NLGN3 Gene
protein-coding GIFtS: 64
GCID: GC0XP070364
|
|
neuroligin 3
| |
Aliases
for NLGN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neuroligin 31 2 | | ASPGX11 5 | | HNL31 2 | | AUTSX11 5 | | KIAA14801 3 | | Neuroligin-31 | | Gliotactin Homolog2 3 | | NL33 |
Export aliases for NLGN3 gene to outside databasesPrevious GC identifers: GC0XP066538 GC0XP067842 GC0XP068597 GC0XP069231 GC0XP070147 GC0XP070281 GC0XP064183 |
Summaries
for NLGN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NLGN3:
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splicesite-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous systemsynapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variantsencoding distinct isoforms have been identified for this gene. (provided by RefSeq, Oct 2009)
UniProtKB/Swiss-Prot: NLGN3_HUMAN, Q9NZ94Function: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members.Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering othersynaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a rolein glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity)
Gene Wiki entry for NLGN3
|
Genomic Views
for NLGN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NLGN3 gene promoter:
E2F-3a E2F-4 E2F-5 p300 E2F-2 E2F-1 E2F HOXA5 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NLGN3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLGN3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.1 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1NLGN3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP070364: view genomic region
(about GC identifiers)
Start:
|
70,364,681 bp from pter |
End:
|
70,391,051 bp from pter |
Size:
|
26,371 bases |
Orientation:
|
plus strand |
|
Proteins
for NLGN3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NLGN3_HUMAN, Q9NZ94 (See
protein sequence)Recommended Name: Neuroligin-3 precursor Size: 848 amino acids; 93895 Da
Subunit: Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) (Bysimilarity). Homodimer, and heterodimer with NLGN1 and NLGN2 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse (Bysimilarity). Note=Detected at both glutamatergic and GABAergic synapses (By similarity)
Sequence caution: Sequence=AAF71231.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=BAA96004.1; Type=Erroneous initiation; Sequence=BAC11226.1; Type=Erroneous initiation;
Secondary accessions: B2RBK1 D2X2H6 D3DVV0 Q86V51 Q8NCD0 Q9NZ95 Q9NZ96 Q9NZ97 Q9P248Alternative splicing: 2 isoforms: Q9NZ94-1 Q9NZ94-2 Explore the universe of human proteins at neXtProt for NLGN3: NX_Q9NZ94
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NZ94
NLGN3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001160132.1 NP_061850.2 NP_851820.1
ENSEMBL proteins: ENSP00000363163 ENSP00000379196 ENSP00000351591 ENSP00000445298
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
NLGN3 for ontologies About GeneDecksing
NLGN3 Antibody Products:
Assay Products for NLGN3: |
Protein
Domains /
Families
for NLGN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NLGN3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NZ94ProtoNet protein and cluster: Q9NZ94 1 Blocks protein family: IPB000460 Neuroligin signature
UniProtKB/Swiss-Prot: NLGN3_HUMAN, Q9NZ94Similarity: Belongs to the type-B carboxylesterase/lipase family |
Function
for NLGN3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NLGN3_HUMAN, Q9NZ94Function: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members.Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering othersynaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a rolein glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLGN3 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
NLGN3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for NLGN3: Nlgn3tm2.1Sud Nlgn3tm1Rhn Nlgn3tm1Bros
9 MGI mutant phenotypes (inferred from 8 alleles ) (MGI details for Nlgn3):
NLGN3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NLGN3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell adhesion molecules (CAMs) | | | 2 | GABA A receptor activation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for NLGN3
1 
Kegg Pathway (Kegg details for NLGN3):
NLGN3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NLGN3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/10 Interacting proteins for NLGN3 (Q9NZ943 ENSP000003631634) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002087 | regulation of respiratory gaseous exchange by neurological system process |
IEA | -- | | GO:0006898 | receptor-mediated endocytosis |
ISS | -- | | GO:0007155 | cell adhesion |
-- | -- | | GO:0007158 | neuron cell-cell adhesion |
ISS | -- | | GO:0007416 | synapse assembly |
ISS | -- |
NLGN3 for ontologies About GeneDecksing
|
Drugs & Compounds
for NLGN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NLGN3
Search CenterWatch for drugs/clinical trials and news about NLGN3
|
Transcripts
for NLGN3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NLGN3 gene (3 alternative transcripts): NM_001166660.1 NM_018977.3 NM_181303.1 Unigene Cluster for NLGN3: Neuroligin 3 Hs.438877 [show with all ESTs]Unigene Representative Sequence: NM_1813035 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374051(uc004dzd.2 uc004dzb.3 uc004dzc.3) ENST00000395855(uc011mpr.1)
ENST00000358741 ENST00000476589(uc004dze.3) ENST00000536169(uc011mps.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): NLGN3 (NM_018977) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NLGN3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLGN3 |
Additional cDNA sequence: AB040913.1 AF217411.1 AF217412.1 AK074814.1 AK296217.1 AK299567.1 AK299669.1 AK314699.1 BC028738.1 BC051715.1 BX641059.1 GQ489207.1 5 DOTS entries: DT.406638 DT.91912598 DT.91727662 DT.91757103 DT.100020204 24/64 AceView cDNA sequences (see all 64): NM_018977 AB040913 AI142535 CB106668 AX773949 AX773948 AL120471 CB153744 BF594214 AL120470 AF217411 AF217412 BC028738 AW296639 BX091876 AK074814 BG820379 CB216335 AA057440 AJ252067 AI159884 BF530894 AI831875 AI376795
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NLGN3 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 |
|---|
|
| SP1: | | | | | | | - | | - | | | | - | | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | | | | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NLGN3
|
Expression
for NLGN3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NLGN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTTTGTCC
About this image
See NLGN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NLGN3
SOURCE GeneReport for Unigene cluster: Hs.438877
UniProtKB/Swiss-Prot: NLGN3_HUMAN, Q9NZ94Tissue specificity: Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and inspinal cord. Detected in brain, and at lower levels in pancreas islet beta cells
SABiosciences Custom PCR Arrays for NLGN3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLGN3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NLGN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLGN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLGN3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLGN3 |
Orthologs
for NLGN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NLGN3 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NLGN31 |
neuroligin 3 |
82.19(n)
90.93(a) |
|
770104 NM_001173521.1 NP_001166992.1 |
lizard
(Anolis carolinensis) |
Reptilia |
D2X2H9_ANOCA6 |
Neuroligin 3 |
89(a) |
1 ↔ 1 |
GL343599.1(238511-259520) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.87722 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.07(n) |
|
AW159452.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
nlgn3a1 |
neuroligin 3a |
74.59(n)
84.53(a) |
|
562702 NM_001166332.1 NP_001159804.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG50303
CG341271 |
NOT carboxylesterase3
CG341271 |
41(a)
(best of 16)3
46.81(n)1
37.67(a)1 |
|
92D63
409121 NM_001043220.21 NP_001036685.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
F07C4.123 |
carboxylesterase |
30(a)
(best of 13) |
|
V(7650435-7652416) -- |
ENSEMBL Gene Tree for NLGN3 (if available)
TreeFam Gene Tree for NLGN3 (if available) |
Paralogs
for NLGN3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NLGN3 gene
- NLGN12 CES22 ACHE2 CES4A2 NLGN4X2 NLGN4Y2 CES32 NLGN22
- CES12 CEL2 CES5A2 BCHE2
18 SIMAP similar genes for NLGN3 using alignment to 4 protein entries: NLGN3_HUMAN (see all proteins):DKFZp686F02202 NLGN4X NLGN2 NLGN4Y nlgn1 NLGN1
CES1P1 TG CES3 CES2 BCHE ACHE
CES4A CES8 CES1 CES hBr2 CES5A CEL
NLGN3 for paralogs About GeneDecksing
|
Genomic Variants
for NLGN3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NLGN3 (70364681 - 70391051 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NLGN3
2 CNVs: 74003 7797
Human Gene Mutation Database (HGMD): NLGN3
Locus Specific Mutation Databases (LSDB): NLGN3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLGN3 |
|
Disorders
/ Diseases
for NLGN3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NLGN3 for disorders About GeneDecksing
OMIM gene information: 300336
OMIM disorders: 300425 300494
UniProtKB/Swiss-Prot: NLGN3_HUMAN, Q9NZ94
Defects in NLGN3 may be the cause of susceptibility to autism X-linked type 1 (AUTSX1) [MIM:300425]. AUTSX1 isa pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interactionand communication, restricted and stereotyped patterns of interests and activities, and the presence of developmentalabnormalities by 3 years of age Defects in NLGN3 may be the cause of susceptibility to X-linked Asperger syndrome 1 (ASPGX1) [MIM:300494].ASPGX1 is considered to be a form of childhood autism
12  diseases for NLGN3: About MalaCardsasperger syndrome asperger syndrome susceptibility, x-linked 1 autism susceptibility, x-linked 1 pervasive developmental disorder
autism spectrum disorder atypical autism intellectual disability autistic disorder
neuronitis tuberculosis mycobacterium tuberculosis pancreatitis
3 diseases from the University of Copenhagen DISEASES database for NLGN3:Autistic disorder Asperger syndrome Atypical autism 2 Novoseek disease relationships for NLGN3 gene About this table
GeneTests: NLGN3
Autistic Disorder
Genetic Association Database (GAD): NLGN3
Human Genome Epidemiology (HuGE) Navigator: NLGN3 (6 documents)
Export disorders for NLGN3 gene to outside databases
|
Publications
for NLGN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NLGN3 gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with NLGN3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The structure and expression of the human neuroligin-3 gene. (PubMed id 10767552)1, 2, 3 Philibert R.A.... Ginns E.I. (2000)
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
- NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population. (PubMed id 15389766)1, 4, 9 Gauthier J....Rouleau G.A. (2005)
- Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands. (PubMed id 15274046)1, 4, 9 Vincent J.B....Scherer S.W. (2004)
- Characterization of the neuroligin gene family expression and evolution in zebrafish. (PubMed id 20034102)1, 2 Rissone A.... Cotelli F. (2010)
- Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. (PubMed id 15620359)1, 2 Graf E.R....Craig A.M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. (PubMed id 12669065)1, 2 Jamain S.... Van Maldergem L. (2003)
- Binding of neuroligins to PSD-95. (PubMed id 9278515)1, 2 Irie M.... Suedhof T.C. (1997)
- Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism. (PubMed id 16648374)1, 9 Talebizadeh Z....Butler M.G. (2006)
|
External Searches for NLGN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NLGN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NLGN3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing NLGN3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NLGN3 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NLGN3 |
|
| | |
About This Section
| Patent Information for NLGN3 gene:
Search GeneIP for patents involving NLGN3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NLGN3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for NLGN3 | | OriGene shRNA RFP for NLGN3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NLGN3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLGN3 | | | OriGene Protein Over-expression Lysate for NLGN3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NLGN3 | | OriGene 3'-UTR Clone for NLGN3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NLGN3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NLGN3 | | OriGene Custom Protein Services for NLGN3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NLGN3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLGN3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLGN3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NLGN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLGN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLGN3 |
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| | | | Search Tocris compounds for NLGN3 |
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 | | | NLGN3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLGN3 |
|  |  |  | | | | ThermoFisher Antibodies for NLGN3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLGN3 |
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