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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NLRP14 Gene

protein-coding   GIFtS: 50
GCID: GC11P007017

NLR family, pyrin domain containing 14

(Previous names: NACHT, leucine rich repeat and PYD containing 14 )
(Previous symbol: NALP14)
 Explore 5 diseases affiliated with
NLRP14 via our new
 Human Malady Compendium 
Biological research products
for NLRP14
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
NLR Family, Pyrin Domain Containing 141 2     NACHT, Leucine Rich Repeat And PYD Containing 141 2
NALP141 2 3 5     Nucleotide-Binding Oligomerization Domain Protein 52 3
NOD51 2 3 5     Nalp-Iota1
CLR11.21 2     NACHT, LRR And PYD Containing Protein 142
GC-LRR1 2     NACHT, LRR And PYD Domains-Containing Protein 142
PAN81 2     Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain
Containing 142

External Ids:    HGNC: 229391   Entrez Gene: 3383232   Ensembl: ENSG000001580777   OMIM: 6096655   UniProtKB: Q86W243   

Export aliases for NLRP14 gene to outside databases

Previous GC identifer: GC11P006700


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NLRP14:
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically
contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an
N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family
members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory
caspases, caspase-1 and caspase-5. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NAL14_HUMAN, Q86W24
Function: May be involved in inflammation and spermatogenesis

Gene Wiki entry for NLRP14


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NLRP14 gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLRP14 promoter sequence
   Search SABiosciences Chromatin IP Primers for NLRP14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLRP14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

NLRP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLRP14 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P007017:  view genomic region     (about GC identifiers)

Start:
7,041,677 bp from pter      End:
7,092,757 bp from pter
Size:
51,081 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NAL14_HUMAN, Q86W24 (See protein sequence)
Recommended Name: NACHT, LRR and PYD domains-containing protein 14  
Size: 1093 amino acids; 124733 Da
Developmental stage: In the testis, expressed mainly in A dark spermatogonia, mid and late spermatocytes and spermatids
but not in mitotically active A pale and B spermatogonia
Secondary accessions: Q7RTR6

Explore the universe of human proteins at neXtProt for NLRP14: NX_Q86W24

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86W24

  • NLRP14 Protein expression data from MOPED and PaxDb:    About this image 
    NLRP14 Protein Expression
    REFSEQ proteins: NP_789792.1  
    ENSEMBL proteins: 
     ENSP00000299481  

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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NLRP14 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR007111 NACHT_NTPase
     IPR004020 DAPIN
     IPR011029 DEATH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q86W24

    ProtoNet protein and cluster: Q86W24

    1 Blocks protein family: IPB004020 Pyrin domain

    UniProtKB/Swiss-Prot: NAL14_HUMAN, Q86W24
    Similarity: Belongs to the NLRP family
    Similarity: Contains 1 DAPIN domain
    Similarity: Contains 11 LRR (leucine-rich) repeats
    Similarity: Contains 1 NACHT domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAL14_HUMAN, Q86W24
    Function: May be involved in inflammation and spermatogenesis

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
         
    NLRP14 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NLRP14:
     Decreased viability after Chla 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NLRP14

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IMP16931801
    GO:0030154cell differentiation IEA--

    NLRP14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NLRP14
    Search CenterWatch for drugs/clinical trials and news about NLRP14 / NAL14 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NLRP14 gene: 
    NM_176822.3  

    Unigene Cluster for NLRP14:

    NLR family, pyrin domain containing 14
    Hs.449637  [show with all ESTs]
    Unigene Representative Sequence: AK310900
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000299481(uc001mfb.1)

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    hsa-miR-579
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK310900.1 AY154469.1 

    1 DOTS entry:

    DT.40203418 

    4 AceView cDNA sequences:

    NM_176822 AY154469 BK001107 C15474 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NLRP14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTCTGGAT
    NLRP14 Expression
    About this image

    NLRP14 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Secondary follicles (Primary Cell)Ovary, Reproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NLRP14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NLRP14

    SOURCE GeneReport for Unigene cluster: Hs.449637

    UniProtKB/Swiss-Prot: NAL14_HUMAN, Q86W24
    Tissue specificity: Testis-specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRP14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NLRP14 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia NLRP66
    --
    --
    30(a)
    24(a)
    1 ↔ many
    possible ortholog
    GL343482.1(99797-112078)
    GL343281.1(869690-874415)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-213a13.26
    si:ch211-213a13.56
    (see all 220)
    si:ch211-213a13.5
    (see all 220)
    7(a)
    7(a)
    (see all 220)
    many ↔ many
    many ↔ many
    (see all 220)
    22(8948738-8996350)
    22(9090823-9139153)


    ENSEMBL Gene Tree for NLRP14 (if available)
    TreeFam Gene Tree for NLRP14 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NLRP14 gene
    NLRP132  NLRP42  NLRP92  NLRP62  NLRP32  NLRP72  NLRP112  NLRP102  
    NLRP22  NLRP52  NLRP12  NLRP82  NLRP122  
    12 SIMAP similar genes for NLRP14 using alignment to 1 protein entry:     NAL14_HUMAN:
    NLRP4    NLRP8    RNH1    NLRP7    NLRP13    NLRP5
    NLRP9    NLRP12    NLRP3    NLRP1    NLRP2    NLRP11

    NLRP14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1012 NCBI SNPs in NLRP14 are shown (see all 1012    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1994758891,2
    Cuntested7091590(+) GACTGA/TTAAAA 2 I L mis10--------
    rs1994758901,2
    Cuntested7091711(+) CTCAGC/GGGGAG 1 -- int10--------
    rs13885321,2
    C,O--7043758(+) TTAGGG/AGCCAA 1 -- int15Minor allele frequency- A:0.01NA 262
    rs1181385301,2
    F--7043790(+) TTTAAG/ACAGCC 1 -- int11Minor allele frequency- A:0.02NA 120
    rs23460051,2
    H--7043840(+) AATTCT/GTAAGA 1 -- int14Minor allele frequency- G:0.00NS EA 420
    rs107697541,2
    C,F,A,H--7043918(+) AGATCA/GGAGGA 1 -- int115Minor allele frequency- G:0.43NA WA CSA EA 517
    rs107697551,2
    C,F,A,H--7043949(+) ACCCAC/TCAAGG 1 -- int115Minor allele frequency- T:0.42NA WA CSA EA 518
    rs798622131,2
    F--7044031(+) TATAGC/TTGCAA 1 -- int11Minor allele frequency- T:0.09WA 118
    rs1927448051,2
    --7044070(+) CTGGAC/TTGTTA 1 -- int10--------
    rs788833511,2
    F--7044206(+) GAAAGA/GCAATA 1 -- int11Minor allele frequency- G:0.12EA 120

    HapMap Linkage Disequilibrium report for NLRP14 (7041677 - 7092757 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NLRP14
         1 CNV: 101122
    Human Gene Mutation Database (HGMD): NLRP14

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for NLRP14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NLRP14 for disorders           About GeneDecksing

    OMIM gene information: 609665    OMIM disorders: --

    5 diseases for NLRP14:    About MalaCards
    chronic lymphocytic leukemia    lymphocytic leukemia    crohn's disease    leukemia
    spermatogenic failure

    Human Genome Epidemiology (HuGE) Navigator: NLRP14 (3 documents)

    Export disorders for NLRP14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NLRP14 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NLRP14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NALPs: a novel protein family involved in inflammation. (PubMed id 12563287)1, 2, 3 Tschopp J....Burns K. (2003)
    2. Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. (PubMed id 16931801)1, 2 Westerveld G.H.... Lombardi M.P. (2006)
    3. NODs: intracellular proteins involved in inflammation and apoptosis. (PubMed id 12766759)1, 2 Inohara N. and Nunez G. (2003)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. The genetics of NOD-like receptors in Crohn's disease . (PubMed id 20403135)1 Cummings J.R....Jewell D.P. (2010)
    6. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1 Enjuanes A....Campo E. (2008)
    7. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 338323 HGNC: 22939 AceView: NALP14 Ensembl:ENSG00000158077 euGenes: HUgn338323
    ECgene: NLRP14 H-InvDB: NLRP14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NLRP14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NLRP14 gene:
    Search GeneIP for patents involving NLRP14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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