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Aliases for NLRP10 Gene

Aliases for NLRP10 Gene

  • NLR Family, Pyrin Domain Containing 10 2 3 5
  • Nucleotide-Binding Oligomerization Domain Protein 8 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 10 2 3
  • NALP10 3 4
  • PYNOD 3 4
  • NOD8 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 10 3
  • Leucine Rich Repeat And Pyrin Domain Containing 10 2
  • Nucleotide-Binding Oligomerization Domain 2
  • CLR11.1 3
  • PAN5 3

External Ids for NLRP10 Gene

Previous HGNC Symbols for NLRP10 Gene

  • NALP10

Previous GeneCards Identifiers for NLRP10 Gene

  • GC11M007938
  • GC11M007980
  • GC11M007647

Summaries for NLRP10 Gene

Entrez Gene Summary for NLRP10 Gene

  • Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for NLRP10 Gene

NLRP10 (NLR Family, Pyrin Domain Containing 10) is a Protein Coding gene. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. An important paralog of this gene is NLRP7.

UniProtKB/Swiss-Prot for NLRP10 Gene

  • Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.

Gene Wiki entry for NLRP10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP10 Gene

Genomics for NLRP10 Gene

Regulatory Elements for NLRP10 Gene

Enhancers for NLRP10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NLRP10 on UCSC Golden Path with GeneCards custom track

Genomic Location for NLRP10 Gene

Chromosome:
11
Start:
7,959,023 bp from pter
End:
7,965,426 bp from pter
Size:
6,404 bases
Orientation:
Minus strand

Genomic View for NLRP10 Gene

Genes around NLRP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP10 Gene

Proteins for NLRP10 Gene

  • Protein details for NLRP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W26-NAL10_HUMAN
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 10
    Protein Accession:
    Q86W26
    Secondary Accessions:
    • Q2M3C4
    • Q6JGT0

    Protein attributes for NLRP10 Gene

    Size:
    655 amino acids
    Molecular mass:
    75032 Da
    Quaternary structure:
    • Oligomerizes. Interacts with PYCARD, CASP1 and IL1B. Also interacts with NOD1 and components of the NOD1 signaling pathway including RIPK2, NR2C2/TAK1 and IKBKG/NEMO.

    Three dimensional structures from OCA and Proteopedia for NLRP10 Gene

neXtProt entry for NLRP10 Gene

Proteomics data for NLRP10 Gene at MOPED

Post-translational modifications for NLRP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NLRP10 (NLRP10/Pynod/NALP10)

No data available for DME Specific Peptides for NLRP10 Gene

Domains & Families for NLRP10 Gene

Gene Families for NLRP10 Gene

Protein Domains for NLRP10 Gene

Suggested Antigen Peptide Sequences for NLRP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W26

UniProtKB/Swiss-Prot:

NAL10_HUMAN :
  • The pyrin and ATP-binding domains are required to elicit cytokine release following bacterial infection.
  • Belongs to the NLRP family.
Domain:
  • The pyrin and ATP-binding domains are required to elicit cytokine release following bacterial infection.
  • The NACHT domain is required for inhibition of CASP1 autoprocessing.
  • Contains 1 NACHT domain.
  • Contains 1 pyrin domain.
Family:
  • Belongs to the NLRP family.
genes like me logo Genes that share domains with NLRP10: view

Function for NLRP10 Gene

Molecular function for NLRP10 Gene

UniProtKB/Swiss-Prot Function:
Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.
genes like me logo Genes that share phenotypes with NLRP10: view

Animal Models for NLRP10 Gene

MGI Knock Outs for NLRP10:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NLRP10 Gene

Localization for NLRP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRP10 Gene

Cytoplasm. Cell membrane. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLRP10 Gene COMPARTMENTS Subcellular localization image for NLRP10 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for NLRP10 Gene

Pathways & Interactions for NLRP10 Gene

genes like me logo Genes that share pathways with NLRP10: view

Pathways by source for NLRP10 Gene

1 BioSystems pathway for NLRP10 Gene

Interacting Proteins for NLRP10 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000327763%0d%0a9606.ENSP00000363822%0d%0a9606.ENSP00000275493%0d%0a
Selected Interacting proteins: ENSP00000327763 Q86W26-NAL10_HUMAN for NLRP10 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NLRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002827 positive regulation of T-helper 1 type immune response IEA,ISS --
GO:0035397 helper T cell enhancement of adaptive immune response IEA,ISS --
GO:0036336 dendritic cell migration IEA,ISS --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with NLRP10: view

No data available for SIGNOR curated interactions for NLRP10 Gene

Drugs & Compounds for NLRP10 Gene

No Compound Related Data Available

Transcripts for NLRP10 Gene

mRNA/cDNA for NLRP10 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NLRP10 Gene

NLR family, pyrin domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP10 Gene

No ASD Table

Relevant External Links for NLRP10 Gene

GeneLoc Exon Structure for
NLRP10
ECgene alternative splicing isoforms for
NLRP10

Expression for NLRP10 Gene

mRNA expression in normal human tissues for NLRP10 Gene

mRNA differential expression in normal tissues according to GTEx for NLRP10 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x24.1) and Skin - Not Sun Exposed (Suprapubic) (x16.9).

Protein differential expression in normal tissues from HIPED for NLRP10 Gene

This gene is overexpressed in Bone (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NLRP10 Gene



SOURCE GeneReport for Unigene cluster for NLRP10 Gene Hs.449636

mRNA Expression by UniProt/SwissProt for NLRP10 Gene

Q86W26-NAL10_HUMAN
Tissue specificity: Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis. Little expression detected in myeloid cells or peripheral blood mononuclear cells.
genes like me logo Genes that share expression patterns with NLRP10: view

Protein tissue co-expression partners for NLRP10 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NLRP10 Gene

Orthologs for NLRP10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP10 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NLRP10 35
  • 80.55 (n)
  • 71.92 (a)
NLRP10 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nlrp10 35
  • 75.03 (n)
  • 62.38 (a)
Nlrp10 16
Nlrp10 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NLRP10 35
  • 99.44 (n)
  • 99.23 (a)
NLRP10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nlrp10 35
  • 75.16 (n)
  • 63.71 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 16 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia NLRP10 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NLRP10 36
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 14 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CU693495.1 36
  • 18 (a)
ManyToMany
nlrb5 36
  • 18 (a)
ManyToMany
si:ch211-66k16.2 36
  • 21 (a)
ManyToMany
si:ch211-66k16.28 36
  • 11 (a)
ManyToMany
Species with no ortholog for NLRP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NLRP10 Gene

ENSEMBL:
Gene Tree for NLRP10 (if available)
TreeFam:
Gene Tree for NLRP10 (if available)

Paralogs for NLRP10 Gene

(4) SIMAP similar genes for NLRP10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NLRP10: view

Variants for NLRP10 Gene

Sequence variations from dbSNP and Humsavar for NLRP10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs988455 -- 7,961,505(-) ACTGC(A/G)CCTGC intron-variant
rs1397591 -- 7,967,025(-) attcc(G/T)ccctt upstream-variant-2KB
rs1858279 -- 7,965,800(-) AGGAT(A/G)TGGTG upstream-variant-2KB
rs11608118 -- 7,959,974(+) AAATG(C/T)TTCAG reference, synonymous-codon
rs11822405 -- 7,965,358(+) CCTGG(C/T)CCGAC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NLRP10 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241

Variation tolerance for NLRP10 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NLRP10 Gene

Human Gene Mutation Database (HGMD)
NLRP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP10 Gene

Disorders for NLRP10 Gene

Relevant External Links for NLRP10

Genetic Association Database (GAD)
NLRP10
Human Genome Epidemiology (HuGE) Navigator
NLRP10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NLRP10

No disorders were found for NLRP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP10 Gene

Publications for NLRP10 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4 67
  2. Roles of NLRP10 in innate and adaptive immunity. (PMID: 23562614) Damm A. … Kufer T.A. (Microbes Infect. 2013) 3
  3. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PMID: 23956138) Foerster S. … Ritter C.A. (Proteomics 2013) 3
  4. Functional characterization of the p53 binding site in the human PYNOD promoter. (PMID: 22365966) Zeng Q. … Hu C. (Hum. Immunol. 2012) 3
  5. NLRP10 enhances Shigella-induced pro-inflammatory responses. (PMID: 22672233) Lautz K. … Kufer T.A. (Cell. Microbiol. 2012) 3

Products for NLRP10 Gene

Sources for NLRP10 Gene

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