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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NLGN3 Gene

protein-coding   GIFtS: 65
GCID: GC0XP070364

Neuroligin 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuroligin 31 2     KIAA14803
Gliotactin Homolog2 3     NL33
HNL32     ASPGX15
neuroligin-32     AUTSX15

External Ids:    HGNC: 142891   Entrez Gene: 544132   Ensembl: ENSG000001963387   OMIM: 3003365   UniProtKB: Q9NZ943   

Export aliases for NLGN3 gene to outside databases

Previous GC identifers: GC0XP066538 GC0XP067842 GC0XP068597 GC0XP069231 GC0XP070147 GC0XP070281 GC0XP064183


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NLGN3 Gene:
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice
site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous
system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript
variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Oct 2009)

GeneCards Summary for NLGN3 Gene: 
NLGN3 (neuroligin 3) is a protein-coding gene. Diseases associated with NLGN3 include autistic disorder, and autism susceptibility, x-linked 1, and among its related super-pathways are Synaptic Neurotransmission: GABAergic Inhibition. GO annotations related to this gene include neurexin family protein binding and receptor activity. An important paralog of this gene is NLGN1.

UniProtKB/Swiss-Prot: NLGN3_HUMAN, Q9NZ94
Function: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family
members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by
clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this.
May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By
similarity)

Gene Wiki entry for NLGN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011669.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NLGN3 gene promoter:
         E2F-3a   E2F-4   E2F-5   p300   E2F-2   E2F-1   E2F   HOXA5   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLGN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NLGN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLGN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

NLGN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLGN3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP070364:  view genomic region     (about GC identifiers)

Start:
70,364,681 bp from pter      End:
70,391,051 bp from pter
Size:
26,371 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NLGN3_HUMAN, Q9NZ94 (See protein sequence)
Recommended Name: Neuroligin-3 precursor  
Size: 848 amino acids; 93895 Da
Subunit: Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3)
(By similarity). Homodimer, and heterodimer with NLGN1 and NLGN2 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse
(By similarity). Note=Detected at both glutamatergic and GABAergic synapses (By similarity)
Sequence caution: Sequence=AAF71231.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA96004.1; Type=Erroneous initiation; Sequence=BAC11226.1; Type=Erroneous initiation;
Secondary accessions: B2RBK1 D2X2H6 D3DVV0 Q86V51 Q8NCD0 Q9NZ95 Q9NZ96 Q9NZ97 Q9P248
Alternative splicing: 2 isoforms:  Q9NZ94-1   Q9NZ94-2   

Explore the universe of human proteins at neXtProt for NLGN3: NX_Q9NZ94

Explore proteomics data for NLGN3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZ94

  • NLGN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NLGN3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001160132.1  NP_061850.2  NP_851820.1  

    ENSEMBL proteins: 
     ENSP00000379196   ENSP00000363163   ENSP00000351591   ENSP00000445298  

    Human Recombinant Protein Products for NLGN3: 
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    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005887integral to plasma membrane ISS--
    GO:0009986cell surface IDA15150161
    GO:0016020membrane ----
    GO:0030054cell junction IEA--

    NLGN3 for ontologies           About GeneDecksing



    NLGN3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000460 Neuroligin
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB

    Graphical View of Domain Structure for InterPro Entry Q9NZ94

    ProtoNet protein and cluster: Q9NZ94

    1 Blocks protein domain: IPB000460 Neuroligin signature

    UniProtKB/Swiss-Prot: NLGN3_HUMAN, Q9NZ94
    Similarity: Belongs to the type-B carboxylesterase/lipase family


    NLGN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NLGN3_HUMAN, Q9NZ94
    Function: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family
    members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by
    clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this.
    May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By
    similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004091NOT carboxylesterase activity IKR--
    GO:0004872receptor activity ISS--
    GO:0005515protein binding IPI17292328
    GO:0016787hydrolase activity ----
    GO:0042043neurexin family protein binding ISS15152050
         
    NLGN3 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Nlgn3):
     behavior/neurological  growth/size  mortality/aging  nervous system  no phenotypic analysis 
     normal  reproductive system  respiratory system  taste/olfaction 

    NLGN3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NLGN3: Nlgn3tm2.1Sud Nlgn3tm1Rhn Nlgn3tm1Bros

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NLGN3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NLGN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NLGN3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NLGN3 

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    SwitchGear 3'UTR luciferase reporter plasmidNLGN3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLGN3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NLGN3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1GABA A receptor activation
    GABA signaling in brain0.32
    2Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NLGN3
        GABA signaling in brain




    1         Kegg Pathway  (Kegg details for NLGN3):
        Cell adhesion molecules (CAMs)


    NLGN3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NLGN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/11 Interacting proteins for NLGN3 (Q9NZ943 ENSP000003631634) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRXN1P584003, ENSP000003851424I2D: score=2 I2D: score=1 STRING: ENSP00000385142
    NRXN2P584013, ENSP000002654594I2D: score=1 I2D: score=1 STRING: ENSP00000265459
    NRXN3Q9Y4C03, ENSP000003383494I2D: score=3 STRING: ENSP00000338349
    DLG2Q157003, ENSP000003652724I2D: score=2 STRING: ENSP00000365272
    DLG3Q927963, ENSP000003634804I2D: score=2 STRING: ENSP00000363480
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002087regulation of respiratory gaseous exchange by neurological system process IEA--
    GO:0006898receptor-mediated endocytosis ISS--
    GO:0007155cell adhesion ----
    GO:0007158neuron cell-cell adhesion ISS--
    GO:0007416synapse assembly ISS--

    NLGN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NLGN3

    Search CenterWatch for drugs/clinical trials and news about NLGN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for NLGN3 gene (3 alternative transcripts): 
    NM_001166660.1  NM_018977.3  NM_181303.1  

    Unigene Cluster for NLGN3:

    Neuroligin 3
    Hs.438877  [show with all ESTs]
    Unigene Representative Sequence: NM_181303
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395855(uc011mpr.1) ENST00000374051(uc004dzd.2 uc004dzb.3 uc004dzc.3)
    ENST00000358741 ENST00000476589(uc004dze.3) ENST00000536169(uc011mps.2)

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    SwitchGear 3'UTR luciferase reporter plasmidNLGN3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB040913.1 AF217411.1 AF217412.1 AK074814.1 AK296217.1 AK299567.1 AK299669.1 AK314699.1 
    BC028738.1 BC051715.1 BX641059.1 GQ489207.1 

    5 DOTS entries:

    DT.406638  DT.91912598  DT.91727662  DT.91757103  DT.100020204 

    24/64 AceView cDNA sequences (see all 64):

    AX773949 AB040913 AF217411 BF594214 AX773948 CB153744 AL120471 AL120470 
    AI142535 NM_018977 AF217412 CB106668 AW296639 BC028738 BI032719 BI549518 
    AJ252067 BF591539 BI603914 AA057440 BI602237 AI159884 BI597956 BX641059 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NLGN3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                    -     -           -                             -     -                     
    SP2:                                      -                             -     -                     
    SP3:                                                                    -     -                     
    SP4:                                      -     -                       -     -                     
    SP5:                                                                                                


    ECgene alternative splicing isoforms for NLGN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NLGN3 expression in normal human tissues (normalized intensities)      NLGN3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTTTGTCC
    NLGN3 Expression
    About this image


    NLGN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Septum   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Colon (Gastrointestinal Tract)
             rectum ; glandular cells   
     
     Oral Cavity (Gastrointestinal Tract)
             oral mucosa ; squamous epithelial cells   
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium

    See NLGN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NLGN3

    SOURCE GeneReport for Unigene cluster: Hs.438877

    UniProtKB/Swiss-Prot: NLGN3_HUMAN, Q9NZ94
    Tissue specificity: Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and
    in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLGN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NLGN3 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nlgn31 , 5 neuroligin 31, 5 93.29(n)1
    99.03(a)1
      X (43.95 cM)5
    2455371  NM_172932.41  NP_766520.21 
     1012991685 
    chicken
    (Gallus gallus)
    Aves NLGN31 neuroligin 3 82.19(n)
    90.93(a)
      770104  NM_001173521.1  NP_001166992.1 
    lizard
    (Anolis carolinensis)
    Reptilia NLGN36
    neuroligin 3
    88(a)
    1 ↔ 1
    GL343599.1(236274-276423)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.87722 Xenopus laevis transcribed sequence with moderate similarity more 77.07(n)    AW159452.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nlgn3a1 neuroligin 3a 74.59(n)
    84.53(a)
      562702  NM_001166332.1  NP_001159804.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50303
    CG341271
    NOT carboxylesterase3
    CG341271
    41(a)
    (best of 16)3
    46.81(n)1
    37.67(a)1
      92D63
    409121  NM_001043220.21  NP_001036685.21 


    ENSEMBL Gene Tree for NLGN3 (if available)
    TreeFam Gene Tree for NLGN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NLGN3 gene
    NLGN12  CES22  ACHE2  CES4A2  NLGN4X2  NLGN4Y2  CES32  NLGN22  
    CES12  CEL2  CES5A2  BCHE2  
    16 SIMAP similar genes for NLGN3 using alignment to 4 protein entries:     NLGN3_HUMAN (see all proteins):
    DKFZp686F02202    NLGN4X    NLGN2    nlgn1    NLGN4Y    NLGN1
    CES1P1    TG    CES3    CES2    BCHE    ACHE
    CES4A    CES8    CES1    CES hBr2

    NLGN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/441 SNPs in NLGN3 are shown (see all 441)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0156684
    Autism, X-linked 1 (AUTSX1)4--see VAR_0156682 R C mis40--------
    rs1219178931,2
    Cother170395294(+) CCCGCC/TGTAAA 6 R C mis10--------
    rs1120798361,2
    C--70364988(+) TCCCT-/TCTACC 3 -- int11Minor allele frequency- T:0.00CSA 2
    rs2012139761,2
    --70370839(+) TCCTG-/GGTTCAAG 3 -- us2k10--------
    rs1996692891,2
    --70370840(+) CCTGG-/GTTCAAGT 3 -- us2k10--------
    rs1913161891,2
    --70370849(+) AAGTGA/CTTATC 3 -- us2k10--------
    rs582139671,2
    --70370888(+) ATTACA/CGGCAT 3 -- us2k10--------
    rs600907561,2
    C--70371039(+) ACCACG/ACCCGT 3 -- us2k12Minor allele frequency- A:0.25WA 4
    rs1379491671,2
    C--70371064(+) AAGAAA/GGGGCA 3 -- us2k10--------
    rs1858019851,2
    --70371131(+) ATACCA/GCTGGG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for NLGN3 (70364681 - 70391051 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NLGN3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33082CNV Loss17666407
    esv27208CNV Gain19812545
    esv1584074OTHER Inversion17803354


    Human Gene Mutation Database (HGMD): NLGN3

    Locus Specific Mutation Databases (LSDB): NLGN3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NLGN3
    DNA2.0 Custom Variant and Variant Library Synthesis for NLGN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300336   
    OMIM disorders: 300425  300494  
    UniProtKB/Swiss-Prot: NLGN3_HUMAN, Q9NZ94
  • Autism, X-linked 1 (AUTSX1) [MIM:300425]: A complex multifactorial, pervasive developmental disorder
    characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped
    patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most
    individuals with autism also manifest moderate mental retardation. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry
  • Asperger syndrome, X-linked, 1 (ASPGX1) [MIM:300494]: A syndrome with features similar to autism.
    Affected individuals exhibit qualitative impairment in social interaction, as manifest by impairment in the use
    of non-verbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures, failure to
    develop appropriate peer relationships, and lack of social sharing or reciprocity. Patients also exhibit
    restricted, repetitive and stereotyped patterns of behavior, interests, and activities, including abnormal
    preoccupation with certain activities and inflexible adherence to routines or rituals. Asperger syndrome is
    primarily distinguished from autism by the higher cognitive abilities and a more normal and timely development of
    language and communicative phrases. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • 12 diseases for NLGN3:    About MalaCards
    autistic disorder    autism susceptibility, x-linked 1    asperger syndrome susceptibility, x-linked 1    asperger syndrome
    atypical autism    autism spectrum disorder    pervasive developmental disorder    intellectual disability
    mental retardation    neuronitis    tuberculosis    pancreatitis

    3 diseases from the University of Copenhagen DISEASES database for NLGN3:
    Autistic disorder     Asperger syndrome     Atypical autism

    NLGN3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for NLGN3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autistic 73.2 13 16648374 (3), 18189281 (2), 15152050 (1), 15389766 (1) (see all 7)
    mental retardation 30.9 3 18628683 (1), 16118346 (1)

    GeneTests: NLGN3
    GeneReviews: NLGN3
    Genetic Association Database (GAD): NLGN3
    Human Genome Epidemiology (HuGE) Navigator: NLGN3 (6 documents)

    Export disorders for NLGN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NLGN3 gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with NLGN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The structure and expression of the human neuroligin-3 gene. (PubMed id 10767552)1, 2, 3 Philibert R.A.... Ginns E.I. (2000)
    2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. A substitution involving the NLGN4 gene associated wi th autistic behavior in the Greek population. (PubMed id 19645625)1, 4, 9 Pampanos A....Kitsiou-Tzeli S. (2009)
    4. Analysis of the neuroligin 4Y gene in patients with autism. (PubMed id 18628683)1, 4, 9 Yan J....Sommer S.S. (2008)
    5. NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population. (PubMed id 15389766)1, 4, 9 Gauthier J....Rouleau G.A. (2005)
    6. Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands. (PubMed id 15274046)1, 4, 9 Vincent J.B....Scherer S.W. (2004)
    7. Characterization of the neuroligin gene family expression and evolution in zebrafish. (PubMed id 20034102)1, 2 Rissone A.... Cotelli F. (2010)
    8. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    9. Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. (PubMed id 15620359)1, 2 Graf E.R....Craig A.M. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54413 HGNC: 14289 AceView: NLGN3 Ensembl:ENSG00000196338 euGenes: HUgn54413
    ECgene: NLGN3 Kegg: 54413 H-InvDB: NLGN3

    (According to HUGE)
    About This Section
    HUGE: KIAA1480

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NLGN3 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NLGN3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NLGN3 gene:
    Search GeneIP for patents involving NLGN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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