NLRC4 Gene
protein-coding GIFtS: 59
GCID: GC02M032449
|
|
NLR family, CARD domain containing 4(Previous names: caspase recruitment domain family, member 12 )
(Previous symbol: CARD12)
| |
Aliases
for NLRC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NLR Family, CARD Domain Containing 41 2 | | Caspase Recruitment Domain-Containing Protein 122 3 | | CARD121 2 3 5 | | Ice Protease-Activating Factor2 3 | | CLAN1 2 3 5 | | CARD, LRR, And NACHT-Containing Protein2 3 | | CLAN11 2 3 | | Ipaf3 | | IPAF2 3 5 | | ICE-Protease Activating Factor2 | | CLANA1 2 | | NLR Family CARD Domain-Containing Protein 42 | | CLANB1 2 | | NOD-Like Receptor C42 | | CLANC1 2 | | Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD DomainContaining 42 | | CLAND1 2 | | Ipaf3 | | CLR2.11 2 | | Clan Protein3 | | Caspase Recruitment Domain Family, Member 121 2 | | |
Export aliases for NLRC4 gene to outside databasesPrevious GC identifers: GC02M032303 GC02M032188 |
Summaries
for NLRC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NLRC4:
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitmentdomains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-bindingdomain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats orleucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.(supplied by OMIM, Mar2008)
UniProtKB/Swiss-Prot: NLRC4_HUMAN, Q9NPP4Function: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungiand responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production andmacrophage pyroptosis
Gene Wiki entry for NLRC4
|
Genomic Views
for NLRC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NLRC4 gene promoter:
MAZR POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) NF-kappaB POU3F2 Tal-1beta HNF-4alpha1 c-Ets-1 CP2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NLRC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLRC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p22-p21 Ensembl cytogenetic band: 2p22.3 HGNC cytogenetic band: 2p22-p21NLRC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M032449: view genomic region
(about GC identifiers)
Start:
|
32,449,518 bp from pter |
End:
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32,490,923 bp from pter |
Size:
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41,406 bases |
Orientation:
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minus strand |
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Proteins
for NLRC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NLRC4_HUMAN, Q9NPP4 (See
protein sequence)Recommended Name: NLR family CARD domain-containing protein 4 Size: 1024 amino acids; 116159 Da
Subunit: Component of the NLRC4 inflammasome (By similarity). Homooligomer. Interacts with ASC, pro-caspase-1, NOD2,BCL10 and NALP1 (NAC) by CARD-CARD interaction
Subcellular location: Cytoplasm. Cytoplasm, cytosol (By similarity). Note=Cytoplasmic filaments
Secondary accessions: A8K9F8 B2RBQ3 B3KTF0 D6W580 Q96J81 Q96J82 Q96J83Alternative splicing: 4 isoforms: Q9NPP4-1 Q9NPP4-2 Q9NPP4-3 Q9NPP4-4 Explore the universe of human proteins at neXtProt for NLRC4: NX_Q9NPP4
Post-translational modifications:
Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation isessential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates Ser-533in vitro (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NPP4
NLRC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001186067.1 NP_001186068.1 NP_067032.3
ENSEMBL proteins: ENSP00000354159 ENSP00000385428 ENSP00000339666 ENSP00000385090 Reactome Protein details: Q9NPP4
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NLRC4 for ontologies About GeneDecksing
NLRC4 Antibody Products:
Assay Products for NLRC4: |
Protein
Domains /
Families
for NLRC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NLRC4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NPP4ProtoNet protein and cluster: Q9NPP4 1 Blocks protein family: IPB001315 CARD interaction domain
UniProtKB/Swiss-Prot: NLRC4_HUMAN, Q9NPP4Similarity: Contains 1 CARD domainSimilarity: Contains 14 LRR (leucine-rich) repeatsSimilarity: Contains 1 NACHT domain |
Function
for NLRC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NLRC4_HUMAN, Q9NPP4Function: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungiand responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production andmacrophage pyroptosis
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLRC4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NLRC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLRC4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRC4 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
NLRC4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NLRC4:
Animal Models:
Mouse knock-outs for NLRC4: Nlrc4tm1Nnz Nlrc4tm1Vmd Nlrc4tm1Gln
2 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Nlrc4):
NLRC4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NLRC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | | | 2 | Immune System | | | 3 | IPAF is activated | | | 4 | Inflammasomes | | | 5 | Direct p53 effectors | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for NLRC4
5/6 
Reactome Pathways for NLRC4 (see all 6)
1 
Kegg Pathway (Kegg details for NLRC4):
NLRC4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NLRC4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/19 Interacting proteins for NLRC4 (Q9NPP41, 2, 3 ENSP000003541594) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002218 | activation of innate immune response |
ISS | -- | | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
IDA | 15030775 | | GO:0006954 | inflammatory response |
ISS | -- | | GO:0016045 | detection of bacterium |
IDA | 15107016 | | GO:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
TAS | -- |
NLRC4 for ontologies About GeneDecksing
|
Drugs & Compounds
for NLRC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NLRC4 for compounds About GeneDecksing
 Browse Tocris compounds for NLRC4
1 Novoseek chemical compound relationship for NLRC4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| peptidoglycan |
64.1 |
2 |
15528373 (1), 15107016 (1) |
Search CenterWatch for drugs/clinical trials and news about NLRC4
|
Transcripts
for NLRC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NLRC4 gene (3 alternative transcripts): NM_001199138.1 NM_001199139.1 NM_021209.4 Unigene Cluster for NLRC4: NLR family, CARD domain containing 4 Hs.574741 [show with all ESTs]Unigene Representative Sequence: AF3760614 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360906(uc021vfq.1) ENST00000402280(uc002roi.3) ENST00000342905
ENST00000404025(uc002roj.2 uc010ezt.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLRC4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLRC4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): NLRC4 (NM_001199139) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NLRC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLRC4 |
Additional cDNA sequence: AF376061.1 AK095467.1 AK292673.1 AK314762.1 AL389934.1 AY027787.1 AY027788.1 AY027789.1 AY027790.1 AY032589.1 AY035391.1 AY358152.1 BC031555.1 4 DOTS entries: DT.100011088 DT.445118 DT.95271230 DT.100722718 18 AceView cDNA sequences: BC031555 NM_021209 AY035391 AI263294 AY358152 AL389934 AK095467 AW337918 AY027788 AW418826 AF376061 BI824482 AY027787 AY032589 BI908869 AY027790 AY027789 BG210375
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for NLRC4 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for NLRC4
|
Expression
for NLRC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NLRC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGTATTTG
About this image
See NLRC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NLRC4
SOURCE GeneReport for Unigene cluster: Hs.574741
UniProtKB/Swiss-Prot: NLRC4_HUMAN, Q9NPP4Tissue specificity: Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 ishighly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta,spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain
SABiosciences Expression via Pathway-Focused PCR Arrays including NLRC4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLRC4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NLRC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLRC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLRC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRC4 |
Orthologs
for NLRC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NLRC4 gene from 2/10 species (see all 10) About this table
ENSEMBL Gene Tree for NLRC4 (if available)
TreeFam Gene Tree for NLRC4 (if available) |
Paralogs
for NLRC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NLRC4 gene
- NAIP2
NLRC4 for paralogs About GeneDecksing
|
Genomic Variants
for NLRC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NLRC4 (32449518 - 32490923 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NLRC4
2 CNVs: 67389 5203 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLRC4 |
|
Disorders
/ Diseases
for NLRC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NLRC4 for disorders About GeneDecksing
OMIM gene information: 606831
OMIM disorders: --
4  diseases for NLRC4: About MalaCardslegionnaires' disease atopic dermatitis dermatitis prostatitis
1 disease from the University of Copenhagen DISEASES database for NLRC4:Legionnaires' disease Human Genome Epidemiology (HuGE) Navigator: NLRC4 (1 document)
Export disorders for NLRC4 gene to outside databases
|
Publications
for NLRC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NLRC4 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with NLRC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. (PubMed id 11374873)1, 2, 3 Geddes B.J.... Bertin J. (2001)
- Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. (PubMed id 15107016)1, 2, 9 Damiano J.S.... Reed J.C. (2004)
- CLAN, a novel human CED-4-like gene. (PubMed id 11472070)1, 2, 9 Damiano J.S.... Reed J.C. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. (PubMed id 11390368)1, 2 Poyet J.-L.... Alnemri E.S. (2001)
- Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis. (PubMed id 16817903)1, 9 Thalappilly S....Swarup G. (2006)
- Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat, and NAIP CIIA HET-E, and TP1-containing protein) in the mammalian innate immune response. (PubMed id 15528373)1, 9 Damiano J.S....Reed J.C. (2004)
- NAIP and Ipaf control Legionella pneumophila replication in human cells. (PubMed id 18453601)1, 9 Vinzing M....Opitz B. (2008)
|
External Searches for NLRC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NLRC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NLRC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NLRC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NLRC4 gene:
Search GeneIP for patents involving NLRC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NLRC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for NLRC4 | | OriGene shRNA RFP for NLRC4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NLRC4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLRC4 | | | OriGene Protein Over-expression Lysate for NLRC4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NLRC4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLRC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLRC4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NLRC4 | | OriGene Custom Protein Services for NLRC4 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NLRC4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLRC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLRC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NLRC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLRC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLRC4 |
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| |  |  |  |  | | | | |
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 | | | NLRC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRC4 |
|  |  |  | | | | ThermoFisher Antibodies for NLRC4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLRC4 |
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