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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NLGN4X Gene

protein-coding   GIFtS: 66
GCID: GC0XM005758

Neuroligin 4, X-Linked

(Previous name: neuroligin 4)
(Previous symbol: NLGN4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuroligin 4, X-Linked1 2     HLNX2
NLGN41 2 3 5     HNL4X2
ASPGX22 5     Neuroligin-4, X-Linked2
AUTSX22 5     HNLX3
KIAA12603 5     Neuroligin X3
Neuroligin 41     

External Ids:    HGNC: 142871   Entrez Gene: 575022   Ensembl: ENSG000001469387   OMIM: 3004275   UniProtKB: Q8N0W43   

Export aliases for NLGN4X gene to outside databases

Previous GC identifers: GC0XM005271 GC0XM005667 GC0XM005818 GC0XM003686


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NLGN4X Gene:
This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a
family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for
beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The
encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with
autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Aug 2013)

GeneCards Summary for NLGN4X Gene: 
NLGN4X (neuroligin 4, X-linked) is a protein-coding gene. Diseases associated with NLGN4X include asperger syndrome susceptibility, x-linked 2, and nlgn4-related x-linked mental retardation, and among its related super-pathways are Synaptic Neurotransmission: GABAergic Inhibition. GO annotations related to this gene include neurexin family protein binding and protein homodimerization activity. An important paralog of this gene is NLGN1.

UniProtKB/Swiss-Prot: NLGNX_HUMAN, Q8N0W4
Function: Putative neuronal cell surface protein involved in cell-cell-interactions

Gene Wiki entry for NLGN4X Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  NC_018934.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NLGN4X
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLGN4X promoter sequence
   Search SABiosciences Chromatin IP Primers for NLGN4X

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLGN4X


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.33   Ensembl cytogenetic band:  Xp22.31   HGNC cytogenetic band: Xp22.33

NLGN4X Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLGN4X gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM005758:  view genomic region     (about GC identifiers)

Start:
5,758,678 bp from pter      End:
6,146,904 bp from pter
Size:
388,227 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NLGNX_HUMAN, Q8N0W4 (See protein sequence)
Recommended Name: Neuroligin-4, X-linked precursor  
Size: 816 amino acids; 91915 Da
Subunit: Homodimer. Interacts with NRXN1 in a calcium-dependent manner. Interacts through its C-terminus with
DLG4/PSD-95 third PDZ domain
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic
cell membrane, postsynaptic density
Sequence caution: Sequence=BAA86574.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for NLGN4X:
2WQZ (3D)        2XB6 (3D)        3BE8 (3D)    
Secondary accessions: Q6UX10 Q9ULG0
Alternative splicing: 2 isoforms:  Q8N0W4-1   Q8N0W4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NLGN4X: NX_Q8N0W4

Explore proteomics data for NLGN4X at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N0W4

  • NLGN4X Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NLGN4X Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001269074.1  NP_001269075.1  NP_065793.1  NP_851849.1  

    ENSEMBL proteins: 
     ENSP00000370485   ENSP00000275857   ENSP00000370482   ENSP00000370483   ENSP00000439203  

    Human Recombinant Protein Products for NLGN4X: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for NLGN4X 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA19726642
    GO:0005887integral to plasma membrane IDA11368788
    GO:0009986cell surface IDA15150161
    GO:0014069postsynaptic density IEA--
    GO:0016021integral to membrane NAS16377159

    NLGN4X for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000460 Neuroligin
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB

    Graphical View of Domain Structure for InterPro Entry Q8N0W4

    ProtoNet protein and cluster: Q8N0W4

    1 Blocks protein domain: IPB000460 Neuroligin signature

    UniProtKB/Swiss-Prot: NLGNX_HUMAN, Q8N0W4
    Similarity: Belongs to the type-B carboxylesterase/lipase family


    NLGN4X for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NLGNX_HUMAN, Q8N0W4
    Function: Putative neuronal cell surface protein involved in cell-cell-interactions

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004091NOT carboxylesterase activity IKR--
    GO:0004872receptor activity IBA--
    GO:0005515protein binding IPI11368788
    GO:0016787hydrolase activity ----
    GO:0031404chloride ion binding IDA18093521
         
    NLGN4X for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NLGN4X:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NLGN4X 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NLGN4X 
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    SwitchGear 3'UTR luciferase reporter plasmidNLGN4X 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NLGN4X About                                                                                                See pathways by source

    SuperPathContained pathways About
    1GABA A receptor activation
    GABA signaling in brain0.32
    2Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NLGN4X
        GABA signaling in brain




    1         Kegg Pathway  (Kegg details for NLGN4X):
        Cell adhesion molecules (CAMs)


    NLGN4X for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NLGN4X

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for NLGN4X (Q8N0W42, 3 ENSP000002758574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLGAP2Q9P1A63, ENSP000004002584I2D: score=1 STRING: ENSP00000400258
    DLG4P783523I2D: score=2 
    --ENSP000002938134STRING: ENSP00000293813
    --Q633732MINT-7988481 MINT-7988502 MINT-7988463 MINT-7988518 MINT-7988534
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003360brainstem development ISS18227507
    GO:0007155cell adhesion IEA--
    GO:0008152metabolic process ----
    GO:0021549cerebellum development ISS18227507
    GO:0035176social behavior IMP12669065

    NLGN4X for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NLGN4X (NLGNX)

    Search CenterWatch for drugs/clinical trials and news about NLGN4X / NLGNX

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NLGN4X gene (4 alternative transcripts): 
    NM_001282145.1  NM_001282146.1  NM_020742.3  NM_181332.2  

    Unigene Cluster for NLGN4X:

    Neuroligin 4, X-linked
    Hs.21107  [show with all ESTs]
    Unigene Representative Sequence: NM_020742
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477079 ENST00000381095(uc010ndh.3 uc004crr.3 uc010ndj.3)
    ENST00000275857 ENST00000381092 ENST00000469740 ENST00000483337 ENST00000381093(uc004crp.3 uc004crq.3 uc010ndi.3)
    ENST00000538097
    miRNA
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    hsa-miR-323-3p hsa-miR-607 hsa-miR-376b hsa-miR-3653 hsa-miR-155* hsa-miR-200b hsa-miR-4293 hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidNLGN4X 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB033086.1 AF376803.1 AK022621.1 AK055471.1 AK125309.1 AK291036.1 AY358562.1 BC034018.1 

    10 DOTS entries:

    DT.100021786  DT.311331  DT.100779334  DT.40230062  DT.121320862  DT.97838788  DT.95224348  DT.121320853 
    DT.40218658  DT.95078344 

    7 AceView cDNA sequences:

    BX642507 AA322866 BP361697 BU845399 BQ951136 BG547451 BI458949 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NLGN4X (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10
    SP1:                                                                                                                        
    SP2:              -     -     -     -     -     -                                                                           
    SP3:              -     -     -     -     -     -     -                                                                     
    SP4:                    -     -     -     -     -     -                                                                     
    SP5:                          -     -     -     -     -                                                                     


    ECgene alternative splicing isoforms for NLGN4X

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NLGN4X expression in normal human tissues (normalized intensities)      NLGN4X embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACACAAA
    NLGN4X Expression
    About this image


    NLGN4X expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 9 entries
             Line H9 (WA09)
             ESI-049   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Human Cerebellar Astrocytes   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human corneal endothelial cells
             Human Lens Epithelial Cells (HLEpiC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human corneal endothelial cells
             Endothelial progenitor cells ( Derivation and purification of endothelial precursor...
     
     Thymus (Hematopoietic System)
             Double Negative 3 Thymocytes Thymus

    See NLGN4X Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NLGN4X

    SOURCE GeneReport for Unigene cluster: Hs.21107

    UniProtKB/Swiss-Prot: NLGNX_HUMAN, Q8N0W4
    Tissue specificity: Expressed at highest levels in heart. Expressed at lower levels in liver, skeletal muscle and
    pancreas and at very low levels in brain

        SABiosciences Custom PCR Arrays for NLGN4X
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLGN4X

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NLGN4X gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia NLGN4X1 neuroligin 4, X-linked 89.13(n)
    98.77(a)
      607406  XM_850790.2  XP_855883.2 
    chicken
    (Gallus gallus)
    Aves NLGN4X1 neuroligin 4, X-linked 81.25(n)
    95.96(a)
      428006  NM_001171770.1  NP_001165241.1 
    lizard
    (Anolis carolinensis)
    Reptilia NLGN46
    Neuroligin 4
    93(a)
    1 → many
    3(116267805-116540581)
    zebrafish
    (Danio rerio)
    Actinopterygii 570960972   -- 74.69(n)    57096097 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG341276
    CG341396
    (see all 3)
    --
    22(a)
    21(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3R(3396003-3465156)
    3R(16030531-16071195)


    ENSEMBL Gene Tree for NLGN4X (if available)
    TreeFam Gene Tree for NLGN4X (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NLGN4X gene
    NLGN12  CES22  ACHE2  CES4A2  NLGN4Y2  CES32  NLGN32  NLGN22  
    CES12  CEL2  CES5A2  BCHE2  
    9 SIMAP similar genes for NLGN4X using alignment to 1 protein entry:     NLGNX_HUMAN:
    NLGN4Y    NLGN3    DKFZp686F02202    nlgn1    NLGN1    NLGN2
    CES2    BCHE    ACHE

    NLGN4X for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5609 SNPs in NLGN4X are shown (see all 5609)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365764
    A colorectal cancer sample4--see VAR_0365762 G S mis40--------
    rs1881824971,2
    --5807603(+) TGTCAA/GATAAG 2 -- ds50010--------
    rs1915017481,2
    --5807753(+) GTGTTC/TTGTTG 2 -- ds50010--------
    rs59156181,2
    C,F,H--5807768(+) CAAATC/AAAAAC 2 -- ds500114Minor allele frequency- A:0.12NS EA NA 1965
    rs1854114261,2
    --5807920(+) CAAAGA/CTAAAG 2 -- ds50010--------
    rs1906150141,2
    --5807974(+) GTCAGA/GCGCAT 2 -- ds50010--------
    rs1822874301,2
    --5808082(+) AAAGCA/GTTAGA 2 -- ds50010--------
    rs2015654091,2
    --5808302(+) TTTTT-/TCTTTTT 2 -- ut310--------
    rs1868944751,2
    --5808355(+) CTCTAG/TGAAGA 2 -- ut310--------
    rs1455352491,2
    C--5808461(+) CTTAAC/TAGGAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NLGN4X (5758678 - 6008678 bp, first 250kb of NLGN4X)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for NLGN4X (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1398053CNV Deletion17803354
    esv2662877CNV Deletion23128226
    nsv507943CNV Insertion20534489
    nsv510523CNV Loss20534489
    nsv520621CNV Gain19592680
    esv988822CNV Gain20482838
    nsv522938CNV Gain19592680
    nsv528749CNV Gain19592680
    nsv526949CNV Gain19592680
    esv33664CNV Gain+Loss17666407


    Human Gene Mutation Database (HGMD): NLGN4X

    Locus Specific Mutation Databases (LSDB): NLGN4X
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NLGN4X
    DNA2.0 Custom Variant and Variant Library Synthesis for NLGN4X

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300427   
    OMIM disorders: 300495  300497  
    UniProtKB/Swiss-Prot: NLGNX_HUMAN, Q8N0W4
  • Autism, X-linked 2 (AUTSX2) [MIM:300495]: A complex multifactorial, pervasive developmental disorder
    characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped
    patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most
    individuals with autism also manifest moderate mental retardation. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry
  • Asperger syndrome, X-linked, 2 (ASPGX2) [MIM:300497]: A syndrome with features similar to autism.
    Affected individuals exhibit qualitative impairment in social interaction, as manifest by impairment in the use
    of non-verbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures, failure to
    develop appropriate peer relationships, and lack of social sharing or reciprocity. Patients also exhibit
    restricted, repetitive and stereotyped patterns of behavior, interests, and activities, including abnormal
    preoccupation with certain activities and inflexible adherence to routines or rituals. Asperger syndrome is
    primarily distinguished from autism by the higher cognitive abilities and a more normal and timely development of
    language and communicative phrases. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • 20 diseases for NLGN4X:    About MalaCards
    asperger syndrome susceptibility, x-linked 2    nlgn4-related x-linked mental retardation    autism susceptibility, x-linked 2    autistic disorder
    asperger syndrome    pervasive developmental disorder    autism spectrum disorder    atypical autism
    x-linked ichthyosis    ocular albinism    kallmann syndrome    ichthyosis
    albinism    attention deficit hyperactivity disorder    mental retardation, x-linked    intellectual disability
    mental retardation    schizophrenia    tuberculosis    neuronitis

    6 diseases from the University of Copenhagen DISEASES database for NLGN4X:
    Asperger syndrome     Autistic disorder     Atypical autism     Intellectual disability
    X-linked ichthyosis     Kallmann syndrome

    NLGN4X for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for NLGN4X gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autistic 76 14 16648374 (4), 18189281 (2), 19645625 (1), 14963808 (1) (see all 8)
    mental retardation 60.4 12 14963808 (3), 19545860 (2), 16470742 (1), 18628683 (1) (see all 7)
    pervasive developmental disorder 59.1 1 14963808 (1)

    GeneTests: NLGN4X
    GeneReviews: NLGN4X
    Genetic Association Database (GAD): NLGN4X
    Human Genome Epidemiology (HuGE) Navigator: NLGN4X (11 documents)

    Export disorders for NLGN4X gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NLGN4X gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with NLGN4X)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. A substitution involving the NLGN4 gene associated wi th autistic behavior in the Greek population. (PubMed id 19645625)1, 4, 9 Pampanos A....Kitsiou-Tzeli S. (2009)
    3. X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family. (PubMed id 14963808)1, 2, 9 Laumonnier F.... Briault S. (2004)
    4. Positive association of neuroligin-4 gene with nonspecific mental retardation in the Qinba Mountains Region of China. (PubMed id 19125102)1, 4, 9 Qi H....Zhang F. (2009)
    5. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. (PubMed id 12669065)1, 2, 9 Jamain S.... Van Maldergem L. (2003)
    6. Analysis of the neuroligin 4Y gene in patients with autism. (PubMed id 18628683)1, 4, 9 Yan J....Sommer S.S. (2008)
    7. Polymorphisms of candidate genes in Slovak autistic p atients. (PubMed id 20436377)1, 4 Kelemenova S....Ostatnikova D. (2010)
    8. Genes related to sex steroids, neural growth, and soc ial-emotional behavior are associated with autistic traits, empathy, and Asperg er syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (2009)
    9. Recurrent rearrangements in synaptic and neurodevelop mental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. (PubMed id 19736351)1, 4 Guilmatre A....Campion D. (2009)
    10. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57502 HGNC: 14287 AceView: NLGN4X.1 Ensembl:ENSG00000146938 euGenes: HUgn57502
    ECgene: NLGN4X Kegg: 57502 H-InvDB: NLGN4X

    (According to HUGE)
    About This Section
    HUGE: KIAA1260

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NLGN4X Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NLGN4X

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NLGN4X gene:
    Search GeneIP for patents involving NLGN4X

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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