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Aliases for NLRC3 Gene

Aliases for NLRC3 Gene

  • NLR Family, CARD Domain Containing 3 2 3
  • Caterpiller Protein 16.2 3 4
  • NOD-Like Receptor C3 2 3
  • CARD15-Like Protein 3 4
  • CLR16.2 3 4
  • NOD3 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 3 3
  • Nucleotide-Binding Oligomerization Domain Protein 3 4
  • Leucine Rich Repeat And CARD Domain Containing 3 2
  • Nucleotide-Binding Oligomerization Domain 2
  • Protein NLRC3 3

External Ids for NLRC3 Gene

Previous GeneCards Identifiers for NLRC3 Gene

  • GC16M003531
  • GC16M003591
  • GC16M003592

Summaries for NLRC3 Gene

Entrez Gene Summary for NLRC3 Gene

  • This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for NLRC3 Gene

NLRC3 (NLR Family, CARD Domain Containing 3) is a Protein Coding gene. Among its related pathways are NOD-like Receptor Signaling Pathways. An important paralog of this gene is NLRP7.

UniProtKB/Swiss-Prot for NLRC3 Gene

  • May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA.

Gene Wiki entry for NLRC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRC3 Gene

Genomics for NLRC3 Gene

Regulatory Elements for NLRC3 Gene

Genomic Location for NLRC3 Gene

Start:
3,539,033 bp from pter
End:
3,577,400 bp from pter
Size:
38,368 bases
Orientation:
Minus strand

Genomic View for NLRC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRC3 Gene

Proteins for NLRC3 Gene

  • Protein details for NLRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTR2-NLRC3_HUMAN
    Recommended name:
    Protein NLRC3
    Protein Accession:
    Q7RTR2
    Secondary Accessions:
    • Q5EY36
    • Q8NF48
    • Q8NI01
    • Q8NI02
    • Q8TEL3

    Protein attributes for NLRC3 Gene

    Size:
    1065 amino acids
    Molecular mass:
    114658 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03412.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NLRC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NLRC3 Gene

Proteomics data for NLRC3 Gene at MOPED

Post-translational modifications for NLRC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRC3 Gene

No data available for DME Specific Peptides for NLRC3 Gene

Domains for NLRC3 Gene

Gene Families for NLRC3 Gene

HGNC:
  • NLR :Nucleotide-binding domain and leucine rich repeat containing
IUPHAR :

Protein Domains for NLRC3 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NLRC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q7RTR2

UniProtKB/Swiss-Prot:

NLRC3_HUMAN :
  • Q7RTR2
Domain:
  • Contains 1 NACHT domain.
Family:
  • Belongs to the NLRP family.
Similarity:
  • Contains 16 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRC3: view

Function for NLRC3 Gene

Molecular function for NLRC3 Gene

UniProtKB/Swiss-Prot Function: May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA.
UniProtKB/Swiss-Prot Induction: Down-regulated upon T-cell activation.

Gene Ontology (GO) - Molecular Function for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRC3: view
genes like me logo Genes that share phenotypes with NLRC3: view

Animal Models for NLRC3 Gene

MGI Knock Outs for NLRC3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NLRC3 Gene

Localization for NLRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRC3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLRC3 Gene COMPARTMENTS Subcellular localization image for NLRC3 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15705585
genes like me logo Genes that share ontologies with NLRC3: view

Pathways for NLRC3 Gene

genes like me logo Genes that share pathways with NLRC3: view

Pathways by source for NLRC3 Gene

1 R&D Systems pathway for NLRC3 Gene

Interacting Proteins for NLRC3 Gene

Selected Interacting proteins: Q7RTR2-NLRC3_HUMAN for NLRC3 Gene via I2D

Symbol External ID(s) Details
ELF3

Gene Ontology (GO) - Biological Process for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007249 I-kappaB kinase/NF-kappaB signaling IDA 15705585
GO:0031396 regulation of protein ubiquitination IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 15705585
GO:0032496 response to lipopolysaccharide IEA --
GO:0032715 negative regulation of interleukin-6 production IMP 22863753
genes like me logo Genes that share ontologies with NLRC3: view

Transcripts for NLRC3 Gene

Unigene Clusters for NLRC3 Gene

NLR family, CARD domain containing 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NLRC3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NLRC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLRC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - -
SP2: - -

Relevant External Links for NLRC3 Gene

GeneLoc Exon Structure for
NLRC3
ECgene alternative splicing isoforms for
NLRC3

Expression for NLRC3 Gene

mRNA expression in normal human tissues for NLRC3 Gene

mRNA differential expression in normal tissues according to GTEx for NLRC3 Gene

This gene is overexpressed in Whole Blood (6.7) and Spleen (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NLRC3 Gene

SOURCE GeneReport for Unigene cluster for NLRC3 Gene Hs.592091

mRNA Expression by UniProt/SwissProt for NLRC3 Gene

Q7RTR2-NLRC3_HUMAN
Tissue specificity: Detected in peripheral blood mononuclear cells.
genes like me logo Genes that share expressions with NLRC3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NLRC3 Gene

Orthologs for NLRC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRC3 35
  • 97.86 (n)
  • 97.63 (a)
NLRC3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NLRC3 35
  • 86.35 (n)
  • 85.26 (a)
NLRC3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NLRC3 35
  • 85.41 (n)
  • 84.88 (a)
NLRC3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nlrc3 35
  • 81.34 (n)
  • 80.3 (a)
Nlrc3 16
Nlrc3 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NLRC3 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NLRC3 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nlrc3 35
  • 81.43 (n)
  • 80.49 (a)
chicken
(Gallus gallus)
Aves NLRC3 35
  • 67.36 (n)
  • 61.32 (a)
NLRC3 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NLRC3 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nlrc3 35
  • 57.82 (n)
  • 52.86 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100334206 35
  • 54.89 (n)
  • 48.28 (a)
nlrc3 36
  • 44 (a)
OneToOne
Species with no ortholog for NLRC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NLRC3 Gene

ENSEMBL:
Gene Tree for NLRC3 (if available)
TreeFam:
Gene Tree for NLRC3 (if available)

Paralogs for NLRC3 Gene

Selected SIMAP similar genes for NLRC3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NLRC3: view

Variants for NLRC3 Gene

Sequence variations from dbSNP and Humsavar for NLRC3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2860 -- 3,539,938(-) ctgca(A/G)aataa utr-variant-3-prime, nc-transcript-variant
rs758747 -- 3,577,357(+) AGCCC(C/T)GACCT utr-variant-5-prime, nc-transcript-variant
rs1124285 -- 3,539,846(-) tataa(C/T)ttaat utr-variant-3-prime, nc-transcript-variant
rs1134603 -- 3,540,165(+) ATTAG(G/T)ATATC utr-variant-3-prime, nc-transcript-variant
rs1296734 -- 3,575,569(-) CCTGG(C/G)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLRC3 Gene

Variant ID Type Subtype PubMed ID
nsv905213 CNV Loss 21882294
nsv1716 CNV Insertion 18451855
nsv833128 CNV Loss 17160897
nsv905216 CNV Loss 21882294
esv2750410 CNV Deletion 23290073
nsv517451 CNV Loss 19592680
nsv905217 CNV Loss 21882294

Relevant External Links for NLRC3 Gene

HapMap Linkage Disequilibrium report
NLRC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRC3 Gene

Disorders for NLRC3 Gene

No disorders were found for NLRC3 Gene.

No data available for UniProtKB/Swiss-Prot for NLRC3 Gene

Publications for NLRC3 Gene

  1. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N. … Nunez G. (Nat. Rev. Immunol. 2003) 2 3 4
  2. CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. (PMID: 15705585) Conti B.J. … Ting J.P.-Y. (J. Biol. Chem. 2005) 2 3 4
  3. Downregulation of immune signaling genes in patients with large surface burn injury. (PMID: 17925653) Moore C.B. … Cairns B.A. (J Burn Care Res 2007) 3
  4. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for NLRC3 Gene

Sources for NLRC3 Gene

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