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Aliases for NLRC3 Gene

Aliases for NLRC3 Gene

  • NLR Family, CARD Domain Containing 3 2 3 5
  • Caterpiller Protein 16.2 3 4
  • NOD-Like Receptor C3 2 3
  • CARD15-Like Protein 3 4
  • CLR16.2 3 4
  • NOD3 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 3 3
  • Nucleotide-Binding Oligomerization Domain Protein 3 4
  • Leucine Rich Repeat And CARD Domain Containing 3 2
  • Nucleotide-Binding Oligomerization Domain 2

External Ids for NLRC3 Gene

Previous GeneCards Identifiers for NLRC3 Gene

  • GC16M003531
  • GC16M003591
  • GC16M003592

Summaries for NLRC3 Gene

Entrez Gene Summary for NLRC3 Gene

  • This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for NLRC3 Gene

NLRC3 (NLR Family, CARD Domain Containing 3) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways. An important paralog of this gene is NLRP7.

UniProtKB/Swiss-Prot for NLRC3 Gene

  • May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA.

Gene Wiki entry for NLRC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRC3 Gene

Genomics for NLRC3 Gene

Regulatory Elements for NLRC3 Gene

Enhancers for NLRC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NLRC3 on UCSC Golden Path with GeneCards custom track

Promoters for NLRC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NLRC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NLRC3 Gene

3,539,033 bp from pter
3,578,373 bp from pter
39,341 bases
Minus strand

Genomic View for NLRC3 Gene

Genes around NLRC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRC3 Gene

Proteins for NLRC3 Gene

  • Protein details for NLRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein NLRC3
    Protein Accession:
    Secondary Accessions:
    • Q5EY36
    • Q8NF48
    • Q8NI01
    • Q8NI02
    • Q8TEL3

    Protein attributes for NLRC3 Gene

    1065 amino acids
    Molecular mass:
    114658 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03412.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NLRC3 Gene


neXtProt entry for NLRC3 Gene

Proteomics data for NLRC3 Gene at MOPED

Post-translational modifications for NLRC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRC3 Gene

Antibody Products

No data available for DME Specific Peptides for NLRC3 Gene

Domains & Families for NLRC3 Gene

Gene Families for NLRC3 Gene


Protein Domains for NLRC3 Gene

Suggested Antigen Peptide Sequences for NLRC3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 NACHT domain.
  • Belongs to the NLRP family.
  • Contains 16 LRR (leucine-rich) repeats.
  • Contains 1 NACHT domain.
  • Belongs to the NLRP family.
  • Contains 16 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRC3: view

Function for NLRC3 Gene

Molecular function for NLRC3 Gene

UniProtKB/Swiss-Prot Function:
May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA.
UniProtKB/Swiss-Prot Induction:
Down-regulated upon T-cell activation.

Gene Ontology (GO) - Molecular Function for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NLRC3: view
genes like me logo Genes that share phenotypes with NLRC3: view

Animal Models for NLRC3 Gene

MGI Knock Outs for NLRC3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NLRC3 Gene

Localization for NLRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRC3 Gene


No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NLRC3 Gene

Pathways & Interactions for NLRC3 Gene

genes like me logo Genes that share pathways with NLRC3: view

Pathways by source for NLRC3 Gene

1 R&D Systems pathway for NLRC3 Gene

Interacting Proteins for NLRC3 Gene

Selected Interacting proteins: Q7RTR2-NLRC3_HUMAN for NLRC3 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007249 I-kappaB kinase/NF-kappaB signaling IDA 15705585
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 15705585
GO:0032720 negative regulation of tumor necrosis factor production IMP 22863753
genes like me logo Genes that share ontologies with NLRC3: view

No data available for SIGNOR curated interactions for NLRC3 Gene

Drugs & Compounds for NLRC3 Gene

No Compound Related Data Available

Transcripts for NLRC3 Gene

Unigene Clusters for NLRC3 Gene

NLR family, CARD domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NLRC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - -
SP2: - -

Relevant External Links for NLRC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLRC3 Gene

mRNA expression in normal human tissues for NLRC3 Gene

mRNA differential expression in normal tissues according to GTEx for NLRC3 Gene

This gene is overexpressed in Whole Blood (x6.7) and Spleen (x6.4).

Protein differential expression in normal tissues from HIPED for NLRC3 Gene

This gene is overexpressed in Platelet (49.8) and Spleen (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NLRC3 Gene

SOURCE GeneReport for Unigene cluster for NLRC3 Gene Hs.592091

mRNA Expression by UniProt/SwissProt for NLRC3 Gene

Tissue specificity: Detected in peripheral blood mononuclear cells.
genes like me logo Genes that share expression patterns with NLRC3: view

Protein tissue co-expression partners for NLRC3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NLRC3 Gene

Orthologs for NLRC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NLRC3 35
  • 86.35 (n)
  • 85.26 (a)
NLRC3 36
  • 85 (a)
(Canis familiaris)
Mammalia NLRC3 35
  • 85.41 (n)
  • 84.88 (a)
NLRC3 36
  • 85 (a)
(Mus musculus)
Mammalia Nlrc3 35
  • 81.34 (n)
  • 80.3 (a)
Nlrc3 16
Nlrc3 36
  • 78 (a)
(Pan troglodytes)
Mammalia NLRC3 35
  • 97.86 (n)
  • 97.63 (a)
NLRC3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nlrc3 35
  • 81.43 (n)
  • 80.49 (a)
(Monodelphis domestica)
Mammalia NLRC3 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia NLRC3 36
  • 61 (a)
(Gallus gallus)
Aves NLRC3 35
  • 67.36 (n)
  • 61.32 (a)
NLRC3 36
  • 60 (a)
(Anolis carolinensis)
Reptilia NLRC3 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nlrc3 35
  • 57.82 (n)
  • 52.86 (a)
(Danio rerio)
Actinopterygii LOC100334206 35
  • 54.89 (n)
  • 48.28 (a)
nlrc3 36
  • 44 (a)
Species with no ortholog for NLRC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NLRC3 Gene

Gene Tree for NLRC3 (if available)
Gene Tree for NLRC3 (if available)

Paralogs for NLRC3 Gene

(2) SIMAP similar genes for NLRC3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NLRC3: view

Variants for NLRC3 Gene

Sequence variations from dbSNP and Humsavar for NLRC3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_034606 -
rs2860 -- 3,539,938(-) ctgca(A/G)aataa nc-transcript-variant, utr-variant-3-prime
rs1124285 -- 3,539,846(-) tataa(C/T)ttaat nc-transcript-variant, utr-variant-3-prime
rs1134603 -- 3,540,165(+) ATTAG(G/T)ATATC nc-transcript-variant, utr-variant-3-prime
rs28447368 -- 3,580,308(+) TCCTA(A/C)CCCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NLRC3 Gene

Variant ID Type Subtype PubMed ID
nsv905213 CNV Loss 21882294
nsv1716 CNV Insertion 18451855
nsv833128 CNV Loss 17160897
nsv905216 CNV Loss 21882294
esv2750410 CNV Deletion 23290073
nsv517451 CNV Loss 19592680
nsv905217 CNV Loss 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for NLRC3 Gene

Disorders for NLRC3 Gene

Relevant External Links for NLRC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NLRC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRC3 Gene

Publications for NLRC3 Gene

  1. CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. (PMID: 15705585) Conti B.J. … Ting J.P.-Y. (J. Biol. Chem. 2005) 2 3 4 67
  2. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N. … Nunez G. (Nat. Rev. Immunol. 2003) 2 3
  3. Overexpressed NLRC3 acts as an anti-inflammatory cytosolic protein. (PMID: 25277106) GA1ltekin Y. … A9zAPren N. (J Innate Immun 2015) 3
  4. NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING. (PMID: 24560620) Zhang L. … Ting J.P. (Immunity 2014) 3
  5. Unsolved Mysteries in NLR Biology. (PMID: 24062750) Lupfer C. … Kanneganti T.D. (Front Immunol 2013) 3

Products for NLRC3 Gene

Sources for NLRC3 Gene