2
  • Nucleotide-Binding Oligomerization Domain 2
  • NACHT, LRR And PYD Containing Protein 14 3
  • CLR11.2 3
  • GC-LRR 3
  • PAN8 3

External Ids for NLRP14 Gene

Previous HGNC Symbols for NLRP14 Gene

  • NALP14

Previous GeneCards Identifiers for NLRP14 Gene

  • GC11P006700

Summaries for NLRP14 Gene

Entrez Gene Summary for NLRP14 Gene

  • The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]

GeneCards Summary for NLRP14 Gene

NLRP14 (NLR Family, Pyrin Domain Containing 14) is a Protein Coding gene. An important paralog of this gene is NLRC3.

UniProtKB/Swiss-Prot for NLRP14 Gene

  • May be involved in inflammation and spermatogenesis

Gene Wiki entry for NLRP14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP14 Gene

Genomics for NLRP14 Gene

Regulatory Elements for NLRP14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NLRP14 Gene

7,020,446 bp from pter
7,089,025 bp from pter
68,580 bases
Plus strand

Genomic View for NLRP14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLRP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP14 Gene

Proteins for NLRP14 Gene

  • Protein details for NLRP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 14
    Protein Accession:
    Secondary Accessions:
    • Q7RTR6

    Protein attributes for NLRP14 Gene

    1093 amino acids
    Molecular mass:
    124733 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NLRP14 Gene

neXtProt entry for NLRP14 Gene

Proteomics data for NLRP14 Gene at MOPED

Post-translational modifications for NLRP14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NLRP14 Gene

Domains & Families for NLRP14 Gene

Gene Families for NLRP14 Gene

Protein Domains for NLRP14 Gene

Suggested Antigen Peptide Sequences for NLRP14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DAPIN domain.
  • Belongs to the NLRP family.
  • Contains 11 LRR (leucine-rich) repeats.
  • Contains 1 DAPIN domain.
  • Contains 1 NACHT domain.
  • Belongs to the NLRP family.
  • Contains 11 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRP14: view

Function for NLRP14 Gene

Molecular function for NLRP14 Gene

UniProtKB/Swiss-Prot Function:
May be involved in inflammation and spermatogenesis

Gene Ontology (GO) - Molecular Function for NLRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRP14: view
genes like me logo Genes that share phenotypes with NLRP14: view

Animal Model Products

miRNA for NLRP14 Gene

miRTarBase miRNAs that target NLRP14

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NLRP14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NLRP14 Gene

Localization for NLRP14 Gene

Subcellular locations from

Jensen Localization Image for NLRP14 Gene COMPARTMENTS Subcellular localization image for NLRP14 gene
Compartment Confidence
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NLRP14 Gene

Pathways & Interactions for NLRP14 Gene

SuperPathways for NLRP14 Gene

No Data Available

Interacting Proteins for NLRP14 Gene

Gene Ontology (GO) - Biological Process for NLRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IMP 16931801
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with NLRP14: view

No data available for Pathways by source and SIGNOR curated interactions for NLRP14 Gene

Drugs & Compounds for NLRP14 Gene

No Compound Related Data Available

Transcripts for NLRP14 Gene

mRNA/cDNA for NLRP14 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NLRP14 Gene

NLR family, pyrin domain containing 14:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NLRP14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP14 Gene

No ASD Table

Relevant External Links for NLRP14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLRP14 Gene

mRNA expression in normal human tissues for NLRP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP14 Gene

This gene is overexpressed in Testis (x9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NLRP14 Gene

SOURCE GeneReport for Unigene cluster for NLRP14 Gene Hs.449637

mRNA Expression by UniProt/SwissProt for NLRP14 Gene

Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with NLRP14: view

Protein tissue co-expression partners for NLRP14 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues for NLRP14 Gene

Orthologs for NLRP14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NLRP14 35
  • 83.21 (n)
  • 74.21 (a)
NLRP14 36
  • 74 (a)
(Canis familiaris)
Mammalia NLRP14 35
  • 83.76 (n)
  • 77.61 (a)
NLRP14 36
  • 77 (a)
(Mus musculus)
Mammalia Nlrp14 35
  • 70.54 (n)
  • 56.84 (a)
Nlrp14 16
Nlrp14 36
  • 56 (a)
(Pan troglodytes)
Mammalia NLRP14 35
  • 99.09 (n)
  • 98.54 (a)
NLRP14 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nlrp14 35
  • 68 (n)
  • 54.11 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
Species with no ortholog for NLRP14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP14 Gene

Gene Tree for NLRP14 (if available)
Gene Tree for NLRP14 (if available)

Paralogs for NLRP14 Gene

Paralogs for NLRP14 Gene

(12) SIMAP similar genes for NLRP14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NLRP14: view

Variants for NLRP14 Gene

Sequence variations from dbSNP and Humsavar for NLRP14 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs721322 -- 7,035,606(-) GTCGC(A/T)CTAAT intron-variant
rs879462 -- 7,073,421(-) aaaaa(C/T)ccaca intron-variant
rs879463 -- 7,072,241(+) GCCAG(A/G)TTGCT intron-variant, downstream-variant-500B
rs879464 -- 7,072,613(+) gcctg(C/T)cacca intron-variant, downstream-variant-500B
rs902732 -- 7,028,631(+) GCTCT(A/G)CATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLRP14 Gene

Variant ID Type Subtype PubMed ID
nsv832061 CNV Loss 17160897
esv2617222 CNV Deletion 19546169

Variation tolerance for NLRP14 Gene

Residual Variation Intolerance Score: 97.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.94; 89.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NLRP14 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP14 Gene

Disorders for NLRP14 Gene

Relevant External Links for NLRP14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NLRP14: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP14 Gene

Publications for NLRP14 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization. (PMID: 25403012) Huber R.G. … Fuchs J.E. (Protein Sci. 2015) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings J.R. … Jewell D.P. (Tissue Antigens 2010) 67

Products for NLRP14 Gene

Sources for NLRP14 Gene

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