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NLGN2 Gene

protein-coding   GIFtS: 61
GCID: GC17P007311

Neuroligin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuroligin 21 2
KIAA13663 5
neuroligin-22
EC 3.1.18
EC 3.1.1.18

External Ids:    HGNC: 142901   Entrez Gene: 575552   Ensembl: ENSG000001699927   OMIM: 6064795   UniProtKB: Q8NFZ43   

Export aliases for NLGN2 gene to outside databases

Previous GC identifers: GC16M055752 GC17P008041 GC17P007254 GC17P007512 GC17P007252 GC17P007205


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NLGN2 Gene:
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice
site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous
system synapses. (provided by RefSeq, Jul 2008)

GeneCards Summary for NLGN2 Gene:
NLGN2 (neuroligin 2) is a protein-coding gene. Diseases associated with NLGN2 include autistic disorder, and schizophrenia. GO annotations related to this gene include neurexin family protein binding and receptor activity. An important paralog of this gene is NLGN1.

UniProtKB/Swiss-Prot: NLGN2_HUMAN, Q8NFZ4
Function: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin
family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans
beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric
acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering
of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in
controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for
normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote
the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of
presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin
secretion (By similarity)

Gene Wiki entry for NLGN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NLGN2 gene promoter:
         Max1   Bach2   p300   AP-2gamma   Evi-1   AP-2beta   PPAR-gamma2   AP-2alpha   c-Myc   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLGN2 promoter sequence
   Search Chromatin IP Primers for NLGN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NLGN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.2

NLGN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLGN2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007311:  view genomic region     (about GC identifiers)

Start:
7,308,193 bp from pter      End:
7,323,179 bp from pter
Size:
14,987 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NLGN2_HUMAN, Q8NFZ4 (See protein sequence)
Recommended Name: Neuroligin-2 precursor  
Size: 835 amino acids; 90820 Da
Subunit: Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain
3). Interacts with INADL. Interacts with GPHN (By similarity). Interacts with MDGA1 and MDGA2 (By similarity)
Secondary accessions: Q9P2I1

Explore the universe of human proteins at neXtProt for NLGN2: NX_Q8NFZ4

Explore proteomics data for NLGN2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn98, Asn136, Asn522
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for NLGN2 (Q8NFZ4)
     FGPVVDG  YRLGVLGF 


    See NLGN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065846.1  
    ENSEMBL proteins: 
     ENSP00000461168   ENSP00000305288   ENSP00000461092  

    NLGN2 Human Recombinant Protein Products:

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    NLGN2 Antibody Products:

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    Cloud-Clone Corp. CLIAs for NLGN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000460 Neuroligin
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB

    Graphical View of Domain Structure for InterPro Entry Q8NFZ4

    ProtoNet protein and cluster: Q8NFZ4

    1 Blocks protein domain: IPB000460 Neuroligin signature

    UniProtKB/Swiss-Prot: NLGN2_HUMAN, Q8NFZ4
    Similarity: Belongs to the type-B carboxylesterase/lipase family


    NLGN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NLGN2_HUMAN, Q8NFZ4
    Function: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin
    family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans
    beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric
    acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering
    of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in
    controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for
    normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote
    the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of
    presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin
    secretion (By similarity)

         Enzyme Numbers (IUBMB): EC 3.1.12 EC 3.1.1.12

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IBA--
    GO:0005515protein binding ----
    GO:0016787hydrolase activity ----
    GO:0042043neurexin family protein binding NAS10892652
    GO:0050839cell adhesion molecule binding ISS--
         
    NLGN2 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nlgn2):
     behavior/neurological  growth/size/body  mortality/aging  nervous system  reproductive system 
     respiratory system 

    NLGN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nlgn2tm1Bros for NLGN2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NLGN2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NLGN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NLGN2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NLGN2

    miRNA
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    miRTarBase miRNAs that target NLGN2:
    hsa-mir-378a-3p (MIRT043911)

    Block miRNA regulation of human, mouse, rat NLGN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NLGN2 (see all 78):
    hsa-miR-194* hsa-miR-3130-5p hsa-miR-132* hsa-miR-520e hsa-miR-637 hsa-miR-3613-3p hsa-miR-564 hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidNLGN2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NLGN2
    Predesigned siRNA for gene silencing in human, mouse, rat NLGN2

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    GenScript: all cDNA clones in your preferred vector: NLGN2 (NM_020795)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLGN2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLGN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NLGN2_HUMAN, Q8NFZ4: Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse,
    postsynaptic cell membrane (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity).
    Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes
    with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina.
    Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane ISS--
    GO:0009986cell surface ISS--
    GO:0016020membrane NAS10892652
    GO:0030054cell junction IEA--
    GO:0042734presynaptic membrane IEA--

    NLGN2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NLGN2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1GABA signaling in brain
    GABA signaling in brain0.32
    2Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for NLGN2):
        Cell adhesion molecules (CAMs)


    NLGN2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NLGN2
    Interactions:

        Search GeneGlobe Interaction Network for NLGN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for NLGN2 (Q8NFZ43 ENSP000003052884) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRXN1P584003, ENSP000003851424I2D: score=2 I2D: score=2 STRING: ENSP00000385142
    NRXN2P584013, ENSP000002654594I2D: score=1 I2D: score=1 STRING: ENSP00000265459
    DLG3Q927963, ENSP000003634804I2D: score=2 STRING: ENSP00000363480
    NRXN3Q9Y4C03, ENSP000003383494I2D: score=2 STRING: ENSP00000338349
    MAGI2Q86UL83, ENSP000003461514I2D: score=1 STRING: ENSP00000346151
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002087regulation of respiratory gaseous exchange by neurological system process ISS--
    GO:0007158neuron cell-cell adhesion ISS--
    GO:0007416synapse assembly NAS10892652
    GO:0008152metabolic process ----
    GO:0016337cell-cell adhesion NAS10892652

    NLGN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NLGN2

    1 Novoseek inferred chemical compound relationship for NLGN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 37.3 3 15620359 (2)



    NLGN2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NLGN2 gene: 
    NM_020795.3  

    Unigene Cluster for NLGN2:

    Neuroligin 2
    Hs.26229  [show with all ESTs]
    Unigene Representative Sequence: NM_020795
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575301 ENST00000572893 ENST00000302926(uc002ggt.1) ENST00000570940

    miRNA
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    Block miRNA regulation of human, mouse, rat NLGN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NLGN2 (see all 78):
    hsa-miR-194* hsa-miR-3130-5p hsa-miR-132* hsa-miR-520e hsa-miR-637 hsa-miR-3613-3p hsa-miR-564 hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidNLGN2 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat NLGN2

    Additional mRNA sequence: 

    AB037787.1 AF376802.1 BC069217.1 

    7 DOTS entries:

    DT.316494  DT.97811826  DT.95086667  DT.95192853  DT.100755203  DT.105182  DT.91915129 

    Selected AceView cDNA sequences (see all 179):

    AF376802 BM800364 AI864673 AI613237 AI167716 BU737882 AA844555 BM702495 
    AI198253 AI582243 AW205858 BM719481 BX111717 BM700081 AI264524 BF115661 
    AA722093 N47600 CN485300 F09077 AI768237 BM682805 AI471251 AA976787 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NLGN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCAGCCAC
    NLGN2 Expression
    About this image

    NLGN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NLGN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.26229

    UniProtKB/Swiss-Prot: NLGN2_HUMAN, Q8NFZ4
    Tissue specificity: Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of
    Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLGN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NLGN2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nlgn21 , 5 neuroligin 21, 5 91.22(n)1
    98.08(a)1
      11 (42.89 cM)5
    2168561  NM_198862.21  NP_942562.21 
     698231225 
    lizard
    (Anolis carolinensis)
    Reptilia NLGN26
    Neuroligin 2; Uncharacterized protein
    77(a)
    1 ↔ 1
    AAWZ02034793(18486-64892)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nlgn21 neuroligin 2 71.19(n)
    79.97(a)
      100329187  XM_002944419.2  XP_002944465.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nlgn2b1 neuroligin 2b 71.46(n)
    77.44(a)
      556158  NM_001166329.1  NP_001159801.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gli3
    CG341271
    establishment of blood/nerve barrier
    serine esterase3
    CG341271
    31(a)3
    50.46(n)1
    41.55(a)1
      35D43
    409121  NM_001043220.31  NP_001036685.21 


    ENSEMBL Gene Tree for NLGN2 (if available)
    TreeFam Gene Tree for NLGN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NLGN2 gene
    NLGN12  CES22  ACHE2  CES4A2  NLGN4X2  NLGN4Y2  CES32  NLGN32  
    CES12  CEL2  CES5A2  BCHE2  
    14 SIMAP similar genes for NLGN2 using alignment to 2 protein entries:     NLGN2_HUMAN (see all proteins):
    NLGN3    DKFZp686F02202    CES5A    NLGN4X    CES3    TG
    CES1P1    NLGN4Y    nlgn1    NLGN1    CES2    CES4A
    BCHE    ACHE

    NLGN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NLGN2 (see all 302)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887936841,2
    --7309518(+) GGCAAA/GAGCTG 1 -- us2k10--------
    rs1808114431,2
    --7309522(+) AGAGCC/TGGGGC 1 -- us2k10--------
    rs1390950851,2
    C--7309677(+) ACTGAA/GGCAGA 1 -- us2k10--------
    rs1439848531,2
    C--7309750(+) GAAAAG/TGAGAT 1 -- us2k10--------
    rs1846554191,2
    --7309774(+) GCCCCA/GAGCCA 1 -- us2k10--------
    rs1468891311,2
    --7309913(+) GCGGGC/TTGGCG 1 -- us2k10--------
    rs80657701,2
    C,A--7309972(+) GGGGGC/G/TGGGGG 1 -- us2k1 tfbs30--------
    rs353864901,2
    C,F--7310006(+) GTGTCT/CGCCCC 1 -- us2k13Minor allele frequency- C:0.19NA 124
    rs1151061951,2
    F--7310077(+) AGCAAC/ATGTAG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1903839261,2
    --7310088(+) GGGGGG/TTGGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NLGN2 (7308193 - 7323179 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NLGN2 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662967CNV Deletion23128226
    esv2422288CNV Deletion17116639
    dgv3054n71CNV Loss21882294
    dgv3055n71CNV Loss21882294
    nsv907650CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv523672CNV Loss19592680
    nsv907645CNV Loss21882294
    nsv470575CNV Loss18288195
    nsv907644CNV Loss21882294

    Human Gene Mutation Database (HGMD): NLGN2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NLGN2
    DNA2.0 Custom Variant and Variant Library Synthesis for NLGN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606479    OMIM disorders: --

    5 diseases for NLGN2:    About MalaCards
    autistic disorder    schizophrenia    tuberculosis    neuronitis
    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for NLGN2:
    Autistic disorder

    NLGN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NLGN2
    Human Genome Epidemiology (HuGE) Navigator: NLGN2 (1 document)

    Export disorders for NLGN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NLGN2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with NLGN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    2. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. (PubMed id 12669065)1, 2 Jamain S.... Van Maldergem L. (Nat. Genet. 2003)
    3. The structure and expression of the human neuroligin-3 gene. (PubMed id 10767552)1, 3 Philibert R.A.... Ginns E.I. (Gene 2000)
    4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    6. Binding of neuroligins to PSD-95. (PubMed id 9278515)1, 2 Irie M.... Suedhof T.C. (Science 1997)
    7. Structures, alternative splicing, and neurexin binding of multiple neuroligins. (PubMed id 8576240)1, 9 Ichtchenko K....SA1dhof T.C. (J. Biol. Chem. 1996)
    8. MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development. (PubMed id 23248271)1 Lee K....Ko J. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    9. Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic I^ cell function. (PubMed id 22528485)1 Suckow A.T....Chessler S.D. (J. Biol. Chem. 2012)
    10. Identification and functional characterization of rare mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia. (PubMed id 21551456)1 Sun C....Chen C.H. (Hum. Mol. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 57555 HGNC: 14290 AceView: NLGN2 Ensembl:ENSG00000169992 euGenes: HUgn57555
    ECgene: NLGN2 Kegg: 57555 H-InvDB: NLGN2

    (According to HUGE)
    About This Section

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    HUGE: KIAA1366

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NLGN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NLGN2 gene:
    Search GeneIP for patents involving NLGN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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