NLRP1 Gene
protein-coding GIFtS: 60
GCID: GC17M005407
|
|
NLR family, pyrin domain containing 1(Previous names: NACHT, leucine rich repeat and PYD (pyrin domain) containing...)
(Previous symbol: NALP1)
| |
Aliases
for NLRP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NLR Family, Pyrin Domain Containing 11 2 | | SLEV12 5 | | CARD71 2 3 5 | | VAMAS12 5 | | DEFCAP1 2 3 5 | | DKFZp586O18221 | | NALP11 2 3 5 | | DEFCAP-L/S2 | | NAC1 2 3 | | PP10442 | | KIAA09261 3 5 | | Caspase Recruitment Domain Protein 72 | | CLR17.11 2 | | NACHT, Leucine Rich Repeat And PYD Containing 12 | | NACHT, Leucine Rich Repeat And PYD (Pyrin Domain) Containing 11 2 | | NACHT, LRR And PYD Containing Protein 12 | | Caspase Recruitment Domain-Containing Protein 72 3 | | NACHT, LRR And PYD Domains-Containing Protein 12 | | Death Effector Filament-Forming Ced-4-Like Apoptosis Protein2 3 | | Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin DomainContaining 12 | | Nucleotide-Binding Domain And Caspase Recruitment Domain2 3 | | |
Export aliases for NLRP1 gene to outside databasesPrevious GC identifers: GC17M005351 GC17M005354 GC17M005357 GC17M005294 |
Summaries
for NLRP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NLRP1:
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitmentdomain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinctN-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interactsstrongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis incells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene,but the biological validity of some variants has not been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NALP1_HUMAN, Q9C000Function: Able to form cytoplasmic structures termed death effector filaments. Enhances APAF1 and cytochromec-dependent activation of pro-caspase-9 and consecutive apoptosis. Stimulates apoptosis through activation ofcaspase-3. Involved in activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads toprocessing and release of IL1B and IL18. Binds ATP
Gene Wiki entry for NLRP1
|
Genomic Views
for NLRP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NLRP1 gene promoter:
NRSF form 1 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NLRP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLRP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13NLRP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M005407: view genomic region
(about GC identifiers)
Start:
|
5,402,747 bp from pter |
End:
|
5,522,744 bp from pter |
Size:
|
119,998 bases |
Orientation:
|
minus strand |
|
Proteins
for NLRP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NALP1_HUMAN, Q9C000 (See
protein sequence)Recommended Name: NACHT, LRR and PYD domains-containing protein 1 Size: 1473 amino acids; 165866 Da
Subunit: Interacts strongly with caspase-2, weakly with caspase-9 and with APAF1 in a cytochrome c-inducible way,leading to the formation of an apoptosome. This interaction may be ATP-dependent. Part of the NALP1 inflammasomecomplex which is involved in activation of caspase-1 and caspase-5, leading to processing of IL1B and IL18. Thecomplex is activated by bacterial muramyl dipeptide which triggers ATP-binding and oligomerization of NALP1
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=BAA76770.2; Type=Erroneous initiation;
2 PDB 3D structures from  and Proteopedia  for NLRP1:1PN5 (3D)
3KAT (3D)
Secondary accessions: Q9BZZ8 Q9BZZ9 Q9HAV8 Q9UFT4 Q9Y2E0Alternative splicing: 4 isoforms: Q9C000-1 Q9C000-2 Q9C000-3 Q9C000-4 Explore the universe of human proteins at neXtProt for NLRP1: NX_Q9C000
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9C000
NLRP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001028225.1 NP_055737.1 NP_127497.1 NP_127499.1 NP_127500.1
ENSEMBL proteins: ENSP00000442029 ENSP00000262467 ENSP00000459661 ENSP00000269280 ENSP00000460475 ENSP00000346390 ENSP00000460216 ENSP00000458303 ENSP00000324366 Reactome Protein details: Q9C000
Human Recombinant Protein Products for NLRP1:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
NLRP1 for ontologies About GeneDecksing
NLRP1 Antibody Products:
Assay Products for NLRP1: |
Protein
Domains /
Families
for NLRP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NLRP1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9C000ProtoNet protein and cluster: Q9C000 3 Blocks protein families: IPB000767 Disease resistance protein signature IPB001315 CARD interaction domain IPB004020 Pyrin domain
UniProtKB/Swiss-Prot: NALP1_HUMAN, Q9C000Similarity: Belongs to the NLRP familySimilarity: Contains 1 CARD domainSimilarity: Contains 1 DAPIN domainSimilarity: Contains 6 LRR (leucine-rich) repeatsSimilarity: Contains 1 NACHT domain |
Function
for NLRP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NALP1_HUMAN, Q9C000Function: Able to form cytoplasmic structures termed death effector filaments. Enhances APAF1 and cytochromec-dependent activation of pro-caspase-9 and consecutive apoptosis. Stimulates apoptosis through activation ofcaspase-3. Involved in activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads toprocessing and release of IL1B and IL18. Binds ATP Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
NLRP1 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLRP1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLRP1 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): NLRP1 (NM_033004) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NLRP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLRP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRP1 |
|
Pathways & Interactions
for NLRP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | NLRP1 oligomerizes | | | 2 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | | | 3 | Immune System | | | 4 | NF-kappaB Signaling | | | 5 | Apoptosis and Autophagy | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for NLRP1
2  BioSystems Pathways for NLRP1
5/7 
Reactome Pathways for NLRP1 (see all 7)
1 
Kegg Pathway (Kegg details for NLRP1):
NLRP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NLRP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/16 Interacting proteins for NLRP1 (Q9C0001, 3 ENSP000002692804) via UniProtKB, MINT, STRING, and/or I2D (see all 16)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PYCARD | Q9ULZ31, 3, ENSP000002474704 | EBI-1220518,EBI-751215 I2D:
score=3 STRING: ENSP00000247470 | | BCL2 | P104151, 3, ENSP000003296234 | EBI-1220518,EBI-77694 I2D:
score=2 STRING: ENSP00000329623 | | BCL2L1 | Q078171, 3, ENSP000003025644 | EBI-1220518,EBI-78035 I2D:
score=2 STRING: ENSP00000302564 | | CASP2 | P425753, ENSP000003126644 | I2D:
score=3 STRING: ENSP00000312664 | | APAF1 | O147273, ENSP000003530594 | I2D:
score=2 STRING: ENSP00000353059 |
About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006917 | induction of apoptosis |
NAS | 11076957 | | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
NAS | 11076957 | | GO:0006952 | defense response |
-- | -- | | GO:0032495 | response to muramyl dipeptide |
ISS | -- | | GO:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
TAS | -- |
NLRP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NLRP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NLRP1
Search CenterWatch for drugs/clinical trials and news about NLRP1 / NALP1
|
Transcripts
for NLRP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NLRP1 gene (5 alternative transcripts): NM_001033053.2 NM_014922.4 NM_033004.3 NM_033006.3 NM_033007.3 Unigene Cluster for NLRP1: NLR family, pyrin domain containing 1 Hs.652273 [show with all ESTs]Unigene Representative Sequence: NM_03300414 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000544378 ENST00000574406 ENST00000568641(uc010vtc.2) ENST00000262467(uc002gcg.1)
ENST00000574512 ENST00000571451 ENST00000269280 ENST00000572272 ENST00000354411
ENST00000577119 ENST00000571307(uc010clh.3) ENST00000576905 ENST00000572143
ENST00000345221(uc002gci.3 uc002gch.4 uc002gck.3 uc002gcj.3 uc002gcl.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLRP1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLRP1 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): NLRP1 (NM_033004) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NLRP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLRP1 |
Additional cDNA sequence: AB023143.1 AF229059.1 AF229060.1 AF229061.1 AF229062.1 AF298548.1 AF310105.1 AK026393.1 AK026398.1 AK310936.1 AL117470.1 AL832400.1 BX538292.1 13 DOTS entries: DT.407800 DT.408674 DT.100023665 DT.100864401 DT.100846796 DT.100864405 DT.100864399 DT.444893 DT.95071725 DT.120947087 DT.40254982 DT.120947079 DT.97794726 24/395 AceView cDNA sequences (see all 395): CR623524 CD107219 BE382901 BX341135 AI338579 BM759667 CD107655 AA971909 AL117470 BM671397 CR620726 CA447361 CR612487 BF059271 AL601917 BM722905 AA836083 CA308213 AA913016 NM_014922 CR614765 BQ639913 AF229061 AF310105
GeneLoc Exon Structure
|
Expression
for NLRP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NLRP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAATAACTT
About this image
See NLRP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NLRP1
SOURCE GeneReport for Unigene cluster: Hs.652273
UniProtKB/Swiss-Prot: NALP1_HUMAN, Q9C000Tissue specificity: Widely expressed. Isoform 1 and isoform 2 are expressed in peripheral blood leukocytes and chronicmyelogenous leukemia cell line K-562, followed by thymus, spleen and heart. Also detected in brain, lung, placenta,small intestine, colon, kidney, liver, muscle, testis and epithelial cells. Absent from hematopoietic progenitor cellsbut expressed upon differentiation of cells into granulocytes and, to a lesser extent, monocytes. In peripheral bloodcells, highest levels are found in T-lymphocytes, granulocytes and monocytes. Expression is significantly increased inbone marrow blast cells of some acute leukemia patients but not in solid tumors
SABiosciences Expression via Pathway-Focused PCR Arrays including NLRP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLRP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NLRP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLRP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLRP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRP1 |
Orthologs
for NLRP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NLRP1 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for NLRP1 (if available)
TreeFam Gene Tree for NLRP1 (if available) |
Paralogs
for NLRP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NLRP1 gene
- NLRP132 NLRP42 NLRP92 NLRP62 NLRP32 NLRP142 NLRP72 NLRP112
- NLRP102 NLRP22 NLRP52 NLRP82 NLRP122
11 SIMAP similar genes for NLRP1 using alignment to 6 protein entries: NALP1_HUMAN (see all proteins):CIAS1 NLRP2 CARD8 RNH1 DKFZp686B22249 NLRP3
NLRP12 PYCARD NLRP14 PP1579 NLRP10
NLRP1 for paralogs About GeneDecksing
|
Genomic Variants
for NLRP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NLRP1 (5402747 - 5522744 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NLRP1
2 Indels: 40160 25884
Human Gene Mutation Database (HGMD): NLRP1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLRP1 |
|
Disorders
/ Diseases
for NLRP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NLRP1 for disorders About GeneDecksing
OMIM gene information: 606636
OMIM disorders: 606579
UniProtKB/Swiss-Prot: NALP1_HUMAN, Q9C000
Genetic variations in NLRP1 are associated with susceptibility to vitiligo (VTLG) [MIM:193200]. VTLG is apigmentary disorder of the skin characterized by circumscribed depigmented macules and patches, commonly on extensoraspects of extremities, on the face or neck and in skin folds. It is a progressive disorder in which some or all ofthe melanocytes in the affected skin are selectively destroyed. It is a multifactorial disorder with a complexetiology probably including autoimmune mechanisms, and is associated with an elevated risk of other autoimmunediseases Genetic variations in NLRP1 gene are associated with susceptibility to vitiligo-associated multiple autoimmunedisease type 1 (VAMAS1) [MIM:606579]. VAMAS1 is an autoimmune disorder characterized by the association of vitiligowith several autoimmune and autoinflammatory diseases including autoimmune thyroid disease, rheumatoid arthritis andsystemic lupus erythematosus
20/22  diseases for NLRP1 (see all 22): About MalaCardsvitiligo-associated multiple autoimmune disease susceptibility 1 spinal cord injury toxic encephalopathy vitiligo
systemic lupus erythematosus gastrointestinal system disease lupus erythematosus inflammatory bowel disease
atopic dermatitis chronic lymphocytic leukemia lymphocytic leukemia addison's disease
celiac disease rheumatoid arthritis dermatitis crohn's disease
parkinson's disease acute leukemia leukemia arthritis
1 disease from the University of Copenhagen DISEASES database for NLRP1:Vitiligo Human Genome Epidemiology (HuGE) Navigator: NLRP1 (21 documents)
Export disorders for NLRP1 gene to outside databases
|
Publications
for NLRP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NLRP1 gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with NLRP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Inflammasome components NALP 1 and 3 Show distinct but separate Expression profiles in human tissues suggesting a site-specific role in the inflammatory response. (PubMed id 17164409)1, 2, 9 Kummer J.A.... Tschopp J. (2007)
- Expression of NALP1 in cerebellar granule neurons stimulates apoptosis. (PubMed id 15212762)1, 2, 9 Liu F.... Ozenberger B.A. (2004)
- Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. (PubMed id 11076957)1, 2, 9 Hlaing T.... Ward P.A. (2001)
- NALPs: a novel protein family involved in inflammation. (PubMed id 12563287)1, 3, 9 Tschopp J....Burns K. (2003)
- NALP1 in vitiligo-associated multiple autoimmune disease. (PubMed id 17377159)1, 2 Jin Y.... Spritz R.A. (2007)
- NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. (PubMed id 14527388)1, 2 Hiller S.... Wuethrich K. (2003)
- The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. (PubMed id 12191486)1, 2 Martinon F.... Tschopp J. (2002)
- The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. (PubMed id 11250163)1, 2 Martinon F.... Tschopp J. (2001)
- A novel enhancer of the Apaf1 apoptosome involved in cytochrome c- dependent caspase activation and apoptosis. (PubMed id 11113115)1, 2 Chu Z.-L.... Reed J.C. (2001)
- The PYRIN domain: a novel motif found in apoptosis and inflammation proteins. (PubMed id 11270363)1, 2 Bertin J. and DiStefano P.S. (2000)
|
External Searches for NLRP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NLRP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NLRP1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing NLRP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NLRP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NLRP1 gene:
Search GeneIP for patents involving NLRP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NLRP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for NLRP1 | | OriGene shRNA RFP for NLRP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NLRP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLRP1 | | | OriGene Protein Over-expression Lysate for NLRP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NLRP1 | | OriGene 3'-UTR Clone for NLRP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLRP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLRP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NLRP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NLRP1 | | OriGene Custom Protein Services for NLRP1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NLRP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLRP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLRP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NLRP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLRP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLRP1 |
| |
 |  |  |  | |
| | Antibodies & Assays for NLRP1 (NALP1) |
| | | | Search Tocris compounds for NLRP1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | NLRP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRP1 |
|  |  |  |  | | | | ThermoFisher Antibodies for NLRP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLRP1 |
| |  | |
|
|
|
