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Aliases for NLRP10 Gene

Aliases for NLRP10 Gene

  • NLR Family Pyrin Domain Containing 10 2 3 5
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 10 2 3
  • Nucleotide-Binding Oligomerization Domain Protein 8 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 10 2 3
  • NALP10 3 4
  • PYNOD 3 4
  • NOD8 3 4
  • NACHT, LRR And PYD Domains-Containing Protein 10 3
  • CLR11.1 3
  • PAN5 3

External Ids for NLRP10 Gene

Previous HGNC Symbols for NLRP10 Gene

  • NALP10

Previous GeneCards Identifiers for NLRP10 Gene

  • GC11M007938
  • GC11M007980
  • GC11M007647

Summaries for NLRP10 Gene

Entrez Gene Summary for NLRP10 Gene

  • Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for NLRP10 Gene

NLRP10 (NLR Family Pyrin Domain Containing 10) is a Protein Coding gene. Diseases associated with NLRP10 include Irritant Dermatitis. Among its related pathways are Nucleotide-binding Oligomerization Domain (NOD) pathway. An important paralog of this gene is NLRP3.

UniProtKB/Swiss-Prot for NLRP10 Gene

  • Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.

Gene Wiki entry for NLRP10 Gene

Additional gene information for NLRP10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP10 Gene

Genomics for NLRP10 Gene

Regulatory Elements for NLRP10 Gene

Enhancers for NLRP10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H007904 0.9 Ensembl ENCODE 15.6 +58.8 58842 4 CTCF CEBPB KLF4 RAD21 POLR2A SCRT2 GLIS1 ZBTB33 TCF7L2 NLRP10 OR10A6 OR10A3 OVCH2 CASC23 TUB EIF3F LOC283299
GH11H007962 1.1 Ensembl ENCODE dbSUPER 11.2 -1.3 -1307 8 TBP CC2D1A JUND POLR2A FOS EGR2 NLRP10 OR10A3 CASC23 TUB GC11M007966
GH11H007900 0.6 ENCODE 16.1 +63.8 63846 2 SMARCE1 CTBP1 GATA3 CEBPB FOS HNF4A DPF2 NLRP10 OR10A6 OR10A3 CASC23 TUB OVCH2 PIR62490 PIR32361
GH11H007571 1.5 Ensembl ENCODE dbSUPER 5.3 +389.5 389492 9 PKNOX1 FOXA2 ATF1 MLX ARID4B FEZF1 DMAP1 BRCA1 YY1 SLC30A9 OLFML1 OVCH2 PPFIBP2 NLRP10 LOC105376535 GC11M007541
GH11H007898 0.6 ENCODE 10.4 +65.9 65948 1 PKNOX1 CEBPB JUNB BATF EP300 GATA3 STAT3 RCOR1 TCF7L2 OR10A3 NLRP10 PIR32361 PIR41542
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NLRP10 on UCSC Golden Path with GeneCards custom track

Genomic Location for NLRP10 Gene

Chromosome:
11
Start:
7,959,023 bp from pter
End:
7,965,426 bp from pter
Size:
6,404 bases
Orientation:
Minus strand

Genomic View for NLRP10 Gene

Genes around NLRP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP10 Gene

Proteins for NLRP10 Gene

  • Protein details for NLRP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W26-NAL10_HUMAN
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 10
    Protein Accession:
    Q86W26
    Secondary Accessions:
    • Q2M3C4
    • Q6JGT0

    Protein attributes for NLRP10 Gene

    Size:
    655 amino acids
    Molecular mass:
    75032 Da
    Quaternary structure:
    • Oligomerizes. Interacts with PYCARD, CASP1 and IL1B. Also interacts with NOD1 and components of the NOD1 signaling pathway including RIPK2, NR2C2/TAK1 and IKBKG/NEMO.

    Three dimensional structures from OCA and Proteopedia for NLRP10 Gene

neXtProt entry for NLRP10 Gene

Post-translational modifications for NLRP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NLRP10 Gene

Domains & Families for NLRP10 Gene

Gene Families for NLRP10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NLRP10 Gene

Suggested Antigen Peptide Sequences for NLRP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W26

UniProtKB/Swiss-Prot:

NAL10_HUMAN :
  • The pyrin and ATP-binding domains are required to elicit cytokine release following bacterial infection.
  • Belongs to the NLRP family.
Domain:
  • The pyrin and ATP-binding domains are required to elicit cytokine release following bacterial infection.
  • The NACHT domain is required for inhibition of CASP1 autoprocessing.
Family:
  • Belongs to the NLRP family.
genes like me logo Genes that share domains with NLRP10: view

Function for NLRP10 Gene

Molecular function for NLRP10 Gene

UniProtKB/Swiss-Prot Function:
Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.

Phenotypes From GWAS Catalog for NLRP10 Gene

Gene Ontology (GO) - Molecular Function for NLRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRP10: view
genes like me logo Genes that share phenotypes with NLRP10: view

Animal Models for NLRP10 Gene

MGI Knock Outs for NLRP10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NLRP10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NLRP10 Gene

Localization for NLRP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRP10 Gene

Cytoplasm. Cell membrane. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NLRP10 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NLRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 22672233
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0019897 extrinsic component of plasma membrane IDA 22672233
genes like me logo Genes that share ontologies with NLRP10: view

Pathways & Interactions for NLRP10 Gene

genes like me logo Genes that share pathways with NLRP10: view

Pathways by source for NLRP10 Gene

1 BioSystems pathway for NLRP10 Gene

Interacting Proteins for NLRP10 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000327763%0d%0a9606.ENSP00000363822%0d%0a
Selected Interacting proteins: Q86W26-NAL10_HUMAN ENSP00000327763 for NLRP10 Gene via IID STRING

Gene Ontology (GO) - Biological Process for NLRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002827 positive regulation of T-helper 1 type immune response ISS,IEA --
GO:0035397 helper T cell enhancement of adaptive immune response IEA,ISS --
GO:0036336 dendritic cell migration ISS,IEA --
genes like me logo Genes that share ontologies with NLRP10: view

No data available for SIGNOR curated interactions for NLRP10 Gene

Drugs & Compounds for NLRP10 Gene

No Compound Related Data Available

Transcripts for NLRP10 Gene

mRNA/cDNA for NLRP10 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NLRP10 Gene

NLR family, pyrin domain containing 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NLRP10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP10 Gene

No ASD Table

Relevant External Links for NLRP10 Gene

GeneLoc Exon Structure for
NLRP10
ECgene alternative splicing isoforms for
NLRP10

Expression for NLRP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NLRP10 Gene

mRNA differential expression in normal tissues according to GTEx for NLRP10 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x24.1) and Skin - Not Sun Exposed (Suprapubic) (x16.9).

Protein differential expression in normal tissues from HIPED for NLRP10 Gene

This gene is overexpressed in Bone (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NLRP10 Gene



Protein tissue co-expression partners for NLRP10 Gene

NURSA nuclear receptor signaling pathways regulating expression of NLRP10 Gene:

NLRP10

SOURCE GeneReport for Unigene cluster for NLRP10 Gene:

Hs.449636

mRNA Expression by UniProt/SwissProt for NLRP10 Gene:

Q86W26-NAL10_HUMAN
Tissue specificity: Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis. Little expression detected in myeloid cells or peripheral blood mononuclear cells.

Evidence on tissue expression from TISSUES for NLRP10 Gene

  • Heart(4.2)
genes like me logo Genes that share expression patterns with NLRP10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLRP10 Gene

Orthologs for NLRP10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRP10 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia NLRP10 33 34
  • 80.55 (n)
rat
(Rattus norvegicus)
Mammalia Nlrp10 33
  • 75.16 (n)
mouse
(Mus musculus)
Mammalia Nlrp10 33 16 34
  • 75.03 (n)
oppossum
(Monodelphis domestica)
Mammalia NLRP10 34
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NLRP10 34
  • 44 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 16 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 14 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-66k16.2 34
  • 21 (a)
ManyToMany
CU693495.1 34
  • 18 (a)
ManyToMany
nlrb5 34
  • 18 (a)
ManyToMany
si:ch211-66k16.28 34
  • 11 (a)
ManyToMany
Species where no ortholog for NLRP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NLRP10 Gene

ENSEMBL:
Gene Tree for NLRP10 (if available)
TreeFam:
Gene Tree for NLRP10 (if available)

Paralogs for NLRP10 Gene

(4) SIMAP similar genes for NLRP10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NLRP10: view

Variants for NLRP10 Gene

Sequence variations from dbSNP and Humsavar for NLRP10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs199475851 untested 7,963,947(+) GACAG(A/C)GTCTA intron-variant, upstream-variant-2KB
rs199475852 untested 7,963,799(+) CTCCC(C/T)CAAAC intron-variant, upstream-variant-2KB
rs199475853 untested 7,963,279(-) TGAAA(A/G/T)TTGTC reference, missense
rs199475854 untested 7,960,619(-) GATGA(A/G)AAGCA reference, synonymous-codon
rs199475855 untested 7,960,202(-) TTCCA(A/G)GACTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NLRP10 Gene

Variant ID Type Subtype PubMed ID
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855

Variation tolerance for NLRP10 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NLRP10 Gene

Human Gene Mutation Database (HGMD)
NLRP10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NLRP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP10 Gene

Disorders for NLRP10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NLRP10 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
irritant dermatitis
  • irritant contact dermatitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NLRP10

Genetic Association Database (GAD)
NLRP10
Human Genome Epidemiology (HuGE) Navigator
NLRP10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NLRP10
genes like me logo Genes that share disorders with NLRP10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NLRP10 Gene

Publications for NLRP10 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J … Burns K (Nature reviews. Molecular cell biology 2003) 2 3 4 60
  2. NLRP10 enhances Shigella-induced pro-inflammatory responses. (PMID: 22672233) Lautz K … Kufer TA (Cellular microbiology 2012) 3 4 60
  3. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings JR … Jewell DP (Tissue antigens 2010) 3 45 60
  4. Anti-inflammatory activity of PYNOD and its mechanism in humans and mice. (PMID: 20393137) Imamura R … Suda T (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for NLRP10 Gene

Sources for NLRP10 Gene

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