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Aliases for NLGN1 Gene

Aliases for NLGN1 Gene

  • Neuroligin 1 2 3
  • Neuroligin-1 3
  • EC 3.1.1.1 63
  • KIAA1070 4
  • EC 3.1.1 63
  • NL1 3

External Ids for NLGN1 Gene

Previous GeneCards Identifiers for NLGN1 Gene

  • GC03P170368
  • GC03P174328
  • GC03P174704
  • GC03P174437
  • GC03P174635
  • GC03P173114
  • GC03P170489

Summaries for NLGN1 Gene

Entrez Gene Summary for NLGN1 Gene

  • This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

GeneCards Summary for NLGN1 Gene

NLGN1 (Neuroligin 1) is a Protein Coding gene. Among its related pathways are Cell adhesion molecules (CAMs). GO annotations related to this gene include receptor activity and cell adhesion molecule binding. An important paralog of this gene is CES2.

UniProtKB/Swiss-Prot for NLGN1 Gene

  • Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.

Gene Wiki entry for NLGN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLGN1 Gene

Genomics for NLGN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NLGN1 Gene

Start:
173,396,284 bp from pter
End:
174,286,644 bp from pter
Size:
890,361 bases
Orientation:
Plus strand

Genomic View for NLGN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLGN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLGN1 Gene

Proteins for NLGN1 Gene

  • Protein details for NLGN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2Q7-NLGN1_HUMAN
    Recommended name:
    Neuroligin-1
    Protein Accession:
    Q8N2Q7
    Secondary Accessions:
    • Q9UPT2

    Protein attributes for NLGN1 Gene

    Size:
    840 amino acids
    Molecular mass:
    93835 Da
    Quaternary structure:
    • Interacts with NRXN1, NRXN2 and NRXN3. Interacts with NLGN3. Interacts with AIP1 and PDZRN3 (By similarity). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with GOPC.
    SequenceCaution:
    • Sequence=BAA83022.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NLGN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NLGN1 Gene

Proteomics data for NLGN1 Gene at MOPED

Selected DME Specific Peptides for NLGN1 Gene

Post-translational modifications for NLGN1 Gene

  • Glycosylation at Asn109, Asn300, Asn340, Asn544, Ser660, Thr664, Ser665, Thr669, Ser680, and Ser683
  • Modification sites at PhosphoSitePlus

Other Protein References for NLGN1 Gene

Antibody Products

  • R&D Systems Antibodies for NLGN1 (Neuroligin 1/NLGN1)

Domains for NLGN1 Gene

Protein Domains for NLGN1 Gene

Suggested Antigen Peptide Sequences for NLGN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N2Q7

UniProtKB/Swiss-Prot:

NLGN1_HUMAN :
  • Q8N2Q7
Family:
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with NLGN1: view

No data available for Gene Families for NLGN1 Gene

Function for NLGN1 Gene

Molecular function for NLGN1 Gene

UniProtKB/Swiss-Prot Function: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.

Enzyme Numbers (IUBMB) for NLGN1 Gene

Gene Ontology (GO) - Molecular Function for NLGN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity ISS --
GO:0005515 protein binding --
GO:0016787 hydrolase activity --
GO:0030165 PDZ domain binding IDA 17474715
GO:0042043 neurexin family protein binding ISS --
genes like me logo Genes that share ontologies with NLGN1: view
genes like me logo Genes that share phenotypes with NLGN1: view

Animal Models for NLGN1 Gene

MGI Knock Outs for NLGN1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NLGN1

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for NLGN1 Gene

Localization for NLGN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLGN1 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Detected at dendritic spines. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLGN1 Gene COMPARTMENTS Subcellular localization image for NLGN1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for NLGN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 NOT extracellular space IBA --
GO:0005794 Golgi apparatus ISS --
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane ISS --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with NLGN1: view

Pathways for NLGN1 Gene

SuperPathways for NLGN1 Gene

genes like me logo Genes that share pathways with NLGN1: view

Pathways by source for NLGN1 Gene

1 KEGG pathway for NLGN1 Gene

Gene Ontology (GO) - Biological Process for NLGN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA --
GO:0006605 protein targeting ISS --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS --
GO:0007158 neuron cell-cell adhesion TAS 15797875
GO:0007399 nervous system development ISS --
genes like me logo Genes that share ontologies with NLGN1: view

Compounds for NLGN1 Gene

(1) Novoseek inferred chemical compound relationships for NLGN1 Gene

Compound -log(P) Hits PubMed IDs
nmda 33.4 2
genes like me logo Genes that share compounds with NLGN1: view

Transcripts for NLGN1 Gene

Unigene Clusters for NLGN1 Gene

Neuroligin 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NLGN1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLGN1 Gene

No ASD Table

Relevant External Links for NLGN1 Gene

GeneLoc Exon Structure for
NLGN1
ECgene alternative splicing isoforms for
NLGN1

Expression for NLGN1 Gene

mRNA expression in normal human tissues for NLGN1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NLGN1 Gene

SOURCE GeneReport for Unigene cluster for NLGN1 Gene Hs.478289

mRNA Expression by UniProt/SwissProt for NLGN1 Gene

Q8N2Q7-NLGN1_HUMAN
Tissue specificity: Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.
genes like me logo Genes that share expressions with NLGN1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NLGN1 Gene

Orthologs for NLGN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NLGN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLGN1 35
  • 99.51 (n)
  • 99.88 (a)
NLGN1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NLGN1 35
  • 95.06 (n)
  • 98.66 (a)
NLGN1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NLGN1 35
  • 95.22 (n)
  • 98.91 (a)
NLGN1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nlgn1 35
  • 91.21 (n)
  • 98.06 (a)
Nlgn1 16
Nlgn1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NLGN1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nlgn1 35
  • 91.13 (n)
  • 98.18 (a)
chicken
(Gallus gallus)
Aves NLGN1 35
  • 87 (n)
  • 95.26 (a)
NLGN1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NLGN1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nlgn1 35
  • 80.06 (n)
  • 89.73 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18973 35
nlgn1 35
  • 73.91 (n)
  • 83.92 (a)
nlgn1 36
  • 87 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7529 37
  • 27 (a)
CG5030 37
  • 40 (a)
alpha-Est2 37
  • 28 (a)
alpha-Est5 37
  • 33 (a)
Est-6 37
  • 30 (a)
CG6414 37
  • 30 (a)
alpha-Est8 37
  • 28 (a)
CG9289 37
  • 27 (a)
CG9287 37
  • 27 (a)
CG6018 37
  • 30 (a)
CG3841 37
  • 29 (a)
CG4382 37
  • 27 (a)
CG5397 37
  • 26 (a)
CG10175 37
  • 30 (a)
Est-P 37
  • 30 (a)
CG10339 37
  • 29 (a)
Gli 37
  • 31 (a)
neuroligin 37
  • 34 (a)
Jhe 37
  • 28 (a)
alpha-Est4 37
  • 28 (a)
clt 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea F55D10.3 37
  • 27 (a)
K11G9.1 37
  • 26 (a)
F15A8.6 37
  • 27 (a)
B0238.13 37
  • 31 (a)
T28C12.4a 37
  • 29 (a)
F13H6.4 37
  • 27 (a)
K11G9.2 37
  • 29 (a)
R173.3 37
  • 30 (a)
ges-1 37
  • 27 (a)
B0238.7 37
  • 26 (a)
T28C12.4b 37
  • 29 (a)
Y71H2AM.13 37
  • 28 (a)
C52A10.1 37
  • 29 (a)
K11G9.3 37
  • 28 (a)
F07C4.12 37
  • 30 (a)
T07H6.1a 37
  • 26 (a)
F13H6.3 37
  • 28 (a)
Species with no ortholog for NLGN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NLGN1 Gene

ENSEMBL:
Gene Tree for NLGN1 (if available)
TreeFam:
Gene Tree for NLGN1 (if available)

Paralogs for NLGN1 Gene

Paralogs for NLGN1 Gene

Selected SIMAP similar genes for NLGN1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NLGN1: view

Variants for NLGN1 Gene

Sequence variations from dbSNP and Humsavar for NLGN1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs34255 -- 173,462,353(-) GCTAA(A/G)AAGTT intron-variant
rs34256 -- 173,461,940(-) TTTTC(A/T)TGGCT intron-variant
rs34257 -- 173,461,347(-) ATGGG(A/T)CTGGG intron-variant
rs166025 -- 173,424,185(+) gaagc(C/T)gcacg intron-variant
rs187448 -- 173,434,993(-) AAGTG(A/T)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLGN1 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
dgv1537e1 CNV Complex 17122850
nsv4120 CNV Insertion 18451855
essv15193 CNV CNV 17122850
nsv10358 CNV Loss 18304495
dgv896e199 CNV Deletion 23128226
esv25261 CNV Loss 19812545
esv2421940 CNV Deletion 20811451
essv8020 CNV CNV 17122850
nsv442884 CNV CNV 18776908
nsv514188 CNV Loss 21397061
dgv628n27 CNV Gain 19166990
dgv5348n71 CNV Gain 21882294
dgv304n21 CNV Gain 19592680
esv2726215 CNV Deletion 23290073
esv259627 OTHER Complex 20981092
esv259834 OTHER Complex 20981092
nsv10359 CNV Gain 18304495
nsv877997 CNV Gain 21882294
nsv441850 CNV CNV 18776908
esv2678513 CNV Deletion 23128226
dgv629n27 CNV Gain 19166990
esv33113 CNV Gain 17666407
esv2726216 CNV Deletion 23290073
esv2329791 CNV Deletion 18987734
esv2726217 CNV Deletion 23290073
nsv238018 CNV Loss 16902084
esv2726219 CNV Deletion 23290073
esv2726220 CNV Deletion 23290073
nsv818192 CNV Gain 17921354
nsv829796 CNV Gain 17160897
dgv5349n71 CNV Loss 21882294
esv2726221 CNV Deletion 23290073
nsv471071 CNV Loss 18288195
esv989077 CNV Insertion 20482838
nsv236399 CNV Loss 16902084
nsv878001 CNV Loss 21882294
dgv305n21 CNV Gain 19592680
esv2726222 CNV Deletion 23290073
esv2658368 CNV Deletion 23128226
esv2665338 CNV Deletion 23128226
nsv4122 CNV Loss 18451855
nsv507137 CNV Insertion 20534489
esv2670121 CNV Deletion 23128226
nsv520908 CNV Loss 19592680
esv1219198 CNV Insertion 17803354
esv2678094 CNV Deletion 23128226
nsv4123 CNV Insertion 18451855
nsv461018 CNV Loss 19166990
esv1345007 CNV Insertion 17803354
esv1173402 CNV Insertion 17803354
nsv878002 CNV Gain 21882294
nsv878003 CNV Loss 21882294

Relevant External Links for NLGN1 Gene

HapMap Linkage Disequilibrium report
NLGN1
Human Gene Mutation Database (HGMD)
NLGN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLGN1 Gene

Disorders for NLGN1 Gene

(1) University of Copenhagen DISEASES for NLGN1 Gene

Relevant External Links for NLGN1

Genetic Association Database (GAD)
NLGN1
Human Genome Epidemiology (HuGE) Navigator
NLGN1
genes like me logo Genes that share disorders with NLGN1: view

No data available for UniProtKB/Swiss-Prot for NLGN1 Gene

Publications for NLGN1 Gene

  1. Analysis of four neuroligin genes as candidates for autism. (PMID: 16077734) Ylisaukko-oja T. … JAorvelAo I. (Eur. J. Hum. Genet. 2005) 3 23
  2. Neuroligin 1: a splice site-specific ligand for beta-neurexins. (PMID: 7736595) Ichtchenko K. … SA1dhof T.C. (Cell 1995) 3 23
  3. Structures, alternative splicing, and neurexin binding of multiple neuroligins. (PMID: 8576240) Ichtchenko K. … SA1dhof T.C. (J. Biol. Chem. 1996) 3 23
  4. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. (PMID: 10892652) Scheiffele P. … Serafini T. (Cell 2000) 3 23
  5. Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. (PMID: 14522992) Comoletti D. … Taylor P. (J. Biol. Chem. 2003) 3 23

Products for NLGN1 Gene

Sources for NLGN1 Gene

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