Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NLGN2 Gene

protein-coding   GIFtS: 59
GCID: GC17P007311

neuroligin 2

 Explore 6 diseases affiliated with
NLGN2 via our new
 Human Malady Compendium 
Biological research products
for NLGN2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Neuroligin 21 2
KIAA13661 3 5
Neuroligin-21
EC 3.1.18
EC 3.1.1.18

External Ids:    HGNC: 142901   Entrez Gene: 575552   Ensembl: ENSG000001699927   OMIM: 6064795   UniProtKB: Q8NFZ43   

Export aliases for NLGN2 gene to outside databases

Previous GC identifers: GC16M055752 GC17P008041 GC17P007254 GC17P007512 GC17P007252 GC17P007205


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NLGN2:
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice
site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system
synapses. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NLGN2_HUMAN, Q8NFZ4
Function: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin
family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta
cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid
receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of
postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the
ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal
amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial
formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic
structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By
similarity)

Gene Wiki entry for NLGN2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NLGN2 gene promoter:
         Max1   Bach2   p300   AP-2gamma   Evi-1   AP-2beta   PPAR-gamma2   AP-2alpha   c-Myc   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLGN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NLGN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLGN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.2

NLGN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLGN2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007311:  view genomic region     (about GC identifiers)

Start:
7,308,193 bp from pter      End:
7,323,179 bp from pter
Size:
14,987 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NLGN2_HUMAN, Q8NFZ4 (See protein sequence)
Recommended Name: Neuroligin-2 precursor  
Size: 835 amino acids; 90820 Da
Subunit: Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3).
Interacts with INADL. Interacts with GPHN (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse,
postsynaptic cell membrane (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity).
Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with
GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes
with GABRG2 at inhibitory synapses in the retina (By similarity)
Secondary accessions: Q9P2I1

Explore the universe of human proteins at neXtProt for NLGN2: NX_Q8NFZ4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NFZ4

  • 2 DME Specific Peptides for NLGN2 (Q8NFZ4)
     FGPVVDG  YRLGVLGF 

    NLGN2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065846.1  
    ENSEMBL proteins: 
     ENSP00000461168   ENSP00000305288   ENSP00000461092  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NLGN2 (Neuroligin 2/NLGN2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for NLGN2 
    GenScript Custom Purified and Recombinant Proteins Services for NLGN2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NLGN2

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane ISS--
    GO:0009986cell surface ISS--
    GO:0016020membrane NAS10892652
    GO:0030054cell junction IEA--
    GO:0042734presynaptic membrane IEA--


    NLGN2 for ontologies           About GeneDecksing



    NLGN2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NLGN2
    R&D Systems Antibodies for NLGN2 (Neuroligin 2/NLGN2)
    OriGene Antibodies: NLGN2
    OriGene Custom Antibody Services for NLGN2 
    GenScript Custom Superior Antibodies Services for NLGN2
    Novus Biologicals NLGN2 Antibody
    Search for Antibodies for NLGN2 at Abcam  
    Uscn Antibodies for NLGN2
    ThermoFisher Antibodies for NLGN2

    Assay Products for NLGN2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NLGN2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NLGN2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NLGN2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000460 Neuroligin
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB

    Graphical View of Domain Structure for InterPro Entry Q8NFZ4

    ProtoNet protein and cluster: Q8NFZ4

    1 Blocks protein family: IPB000460 Neuroligin signature

    UniProtKB/Swiss-Prot: NLGN2_HUMAN, Q8NFZ4
    Similarity: Belongs to the type-B carboxylesterase/lipase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NLGN2_HUMAN, Q8NFZ4
    Function: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin
    family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta
    cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid
    receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of
    postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the
    ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal
    amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial
    formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic
    structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By
    similarity)

    Enzyme Numbers (IUBMB): EC 3.1.12 EC 3.1.1.12

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: NLGN2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NLGN2
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate NLGN2 (see all 78):
    hsa-miR-194* hsa-miR-3130-5p hsa-miR-132* hsa-miR-520e hsa-miR-637 hsa-miR-3613-3p hsa-miR-564 hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidNLGN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NLGN2 (see all 7)
    OriGene shRNA RFP: NLGN2
    OriGene siRNA: NLGN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NLGN2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NLGN2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NLGN2 (NM_020795)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NLGN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLGN2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NLGN2
    Search LifeMap BioReagents cell lines for NLGN2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLGN2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004091NOT carboxylesterase activity IKR--
    GO:0004872receptor activity IBA--
    GO:0042043neurexin family protein binding NAS10892652
    GO:0050839cell adhesion molecule binding ISS--


    NLGN2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Nlgn2tm1Bros for NLGN2
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nlgn2):
     behavior/neurological  growth/size  mortality/aging  nervous system  reproductive system 
     respiratory system 

    NLGN2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)1.00
    2GABA A receptor activation
    GABA signaling in brain0.26

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NLGN2
        GABA signaling in brain



    1         Kegg Pathway  (Kegg details for NLGN2):
        Cell adhesion molecules (CAMs)


    NLGN2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NLGN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/17 Interacting proteins for NLGN2 (Q8NFZ43 ENSP000003052884) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRXN1P584003, ENSP000003851424I2D: score=2 I2D: score=2 STRING: ENSP00000385142
    NRXN2P584013, ENSP000002654594I2D: score=1 I2D: score=1 STRING: ENSP00000265459
    DLG4P783523, ENSP000002938134I2D: score=4 STRING: ENSP00000293813
    DLG3Q927963, ENSP000003634804I2D: score=2 STRING: ENSP00000363480
    NRXN3Q9Y4C03, ENSP000003383494I2D: score=2 STRING: ENSP00000338349
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002087regulation of respiratory gaseous exchange by neurological system process IEA--
    GO:0007158neuron cell-cell adhesion ISS--
    GO:0007416synapse assembly NAS10892652
    GO:0016337cell-cell adhesion NAS10892652
    GO:0019233sensory perception of pain IEA--


    NLGN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NLGN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NLGN2
    1 Novoseek chemical compound relationship for NLGN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 37.3 3 15620359 (2)

    Search CenterWatch for drugs/clinical trials and news about NLGN2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NLGN2 gene: 
    NM_020795.2  

    Unigene Cluster for NLGN2:

    Neuroligin 2
    Hs.26229  [show with all ESTs]
    Unigene Representative Sequence: NM_020795
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575301 ENST00000572893 ENST00000302926(uc002ggt.1) ENST00000570940


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: NLGN2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NLGN2
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate NLGN2 (see all 78):
    hsa-miR-194* hsa-miR-3130-5p hsa-miR-132* hsa-miR-520e hsa-miR-637 hsa-miR-3613-3p hsa-miR-564 hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidNLGN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NLGN2 (see all 7)
    OriGene shRNA RFP: NLGN2
    OriGene siRNA: NLGN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NLGN2
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NLGN2 (NM_020795)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NLGN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLGN2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLGN2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NLGN2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLGN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLGN2

    Additional cDNA sequence: 

    AB037787.1 AF376802.1 BC069217.1 

    7 DOTS entries:

    DT.316494  DT.97811826  DT.95086667  DT.95192853  DT.100755203  DT.105182  DT.91915129 

    24/179 AceView cDNA sequences (see all 179):

    AI093247 AW205858 AF376802 BM700081 AI582243 BM702495 AA844555 AA976787 
    AI167716 BX111717 AA722093 AI864673 CN485300 BF115661 BU737882 AI285294 
    NM_020795 AI613237 AI198253 BM663814 AI337820 BM719481 BG152615 AI768237 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NLGN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTCAGCCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NLGN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NLGN2

    SOURCE GeneReport for Unigene cluster: Hs.26229

    UniProtKB/Swiss-Prot: NLGN2_HUMAN, Q8NFZ4
    Tissue specificity: Expressed in the blood vessel walls. Detected in colon, brian and pancreas islets of Langerhans (at
    protein level). Detected in brain, and at lower levels in pancreas islet beta cells

        SABiosciences Custom PCR Arrays for NLGN2
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLGN2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NLGN2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLGN2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLGN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLGN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NLGN2 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia D2X2H8_ANOCA6
    Neuroligin 2
    78(a)
    1 ↔ 1
    AAWZ02034793(18913-64892)
    zebrafish
    (Danio rerio)
    Actinopterygii nlgn2b1 neuroligin 2b 72.49(n)
    78.84(a)
      556158  NM_001166329.1  NP_001159801.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gli3 establishment of blood/nerve barrier serine
    esterase
    31(a)   35D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea K11G9.33 esterase 27(a)   V(6673057-6674599)   --


    ENSEMBL Gene Tree for NLGN2 (if available)
    TreeFam Gene Tree for NLGN2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NLGN2 gene
    NLGN12  CES22  ACHE2  CES4A2  NLGN4X2  NLGN4Y2  CES32  NLGN32  
    CES12  CEL2  CES5A2  BCHE2  
    14 SIMAP similar genes for NLGN2 using alignment to 2 protein entries:     NLGN2_HUMAN (see all proteins):
    NLGN3    DKFZp686F02202    CES5A    NLGN4X    CES3    NLGN4Y
    TG    CES1P1    nlgn1    NLGN1    CES2    CES4A
    BCHE    ACHE

    NLGN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/242 NCBI SNPs in NLGN2 are shown (see all 242    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887936841,2
    --7309518(+) GGCAAA/GAGCTG 1 -- us2k10--------
    rs1808114431,2
    --7309522(+) AGAGCC/TGGGGC 1 -- us2k10--------
    rs1390950851,2
    --7309677(+) ACTGAA/GGCAGA 1 -- us2k10--------
    rs1439848531,2
    --7309750(+) GAAAAG/TGAGAT 1 -- us2k10--------
    rs1846554191,2
    --7309774(+) GCCCCA/GAGCCA 1 -- us2k10--------
    rs1468891311,2
    --7309913(+) GCGGGC/TTGGCG 1 -- us2k10--------
    rs80657701,2
    C,A--7309972(+) GGGGGC/G/TGGGGG 1 -- us2k1 tfbs30--------
    rs353864901,2
    C,F,--7310006(+) GTGTCT/CGCCCC 1 -- us2k13Minor allele frequency- C:0.19NA 124
    rs1151061951,2
    --7310077(+) AGCAAC/ATGTAG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1903839261,2
    --7310088(+) GGGGGG/TTGGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NLGN2 (7308193 - 7323179 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NLGN2: --
    Human Gene Mutation Database (HGMD): NLGN2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLGN2
    DNA2.0 Custom Variant and Variant Library Synthesis for NLGN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NLGN2 for disorders           About GeneDecksing

    OMIM gene information: 606479    OMIM disorders: --

    6 diseases for NLGN2:    About MalaCards
    neuronitis    mental disorders    schizophrenia    tuberculosis
    mycobacterium tuberculosis    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for NLGN2:
    Autistic disorder
    Human Genome Epidemiology (HuGE) Navigator: NLGN2 (1 document)

    Export disorders for NLGN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NLGN2 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with NLGN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. (PubMed id 12669065)1, 2 Jamain S.... Van Maldergem L. (2003)
    2. The structure and expression of the human neuroligin-3 gene. (PubMed id 10767552)1, 3 Philibert R.A.... Ginns E.I. (2000)
    3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 3 Nagase T.... Ohara O. (2000)
    5. Binding of neuroligins to PSD-95. (PubMed id 9278515)1, 2 Irie M.... Suedhof T.C. (1997)
    6. Structures, alternative splicing, and neurexin binding of multiple neuroligins. (PubMed id 8576240)1, 9 Ichtchenko K....Sudhof T.C. (1996)
    7. Transcellular neuroligin-2 interactions enhance insuli n secretion and are integral to pancreatic b cell function. (PubMed id 22528485)1 Suckow A.T....Chessler S.D. (2012)
    8. Identification and functional characterization of rar e mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia. (PubMed id 21551456)1 Sun C....Chen C.H. (2011)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    10. The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions. (PubMed id 19926856)2 Bottos A.... Arese M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57555 HGNC: 14290 AceView: NLGN2 Ensembl:ENSG00000169992 euGenes: HUgn57555
    ECgene: NLGN2 Kegg: 57555 H-InvDB: NLGN2

    (According to HUGE)
    About This Section
    HUGE: KIAA1366

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NLGN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NLGN2 gene:
    Search GeneIP for patents involving NLGN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of NLGN2
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NLGN2 (Neuroligin 2/NLGN2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for NLGN2 (Neuroligin 2/NLGN2)  
     OriGene Antibodies for NLGN2   OriGene shRNA RFP for NLGN2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NLGN2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLGN2  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NLGN2   OriGene 3'-UTR Clone for NLGN2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLGN2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NLGN2   OriGene Custom Protein Services for NLGN2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NLGN2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLGN2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLGN2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NLGN2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLGN2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLGN2
     GenScript Custom Purified and Recombinant Proteins Services for NLGN2 GenScript cDNA clones with any tag delivered in your preferred vector for NLGN2
     GenScript Custom Assay Services for NLGN2 GenScript Custom Superior Antibodies Services for NLGN2
     GenScript Custom overexpressing Cell Line Services for NLGN2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NLGN2 promoter
     Search Chromatin IP Primers for NLGN2
     RT2 qPCR Primer Assay in human, mouse, rat NLGN2
     Search GNC Networks for NLGN2
     SABiosciences Custom PCR Arrays for NLGN2
     Search Tocris compounds for NLGN2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NLGN2 antibodies
     Search for Antibodies for NLGN2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NLGN2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NLGN2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NLGN2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLGN2
     SwitchGear 3'UTR luciferase reporter plasmids for NLGN2
     SwitchGear Promoter luciferase reporter plasmids for NLGN2
     ThermoFisher Antibodies for NLGN2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLGN2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NLGN2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4