Aliases for NLRC3 Gene
External Ids for NLRC3 Gene
Previous GeneCards Identifiers for NLRC3 Gene
This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
GeneCards Summary for NLRC3 Gene
NLRC3 (NLR Family CARD Domain Containing 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and Cytosolic sensors of pathogen-associated DNA. An important paralog of this gene is NLRC5.
UniProtKB/Swiss-Prot for NLRC3 Gene
May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA.