External Ids for NLGN1 Gene
Previous GeneCards Identifiers for NLGN1 Gene
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
GeneCards Summary for NLGN1 Gene
NLGN1 (Neuroligin 1) is a Protein Coding gene. Diseases associated with NLGN1 include Corneal Dystrophy, Avellino Type and Corneal Granular Dystrophy. Among its related pathways are Protein-protein interactions at synapses and Circadian rythm related genes. GO annotations related to this gene include hydrolase activity and protein dimerization activity. An important paralog of this gene is NLGN4X.
UniProtKB/Swiss-Prot for NLGN1 Gene
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.