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Aliases for NLRP10 Gene

Aliases for NLRP10 Gene

  • NLR Family, Pyrin Domain Containing 10 2 3
  • NALP10 3 4 6
  • PYNOD 3 4 6
  • NOD8 3 4 6
  • Nucleotide-Binding Oligomerization Domain Protein 8 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 10 2 3
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 10 3
  • Leucine Rich Repeat And Pyrin Domain Containing 10 2
  • NACHT, LRR And PYD Domains-Containing Protein 10 3
  • Nucleotide-Binding Oligomerization Domain 2
  • CLR11.1 3
  • PAN5 3

External Ids for NLRP10 Gene

Previous Symbols for NLRP10 Gene

  • NALP10

Summaries for NLRP10 Gene

Entrez Gene Summary for NLRP10 Gene

  • Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for NLRP10 Gene

NLRP10 (NLR Family, Pyrin Domain Containing 10) is a Protein Coding gene. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. An important paralog of this gene is NLRC3.

UniProtKB/Swiss-Prot for NLRP10 Gene

  • Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.

Gene Wiki entry for NLRP10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP10 Gene

Genomics for NLRP10 Gene

Genomic Location for NLRP10 Gene

Start:
7,959,424 bp from pter
End:
7,965,426 bp from pter
Size:
6,003 bases
Orientation:
Minus strand

Genomic View for NLRP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLRP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP10 Gene

Regulatory Elements for NLRP10 Gene

Proteins for NLRP10 Gene

  • Protein details for NLRP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W26-NAL10_HUMAN
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 10
    Protein Accession:
    Q86W26
    Secondary Accessions:
    • Q2M3C4
    • Q6JGT0

    Protein attributes for NLRP10 Gene

    Size:
    655 amino acids
    Molecular mass:
    75032 Da
    Quaternary structure:
    • Oligomerizes. Interacts with PYCARD, CASP1 and IL1B. Also interacts with NOD1 and components of the NOD1 signaling pathway including RIPK2, NR2C2/TAK1 and IKBKG/NEMO.

    Three dimensional structures from OCA and Proteopedia for NLRP10 Gene

neXtProt entry for NLRP10 Gene

Proteomics data for NLRP10 Gene at MOPED

Post-translational modifications for NLRP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NLRP10 Gene

Domains for NLRP10 Gene

Gene Families for NLRP10 Gene

HGNC:
  • NLR :Nucleotide-binding domain and leucine rich repeat containing
IUPHAR :

Protein Domains for NLRP10 Gene

UniProtKB/Swiss-Prot:

NAL10_HUMAN
Domain:
  • The DAPIN and ATP-binding domains are required to elicit cytokine release following bacterial infection:
    • Q86W26
  • The NACHT domain is required for inhibition of CASP1 autoprocessing:
    • Q86W26
  • Contains 1 DAPIN domain.:
    • Q86W26
  • Contains 1 NACHT domain.:
    • Q86W26
Family:
  • Belongs to the NLRP family.:
    • Q86W26
genes like me logo Genes that share domains with NLRP10: view

Function for NLRP10 Gene

Molecular function for NLRP10 Gene

UniProtKB/Swiss-Prot Function: Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.

Gene Ontology (GO) - Molecular Function for NLRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRP10: view

Phenotypes for NLRP10 Gene

genes like me logo Genes that share phenotypes with NLRP10: view

Animal Models for NLRP10 Gene

MGI Knock Outs for NLRP10:

miRNA for NLRP10 Gene

miRTarBase miRNAs that target NLRP10

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NLRP10 Gene

Localization for NLRP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRP10 Gene

Cytoplasm. Cell membrane. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLRP10 Gene COMPARTMENTS Subcellular localization image for NLRP10 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for NLRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22672233
GO:0019897 extrinsic component of plasma membrane IDA 22672233
genes like me logo Genes that share ontologies with NLRP10: view

Pathways for NLRP10 Gene

genes like me logo Genes that share pathways with NLRP10: view

Pathways by source for NLRP10 Gene

1 BioSystems pathway for NLRP10 Gene

Interacting Proteins for NLRP10 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000327763%0d%0a9606.ENSP00000363822%0d%0a9606.ENSP00000275493%0d%0a
Selected Interacting proteins: ENSP00000327763 Q86W26-NAL10_HUMAN for NLRP10 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NLRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002827 positive regulation of T-helper 1 type immune response ISS --
GO:0035397 helper T cell enhancement of adaptive immune response ISS --
GO:0036336 dendritic cell migration ISS --
GO:0045087 innate immune response IEA --
GO:0050829 defense response to Gram-negative bacterium IMP 22672233
genes like me logo Genes that share ontologies with NLRP10: view

Transcripts for NLRP10 Gene

mRNA/cDNA for NLRP10 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NLRP10 Gene

NLR family, pyrin domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP10 Gene

No ASD Table

Relevant External Links for NLRP10 Gene

GeneLoc Exon Structure for
NLRP10
ECgene alternative splicing isoforms for
NLRP10

Expression for NLRP10 Gene

mRNA expression in normal human tissues for NLRP10 Gene

mRNA differential expression in normal tissues according to GTEx for NLRP10 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (24.1) and Skin - Not Sun Exposed (Suprapubic) (16.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NLRP10 Gene

SOURCE GeneReport for Unigene cluster for NLRP10 Gene Hs.449636

mRNA Expression by UniProt/SwissProt for NLRP10 Gene

Q86W26-NAL10_HUMAN
Tissue specificity: Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis. Little expression detected in myeloid cells or peripheral blood mononuclear cells.
genes like me logo Genes that share expressions with NLRP10: view

Orthologs for NLRP10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRP10 36
  • 99.44 (n)
  • 99.23 (a)
NLRP10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 16 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia NLRP10 36
  • 80.55 (n)
  • 71.92 (a)
NLRP10 37
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nlrp10 36
  • 75.03 (n)
  • 62.38 (a)
Nlrp10 16
Nlrp10 37
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NLRP10 37
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NLRP10 37
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nlrp10 36
  • 75.16 (n)
  • 63.71 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 14 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CU693495.1 37
  • 18 (a)
ManyToMany
nlrb5 37
  • 18 (a)
ManyToMany
si:ch211-66k16.2 37
  • 21 (a)
ManyToMany
si:ch211-66k16.28 37
  • 11 (a)
ManyToMany
Species with no ortholog for NLRP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NLRP10 Gene

ENSEMBL:
Gene Tree for NLRP10 (if available)
TreeFam:
Gene Tree for NLRP10 (if available)

Paralogs for NLRP10 Gene

Paralogs for NLRP10 Gene

Selected SIMAP similar genes for NLRP10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NLRP10: view

Variants for NLRP10 Gene

Sequence variations from dbSNP and Humsavar for NLRP10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs988455 -- 7,961,505(-) ACTGC(A/G)CCTGC intron-variant
rs9919582 -- 7,961,652(+) GCAAG(C/T)GTGTG intron-variant
rs9919613 -- 7,961,621(+) TTGTG(C/G)AGGGA intron-variant
rs10684087 -- 7,963,796(+) CTCTC(-/TCCT/TCTC)CCCCA upstream-variant-2KB
rs10769857 -- 7,959,165(+) GCACC(A/G)TTTGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NLRP10 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241

Relevant External Links for NLRP10 Gene

HapMap Linkage Disequilibrium report
NLRP10
Human Gene Mutation Database (HGMD)
NLRP10

Disorders for NLRP10 Gene

Relevant External Links for NLRP10

Genetic Association Database (GAD)
NLRP10
Human Genome Epidemiology (HuGE) Navigator
NLRP10
genes like me logo Genes that share disorders with NLRP10: view

No data available for UniProtKB/Swiss-Prot for NLRP10 Gene

Publications for NLRP10 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4
  2. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N. … Nunez G. (Nat. Rev. Immunol. 2003) 3 4
  3. PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1. (PMID: 15096476) Wang Y. … Suda T. (Int. Immunol. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Anti-inflammatory activity of PYNOD and its mechanism in humans and mice. (PMID: 20393137) Imamura R. … Suda T. (J. Immunol. 2010) 3 4

Products for NLRP10 Gene

Sources for NLRP10 Gene

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