NLRP14 Gene
protein-coding GIFtS : 50
GCID: GC11 P007017
NLR family, pyrin domain containing 14 (Previous names: NACHT, leucine rich repeat and PYD containing 14 ) (Previous symbol: NALP14 )
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Aliasesfor NLRP14 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases NLR Family, Pyrin Domain Containing 14 1 2 NACHT, Leucine Rich Repeat And PYD Containing 141 2 NALP141 2 3 5 Nucleotide-Binding Oligomerization Domain Protein 52 3 NOD51 2 3 5 Nalp-Iota1 CLR11.21 2 NACHT, LRR And PYD Containing Protein 142 GC-LRR1 2 NACHT, LRR And PYD Domains-Containing Protein 142 PAN81 2 Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin DomainContaining 142
Export aliases for NLRP14 gene to outside databases Previous GC identifer: GC11P006700
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Summariesfor NLRP14 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for NLRP14 : The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: NAL14_HUMAN, Q86W24 Function : May be involved in inflammation and spermatogenesisGene Wiki entry for NLRP14
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Genomic Viewsfor NLRP14 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_009237.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NLRP14 gene promoter: NRSF form 1 NRSF form 2 Other transcription factors Search SABiosciences Chromatin IP Primers for NLRP14 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NLRP14
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4 NLRP14 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P007017: view genomic region
(about GC identifiers )
Start:
7,041,677 bp from pter
End:
7,092,757 bp from pter
Size:
51,081 bases
Orientation:
plus strand
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Proteinsfor NLRP14 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: NAL14_HUMAN, Q86W24 (See
protein sequence )Recommended Name: NACHT, LRR and PYD domains-containing protein 14 Size : 1093 amino acids; 124733 Da
Developmental stage : In the testis, expressed mainly in A dark spermatogonia, mid and late spermatocytes and spermatidsbut not in mitotically active A pale and B spermatogonia
Secondary accessions : Q7RTR6Explore the universe of human proteins at neXtProt for NLRP14: NX_Q86W24 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q86W24 NLRP14 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_789792.1 ENSEMBL proteins: ENSP00000299481 Human Recombinant Protein Products for NLRP14: NLRP14 Antibody Products: Assay Products for NLRP14:
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Protein
Domains / Familiesfor NLRP14 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
NLRP14 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q86W24 ProtoNet protein and cluster: Q86W24
1 Blocks protein family : IPB004020 Pyrin domain UniProtKB/Swiss-Prot: NAL14_HUMAN, Q86W24 Similarity : Belongs to the NLRP familySimilarity : Contains 1 DAPIN domainSimilarity : Contains 11 LRR (leucine-rich) repeatsSimilarity : Contains 1 NACHT domain
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Functionfor NLRP14 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: NAL14_HUMAN, Q86W24 Function : May be involved in inflammation and spermatogenesis
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005524 ATP binding
IEA --
NLRP14 for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for NLRP14 :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NLRP14 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NLRP14OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NLRP14 (NM_176822 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NLRP14 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NLRP14
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRP14
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Pathways & Interactionsfor NLRP14 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NLRP14 Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
NLRP14 for ontologies About GeneDecksing
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Drugs & Compoundsfor NLRP14 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for NLRP14 Search CenterWatch for drugs/clinical trials and news about NLRP14 / NAL14
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Transcriptsfor NLRP14 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for NLRP14 gene: NM_176822.3 Unigene Cluster for NLRP14:
NLR family, pyrin domain containing 14 Hs.449637 [show with all ESTs ] Unigene Representative Sequence: AK310900 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000299481 (uc001mfb.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NLRP14 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NLRP14OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NLRP14 (NM_176822 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NLRP14 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NLRP14
Additional cDNA sequence: AK310900.1 AY154469.1
1 DOTS entry : DT.40203418
4 AceView cDNA sequences :
NM_176822 AY154469 BK001107 C15474 GeneLoc Exon Structure
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Expression for NLRP14 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section NLRP14 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTGTCTGGATAbout this image NLRP14 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category Secondary follicles (Primary Cell)Ovary, Reproductive System Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See NLRP14 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NLRP14 SOURCE GeneReport for Unigene cluster: Hs.449637 UniProtKB/Swiss-Prot: NAL14_HUMAN, Q86W24 Tissue specificity : Testis-specific SABiosciences Custom PCR Arrays for NLRP14 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NLRP14Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat NLRP14 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NLRP14 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NLRP14 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRP14
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Orthologsfor NLRP14 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for NLRP14 gene from 2/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for NLRP14 (if available)TreeFam Gene Tree for NLRP14 (if available)
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Paralogsfor NLRP14 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for NLRP14 gene NLRP13 2 NLRP4 2 NLRP9 2 NLRP6 2 NLRP3 2 NLRP7 2 NLRP11 2 NLRP10 2 NLRP2 2 NLRP5 2 NLRP1 2 NLRP8 2 NLRP12 2 12 SIMAP similar genes for NLRP14 using alignment to 1 protein entry: NAL14_HUMAN :NLRP4 NLRP8 RNH1 NLRP7 NLRP13 NLRP5 NLRP9 NLRP12 NLRP3 NLRP1 NLRP2 NLRP11
NLRP14 for paralogs About GeneDecksing
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Genomic Variantsfor NLRP14 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for NLRP14 (7041677 - 7092757 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for NLRP14 1 CNV : 101122 Human Gene Mutation Database (HGMD) : NLRP14 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NLRP14
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Disorders
/ Diseasesfor NLRP14 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
NLRP14 for disorders About GeneDecksing
OMIM gene information: 609665
OMIM disorders : --5 diseases for NLRP14 : About MalaCards chronic lymphocytic leukemia lymphocytic leukemia crohn's disease leukemia spermatogenic failure Human Genome Epidemiology (HuGE) Navigator: NLRP14 (3 documents) Export disorders for NLRP14 gene to outside databases
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Publicationsfor NLRP14 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for NLRP14 gene integrated from 9 sources : (articles sorted by number of sources associating them with NLRP14) Utopia : connect your pdf to the dynamic world of online information
NALPs: a novel protein family involved in inflammation. (PubMed id 12563287) 1 , 2 , 3 Tschopp J....Burns K. (2003) Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. (PubMed id 16931801) 1 , 2 Westerveld G.H.... Lombardi M.P. (2006) NODs: intracellular proteins involved in inflammation and apoptosis. (PubMed id 12766759) 1 , 2 Inohara N. and Nunez G. (2003) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) The genetics of NOD-like receptors in Crohn's disease . (PubMed id 20403135) 1 Cummings J.R....Jewell D.P. (2010) Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885) 1 Enjuanes A....Campo E. (2008) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 2 Sjoeblom T.... Velculescu V.E. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006)
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External Searches for NLRP14 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing NLRP14 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing NLRP14 gene
(According to HUGE )
About This Section --
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Specialized Databases showing NLRP14 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for NLRP14 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for NLRP14 gene: Search GeneIP for patents involving NLRP14 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor NLRP14 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for NLRP14 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for NLRP14 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NLRP14 OriGene Protein Over-expression Lysate for NLRP14 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for NLRP14 OriGene 3'-UTR Clone for NLRP14 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NLRP14 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NLRP14 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for NLRP14 OriGene Custom Protein Services for NLRP14 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NLRP14 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NLRP14 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NLRP14 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat NLRP14 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NLRP14 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NLRP14
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NLRP14 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRP14
ThermoFisher Antibodies for NLRP14
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NLRP14
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