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Aliases for NLN Gene

Aliases for NLN Gene

  • Neurolysin 2 3
  • Neurolysin (Metallopeptidase M3 Family) 2 3 5
  • Neurotensin Endopeptidase 2 3 4
  • Mitochondrial Oligopeptidase M 3 4
  • Angiotensin Binding Protein 2 3
  • Angiotensin-Binding Protein 3 4
  • Microsomal Endopeptidase 3 4
  • EC 3.4.24.16 4 63
  • AGTBP 3 4
  • MEP 3 4
  • Endopeptidase 24.16 3
  • EC 3.4.24 63
  • KIAA1226 4
  • EP24.16 3
  • MOP 3

External Ids for NLN Gene

Previous HGNC Symbols for NLN Gene

  • AGTBP

Previous GeneCards Identifiers for NLN Gene

  • GC05P065169
  • GC05P066556
  • GC05P064988
  • GC05P065033
  • GC05P065053
  • GC05P065018
  • GC05P061976

Summaries for NLN Gene

Entrez Gene Summary for NLN Gene

  • This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]

GeneCards Summary for NLN Gene

NLN (Neurolysin) is a Protein Coding gene. Among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. GO annotations related to this gene include metalloendopeptidase activity and peptide binding. An important paralog of this gene is THOP1.

UniProtKB/Swiss-Prot for NLN Gene

  • Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.

Gene Wiki entry for NLN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLN Gene

Genomics for NLN Gene

Regulatory Elements for NLN Gene

Promoters for NLN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NLN on UCSC Golden Path with GeneCards custom track

Genomic Location for NLN Gene

Chromosome:
5
Start:
65,722,196 bp from pter
End:
65,871,725 bp from pter
Size:
149,530 bases
Orientation:
Plus strand

Genomic View for NLN Gene

Genes around NLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLN Gene

Proteins for NLN Gene

  • Protein details for NLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYT8-NEUL_HUMAN
    Recommended name:
    Neurolysin, mitochondrial
    Protein Accession:
    Q9BYT8
    Secondary Accessions:
    • Q9ULJ4

    Protein attributes for NLN Gene

    Size:
    704 amino acids
    Molecular mass:
    80652 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for NLN Gene

Proteomics data for NLN Gene at MOPED

Post-translational modifications for NLN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLN Gene

Antibody Products

Domains & Families for NLN Gene

Protein Domains for NLN Gene

Suggested Antigen Peptide Sequences for NLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYT8

UniProtKB/Swiss-Prot:

NEUL_HUMAN :
  • Belongs to the peptidase M3 family.
Family:
  • Belongs to the peptidase M3 family.
genes like me logo Genes that share domains with NLN: view

No data available for Gene Families for NLN Gene

Function for NLN Gene

Molecular function for NLN Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage in neurotensin: 10-Pro- -Tyr-11.
UniProtKB/Swiss-Prot Function:
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.

Enzyme Numbers (IUBMB) for NLN Gene

Gene Ontology (GO) - Molecular Function for NLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NLN: view
genes like me logo Genes that share phenotypes with NLN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NLN

miRNA for NLN Gene

miRTarBase miRNAs that target NLN

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLN Gene

Localization for NLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLN Gene

Mitochondrion intermembrane space. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLN Gene COMPARTMENTS Subcellular localization image for NLN gene
Compartment Confidence
mitochondrion 5
cytosol 4
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for NLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with NLN: view

Pathways & Interactions for NLN Gene

genes like me logo Genes that share pathways with NLN: view

Pathways by source for NLN Gene

1 KEGG pathway for NLN Gene

Gene Ontology (GO) - Biological Process for NLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with NLN: view

No data available for SIGNOR curated interactions for NLN Gene

Drugs & Compounds for NLN Gene

(3) Drugs for NLN Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1477
Bradykinin Pharma Full agonist, Agonist Endogenous agonist at bradykinin receptors (B2 > B1) 47

(4) Additional Compounds for NLN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NLN: view

Transcripts for NLN Gene

Unigene Clusters for NLN Gene

Neurolysin (metallopeptidase M3 family):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NLN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - - - - - -
SP2: - - -
SP3: - - - - -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for NLN Gene

GeneLoc Exon Structure for
NLN
ECgene alternative splicing isoforms for
NLN

Expression for NLN Gene

mRNA expression in normal human tissues for NLN Gene

Protein differential expression in normal tissues from HIPED for NLN Gene

This gene is overexpressed in Brain (35.0) and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NLN Gene



SOURCE GeneReport for Unigene cluster for NLN Gene Hs.247460

genes like me logo Genes that share expression patterns with NLN: view

Protein tissue co-expression partners for NLN Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NLN Gene

Orthologs for NLN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NLN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NLN 35
  • 90.91 (n)
  • 93.32 (a)
NLN 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nln 35
  • 87.15 (n)
  • 90.33 (a)
Nln 16
Nln 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NLN 35
  • 99.34 (n)
  • 99.15 (a)
NLN 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NLN 36
  • 77 (a)
OneToOne
NLN 35
  • 91.94 (n)
  • 94.59 (a)
oppossum
(Monodelphis domestica)
Mammalia NLN 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nln 35
  • 86.44 (n)
  • 89.76 (a)
chicken
(Gallus gallus)
Aves NLN 35
  • 75.54 (n)
  • 77.99 (a)
NLN 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NLN 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nln 35
  • 68.96 (n)
  • 68.71 (a)
zebrafish
(Danio rerio)
Actinopterygii nln 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11771 37
  • 24 (a)
CG11771 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK550.3 36
  • 16 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C00572g 35
  • 49.35 (n)
  • 39.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRD1 35
  • 46.54 (n)
  • 36.67 (a)
PRD1 36
  • 34 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06618 35
  • 46.76 (n)
  • 33.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4245 36
  • 58 (a)
OneToMany
Species with no ortholog for NLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NLN Gene

ENSEMBL:
Gene Tree for NLN (if available)
TreeFam:
Gene Tree for NLN (if available)

Paralogs for NLN Gene

Paralogs for NLN Gene

genes like me logo Genes that share paralogs with NLN: view

Variants for NLN Gene

Sequence variations from dbSNP and Humsavar for NLN Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs6860508 - 65,822,910(+) ATGCT(C/T)CGTGA reference, missense
rs34063558 - 65,788,126(-) CTGGC(C/T)TAAAT reference, missense
rs6863012 - 65,788,274(+) ACTCA(A/G)GTATT reference, missense
rs2289884 - 65,788,408(-) AACAC(C/T)CTTGT reference, missense
rs34339013 - 65,758,760(-) AATAC(C/T)GAGCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NLN Gene

Variant ID Type Subtype PubMed ID
esv2676386 CNV Deletion 23128226
esv2730277 CNV Deletion 23290073
esv29005 CNV Gain 19812545
nsv820637 CNV Deletion 20802225
nsv507256 CNV Insertion 20534489

Variation tolerance for NLN Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.42; 77.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NLN Gene

HapMap Linkage Disequilibrium report
NLN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLN Gene

Disorders for NLN Gene

Relevant External Links for NLN

Genetic Association Database (GAD)
NLN
Human Genome Epidemiology (HuGE) Navigator
NLN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NLN

No disorders were found for NLN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLN Gene

Publications for NLN Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. (PMID: 17251185) Lim E.J. … Rodgers D.W. (J. Biol. Chem. 2007) 3 23
  3. Endopeptidases 3.4.24.15 and 24.16 in endothelial cells: potential role in vasoactive peptide metabolism. (PMID: 12609826) Norman M.U. … Lew R.A. (Am. J. Physiol. Heart Circ. Physiol. 2003) 3 23
  4. Confocal microscopy reveals thimet oligopeptidase (EC 3.4.24.15) and neurolysin (EC 3.4.24.16) in the classical secretory pathway. (PMID: 10235115) Garrido P.A. … Beaudet A. (DNA Cell Biol. 1999) 3 23
  5. Neuropeptide specificity and inhibition of recombinant isoforms of the endopeptidase 3.4.24.16 family: comparison with the related recombinant endopeptidase 3.4.24.15. (PMID: 9735321) Rioli V. … Ferro E.S. (Biochem. Biophys. Res. Commun. 1998) 3 23

Products for NLN Gene

Sources for NLN Gene

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