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Aliases for NLRC3 Gene

Aliases for NLRC3 Gene

  • NLR Family CARD Domain Containing 3 2 3 5
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 3 2 3
  • Caterpiller Protein 16.2 3 4
  • NOD-Like Receptor C3 2 3
  • CARD15-Like Protein 3 4
  • CLR16.2 3 4
  • NOD3 3 4
  • Nucleotide-Binding Oligomerization Domain Protein 3 4
  • NACHT, LRR And CARD Domains-Containing Protein 3 3
  • NLR Family CARD Domain-Containing Protein 3 3
  • Protein NLRC3 3

External Ids for NLRC3 Gene

Previous GeneCards Identifiers for NLRC3 Gene

  • GC16M003531
  • GC16M003591
  • GC16M003592

Summaries for NLRC3 Gene

Entrez Gene Summary for NLRC3 Gene

  • This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for NLRC3 Gene

NLRC3 (NLR Family CARD Domain Containing 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and Cytosolic sensors of pathogen-associated DNA. An important paralog of this gene is NLRC5.

UniProtKB/Swiss-Prot for NLRC3 Gene

  • May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA.

Gene Wiki entry for NLRC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRC3 Gene

Genomics for NLRC3 Gene

Regulatory Elements for NLRC3 Gene

Enhancers for NLRC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G003644 1.6 Ensembl ENCODE dbSUPER 16.8 -68.1 -68108 3.5 PKNOX1 FOXA2 MLX ARNT SIN3A ARID4B DMAP1 YY1 SLC30A9 FOS NLRC3 CLUAP1 DNASE1 TRAP1 PIR33321 PIR47861
GH16G003509 0.8 ENCODE 27.2 +68.7 68746 0.7 MXI1 TBL1XR1 NFIB BACH1 ZIC2 FOSL1 CTBP1 EED ETV6 RELB NLRC3 ZNF200 ZNF205-AS1 CLUAP1 ENSG00000278942
GH16G003499 1.1 ENCODE 19.4 +77.4 77418 2.5 PKNOX1 FOXA2 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF2 NLRC3 CLUAP1 THOC6 ZNF597 ZNF263 LOC105371055 CREBBP ZNF200 ZNF174 ZSCAN32
GH16G003513 0.7 ENCODE 28.3 +63.9 63879 1.3 FOXA2 RFX1 NR2F1 REST ZNF2 FOXA1 FOSL1 E2F1 ZNF766 FOS NLRC3 ZNF205-AS1 CLUAP1 ENSG00000278942
GH16G003625 0.9 Ensembl ENCODE 21.3 -48.0 -48036 1.7 CTCF ZNF654 MTA2 NFIB CBFB CEBPB RBBP5 CEBPG RAD21 SP1 NLRC3 DNASE1 GC16M003627 GC16P003615
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NLRC3 on UCSC Golden Path with GeneCards custom track

Promoters for NLRC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082659 1173 401 POLR2A MAX GATAD2B

Genomic Location for NLRC3 Gene

3,539,033 bp from pter
3,578,373 bp from pter
39,341 bases
Minus strand

Genomic View for NLRC3 Gene

Genes around NLRC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRC3 Gene

Proteins for NLRC3 Gene

  • Protein details for NLRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein NLRC3
    Protein Accession:
    Secondary Accessions:
    • Q5EY36
    • Q8NF48
    • Q8NI01
    • Q8NI02
    • Q8TEL3

    Protein attributes for NLRC3 Gene

    1065 amino acids
    Molecular mass:
    114658 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03412.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NLRC3 Gene


neXtProt entry for NLRC3 Gene

Post-translational modifications for NLRC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NLRC3 Gene

Domains & Families for NLRC3 Gene

Gene Families for NLRC3 Gene


Protein Domains for NLRC3 Gene

Suggested Antigen Peptide Sequences for NLRC3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NLRP family.
  • Belongs to the NLRP family.
genes like me logo Genes that share domains with NLRC3: view

Function for NLRC3 Gene

Molecular function for NLRC3 Gene

UniProtKB/Swiss-Prot Function:
May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA.
UniProtKB/Swiss-Prot Induction:
Down-regulated upon T-cell activation.

Gene Ontology (GO) - Molecular Function for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 24560620
GO:0005524 ATP binding IEA --
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding ISS --
genes like me logo Genes that share ontologies with NLRC3: view
genes like me logo Genes that share phenotypes with NLRC3: view

Animal Models for NLRC3 Gene

MGI Knock Outs for NLRC3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NLRC3 Gene

Localization for NLRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRC3 Gene


Gene Ontology (GO) - Cellular Components for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 15705585
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol IDA --
GO:0048471 perinuclear region of cytoplasm IDA 24560620
genes like me logo Genes that share ontologies with NLRC3: view

No data available for Subcellular locations from COMPARTMENTS for NLRC3 Gene

Pathways & Interactions for NLRC3 Gene

genes like me logo Genes that share pathways with NLRC3: view

Interacting Proteins for NLRC3 Gene

Selected Interacting proteins: Q7RTR2-NLRC3_HUMAN for NLRC3 Gene via IID

Gene Ontology (GO) - Biological Process for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007249 I-kappaB kinase/NF-kappaB signaling IDA 15705585
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling ISS --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 15705585
GO:0032687 negative regulation of interferon-alpha production ISS --
GO:0032688 negative regulation of interferon-beta production ISS --
genes like me logo Genes that share ontologies with NLRC3: view

No data available for SIGNOR curated interactions for NLRC3 Gene

Drugs & Compounds for NLRC3 Gene

No Compound Related Data Available

Transcripts for NLRC3 Gene

Unigene Clusters for NLRC3 Gene

NLR family, CARD domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLRC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - -
SP2: - -

Relevant External Links for NLRC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLRC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NLRC3 Gene

mRNA differential expression in normal tissues according to GTEx for NLRC3 Gene

This gene is overexpressed in Whole Blood (x6.7) and Spleen (x6.4).

Protein differential expression in normal tissues from HIPED for NLRC3 Gene

This gene is overexpressed in Platelet (49.8) and Spleen (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NLRC3 Gene

Protein tissue co-expression partners for NLRC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of NLRC3 Gene:


SOURCE GeneReport for Unigene cluster for NLRC3 Gene:


mRNA Expression by UniProt/SwissProt for NLRC3 Gene:

Tissue specificity: Detected in peripheral blood mononuclear cells.
genes like me logo Genes that share expression patterns with NLRC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLRC3 Gene

Orthologs for NLRC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NLRC3 34 35
  • 97.86 (n)
(Bos Taurus)
Mammalia NLRC3 34 35
  • 86.35 (n)
(Canis familiaris)
Mammalia NLRC3 34 35
  • 85.41 (n)
(Rattus norvegicus)
Mammalia Nlrc3 34
  • 81.43 (n)
(Mus musculus)
Mammalia Nlrc3 34 16 35
  • 81.34 (n)
(Monodelphis domestica)
Mammalia NLRC3 35
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia NLRC3 35
  • 61 (a)
(Gallus gallus)
Aves NLRC3 34 35
  • 67.36 (n)
(Anolis carolinensis)
Reptilia NLRC3 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nlrc3 34
  • 57.82 (n)
(Danio rerio)
Actinopterygii LOC100334206 34
  • 54.89 (n)
nlrc3 35
  • 44 (a)
Species where no ortholog for NLRC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NLRC3 Gene

Gene Tree for NLRC3 (if available)
Gene Tree for NLRC3 (if available)

Paralogs for NLRC3 Gene

Paralogs for NLRC3 Gene

(2) SIMAP similar genes for NLRC3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NLRC3: view

Variants for NLRC3 Gene

Sequence variations from dbSNP and Humsavar for NLRC3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs190122309 untested 3,544,380(+) CATTC(C/T)AGCAA intron-variant, nc-transcript-variant
rs199475927 untested 3,578,332(+) TGTGC(C/T)CCATA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs199475928 untested 3,577,780(+) CTCCA(A/G)GCCAC upstream-variant-2KB, utr-variant-5-prime
rs199475929 untested 3,577,680(+) AAATG(C/G)TTGTT upstream-variant-2KB, utr-variant-5-prime
rs199475930 untested 3,577,538(+) TAAGT(G/T)CGGGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NLRC3 Gene

Variant ID Type Subtype PubMed ID
esv2750410 CNV deletion 23290073
nsv1716 CNV insertion 18451855
nsv517451 CNV loss 19592680
nsv571255 CNV gain 21841781
nsv571256 CNV loss 21841781
nsv833128 CNV loss 17160897

Relevant External Links for NLRC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NLRC3 Gene

Disorders for NLRC3 Gene

Relevant External Links for NLRC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NLRC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRC3 Gene

Publications for NLRC3 Gene

  1. CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. (PMID: 15705585) Conti B.J. … Ting J.P.-Y. (J. Biol. Chem. 2005) 2 3 4 64
  2. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N. … Nunez G. (Nat. Rev. Immunol. 2003) 2 3 4 64
  3. Overexpressed NLRC3 acts as an anti-inflammatory cytosolic protein. (PMID: 25277106) GA1ltekin Y. … A9zAPren N. (J Innate Immun 2015) 2 3 64
  4. Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure. (PMID: 26763980) Coutermarsh-Ott S. … Allen I.C. (J. Gen. Virol. 2016) 3 64
  5. Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components. (PMID: 26378020) Liu R. … Ting J.P. (Oncotarget 2015) 3 64

Products for NLRC3 Gene

Sources for NLRC3 Gene

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