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Aliases for NLE1 Gene

Aliases for NLE1 Gene

  • Notchless Homolog 1 2 3 5
  • Notchless Gene Homolog, (Drosophila) 2
  • Notchless Homolog (Drosophila) 2
  • Notchless Protein Homolog 1 3
  • Notchless Gene Homolog 3
  • NLE 3

External Ids for NLE1 Gene

Previous HGNC Symbols for NLE1 Gene

  • NLE

Previous GeneCards Identifiers for NLE1 Gene

  • GC17M030472
  • GC17M033458
  • GC17M029643

Summaries for NLE1 Gene

GeneCards Summary for NLE1 Gene

NLE1 (Notchless Homolog 1) is a Protein Coding gene. An important paralog of this gene is TEP1.

UniProtKB/Swiss-Prot for NLE1 Gene

  • Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).

Gene Wiki entry for NLE1 Gene

Additional gene information for NLE1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLE1 Gene

Genomics for NLE1 Gene

Regulatory Elements for NLE1 Gene

Enhancers for NLE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H035212 1.4 FANTOM5 Ensembl ENCODE dbSUPER 21.6 -72.8 -72777 5.4 PKNOX1 ETV1 ZNF133 BATF GABPA OSR2 PRDM6 ZNF157 CUX1 SPI1 SLFN5 NLE1 SLFN12L AP2B1 LINC02001 UNC45B ZNF830 SLC35G3
GH17H035172 0.9 Ensembl ENCODE 24.1 -29.7 -29657 0.9 CTCF ZNF654 CEBPB REST CEBPG ATF2 RAD21 JUND SMC3 ATF7 NLE1 SLFN5 SLFN12L GC17M035166 GC17M035176
GH17H035020 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +119.6 119556 3.9 BCOR JUN ZMYM3 SIN3A MAX ZIC2 RAD21 POLR2A FOS RUNX3 LIG3 RNU6-840P SLFN12L NLE1 SLFN5 ZNF830 CCT6B RFFL ENSG00000273687 GC17P035052
GH17H035256 1.5 Ensembl ENCODE dbSUPER 10 -114.7 -114722 1.8 FOXA2 FEZF1 FOS TSHZ1 ZNF518A ZNF610 GLIS1 ZNF624 STAT3 WT1 SLFN5 RAD51D NLE1 SLFN12L ENSG00000267074 LOC105371932 ENSG00000267364
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NLE1 on UCSC Golden Path with GeneCards custom track

Promoters for NLE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093451 515 1601 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143

Genomic Locations for NLE1 Gene

Genomic Locations for NLE1 Gene
13,563 bases
Minus strand

Genomic View for NLE1 Gene

Genes around NLE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLE1 Gene

Proteins for NLE1 Gene

  • Protein details for NLE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Notchless protein homolog 1
    Protein Accession:
    Secondary Accessions:
    • O60868
    • Q59GJ8
    • Q9BU54

    Protein attributes for NLE1 Gene

    485 amino acids
    Molecular mass:
    53320 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD92348.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NLE1 Gene


neXtProt entry for NLE1 Gene

Post-translational modifications for NLE1 Gene

  • Ubiquitination at posLast=224224 and Lys326
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NLE1 Gene

Domains & Families for NLE1 Gene

Gene Families for NLE1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NLE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NLE1/RSA4 family.
  • Belongs to the NLE1/RSA4 family.
genes like me logo Genes that share domains with NLE1: view

Function for NLE1 Gene

Molecular function for NLE1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).

Phenotypes From GWAS Catalog for NLE1 Gene

genes like me logo Genes that share phenotypes with NLE1: view

Animal Models for NLE1 Gene

MGI Knock Outs for NLE1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NLE1 Gene

Localization for NLE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLE1 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NLE1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005840 ribosome IBA --
genes like me logo Genes that share ontologies with NLE1: view

Pathways & Interactions for NLE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0001756 somitogenesis IEA --
GO:0001822 kidney development IEA --
GO:0001826 inner cell mass cell differentiation IEA --
GO:0007219 Notch signaling pathway IBA --
genes like me logo Genes that share ontologies with NLE1: view

No data available for Pathways by source and SIGNOR curated interactions for NLE1 Gene

Drugs & Compounds for NLE1 Gene

No Compound Related Data Available

Transcripts for NLE1 Gene

Unigene Clusters for NLE1 Gene

Notchless homolog 1 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLE1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP3: - -
SP5: - -

Relevant External Links for NLE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NLE1 Gene

mRNA differential expression in normal tissues according to GTEx for NLE1 Gene

This gene is overexpressed in Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for NLE1 Gene

This gene is overexpressed in Breast (21.0), Adipocyte (15.5), and Peripheral blood mononuclear cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NLE1 Gene

Protein tissue co-expression partners for NLE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NLE1 Gene:


SOURCE GeneReport for Unigene cluster for NLE1 Gene:


Evidence on tissue expression from TISSUES for NLE1 Gene

  • Nervous system(4.7)
  • Lung(4.3)
  • Pancreas(2.7)
  • Blood(2.2)
  • Intestine(2.2)
  • Stomach(2.2)
  • Skin(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with NLE1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLE1 Gene

Orthologs for NLE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NLE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NLE1 33 34
  • 99.52 (n)
(Bos Taurus)
Mammalia NLE1 33 34
  • 91.28 (n)
(Canis familiaris)
Mammalia NLE1 33 34
  • 91.13 (n)
(Rattus norvegicus)
Mammalia Nle1 33
  • 89.55 (n)
(Mus musculus)
Mammalia Nle1 33 16 34
  • 89.14 (n)
(Monodelphis domestica)
Mammalia NLE1 34
  • 84 (a)
(Gallus gallus)
Aves NLE1 33 34
  • 76.65 (n)
(Anolis carolinensis)
Reptilia NLE1 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nle1 33
  • 73.32 (n)
Str.11153 33
African clawed frog
(Xenopus laevis)
Amphibia nle-pending-prov 33
(Danio rerio)
Actinopterygii nle1 33 34
  • 73.32 (n)
wufc12b09 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002221 33
  • 60.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nle 33 34
  • 59.66 (n)
(Caenorhabditis elegans)
Secernentea W07E6.2 33 34
  • 58.21 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER263C 33
  • 56.15 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08547g 33
  • 52.62 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSA4 33 34
  • 50.73 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G52820 33
  • 54.43 (n)
(Oryza sativa)
Liliopsida Os10g0104500 33
  • 60.3 (n)
(Hordeum vulgare)
Liliopsida Hv.6600 33
(Triticum aestivum)
Liliopsida Ta.10544 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 66 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00794 33
  • 52.4 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC18.05c 33
  • 51.35 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13874 33
Species where no ortholog for NLE1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NLE1 Gene

Gene Tree for NLE1 (if available)
Gene Tree for NLE1 (if available)

Paralogs for NLE1 Gene

Paralogs for NLE1 Gene

(12) SIMAP similar genes for NLE1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NLE1: view

Variants for NLE1 Gene

Sequence variations from dbSNP and Humsavar for NLE1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs75635495 A breast cancer sample 35,136,371(+) TCCTT(G/T)GAGGT reference, missense
rs1000163855 -- 35,130,645(+) GCTCA(A/G)CCACT utr-variant-3-prime
rs1000190657 -- 35,141,190(+) CAGGA(A/G)CTGCA intron-variant
rs1000318372 -- 35,136,458(+) GTTCA(C/T)CCAGT reference, missense, utr-variant-5-prime
rs1000365527 -- 35,134,995(+) TGTAA(C/T)GAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLE1 Gene

Variant ID Type Subtype PubMed ID
nsv2036 CNV insertion 18451855
esv3892998 CNV loss 25118596
esv3410861 CNV insertion 20981092
esv3306040 CNV mobile element insertion 20981092

Variation tolerance for NLE1 Gene

Residual Variation Intolerance Score: 43.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.43; 71.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NLE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLE1 Gene

Disorders for NLE1 Gene

Relevant External Links for NLE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NLE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLE1 Gene

Publications for NLE1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 60
  4. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F … Valle G (Yeast (Chichester, England) 2001) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for NLE1 Gene

Sources for NLE1 Gene

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