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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NLE1 Gene

protein-coding GIFtS: 46
GCID: GC17M033458

notchless homolog 1 (Drosophila)

Explore 4 diseases affiliated with
NLE1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Notchless Homolog 1 (Drosophila)¹ ²
FLJ10458¹
Nle²
Notchless Gene Homolog²
Notchless Protein Homolog 1²

External Ids:	HGNC: 19889¹	Entrez Gene: 54475²	Ensembl: ENSG00000073536⁷	UniProtKB: Q9NVX2³

Export aliases for NLE1 gene to outside databases

Previous GC identifers: GC17M030472 GC17M029643

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for NLE1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NLE1 gene promoter:
CREB SREBP-1a p53 SREBP-1c deltaCREB Nkx2-5 SREBP-1b c-Ets-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NLE1 promoter sequence

Search SABiosciences Chromatin IP Primers for NLE1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NLE1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12

NLE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLE1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M033458: view genomic region (about GC identifiers)

Start:	33,455,772 bp from pter	End:	33,469,334 bp from pter
Size:	13,563 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NLE1_HUMAN, Q9NVX2 (See protein sequence)

Recommended Name: Notchless protein homolog 1

Size: 485 amino acids; 53320 Da

Subcellular location: Nucleus, nucleolus

Sequence caution: Sequence=BAD92348.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: O60868 Q59GJ8 Q9BU54

Alternative splicing: 2 isoforms: Q9NVX2-1 Q9NVX2-2

Explore the universe of human proteins at neXtProt for NLE1: NX_Q9NVX2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NVX2

NLE1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001014445.1 NP_060566.2

ENSEMBL proteins:

ENSP00000466588 ENSP00000413572 ENSP00000354075 ENSP00000466764 ENSP00000468339

ENSP00000465420

Human Recombinant Protein Products for NLE1:

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	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	nucleolus	IDA	--

NLE1 for ontologies About GeneDecksing

NLE1 Antibody Products:

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Assay Products for NLE1:

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	GenScript Custom Assay Services for NLE1
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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NLE1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR012972 NLE

IPR019775 WD40_repeat_CS

IPR001680 WD40_repeat

IPR020472 G-protein_beta_WD-40_rep

IPR001632 Gprotein_B

Graphical View of Domain Structure for InterPro Entry Q9NVX2

ProtoNet protein and cluster: Q9NVX2

1 Blocks protein family: IPB012972 NLE

UniProtKB/Swiss-Prot: NLE1_HUMAN, Q9NVX2

Similarity: Belongs to the NLE1/RSA4 family

Similarity: Contains 8 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for NLE1:

Decreased influenza A/WSN/33 r

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nle1):

cellular

embryogenesis

mortality/aging

NLE1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Nle1^tm1Cba for NLE1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NLE1

miRNA Products:		OriGene 3'-UTR Clone (see all 2): NLE1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NLE1
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate NLE1:
		hsa-miR-214 hsa-miR-133a hsa-miR-1827 hsa-miR-1207-5p hsa-miR-1825 hsa-miR-133b hsa-miR-761
		SwitchGear 3'UTR luciferase reporter plasmid: NLE1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NLE1 (see all 7) OriGene shRNA RFP: NLE1 OriGene siRNA: NLE1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against NLE1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NLE1
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NLE1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NLE1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NLE1
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		Sirion Biotech Customized stable knockdown cell line services for NLE1 Sirion Biotech Customized inducible knockdown cell line services for NLE1 Sirion Biotech Customized stable overexpressing cell line services for NLE1 Sirion Biotech Customized inducible overexpressing cell line services for NLE1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLE1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NLE1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/50 Interacting proteins for NLE1 (Q9NVX2³ ENSP00000413572⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 50)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNL3	Q9BVP2³, ENSP00000395772⁴	I2D: score=4 STRING: ENSP00000395772
MDN1	Q9NU22³, ENSP00000358400⁴	I2D: score=3 STRING: ENSP00000358400
SDAD1	Q9NVU7³, ENSP00000348596⁴	I2D: score=3 STRING: ENSP00000348596
GNL2	Q13823³, ENSP00000362153⁴	I2D: score=2 STRING: ENSP00000362153
GTPBP4	Q9BZE4³, ENSP00000354040⁴	I2D: score=2 STRING: ENSP00000354040

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001826	inner cell mass cell differentiation	IEA	--
GO:0007219	Notch signaling pathway	IEA	--

NLE1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NLE1
Search CenterWatch for drugs/clinical trials and news about NLE1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NLE1 gene (2 alternative transcripts):

NM_001014445.1 NM_018096.3

Unigene Cluster for NLE1:

Notchless homolog 1 (Drosophila)

Hs.85570 [show with all ESTs]

Unigene Representative Sequence: AB209111

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000586869 ENST00000442241(uc002hiy.1) ENST00000360831(uc002hiz.1)

ENST00000588019 ENST00000589367 ENST00000593176 ENST00000588642

miRNA Products:		OriGene 3'-UTR Clone (see all 2): NLE1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NLE1
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate NLE1:
		hsa-miR-214 hsa-miR-133a hsa-miR-1827 hsa-miR-1207-5p hsa-miR-1825 hsa-miR-133b hsa-miR-761
		SwitchGear 3'UTR luciferase reporter plasmid: NLE1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NLE1 (see all 7) OriGene shRNA RFP: NLE1 OriGene siRNA: NLE1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NLE1
		Sirion Biotech Custom design and validation of potent shRNA sequences against NLE1

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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NLE1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NLE1
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Additional cDNA sequence:

AB209111.1 AJ005257.1 AK001320.1 AK303253.1 AK304508.1 BC002884.2 BC012075.1

10 DOTS entries:

DT.100802363 DT.315063 DT.100802351 DT.91758027 DT.100802350 DT.40213257 DT.100802355 DT.442030

DT.120989953 DT.92026432

24/256 AceView cDNA sequences (see all 256):

BM464367 AJ005257 CR590297 BU185499 BQ689820 R50215 CR623995 BU174112

BQ878593 BC012075 BQ685587 BM556854 CR606426 CR624634 BQ684998 CR615350

AI142595 BU623747 BC002884 BX338169 NM_018096 BU145156 BI861602 AA626850

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for NLE1 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11	^	12	^	13
SP1:									-																				-
SP2:
SP3:							-		-
SP4:
SP5:									-						-

ECgene alternative splicing isoforms for NLE1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NLE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCTGCCCG

About this image
See NLE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NLE1

SOURCE GeneReport for Unigene cluster: Hs.85570
SABiosciences Custom PCR Arrays for NLE1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NLE1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLE1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NLE1 gene from 9/37 species (see all 37) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NLE1¹	notchless homolog 1 (Drosophila)	76.89(n) 84.57(a)		417613 XM_415857.3 XP_415857.2
lizard (Anolis carolinensis)	Reptilia	NLE1⁶	--	74(a)	1 ↔ 1	GL344046.1(11479-12545)
African clawed frog (Xenopus laevis)	Amphibia	nle-pending-prov²	Notchless gene homolog (Drosophila)	74.49(n)		BC044710.1
zebrafish (Danio rerio)	Actinopterygii	wufc12b09²	Transcribed sequence with moderate similarity to protein refNP_060566.1 (H.sapiens) hypothetical protein similar to beta-transducin family [Homo sapiens] less	81.16(n)		BQ259555.1
fruit fly (Drosophila melanogaster)	Insecta	Nle¹	Notchless	59.59(n) 59.02(a)		33234 NM_057946.3 NP_477294.2
worm (Caenorhabditis elegans)	Secernentea	W07E6.2¹	Protein W07E6.2	58.06(n) 59.96(a)		173439 NM_061344.3 NP_493745.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RSA4¹	Rsa4p	50.95(n) 49.47(a)		850435 NP_009997.2
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G52820¹	Notchless protein-like protein	54.73(n) 56.7(a)		835359 NM_124660.3 NP_200094.1
rice (Oryza sativa)	Liliopsida	AK112063.1²	--	71.04(n)		AK112063.1

ENSEMBL Gene Tree for NLE1 (if available)
TreeFam Gene Tree for NLE1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NLE1 gene

AAMP²

12 SIMAP similar genes for NLE1 using alignment to 4 protein entries: NLE1_HUMAN (see all proteins):

GALK2 C12orf23 CNOT2 BUB1B GNB1 UTY

POC1B WSB1 PF20 WDR38 WDR83 WDR5

NLE1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117054478^1,2	F	--	33457933(+)	`GTGCTC/GTAAGA`	3	--	int¹ ds500¹		1		EA	120
rs182846360^1,2		--	33457969(+)	`TACAGA/GAATAG`	3	--	int¹ ds500¹		0	--	--	--	--
rs147288565^1,2		--	33458030(+)	`CTGGAC/TGGAGG`	3	--	int¹ ds500¹		0	--	--	--	--
rs142195961^1,2	C	--	33458089(+)	`CCCAG-/CTCTTTC`	3	--	int¹ ds500¹		0	--	--	--	--
rs148769411^1,2		--	33458116(+)	`GGCATA/GGGCTA`	3	--	ds500¹ int¹		0	--	--	--	--
rs77876240^1,2	F	--	33458216(+)	`GCTGGC/TACCAA`	3	--	int¹ ds500¹		2		WA EA	238
rs77842244^1,2	C,F	--	33458219(+)	`GGCACC/TAAGGA`	3	--	ds500¹ int¹		2		WA EA	238
rs142425009^1,2		--	33458243(+)	`TAGTTC/TTGTTC`	3	--	ds500¹ int¹		0	--	--	--	--
rs150740978^1,2		--	33458249(+)	`TGTTCA/GCTTCT`	3	--	ds500¹ int¹		0	--	--	--	--
rs139107769^1,2		--	33458315(+)	`GACGCA/GCAAAA`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NLE1 (33455772 - 33469334 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NLE1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NLE1

DNA2.0 Custom Variant and Variant Library Synthesis for NLE1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NLE1 for disorders About GeneDecksing

4 diseases for NLE1: About MalaCards

heart block congenital heart block lupus erythematosus malaria

Export disorders for NLE1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NLE1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with NLE1)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Functional proteomic analysis of human nucleolus. (PubMed id 12429849)^{1, 2} Scherl A.... Diaz J.-J. (2002)
Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)^{1, 2} Stanchi F.... Valle G. (2001)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)¹ Tsai Y.C....Cristea I.M. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54475	HGNC: 19889	AceView: FLJ10458	Ensembl:ENSG00000073536	euGenes: HUgn54475
ECgene: NLE1	H-InvDB: NLE1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NLE1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NLE1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NLE1 gene:
Search GeneIP for patents involving NLE1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NLE1
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Search for Antibodies & Assays

	Regulatory tfbs in NLE1 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for NLE1

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLE1

	SwitchGear 3'UTR luciferase reporter plasmids for NLE1
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Search ThermoFisher Antibodies for NLE1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLE1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NLE1

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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NLE1 Gene

notchless homolog 1 (Drosophila)

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NLE1 Gene

notchless homolog 1 (Drosophila)

Aliasesfor NLE1 gene

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Genomic Viewsfor NLE1 gene

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Protein Domains /Familiesfor NLE1 gene

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Genome Databases showing NLE1 gene

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Specialized Databases showing NLE1 gene

Intellectual Propertyfor NLE1 gene

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Summaries
for NLE1 gene

Genomic Views
for NLE1 gene

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for NLE1 gene

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for NLE1 gene

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for NLE1 gene

Pathways & Interactions
for NLE1 gene

Drugs & Compounds
for NLE1 gene

Transcripts
for NLE1 gene

Expression
for NLE1 gene

Orthologs
for NLE1 gene

Paralogs
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Genomic Variants
for NLE1 gene

Disorders / Diseases
for NLE1 gene

Publications
for NLE1 gene

Intellectual Property
for NLE1 gene

Products
for NLE1 gene