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Aliases for NLGN2 Gene

Aliases for NLGN2 Gene

  • Neuroligin 2 2 3
  • KIAA1366 4 6
  • Neuroligin-2 3
  • EC 3.1.1.1 63
  • EC 3.1.1 63

External Ids for NLGN2 Gene

Previous GeneCards Identifiers for NLGN2 Gene

  • GC16M055752
  • GC17P008041
  • GC17P007254
  • GC17P007512
  • GC17P007252
  • GC17P007311
  • GC17P007205

Summaries for NLGN2 Gene

Entrez Gene Summary for NLGN2 Gene

  • This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

GeneCards Summary for NLGN2 Gene

NLGN2 (Neuroligin 2) is a Protein Coding gene. Among its related pathways are Cell adhesion molecules (CAMs). GO annotations related to this gene include receptor activity and neurexin family protein binding. An important paralog of this gene is CES2.

UniProtKB/Swiss-Prot for NLGN2 Gene

  • Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).

Gene Wiki entry for NLGN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLGN2 Gene

Genomics for NLGN2 Gene

Regulatory Elements for NLGN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NLGN2 Gene

Start:
7,404,874 bp from pter
End:
7,419,864 bp from pter
Size:
14,991 bases
Orientation:
Plus strand

Genomic View for NLGN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLGN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLGN2 Gene

Proteins for NLGN2 Gene

  • Protein details for NLGN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFZ4-NLGN2_HUMAN
    Recommended name:
    Neuroligin-2
    Protein Accession:
    Q8NFZ4
    Secondary Accessions:
    • Q9P2I1

    Protein attributes for NLGN2 Gene

    Size:
    835 amino acids
    Molecular mass:
    90820 Da
    Quaternary structure:
    • Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with INADL. Interacts with GPHN (By similarity). Interacts with MDGA1 and MDGA2 (By similarity).

neXtProt entry for NLGN2 Gene

Proteomics data for NLGN2 Gene at MOPED

Selected DME Specific Peptides for NLGN2 Gene

Post-translational modifications for NLGN2 Gene

  • Glycosylation at Asn98, Asn136, and Asn522
  • Modification sites at PhosphoSitePlus

Other Protein References for NLGN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NLGN2 (Neuroligin 2/NLGN2)

Domains for NLGN2 Gene

Protein Domains for NLGN2 Gene

Suggested Antigen Peptide Sequences for NLGN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFZ4

UniProtKB/Swiss-Prot:

NLGN2_HUMAN :
  • Q8NFZ4
Family:
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with NLGN2: view

No data available for Gene Families for NLGN2 Gene

Function for NLGN2 Gene

Molecular function for NLGN2 Gene

UniProtKB/Swiss-Prot Function: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).

Enzyme Numbers (IUBMB) for NLGN2 Gene

Gene Ontology (GO) - Molecular Function for NLGN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005515 protein binding --
GO:0016787 hydrolase activity --
GO:0042043 neurexin family protein binding NAS 10892652
GO:0050839 cell adhesion molecule binding ISS --
genes like me logo Genes that share ontologies with NLGN2: view
genes like me logo Genes that share phenotypes with NLGN2: view

Animal Models for NLGN2 Gene

MGI Knock Outs for NLGN2:

Animal Model Products

miRNA for NLGN2 Gene

miRTarBase miRNAs that target NLGN2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NLGN2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for NLGN2 Gene

Localization for NLGN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLGN2 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLGN2 Gene COMPARTMENTS Subcellular localization image for NLGN2 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NLGN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 NOT extracellular space IBA --
GO:0005887 integral component of plasma membrane ISS --
GO:0009986 cell surface ISS --
GO:0016020 membrane NAS 10892652
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with NLGN2: view

Pathways for NLGN2 Gene

SuperPathways for NLGN2 Gene

genes like me logo Genes that share pathways with NLGN2: view

Pathways by source for NLGN2 Gene

1 KEGG pathway for NLGN2 Gene

Gene Ontology (GO) - Biological Process for NLGN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002087 regulation of respiratory gaseous exchange by neurological system process ISS --
GO:0007158 neuron cell-cell adhesion ISS --
GO:0007416 synapse assembly NAS 10892652
GO:0008152 metabolic process IBA --
GO:0016337 single organismal cell-cell adhesion NAS 10892652
genes like me logo Genes that share ontologies with NLGN2: view

Compounds for NLGN2 Gene

(1) Novoseek inferred chemical compound relationships for NLGN2 Gene

Compound -log(P) Hits PubMed IDs
glutamate 37.3 2
genes like me logo Genes that share compounds with NLGN2: view

Transcripts for NLGN2 Gene

mRNA/cDNA for NLGN2 Gene

Unigene Clusters for NLGN2 Gene

Neuroligin 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NLGN2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NLGN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLGN2 Gene

No ASD Table

Relevant External Links for NLGN2 Gene

GeneLoc Exon Structure for
NLGN2
ECgene alternative splicing isoforms for
NLGN2

Expression for NLGN2 Gene

mRNA expression in normal human tissues for NLGN2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NLGN2 Gene

SOURCE GeneReport for Unigene cluster for NLGN2 Gene Hs.26229

mRNA Expression by UniProt/SwissProt for NLGN2 Gene

Q8NFZ4-NLGN2_HUMAN
Tissue specificity: Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.
genes like me logo Genes that share expressions with NLGN2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NLGN2 Gene

Orthologs for NLGN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NLGN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLGN2 35
  • 99.42 (n)
  • 99.57 (a)
NLGN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NLGN2 35
  • 92.97 (n)
  • 99.52 (a)
NLGN2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NLGN2 35
  • 92.46 (n)
  • 98.68 (a)
NLGN2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nlgn2 35
  • 91.22 (n)
  • 98.08 (a)
Nlgn2 16
Nlgn2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NLGN2 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nlgn2 35
  • 91.78 (n)
  • 98.2 (a)
lizard
(Anolis carolinensis)
Reptilia NLGN2 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nlgn2 35
  • 71.19 (n)
  • 79.97 (a)
zebrafish
(Danio rerio)
Actinopterygii nlgn2a 36
  • 74 (a)
OneToMany
nlgn2b 35
  • 71.46 (n)
  • 77.44 (a)
nlgn2b 36
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003568 35
  • 52.53 (n)
  • 41.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34127 35
  • 50.46 (n)
  • 41.55 (a)
Gli 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea K11G9.3 37
  • 27 (a)
Species with no ortholog for NLGN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NLGN2 Gene

ENSEMBL:
Gene Tree for NLGN2 (if available)
TreeFam:
Gene Tree for NLGN2 (if available)

Paralogs for NLGN2 Gene

Paralogs for NLGN2 Gene

Selected SIMAP similar genes for NLGN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NLGN2: view

Variants for NLGN2 Gene

Sequence variations from dbSNP and Humsavar for NLGN2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2241233 -- 7,415,077(-) TCAGC(A/G)CTGTC reference, synonymous-codon
rs2285480 -- 7,411,900(-) TTTTG(A/C/G/T)GGGGG intron-variant
rs3752031 -- 7,416,823(-) ACAGG(A/G)GGACA intron-variant
rs4289016 -- 7,411,163(-) CCAGC(A/C)TGGCA intron-variant
rs4312330 -- 7,411,217(-) GCCGA(C/G)CGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLGN2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907644 CNV Loss 21882294
nsv523672 CNV Loss 19592680
nsv907645 CNV Loss 21882294
nsv470575 CNV Loss 18288195
dgv3054n71 CNV Loss 21882294
dgv3055n71 CNV Loss 21882294
esv2662967 CNV Deletion 23128226
nsv907650 CNV Loss 21882294
nsv827874 CNV Gain 20364138
nsv526176 CNV Gain 19592680

Relevant External Links for NLGN2 Gene

HapMap Linkage Disequilibrium report
NLGN2
Human Gene Mutation Database (HGMD)
NLGN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLGN2 Gene

Disorders for NLGN2 Gene

(1) University of Copenhagen DISEASES for NLGN2 Gene

Relevant External Links for NLGN2

Genetic Association Database (GAD)
NLGN2
Human Genome Epidemiology (HuGE) Navigator
NLGN2
genes like me logo Genes that share disorders with NLGN2: view

No data available for UniProtKB/Swiss-Prot for NLGN2 Gene

Publications for NLGN2 Gene

  1. Structures, alternative splicing, and neurexin binding of multiple neuroligins. (PMID: 8576240) Ichtchenko K. … SA1dhof T.C. (J. Biol. Chem. 1996) 3 23
  2. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. (PMID: 12669065) Jamain S. … Van Maldergem L. (Nat. Genet. 2003) 3 4
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. The structure and expression of the human neuroligin-3 gene. (PMID: 10767552) Philibert R.A. … Ginns E.I. (Gene 2000) 2 3

Products for NLGN2 Gene

Sources for NLGN2 Gene

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