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Aliases for NLRC3 Gene

Aliases for NLRC3 Gene

  • NLR Family CARD Domain Containing 3 2 3 5
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 3 2 3
  • NACHT, LRR And CARD Domains-Containing Protein 3 3 4
  • Caterpiller Protein 16.2 3 4
  • NOD-Like Receptor C3 2 3
  • CARD15-Like Protein 3 4
  • CLR16.2 3 4
  • NOD3 3 4
  • Nucleotide-Binding Oligomerization Domain Protein 3 4
  • NLR Family CARD Domain-Containing Protein 3 3
  • Protein NLRC3 3

External Ids for NLRC3 Gene

Previous GeneCards Identifiers for NLRC3 Gene

  • GC16M003531
  • GC16M003591
  • GC16M003592

Summaries for NLRC3 Gene

Entrez Gene Summary for NLRC3 Gene

  • This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for NLRC3 Gene

NLRC3 (NLR Family CARD Domain Containing 3) is a Protein Coding gene. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Toll-Like receptor Signaling Pathways. An important paralog of this gene is NOD2.

UniProtKB/Swiss-Prot for NLRC3 Gene

  • Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating Lys-63-linked ubiquitination and leaving unchanged the degradative Lys-48-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106).

Gene Wiki entry for NLRC3 Gene

Additional gene information for NLRC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRC3 Gene

Genomics for NLRC3 Gene

Regulatory Elements for NLRC3 Gene

Enhancers for NLRC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H003644 1.5 Ensembl ENCODE dbSUPER 16.8 -68.1 -68108 3 PKNOX1 FOXA2 SIN3A FOS DEK SP5 MIER3 SMARCA4 HNF4A KDM1A NLRC3 CLUAP1 SRRM2 DNASE1 CREBBP ZNF263 THOC6 ENSG00000261938 ZNF597 ERVK13-1
GH16H003509 0.8 ENCODE 27.2 +68.7 68746 0 TBL1XR1 NFIB BACH1 BATF ZIC2 FOSL1 CTBP1 EED ATF7 ETV6 NLRC3 ZNF200 ZNF205-AS1 CLUAP1 ENSG00000278942
GH16H003499 1.1 ENCODE 19.4 +77.4 77418 2 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 NLRC3 CLUAP1 ZNF200 ZNF174 ZSCAN32 TRAP1 ZNF205-AS1 ENSG00000278942
GH16H003625 1 Ensembl ENCODE 21.3 -48.0 -48036 1 CTCF ZNF654 SOX6 CBFB CEBPB RBBP5 ELF1 CEBPG BATF RAD21 NLRC3 ZNF263 TFAP4 DNASE1 GC16M003627 GC16P003615
GH16H003513 0.6 ENCODE 28.3 +63.9 63879 1 FOXA2 RFX1 REST ZNF2 FOXA1 FOSL1 E2F1 ZNF766 FOS NLRC3 ZNF205-AS1 CLUAP1 ENSG00000278942
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NLRC3 on UCSC Golden Path with GeneCards custom track

Promoters for NLRC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082659 1173 401 POLR2A MAX RUNX3

Genomic Location for NLRC3 Gene

Chromosome:
16
Start:
3,539,033 bp from pter
End:
3,578,373 bp from pter
Size:
39,341 bases
Orientation:
Minus strand

Genomic View for NLRC3 Gene

Genes around NLRC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRC3 Gene

Proteins for NLRC3 Gene

  • Protein details for NLRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTR2-NLRC3_HUMAN
    Recommended name:
    NLR family CARD domain-containing protein 3
    Protein Accession:
    Q7RTR2
    Secondary Accessions:
    • Q5EY36
    • Q8NF48
    • Q8NI01
    • Q8NI02
    • Q8TEL3

    Protein attributes for NLRC3 Gene

    Size:
    1065 amino acids
    Molecular mass:
    114658 Da
    Quaternary structure:
    • Directly interacts (via CARD) with TMEM173/STING; this interaction reduces TMEM173 trafficking to the perinuclear region in response to interferon stimulatory DNA. Also interacts, but to a lesser extent, with TBK1 (PubMed:24560620). Interacts with TRAF6; this interaction results in decreased TRAF6 Lys-63-linked polyubiquitination, but leaves Lys-48-linked chains unchanged, promoting TRAF6 protein degradation (PubMed:22863753). Interacts with PIK3R1/PIK3R2; this interaction disrupts the association between PIK3R1/PIK3R2 and the p110 catalytic subunit PIK3CA/PIK3CB/PIK3CD and reduces PIK3R1/PIK3R2 activation (By similarity). Weakly interacts with PYCARD/ASC. Interacts with CASP1 and CASP5 (PubMed:25277106).
    SequenceCaution:
    • Sequence=BAC03412.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NLRC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NLRC3 Gene

Post-translational modifications for NLRC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NLRC3 Gene

Domains & Families for NLRC3 Gene

Gene Families for NLRC3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NLRC3 Gene

Suggested Antigen Peptide Sequences for NLRC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q7RTR2

UniProtKB/Swiss-Prot:

NLRC3_HUMAN :
  • The leucine-rich repeat domain may reduce the interaction with TMEM173/STING.
  • Belongs to the NLRP family.
Domain:
  • The leucine-rich repeat domain may reduce the interaction with TMEM173/STING.
Family:
  • Belongs to the NLRP family.
genes like me logo Genes that share domains with NLRC3: view

Function for NLRC3 Gene

Molecular function for NLRC3 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating Lys-63-linked ubiquitination and leaving unchanged the degradative Lys-48-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106).
UniProtKB/Swiss-Prot Induction:
In primary T-cells, down-regulated upon T-cell receptor activation (PubMed:15705585). Down-regulated in peritoneal macrophages soon after the beginning of LPS stimulation. Levels start increasing again after 3 days of LPS treatment (PubMed:22863753).

Phenotypes From GWAS Catalog for NLRC3 Gene

Gene Ontology (GO) - Molecular Function for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 24560620
GO:0005524 ATP binding IEA --
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding ISS --
genes like me logo Genes that share ontologies with NLRC3: view
genes like me logo Genes that share phenotypes with NLRC3: view

Animal Models for NLRC3 Gene

MGI Knock Outs for NLRC3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NLRC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NLRC3 Gene

Localization for NLRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRC3 Gene

Cytoplasm.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Microtubule organizing center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 15705585
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol IDA --
GO:0048471 perinuclear region of cytoplasm IDA 24560620
genes like me logo Genes that share ontologies with NLRC3: view

No data available for Subcellular locations from COMPARTMENTS for NLRC3 Gene

Pathways & Interactions for NLRC3 Gene

genes like me logo Genes that share pathways with NLRC3: view

Interacting Proteins for NLRC3 Gene

Gene Ontology (GO) - Biological Process for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007249 I-kappaB kinase/NF-kappaB signaling IDA 15705585
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling ISS --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 15705585
GO:0032687 negative regulation of interferon-alpha production ISS --
GO:0032688 negative regulation of interferon-beta production ISS --
genes like me logo Genes that share ontologies with NLRC3: view

No data available for SIGNOR curated interactions for NLRC3 Gene

Drugs & Compounds for NLRC3 Gene

No Compound Related Data Available

Transcripts for NLRC3 Gene

Unigene Clusters for NLRC3 Gene

NLR family, CARD domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NLRC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NLRC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - -
SP2: - -

Relevant External Links for NLRC3 Gene

GeneLoc Exon Structure for
NLRC3
ECgene alternative splicing isoforms for
NLRC3

Expression for NLRC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NLRC3 Gene

mRNA differential expression in normal tissues according to GTEx for NLRC3 Gene

This gene is overexpressed in Whole Blood (x6.7) and Spleen (x6.4).

Protein differential expression in normal tissues from HIPED for NLRC3 Gene

This gene is overexpressed in Platelet (49.8) and Spleen (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NLRC3 Gene



Protein tissue co-expression partners for NLRC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of NLRC3 Gene:

NLRC3

SOURCE GeneReport for Unigene cluster for NLRC3 Gene:

Hs.592091
genes like me logo Genes that share expression patterns with NLRC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLRC3 Gene

Orthologs for NLRC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRC3 33 34
  • 97.86 (n)
cow
(Bos Taurus)
Mammalia NLRC3 33 34
  • 86.35 (n)
dog
(Canis familiaris)
Mammalia NLRC3 33 34
  • 85.41 (n)
rat
(Rattus norvegicus)
Mammalia Nlrc3 33
  • 81.43 (n)
mouse
(Mus musculus)
Mammalia Nlrc3 33 16 34
  • 81.34 (n)
oppossum
(Monodelphis domestica)
Mammalia NLRC3 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NLRC3 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves NLRC3 33 34
  • 67.36 (n)
lizard
(Anolis carolinensis)
Reptilia NLRC3 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nlrc3 33
  • 57.82 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100334206 33
  • 54.89 (n)
nlrc3 34
  • 44 (a)
OneToOne
Species where no ortholog for NLRC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NLRC3 Gene

ENSEMBL:
Gene Tree for NLRC3 (if available)
TreeFam:
Gene Tree for NLRC3 (if available)

Paralogs for NLRC3 Gene

Paralogs for NLRC3 Gene

(2) SIMAP similar genes for NLRC3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NLRC3: view

Variants for NLRC3 Gene

Sequence variations from dbSNP and Humsavar for NLRC3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs190122309 untested 3,544,380(+) CATTC(C/T)AGCAA intron-variant, nc-transcript-variant
rs199475927 untested 3,578,332(+) TGTGC(C/T)CCATA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs199475928 untested 3,577,780(+) CTCCA(A/G)GCCAC upstream-variant-2KB, utr-variant-5-prime
rs199475929 untested 3,577,680(+) AAATG(C/G)TTGTT upstream-variant-2KB, utr-variant-5-prime
rs199475930 untested 3,577,538(+) TAAGT(G/T)CGGGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NLRC3 Gene

Variant ID Type Subtype PubMed ID
esv2750410 CNV deletion 23290073
nsv1716 CNV insertion 18451855
nsv517451 CNV loss 19592680
nsv571255 CNV gain 21841781
nsv571256 CNV loss 21841781
nsv833128 CNV loss 17160897

Relevant External Links for NLRC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NLRC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NLRC3 Gene

Disorders for NLRC3 Gene

Relevant External Links for NLRC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NLRC3

No disorders were found for NLRC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRC3 Gene

Publications for NLRC3 Gene

  1. Overexpressed NLRC3 acts as an anti-inflammatory cytosolic protein. (PMID: 25277106) Gültekin Y … Özören N (Journal of innate immunity 2015) 2 3 4 60
  2. CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. (PMID: 15705585) Conti BJ … Ting JP (The Journal of biological chemistry 2005) 2 3 4 60
  3. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N … Nuñez G (Nature reviews. Immunology 2003) 2 3 4 60
  4. NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. (PMID: 24560620) Zhang L … Ting JP (Immunity 2014) 3 4 60
  5. The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. (PMID: 22863753) Schneider M … Ting JP (Nature immunology 2012) 3 4 60

Products for NLRC3 Gene

Sources for NLRC3 Gene

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