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Aliases for NLRP13 Gene

Aliases for NLRP13 Gene

  • NLR Family Pyrin Domain Containing 13 2 3 5
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 13 2 3
  • Nucleotide-Binding Oligomerization Domain Protein 14 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 13 2 3
  • NALP13 3 4
  • NOD14 3 4
  • NACHT, LRR And PYD Domains-Containing Protein 13 3
  • NACHT, LRR And PYD Containing Protein 13 3
  • CLR19.7 3
  • PAN13 3

External Ids for NLRP13 Gene

Previous HGNC Symbols for NLRP13 Gene

  • NALP13

Previous GeneCards Identifiers for NLRP13 Gene

  • GC19M061100
  • GC19M056407
  • GC19M052718

Summaries for NLRP13 Gene

Entrez Gene Summary for NLRP13 Gene

  • This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

GeneCards Summary for NLRP13 Gene

NLRP13 (NLR Family Pyrin Domain Containing 13) is a Protein Coding gene. An important paralog of this gene is NLRP14.

UniProtKB/Swiss-Prot for NLRP13 Gene

  • Involved in inflammation.

Gene Wiki entry for NLRP13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP13 Gene

Genomics for NLRP13 Gene

Regulatory Elements for NLRP13 Gene

Enhancers for NLRP13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F056293 0.8 FANTOM5 ENCODE 1.9 -363.0 -362963 2.7 ZNF316 MAFK ZBTB40 NLRP5 ZSCAN5A NLRP11 NLRP8 ZNF583 NLRP13 LOC105372470 ENSG00000267298
GH19F055857 0.8 ENCODE 0.2 +75.0 74987 0.2 CTCF HDAC1 ATF1 ZSCAN18 CREB3L1 ARID4B GLI4 ZNF2 YY1 ZNF324 NLRP11 NLRP13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NLRP13 on UCSC Golden Path with GeneCards custom track

Genomic Location for NLRP13 Gene

Chromosome:
19
Start:
55,891,692 bp from pter
End:
55,932,336 bp from pter
Size:
40,645 bases
Orientation:
Minus strand

Genomic View for NLRP13 Gene

Genes around NLRP13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP13 Gene

Proteins for NLRP13 Gene

  • Protein details for NLRP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W25-NAL13_HUMAN
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 13
    Protein Accession:
    Q86W25
    Secondary Accessions:
    • Q7RTR5

    Protein attributes for NLRP13 Gene

    Size:
    1043 amino acids
    Molecular mass:
    118884 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NLRP13 Gene

Post-translational modifications for NLRP13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NLRP13 Gene

Domains & Families for NLRP13 Gene

Gene Families for NLRP13 Gene

Protein Domains for NLRP13 Gene

Suggested Antigen Peptide Sequences for NLRP13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W25

UniProtKB/Swiss-Prot:

NAL13_HUMAN :
  • Contains 1 NACHT domain.
  • Belongs to the NLRP family.
  • Contains 7 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 NACHT domain.
  • Contains 1 pyrin domain.
Family:
  • Belongs to the NLRP family.
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRP13: view

Function for NLRP13 Gene

Molecular function for NLRP13 Gene

UniProtKB/Swiss-Prot Function:
Involved in inflammation.

Gene Ontology (GO) - Molecular Function for NLRP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRP13: view

Phenotypes for NLRP13 Gene

genes like me logo Genes that share phenotypes with NLRP13: view

Animal Model Products

miRNA for NLRP13 Gene

miRTarBase miRNAs that target NLRP13

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLRP13 Gene

Localization for NLRP13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NLRP13 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NLRP13 Gene

Pathways & Interactions for NLRP13 Gene

SuperPathways for NLRP13 Gene

No Data Available

Interacting Proteins for NLRP13 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343891%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000343891 Q86W25-NAL13_HUMAN for NLRP13 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NLRP13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NLRP13 Gene

Transcripts for NLRP13 Gene

mRNA/cDNA for NLRP13 Gene

(2) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP13 Gene

No ASD Table

Relevant External Links for NLRP13 Gene

GeneLoc Exon Structure for
NLRP13
ECgene alternative splicing isoforms for
NLRP13

Expression for NLRP13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NLRP13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP13 Gene

This gene is overexpressed in Breast - Mammary Tissue (x29.0), Ovary (x9.6), Testis (x5.6), and Prostate (x5.3).

Protein differential expression in normal tissues from HIPED for NLRP13 Gene

This gene is overexpressed in Colon (37.9) and Gallbladder (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NLRP13 Gene



NURSA nuclear receptor signaling pathways regulating expression of NLRP13 Gene:

NLRP13

SOURCE GeneReport for Unigene cluster for NLRP13 Gene:

Hs.446924
genes like me logo Genes that share expression patterns with NLRP13: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NLRP13 Gene

Orthologs for NLRP13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRP13 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia NLRP13 34 35
  • 74.8 (n)
cow
(Bos Taurus)
Mammalia NLRP13 34 35
  • 60.82 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 30 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 29 (a)
OneToMany
Species where no ortholog for NLRP13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP13 Gene

ENSEMBL:
Gene Tree for NLRP13 (if available)
TreeFam:
Gene Tree for NLRP13 (if available)

Paralogs for NLRP13 Gene

(11) SIMAP similar genes for NLRP13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NLRP13: view

Variants for NLRP13 Gene

Sequence variations from dbSNP and Humsavar for NLRP13 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs796052177 Likely benign 55,932,122(-) CTGCC(A/G)ACCCT reference, missense
rs199475874 untested 55,923,967(-) ACAGG(C/T)CCAGG reference, missense
rs199475875 untested 55,912,287(-) GAAGT(A/G)CCTTT reference, synonymous-codon
rs199475876 untested 55,911,780(-) CTAAA(G/T)CACTG reference, missense
rs199475877 untested 55,902,174(-) CCGCT(A/T)GCAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NLRP13 Gene

Variant ID Type Subtype PubMed ID
nsv580351 CNV gain 21841781
nsv510927 OTHER complex 20534489
nsv1138730 CNV deletion 24896259
nsv1110333 CNV duplication 24896259
nsv1067116 CNV gain 25217958
nsv1064105 CNV gain 25217958
nsv1057383 CNV gain 25217958
esv3644852 CNV gain 21293372
esv3644851 CNV gain 21293372
esv3644849 CNV gain 21293372
esv3575086 CNV gain 25503493
dgv6582n54 CNV gain 21841781
dgv3681n100 CNV gain 25217958
dgv3680n100 CNV gain 25217958

Variation tolerance for NLRP13 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NLRP13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NLRP13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP13 Gene

Disorders for NLRP13 Gene

Relevant External Links for NLRP13

Genetic Association Database (GAD)
NLRP13
Human Genome Epidemiology (HuGE) Navigator
NLRP13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NLRP13

No disorders were found for NLRP13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP13 Gene

Publications for NLRP13 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4 64
  2. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings J.R. … Jewell D.P. (Tissue Antigens 2010) 3 46 64
  3. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PMID: 19074885) Enjuanes A. … Campo E. (Cancer Res. 2008) 3 46 64
  4. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N. … Nunez G. (Nat. Rev. Immunol. 2003) 3 4 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for NLRP13 Gene

Sources for NLRP13 Gene

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