Aliases for NLRP14 Gene
Aliases for NLRP14 Gene
- NLR Family, Pyrin Domain Containing 14 2 3 5
- Nucleotide-Binding Oligomerization Domain Protein 5 3 4
- NACHT, Leucine Rich Repeat And PYD Containing 14 2 3
- NALP14 3 4
- NOD5 3 4
- Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 14 3
- Leucine Rich Repeat And Pyrin Domain Containing 14 2
External Ids for NLRP14 Gene
- HGNC: 22939
- Entrez Gene: 338323
- Ensembl: ENSG00000158077
- OMIM: 609665
- UniProtKB: Q86W24
Previous HGNC Symbols for NLRP14 Gene
- NALP14
Previous GeneCards Identifiers for NLRP14 Gene
- GC11P006700
Summaries for NLRP14 Gene
-
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]
GeneCards Summary for NLRP14 Gene
NLRP14 (NLR Family, Pyrin Domain Containing 14) is a Protein Coding gene. An important paralog of this gene is NLRP7.
UniProtKB/Swiss-Prot for NLRP14 Gene
-
May be involved in inflammation and spermatogenesis.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP14 Gene
Genomics for NLRP14 Gene
Regulatory Elements for NLRP14 Gene
Enhancers for NLRP14 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around NLRP14 on UCSC Golden Path with GeneCards custom track
Promoters for NLRP14 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around NLRP14 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the NLRP14 gene promoter:
Regulatory Element Products
Genomic Location for NLRP14 Gene
- Chromosome:
- 11
- Start:
- 7,020,446 bp from pter
- End:
- 7,089,025 bp from pter
- Size:
- 68,580 bases
- Orientation:
- Plus strand
Genomic View for NLRP14 Gene
Genes around NLRP14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.4 by Ensembl
- 11p15.4 by Entrez Gene
- 11p15.4 by HGNC
NLRP14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NLRP14 Gene
Proteins for NLRP14 Gene
-
Protein details for NLRP14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86W24-NAL14_HUMAN
- Recommended name:
- NACHT, LRR and PYD domains-containing protein 14
- Protein Accession:
- Q86W24
- Q7RTR6
Protein attributes for NLRP14 Gene
- Size:
- 1093 amino acids
- Molecular mass:
- 124733 Da
- Quaternary structure:
- No Data Available
Protein Expression for NLRP14 Gene
Post-translational modifications for NLRP14 Gene
Other Protein References for NLRP14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for NLRP14
-
Custom Antibody ServicesOriGene Antibodies for NLRP14
- Novus Biologicals Antibodies for NLRP14
- Abcam antibodies for NLRP14
- Invitrogen Antibodies for NLRP14
- antibodies-online Antibodies for NLRP14: See all 14
- GeneTex NLRP14 antibody for NLRP14
-
Custom Antibody ServicesProSci Antibodies for NLRP14
-
Santa Cruz Biotechnology (SCBT) Antibodies for NLRP14
Protein Products
-
OriGene Purified Proteins for NLRP14
- Search Origene for MassSpec and Protein Over-expression Lysates for NLRP14
- Origene Custom Protein Services for NLRP14
- Search GeneTex for Proteins for NLRP14
Assay Products
No data available for DME Specific Peptides for NLRP14 Gene
Domains & Families for NLRP14 Gene
Gene Families for NLRP14 Gene
- HGNC:
- IUPHAR :
Protein Domains for NLRP14 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NLRP14 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86W24UniProtKB/Swiss-Prot:
NAL14_HUMAN :- Contains 1 NACHT domain.
- Belongs to the NLRP family.
- Contains 11 LRR (leucine-rich) repeats.
- Domain:
-
- Contains 1 NACHT domain.
- Contains 1 pyrin domain.
- Family:
-
- Belongs to the NLRP family.
- Similarity:
-
- Contains 11 LRR (leucine-rich) repeats.
Function for NLRP14 Gene
Molecular function for NLRP14 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in inflammation and spermatogenesis.
Phenotypes for NLRP14 Gene
- GenomeRNAi human phenotypes for NLRP14:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for NLRP14 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NLRP14 gene
- Search ViGene Biosciences for NLRP14
CRISPR Products
-
OriGene CRISPR knockouts for NLRP14
-
Santa Cruz Biotechnology (SCBT) CRISPR for NLRP14
- GenScript: Design CRISPR guide RNA sequences for NLRP14
miRNA for NLRP14 Gene
- miRTarBase miRNAs that target NLRP14
miRNA Products
- Search ViGene Biosciences for NLRP14
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for NLRP14
- Browse OriGene Inhibitory RNA Products For NLRP14
-
ViGene Biosciences ready-to-package AAV shRNAs for NLRP14 gene
Clone Products
- OriGene clones in human for NLRP14
- OriGene ORF clones in human,mouse for NLRP14
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for NLRP14 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NLRP14 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NLRP14 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLRP14 Gene
Localization for NLRP14 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NLRP14 Gene
Pathways & Interactions for NLRP14 Gene
More details on SuperPathways for NLRP14
No Data Available
Interacting Proteins for NLRP14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | IMP | 16931801 |
No data available for Pathways by source and SIGNOR curated interactions for NLRP14 Gene
Transcripts for NLRP14 Gene
mRNA/cDNA for NLRP14 Gene
- (3) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NLRP14 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NLRP14
-
Santa Cruz Biotechnology (SCBT) CRISPR for NLRP14
- GenScript: Design CRISPR guide RNA sequences for NLRP14
miRNA Products
- Search ViGene Biosciences for NLRP14
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for NLRP14
- Browse OriGene Inhibitory RNA Products For NLRP14
-
ViGene Biosciences ready-to-package AAV shRNAs for NLRP14 gene
Clone Products
- OriGene clones in human for NLRP14
- OriGene ORF clones in human,mouse for NLRP14
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for NLRP14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for NLRP14 Gene
This gene is overexpressed in Testis (x9.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NLRP14 Gene
SOURCE GeneReport for Unigene cluster for NLRP14 Gene Hs.449637
mRNA Expression by UniProt/SwissProt for NLRP14 Gene
Q86W24-NAL14_HUMAN
Tissue specificity:
Testis-specific.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for NLRP14
No data available for Protein differential expression in normal tissues for NLRP14 Gene
Orthologs for NLRP14 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | NLRP14 35 |
|
||
| NLRP14 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | NLRP14 35 |
|
||
| NLRP14 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Nlrp14 35 |
|
||
| Nlrp14 16 |
|
||||
| Nlrp14 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | NLRP14 35 |
|
||
| NLRP14 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Nlrp14 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
OneToMany |
- Species with no ortholog for NLRP14:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for NLRP14 Gene
Paralogs for NLRP14 Gene
(12) SIMAP similar genes for NLRP14 Gene using alignment to 1 proteins:
Variants for NLRP14 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10839708 | - | 7,057,807(+) | TGTGT(A/G)AGGCC | intron-variant, reference, missense | |
| rs12801277 | - | 7,038,729(+) | CTGGA(A/C)TGAAG | reference, missense | |
| VAR_031933 | - | ||||
| rs199735773 | - | 7,038,843(+) | GAAGG(A/T)TCTGT | reference, missense | |
| rs16921697 | - | 7,038,861(+) | AGCGA(A/G)AGAAG | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv832061 | CNV | Loss | 17160897 |
| esv2617222 | CNV | Deletion | 19546169 |
Residual Variation Intolerance Score:
97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.94;
89.87% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for NLRP14 Gene
- Human Gene Mutation Database (HGMD)
- NLRP14
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP14 Gene
Disorders for NLRP14 Gene
Relevant External Links for NLRP14
No disorders were found for NLRP14 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP14 Gene
Publications for NLRP14 Gene
- NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4 67
- Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization. (PMID: 25403012) Huber R.G. … Fuchs J.E. (Protein Sci. 2015) 3
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
- The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings J.R. … Jewell D.P. (Tissue Antigens 2010) 3
Products for NLRP14 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for NLRP14
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NLRP14
- Search Origene for MassSpec and Protein Over-expression Lysates for NLRP14
- Origene Custom Protein Services for NLRP14
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for NLRP14
- Browse OriGene Inhibitory RNA Products For NLRP14
- OriGene qPCR primer pairs for NLRP14
- OriGene CRISPR knockouts for NLRP14
- OriGene clones in human for NLRP14
- OriGene ORF clones in human,mouse for NLRP14
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for NLRP14
- GenScript Custom Assay Services for NLRP14
- GenScript Custom overexpressing Cell Line Services for NLRP14
- GenScript: Design CRISPR guide RNA sequences for NLRP14
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NLRP14
- Novus Biologicals Antibodies for NLRP14
- Novus Biologicals proteins and lysates for NLRP14
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for NLRP14 gene
- ViGene Biosciences lentiviral particle packaged cDNA for NLRP14 gene
- ViGene Biosciences lentiviral particle packaged cDNA for NLRP14 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NLRP14 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NLRP14 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NLRP14 gene
- Search ViGene Biosciences for NLRP14
- Search ViGene Biosciences for NLRP14
- Santa Cruz Biotechnology (SCBT) Antibodies for NLRP14
- Search Santa Cruz Biotechnology (SCBT) for NLRP14 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NLRP14
- Custom Antibody ServicesProSci Antibodies for NLRP14
Sources for NLRP14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon