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Aliases for NLE1 Gene

Aliases for NLE1 Gene

  • Notchless Homolog 1 (Drosophila) 2 3 5
  • Notchless Gene Homolog 2 3
  • (Drosophila) 2
  • Nle 3

External Ids for NLE1 Gene

Previous GeneCards Identifiers for NLE1 Gene

  • GC17M030472
  • GC17M033458
  • GC17M029643

Summaries for NLE1 Gene

GeneCards Summary for NLE1 Gene

NLE1 (Notchless Homolog 1 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is WSB1.

UniProtKB/Swiss-Prot for NLE1 Gene

  • Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).

Gene Wiki entry for NLE1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLE1 Gene

Genomics for NLE1 Gene

Regulatory Elements for NLE1 Gene

Enhancers for NLE1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NLE1 on UCSC Golden Path with GeneCards custom track

Promoters for NLE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NLE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NLE1 Gene

35,128,753 bp from pter
35,142,315 bp from pter
13,563 bases
Minus strand

Genomic View for NLE1 Gene

Genes around NLE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLE1 Gene

Proteins for NLE1 Gene

  • Protein details for NLE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Notchless protein homolog 1
    Protein Accession:
    Secondary Accessions:
    • O60868
    • Q59GJ8
    • Q9BU54

    Protein attributes for NLE1 Gene

    485 amino acids
    Molecular mass:
    53320 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD92348.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NLE1 Gene


neXtProt entry for NLE1 Gene

Proteomics data for NLE1 Gene at MOPED

Post-translational modifications for NLE1 Gene

  • Ubiquitination at Lys 224 and Lys 326
  • Modification sites at PhosphoSitePlus

Other Protein References for NLE1 Gene

No data available for DME Specific Peptides for NLE1 Gene

Domains & Families for NLE1 Gene

Gene Families for NLE1 Gene

Suggested Antigen Peptide Sequences for NLE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NLE1/RSA4 family.
  • Contains 8 WD repeats.
  • Belongs to the NLE1/RSA4 family.
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with NLE1: view

Function for NLE1 Gene

Molecular function for NLE1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).
genes like me logo Genes that share phenotypes with NLE1: view

Animal Models for NLE1 Gene

MGI Knock Outs for NLE1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NLE1 Gene

Localization for NLE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLE1 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for NLE1 Gene COMPARTMENTS Subcellular localization image for NLE1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
plasma membrane 2
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NLE1 Gene

Pathways & Interactions for NLE1 Gene

SuperPathways for NLE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001756 somitogenesis IEA --
GO:0001822 kidney development IEA --
GO:0042273 ribosomal large subunit biogenesis IEA --
GO:0048705 skeletal system morphogenesis IEA --
GO:0061484 hematopoietic stem cell homeostasis IEA --
genes like me logo Genes that share ontologies with NLE1: view

No data available for Pathways by source and SIGNOR curated interactions for NLE1 Gene

Drugs & Compounds for NLE1 Gene

No Compound Related Data Available

Transcripts for NLE1 Gene

Unigene Clusters for NLE1 Gene

Notchless homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NLE1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP3: - -
SP5: - -

Relevant External Links for NLE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLE1 Gene

mRNA expression in normal human tissues for NLE1 Gene

mRNA differential expression in normal tissues according to GTEx for NLE1 Gene

This gene is overexpressed in Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for NLE1 Gene

This gene is overexpressed in Breast (21.0), Adipocyte (15.5), and Peripheral blood mononuclear cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NLE1 Gene

SOURCE GeneReport for Unigene cluster for NLE1 Gene Hs.85570

genes like me logo Genes that share expression patterns with NLE1: view

Protein tissue co-expression partners for NLE1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NLE1 Gene

Orthologs for NLE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NLE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NLE1 35
  • 91.28 (n)
  • 95.99 (a)
NLE1 36
  • 95 (a)
(Canis familiaris)
Mammalia NLE1 35
  • 91.13 (n)
  • 95.64 (a)
NLE1 36
  • 96 (a)
(Mus musculus)
Mammalia Nle1 35
  • 89.14 (n)
  • 95.26 (a)
Nle1 16
Nle1 36
  • 95 (a)
(Pan troglodytes)
Mammalia NLE1 35
  • 99.52 (n)
  • 99.38 (a)
NLE1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nle1 35
  • 89.55 (n)
  • 95.26 (a)
(Monodelphis domestica)
Mammalia NLE1 36
  • 84 (a)
(Gallus gallus)
Aves NLE1 35
  • 76.65 (n)
  • 84.2 (a)
NLE1 36
  • 82 (a)
(Anolis carolinensis)
Reptilia NLE1 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nle1 35
  • 73.32 (n)
  • 82.14 (a)
Str.11153 35
African clawed frog
(Xenopus laevis)
Amphibia nle-pending-prov 35
(Danio rerio)
Actinopterygii nle1 35
  • 73.32 (n)
  • 77.73 (a)
wufc12b09 35
nle1 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002221 35
  • 60.82 (n)
  • 57.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nle 35
  • 59.66 (n)
  • 59.02 (a)
Nle 36
  • 56 (a)
(Caenorhabditis elegans)
Secernentea W07E6.2 35
  • 58.21 (n)
  • 60.39 (a)
W07E6.2 36
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER263C 35
  • 56.15 (n)
  • 50.32 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08547g 35
  • 52.62 (n)
  • 50.75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSA4 35
  • 50.73 (n)
  • 49.27 (a)
RSA4 36
  • 45 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G52820 35
  • 54.43 (n)
  • 55.72 (a)
(Hordeum vulgare)
Liliopsida Hv.6600 35
(Oryza sativa)
Liliopsida Os10g0104500 35
  • 60.3 (n)
  • 59.87 (a)
(Triticum aestivum)
Liliopsida Ta.10544 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13874 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00794 35
  • 52.4 (n)
  • 45.97 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC18.05c 35
  • 51.35 (n)
  • 49.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
Species with no ortholog for NLE1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NLE1 Gene

Gene Tree for NLE1 (if available)
Gene Tree for NLE1 (if available)

Paralogs for NLE1 Gene

Paralogs for NLE1 Gene

(12) SIMAP similar genes for NLE1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NLE1: view

Variants for NLE1 Gene

Sequence variations from dbSNP and Humsavar for NLE1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_035886 A breast cancer sample
rs2306513 - 35,133,497(+) CAGGT(A/G)CCTGG reference, missense
rs2306512 - 35,133,412(+) TGTCA(C/T)TGCTG reference, missense
rs1471615 - 35,142,260(-) CAGTG(C/G)CGGTG upstream-variant-2KB, reference, missense
rs7215209 - 35,137,845(+) GCTTC(C/T)TGCCA reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NLE1 Gene

Variant ID Type Subtype PubMed ID
nsv2036 CNV Insertion 18451855
esv270317 CNV Insertion 20981092

Variation tolerance for NLE1 Gene

Residual Variation Intolerance Score: 43.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.43; 71.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NLE1 Gene

Disorders for NLE1 Gene

Relevant External Links for NLE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NLE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLE1 Gene

Publications for NLE1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The Crystal Structure of the Ubiquitin-like Domain of Ribosome Assembly Factor Ytm1 and Characterization of Its Interaction with the AAA-ATPase Midasin. (PMID: 26601951) Romes E.M. … Stanley R.E. (J. Biol. Chem. 2016) 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for NLE1 Gene

Sources for NLE1 Gene