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Aliases for NLRP13 Gene

Aliases for NLRP13 Gene

  • NLR Family, Pyrin Domain Containing 13 2 3
  • NALP13 3 4 6
  • NOD14 3 4 6
  • Nucleotide-Binding Oligomerization Domain Protein 14 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 13 2 3
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 13 3
  • Leucine Rich Repeat And Pyrin Domain Containing 13 2
  • NACHT, LRR And PYD Domains-Containing Protein 13 3
  • Nucleotide-Binding Oligomerization Domain 2
  • NACHT, LRR And PYD Containing Protein 13 3
  • CLR19.7 3
  • PAN13 3

External Ids for NLRP13 Gene

Previous HGNC Symbols for NLRP13 Gene

  • NALP13

Previous GeneCards Identifiers for NLRP13 Gene

  • GC19M061100
  • GC19M056407
  • GC19M052718

Summaries for NLRP13 Gene

Entrez Gene Summary for NLRP13 Gene

  • NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP13, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NLRP13 Gene

NLRP13 (NLR Family, Pyrin Domain Containing 13) is a Protein Coding gene. An important paralog of this gene is NLRC3.

UniProtKB/Swiss-Prot for NLRP13 Gene

  • Involved in inflammation.

Gene Wiki entry for NLRP13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP13 Gene

Genomics for NLRP13 Gene

Genomic Location for NLRP13 Gene

Start:
55,891,692 bp from pter
End:
55,932,336 bp from pter
Size:
40,645 bases
Orientation:
Minus strand

Genomic View for NLRP13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLRP13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP13 Gene

No data available for Regulatory Elements for NLRP13 Gene

Proteins for NLRP13 Gene

  • Protein details for NLRP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W25-NAL13_HUMAN
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 13
    Protein Accession:
    Q86W25
    Secondary Accessions:
    • Q7RTR5

    Protein attributes for NLRP13 Gene

    Size:
    1043 amino acids
    Molecular mass:
    118884 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NLRP13 Gene

Proteomics data for NLRP13 Gene at MOPED

Post-translational modifications for NLRP13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NLRP13 Gene

Domains for NLRP13 Gene

Gene Families for NLRP13 Gene

HGNC:
  • NLR :Nucleotide-binding domain and leucine rich repeat containing
IUPHAR :

Protein Domains for NLRP13 Gene

Suggested Antigen Peptide Sequences for NLRP13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W25

UniProtKB/Swiss-Prot:

NAL13_HUMAN :
  • Q86W25
Domain:
  • Contains 1 DAPIN domain.
  • Contains 1 NACHT domain.
Family:
  • Belongs to the NLRP family.
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRP13: view

Function for NLRP13 Gene

Molecular function for NLRP13 Gene

UniProtKB/Swiss-Prot Function: Involved in inflammation.

Gene Ontology (GO) - Molecular Function for NLRP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRP13: view

miRNA for NLRP13 Gene

miRTarBase miRNAs that target NLRP13

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NLRP13 Gene

Localization for NLRP13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLRP13 Gene COMPARTMENTS Subcellular localization image for NLRP13 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NLRP13 Gene

Pathways for NLRP13 Gene

SuperPathways for NLRP13 Gene

No Data Available

Interacting Proteins for NLRP13 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343891%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000343891 for NLRP13 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for NLRP13 Gene

None

No data available for Pathways by source for NLRP13 Gene

Transcripts for NLRP13 Gene

mRNA/cDNA for NLRP13 Gene

(4) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP13 Gene

No ASD Table

Relevant External Links for NLRP13 Gene

GeneLoc Exon Structure for
NLRP13
ECgene alternative splicing isoforms for
NLRP13

Expression for NLRP13 Gene

mRNA expression in normal human tissues for NLRP13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP13 Gene

This gene is overexpressed in Breast - Mammary Tissue (29.0), Ovary (9.6), Testis (5.6), and Prostate (5.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NLRP13 Gene

SOURCE GeneReport for Unigene cluster for NLRP13 Gene Hs.446924

genes like me logo Genes that share expressions with NLRP13: view

No data available for mRNA Expression by UniProt/SwissProt for NLRP13 Gene

Orthologs for NLRP13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRP13 35
  • 99.49 (n)
  • 99.23 (a)
NLRP13 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NLRP13 35
  • 60.82 (n)
  • 50.05 (a)
NLRP13 36
  • 47 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NLRP13 35
  • 74.8 (n)
  • 61.58 (a)
NLRP13 36
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
OneToMany
Species with no ortholog for NLRP13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP13 Gene

ENSEMBL:
Gene Tree for NLRP13 (if available)
TreeFam:
Gene Tree for NLRP13 (if available)

Paralogs for NLRP13 Gene

Paralogs for NLRP13 Gene

Selected SIMAP similar genes for NLRP13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NLRP13: view

Variants for NLRP13 Gene

Sequence variations from dbSNP and Humsavar for NLRP13 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs160104 -- 55,921,837(-) tggct(G/T)ccagt intron-variant
rs169991 -- 55,896,499(+) cctgg(A/C)gacag intron-variant
rs215237 -- 55,893,337(+) gagcc(A/G)agatc intron-variant
rs302821 -- 55,892,562(+) gatta(C/T)aggcg intron-variant
rs302822 -- 55,893,247(+) gctgg(C/G)tgtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLRP13 Gene

Variant ID Type Subtype PubMed ID
nsv510927 CNV Complex 20534489
nsv912507 CNV Gain 21882294
nsv912508 CNV Gain 21882294

Relevant External Links for NLRP13 Gene

HapMap Linkage Disequilibrium report
NLRP13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP13 Gene

Disorders for NLRP13 Gene

Relevant External Links for NLRP13

Genetic Association Database (GAD)
NLRP13
Human Genome Epidemiology (HuGE) Navigator
NLRP13
genes like me logo Genes that share disorders with NLRP13: view

No data available for UniProtKB/Swiss-Prot for NLRP13 Gene

Publications for NLRP13 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4
  2. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N. … Nunez G. (Nat. Rev. Immunol. 2003) 3 4
  3. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PMID: 19074885) Enjuanes A. … Campo E. (Cancer Res. 2008) 3 48
  4. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings J.R. … Jewell D.P. (Tissue Antigens 2010) 3 48
  5. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 3

Products for NLRP13 Gene

Sources for NLRP13 Gene

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