Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NLN Gene

protein-coding   GIFtS: 57
GCID: GC05P065018

neurolysin (metallopeptidase M3 family)

(Previous name: angiotensin binding protein )
(Previous symbol: AGTBP)
 Explore 4 diseases affiliated with
NLN via our new
 Human Malady Compendium 
Biological research products
for NLN
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Neurolysin (Metallopeptidase M3 Family)1 2     MEP2 3
AGTBP1 2 3 5     EC 3.4.24.163 8
KIAA12261 3 5     EP24.162
Angiotensin Binding Protein1 2     MOP2
Angiotensin-Binding Protein2 3     Endopeptidase 24.162
Microsomal Endopeptidase2 3     Neurolysin, Mitochondrial2
Mitochondrial Oligopeptidase M2 3     EC 3.4.248
Neurotensin Endopeptidase2 3     

External Ids:    HGNC: 160581   Entrez Gene: 574862   Ensembl: ENSG000001232137   OMIM: 6115305   UniProtKB: Q9BYT83   

Export aliases for NLN gene to outside databases

Previous GC identifers: GC05P065169 GC05P066556 GC05P064988 GC05P065033 GC05P065053 GC05P061976


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NLN:
This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond,
leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the
termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.(provided
by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: NEUL_HUMAN, Q9BYT8
Function: Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity)

Gene Wiki entry for NLN


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NLN gene promoter:
         GR   STAT1   Lmo2   STAT1beta   STAT1alpha   E47   Max   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLN promoter sequence
   Search SABiosciences Chromatin IP Primers for NLN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12.3

NLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLN gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P065018:  view genomic region     (about GC identifiers)

Start:
65,018,023 bp from pter      End:
65,167,553 bp from pter
Size:
149,531 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NEUL_HUMAN, Q9BYT8 (See protein sequence)
Recommended Name: Neurolysin, mitochondrial precursor  
Size: 704 amino acids; 80652 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Mitochondrion intermembrane space (By similarity). Cytoplasm (By similarity)
Secondary accessions: Q9ULJ4

Explore the universe of human proteins at neXtProt for NLN: NX_Q9BYT8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BYT8

  • 4/21 DME Specific Peptides for NLN (Q9BYT8) (see all 21)
     LQETCDL  ASTEADK  RNGLHLP  THADFVLE 

    NLN Protein expression data from MOPED and PaxDb:    About this image 
    NLN Protein Expression
    REFSEQ proteins: NP_065777.1  
    ENSEMBL proteins: 
     ENSP00000370372   ENSP00000423214   ENSP00000422822   ENSP00000427417   ENSP00000426959  

    Human Recombinant Protein Products for NLN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NLN (Neurolysin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NLN
    OriGene Protein Over-expression Lysate: NLN
    OriGene Custom Protein Services for NLN 
    GenScript Custom Purified and Recombinant Proteins Services for NLN
    Novus Biologicals NLN Protein
    Novus Biologicals NLN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NLN

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005758mitochondrial intermembrane space IEA--

    NLN for ontologies           About GeneDecksing



    NLN Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NLN (Neurolysin)
    OriGene Antibodies (see all 8): NLN
    OriGene Custom Antibody Services for NLN 
    GenScript Custom Superior Antibodies Services for NLN
    Novus Biologicals NLN Antibodies
    Abcam antibodies for NLN 
    Uscn Antibodies for NLN
    Search ThermoFisher Antibodies for NLN

    Assay Products for NLN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NLN
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NLN


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NLN for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR024079 MetalloPept_cat_dom
     IPR024077 Neurolysin/TOP_dom2
     IPR001567 Pept_M3A_M3B
     IPR024080 Neurolysin/TOP_N

    Graphical View of Domain Structure for InterPro Entry Q9BYT8

    ProtoNet protein and cluster: Q9BYT8

    1 Blocks protein family: IPB001567 Peptidase M3

    UniProtKB/Swiss-Prot: NEUL_HUMAN, Q9BYT8
    Similarity: Belongs to the peptidase M3 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEUL_HUMAN, Q9BYT8
    Function: Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity)
    Catalytic activity: Preferential cleavage in neurotensin: 10-Pro- -Tyr-11

         Enzyme Numbers (IUBMB): EC 3.4.24.161 2 EC 3.4.242

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0046872metal ion binding IEA--
         
    NLN for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NLN:
     Decreased viability  Increased G2M DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nln):
     no phenotypic analysis 

    NLN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NLN 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: NLN
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NLN
    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate NLN (see all 88):
    hsa-miR-579 hsa-miR-605 hsa-miR-128 hsa-miR-632 hsa-miR-374a hsa-miR-3909 hsa-miR-1231 hsa-miR-27a
    SwitchGear 3'UTR luciferase reporter plasmidNLN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NLN (see all 7)
    OriGene shRNA RFP: NLN
    OriGene siRNA: NLN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NLN
    Sirion Biotech Custom design and validation of potent shRNA sequences against NLN 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NLN
    Sirion Biotech Customized adenovirus for overexpression of NLN 
    Sirion Biotech Customized adenovirus for potent knockdown of NLN

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLN (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLN (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for NLN
    Sino Biological Human cDNA Clone for NLN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLN 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NLN
    Search LifeMap BioReagents cell lines for NLN
    Sirion Biotech Customized stable knockdown cell line services for NLN 
    Sirion Biotech Customized inducible knockdown cell line services for NLN
    Sirion Biotech Customized stable overexpressing cell line services for NLN
    Sirion Biotech Customized inducible overexpressing cell line services for NLN

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Renin-angiotensin system
    Renin-angiotensin system1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for NLN):
        Renin-angiotensin system


    NLN for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NLN

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for NLN (Q9BYT83 ENSP000003703724) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTSP309903, ENSP000002560104I2D: score=1 STRING: ENSP00000256010
    CLN3Q132863I2D: score=1 
    CBX1ENSP000002256034STRING: ENSP00000225603
    UBCENSP000003448184STRING: ENSP00000344818
    ZMPSTE24ENSP000003618454STRING: ENSP00000361845
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    NLN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NLN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NLN

    7 HMDB Compounds for NLN    About this table
    CompoundSynonyms CAS #PubMed Ids
    BradykininCallidin I (see all 5)58-82-2--
    Dynorphin ATyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln;dynorphin A 1-17 80448-90-4--
    Dynorphin A 1-8Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile;dynorphin A (1-8);dynorphin A fragment 1-8 75790-53-3--
    Dynorphin A 9-17dynorphin A (9-17);Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln ----
    Neurotensin 1-10pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro;neurotensin (1-10);neurotensin fragment 1-10 ----
    Neurotensin 11-13Tyr-Ile-Leu;neurotensin (11-13);neurotensin fragment 11-13 ----
    ZincZinc (see all 2)7440-66-6--
    5 Novoseek chemical compound relationships for NLN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thimet 96.3 30 11355859 (2), 12706825 (2), 17313369 (2), 10235115 (2) (see all 17)
    n-(2,4-dinitrophenyl)ethylenediamine 93 2 12199711 (1), 17313369 (1)
    anthranilate 61.2 1 12199711 (1)
    phosphorus 19.3 3 17284829 (2), 17277461 (1)
    cysteine 5.4 1 12968080 (1)

    Search CenterWatch for drugs/clinical trials and news about NLN / NEUL 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NLN gene: 
    NM_020726.4  

    Unigene Cluster for NLN:

    Neurolysin (metallopeptidase M3 family)
    Hs.247460  [show with all ESTs]
    Unigene Representative Sequence: NM_020726
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380985(uc003juf.3) ENST00000502464(uc010iww.3) ENST00000514991
    ENST00000506539(uc003jue.3) ENST00000506799 ENST00000506677 ENST00000511299
    ENST00000509935 ENST00000507201 ENST00000515595

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: NLN
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NLN
    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate NLN (see all 88):
    hsa-miR-579 hsa-miR-605 hsa-miR-128 hsa-miR-632 hsa-miR-374a hsa-miR-3909 hsa-miR-1231 hsa-miR-27a
    SwitchGear 3'UTR luciferase reporter plasmidNLN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NLN (see all 7)
    OriGene shRNA RFP: NLN
    OriGene siRNA: NLN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NLN
    Sirion Biotech Custom design and validation of potent shRNA sequences against NLN 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLN (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLN (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for NLN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLN 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLN
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NLN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLN

    Additional cDNA sequence: 

    AB033052.2 AJ300837.1 AK027602.1 AK096416.1 AK292803.1 AL834241.1 BC001644.2 BC004985.1 

    9 DOTS entries:

    DT.120812726  DT.413015  DT.312876  DT.100795391  DT.120812776  DT.120812703  DT.120812774  DT.120812688 
    DT.120812750 

    24/188 AceView cDNA sequences (see all 188):

    BM678776 BM720496 BE302168 BE207850 AI669585 AI300009 BC004985 AA621092 
    BC001644 BP377461 BM472616 AI687231 C00452 AI457909 BU688683 AA557562 
    AB033052 CR613085 AI952756 CB143952 BM907261 AW594243 Z32885 BP341839 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NLN (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:        -                             -                       -                       -     -                       -                     
    SP2:        -                             -                       -                                                                           
    SP3:                                                              -                 -     -     -                       -                     
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for NLN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NLN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    NLN Expression
    About this image
    See NLN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NLN

    SOURCE GeneReport for Unigene cluster: Hs.247460
        SABiosciences Custom PCR Arrays for NLN

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLN
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NLN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for NLN gene from 10/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nln1 , 5 neurolysin (metallopeptidase M3 family)1, 5 87.15(n)1
    90.33(a)1
      13 (56.16 cM)5
    758051  NM_029447.21  NP_083723.11 
     1040234395 
    chicken
    (Gallus gallus)
    Aves NLN1 neurolysin (metallopeptidase M3 family) 75.54(n)
    77.99(a)
      427167  XM_424755.2  XP_424755.2 
    lizard
    (Anolis carolinensis)
    Reptilia NLN6
    --
    74(a)
    1 ↔ 1
    2(10793232-10817468)
    zebrafish
    (Danio rerio)
    Actinopterygii thop16
    thimet oligopeptidase 1
    57(a)
    1 ↔ 1
    10(15437164-15476159)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG117713 oligopeptidase A 24(a)   96B10   --
    worm
    (Caenorhabditis elegans)
    Secernentea ZK550.36
    --
    15(a)
    possible ortholog
    IV(17250094-17254927)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRD11 Prd1p 46.82(n)
    36.82(a)
      850301   NP_009874.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G676906
    AT5G105406
    (see all 3)
    oligopeptidase A
    (see all 3)
    31(a)
    26(a)
    (see all 3)
    many → 1
    possible ortholog
    (see all 3)
    1(25369086-25373730)
    5(3328065-3334971)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    oligopeptidase, putative, expressed
    31(a)
    23(a)
    many → 1
    possible ortholog
    1(39288254-39295603)
    2(35676940-35682638)
    E. coli
    (Escherichia coli)
    Gamma proteobacteria prlC6
    dcp6
    dipeptidyl carboxypeptidase II
    28(a)
    22(a)
    possible ortholog
    possible ortholog
    Chromosome(3641163-3643205)
    Chromosome(1623359-1625404)


    ENSEMBL Gene Tree for NLN (if available)
    TreeFam Gene Tree for NLN (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NLN gene
    THOP12  
    18/72 SIMAP similar genes for NLN using alignment to 5 protein entries:     NEUL_HUMAN (see all proteins) (see all similar genes):
    DKFZp564F123    NDUFS3    RRM2B    UBE2B    MRPL45    TBCB
    TMX3    TUBA1C    RHBG    SLC24A1    HEXDC    NDC80
    ASCC1    FANCA    SH2B3    UBE2V2    ACTR10    CALCOCO2

    NLN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1627 NCBI SNPs in NLN are shown (see all 1627    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs109400471,2
    C,A,H--65020088(+) CCATTA/GCTTCC 1 -- int14Minor allele frequency- G:0.29NA WA EA 360
    rs801242681,2
    C--65020175(+) GACAAC/G/TATTTG 1 -- int12CSA WA 120
    rs787277681,2
    C--65020176(+) ACAATA/GTTTGT 1 -- int10--------
    rs747406311,2
    C--65020178(+) AATATC/TTGTCC 1 -- int10--------
    rs1413096701,2
    --65020220(+) TTAAGA/GTTTAT 1 -- int10--------
    rs1147149211,2
    F--65020254(+) TTTCCT/CTTTTA 1 -- int11Minor allele frequency- C:0.03NA 120
    rs1140662301,2
    --65020370(+) TATGAT/CCATTA 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1858944221,2
    --65020384(+) TGCACA/GTGTCT 1 -- int10--------
    rs1902211801,2
    --65020455(+) GAGTCA/GTAGGA 1 -- int10--------
    rs1450842871,2
    --65020468(+) GTACTA/GTGTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for NLN (65018023 - 65167553 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for NLN
         3 CNVs: 39422 39421 64223

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLN
    DNA2.0 Custom Variant and Variant Library Synthesis for NLN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NLN for disorders           About GeneDecksing

    OMIM gene information: 611530    OMIM disorders: --

    4 diseases for NLN:    About MalaCards
    cervical adenocarcinoma    cervicitis    adenocarcinoma    schizophrenia

    Human Genome Epidemiology (HuGE) Navigator: NLN (2 documents)

    Export disorders for NLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NLN gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with NLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    3. Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. (PubMed id 17251185)1, 9 Lim E.J....Rodgers D.W. (2007)
    4. Confocal microscopy reveals thimet oligopeptidase (EC 3.4.24.15) and neurolysin (EC 3.4.24.16) in the classical secretory pathway. (PubMed id 10235115)1, 9 Garrido P.A....Beaudet A. (1999)
    5. Endopeptidases 3.4.24.15 and 24.16 in endothelial cells: potential role in vasoactive peptide metabolism. (PubMed id 12609826)1, 9 Norman M.U....Lew R.A. (2003)
    6. Neuropeptide specificity and inhibition of recombinant isoforms of the endopeptidase 3.4.24.16 family: comparison with the related recombinant endopeptidase 3.4.24.15. (PubMed id 9735321)1, 9 Rioli V....Ferro E.S. (1998)
    7. Stably transfected human cells overexpressing rat brain endopeptidase 3.4.24.16: biochemical characterization of the activity and expression of soluble and membrane-associated counterparts. (PubMed id 9003076)1, 9 Vincent B....Checler F. (1997)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57486 HGNC: 16058 AceView: NLN Ensembl:ENSG00000123213 euGenes: HUgn57486
    ECgene: NLN Kegg: 57486 H-InvDB: NLN

    (According to HUGE)
    About This Section
    HUGE: KIAA1226

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NLN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NLN gene:
    Search GeneIP for patents involving NLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NLN (Neurolysin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for NLN (Neurolysin)  
     OriGene Antibodies for NLN   OriGene shRNA RFP for NLN  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NLN   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLN  
     OriGene Protein Over-expression Lysate for NLN   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NLN   OriGene 3'-UTR Clone for NLN  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLN   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLN  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for NLN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NLN   OriGene Custom Protein Services for NLN  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NLN
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLN
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLN
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NLN
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLN
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLN
     GenScript Custom Purified and Recombinant Proteins Services for NLN GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for NLN
     GenScript Custom Assay Services for NLN GenScript Custom Superior Antibodies Services for NLN
     GenScript Custom overexpressing Cell Line Services for NLN CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NLN promoter
     Search Chromatin IP Primers for NLN
     RT2 qPCR Primer Assay in human, mouse, rat NLN
     Search GNC Networks for NLN
     SABiosciences Custom PCR Arrays for NLN
     Search Tocris compounds for NLN
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for NLN
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NLN antibodies
     NLN proteins
     NLN lysates
     Antibodies for NLN
     See all of Abcam's Antibodies, Kits and Proteins for NLN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NLN Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NLN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLN
     SwitchGear 3'UTR luciferase reporter plasmids for NLN
     SwitchGear Promoter luciferase reporter plasmids for NLN
     Search ThermoFisher Antibodies for NLN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLN
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NLN
    Sirion Biotech Customized:
     stable knockdown cell line services for NLN
     inducible knockdown cell line services for NLN
     design and validation of potent shRNA sequences against NLN
     adenovirus for potent knockdown of NLN
     adenovirus for overexpression of NLN
     stable overexpressing cell line services for NLN
     inducible overexpressing cell line services for NLN
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NLN gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4