Aliases for NLRP14 Gene
Aliases for NLRP14 Gene
External Ids for NLRP14 Gene
- HGNC: 22939
- Entrez Gene: 338323
- Ensembl: ENSG00000158077
- OMIM: 609665
- UniProtKB: Q86W24
Previous HGNC Symbols for NLRP14 Gene
- NALP14
Previous GeneCards Identifiers for NLRP14 Gene
- GC11P006700
Summaries for NLRP14 Gene
-
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]
GeneCards Summary for NLRP14 Gene
NLRP14 (NLR Family Pyrin Domain Containing 14) is a Protein Coding gene. An important paralog of this gene is NLRP5.
UniProtKB/Swiss-Prot for NLRP14 Gene
-
May be involved in inflammation and spermatogenesis.
Additional gene information for NLRP14 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP14 Gene
Genomics for NLRP14 Gene
GeneHancer (GH) Regulatory Elements for NLRP14 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11I007019 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 550.8 | -0.1 | -137 | 2.5 | PKNOX1 ZFP64 ARID4B SIN3A YY1 ETS1 ZNF143 SP3 RXRA SP5 | ZNF214 PIR41527 NLRP14 DNHD1 ENSG00000254641 C11orf42 CYB5R2 ARFIP2 GC11M006985 GC11P006959 | |
GH11I006991 | Enhancer | 0.8 | Ensembl ENCODE | 11.3 | -28.0 | -28041 | 2.5 | PKNOX1 ZNF792 ZIC2 ZNF843 ZNF335 PRDM6 ZFP3 ZXDB TRIM28 ZBTB20 | LOC102724711 ZNF214 NLRP14 GVINP1 ZNF215 GC11M006969 GC11P006959 GC11M006985 | |
GH11I007071 | Enhancer | 0.4 | ENCODE | 16.1 | +52.7 | 52743 | 3.3 | CBFA2T3 ZEB2 | NLRP14 ZNF214 OVCH2 OLFML1 GC11M006985 GC11P007052 GC11P007045 | |
GH11I007890 | Enhancer | 1.1 | FANTOM5 Ensembl ENCODE | 5 | +872.7 | 872650 | 5.8 | ELF3 CTCF PKNOX1 EBF1 BATF IRF4 RAD21 RFX5 POLR2A ZNF143 | PIR41542 OR10A3 NLRP14 OR10A6 PIR32361 LOC283299 |
- Top Transcription factor binding sites by QIAGEN in the NLRP14 gene promoter:
Regulatory Element Products
Genomic Locations for NLRP14 Gene
- chr11:7,020,446-7,089,025
- (GRCh38/hg38)
- Size:
- 68,580 bases
- Orientation:
- Plus strand
- chr11:7,041,677-7,092,757
- (GRCh37/hg19)
Genomic View for NLRP14 Gene
- Cytogenetic band:
-
- 11p15.4 by Ensembl
- 11p15.4 by Entrez Gene
- 11p15.4 by HGNC


RefSeq DNA sequence for NLRP14 Gene
Proteins for NLRP14 Gene
-
Protein details for NLRP14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86W24-NAL14_HUMAN
- Recommended name:
- NACHT, LRR and PYD domains-containing protein 14
- Protein Accession:
- Q86W24
- Q7RTR6
Protein attributes for NLRP14 Gene
- Size:
- 1093 amino acids
- Molecular mass:
- 124733 Da
- Quaternary structure:
- No Data Available
Protein Expression for NLRP14 Gene
Post-translational modifications for NLRP14 Gene
Other Protein References for NLRP14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Protein Products
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Assay Products
No data available for DME Specific Peptides for NLRP14 Gene
Domains & Families for NLRP14 Gene
Gene Families for NLRP14 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for NLRP14 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NLRP14 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86W24- Family:
-
- Belongs to the NLRP family.
Function for NLRP14 Gene
Molecular function for NLRP14 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in inflammation and spermatogenesis.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005524 | ATP binding | IEA | -- |
Phenotypes for NLRP14 Gene
- GenomeRNAi human phenotypes for NLRP14:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation
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-
-
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miRNA for NLRP14 Gene
- miRTarBase miRNAs that target NLRP14
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLRP14 Gene
Localization for NLRP14 Gene
- Cytosol (1)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NLRP14 Gene
Pathways & Interactions for NLRP14 Gene
Interacting Proteins for NLRP14 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007275 | multicellular organism development | IEA | -- |
GO:0007283 | spermatogenesis | IMP | 16931801 |
GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for NLRP14 Gene
Transcripts for NLRP14 Gene
mRNA/cDNA for NLRP14 Gene
- (2) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NLRP14 Gene
CRISPR Products
-
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-
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available NLRP14 gene related products
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- Applied Biological Materials Clones for NLRP14
-
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Expression for NLRP14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for NLRP14 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NLRP14 Gene
NURSA nuclear receptor signaling pathways regulating expression of NLRP14 Gene:
NLRP14SOURCE GeneReport for Unigene cluster for NLRP14 Gene:
Hs.449637mRNA Expression by UniProt/SwissProt for NLRP14 Gene:
Q86W24-NAL14_HUMANPrimer Products
-
OriGene qPCR primer pairs for NLRP14
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No data available for Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLRP14 Gene
Orthologs for NLRP14 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | NLRP14 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | NLRP14 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | NLRP14 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Nlrp14 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Nlrp14 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany |
- Species where no ortholog for NLRP14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for NLRP14 Gene
Paralogs for NLRP14 Gene
(12) SIMAP similar genes for NLRP14 Gene using alignment to 1 proteins:
Variants for NLRP14 Gene
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs76274604 | benign, not provided, not specified | 7,039,746(+) | A/T | coding_sequence_variant, stop_gained | |
VAR_036387 | A breast cancer sample | p.Ser779Cys | |||
rs199475880 | not-provided, not provided | 7,038,903(+) | G/A | intron_variant | |
rs199475881 | not-provided, not provided | 7,042,635(+) | C/A/T | coding_sequence_variant, synonymous_variant | |
rs199475882 | not-provided, not provided | 7,046,685(+) | C/G/T | coding_sequence_variant, missense_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2617222 | CNV | deletion | 19546169 |
nsv832061 | CNV | loss | 17160897 |
Additional Variant Information for NLRP14 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP14 Gene
Disorders for NLRP14 Gene
Additional Disease Information for NLRP14
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for NLRP14 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP14 Gene
Publications for NLRP14 Gene
- NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J … Burns K (Nature reviews. Molecular cell biology 2003) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings JR … Jewell DP (Tissue antigens 2010) 3 44 58
- Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PMID: 19074885) Enjuanes A … Campo E (Cancer research 2008) 3 44 58
- Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. (PMID: 16931801) Westerveld GH … Lombardi MP (Human reproduction (Oxford, England) 2006) 3 4 58
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 15 available NLRP14 Antibodies ranked by validation data
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Sources for NLRP14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (120) Genetics Home Reference
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew