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Aliases for NLE1 Gene

Aliases for NLE1 Gene

  • Notchless Homolog 1 (Drosophila) 2 3
  • Notchless Gene Homolog 2 3
  • Notchless Protein Homolog 1 3
  • (Drosophila) 2
  • Nle 3

External Ids for NLE1 Gene

Summaries for NLE1 Gene

GeneCards Summary for NLE1 Gene

NLE1 (Notchless Homolog 1 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is ATG16L1.

UniProtKB/Swiss-Prot for NLE1 Gene

  • Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).

Gene Wiki entry for NLE1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLE1 Gene

Genomics for NLE1 Gene

Genomic Location for NLE1 Gene

Start:
35,128,753 bp from pter
End:
35,142,315 bp from pter
Size:
13,563 bases
Orientation:
Minus strand

Genomic View for NLE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NLE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLE1 Gene

Regulatory Elements for NLE1 Gene

Proteins for NLE1 Gene

  • Protein details for NLE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVX2-NLE1_HUMAN
    Recommended name:
    Notchless protein homolog 1
    Protein Accession:
    Q9NVX2
    Secondary Accessions:
    • O60868
    • Q59GJ8
    • Q9BU54

    Protein attributes for NLE1 Gene

    Size:
    485 amino acids
    Molecular mass:
    53320 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92348.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NLE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NLE1 Gene

Proteomics data for NLE1 Gene at MOPED

Post-translational modifications for NLE1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys224 and Lys326

Other Protein References for NLE1 Gene

No data available for DME Specific Peptides for NLE1 Gene

Domains for NLE1 Gene

Gene Families for NLE1 Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

NLE1_HUMAN
Family:
  • Belongs to the NLE1/RSA4 family.:
    • Q9NVX2
Similarity:
  • Contains 8 WD repeats.:
    • Q9NVX2
genes like me logo Genes that share domains with NLE1: view

Function for NLE1 Gene

Molecular function for NLE1 Gene

UniProtKB/Swiss-Prot Function: Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).

Gene Ontology (GO) - Molecular Function for NLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NLE1: view
genes like me logo Genes that share phenotypes with NLE1: view

Animal Models for NLE1 Gene

MGI Knock Outs for NLE1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NLE1 Gene

Localization for NLE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLE1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NLE1 Gene COMPARTMENTS Subcellular localization image for NLE1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with NLE1: view

Pathways for NLE1 Gene

SuperPathways for NLE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001826 inner cell mass cell differentiation IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0042273 ribosomal large subunit biogenesis IEA --
GO:0045930 negative regulation of mitotic cell cycle IEA --
GO:0061484 hematopoietic stem cell homeostasis IEA --
genes like me logo Genes that share ontologies with NLE1: view

No data available for Pathways by source for NLE1 Gene

Transcripts for NLE1 Gene

Unigene Clusters for NLE1 Gene

Notchless homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NLE1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2:
SP3: - -
SP4:
SP5: - -

Relevant External Links for NLE1 Gene

GeneLoc Exon Structure for
NLE1
ECgene alternative splicing isoforms for
NLE1

Expression for NLE1 Gene

mRNA expression in normal human tissues for NLE1 Gene

mRNA differential expression in normal tissues according to GTEx for NLE1 Gene

This gene is overexpressed in Pancreas (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NLE1 Gene

SOURCE GeneReport for Unigene cluster for NLE1 Gene Hs.85570

genes like me logo Genes that share expressions with NLE1: view

Orthologs for NLE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NLE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLE1 36
  • 99.52 (n)
  • 99.38 (a)
NLE1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NLE1 36
  • 91.28 (n)
  • 95.99 (a)
NLE1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NLE1 36
  • 91.13 (n)
  • 95.64 (a)
NLE1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nle1 36
  • 89.14 (n)
  • 95.26 (a)
Nle1 16
Nle1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NLE1 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nle1 36
  • 89.55 (n)
  • 95.26 (a)
chicken
(Gallus gallus)
Aves NLE1 36
  • 76.65 (n)
  • 84.2 (a)
NLE1 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NLE1 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia nle-pending-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nle1 36
  • 73.32 (n)
  • 82.14 (a)
Str.11153 36
zebrafish
(Danio rerio)
Actinopterygii nle1 36
  • 73.32 (n)
  • 77.73 (a)
nle1 37
  • 78 (a)
OneToOne
wufc12b09 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002221 36
  • 60.82 (n)
  • 57.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nle 36
  • 59.66 (n)
  • 59.02 (a)
Nle 37
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea W07E6.2 36
  • 58.21 (n)
  • 60.39 (a)
W07E6.2 37
  • 58 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER263C 36
  • 56.15 (n)
  • 50.32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSA4 36
  • 50.73 (n)
  • 49.27 (a)
RSA4 37
  • 45 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08547g 36
  • 52.62 (n)
  • 50.75 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G52820 36
  • 54.43 (n)
  • 55.72 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6600 36
rice
(Oryza sativa)
Liliopsida Os10g0104500 36
  • 60.3 (n)
  • 59.87 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.10544 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00794 36
  • 52.4 (n)
  • 45.97 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC18.05c 36
  • 51.35 (n)
  • 49.45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13874 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 66 (a)
OneToOne
Species with no ortholog for NLE1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NLE1 Gene

ENSEMBL:
Gene Tree for NLE1 (if available)
TreeFam:
Gene Tree for NLE1 (if available)

Paralogs for NLE1 Gene

Selected SIMAP similar genes for NLE1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NLE1: view

Variants for NLE1 Gene

Sequence variations from dbSNP and Humsavar for NLE1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1471615 - 35,142,260(-) CAGTG(C/G)CGGTG upstream-variant-2KB, reference, missense
rs2306509 -- 35,133,141(+) CTGTG(C/T)ATGCC intron-variant, downstream-variant-500B
rs2306510 -- 35,133,156(+) ACCAC(C/T)TCCCC intron-variant, downstream-variant-500B
rs2306511 -- 35,133,348(+) TCCGC(A/G)TGGCC reference, synonymous-codon
rs2306512 - 35,133,412(+) TGTCA(C/T)TGCTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for NLE1 Gene

Variant ID Type Subtype PubMed ID
nsv2036 CNV Insertion 18451855
esv270317 CNV Insertion 20981092

Relevant External Links for NLE1 Gene

HapMap Linkage Disequilibrium report
NLE1

Disorders for NLE1 Gene

No disorders were found for NLE1 Gene.

No data available for UniProtKB/Swiss-Prot for NLE1 Gene

Publications for NLE1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F. … Valle G. (Yeast 2001) 3 4
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for NLE1 Gene

Sources for NLE1 Gene

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