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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NLRC4 Gene

protein-coding   GIFtS: 61
GCID: GC02M032449

NLR Family, CARD Domain Containing 4

(Previous names: caspase recruitment domain family, member 12)
(Previous symbol: CARD12)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NLR Family, CARD Domain Containing 41 2     Nucleotide-Binding Oligomerization Domain1
CARD121 2 3 5     CLANA2
CLAN2 3 5     CLANB2
IPAF2 3 5     CLANC2
Caspase Recruitment Domain Family, Member 121 2     CLAND2
NOD-Like Receptor C41 2     CLR2.12
Caspase Recruitment Domain-Containing Protein 122 3     ICE-Protease Activating Factor2
Ice Protease-Activating Factor2 3     NLR Family CARD Domain-Containing Protein 42
CLAN12 3     Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD
Domain Containing 42
CARD, LRR, And NACHT-Containing Protein2 3     Ipaf3
Leucine Rich Repeat And CARD Domain Containing 41     Clan Protein3

External Ids:    HGNC: 164121   Entrez Gene: 584842   Ensembl: ENSG000000911067   OMIM: 6068315   UniProtKB: Q9NPP43   

Export aliases for NLRC4 gene to outside databases

Previous GC identifers: GC02M032303 GC02M032188


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NLRC4 Gene:
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment
domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM
605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding
domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40
repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.(supplied
by OMIM, Mar 2008)

GeneCards Summary for NLRC4 Gene: 
NLRC4 (NLR family, CARD domain containing 4) is a protein-coding gene. Diseases associated with NLRC4 include legionnaires' disease, and atopic dermatitis, and among its related super-pathways are NOD1/2 Signaling Pathway and Immune System. GO annotations related to this gene include magnesium ion binding and protein homodimerization activity. An important paralog of this gene is NAIP.

UniProtKB/Swiss-Prot: NLRC4_HUMAN, Q9NPP4
Function: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and
fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production
and macrophage pyroptosis

Gene Wiki entry for NLRC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NLRC4 gene promoter:
         MAZR   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   NF-kappaB   POU3F2   Tal-1beta   HNF-4alpha1   c-Ets-1   CP2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NLRC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NLRC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLRC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22-p21   Ensembl cytogenetic band:  2p22.3   HGNC cytogenetic band: 2p22-p21

NLRC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLRC4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M032449:  view genomic region     (about GC identifiers)

Start:
32,449,518 bp from pter      End:
32,490,923 bp from pter
Size:
41,406 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NLRC4_HUMAN, Q9NPP4 (See protein sequence)
Recommended Name: NLR family CARD domain-containing protein 4  
Size: 1024 amino acids; 116159 Da
Subunit: Component of the NLRC4 inflammasome (By similarity). Homooligomer. Interacts with ASC, pro-caspase-1,
NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction. Interacts with EIF2AK2/PKR
Subcellular location: Cytoplasm. Cytoplasm, cytosol (By similarity). Note=Cytoplasmic filaments
Secondary accessions: A8K9F8 B2RBQ3 B3KTF0 D6W580 Q96J81 Q96J82 Q96J83
Alternative splicing: 4 isoforms:  Q9NPP4-1   Q9NPP4-2   Q9NPP4-3   Q9NPP4-4   

Explore the universe of human proteins at neXtProt for NLRC4: NX_Q9NPP4

Explore proteomics data for NLRC4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation is
    essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates
    Ser-533 in vitro (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPP4

  • NLRC4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NLRC4 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001186067.1  NP_001186068.1  NP_067032.3  

    ENSEMBL proteins: 
     ENSP00000354159   ENSP00000385428   ENSP00000339666   ENSP00000385090  
    Reactome Protein details: Q9NPP4
    Human Recombinant Protein Products for NLRC4: 
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    Cloud-Clone Corp. Proteins for NLRC4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS15107016
    GO:0005829cytosol TAS--
    GO:0072557IPAF inflammasome complex ISS--

    NLRC4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NLR: Nucleotide-binding domain and leucine rich repeat containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: IPAF 
    NOD-like receptor family

    4 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR007111 NACHT_NTPase
     IPR027417 P-loop_NTPase
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry Q9NPP4

    ProtoNet protein and cluster: Q9NPP4

    1 Blocks protein domain: IPB001315 CARD interaction domain

    UniProtKB/Swiss-Prot: NLRC4_HUMAN, Q9NPP4
    Similarity: Contains 1 CARD domain
    Similarity: Contains 14 LRR (leucine-rich) repeats
    Similarity: Contains 1 NACHT domain


    NLRC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NLRC4_HUMAN, Q9NPP4
    Function: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and
    fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production
    and macrophage pyroptosis

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding TAS15882992
    GO:0005515protein binding IPI11374873
    GO:0005524ATP binding IDA15882992
    GO:0042802identical protein binding IPI11374873
    GO:0042803protein homodimerization activity IDA15107016
         
    NLRC4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NLRC4:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Nlrc4):
     cellular  immune system 

    NLRC4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NLRC4: Nlrc4tm1Nnz Nlrc4tm1Vmd Nlrc4tm1Gln

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NLRC4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NLRC4

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NLRC4 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.69
    NOD pathway0.33
    NOD-like receptor signaling pathway0.37
    2Immune System
    Immune System0.56
    Innate Immune System0.50
    3Inflammasomes
    Inflammasomes0.71
    4Toll-Like receptor Signaling Pathways
    NOD-like Receptor Signaling Pathways0.59
    5The IPAF inflammasome
    The IPAF inflammasome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NLRC4
        NOD-like Receptor Signaling Pathways


    2 BioSystems Pathways for NLRC4
        NOD pathway
    Direct p53 effectors

    5        Reactome Pathways for NLRC4
        The IPAF inflammasome
    Inflammasomes
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Immune System
    Innate Immune System


    3         Kegg Pathways  (Kegg details for NLRC4):
        NOD-like receptor signaling pathway
    Salmonella infection
    Legionellosis


    NLRC4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NLRC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/20 Interacting proteins for NLRC4 (Q9NPP41, 2, 3 ENSP000003541594) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP1P294661, 2, 3, ENSP000004100764EBI-1222527,EBI-516667 MINT-16578 MINT-16579 I2D: score=5 STRING: ENSP00000410076
    NLRP4Q96MN23, ENSP000003012954I2D: score=3 STRING: ENSP00000301295
    PYCARDQ9ULZ33, ENSP000002474704I2D: score=3 STRING: ENSP00000247470
    CASP8Q147903, ENSP000003512734I2D: score=2 STRING: ENSP00000351273
    PSMC5P621953, ENSP000003105724I2D: score=1 STRING: ENSP00000310572
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002218activation of innate immune response ISS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA15030775
    GO:0006954inflammatory response ISS--
    GO:0016045detection of bacterium IDA15107016
    GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS--

    NLRC4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NLRC4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NLRC4

    1 Novoseek inferred chemical compound relationship for NLRC4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peptidoglycan 64.1 2 15528373 (1), 15107016 (1)

    Search CenterWatch for drugs/clinical trials and news about NLRC4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NLRC4 gene (3 alternative transcripts): 
    NM_001199138.1  NM_001199139.1  NM_021209.4  

    Unigene Cluster for NLRC4:

    NLR family, CARD domain containing 4
    Hs.574741  [show with all ESTs]
    Unigene Representative Sequence: AF376061
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360906(uc021vfq.1) ENST00000402280(uc002roi.3) ENST00000342905
    ENST00000404025(uc002roj.2 uc010ezt.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF376061.1 AK095467.1 AK292673.1 AK314762.1 AL389934.1 AY027787.1 AY027788.1 AY027789.1 
    AY027790.1 AY032589.1 AY035391.1 AY358152.1 BC031555.1 

    4 DOTS entries:

    DT.100011088  DT.445118  DT.95271230  DT.100722718 

    18 AceView cDNA sequences:

    AY035391 BC031555 AW337918 AI263294 NM_021209 AL389934 AY358152 AK095467 
    AW418826 BI824482 AF376061 AY027787 AY027788 AY032589 AY027790 BI908869 
    AY027789 BG210375 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NLRC4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:        -                                                   
    SP2:                                                            
    SP3:        -                 -                                 


    ECgene alternative splicing isoforms for NLRC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NLRC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGTATTTG
    NLRC4 Expression
    About this image


    See NLRC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NLRC4

    SOURCE GeneReport for Unigene cluster: Hs.574741

    UniProtKB/Swiss-Prot: NLRC4_HUMAN, Q9NPP4
    Tissue specificity: Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1
    is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate,
    placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including NLRC4: 
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Antibacterial Response in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLRC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NLRC4 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nlrc41 , 5 NLR family, CARD domain containing 41, 5 79.65(n)1
    75(a)1
      17 (45.64 cM)5
    2689731  NM_001033367.31  NP_001028539.11 
     744262955 
    lizard
    (Anolis carolinensis)
    Reptilia NLRC46
    Uncharacterized protein
    51(a)
    1 ↔ 1
    1(232094976-232111552)


    ENSEMBL Gene Tree for NLRC4 (if available)
    TreeFam Gene Tree for NLRC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NLRC4 gene
    NAIP2  

    NLRC4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/952 SNPs in NLRC4 are shown (see all 952)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1994759581,2
    Cuntested132461253(+) GGCTAC/TGTATT 3 -- int10--------
    rs1994762951,2
    Cuntested132463069(-) TCGATA/TATAAG 3 -- int10--------
    rs1994759551,2
    Cuntested132475403(-) CTCGCA/GGCAGT 6 A syn10--------
    rs1994759531,2
    Cuntested132476005(-) TCATCC/TGAGAA 6 R * stg10--------
    rs1994759501,2
    Cuntested132491018(+) GTAGCA/CTATCT 3 -- us2k10--------
    rs1834063561,2
    C--32449722(+) AATTGC/GTTAAG 6 N K mis10--------
    rs1470267571,2
    C,F--32449741(+) ATACAC/GCCATG 6 A G mis11Minor allele frequency- G:0.00NA 4544
    rs2017373401,2
    C--32449770(+) CTGCTC/TACACG 6 V syn11Minor allele frequency- T:0.00EU 1315
    rs1867595261,2
    C--32449774(+) TCACAC/TGATTT 6 H R mis10--------
    rs617541921,2
    C,F--32449832(+) AAATGC/AACCTG 6 /A /S mis12Minor allele frequency- A:0.01NA EU 5371

    HapMap Linkage Disequilibrium report for NLRC4 (32449518 - 32490923 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NLRC4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719878CNV Deletion23290073
    esv2422335CNV Duplication17116639
    esv21473CNV Loss19812545
    nsv2667CNV Loss18451855
    nsv833670CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606831    OMIM disorders: --

    4 diseases for NLRC4:    About MalaCards
    legionnaires' disease    atopic dermatitis    dermatitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for NLRC4:
    Legionnaires' disease

    NLRC4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NLRC4
    Human Genome Epidemiology (HuGE) Navigator: NLRC4 (1 document)

    Export disorders for NLRC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NLRC4 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with NLRC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. (PubMed id 11374873)1, 2, 3 Geddes B.J.... Bertin J. (2001)
    2. Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. (PubMed id 15107016)1, 2, 9 Damiano J.S.... Reed J.C. (2004)
    3. CLAN, a novel human CED-4-like gene. (PubMed id 11472070)1, 2, 9 Damiano J.S.... Reed J.C. (2001)
    4. Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis. (PubMed id 17620097)1, 4, 9 Macaluso F....Hoffjan S. (2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. (PubMed id 11390368)1, 2 Poyet J.-L.... Alnemri E.S. (2001)
    9. Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis. (PubMed id 16817903)1, 9 Thalappilly S....Swarup G. (2006)
    10. Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat, and NAIP CIIA HET-E, and TP1-containing protein) in the mammalian innate immune response. (PubMed id 15528373)1, 9 Damiano J.S....Reed J.C. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58484 HGNC: 16412 AceView: CARD12 Ensembl:ENSG00000091106 euGenes: HUgn58484
    ECgene: NLRC4 Kegg: 58484 H-InvDB: NLRC4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NLRC4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NLRC4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NLRC4 gene:
    Search GeneIP for patents involving NLRC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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