External Ids for NLGN3 Gene
Previous GeneCards Identifiers for NLGN3 Gene
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for NLGN3 Gene
NLGN3 (Neuroligin 3) is a Protein Coding gene. Diseases associated with NLGN3 include autism susceptibility, x-linked 1 and asperger syndrome susceptibility, x-linked 1. Among its related pathways are Cell adhesion molecules (CAMs). GO annotations related to this gene include hydrolase activity and cell adhesion molecule binding. An important paralog of this gene is CES2.
UniProtKB/Swiss-Prot for NLGN3 Gene
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity).