NLGN4X Gene

Aliases
for NLGN4X gene

Previous GC identifers: GC0XM005271 GC0XM005667 GC0XM005818 GC0XM003686

Summaries
for NLGN4X gene

Genomic Views
for NLGN4X gene

RefSeq DNA sequence:

NC_000023.10  NC_018934.1  NT_167197.1  

SwitchGear Promoter luciferase reporter plasmid: NLGN4X promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLGN4X

NLGN4X Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM005758:  view genomic region     (about GC identifiers)

Proteins
for NLGN4X gene

3 PDB 3D structures from and Proteopedia for NLGN4X:

2WQZ (3D)        2XB6 (3D)        3BE8 (3D)    

Explore the universe of human proteins at neXtProt for NLGN4X: NX_Q8N0W4

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for NLGN4X (Neuroligin 4/NLGN4)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): NLGN4X OriGene Protein Over-expression Lysate (see all 2): NLGN4X OriGene Custom Protein Services for NLGN4X
	GenScript Custom Purified and Recombinant Proteins Services for NLGN4X
	Novus Biologicals NLGN4X Protein Novus Biologicals NLGN4X Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NLGN4X

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for NLGN4X (Neuroligin 4/NLGN4)
	Browse OriGene Antibodies OriGene Custom Antibody Services for NLGN4X
	GenScript Custom Superior Antibodies Services for NLGN4X
	Novus Biologicals NLGN4X Antibodies
	Search for Antibodies for NLGN4X at Abcam
	Uscn Antibodies for NLGN4X
	Search ThermoFisher Antibodies for NLGN4X

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NLGN4X
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NLGN4X

Protein Domains /
Families
for NLGN4X gene

ProtoNet protein and cluster: Q8N0W4

Function
for NLGN4X gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): NLGN4X Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NLGN4X
		8/66 QIAGEN miScript miRNA Assays for microRNAs that regulate NLGN4X (see all 66):
		hsa-miR-323-3p hsa-miR-607 hsa-miR-376b hsa-miR-3653 hsa-miR-155* hsa-miR-200b hsa-miR-4293 hsa-miR-130a*
		SwitchGear 3'UTR luciferase reporter plasmid: NLGN4X 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NLGN4X OriGene shRNA RFP: NLGN4X OriGene siRNA: NLGN4X
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NLGN4X

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for NLGN4X

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN4X (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN4X (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): NLGN4X (NM_020742)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NLGN4X
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLGN4X

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NLGN4X
		Search LifeMap BioReagents cell lines for NLGN4X

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLGN4X

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

Pathways & Interactions
for NLGN4X gene

	Super-pathway	contained gene-specific pathways
1	Cell adhesion molecules (CAMs)	Cell adhesion molecules (CAMs) 1.00
2	GABA A receptor activation	GABA signaling in brain 0.26

1 EMD Millipore Pathway for NLGN4X

GABA signaling in brain

1         Kegg Pathway  (Kegg details for NLGN4X)

Cell adhesion molecules (CAMs)

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

Drugs & Compounds
for NLGN4X gene

Transcripts
for NLGN4X gene

Expression
for NLGN4X gene

NLGN4X expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACACACAAA

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLGN4X Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NLGN4X
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLGN4X
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLGN4X

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLGN4X

Orthologs
for NLGN4X gene

Paralogs
for NLGN4X gene

Paralogs for NLGN4X gene

NLGN1²  CES2²  ACHE²  CES4A²  NLGN4Y²  CES3²  NLGN3²  NLGN2²  

CES1²  CEL²  BCHE²  CES5A²  

9 SIMAP similar genes for NLGN4X using alignment to 1 protein entry:     NLGNX_HUMAN:

NLGN4Y    NLGN3    DKFZp686F02202    nlgn1    NLGN1    NLGN2

CES2    BCHE    ACHE

NLGN4X for paralogs           About GeneDecksing

Genomic Variants
for NLGN4X gene

10/4805 NCBI SNPs in NLGN4X are shown (see all 4805)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1881824971,2		--	5807603(+)	TGTCAA/GATAAG	2	--	ds5001		0	--	--	--	--
rs1915017481,2		--	5807753(+)	GTGTTC/TTGTTG	2	--	ds5001		0	--	--	--	--
rs59156181,2	C,F,H,	--	5807768(+)	CAAATC/AAAAAC	2	--	ds5001		14		NS EA NA	1965
rs1854114261,2		--	5807920(+)	CAAAGA/CTAAAG	2	--	ds5001		0	--	--	--	--
rs1906150141,2		--	5807974(+)	GTCAGA/GCGCAT	2	--	ds5001		0	--	--	--	--
rs1822874301,2		--	5808082(+)	AAAGCA/GTTAGA	2	--	ds5001		0	--	--	--	--
rs2015654091,2		--	5808302(+)	TTTTT-/TCTTTTT	2	--	ut31		0	--	--	--	--
rs1868944751,2		--	5808355(+)	CTCTAG/TGAAGA	2	--	ut31		0	--	--	--	--
rs1455352491,2		--	5808461(+)	CTTAAC/TAGGAA	2	--	ut31		0	--	--	--	--
rs1381605191,2		--	5808503(+)	CTGACA/GCGTTA	2	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for NLGN4X (5758678 - 6008678 bp, first 250kb of NLGN4X)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for NLGN4X
     7 CNVs: 7794 96440 96438 83305 96437 39570 83304
     1 Indel: 96439
     1 Inversion: 59877
Human Gene Mutation Database (HGMD): NLGN4X

Locus Specific Mutation Databases (LSDB): NLGN4X

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLGN4X

DNA2.0 Custom Variant and Variant Library Synthesis for NLGN4X

Disorders / Diseases
for NLGN4X gene

20 diseases for NLGN4X

3 Novoseek disease relationships for NLGN4X gene    About this table

Publications
for NLGN4X gene

PubMed articles for NLGN4X gene, integrated from 9 sources (see all 48): (articles sorted by number of sources associating them with NLGN4X)

Utopia: connect your pdf to the dynamic world of online information

1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2, 3} Nagase T.... Ohara O. (1999)
2. X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family. (PubMed id 14963808)^{1, 2, 9} Laumonnier F.... Briault S. (2004)
3. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. (PubMed id 12669065)^{1, 2, 9} Jamain S.... Van Maldergem L. (2003)
4. Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion. (PubMed id 18093521)^{1, 2} Fabrichny I.P....Marchot P. (2007)
5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
8. Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression. (PubMed id 11368788)^{1, 2} Bolliger M.F.... Gloor S.M. (2001)
9. Binding of neuroligins to PSD-95. (PubMed id 9278515)^{1, 2} Irie M.... Suedhof T.C. (1997)
10. Autism and nonsyndromic mental retardation associated with a de novo mutation in the NLGN4X gene promoter causing an increased expre ssion level. (PubMed id 19545860)^{1, 9} Daoud H....Briault S. (2009)

External Searches for NLGN4X gene

Genome Databases showing NLGN4X gene

Other Databases showing NLGN4X gene

Specialized Databases showing NLGN4X gene

Products
for NLGN4X gene