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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NLRP12 Gene

protein-coding   GIFtS: 55
GCID: GC19M054296

NLR family, pyrin domain containing 12

(Previous names: NACHT, leucine rich repeat and PYD containing 12 )
(Previous symbol: NALP12)
 Explore 34 diseases affiliated with
NLRP12 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NLRP12    

Aliases
for NLRP12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NLR Family, Pyrin Domain Containing 121 2     PYRIN-Containing APAF1-Like Protein 72 3
NALP121 2 3 5     FCAS22 5
PYPAF71 2 3 5     Monarch11
RNO2 3 5     Monarch 12
CLR19.31 2     Monarch-13
PAN61 2     NACHT, LRR And PYD Containing Protein 122
RNO21 2     NACHT, LRR And PYD Domains-Containing Protein 122
NACHT, Leucine Rich Repeat And PYD Containing 121 2     Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain
Containing 122
Regulated By Nitric Oxide2 3     Monarch-13

External Ids:    HGNC: 229381   Entrez Gene: 916622   Ensembl: ENSG000001424057   OMIM: 6096485   UniProtKB: P590463   

Export aliases for NLRP12 gene to outside databases

Previous GC identifers: GC19M058989 GC19M050616


Summaries
for NLRP12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NLRP12:
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an
N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region,
functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes.
Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of
some of these has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NAL12_HUMAN, P59046
Function: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK

Gene Wiki entry for NLRP12


Genomic Views
for NLRP12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NLRP12 gene promoter:
         STAT5B   USF1   AML1a   CUTL1   STAT5A   Arnt   Max   USF-1   En-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NLRP12 promoter sequence
   Search SABiosciences Chromatin IP Primers for NLRP12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLRP12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

NLRP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLRP12 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054296:  view genomic region     (about GC identifiers)

Start:
 54,296,838 bp from pter      End:
 54,327,648 bp from pter
Size:
 30,811 bases      Orientation:
 minus strand

Proteins
for NLRP12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NAL12_HUMAN, P59046 (See protein sequence)
Recommended Name: NACHT, LRR and PYD domains-containing protein 12  
Size: 1061 amino acids; 120173 Da
Subunit: Binds to ASC with its DAPIN domain. Interacts with FAF1 UBA domain via its DAPIN domain
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for NLRP12:
2L6A (3D)    
Secondary accessions: Q8NEU4 Q9BY26
Alternative splicing: 5 isoforms:  P59046-1   P59046-2   P59046-3   P59046-4   P59046-5   

Explore the universe of human proteins at neXtProt for NLRP12: NX_P59046

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P59046

    • NLRP12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_150639.1  NP_653288.1  

    ENSEMBL proteins: 
     ENSP00000319377   ENSP00000375655   ENSP00000375653   ENSP00000341428   ENSP00000375652  
     ENSP00000438030   ENSP00000340473   ENSP00000346231   ENSP00000351487  

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    Uscn Proteins for NLRP12

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12019269


    NLRP12 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NLRP12

    Protein Domains /
    Families
    for NLRP12 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NLRP12 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR007111 NACHT_NTPase
     IPR001611 Leu-rich_rpt
     IPR004020 DAPIN
     IPR011029 DEATH-like_dom

    Graphical View of Domain Structure for InterPro Entry P59046

    ProtoNet protein and cluster: P59046

    3 Blocks protein families:
    IPB001611 Leucine-rich repeat signature
    IPB003590 Leucine-rich repeat
    IPB004020 Pyrin domain


    UniProtKB/Swiss-Prot: NAL12_HUMAN, P59046
    Similarity: Belongs to the NLRP family
    Similarity: Contains 1 DAPIN domain
    Similarity: Contains 8 LRR (leucine-rich) repeats
    Similarity: Contains 1 NACHT domain


    Function
    for NLRP12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NAL12_HUMAN, P59046
    Function: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK
    Induction: By nitric oxide and DMSO in HL-60 cells, an acute myeloid leukemia cell line

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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19337385
    GO:0005524ATP binding IEA--
    GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process NAS12019269


    NLRP12 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for NLRP12: Nlrp12tm1Tdk Nlrp12tm1Jpyt
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nlrp12):
     cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     tumorigenesis 

    NLRP12 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NLRP12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    		NOD pathway0.23


    1 BioSystems Pathway for NLRP12 
        NOD pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NLRP12

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/10 Interacting proteins for NLRP12 (P590462, 3 ENSP000003193774) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRAK1P516173, ENSP000003589974I2D: score=2 STRING: ENSP00000358997
    HSPA1AP081073I2D: score=1 
    HSPA1BP081073I2D: score=1 
    PYCARDQ9ULZ33, ENSP000002474704I2D: score=1 STRING: ENSP00000247470
    FAF1Q9UNN53I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process NAS12019269
    GO:0007165signal transduction NAS12019269
    GO:0008588release of cytoplasmic sequestered NF-kappaB IDA12019269
    GO:0009968negative regulation of signal transduction IDA16203735
    GO:0031953negative regulation of protein autophosphorylation IDA16203735


    NLRP12 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NLRP12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NLRP12 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NLRP12
    8 Novoseek chemical compound relationships for NLRP12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 61.9 16 11007795 (2), 9806887 (2), 12437997 (1), 18973232 (1) (see all 14)
    leucine 45.6 15 8514855 (2), 7758824 (2), 15153572 (1), 9681719 (1) (see all 9)
    cysteine 34.1 2 9642227 (1), 18343406 (1)
    glycosaminoglycan 17.7 1 11603505 (1)
    estrogen 0 4 20014005 (1), 15579769 (1), 17545633 (1)
    arginine 0 3 11007795 (2), 11731272 (1)
    glutamate 0 3 20014005 (1), 15579769 (1), 17545633 (1)
    serine 0 1 8988362 (1)

    Search CenterWatch for drugs/clinical trials and news about NLRP12 / NAL12 

    Transcripts
    for NLRP12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NLRP12 gene (2 alternative transcripts): 
    NM_033297.2  NM_144687.2  

    Unigene Cluster for NLRP12:

    NLR family, pyrin domain containing 12
    Hs.631573  [show with all ESTs]
    Unigene Representative Sequence: NM_144687
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324134(uc002qch.4 uc002qci.4 uc002qcj.4) ENST00000391775
    ENST00000492915 ENST00000391773 ENST00000345770 ENST00000473605 ENST00000391772
    ENST00000535162 ENST00000351894(uc002qck.4) ENST00000354278(uc010eqx.3)
    ENST00000358661(uc010eqw.3)

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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF231021.1 AK095460.1 AK290772.1 AY095146.1 AY116204.1 AY116205.1 AY116206.1 AY116207.1 
    AY154467.1 BC028069.1 

    3 DOTS entries:

    DT.95084512  DT.100024228  DT.95248774 

    23 AceView cDNA sequences:

    BC028069 AY116207 AY116204 BQ920369 AY116205 BQ710940 AF231021 AK095460 
    BI519910 BQ957631 NM_144687 AY116206 AA514928 NM_033297 CA436253 BI911853 
    AY095146 AY154467 BQ900330 AA358140 AW956628 AW817041 BM043219 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NLRP12    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                        -                     
    SP4:                                                  -     -                     


    ECgene alternative splicing isoforms for NLRP12

    Expression
    for NLRP12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NLRP12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATGTAATCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NLRP12 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NLRP12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NLRP12

    SOURCE GeneReport for Unigene cluster: Hs.631573

    UniProtKB/Swiss-Prot: NAL12_HUMAN, P59046
    Tissue specificity: Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at
    lower levels in monocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including NLRP12: 
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for NLRP12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NLRP12 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 27(a)
    		 possible ortholog
    		 GL343281.1(869690-874415)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-213a13.26
    si:ch211-213a13.56
    (see all 220)    		 si:ch211-213a13.5
    (see all 220)    		 8(a)
    8(a)
    (see all 220)    		 many ↔ many
    many ↔ many
    (see all 220)    		 22(8948738-8996350)
    22(9090823-9139153)


    ENSEMBL Gene Tree for NLRP12 (if available)
    TreeFam Gene Tree for NLRP12 (if available) 

    Paralogs
    for NLRP12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NLRP12 gene
    NLRP132  NLRP42  NLRP92  NLRP62  NLRP32  NLRP142  NLRP72  NLRP112  
    NLRP102  NLRP22  NLRP52  NLRP12  NLRP82  
    15 SIMAP similar genes for NLRP12 using alignment to 6 protein entries:     NAL12_HUMAN (see all proteins):
    CIAS1    NLRP3    RNH1    NLRP1    PP1579    NLRP14
    NLRP10    NLRP13    NLRP9    NLRP6    NLRP2    NLRP4
    NLRP5    NLRP7    NLRP8

    NLRP12 for paralogs           About GeneDecksing



    Genomic Variants
    for NLRP12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/862 NCBI SNPs in NLRP12 are shown (see all 862)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1048955641,2
    		C,F,pathogenic54314063(-) TCATCC/TGAGTT 2 R * stg11Minor allele frequency- T:0.00NA 4520
    rs1994762471,2
    		C,F,untested54301483(-) CGGGGA/GGTGAC 2 -- int11Minor allele frequency- G:0.00EU 1323
    rs1048955701,2
    		C,F,untested54301594(-) ACCTCC/AGGGAG 3 /R int1 syn12Minor allele frequency- A:0.00NA EU 5813
    rs1048955691,2
    		C,F,untested54301640(-) TCTGCC/TGCCTG 3 A syn1 int13Minor allele frequency- T:0.02WA NA EU 5689
    rs1048955681,2
    		C,F,untested54304536(-) TCGGGG/CTGCTG 4 /L /V mis11Minor allele frequency- C:0.00NA 4542
    rs1048955671,2
    		C,F,untested54310714(-) GTGGTC/TCCCAC 2 -- int13Minor allele frequency- T:0.08CSA WA 122
    rs1994758681,2
    		C,untested54310827(-) GTACCA/GAAATG 3 Q R ut51 mis10--------
    rs1048955661,2
    		Cuntested54313570(-) GCCGGG/CGGCCC 3 /A /G us2k1 mis11Minor allele frequency- C:0.00EU 1323
    rs1421082771,2
    		--54296452(+) CCTACC/TGGCCA 2 -- ds50010--------
    rs1390942621,2
    		--54296484(+) TGCCCA/CGGCTG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for NLRP12 (54296838 - 54327648 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NLRP12: --
    Human Gene Mutation Database (HGMD): NLRP12

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    Disorders / Diseases
    for NLRP12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NLRP12 for disorders           About GeneDecksing

    OMIM gene information: 609648   
    OMIM disorders: 611762  
    UniProtKB/Swiss-Prot: NAL12_HUMAN, P59046
  • Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS
    • are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and
    conjunctivitis after generalized exposure to cold

    20/34 diseases for NLRP12 (see all 34):    About MalaCards
    x-linked congenital stationary night blindness    acid-labile subunit    familial cold autoinflammatory syndrome    congenital stationary night blindness
    familial cold autoinflammatory syndrome 2    night blindness    temporal lobe epilepsy    periodic fever
    blindness    atopic dermatitis    chronic lymphocytic leukemia    acute myeloid leukemia
    progeria    syphilis    lymphocytic leukemia    myeloid leukemia
    squamous cell carcinoma    gastroenteritis    schistosomiasis    rheumatoid arthritis

    4 Novoseek disease relationships for NLRP12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    csnb1 74.8 1 16553780 (1)
    collagen fibril 61.2 1 14660626 (1)
    night blindness, congenital stationary 59.2 1 11062472 (1)
    tumors 4.77 1 15579769 (1)

    Human Genome Epidemiology (HuGE) Navigator: NLRP12 (6 documents)

    Export disorders for NLRP12 gene to outside databases

    Publications
    for NLRP12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NLRP12 gene, integrated from 9 sources (see all 119):
    (articles sorted by number of sources associating them with NLRP12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. NALPs: a novel protein family involved in inflammation. (PubMed id 12563287)1, 2, 3 Tschopp J....Burns K. (2003)
    2. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. (PubMed id 12019269)1, 2, 3 Wang L.... Bertin J. (2002)
    3. The NLRP12 pyrin domain: structure, dynamics, and fun ctional insights. (PubMed id 21978668)1, 2 Pinheiro A.S....Peti W. (2011)
    4. ATP binding by monarch-1/NLRP12 is critical for its inhibitory function. (PubMed id 18160710)1, 2 Ye Z....Ting J.P. (2008)
    5. Mutations in NALP12 cause hereditary periodic fever syndromes. (PubMed id 18230725)1, 2 Jeru I....Amselem S. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Identification and characterization of a novel gene that is upregulated in leukaemia cells by nitric oxide. (PubMed id 11167794)1, 2 Shami P.J.... Parker C.J. (2001)
    8. Inflammasome mRNA expression in human monocytes during early septic shock. (PubMed id 18263805)1, 9 Fahy R.J....Wewers M.D. (2008)
    9. Identification and functional consequences of a recur rent NLRP12 missense mutation in periodic fever syndromes. (PubMed id 21538323)1 JAcru I....Amselem S. (2011)
    10. Clinical presentation and pathogenesis of cold-induced autoinflammatory disease in a family with recurrence of an NLRP12 mutation. (PubMed id 21360512)1 Borghini S....Gattorno M. (2011)

    External Searches for NLRP12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NLRP12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91662 HGNC: 22938 AceView: NALP12 Ensembl:ENSG00000142405 euGenes: HUgn91662
    ECgene: NLRP12 H-InvDB: NLRP12

    Other Databases showing NLRP12 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NLRP12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NLRP12 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NLRP12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NLRP12 gene:
    Search GeneIP for patents involving NLRP12

    GeneCards and IP:
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