Aliases for NLRP11 Gene
- PAN10 3 4
- Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 11 3
- Leucine Rich Repeat And Pyrin Domain Containing 11 2
- NACHT, LRR And PYD Domains-Containing Protein 11 3
- Nucleotide-Binding Oligomerization Domain 2
- PAAD- And NACHT-Containing Protein 10B 3
- CLR19.6 3
External Ids for NLRP11 Gene
Previous HGNC Symbols for NLRP11 Gene
Previous GeneCards Identifiers for NLRP11 Gene
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
GeneCards Summary for NLRP11 Gene
NLRP11 (NLR Family, Pyrin Domain Containing 11) is a Protein Coding gene. Diseases associated with NLRP11 include necrotizing fasciitis. GO annotations related to this gene include oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen. An important paralog of this gene is NLRC3.
UniProtKB/Swiss-Prot for NLRP11 Gene
Involved in inflammation.