Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NLRC5 Gene

Aliases for NLRC5 Gene

  • NLR Family CARD Domain Containing 5 2 3 5
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 5 2 3
  • Nucleotide-Binding Oligomerization Domain Protein 4 3 4
  • Caterpiller Protein 16.1 3 4
  • NOD-Like Receptor C5 2 3
  • CLR16.1 3 4
  • NOD27 3 4
  • NOD4 3 4
  • Nucleotide-Binding Oligomerization Domain Protein 27 4
  • Nucleotide-Binding Oligomerization Domains 27 3
  • Protein NLRC5 3

External Ids for NLRC5 Gene

Previous GeneCards Identifiers for NLRC5 Gene

  • GC16P055581
  • GC16P042892

Summaries for NLRC5 Gene

Entrez Gene Summary for NLRC5 Gene

  • This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]

GeneCards Summary for NLRC5 Gene

NLRC5 (NLR Family CARD Domain Containing 5) is a Protein Coding gene. Diseases associated with NLRC5 include Acute Endometritis and Endometrial Disease. Among its related pathways are Innate Immune System and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is CIITA.

UniProtKB/Swiss-Prot for NLRC5 Gene

  • Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.

Gene Wiki entry for NLRC5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRC5 Gene

Genomics for NLRC5 Gene

Regulatory Elements for NLRC5 Gene

Enhancers for NLRC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G056964 1.3 Ensembl ENCODE 39.9 -24.1 -24091 2.5 HDGF CREB3L1 ARNT ARID4B DMAP1 SLC30A9 ZNF207 ZNF143 FOS KLF13 NLRC5 RSPRY1 HERPUD1 NUP93 FAM192A NUDT21 POLR2C GC16M056955 GC16M056973
GH16G057035 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21 +50.0 50046 8.5 HDGF PKNOX1 ZNF133 YBX1 ZNF143 FOS JUNB REST ZNF623 TBX21 NLRC5 CETP LOC100130044 MT1E FAM192A GC16P057038 GC16P057053
GH16G056950 1.5 Ensembl ENCODE dbSUPER 22.5 -38.0 -37964 1.3 HDGF ZFP64 ARID4B ZNF2 ZNF48 GLIS2 ZNF143 FOS DEK ZNF263 NLRC5 GC16M056953 ENSG00000261114
GH16G057013 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +25.1 25103 3.2 HDGF TBP PKNOX1 ZFP64 RAD21 RELB ETV6 IKZF2 CREM CBFB NLRC5 NUP93 NUDT21 HERPUD1 LOC100130044 GC16P057038
GH16G056971 0.9 ENCODE 23.6 -18.0 -18030 0.9 ELF3 HDGF PKNOX1 ARID4B THRB RELB IKZF2 CREM THAP11 SP5 NLRC5 HERPUD1 FAM192A RSPRY1 GC16M056973 GC16M056955
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NLRC5 on UCSC Golden Path with GeneCards custom track

Promoters for NLRC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000086355 315 1601 HDGF MLX WRNIP1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF263 MXD4

Genomic Location for NLRC5 Gene

Chromosome:
16
Start:
56,989,485 bp from pter
End:
57,083,531 bp from pter
Size:
94,047 bases
Orientation:
Plus strand

Genomic View for NLRC5 Gene

Genes around NLRC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRC5 Gene

Proteins for NLRC5 Gene

  • Protein details for NLRC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WI3-NLRC5_HUMAN
    Recommended name:
    Protein NLRC5
    Protein Accession:
    Q86WI3
    Secondary Accessions:
    • B5MEF1
    • C9JMD8
    • Q6P4A6
    • Q86VM7
    • Q8NF42
    • Q8TEE2
    • Q8TEJ1
    • Q969L7

    Protein attributes for NLRC5 Gene

    Size:
    1866 amino acids
    Molecular mass:
    204595 Da
    Quaternary structure:
    • Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity. Interacts with DDX58 and IFIH1; blocks the interaction of MAVS to DDX58.
    SequenceCaution:
    • Sequence=BAB55096.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55098.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB85008.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NLRC5 Gene

neXtProt entry for NLRC5 Gene

Post-translational modifications for NLRC5 Gene

  • Ubiquitination at posLast=989989, posLast=10991099, and Lys1349
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NLRC5 Gene

Domains & Families for NLRC5 Gene

Gene Families for NLRC5 Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for NLRC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WI3

UniProtKB/Swiss-Prot:

NLRC5_HUMAN :
  • Belongs to the NLRP family.
Family:
  • Belongs to the NLRP family.
genes like me logo Genes that share domains with NLRC5: view

Function for NLRC5 Gene

Molecular function for NLRC5 Gene

UniProtKB/Swiss-Prot Function:
Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma.

Gene Ontology (GO) - Molecular Function for NLRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA 20639463
GO:0005515 protein binding IPI 20434986
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRC5: view

Phenotypes for NLRC5 Gene

genes like me logo Genes that share phenotypes with NLRC5: view

Animal Models for NLRC5 Gene

MGI Knock Outs for NLRC5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NLRC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NLRC5 Gene

Localization for NLRC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRC5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NLRC5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for NLRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20639463
GO:0005737 cytoplasm IDA,IEA 20061403
GO:0005813 centrosome IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NLRC5: view

Pathways & Interactions for NLRC5 Gene

genes like me logo Genes that share pathways with NLRC5: view

Gene Ontology (GO) - Biological Process for NLRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 20434986
GO:0032480 negative regulation of type I interferon production TAS --
GO:0043549 regulation of kinase activity IDA 20434986
GO:0045087 innate immune response IMP 20434986
genes like me logo Genes that share ontologies with NLRC5: view

No data available for SIGNOR curated interactions for NLRC5 Gene

Drugs & Compounds for NLRC5 Gene

No Compound Related Data Available

Transcripts for NLRC5 Gene

Unigene Clusters for NLRC5 Gene

NLR family, CARD domain containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NLRC5

Alternative Splicing Database (ASD) splice patterns (SP) for NLRC5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^
SP1: -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46a ·
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

ExUns: 46b · 46c ^ 47 ^ 48a · 48b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NLRC5 Gene

GeneLoc Exon Structure for
NLRC5
ECgene alternative splicing isoforms for
NLRC5

Expression for NLRC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NLRC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRC5 Gene

This gene is overexpressed in Whole Blood (x10.1) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for NLRC5 Gene

This gene is overexpressed in Lung (42.1) and Monocytes (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NLRC5 Gene



Protein tissue co-expression partners for NLRC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NLRC5 Gene:

NLRC5

SOURCE GeneReport for Unigene cluster for NLRC5 Gene:

Hs.528836

mRNA Expression by UniProt/SwissProt for NLRC5 Gene:

Q86WI3-NLRC5_HUMAN
Tissue specificity: Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate.

Evidence on tissue expression from TISSUES for NLRC5 Gene

  • Spleen(4.5)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with NLRC5: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NLRC5 Gene

Orthologs for NLRC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRC5 34
  • 96.65 (n)
dog
(Canis familiaris)
Mammalia NLRC5 34 35
  • 81.53 (n)
cow
(Bos Taurus)
Mammalia NLRC5 34 35
  • 81.51 (n)
mouse
(Mus musculus)
Mammalia Nlrc5 34 16 35
  • 70.59 (n)
oppossum
(Monodelphis domestica)
Mammalia NLRC5 35
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NLRC5 35
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves NLRC5 34 35
  • 52.9 (n)
lizard
(Anolis carolinensis)
Reptilia NLRC5 35
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730474 34
  • 47.13 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-122c9.5 34
  • 42.74 (n)
NLRC5 35
  • 28 (a)
OneToOne
Species where no ortholog for NLRC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NLRC5 Gene

ENSEMBL:
Gene Tree for NLRC5 (if available)
TreeFam:
Gene Tree for NLRC5 (if available)

Paralogs for NLRC5 Gene

Variants for NLRC5 Gene

Sequence variations from dbSNP and Humsavar for NLRC5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_036388 A breast cancer sample
rs199475959 untested 56,988,649(+) GCAGG(A/G)GAGCA upstream-variant-2KB
rs199475960 untested 56,988,660(+) CCAGC(A/G)GTCTG upstream-variant-2KB
rs199475961 untested 56,988,927(+) CTCCC(C/G/T)CTTTC upstream-variant-2KB
rs199475962 untested 56,989,205(+) TCCCC(C/T)CTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NLRC5 Gene

Variant ID Type Subtype PubMed ID
esv1010488 CNV gain 20482838
esv1676058 CNV insertion 17803354
esv2132758 CNV deletion 18987734
esv2254792 CNV deletion 18987734
esv2675650 CNV deletion 23128226
esv2714520 CNV deletion 23290073
esv2714521 CNV deletion 23290073
esv2714522 CNV deletion 23290073
esv2714523 CNV deletion 23290073
nsv1059098 CNV gain 25217958
nsv1113810 CNV deletion 24896259
nsv1117164 CNV tandem duplication 24896259
nsv572697 CNV loss 21841781
nsv827683 CNV loss 20364138

Variation tolerance for NLRC5 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.84; 73.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NLRC5 Gene

Human Gene Mutation Database (HGMD)
NLRC5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NLRC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRC5 Gene

Disorders for NLRC5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NLRC5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute endometritis
endometrial disease
  • endometrial disorder
- elite association - COSMIC cancer census association via MalaCards
Search NLRC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NLRC5

Genetic Association Database (GAD)
NLRC5
Human Genome Epidemiology (HuGE) Navigator
NLRC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NLRC5
genes like me logo Genes that share disorders with NLRC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NLRC5 Gene

Publications for NLRC5 Gene

  1. Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. (PMID: 12615073) Dowds T.A. … Nunez G. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 64
  2. Unusual structural features revealed by the solution NMR structure of the NLRC5 caspase recruitment domain. (PMID: 24815518) Gutte P.G. … Zerbe O. (Biochemistry 2014) 2 3 64
  3. NLRC5: a key regulator of MHC class I-dependent immune responses. (PMID: 23175229) Kobayashi K.S. … van den Elsen P.J. (Nat. Rev. Immunol. 2012) 2 3 64
  4. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G. … Boerwinkle E. (PLoS Genet. 2011) 3 46 64
  5. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 46 64

Products for NLRC5 Gene

  • Addgene plasmids for NLRC5

Sources for NLRC5 Gene

Content
Loading form....