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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NLRP11 Gene

protein-coding   GIFtS: 51
GCID: GC19M056298

NLR family, pyrin domain containing 11

(Previous names: NACHT, leucine rich repeat and PYD containing 11 )
(Previous symbol: NALP11)
 Explore 8 diseases affiliated with
NLRP11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NLRP11    

Aliases
for NLRP11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NLR Family, Pyrin Domain Containing 111 2     PAAD-And NACHT Domain-Containing Protein 102 3
NALP111 2 3 5     PYRIN-Containing APAF1-Like Protein 62 3
NOD171 2 3 5     PYPAF72 5
PAN101 2 3     NACHT, LRR And PYD Containing Protein 112
PYPAF61 2 3     NACHT, LRR And PYD Domains-Containing Protein 112
CLR19.61 2     Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain
Containing 112
NACHT, Leucine Rich Repeat And PYD Containing 111 2     PAAD- And NACHT-Containing Protein 102
Nucleotide-Binding Oligomerization Domain Protein 172 3     PAAD- And NACHT-Containing Protein 10B2

External Ids:    HGNC: 229451   Entrez Gene: 2048012   Ensembl: ENSG000001798737   OMIM: 6096645   UniProtKB: P590453   

Export aliases for NLRP11 gene to outside databases

Previous GC identifers: GC19M060989 GC19M052608


Summaries
for NLRP11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NLRP11:
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs,
such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a
NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636),
also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD).
NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in
multiprotein complexes called inflammasomes (Tschopp et al., 2003 (PubMed 12563287)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: NAL11_HUMAN, P59045
Function: Involved in inflammation (Potential)

Gene Wiki entry for NLRP11


Genomic Views
for NLRP11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NLRP11 gene promoter:
         AML1a   NF-kappaB   E47   AREB6   CBF-A   CBF-B   NF-kappaB1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NLRP11 promoter sequence
   Search SABiosciences Chromatin IP Primers for NLRP11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLRP11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

NLRP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLRP11 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M056298:  view genomic region     (about GC identifiers)

Start:
 56,296,763 bp from pter      End:
 56,348,166 bp from pter
Size:
 51,404 bases      Orientation:
 minus strand

Proteins
for NLRP11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NAL11_HUMAN, P59045 (See protein sequence)
Recommended Name: NACHT, LRR and PYD domains-containing protein 11  
Size: 1033 amino acids; 117779 Da
Sequence caution: Sequence=BAC03490.1; Type=Erroneous initiation;
Secondary accessions: C9JSF5 Q2TV85 Q2TV86 Q53ZZ0 Q8NBF5
Alternative splicing: 3 isoforms:  P59045-1   P59045-2   P59045-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NLRP11: NX_P59045

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P59045

    • NLRP11 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_659444.2  
    ENSEMBL proteins: 
     ENSP00000468701   ENSP00000466507   ENSP00000468082   ENSP00000468196   ENSP00000466285  
     ENSP00000466582   ENSP00000467988   ENSP00000468696   ENSP00000409898   ENSP00000353251  

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    Uscn Proteins for NLRP11


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    Uscn ELISAs and CLIAs for NLRP11

    Protein Domains /
    Families
    for NLRP11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NLRP11 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020611 Cu2_ascorb_mOase_CS-1
     IPR007111 NACHT_NTPase
     IPR004020 DAPIN
     IPR011029 DEATH-like_dom

    Graphical View of Domain Structure for InterPro Entry P59045

    ProtoNet protein and cluster: P59045

    4 Blocks protein families:
    IPB001209 Ribosomal protein S14
    IPB001611 Leucine-rich repeat signature
    IPB003590 Leucine-rich repeat
    IPB004020 Pyrin domain


    UniProtKB/Swiss-Prot: NAL11_HUMAN, P59045
    Similarity: Belongs to the NLRP family
    Similarity: Contains 1 DAPIN domain
    Similarity: Contains 6 LRR (leucine-rich) repeats
    Similarity: Contains 1 NACHT domain


    Function
    for NLRP11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NAL11_HUMAN, P59045
    Function: Involved in inflammation (Potential)

    miRNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0016715oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA--


    NLRP11 for ontologies           About GeneDecksing



    Pathways & Interactions
    for NLRP11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NLRP11

    Drugs & Compounds
    for NLRP11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NLRP11
    Search CenterWatch for drugs/clinical trials and news about NLRP11 / NAL11 

    Transcripts
    for NLRP11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NLRP11 gene: 
    NM_145007.3  

    Unigene Cluster for NLRP11:

    NLR family, pyrin domain containing 11
    Hs.375039  [show with all ESTs]
    Unigene Representative Sequence: NM_145007
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585621 ENST00000590363 ENST00000589824 ENST00000592953 ENST00000589093
    ENST00000590409 ENST00000593244 ENST00000593208 ENST00000443188(uc002qmb.3 uc010ygf.2 uc002qmc.3 uc010ete.1)
    ENST00000360133(uc002qlz.3)

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK090621.1 AK129784.1 AK310394.1 AY095145.1 AY154466.1 AY168967.1 AY168968.1 AY226382.1 
    BC034730.1 BC036506.1 

    5 DOTS entries:

    DT.100019248  DT.91907117  DT.95150835  DT.104757  DT.91846373 

    20 AceView cDNA sequences:

    AY154466 AK097646 AK129784 AY226382 BC036506 AK090621 NM_145007 BM476390 
    BF975539 BG686053 BM804437 AY095145 BC034730 BU622142 AX746538 BG759089 
    BI459025 AA976034 BF797150 BG685962 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NLRP11    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                            
    SP2:                    -                                       


    ECgene alternative splicing isoforms for NLRP11

    Expression
    for NLRP11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NLRP11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTACGTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NLRP11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for NLRP11

    SOURCE GeneReport for Unigene cluster: Hs.375039
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    In Situ
    Assay Products:     
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    Orthologs
    for NLRP11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NLRP11 gene from 2/4 species (see all 4)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia NLRP66
    --
    		 --
    		 24(a)
    21(a)
    		 1 ↔ many
    possible ortholog
    		 GL343482.1(99797-112078)
    GL343281.1(869690-874415)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-213a13.26
    si:ch211-213a13.56
    (see all 220)    		 si:ch211-213a13.5
    (see all 220)    		 6(a)
    6(a)
    (see all 220)    		 many ↔ many
    many ↔ many
    (see all 220)    		 22(8948738-8996350)
    22(9090823-9139153)


    ENSEMBL Gene Tree for NLRP11 (if available)
    TreeFam Gene Tree for NLRP11 (if available) 

    Paralogs
    for NLRP11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NLRP11 gene
    NLRP132  NLRP42  NLRP92  NLRP62  NLRP32  NLRP142  NLRP72  NLRP102  
    NLRP22  NLRP52  NLRP12  NLRP82  NLRP122  
    6 SIMAP similar genes for NLRP11 using alignment to 4 protein entries:     NAL11_HUMAN (see all proteins):
    CIAS1    RNH1    NLRP9    NLRP4    NLRP13    NLRP14

    NLRP11 for paralogs           About GeneDecksing



    Genomic Variants
    for NLRP11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1192 NCBI SNPs in NLRP11 are shown (see all 1192)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs739333631,2
    		C,--56296293(+) GGGCAC/TTGTAA 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1394059471,2
    		--56296395(+) CCACAC/TATATC 1 -- int10--------
    rs21128311,2
    		C,F,A,--56296492(+) AGATAC/GGGAAA 1 -- int17Minor allele frequency- G:0.16WA NA CSA EA 366
    rs21128321,2
    		C,F,A,H,--56296555(+) AATACG/TAAGTC 1 -- int121Minor allele frequency- T:0.20NS EA NA WA CSA 2348
    rs21128331,2
    		C,F,A,H,--56296582(+) TGAGGA/TTTTCA 1 -- int121Minor allele frequency- T:0.21NS EA NA WA CSA 2342
    rs1898754201,2
    		--56296586(+) GATTTC/TATTTC 1 -- int10--------
    rs21128341,2
    		C,F,A,H,--56296608(+) AGGGAC/TACCTT 1 -- int120Minor allele frequency- T:0.39NS EA NA WA CSA 1214
    rs1482489101,2
    		C,--56296634(+) AGACC-/AAAACAAA
    AACAAAAACA    AAAAC     		1 -- int10--------
    rs177085671,2
    		C,F,H,--56296833(+) TAGGAA/CTTTGA 1 -- ut31 ese38Minor allele frequency- C:0.02NA NS EA 682
    rs1996294731,2
    		--56296858(+) TCAAG-/GTCACAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NLRP11 (56296763 - 56348166 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for NLRP11
         3 CNVs: 35687 3202 102884

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    Disorders / Diseases
    for NLRP11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NLRP11 for disorders           About GeneDecksing

    OMIM gene information: 609664    OMIM disorders: --

    8 diseases for NLRP11:    About MalaCards
    necrotizing fasciitis    familial mediterranean fever    chronic lymphocytic leukemia    lymphocytic leukemia
    fasciitis    multiple sclerosis    crohn's disease    leukemia

    1 disease from the University of Copenhagen DISEASES database for NLRP11:
    Necrotizing fasciitis
    Human Genome Epidemiology (HuGE) Navigator: NLRP11 (2 documents)

    Export disorders for NLRP11 gene to outside databases

    Publications
    for NLRP11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NLRP11 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with NLRP11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. NALPs: a novel protein family involved in inflammation. (PubMed id 12563287)1, 2, 3 Tschopp J....Burns K. (2003)
    2. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. (PubMed id 12019269)1, 2, 3 Wang L.... Bertin J. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. (PubMed id 12615073)1, 2 Dowds T.A.... Nunez G. (2003)
    6. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. (PubMed id 12387869)1, 9 Grenier J.M.... Bertin J. (2002)
    7. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PubMed id 22267201)1 Stolk L....Lunetta K.L. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. The genetics of NOD-like receptors in Crohn's disease . (PubMed id 20403135)1 Cummings J.R....Jewell D.P. (2010)

    External Searches for NLRP11 gene

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    Genome Databases showing NLRP11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 204801 HGNC: 22945 AceView: NALP11 Ensembl:ENSG00000179873 euGenes: HUgn204801
    ECgene: NLRP11 H-InvDB: NLRP11

    Other Databases showing NLRP11 gene

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    Specialized Databases showing NLRP11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NLRP11 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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