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NLGN4Y Gene

protein-coding   GIFtS: 54
GCID: GC0YP016634

Neuroligin 4, Y-Linked

(Previous names: neuroligin 4, Y linked)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuroligin 4, Y-Linked1 2
KIAA09513 5
Neuroligin 4, Y Linked1
Neuroligin-4, Y-Linked2
Neuroligin Y3

External Ids:    HGNC: 155291   Entrez Gene: 228292   Ensembl: ENSG000001652467   OMIM: 4000285   UniProtKB: Q8NFZ33   

Export aliases for NLGN4Y gene to outside databases

Previous GC identifers: GC0YU990048 GC0YM9A0047 GC0XM005269 GC0YP015072 GC0YP015145 GC0YP011242


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NLGN4Y Gene:
This gene encodes a type I membrane protein that belongs to the family of neuroligins, which are cell adhesion
molecules present at the postsynaptic side of the synapse, and may be essential for the formation of functional
synapses. Alternatively spliced transcript variants have been found for this gene.(provided by RefSeq, Mar 2011)

GeneCards Summary for NLGN4Y Gene:
NLGN4Y (neuroligin 4, Y-linked) is a protein-coding gene. Diseases associated with NLGN4Y include asperger syndrome, and autistic disorder. GO annotations related to this gene include neurexin family protein binding and receptor activity. An important paralog of this gene is NLGN1.

UniProtKB/Swiss-Prot: NLGNY_HUMAN, Q8NFZ3
Function: Putative neuronal cell surface protein involved in cell-cell-interactions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000024.10  NT_011875.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NLGN4Y
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLGN4Y promoter sequence
   Search Chromatin IP Primers for NLGN4Y

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NLGN4Y


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yq11.221   Ensembl cytogenetic band:  Yq11.221   HGNC cytogenetic band: Yq11.221

NLGN4Y Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLGN4Y gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YP016634:  view genomic region     (about GC identifiers)

Start:
16,634,488 bp from pter      End:
16,957,530 bp from pter
Size:
323,043 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NLGNY_HUMAN, Q8NFZ3 (See protein sequence)
Recommended Name: Neuroligin-4, Y-linked precursor  
Size: 816 amino acids; 92021 Da
Subunit: Homodimer. Interacts with NRXN1 in a calcium-dependent manner. Interacts through its C-terminus with
DLG4/PSD-95 third PDZ domain (By similarity)
Sequence caution: Sequence=BAA76795.2; Type=Erroneous initiation;
Secondary accessions: F5H6W0 Q14D08 Q7Z3T5 Q8N5B6 Q9Y2F8
Alternative splicing: 4 isoforms:  Q8NFZ3-1   Q8NFZ3-2   Q8NFZ3-3   Q8NFZ3-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NLGN4Y: NX_Q8NFZ3

Explore proteomics data for NLGN4Y at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn102, Asn511
  • Modification sites at PhosphoSitePlus

  • See NLGN4Y Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001157710.1  NP_001193779.1  NP_055708.3  

    ENSEMBL proteins: 
     ENSP00000372325   ENSP00000348169   ENSP00000372320   ENSP00000342535   ENSP00000412638  
     ENSP00000297967  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000460 Neuroligin
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB

    Graphical View of Domain Structure for InterPro Entry Q8NFZ3

    ProtoNet protein and cluster: Q8NFZ3

    1 Blocks protein domain: IPB000460 Neuroligin signature

    UniProtKB/Swiss-Prot: NLGNY_HUMAN, Q8NFZ3
    Similarity: Belongs to the type-B carboxylesterase/lipase family


    NLGN4Y for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NLGNY_HUMAN, Q8NFZ3
    Function: Putative neuronal cell surface protein involved in cell-cell-interactions

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IBA--
    GO:0005515protein binding IPI17292328
    GO:0016787hydrolase activity ----
    GO:0042043neurexin family protein binding IBA--
    GO:0050839cell adhesion molecule binding TAS18923512
         
    NLGN4Y for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NLGN4Y
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NLGN4Y
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    miRNA
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    miRTarBase miRNAs that target NLGN4Y:
    hsa-mir-335-5p (MIRT018830), hsa-mir-124-3p (MIRT023037)

    Block miRNA regulation of human, mouse, rat NLGN4Y using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NLGN4Y (see all 42):
    hsa-miR-607 hsa-miR-16-1* hsa-miR-3653 hsa-miR-570 hsa-miR-124 hsa-miR-9 hsa-miR-3658 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidNLGN4Y 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NLGNY_HUMAN, Q8NFZ3: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic
    cell membrane, postsynaptic density (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IBA--
    GO:0009986cell surface IBA--
    GO:0014069postsynaptic density IEA--
    GO:0016020membrane ----
    GO:0030054cell junction IEA--

    NLGN4Y for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NLGN4Y About    
    See pathways by source

    SuperPathContained pathways About
    1GABA signaling in brain
    GABA signaling in brain0.32



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NLGN4Y
    Interactions:

        Search GeneGlobe Interaction Network for NLGN4Y

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for NLGN4Y (ENSP000003425354) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRXN1ENSP000003851424STRING: ENSP00000385142
    NRXN2ENSP000002654594STRING: ENSP00000265459
    BMPR2ENSP000003637084STRING: ENSP00000363708
    DAB2ENSP000003133914STRING: ENSP00000313391
    MAGI2ENSP000003461514STRING: ENSP00000346151
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ----
    GO:0007158neuron cell-cell adhesion TAS18923512
    GO:0007416synapse assembly IBA--
    GO:0007612learning IMP18628683
    GO:0008152metabolic process ----

    NLGN4Y for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NLGN4Y (NLGNY)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NLGN4Y gene (3 alternative transcripts): 
    NM_001164238.1  NM_001206850.1  NM_014893.4  

    Unigene Cluster for NLGN4Y:

    Neuroligin 4, Y-linked
    Hs.439199  [show with all ESTs]
    Unigene Representative Sequence: NR_028319
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471252 ENST00000382872(uc004fte.2) ENST00000355905(uc004ftg.2)
    ENST00000382868(uc011nas.1) ENST00000476359(uc004ftf.2) ENST00000481089
    ENST00000339174(uc004fth.2) ENST00000413217 ENST00000297967(uc004fti.4)

    miRNA
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    Block miRNA regulation of human, mouse, rat NLGN4Y using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NLGN4Y (see all 42):
    hsa-miR-607 hsa-miR-16-1* hsa-miR-3653 hsa-miR-570 hsa-miR-124 hsa-miR-9 hsa-miR-3658 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidNLGN4Y 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NLGN4Y
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      QuantiTect SYBR Green Assays in human, mouse, rat NLGN4Y
      QuantiFast Probe-based Assays in human, mouse, rat NLGN4Y

    Additional mRNA sequence: 

    AB023168.1 AF376804.1 AK295117.1 BC032567.1 BC113525.1 BC113551.1 BX537428.1 NR_028319.1 
    NR_046355.1 

    5 DOTS entries:

    DT.75189473  DT.92424999  DT.100021787  DT.100779335  DT.120654855 

    Selected AceView cDNA sequences (see all 39):

    CD108831 BF060948 BQ002163 AI807783 AB023168 BX537428 BQ924832 AL120487 
    AX773943 BU727218 BM972838 AX773941 AF376804 BM722570 BE465446 BE857978 
    BX105854 NM_014893 BX510263 BC032567 BX280378 AW304721 BM679221 AA187847 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NLGN4Y    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9
    SP1:                                                                                          
    SP2:                                                                                          
    SP3:        -     -     -     -     -     -                                                   
    SP4:                                                                                          
    SP5:                                -     -                                                   


    ECgene alternative splicing isoforms for NLGN4Y

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NLGN4Y expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTGCAAA
    NLGN4Y Expression
    About this image

    NLGN4Y Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NLGN4Y Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.439199

    UniProtKB/Swiss-Prot: NLGNY_HUMAN, Q8NFZ3
    Tissue specificity: Expressed in fetal and adult brain, prostate and testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NLGN4Y gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia NLGN4X1 neuroligin 4, X-linked 87.83(n)
    96.94(a)
      607406  XM_005641073.1  XP_005641130.1 
    chicken
    (Gallus gallus)
    Aves NLGN4X1 neuroligin 4, X-linked 80.51(n)
    94.36(a)
      428006  NM_001171770.1  NP_001165241.1 
    lizard
    (Anolis carolinensis)
    Reptilia NLGN46
    Neuroligin 4; Uncharacterized protein
    91(a)
    1 → many
    3(116267805-116540581)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nlgn4x1 neuroligin 4, X-linked 75.97(n)
    89.79(a)
      100329189  NM_001171828.1  NP_001165299.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nlgn4b1 neuroligin 4b 70.74(n)
    78.24(a)
      100147967  NM_001166337.1  NP_001159809.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta neuroligin1 neuroligin 47.47(n)
    38.86(a)
      33962  NM_001258987.1  NP_001245916.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nlg-11 nlg-1 46.42(n)
    36.11(a)
      181484  NM_001270296.1  NP_001257225.1 


    ENSEMBL Gene Tree for NLGN4Y (if available)
    TreeFam Gene Tree for NLGN4Y (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NLGN4Y gene
    NLGN12  CES22  ACHE2  CES4A2  NLGN4X2  CES32  NLGN32  NLGN22  
    CES12  CEL2  CES5A2  BCHE2  
    6 SIMAP similar genes for NLGN4Y using alignment to 3 protein entries:     NLGNY_HUMAN (see all proteins):
    NLGN4X    DKFZp686F02202    NLGN3    nlgn1    NLGN1    NLGN2

    NLGN4Y for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NLGN4Y
    PGOHUM00000241175


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NLGN4Y (see all 2080)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr Y posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1117514831,2
    C--16632725(+) GTGCT-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00CSA 2
    rs97861031,2
    C--16633829(+) AAATAT/CAGGGG 3 -- us2k11Minor allele frequency- C:0.00WA 2
    rs97866981,2
    C,F--16636022(+) AAAAGC/TTGGAA 4 -- int1 us2k12Minor allele frequency- T:0.50WA NA 4
    rs173072941,2
    C,F--16638804(+) ATGGTA/GAGCAT 4 -- int13Minor allele frequency- G:0.09NA 66
    rs558231511,2
    C--16641085(+) TATTTC/TGCTAA 4 -- int10--------
    rs169804671,2
    C,F--16641386(+) TGGGAC/TGGGCA 4 -- int15Minor allele frequency- T:0.26NA WA 70
    rs561007301,2
    C--16641774(+) GTTTTC/TCTCAG 4 -- int10--------
    rs560672621,2
    C--16642381(+) TTTTTC/TTAAAT 4 -- int10--------
    rs773464071,2
    C--16642946(+) ACAGGC/TTCTTT 4 -- int10--------
    rs341658111,2
    C--16643296(+) AGCTGT/GTTAAT 4 -- int11Minor allele frequency- G:0.00NA 2

    HapMap Linkage Disequilibrium report for NLGN4Y (16634488 - 16884488 bp, first 250kb of NLGN4Y)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NLGN4Y:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510572CNV Loss20534489
    esv1500453OTHER Inversion17803354

    Human Gene Mutation Database (HGMD): NLGN4Y
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 400028    OMIM disorders: --

    6 diseases for NLGN4Y:    
    About MalaCards
    asperger syndrome    autistic disorder    tuberculosis    malaria
    neuronitis    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for NLGN4Y:
    Asperger syndrome     Autistic disorder

    NLGN4Y for disorders           About GeneDecksing

    Genetic Association Database (GAD): NLGN4Y
    Human Genome Epidemiology (HuGE) Navigator: NLGN4Y (2 documents)

    Export disorders for NLGN4Y gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NLGN4Y gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with NLGN4Y)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Association of Y chromosome haplotypes with autism. (PubMed id 19605777)1, 4 Serajee F.J. and Mahbubul Huq A.H. (J. Child Neurol. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (Nature 2003)
    5. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. (PubMed id 12669065)1, 2 Jamain S.... Van Maldergem L. (Nat. Genet. 2003)
    6. Analysis of the neuroligin 4Y gene in patients with autism. (PubMed id 18628683)1, 9 Yan J....Sommer S.S. (Psychiatr. Genet. 2008)
    7. Analysis of four neuroligin genes as candidates for autism. (PubMed id 16077734)1, 9 Ylisaukko-oja T....JAorvelAo I. (Eur. J. Hum. Genet. 2005)
    8. Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. (PubMed id 18227507)1 Jamain S....Brose N. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. Neuroligins and neurexins link synaptic function to cognitive disease. (PubMed id 18923512)1 SA1dhof T.C. (Nature 2008)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22829 HGNC: 15529 AceView: NLGN4Y Ensembl:ENSG00000165246 euGenes: HUgn22829
    ECgene: NLGN4Y H-InvDB: NLGN4Y

    (According to HUGE)
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    HUGE: KIAA0951

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NLGN4Y Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NLGN4Y gene:
    Search GeneIP for patents involving NLGN4Y

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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