Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NLN Gene

protein-coding   GIFtS: 60
GCID: GC05P065018

Neurolysin (Metallopeptidase M3 Family)

(Previous name: angiotensin binding protein)
(Previous symbol: AGTBP)
  Search for NLN
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Neurolysin (Metallopeptidase M3 Family)1 2     EC 3.4.24.163 8
AGTBP1 2 3 5     KIAA12263 5
Angiotensin Binding Protein1 2     EP24.162
Angiotensin-Binding Protein2 3     MOP2
Microsomal Endopeptidase2 3     Endopeptidase 24.162
Mitochondrial Oligopeptidase M2 3     Neurolysin, Mitochondrial2
Neurotensin Endopeptidase2 3     EC 3.4.248
MEP2 3     

External Ids:    HGNC: 160581   Entrez Gene: 574862   Ensembl: ENSG000001232137   OMIM: 6115305   UniProtKB: Q9BYT83   

Export aliases for NLN gene to outside databases

Previous GC identifers: GC05P065169 GC05P066556 GC05P064988 GC05P065033 GC05P065053 GC05P061976


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NLN Gene:
This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11
bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely
involved in the termination of the neurotensinergic signal in the central nervous system and in the
gastrointestinal tract.(provided by RefSeq, Jun 2010)

GeneCards Summary for NLN Gene:
NLN (neurolysin (metallopeptidase M3 family)) is a protein-coding gene. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is THOP1.

UniProtKB/Swiss-Prot: NEUL_HUMAN, Q9BYT8
Function: Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity)

Gene Wiki entry for NLN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NLN gene promoter:
         GR   STAT1   Lmo2   STAT1beta   STAT1alpha   E47   Max   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLN promoter sequence
   Search Chromatin IP Primers for NLN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12.3

NLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLN gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P065018:  view genomic region     (about GC identifiers)

Start:
65,018,023 bp from pter      End:
65,167,553 bp from pter
Size:
149,531 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NEUL_HUMAN, Q9BYT8 (See protein sequence)
Recommended Name: Neurolysin, mitochondrial precursor  
Size: 704 amino acids; 80652 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: Q9ULJ4

Explore the universe of human proteins at neXtProt for NLN: NX_Q9BYT8

Explore proteomics data for NLN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NLN (Q9BYT8) (see all 21)
     LQETCDL  ASTEADK  RNGLHLP  THADFVLE 


    See NLN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065777.1  
    ENSEMBL proteins: 
     ENSP00000370372   ENSP00000423214   ENSP00000422822   ENSP00000427417   ENSP00000426959  

    NLN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NLN (Neurolysin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NLN
    OriGene Protein Over-expression Lysate for NLN
    OriGene MassSpec for NLN
    OriGene Custom Protein Services for NLN
    GenScript Custom Purified and Recombinant Proteins Services for NLN
    Novus Biologicals NLN Protein
    Novus Biologicals NLN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NLN

     
    Search eBioscience for Proteins for NLN 

    NLN Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NLN (Neurolysin)
    OriGene Antibodies for NLN
    OriGene Custom Antibody Services for NLN
    Novus Biologicals NLN Antibodies
    Abcam antibodies for NLN
    Cloud-Clone Corp. Antibodies for NLN
    ThermoFisher Antibodies for NLN
    LSBio Antibodies in human, mouse, rat for NLN

    NLN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NLN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NLN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NLN
    Cloud-Clone Corp. CLIAs for NLN
    Search eBioscience for ELISAs for NLN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR024079 MetalloPept_cat_dom
     IPR024077 Neurolysin/TOP_dom2
     IPR001567 Pept_M3A_M3B
     IPR024080 Neurolysin/TOP_N

    Graphical View of Domain Structure for InterPro Entry Q9BYT8

    ProtoNet protein and cluster: Q9BYT8

    1 Blocks protein domain: IPB001567 Peptidase M3

    UniProtKB/Swiss-Prot: NEUL_HUMAN, Q9BYT8
    Similarity: Belongs to the peptidase M3 family


    Find genes that share domains with NLN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEUL_HUMAN, Q9BYT8
    Function: Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity)
    Catalytic activity: Preferential cleavage in neurotensin: 10-Pro- -Tyr-11

         Enzyme Numbers (IUBMB): EC 3.4.24.161 2 EC 3.4.242

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0042277peptide binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with NLN           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NLN:
     Decreased viability  Increased G2M DNA content 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Nln):
     no phenotypic analysis 

    Find genes that share phenotypes with NLN           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NLN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NLN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NLN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NLN

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NLN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NLN (see all 88):
    hsa-miR-579 hsa-miR-605 hsa-miR-128 hsa-miR-632 hsa-miR-374a hsa-miR-3909 hsa-miR-1231 hsa-miR-27a
    SwitchGear 3'UTR luciferase reporter plasmidNLN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NLN
    Predesigned siRNA for gene silencing in human, mouse, rat NLN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NLN

    Clone
    Products:
         
    OriGene clones in human, mouse for NLN (see all 7)
    OriGene ORF clones in mouse, rat for NLN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for NLN
    Sino Biological Human cDNA Clone for NLN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NLN
    Browse ESI BIO Cell Lines and PureStem Progenitors for NLN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NEUL_HUMAN, Q9BYT8: Mitochondrion intermembrane space (By similarity). Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion3
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005758mitochondrial intermembrane space IEA--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with NLN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NLN About    
    See pathways by source

    SuperPathContained pathways About
    1Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Renin-angiotensin system0.37


    Find genes that share SuperPaths with NLN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for NLN):
        Renin-angiotensin system

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NLN
    Interactions:

        Search GeneGlobe Interaction Network for NLN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for NLN (Q9BYT83 ENSP000003703724) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTSP309903, ENSP000002560104I2D: score=1 STRING: ENSP00000256010
    CLN3Q132863I2D: score=1 
    CBX1ENSP000002256034STRING: ENSP00000225603
    EIF4BENSP000002620564STRING: ENSP00000262056
    FXNENSP000003664824STRING: ENSP00000366482
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with NLN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NLN (NEUL)

    7 HMDB Compounds for NLN    About this table
    CompoundSynonyms CAS #PubMed Ids
    BradykininCallidin I (see all 5)58-82-2--
    Dynorphin ATyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln;dynorphin A 1-17 80448-90-4--
    Dynorphin A 1-8Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile;dynorphin A (1-8);dynorphin A fragment 1-8 75790-53-3--
    Dynorphin A 9-17dynorphin A (9-17);Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln ----
    Neurotensin 1-10pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro;neurotensin (1-10);neurotensin fragment 1-10 ----
    Neurotensin 11-13Tyr-Ile-Leu;neurotensin (11-13);neurotensin fragment 11-13 ----
    ZincZinc (see all 2)7440-66-6--

    5 Novoseek inferred chemical compound relationships for NLN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thimet 96.3 30 11355859 (2), 12706825 (2), 17313369 (2), 10235115 (2) (see all 17)
    n-(2,4-dinitrophenyl)ethylenediamine 93 2 12199711 (1), 17313369 (1)
    anthranilate 61.2 1 12199711 (1)
    phosphorus 19.3 3 17284829 (2), 17277461 (1)
    cysteine 5.4 1 12968080 (1)



    Find genes that share compounds with NLN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NLN gene: 
    NM_020726.4  

    Unigene Cluster for NLN:

    Neurolysin (metallopeptidase M3 family)
    Hs.247460  [show with all ESTs]
    Unigene Representative Sequence: NM_020726
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380985(uc003juf.3) ENST00000502464(uc010iww.3) ENST00000514991
    ENST00000506539(uc003jue.3) ENST00000506799 ENST00000506677 ENST00000511299
    ENST00000509935 ENST00000507201 ENST00000515595
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NLN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NLN (see all 88):
    hsa-miR-579 hsa-miR-605 hsa-miR-128 hsa-miR-632 hsa-miR-374a hsa-miR-3909 hsa-miR-1231 hsa-miR-27a
    SwitchGear 3'UTR luciferase reporter plasmidNLN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NLN
    Predesigned siRNA for gene silencing in human, mouse, rat NLN
    Clone
    Products:
         
    OriGene clones in human, mouse for NLN (see all 7)
    OriGene ORF clones in mouse, rat for NLN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for NLN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLN
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NLN
    OriGene qSTAR qPCR primer pairs in human, mouse for NLN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NLN
      QuantiTect SYBR Green Assays in human, mouse, rat NLN
      QuantiFast Probe-based Assays in human, mouse, rat NLN

    Additional mRNA sequence: 

    AB033052.2 AJ300837.1 AK027602.1 AK096416.1 AK292803.1 AL834241.1 BC001644.2 BC004985.1 

    9 DOTS entries:

    DT.120812726  DT.413015  DT.312876  DT.100795391  DT.120812776  DT.120812703  DT.120812774  DT.120812688 
    DT.120812750 

    Selected AceView cDNA sequences (see all 188):

    AI687231 CB143952 Z32885 AI300009 BG249192 AA515414 BP377461 BM472616 
    AB033052 BE302168 BU688683 CR620384 BC001644 BE207850 BM678776 BE502864 
    C00452 BC004985 AI669585 BE018578 AA557562 CR613085 AA621092 BM907261 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NLN (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:        -                             -                       -                       -     -                       -                     
    SP2:        -                             -                       -                                                                           
    SP3:                                                              -                 -     -     -                       -                     
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for NLN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NLN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NLN Expression
    About this image

    NLN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NLN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247460
        Custom PCR Arrays for NLN
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NLN
    OriGene qSTAR qPCR primer pairs in human, mouse for NLN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NLN
    QuantiTect SYBR Green Assays in human, mouse, rat NLN
    QuantiFast Probe-based Assays in human, mouse, rat NLN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NLN gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nln1 , 5 neurolysin (metallopeptidase M3 family)1, 5 87.15(n)1
    90.33(a)1
      13 (56.16 cM)5
    758051  NM_029447.21  NP_083723.11 
     1040234395 
    chicken
    (Gallus gallus)
    Aves NLN1 neurolysin (metallopeptidase M3 family) 75.54(n)
    77.99(a)
      427167  XM_424755.3  XP_424755.2 
    lizard
    (Anolis carolinensis)
    Reptilia NLN6
    neurolysin (metallopeptidase M3 family)
    74(a)
    1 ↔ 1
    2(10784892-10817821)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nln1 neurolysin (metallopeptidase M3 family) 68.96(n)
    68.71(a)
      100158603  XM_002934190.2  XP_002934236.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nln6
    neurolysin (metallopeptidase M3 family)
    57(a)
    1 ↔ 1
    10(15437164-15476159) ENSDARG00000019233
    fruit fly
    (Drosophila melanogaster)
    Insecta CG117713 oligopeptidase A 24(a)   96B10   --
    worm
    (Caenorhabditis elegans)
    Secernentea ZK550.36
    Protein ZK550.3 (ZK550.3) mRNA, complete cds
    16(a)
    1 → many
    IV(17250131-17254964) WBGene00013997
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRD11 PRD1 46.54(n)
    36.67(a)
      850301   NP_009874.1 


    ENSEMBL Gene Tree for NLN (if available)
    TreeFam Gene Tree for NLN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NLN gene
    THOP12  
    Selected SIMAP similar genes for NLN using alignment to 5 protein entries:     NEUL_HUMAN (see all proteins) (see all similar genes):
    DKFZp564F123    NDUFS3    RRM2B    UBE2B    MRPL45    TMX3
    TUBA1C    ZNF66    RHBG    SLC24A1    HEXDC    NDC80
    ASCC1    FANCA    SH2B3    UBE2V2    ZNF114    ACTR10

    Find genes that share paralogs with NLN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NLN (see all 1945)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs109400471,2
    C,A,H--65020088(+) ccattA/Gcttcc 1 -- int14Minor allele frequency- G:0.29NA WA EA 360
    rs801242681,2
    C--65020175(+) GACAAC/G/TATTTG 1 -- int12CSA WA 120
    rs787277681,2
    C--65020176(+) ACAATA/GTTTGT 1 -- int10--------
    rs747406311,2
    C--65020178(+) AATATC/TTGTCC 1 -- int10--------
    rs1413096701,2
    --65020220(+) TTAAGA/GTTTAT 1 -- int10--------
    rs1147149211,2
    C,F--65020254(+) TTTCCT/CTTTTA 1 -- int11Minor allele frequency- C:0.03NA 120
    rs1140662301,2
    C,F--65020370(+) TATGAT/CCATTA 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1858944221,2
    --65020384(+) TGCACA/GTGTCT 1 -- int10--------
    rs1902211801,2
    --65020455(+) GAGTCA/GTAGGA 1 -- int10--------
    rs1450842871,2
    --65020468(+) GTACTA/GTGTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for NLN (65018023 - 65167553 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NLN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730277CNV Deletion23290073
    esv2676386CNV Deletion23128226
    nsv820637CNV Deletion20802225
    nsv507256CNV Insertion20534489
    esv29005CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NLN
    DNA2.0 Custom Variant and Variant Library Synthesis for NLN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611530    OMIM disorders: --


    Find genes that share disorders with NLN           About GenesLikeMe

    Genetic Association Database (GAD): NLN
    Human Genome Epidemiology (HuGE) Navigator: NLN (2 documents)

    Export disorders for NLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NLN gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with NLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    5. Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. (PubMed id 17251185)1, 9 Lim E.J....Rodgers D.W. (J. Biol. Chem. 2007)
    6. Confocal microscopy reveals thimet oligopeptidase (EC 3.4.24.15) and neurolysin (EC 3.4.24.16) in the classical secretory pathway. (PubMed id 10235115)1, 9 Garrido P.A....Beaudet A. (DNA Cell Biol. 1999)
    7. Endopeptidases 3.4.24.15 and 24.16 in endothelial cells: potential role in vasoactive peptide metabolism. (PubMed id 12609826)1, 9 Norman M.U....Lew R.A. (Am. J. Physiol. Heart Circ. Physiol. 2003)
    8. Neuropeptide specificity and inhibition of recombinant isoforms of the endopeptidase 3.4.24.16 family: comparison with the related recombinant endopeptidase 3.4.24.15. (PubMed id 9735321)1, 9 Rioli V....Ferro E.S. (Biochem. Biophys. Res. Commun. 1998)
    9. Stably transfected human cells overexpressing rat brain endopeptidase 3.4.24.16: biochemical characterization of the activity and expression of soluble and membrane-associated counterparts. (PubMed id 9003076)1, 9 Vincent B....Checler F. (J. Neurochem. 1997)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57486 HGNC: 16058 AceView: NLN Ensembl:ENSG00000123213 euGenes: HUgn57486
    ECgene: NLN Kegg: 57486 H-InvDB: NLN

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1226

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NLN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NLN gene:
    Search GeneIP for patents involving NLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for NLN (Neurolysin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for NLN (Neurolysin)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NLN   OriGene RNAi products in human, mouse, rat for NLN  
     OriGene qPCR primer pairs and template standards for NLN   OriGene Protein Over-expression Lysate for NLN  
     OriGene MassSpec something-or-other for NLN   OriGene clones in human, mouse for NLN  
     OriGene qSTAR qPCR primer pairs in human, mouse for NLN   OriGene Purified Protein for NLN  
     OriGene ORF clones in mouse, rat for NLN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NLN   OriGene Custom Protein Services for NLN  

     
     
     Block miRNA regulation of human, mouse, rat NLN using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NLN
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NLN Predesigned siRNA for gene silencing in human, mouse, rat NLN
     QuantiFast Probe-based Assays in human, mouse, rat NLN QuantiTect SYBR Green Assays in human, mouse, rat NLN
     Custom PCR Arrays for NLN Search Chromatin IP Primers for NLN
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NLN  Search GeneGlobe Interaction Network for NLN
     Regulatory tfbs in NLN promoter
     GenScript Custom Purified and Recombinant Proteins Services for NLN GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for NLN
     GenScript Custom Assay Services for NLN GenScript Custom overexpressing Cell Line Services for NLN
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NLN (NEUL)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for NLN
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NLN antibodies
     NLN proteins
     NLN lysates
     Antibodies for NLN
     See all of Abcam's Antibodies, Kits and Proteins for NLN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NLN
     Antibodies for NLN
     ELISAs for NLN
     CLIAs for NLN



     Browse ESI BIO Cell Lines and PureStem Progenitors for NLN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLN
     SwitchGear 3'UTR luciferase reporter plasmids for NLN
     SwitchGear Promoter luciferase reporter plasmids for NLN
     ThermoFisher Antibodies for NLN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLN
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NLN
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NLN
     LSBio Antibodies in human, mouse, rat for NLN
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NLN
      Search eBioscience for proteins for NLN
      Search eBioscience for elisas for NLN
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NLN gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4