NLK Gene
protein-coding GIFtS: 62
GCID: GC17P026369
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nemo-like kinase(Previous name: nemo like kinase )
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Aliases
for NLK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nemo-Like Kinase1 2 3 | | LAK13 | | EC 2.7.11.243 8 | | Protein LAK13 | | Nemo Like Kinase1 | | EC 2.7.118 | | Serine/Threonine-Protein Kinase NLK2 | | |
Export aliases for NLK gene to outside databasesPrevious GC identifers: GC17P026225 GC17P028269 GC17P026515 GC17P026514 GC17P023393 GC17P022577 |
Summaries
for NLK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NLK_HUMAN, Q9UBE8Function: Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fatedetermination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1.The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histoneH3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis andpromotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-cateninsignaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of theTCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Togetherthese effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator ofthe Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of atranscriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family oftranscription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 andMYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited bydirect phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is inturn required for activation of NLK by MAP3K7/TAK1
Gene Wiki entry for NLK
|
Genomic Views
for NLK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NLK gene promoter:
E2F-4 E2F-3a E2F-5 p300 E2F-2 PPAR-gamma1 E2F PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NLK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2NLK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P026369: view genomic region
(about GC identifiers)
Start:
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26,368,763 bp from pter |
End:
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26,523,407 bp from pter |
Size:
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154,645 bases |
Orientation:
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plus strand |
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Proteins
for NLK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NLK_HUMAN, Q9UBE8 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase NLK Size: 527 amino acids; 58283 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer. Homodimerization is required for intermolecular autophosphorylation, kinase activation and nuclearlocalization (By similarity). May interact with components of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3ubiquitin-protein ligase complexes (By similarity). Interacts with LEF1, MEF2A, MYBL1 and MYBL2 (By similarity).Interacts with the upstream activating kinases HIPK2 and MAP3K7/TAK1. Interaction with MAP3K7/TAK1 seems to beindirect, and may be mediated by other proteins such as STAT3, TAB1 and TAB2. Interacts with and phosphorylates anumber of transcription factors including FOXO1, FOXO3, FOXO4, MYB, NOTCH1 and TCF7L2/TCF4. Interacts with DAPK3/ZIPK,and this interaction may disrupt interaction with transcription factors such as TCF7L2/TCF4. Forms a transcriptionalrepressor complex with CHD7, PPARG and SETDB1. Interacts with RNF138/NARF
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear. A smallerfraction is cytoplasmic (By similarity)
Sequence caution: Sequence=AAD56013.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAF04857.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=ABC40748.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG37718.1; Type=Erroneous initiation;Note=Translation N-terminally extended;
Secondary accessions: B2RCX1 Q2PNI9 Q6P2A3Explore the universe of human proteins at neXtProt for NLK: NX_Q9UBE8
Post-translational modifications:
Phosphorylated on Thr-298. Intermolecular autophosphorylation on Thr-298 activates the enzyme1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBE8
4/14 DME Specific Peptides for NLK (Q9UBE8) (see all 14)
NLK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057315.3
ENSEMBL proteins: ENSP00000384625 ENSP00000464656 ENSP00000433117
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NLK for ontologies About GeneDecksing
NLK Antibody Products:
Assay Products for NLK: |
Protein
Domains /
Families
for NLK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NLK for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9UBE8ProtoNet protein and cluster: Q9UBE8 1 Blocks protein family: IPB003527 MAP kinase
UniProtKB/Swiss-Prot: NLK_HUMAN, Q9UBE8Domain: Contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) issufficient for kinase activation. This mode of activation contrasts with that of classical MAP kinases, which containa TXY activation loop motif in which phosphorylation of both the threonine and tyrosine residues is required forkinase activationSimilarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamilySimilarity: Contains 1 protein kinase domain |
Function
for NLK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NLK_HUMAN, Q9UBE8Function: Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fatedetermination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1.The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histoneH3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis andpromotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-cateninsignaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of theTCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Togetherthese effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator ofthe Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of atranscriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family oftranscription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 andMYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited bydirect phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is inturn required for activation of NLK by MAP3K7/TAK1Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by dimerization and subsequent intermolecular autophosphorylation on Thr-298 (Bysimilarity). Activated by the non-canonical Wnt signaling pathway, in which WNT5A treatment leads to activation ofMAP3K7/TAK1 and HIPK2, which subsequently phosphorylates and activates this protein. Other cytokines such as IL6 mayalso activate this regulatory circuitEnzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLK (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NLK (NM_016231) | |  | Sino Biological Human cDNA Clone for NLK | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NLK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLK |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
NLK for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for NLK:
Animal Models:
7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Nlk):
NLK for phenotypes About GeneDecksing
|
Pathways & Interactions
for NLK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Wnt Signaling Pathway | | | 2 | MAPK signaling pathway | | | 3 | IL-6 Signaling Pathway | | | 4 | Noncanonical Wnt signaling pathway | | | 5 | C-MYB transcription factor network | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  R&D Systems Pathway for NLK
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NLK
5/7  BioSystems Pathways for NLK (see all 7)
3 
Kegg Pathways (Kegg details for NLK):
NLK for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NLK
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/52 Interacting proteins for NLK (Q9UBE81, 2, 3 ENSP000003846254) via UniProtKB, MINT, STRING, and/or I2D (see all 52)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
NLK for ontologies About GeneDecksing
|
Drugs & Compounds
for NLK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NLK for compounds About GeneDecksing
 Browse Tocris compounds for NLK
1 HMDB Compound for NLK About this table
2 Novoseek chemical compound relationships for NLK gene About this table
Search CenterWatch for drugs/clinical trials and news about NLK
|
Transcripts
for NLK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NLK gene: NM_016231.4 Unigene Cluster for NLK: Nemo-like kinase Hs.208759 [show with all ESTs]Unigene Representative Sequence: BC0646636 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000583517 ENST00000407008(uc010crj.3) ENST00000582037 ENST00000496808
ENST00000584188 ENST00000584878
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLK (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NLK (NM_016231) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NLK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLK |
Additional cDNA sequence: AF180819.1 AF197898.1 AK024686.1 AK130232.1 AK315315.1 AL161970.1 BC064663.1 5 DOTS entries: DT.452078 DT.95175455 DT.86845958 DT.455470 DT.91902024 24/185 AceView cDNA sequences (see all 185): AA570309 BM723604 N44198 T15937 AA971118 BF448195 BE827564 AW614469 CK300968 BE045690 BE671404 AA252602 AI634825 AI651849 AA953549 AW451797 AI433836 W31812 AA425925 AI418499 AL711916 BU191328 BQ636970 BF222185
GeneLoc Exon Structure
|
Expression
for NLK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NLK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGATGATGA
About this image
See NLK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NLK
SOURCE GeneReport for Unigene cluster: Hs.208759
SABiosciences Expression via Pathway-Focused PCR Array including NLK:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NLK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLK |
Orthologs
for NLK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NLK gene from 8/33 species (see all 33) About this table
ENSEMBL Gene Tree for NLK (if available)
TreeFam Gene Tree for NLK (if available) |
Paralogs
for NLK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NLK gene
- MAPK42 MAPK32 MAPK72 MAPK152 MAPK62 MAPK12
18/47 SIMAP similar genes for NLK using alignment to 3 protein entries: NLK_HUMAN (see all proteins)
(see all similar genes):TXK DKFZp686O0215 MAPK14 MAPK11 MAPK1 DYRK4
MAPK8 MAPK3 MAPK13 NEK9 CDK7 STK11
CDC2 MAPK7 MAPK9 MAPK10 MOK RPS6KA2
NLK for paralogs About GeneDecksing
|
Genomic Variants
for NLK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NLK (26368763 - 26523407 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NLK: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLK |
|
Disorders
/ Diseases
for NLK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NLK for disorders About GeneDecksing
OMIM gene information: 609476
OMIM disorders: --
12  diseases for NLK: About MalaCardscolon cancer neurofibromatosis gastric cancer colorectal cancer
prostate cancer ataxia retinitis prostatitis
hepatitis malaria neuronitis carcinoma
2 Novoseek disease relationships for NLK gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| colon cancer |
27.7 |
6 |
12901858 (1), 14720327 (1), 20512928 (1) |
| cancer |
7.8 |
2 |
20512928 (1) |
Human Genome Epidemiology (HuGE) Navigator: NLK (7 documents)
Export disorders for NLK gene to outside databases
|
Publications
for NLK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NLK gene, integrated from 9 sources (see all 64):
(articles sorted by number of sources associating them with NLK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts. (PubMed id 10863097)1, 2, 3, 9 Kehrer-Sawatzki H....Krone W. (2000)
- STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. (PubMed id 15764709)1, 2, 9 Kojima H....Nakajima K. (2005)
- Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. (PubMed id 15082531)1, 2, 9 Kanei-Ishii C.... Ishii S. (2004)
- Regulation of FOXO1 by TAK1-Nemo-like kinase pathway. (PubMed id 20061393)1, 2, 9 Kim S....Chung J. (2010)
- A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. (PubMed id 17952062)1, 2, 9 Takada I....Kato S. (2007)
- Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4). (PubMed id 21454679)1, 2 Togi S.... Matsuda T. (2011)
- Oxidative stress-dependent regulation of Forkhead box O4 activity by nemo-like kinase. (PubMed id 20874444)1, 2 Szypowska A.A....Burgering B.M.T. (2011)
- Nemo-like kinase suppresses Notch signalling by inter fering with formation of the Notch active transcriptional complex. (PubMed id 20118921)1, 2 Ishitani T....Itoh M. (2010)
- NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). (PubMed id 16714285)1, 2 Yamada M.... Shibuya H. (2006)
- Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. (PubMed id 15004007)1, 2 Ohkawara B.... Shibuya H. (2004)
|
External Searches for NLK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NLK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NLK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NLK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NLK | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NLK gene:
Search GeneIP for patents involving NLK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NLK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for NLK | | OriGene shRNA RFP for NLK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NLK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLK | | | OriGene Protein Over-expression Lysate for NLK | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NLK | | OriGene 3'-UTR Clone for NLK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NLK | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NLK | | OriGene Custom Protein Services for NLK | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NLK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NLK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLK |
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| | | | Search Tocris compounds for NLK |
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 | | | NLK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLK |
|  |  |  | | | | ThermoFisher Antibody for NLK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLK |
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