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Aliases for NLRP13 Gene

Aliases for NLRP13 Gene

  • NLR Family, Pyrin Domain Containing 13 2 3
  • Nucleotide-Binding Oligomerization Domain Protein 14 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 13 2 3
  • NALP13 3 4
  • NOD14 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 13 3
  • Leucine Rich Repeat And Pyrin Domain Containing 13 2
  • Nucleotide-Binding Oligomerization Domain 2
  • NACHT, LRR And PYD Containing Protein 13 3
  • CLR19.7 3
  • PAN13 3

External Ids for NLRP13 Gene

Previous HGNC Symbols for NLRP13 Gene

  • NALP13

Previous GeneCards Identifiers for NLRP13 Gene

  • GC19M061100
  • GC19M056407
  • GC19M052718

Summaries for NLRP13 Gene

Entrez Gene Summary for NLRP13 Gene

  • NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP13, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NLRP13 Gene

NLRP13 (NLR Family, Pyrin Domain Containing 13) is a Protein Coding gene. An important paralog of this gene is NLRC3.

UniProtKB/Swiss-Prot for NLRP13 Gene

  • Involved in inflammation.

Gene Wiki entry for NLRP13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP13 Gene

Genomics for NLRP13 Gene

Genomic Location for NLRP13 Gene

55,891,692 bp from pter
55,932,336 bp from pter
40,645 bases
Minus strand

Genomic View for NLRP13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLRP13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP13 Gene

No data available for Regulatory Elements for NLRP13 Gene

Proteins for NLRP13 Gene

  • Protein details for NLRP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 13
    Protein Accession:
    Secondary Accessions:
    • Q7RTR5

    Protein attributes for NLRP13 Gene

    1043 amino acids
    Molecular mass:
    118884 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NLRP13 Gene

Proteomics data for NLRP13 Gene at MOPED

Post-translational modifications for NLRP13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NLRP13 Gene

Domains & Families for NLRP13 Gene

Gene Families for NLRP13 Gene

Protein Domains for NLRP13 Gene

Suggested Antigen Peptide Sequences for NLRP13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DAPIN domain.
  • Belongs to the NLRP family.
  • Contains 7 LRR (leucine-rich) repeats.
  • Contains 1 DAPIN domain.
  • Contains 1 NACHT domain.
  • Belongs to the NLRP family.
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRP13: view

Function for NLRP13 Gene

Molecular function for NLRP13 Gene

UniProtKB/Swiss-Prot Function:
Involved in inflammation.

Gene Ontology (GO) - Molecular Function for NLRP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRP13: view

Animal Model Products

CRISPR Products

miRNA for NLRP13 Gene

miRTarBase miRNAs that target NLRP13

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NLRP13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for NLRP13 Gene

Localization for NLRP13 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NLRP13 Gene

Pathways & Interactions for NLRP13 Gene

SuperPathways for NLRP13 Gene

No Data Available

Interacting Proteins for NLRP13 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000343891 for NLRP13 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for NLRP13 Gene


No data available for Pathways by source and SIGNOR curated interactions for NLRP13 Gene

Drugs & Compounds for NLRP13 Gene

No Compound Related Data Available

Transcripts for NLRP13 Gene

mRNA/cDNA for NLRP13 Gene

(2) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NLRP13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP13 Gene

No ASD Table

Relevant External Links for NLRP13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLRP13 Gene

mRNA expression in normal human tissues for NLRP13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP13 Gene

This gene is overexpressed in Breast - Mammary Tissue (x29.0), Ovary (x9.6), Testis (x5.6), and Prostate (x5.3).

Protein differential expression in normal tissues from HIPED for NLRP13 Gene

This gene is overexpressed in Colon (37.9) and Gallbladder (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NLRP13 Gene

SOURCE GeneReport for Unigene cluster for NLRP13 Gene Hs.446924

genes like me logo Genes that share expression patterns with NLRP13: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NLRP13 Gene

Orthologs for NLRP13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NLRP13 35
  • 60.82 (n)
  • 50.05 (a)
NLRP13 36
  • 47 (a)
(Canis familiaris)
Mammalia NLRP13 35
  • 74.8 (n)
  • 61.58 (a)
NLRP13 36
  • 54 (a)
(Pan troglodytes)
Mammalia NLRP13 35
  • 99.49 (n)
  • 99.23 (a)
NLRP13 36
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
Species with no ortholog for NLRP13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP13 Gene

Gene Tree for NLRP13 (if available)
Gene Tree for NLRP13 (if available)

Paralogs for NLRP13 Gene

Paralogs for NLRP13 Gene

(11) SIMAP similar genes for NLRP13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NLRP13: view

Variants for NLRP13 Gene

Sequence variations from dbSNP and Humsavar for NLRP13 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs160104 -- 55,921,837(-) tggct(G/T)ccagt intron-variant
rs169991 -- 55,896,499(+) cctgg(A/C)gacag intron-variant
rs215237 -- 55,893,337(+) gagcc(A/G)agatc intron-variant
rs302821 -- 55,892,562(+) gatta(C/T)aggcg intron-variant
rs302822 -- 55,893,247(+) gctgg(C/G)tgtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLRP13 Gene

Variant ID Type Subtype PubMed ID
nsv510927 CNV Complex 20534489
nsv912507 CNV Gain 21882294
nsv912508 CNV Gain 21882294

Variation tolerance for NLRP13 Gene

Residual Variation Intolerance Score: 89.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NLRP13 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP13 Gene

Disorders for NLRP13 Gene

Relevant External Links for NLRP13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NLRP13: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP13 Gene

Publications for NLRP13 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 67
  4. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings J.R. … Jewell D.P. (Tissue Antigens 2010) 67
  5. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PMID: 19875614) Paterson A.D. … Bull S.B. (Diabetes 2010) 67

Products for NLRP13 Gene

Sources for NLRP13 Gene

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