Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NLRP13 Gene

Aliases for NLRP13 Gene

  • NLR Family, Pyrin Domain Containing 13 2 3 5
  • Nucleotide-Binding Oligomerization Domain Protein 14 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 13 2 3
  • NALP13 3 4
  • NOD14 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 13 3
  • Leucine Rich Repeat And Pyrin Domain Containing 13 2
  • Nucleotide-Binding Oligomerization Domain 2
  • NACHT, LRR And PYD Containing Protein 13 3
  • CLR19.7 3
  • PAN13 3

External Ids for NLRP13 Gene

Previous HGNC Symbols for NLRP13 Gene

  • NALP13

Previous GeneCards Identifiers for NLRP13 Gene

  • GC19M061100
  • GC19M056407
  • GC19M052718

Summaries for NLRP13 Gene

Entrez Gene Summary for NLRP13 Gene

  • This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

GeneCards Summary for NLRP13 Gene

NLRP13 (NLR Family, Pyrin Domain Containing 13) is a Protein Coding gene. An important paralog of this gene is NLRP7.

UniProtKB/Swiss-Prot for NLRP13 Gene

  • Involved in inflammation.

Gene Wiki entry for NLRP13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP13 Gene

Genomics for NLRP13 Gene

Regulatory Elements for NLRP13 Gene

Enhancers for NLRP13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NLRP13 on UCSC Golden Path with GeneCards custom track

Genomic Location for NLRP13 Gene

Chromosome:
19
Start:
55,891,692 bp from pter
End:
55,932,336 bp from pter
Size:
40,645 bases
Orientation:
Minus strand

Genomic View for NLRP13 Gene

Genes around NLRP13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP13 Gene

Proteins for NLRP13 Gene

  • Protein details for NLRP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W25-NAL13_HUMAN
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 13
    Protein Accession:
    Q86W25
    Secondary Accessions:
    • Q7RTR5

    Protein attributes for NLRP13 Gene

    Size:
    1043 amino acids
    Molecular mass:
    118884 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NLRP13 Gene

Proteomics data for NLRP13 Gene at MOPED

Post-translational modifications for NLRP13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NLRP13 Gene

Domains & Families for NLRP13 Gene

Gene Families for NLRP13 Gene

Protein Domains for NLRP13 Gene

Suggested Antigen Peptide Sequences for NLRP13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W25

UniProtKB/Swiss-Prot:

NAL13_HUMAN :
  • Contains 1 NACHT domain.
  • Belongs to the NLRP family.
  • Contains 7 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 NACHT domain.
  • Contains 1 pyrin domain.
Family:
  • Belongs to the NLRP family.
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRP13: view

Function for NLRP13 Gene

Molecular function for NLRP13 Gene

UniProtKB/Swiss-Prot Function:
Involved in inflammation.

Phenotypes for NLRP13 Gene

genes like me logo Genes that share phenotypes with NLRP13: view

Animal Model Products

CRISPR Products

miRNA for NLRP13 Gene

miRTarBase miRNAs that target NLRP13

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLRP13 Gene

Localization for NLRP13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLRP13 Gene COMPARTMENTS Subcellular localization image for NLRP13 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NLRP13 Gene

Pathways & Interactions for NLRP13 Gene

SuperPathways for NLRP13 Gene

No Data Available

Interacting Proteins for NLRP13 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343891%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000343891 for NLRP13 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for NLRP13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NLRP13 Gene

Drugs & Compounds for NLRP13 Gene

No Compound Related Data Available

Transcripts for NLRP13 Gene

mRNA/cDNA for NLRP13 Gene

(3) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP13 Gene

No ASD Table

Relevant External Links for NLRP13 Gene

GeneLoc Exon Structure for
NLRP13
ECgene alternative splicing isoforms for
NLRP13

Expression for NLRP13 Gene

mRNA expression in normal human tissues for NLRP13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP13 Gene

This gene is overexpressed in Breast - Mammary Tissue (x29.0), Ovary (x9.6), Testis (x5.6), and Prostate (x5.3).

Protein differential expression in normal tissues from HIPED for NLRP13 Gene

This gene is overexpressed in Colon (37.9) and Gallbladder (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NLRP13 Gene



SOURCE GeneReport for Unigene cluster for NLRP13 Gene Hs.446924

genes like me logo Genes that share expression patterns with NLRP13: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NLRP13 Gene

Orthologs for NLRP13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NLRP13 35
  • 60.82 (n)
  • 50.05 (a)
NLRP13 36
  • 47 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NLRP13 35
  • 74.8 (n)
  • 61.58 (a)
NLRP13 36
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NLRP13 35
  • 99.49 (n)
  • 99.23 (a)
NLRP13 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
OneToMany
Species with no ortholog for NLRP13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP13 Gene

ENSEMBL:
Gene Tree for NLRP13 (if available)
TreeFam:
Gene Tree for NLRP13 (if available)

Paralogs for NLRP13 Gene

(11) SIMAP similar genes for NLRP13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NLRP13: view

Variants for NLRP13 Gene

Sequence variations from dbSNP and Humsavar for NLRP13 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs303997 - 55,913,077(+) TAGCC(C/T)GCATT reference, missense
rs17711239 - 55,907,897(+) TGCTG(C/T)TACCC reference, missense
rs7258847 -- 55,902,166(+) GACAA(A/G)TGCTT reference, synonymous-codon
rs7260642 -- 55,914,707(+) ATGAT(A/G)GAATT intron-variant
rs12979484 -- 55,914,091(+) GCTTA(A/C/G)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLRP13 Gene

Variant ID Type Subtype PubMed ID
nsv510927 CNV Complex 20534489
nsv912507 CNV Gain 21882294
nsv912508 CNV Gain 21882294

Variation tolerance for NLRP13 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NLRP13 Gene

Disorders for NLRP13 Gene

Relevant External Links for NLRP13

Genetic Association Database (GAD)
NLRP13
Human Genome Epidemiology (HuGE) Navigator
NLRP13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NLRP13

No disorders were found for NLRP13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP13 Gene

Publications for NLRP13 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 3
  4. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings J.R. … Jewell D.P. (Tissue Antigens 2010) 3
  5. The NLR gene family: a standard nomenclature. (PMID: 18341998) Ting J.P. … Ward P.A. (Immunity 2008) 3

Products for NLRP13 Gene

Sources for NLRP13 Gene

Content