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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NLRC5 Gene

protein-coding GIFtS: 53
GCID: GC16P057023

NLR family, CARD domain containing 5

Explore 4 diseases affiliated with
NLRC5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NLR Family, CARD Domain Containing 5¹ ²		FLJ21709¹
CLR16.1¹ ² ³		NOD-Like Receptor C5²
NOD27¹ ² ³		Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 5²
Caterpiller Protein 16.1² ³		Nucleotide-Binding Oligomerization Domains 27²
Nucleotide-Binding Oligomerization Domain Protein 4² ³		Protein NLRC5²
NOD4² ³		Nucleotide-Binding Oligomerization Domain Protein 27³

External Ids:	HGNC: 29933¹	Entrez Gene: 84166²	Ensembl: ENSG00000140853⁷	OMIM: 613537⁵	UniProtKB: Q86WI3³

Export aliases for NLRC5 gene to outside databases

Previous GC identifers: GC16P055581 GC16P042892

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NLRC5:

This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine

response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I

interferon signaling pathways. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: NLRC5_HUMAN, Q86WI3

Function: Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II

interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense

mechanisms

Gene Wiki entry for NLRC5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NLRC5 gene promoter:
Max1 USF1 STAT1 HTF STAT1beta STAT1alpha USF-1 Pax-4a ATF6 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NLRC5 promoter sequence

Search SABiosciences Chromatin IP Primers for NLRC5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLRC5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q13 HGNC cytogenetic band: 16q13

NLRC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLRC5 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P057023: view genomic region (about GC identifiers)

Start:	57,023,397 bp from pter	End:	57,117,443 bp from pter
Size:	94,047 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NLRC5_HUMAN, Q86WI3 (See protein sequence)

Recommended Name: Protein NLRC5

Size: 1866 amino acids; 204595 Da

Subunit: Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity.

Interacts with DDX58 and IFIH1; blocks the interaction of MAVS to DDX58

Subcellular location: Cytoplasm

Caution: Supposed to contain a CARD domain at the N-terminus (PubMed:20434986). However, this domain is not detected by

Pfam, PROSITE or SMART. Has a weak similarity with a DAPIN domain

Sequence caution: Sequence=BAB55096.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAB55098.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB85008.1;

Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: B5MEF1 C9JMD8 Q6P4A6 Q86VM7 Q8NF42 Q8TEE2 Q8TEJ1 Q969L7

Alternative splicing: 6 isoforms: Q86WI3-1 Q86WI3-2 Q86WI3-3 Q86WI3-4 Q86WI3-5 Q86WI3-6 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for NLRC5: NX_Q86WI3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86WI3

NLRC5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_115582.4

ENSEMBL proteins:

ENSP00000441679 ENSP00000262510 ENSP00000439464 ENSP00000441311 ENSP00000441727

ENSP00000442906 ENSP00000443825 ENSP00000441597 ENSP00000440153 ENSP00000444773

ENSP00000438548 ENSP00000437583 ENSP00000440184 ENSP00000444960 ENSP00000308886

ENSP00000389739

Reactome Protein details: Q86WI3
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	Uscn Proteins for NLRC5

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--

NLRC5 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NLRC5 for domains About GeneDecksing

3 InterPro domains/families:

IPR007111 NACHT_NTPase

IPR001611 Leu-rich_rpt

IPR025875 Leu-rich_rpt_4

Graphical View of Domain Structure for InterPro Entry Q86WI3

ProtoNet protein and cluster: Q86WI3

1 Blocks protein family: IPB000767 Disease resistance protein signature

UniProtKB/Swiss-Prot: NLRC5_HUMAN, Q86WI3

Similarity: Belongs to the NLRP family

Similarity: Contains 26 LRR (leucine-rich) repeats

Similarity: Contains 1 NACHT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NLRC5_HUMAN, Q86WI3

Function: Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II

interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense

mechanisms

Induction: By IFNG/IFN-gamma

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		7 QIAGEN miScript miRNA Assays for microRNAs that regulate NLRC5:
		hsa-miR-1304 hsa-miR-544b hsa-miR-631 hsa-miR-425 hsa-miR-1827 hsa-miR-3652 hsa-miR-3661
		SwitchGear 3'UTR luciferase reporter plasmid: NLRC5 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRC5

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IDA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--

NLRC5 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for NLRC5:

Increased S DNA content

Increased cell size

Animal Models:
Mouse knock-outs for NLRC5: Nlrc5^tm1.1Ggaur Nlrc5^tm1Aki
3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Nlrc5):

hematopoietic system

immune system

no phenotypic analysis

NLRC5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Innate Immune System

0.46

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

1.00

Negative regulators of RIG-I/MDA5 signaling

0.49

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for NLRC5

	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
	Negative regulators of RIG-I/MDA5 signaling
	Immune System
	Innate Immune System

NLRC5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NLRC5

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for NLRC5 (Q86WI3³ ENSP00000262510⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHUK	O15111³, ENSP00000359424⁴	I2D: score=3 STRING: ENSP00000359424
IKBKB	O14920³, ENSP00000339151⁴	I2D: score=2 STRING: ENSP00000339151
DDX58	ENSP00000369213⁴	STRING: ENSP00000369213
IFIH1	ENSP00000263642⁴	STRING: ENSP00000263642
MAVS	ENSP00000401980⁴	STRING: ENSP00000401980

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0032088	negative regulation of NF-kappaB transcription factor activity	IDA	--
GO:0032480	negative regulation of type I interferon production	TAS	--
GO:0043549	regulation of kinase activity	IDA	--
GO:0045087	innate immune response	TAS	--
GO:0045345	positive regulation of MHC class I biosynthetic process	IDA	--

NLRC5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NLRC5
Search CenterWatch for drugs/clinical trials and news about NLRC5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NLRC5 gene:

NM_032206.4

Unigene Cluster for NLRC5:

NLR family, CARD domain containing 5

Hs.528836 [show with all ESTs]

Unigene Representative Sequence: NM_032206

18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):

ENST00000539881(uc010ccq.1) ENST00000262510(uc021tiv.1 uc021tiw.1 uc021tiu.1 uc010ccr.1)

ENST00000543141 ENST00000538273 ENST00000535658 ENST00000544641 ENST00000538059

ENST00000539144 ENST00000538805 ENST00000545081 ENST00000538110 ENST00000536231

ENST00000543030 ENST00000538453(uc002eko.1 uc002ekq.1) ENST00000540182

ENST00000538930 ENST00000538778 ENST00000541020

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		7 QIAGEN miScript miRNA Assays for microRNAs that regulate NLRC5:
		hsa-miR-1304 hsa-miR-544b hsa-miR-631 hsa-miR-425 hsa-miR-1827 hsa-miR-3652 hsa-miR-3661
		SwitchGear 3'UTR luciferase reporter plasmid: NLRC5 3' UTR sequence

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Additional cDNA sequence:

AF389420.1 AK025212.1 AK025362.1 AK027414.1 AK027416.1 AK074133.1 AK074182.1 AK090439.1

AK097030.1 BC040278.1 BC050527.1 BC063566.1 BX640842.1 EF452236.1

18 DOTS entries:

DT.100024310 DT.213053 DT.100795699 DT.97845649 DT.91918928 DT.95136362 DT.100795697 DT.91681344

DT.100795700 DT.40251673 DT.91823833 DT.91893196 DT.92050608 DT.100024309 DT.75121375 DT.95087827

DT.95356925 DT.91942010

24/165 AceView cDNA sequences (see all 165):

BX644817 BX384801 AI439199 CN479308 CR624150 CR609707 AA347231 BI755973

BM993764 CB128075 AW505223 BX384802 AW516362 AL704292 BM469000 BX280877

CA310757 AI439202 BX643552 BC040278 CB242600 BX640842 BF439950 BX280475

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NLRC5 (see all 9) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	^	19	^	20	^	21	^
SP1:																																													-
SP2:															-																						-								-
SP3:																																									-				-
SP4:															-
SP5:

ExUns:	22	^	23	^	24	^	25	^	26a	·	26b	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35	^	36	^	37	^	38	^	39	^	40	^	41	^	42	^	43	^	44	^	45	^	46a	·
SP1:																					-																														-
SP2:
SP3:
SP4:
SP5:

ExUns:	46b	·	46c	^	47	^	48a	·	48b
SP1:	-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for NLRC5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NLRC5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACCCAGTG

About this image
See NLRC5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NLRC5

SOURCE GeneReport for Unigene cluster: Hs.528836

UniProtKB/Swiss-Prot: NLRC5_HUMAN, Q86WI3

Tissue specificity: Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate

SABiosciences Expression via Pathway-Focused PCR Array including NLRC5:

Inflammasomes in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NLRC5 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NLRC5¹	NLR family, CARD domain containing 5	52.12(n) 39.54(a)		100857413 XM_003641889.1 XP_003641937.1
lizard (Anolis carolinensis)	Reptilia	NLRC5⁶	--	34(a)	1 ↔ 1	AAWZ02038269(4539-10438)
zebrafish (Danio rerio)	Actinopterygii	LOC100535184¹	protein NLRC5-like	43.02(n) 30.73(a)		100535184 XM_003200446.1 XP_003200494.1

ENSEMBL Gene Tree for NLRC5 (if available)
TreeFam Gene Tree for NLRC5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NLRC5 gene

NOD2² NOD1² CIITA²

18/56 SIMAP similar genes for NLRC5 using alignment to 12 protein entries: NLRC5_HUMAN (see all proteins) (see all similar genes):

DKFZp686O13216 ARL6IP5 EIF3G NDC80 SNRPF DYNC2LI1

ARIH1 MMADHC TBCB EEF1E1 IDNK ADCK1

pp12301 CDK10 COQ5 NCKAP1L ZNF559 C12orf76

NLRC5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199475984^1,2	C,	untested	57071073(+)	`AGCCAC/TATGCC`	1	--	int¹		0	--	--	--	--
rs199475992^1,2	C,	untested	57080603(+)	`TGAGGC/TGTCAG`	1	--	int¹		0	--	--	--	--
rs199475995^1,2	C,	untested	57085540(+)	`TAAGAC/TGAGAG`	1	--	int¹		0	--	--	--	--
rs199476001^1,2	C,	untested	57092993(+)	`GTCCCC/TGAAAA`	1	--	int¹		0	--	--	--	--
rs199476018^1,2	C,	untested	57113408(+)	`AGATCC/TCCTGA`	1	--	int¹		0	--	--	--	--
rs199476020^1,2	C,	untested	57113552(+)	`TGATTA/GGAAGA`	1	--	int¹		0	--	--	--	--
rs199476023^1,2	C,F	untested	57116443(+)	`TGATGG/ACCCCC`	1	--	ut3¹		1		EU	1317
rs147147126^1,2	C,	other	57059712(+)	`TGAATC/TGGACC`	2	S L	mis¹		0	--	--	--	--
rs149382624^1,2		--	57049007(+)	`GACTAA/GTTTTT`	1	--	us2k¹		0	--	--	--	--
rs185593075^1,2		--	57049076(+)	`CCTCAA/GGTGAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NLRC5 (57023397 - 57117443 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NLRC5
2 Indels: 45441 45442

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NLRC5 for disorders           About GeneDecksing

OMIM gene information: 613537    OMIM disorders: --

4 diseases for NLRC5:    About MalaCards

familial mediterranean fever legionnaires' disease tonsillitis prostatitis

1 disease from the University of Copenhagen DISEASES database for NLRC5:

Legionnaires' disease

Human Genome Epidemiology (HuGE) Navigator: NLRC5 (2 documents)

Export disorders for NLRC5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NLRC5 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with NLRC5)

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Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. (PubMed id 12615073)^{1, 2, 3} Dowds T.A.... Nunez G. (2003)
The nucleotide-binding oligomerization domain-like re ceptor NLRC5 is involved in IFN-dependent antiviral immune responses. (PubMed id 20061403)^{1, 2} Kuenzel S....Rosenstiel P. (2010)
NLRC5 negatively regulates the NF-kappaB and type I i nterferon signaling pathways. (PubMed id 20434986)^{1, 2} Cui J....Wang R.F. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
NLRC5 controls basal MHC class I gene expression in an MHC enhanceosome-dependent manner. (PubMed id 22490867)¹ Neerincx A....Kufer T.A. (2012)
The nucleotide-binding domain of NLRC5 is critical for nuclear import and transactivation activity. (PubMed id 22310711)¹ Meissner T.B....Kobayashi K.S. (2012)
NLRC5 deficiency selectively impairs MHC class I- depe ndent lymphocyte killing by cytotoxic T cells. (PubMed id 22412192)¹ Staehli F....Tschopp J. (2012)
Regulation of immune pathways by the NOD-like receptor NLRC5. (PubMed id 22024701)¹ Lamkanfi M. and Kanneganti T.D. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
NLRC5 cooperates with the RFX transcription factor com plex to induce MHC class I gene expression. (PubMed id 22490869)¹ Meissner T.B....Kobayashi K.S. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84166	HGNC: 29933	AceView: NOD27	Ensembl:ENSG00000140853	euGenes: HUgn84166
ECgene: NLRC5	H-InvDB: NLRC5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NLRC5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NLRC5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NLRC5 gene:
Search GeneIP for patents involving NLRC5

GeneCards and IP:
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NLR family, CARD domain containing 5

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NLR family, CARD domain containing 5

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