Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NLRP11 Gene

Aliases for NLRP11 Gene

  • NLR Family, Pyrin Domain Containing 11 2 3
  • NALP11 3 4 6
  • NOD17 3 4 6
  • Nucleotide-Binding Oligomerization Domain Protein 17 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 11 2 3
  • PAAD-And NACHT Domain-Containing Protein 10 3 4
  • PYRIN-Containing APAF1-Like Protein 6 3 4
  • PYPAF7 3 6
  • PYPAF6 3 4
  • PAN10 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 11 3
  • Leucine Rich Repeat And Pyrin Domain Containing 11 2
  • NACHT, LRR And PYD Domains-Containing Protein 11 3
  • Nucleotide-Binding Oligomerization Domain 2
  • PAAD- And NACHT-Containing Protein 10B 3
  • CLR19.6 3

External Ids for NLRP11 Gene

Previous HGNC Symbols for NLRP11 Gene

  • NALP11

Previous GeneCards Identifiers for NLRP11 Gene

  • GC19M060989
  • GC19M056298
  • GC19M052608

Summaries for NLRP11 Gene

Entrez Gene Summary for NLRP11 Gene

  • NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NLRP11 Gene

NLRP11 (NLR Family, Pyrin Domain Containing 11) is a Protein Coding gene. Diseases associated with NLRP11 include necrotizing fasciitis. GO annotations related to this gene include oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen. An important paralog of this gene is NLRC3.

UniProtKB/Swiss-Prot for NLRP11 Gene

  • Involved in inflammation.

Gene Wiki entry for NLRP11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP11 Gene

Genomics for NLRP11 Gene

Regulatory Elements for NLRP11 Gene

Genomic Location for NLRP11 Gene

Start:
55,785,397 bp from pter
End:
55,836,800 bp from pter
Size:
51,404 bases
Orientation:
Minus strand

Genomic View for NLRP11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLRP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP11 Gene

Proteins for NLRP11 Gene

  • Protein details for NLRP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59045-NAL11_HUMAN
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 11
    Protein Accession:
    P59045
    Secondary Accessions:
    • C9JSF5
    • Q2TV85
    • Q2TV86
    • Q53ZZ0
    • Q8NBF5

    Protein attributes for NLRP11 Gene

    Size:
    1033 amino acids
    Molecular mass:
    117779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03490.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NLRP11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NLRP11 Gene

Proteomics data for NLRP11 Gene at MOPED

Post-translational modifications for NLRP11 Gene

  • Ubiquitination at Lys917
  • Modification sites at PhosphoSitePlus

Other Protein References for NLRP11 Gene

No data available for DME Specific Peptides for NLRP11 Gene

Domains for NLRP11 Gene

Gene Families for NLRP11 Gene

HGNC:
  • NLR :Nucleotide-binding domain and leucine rich repeat containing
IUPHAR :

Suggested Antigen Peptide Sequences for NLRP11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59045

UniProtKB/Swiss-Prot:

NAL11_HUMAN :
  • P59045
Domain:
  • Contains 1 DAPIN domain.
  • Contains 1 NACHT domain.
Family:
  • Belongs to the NLRP family.
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRP11: view

Function for NLRP11 Gene

Molecular function for NLRP11 Gene

UniProtKB/Swiss-Prot Function: Involved in inflammation.

Gene Ontology (GO) - Molecular Function for NLRP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NLRP11: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NLRP11 Gene

Localization for NLRP11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLRP11 Gene COMPARTMENTS Subcellular localization image for NLRP11 gene
Compartment Confidence
plasma membrane 3
cytosol 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NLRP11 Gene

Pathways for NLRP11 Gene

SuperPathways for NLRP11 Gene

No Data Available

Interacting Proteins for NLRP11 Gene

Gene Ontology (GO) - Biological Process for NLRP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NLRP11: view

No data available for Pathways by source for NLRP11 Gene

Transcripts for NLRP11 Gene

Unigene Clusters for NLRP11 Gene

NLR family, pyrin domain containing 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP11 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: -

Relevant External Links for NLRP11 Gene

GeneLoc Exon Structure for
NLRP11
ECgene alternative splicing isoforms for
NLRP11

Expression for NLRP11 Gene

mRNA expression in normal human tissues for NLRP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP11 Gene

This gene is overexpressed in Testis (22.2), Liver (8.9), and Ovary (4.2).

SOURCE GeneReport for Unigene cluster for NLRP11 Gene Hs.375039

genes like me logo Genes that share expressions with NLRP11: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for NLRP11 Gene

Orthologs for NLRP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRP11 35
  • 99.35 (n)
  • 98.84 (a)
NLRP11 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
OneToMany
Species with no ortholog for NLRP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP11 Gene

ENSEMBL:
Gene Tree for NLRP11 (if available)
TreeFam:
Gene Tree for NLRP11 (if available)

Paralogs for NLRP11 Gene

Selected SIMAP similar genes for NLRP11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NLRP11: view

Variants for NLRP11 Gene

Sequence variations from dbSNP and Humsavar for NLRP11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs299163 - 55,810,048(-) TCACT(G/T)CTCAC reference, missense, upstream-variant-2KB, nc-transcript-variant
rs299164 -- 55,808,430(-) CACCA(A/C)ATGTC intron-variant
rs299165 -- 55,808,159(-) TCATG(C/T)TTGAC intron-variant
rs299166 -- 55,807,402(-) GCAAA(A/T)ATGGG intron-variant
rs299167 -- 55,806,437(-) aattg(C/T)cccaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLRP11 Gene

Variant ID Type Subtype PubMed ID
nsv833882 CNV Loss 17160897
nsv510927 CNV Complex 20534489
nsv912505 CNV Gain 21882294
nsv912506 CNV Gain 21882294
dgv1132e1 CNV Complex 17122850
nsv509753 CNV Insertion 20534489
nsv2556 CNV Insertion 18451855
essv183 CNV CNV 17122850
nsv526248 CNV Loss 19592680
nsv525923 CNV Loss 19592680
esv2660360 CNV Deletion 23128226
esv2718989 CNV Deletion 23290073
esv2586154 CNV Deletion 19546169

Relevant External Links for NLRP11 Gene

HapMap Linkage Disequilibrium report
NLRP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP11 Gene

Disorders for NLRP11 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NLRP11 Gene including...

Search for NLRP11 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NLRP11 Gene

Relevant External Links for NLRP11

Genetic Association Database (GAD)
NLRP11
Human Genome Epidemiology (HuGE) Navigator
NLRP11
genes like me logo Genes that share disorders with NLRP11: view

No data available for UniProtKB/Swiss-Prot for NLRP11 Gene

Publications for NLRP11 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4
  2. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. (PMID: 12019269) Wang L. … Bertin J. (J. Biol. Chem. 2002) 2 3 4
  3. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. (PMID: 12387869) Grenier J.M. … Bertin J. (FEBS Lett. 2002) 3 23
  4. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L. … Lunetta K.L. (Nat. Genet. 2012) 3 48
  5. Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. (PMID: 12615073) Dowds T.A. … Nunez G. (Biochem. Biophys. Res. Commun. 2003) 3 4

Products for NLRP11 Gene

Sources for NLRP11 Gene

Back to Top

Content