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Aliases for NLN Gene

Aliases for NLN Gene

  • Neurolysin 2 3 5
  • Neurotensin Endopeptidase 2 3 4
  • Neurolysin (Metallopeptidase M3 Family) 2 3
  • Mitochondrial Oligopeptidase M 3 4
  • Angiotensin Binding Protein 2 3
  • Microsomal Endopeptidase 3 4
  • EC 4 61
  • AGTBP 3 4
  • MEP 3 4
  • Angiotensin-Binding Protein 4
  • Neurolysin, Mitochondrial 3
  • Endopeptidase 24.16 3
  • EC 3.4.24 61
  • KIAA1226 4
  • EP24.16 3
  • MOP 3

External Ids for NLN Gene

Previous HGNC Symbols for NLN Gene


Previous GeneCards Identifiers for NLN Gene

  • GC05P065169
  • GC05P066556
  • GC05P064988
  • GC05P065033
  • GC05P065053
  • GC05P065018
  • GC05P061976

Summaries for NLN Gene

Entrez Gene Summary for NLN Gene

  • This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]

GeneCards Summary for NLN Gene

NLN (Neurolysin) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include metalloendopeptidase activity and peptide binding. An important paralog of this gene is THOP1.

UniProtKB/Swiss-Prot for NLN Gene

  • Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.

Gene Wiki entry for NLN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLN Gene

Genomics for NLN Gene

Regulatory Elements for NLN Gene

Enhancers for NLN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F065790 1.1 ENCODE 14.4 +68.3 68305 0.6 KLF1 PKNOX1 FOXA3 ZIC2 TBX3 ZFHX2 ZNF274 CBX5 RFX3 PBX2 SGTB NLN ERBIN ENSG00000252904 GC05P065768 ENSG00000269961
GH05F065731 0.9 FANTOM5 Ensembl 12.8 +10.1 10105 1.0 ERBIN NLN SGTB SREK1 LOC100419549
GH05F065720 0.2 ENCODE 12.4 -0.1 -50 2.9 PKNOX1 CREB3L1 ZNF133 ARID4B SIN3A GLI4 DMAP1 ZNF48 ZNF2 YY1 NLN CENPK PPWD1 ENSG00000250081 TRIM23
GH05F065727 1.1 Ensembl ENCODE 12.2 +5.4 5405 1.2 PKNOX1 IKZF1 NLN TRAPPC13 ENSG00000250081 SGTB LOC100419549
GH05F065730 0.6 Ensembl 12.1 +8.7 8706 0.6 ZNF316 ZSCAN29 EMSY MAFK NLN LOC100419549 SGTB
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NLN on UCSC Golden Path with GeneCards custom track

Promoters for NLN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001281758 4 3601 PKNOX1 CREB3L1 ZNF133 ZFP64 ARID4B SIN3A GLI4 DMAP1 ZNF48 ZNF2

Genomic Location for NLN Gene

65,722,196 bp from pter
65,871,725 bp from pter
149,530 bases
Plus strand

Genomic View for NLN Gene

Genes around NLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLN Gene

Proteins for NLN Gene

  • Protein details for NLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neurolysin, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q9ULJ4

    Protein attributes for NLN Gene

    704 amino acids
    Molecular mass:
    80652 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for NLN Gene

Selected DME Specific Peptides for NLN Gene


Post-translational modifications for NLN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NLN Gene

Protein Domains for NLN Gene

Suggested Antigen Peptide Sequences for NLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M3 family.
  • Belongs to the peptidase M3 family.
genes like me logo Genes that share domains with NLN: view

No data available for Gene Families for NLN Gene

Function for NLN Gene

Molecular function for NLN Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage in neurotensin: 10-Pro- -Tyr-11.
UniProtKB/Swiss-Prot Function:
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.

Enzyme Numbers (IUBMB) for NLN Gene

Gene Ontology (GO) - Molecular Function for NLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IBA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with NLN: view
genes like me logo Genes that share phenotypes with NLN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NLN

miRNA for NLN Gene

miRTarBase miRNAs that target NLN

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLN Gene

Localization for NLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLN Gene

Mitochondrion intermembrane space. Cytoplasm.

Subcellular locations from

Jensen Localization Image for NLN Gene COMPARTMENTS Subcellular localization image for NLN gene
Compartment Confidence
mitochondrion 5
cytosol 4
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for NLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005758 mitochondrial intermembrane space IEA,IBA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with NLN: view

Pathways & Interactions for NLN Gene

genes like me logo Genes that share pathways with NLN: view

Pathways by source for NLN Gene

Gene Ontology (GO) - Biological Process for NLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006111 regulation of gluconeogenesis IEA --
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process IBA --
GO:1902809 regulation of skeletal muscle fiber differentiation IEA --
genes like me logo Genes that share ontologies with NLN: view

No data available for SIGNOR curated interactions for NLN Gene

Drugs & Compounds for NLN Gene

(3) Drugs for NLN Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2231
Bradykinin Pharma Full agonist, Agonist Endogenous agonist at bradykinin receptors (B2 > B1) 50

(4) Additional Compounds for NLN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NLN: view

Transcripts for NLN Gene

Unigene Clusters for NLN Gene

Neurolysin (metallopeptidase M3 family):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - - - - - -
SP2: - - -
SP3: - - - - -

Relevant External Links for NLN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NLN Gene

Protein differential expression in normal tissues from HIPED for NLN Gene

This gene is overexpressed in Brain (35.0) and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NLN Gene

Protein tissue co-expression partners for NLN Gene

NURSA nuclear receptor signaling pathways regulating expression of NLN Gene:


SOURCE GeneReport for Unigene cluster for NLN Gene:

genes like me logo Genes that share expression patterns with NLN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NLN Gene

Orthologs for NLN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NLN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NLN 34 35
  • 99.34 (n)
(Canis familiaris)
Mammalia NLN 34 35
  • 91.94 (n)
(Bos Taurus)
Mammalia NLN 34 35
  • 90.91 (n)
(Mus musculus)
Mammalia Nln 34 16 35
  • 87.15 (n)
(Rattus norvegicus)
Mammalia Nln 34
  • 86.44 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
-- 35
  • 76 (a)
(Monodelphis domestica)
Mammalia NLN 35
  • 64 (a)
(Gallus gallus)
Aves NLN 34 35
  • 75.54 (n)
(Anolis carolinensis)
Reptilia NLN 35
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nln 34
  • 68.96 (n)
(Danio rerio)
Actinopterygii nln 35
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11771 36 35
  • 24 (a)
(Caenorhabditis elegans)
Secernentea ZK550.3 35
  • 16 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C00572g 34
  • 49.35 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRD1 34 35
  • 46.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4245 35
  • 58 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06618 34
  • 46.76 (n)
Species where no ortholog for NLN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NLN Gene

Gene Tree for NLN (if available)
Gene Tree for NLN (if available)

Paralogs for NLN Gene

Variants for NLN Gene

Sequence variations from dbSNP and Humsavar for NLN Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10037028 -- 65,795,241(+) TGCAA(A/G)GCTAG intron-variant
rs10055106 -- 65,785,698(+) ATACA(C/T)ACAGT intron-variant
rs10061096 -- 65,802,885(+) tctcc(A/G)cagct intron-variant
rs10063578 -- 65,744,317(+) CTAAT(A/G)TCTCT intron-variant
rs10068333 -- 65,736,364(+) TATTA(C/T)AAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLN Gene

Variant ID Type Subtype PubMed ID
esv2676386 CNV deletion 23128226
esv2730277 CNV deletion 23290073
esv29005 CNV gain 19812545
esv3566030 CNV deletion 23714750
esv3605303 CNV loss 21293372
nsv507256 OTHER sequence alteration 20534489
nsv820637 CNV deletion 20802225
nsv980652 CNV duplication 23825009

Variation tolerance for NLN Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.42; 77.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NLN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLN Gene

Disorders for NLN Gene

Relevant External Links for NLN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NLN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLN Gene

Publications for NLN Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. (PMID: 17251185) Lim E.J. … Rodgers D.W. (J. Biol. Chem. 2007) 3 22 64
  5. Endopeptidases and 24.16 in endothelial cells: potential role in vasoactive peptide metabolism. (PMID: 12609826) Norman M.U. … Lew R.A. (Am. J. Physiol. Heart Circ. Physiol. 2003) 3 22 64

Products for NLN Gene

Sources for NLN Gene

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