Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NLRC5 Gene

Aliases for NLRC5 Gene

  • NLR Family, CARD Domain Containing 5 2 3
  • Nucleotide-Binding Oligomerization Domain Protein 4 3 4
  • Caterpiller Protein 16.1 3 4
  • NOD-Like Receptor C5 2 3
  • CLR16.1 3 4
  • NOD27 3 4
  • NOD4 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 5 3
  • Nucleotide-Binding Oligomerization Domain Protein 27 4
  • Leucine Rich Repeat And CARD Domain Containing 5 2
  • Nucleotide-Binding Oligomerization Domains 27 3
  • Nucleotide-Binding Oligomerization Domain 2
  • Protein NLRC5 3

External Ids for NLRC5 Gene

Summaries for NLRC5 Gene

Entrez Gene Summary for NLRC5 Gene

  • This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]

GeneCards Summary for NLRC5 Gene

NLRC5 (NLR Family, CARD Domain Containing 5) is a Protein Coding gene. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is NLRX1.

UniProtKB/Swiss-Prot for NLRC5 Gene

  • Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.

Gene Wiki entry for NLRC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRC5 Gene

Genomics for NLRC5 Gene

Genomic Location for NLRC5 Gene

Start:
56,989,485 bp from pter
End:
57,083,531 bp from pter
Size:
94,047 bases
Orientation:
Plus strand

Genomic View for NLRC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLRC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRC5 Gene

Regulatory Elements for NLRC5 Gene

Proteins for NLRC5 Gene

  • Protein details for NLRC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WI3-NLRC5_HUMAN
    Recommended name:
    Protein NLRC5
    Protein Accession:
    Q86WI3
    Secondary Accessions:
    • B5MEF1
    • C9JMD8
    • Q6P4A6
    • Q86VM7
    • Q8NF42
    • Q8TEE2
    • Q8TEJ1
    • Q969L7

    Protein attributes for NLRC5 Gene

    Size:
    1866 amino acids
    Molecular mass:
    204595 Da
    Quaternary structure:
    • Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity. Interacts with DDX58 and IFIH1; blocks the interaction of MAVS to DDX58.
    SequenceCaution:
    • Sequence=BAB55096.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55098.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB85008.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NLRC5 Gene

neXtProt entry for NLRC5 Gene

Proteomics data for NLRC5 Gene at MOPED

Post-translational modifications for NLRC5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys989, Lys1099, and Lys1349

No data available for DME Specific Peptides for NLRC5 Gene

Domains for NLRC5 Gene

Gene Families for NLRC5 Gene

HGNC:
  • NLR :Nucleotide-binding domain and leucine rich repeat containing
IUPHAR :

Protein Domains for NLRC5 Gene

UniProtKB/Swiss-Prot:

NLRC5_HUMAN
Domain:
  • Contains 1 NACHT domain.:
    • Q86WI3
Family:
  • Belongs to the NLRP family.:
    • Q86WI3
Similarity:
  • Contains 26 LRR (leucine-rich) repeats.:
    • Q86WI3
genes like me logo Genes that share domains with NLRC5: view

Function for NLRC5 Gene

Molecular function for NLRC5 Gene

UniProtKB/Swiss-Prot Function: Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
UniProtKB/Swiss-Prot Induction: By IFNG/IFN-gamma.

Gene Ontology (GO) - Molecular Function for NLRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA 20639463
GO:0005515 protein binding IPI 20434986
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRC5: view

Phenotypes for NLRC5 Gene

genes like me logo Genes that share phenotypes with NLRC5: view

Animal Models for NLRC5 Gene

MGI Knock Outs for NLRC5:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NLRC5 Gene

Localization for NLRC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRC5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLRC5 Gene COMPARTMENTS Subcellular localization image for NLRC5 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for NLRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20639463
GO:0005737 cytoplasm IDA 20061403
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NLRC5: view

Pathways for NLRC5 Gene

genes like me logo Genes that share pathways with NLRC5: view

Pathways by source for NLRC5 Gene

Gene Ontology (GO) - Biological Process for NLRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 20434986
GO:0032480 negative regulation of type I interferon production TAS --
GO:0043549 regulation of kinase activity IDA 20434986
GO:0045087 innate immune response TAS --
GO:0045345 positive regulation of MHC class I biosynthetic process IDA 20639463
genes like me logo Genes that share ontologies with NLRC5: view

Transcripts for NLRC5 Gene

Unigene Clusters for NLRC5 Gene

NLR family, CARD domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NLRC5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^
SP1: -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46a ·
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

ExUns: 46b · 46c ^ 47 ^ 48a · 48b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NLRC5 Gene

GeneLoc Exon Structure for
NLRC5
ECgene alternative splicing isoforms for
NLRC5

Expression for NLRC5 Gene

mRNA expression in normal human tissues for NLRC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRC5 Gene

This gene is overexpressed in Whole Blood (10.1) and Spleen (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NLRC5 Gene

SOURCE GeneReport for Unigene cluster for NLRC5 Gene Hs.528836

mRNA Expression by UniProt/SwissProt for NLRC5 Gene

Q86WI3-NLRC5_HUMAN
Tissue specificity: Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate.
genes like me logo Genes that share expressions with NLRC5: view

Orthologs for NLRC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRC5 36
  • 96.65 (n)
  • 95.69 (a)
cow
(Bos Taurus)
Mammalia NLRC5 36
  • 81.51 (n)
  • 72.94 (a)
NLRC5 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NLRC5 36
  • 81.53 (n)
  • 74.61 (a)
NLRC5 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nlrc5 36
  • 70.59 (n)
  • 61.7 (a)
Nlrc5 16
Nlrc5 37
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NLRC5 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NLRC5 37
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves NLRC5 36
  • 52.9 (n)
  • 41.01 (a)
NLRC5 37
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NLRC5 37
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730474 36
  • 47.13 (n)
  • 36.36 (a)
zebrafish
(Danio rerio)
Actinopterygii NLRC5 37
  • 28 (a)
OneToOne
si:ch211-122c9.5 36
  • 42.74 (n)
  • 30.14 (a)
Species with no ortholog for NLRC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NLRC5 Gene

ENSEMBL:
Gene Tree for NLRC5 (if available)
TreeFam:
Gene Tree for NLRC5 (if available)

Paralogs for NLRC5 Gene

Paralogs for NLRC5 Gene

genes like me logo Genes that share paralogs with NLRC5: view

Variants for NLRC5 Gene

Sequence variations from dbSNP and Humsavar for NLRC5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs27191 -- 57,083,939(-) GCTGA(C/G)GCATG downstream-variant-500B
rs27192 -- 57,083,604(-) GTTTG(C/T)GCTGC downstream-variant-500B
rs27193 -- 57,083,493(-) ATCAA(A/G)CCTGG utr-variant-3-prime, nc-transcript-variant
rs27194 -- 57,082,602(+) GATAA(A/T)TGACT utr-variant-3-prime, nc-transcript-variant
rs27195 -- 57,082,375(-) CATCT(C/T)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLRC5 Gene

Variant ID Type Subtype PubMed ID
esv2676366 CNV Deletion 23128226
nsv827683 CNV Loss 20364138
esv1676058 CNV Insertion 17803354
esv1010488 CNV Gain 20482838
nsv906723 CNV Loss 21882294
esv2714520 CNV Deletion 23290073
esv2714521 CNV Deletion 23290073
esv2132758 CNV Deletion 18987734
esv2254792 CNV Deletion 18987734
esv2675650 CNV Deletion 23128226
esv2714522 CNV Deletion 23290073
esv2714523 CNV Deletion 23290073

Relevant External Links for NLRC5 Gene

HapMap Linkage Disequilibrium report
NLRC5
Human Gene Mutation Database (HGMD)
NLRC5

Disorders for NLRC5 Gene

(1) University of Copenhagen DISEASES for NLRC5 Gene

Relevant External Links for NLRC5

Genetic Association Database (GAD)
NLRC5
Human Genome Epidemiology (HuGE) Navigator
NLRC5
genes like me logo Genes that share disorders with NLRC5: view

No data available for UniProtKB/Swiss-Prot for NLRC5 Gene

Publications for NLRC5 Gene

  1. Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. (PMID: 12615073) Dowds T.A. … Nunez G. (Biochem. Biophys. Res. Commun. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 49
  4. The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. (PMID: 20061403) Kuenzel S. … Rosenstiel P. (J. Immunol. 2010) 3 4
  5. NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. (PMID: 20434986) Cui J. … Wang R.F. (Cell 2010) 3 4

Products for NLRC5 Gene

  • Addgene plasmids for NLRC5

Sources for NLRC5 Gene

Back to Top

Content