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NLE1 Gene

protein-coding   GIFtS: 50
GCID: GC17M033458

Notchless Homolog 1 (Drosophila)

  Search for NLE1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Notchless Homolog 1 (Drosophila)1 2
Notchless Gene Homolog1 2
(Drosophila)1
Nle2
Notchless Protein Homolog 12

External Ids:    HGNC: 198891   Entrez Gene: 544752   Ensembl: ENSG000000735367   UniProtKB: Q9NVX23   

Export aliases for NLE1 gene to outside databases

Previous GC identifers: GC17M030472 GC17M029643


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NLE1 Gene:
NLE1 (notchless homolog 1 (Drosophila)) is a protein-coding gene. An important paralog of this gene is WDR83.

UniProtKB/Swiss-Prot: NLE1_HUMAN, Q9NVX2
Function: Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and
several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for
inner mass cell survival (By similarity)

Gene Wiki entry for NLE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NLE1 gene promoter:
         CREB   SREBP-1a   p53   SREBP-1c   deltaCREB   Nkx2-5   SREBP-1b   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNLE1 promoter sequence
   Search Chromatin IP Primers for NLE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NLE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

NLE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NLE1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M033458:  view genomic region     (about GC identifiers)

Start:
33,455,772 bp from pter      End:
33,469,334 bp from pter
Size:
13,563 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NLE1_HUMAN, Q9NVX2 (See protein sequence)
Recommended Name: Notchless protein homolog 1  
Size: 485 amino acids; 53320 Da
Sequence caution: Sequence=BAD92348.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O60868 Q59GJ8 Q9BU54
Alternative splicing: 2 isoforms:  Q9NVX2-1   Q9NVX2-2   

Explore the universe of human proteins at neXtProt for NLE1: NX_Q9NVX2

Explore proteomics data for NLE1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys224, Lys326
  • Modification sites at PhosphoSitePlus

  • See NLE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001014445.1  NP_060566.2  

    ENSEMBL proteins: 
     ENSP00000466588   ENSP00000413572   ENSP00000354075   ENSP00000466764   ENSP00000468339  
     ENSP00000465420  

    NLE1 Human Recombinant Protein Products:

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    Novus Biologicals NLE1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NLE1 

    NLE1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for NLE1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR012972 NLE
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001632 Gprotein_B

    Graphical View of Domain Structure for InterPro Entry Q9NVX2

    ProtoNet protein and cluster: Q9NVX2

    1 Blocks protein domain: IPB012972 NLE

    UniProtKB/Swiss-Prot: NLE1_HUMAN, Q9NVX2
    Similarity: Belongs to the NLE1/RSA4 family
    Similarity: Contains 8 WD repeats


    Find genes that share domains with NLE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NLE1_HUMAN, Q9NVX2
    Function: Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and
    several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for
    inner mass cell survival (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with NLE1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NLE1:
     Decreased influenza A/WSN/33 r 

         6 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Nle1):
     cellular  digestive/alimentary  embryogenesis  hematopoietic system  immune system 
     mortality/aging 

    Find genes that share phenotypes with NLE1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nle1tm1Cba for NLE1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NLE1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NLE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NLE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NLE1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NLE1:
    hsa-mir-92a-3p (MIRT049402), hsa-mir-30c-5p (MIRT048020), hsa-let-7b-5p (MIRT032412), hsa-mir-98-5p (MIRT027611), hsa-mir-222-3p (MIRT046828), hsa-mir-16-5p (MIRT031827), hsa-mir-375 (MIRT019953), hsa-mir-484 (MIRT042382)

    Block miRNA regulation of human, mouse, rat NLE1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate NLE1:
    hsa-miR-214 hsa-miR-133a hsa-miR-1827 hsa-miR-1207-5p hsa-miR-1825 hsa-miR-133b hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidNLE1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NLE1
    Predesigned siRNA for gene silencing in human, mouse, rat NLE1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): NLE1 (NM_018096)
    Sino Biological Human cDNA Clone for NLE1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NLE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLE1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NLE1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NLE1_HUMAN, Q9NVX2: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    plasma membrane2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with NLE1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NLE1
    Interactions:

        Search GeneGlobe Interaction Network for NLE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NLE1 (Q9NVX23 ENSP000004135724) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNL3Q9BVP23, ENSP000003957724I2D: score=4 STRING: ENSP00000395772
    MDN1Q9NU223, ENSP000003584004I2D: score=3 STRING: ENSP00000358400
    SDAD1Q9NVU73, ENSP000003485964I2D: score=3 STRING: ENSP00000348596
    GNL2Q138233, ENSP000003621534I2D: score=2 STRING: ENSP00000362153
    GTPBP4Q9BZE43, ENSP000003540404I2D: score=2 STRING: ENSP00000354040
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001826inner cell mass cell differentiation IEA--
    GO:0007219Notch signaling pathway IEA--
    GO:0090263positive regulation of canonical Wnt signaling pathway IEA--
    GO:2001268negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA--

    Find genes that share ontologies with NLE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NLE1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NLE1 gene (2 alternative transcripts): 
    NM_001014445.2  NM_018096.4  

    Unigene Cluster for NLE1:

    Notchless homolog 1 (Drosophila)
    Hs.85570  [show with all ESTs]
    Unigene Representative Sequence: AB209111
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586869 ENST00000442241(uc002hiy.1) ENST00000360831(uc002hiz.1)
    ENST00000588019 ENST00000589367 ENST00000593176 ENST00000588642
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NLE1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate NLE1:
    hsa-miR-214 hsa-miR-133a hsa-miR-1827 hsa-miR-1207-5p hsa-miR-1825 hsa-miR-133b hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidNLE1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NLE1
    Predesigned siRNA for gene silencing in human, mouse, rat NLE1
    Clone
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    OriGene clones in human, mouse for NLE1 (see all 13)
    OriGene ORF clones in mouse, rat for NLE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NLE1 (NM_018096)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NLE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NLE1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NLE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NLE1
      QuantiTect SYBR Green Assays in human, mouse, rat NLE1
      QuantiFast Probe-based Assays in human, mouse, rat NLE1

    Additional mRNA sequence: 

    AB209111.1 AJ005257.1 AK001320.1 AK303253.1 AK304508.1 BC002884.2 BC012075.1 

    10 DOTS entries:

    DT.100802363  DT.315063  DT.100802351  DT.91758027  DT.100802350  DT.40213257  DT.100802355  DT.442030 
    DT.120989953  DT.92026432 

    Selected AceView cDNA sequences (see all 256):

    BQ689702 BI861602 BQ691884 BF510528 CR623995 BQ685631 BM556854 AI337064 
    R50215 BU185499 BE257540 CR621507 AJ005257 AA626850 BM464367 BQ691865 
    BU623747 BQ690257 AA337225 D31000 NM_018096 BU687186 AI687529 CA441335 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NLE1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                          -                                                           -                     
    SP2:                                                                                                            
    SP3:                    -     -                                                                                 
    SP4:                                                                                                            
    SP5:                          -                 -                                                               


    ECgene alternative splicing isoforms for NLE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NLE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCTGCCCG
    NLE1 Expression
    About this image

    NLE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NLE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.85570
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NLE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NLE1 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nle11 , 5 notchless homolog 1 (Drosophila)1, 5 89.14(n)1
    95.26(a)1
      11 (50.30 cM)5
    2170111  NM_145431.21  NP_663406.21 
     829007685 
    chicken
    (Gallus gallus)
    Aves NLE11 notchless homolog 1 (Drosophila) 76.65(n)
    84.2(a)
      417613  XM_415857.4  XP_415857.3 
    lizard
    (Anolis carolinensis)
    Reptilia NLE16
    notchless homolog 1 (Drosophila)
    74(a)
    1 ↔ 1
    GL344046.1(11479-12545)
    African clawed frog
    (Xenopus laevis)
    Amphibia nle-pending-prov2 Notchless gene homolog (Drosophila) 74.49(n)    BC044710.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc12b092 Transcribed sequence with moderate similarity to protein more 81.16(n)    BQ259555.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nle1 Notchless 59.66(n)
    59.02(a)
      33234  NM_057946.4  NP_477294.2 
    worm
    (Caenorhabditis elegans)
    Secernentea W07E6.21 W07E6.2 58.21(n)
    60.39(a)
      173439  NM_061344.4  NP_493745.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSA41 RSA4 50.73(n)
    49.27(a)
      850435   NP_009997.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G528201 AT5G52820 54.43(n)
    55.72(a)
      835359  NM_124660.3  NP_200094.1 
    rice
    (Oryza sativa)
    Liliopsida AK112063.12   -- 71.04(n)    AK112063.1 


    ENSEMBL Gene Tree for NLE1 (if available)
    TreeFam Gene Tree for NLE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NLE1 gene
    WDR832  POC1B2  WDR52  ATG16L12  SNRNP402  WDR5B2  PAFAH1B12  SMU12  
    DAW12  WDR382  ATG16L22  POC1A2  
    12 SIMAP similar genes for NLE1 using alignment to 4 protein entries:     NLE1_HUMAN (see all proteins):
    GALK2    C12orf23    CNOT2    BUB1B    GNB1    UTY
    POC1B    ECD    WSB1    PF20    WDR38    WDR83

    Find genes that share paralogs with NLE1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NLE1 (see all 361)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358864
    A breast cancer sample4--see VAR_0358862 Q K mis40--------
    rs1391077691,2
    --33458315(+) GACGCA/GCAAAA 2 -- int10--------
    rs2016490831,2
    --33458349(+) GGAGG-/GCTGTAAG 2 -- cds10--------
    rs1998480311,2
    --33458350(+) GAGGG-/CTTTAAGA 2 -- cds10--------
    rs1115314761,2
    C,F--33458468(+) AGGCAG/CGGTAC 2 -- ut312Minor allele frequency- C:0.05NA 122
    rs1147648681,2
    C,F--33458675(+) CAGTGC/GTTGGT 2 -- ut311Minor allele frequency- G:0.03WA 118
    rs792491121,2
    C,F--33458724(+) GAGGCA/GTCCCC 2 -- ut311Minor allele frequency- G:0.12EA 120
    rs779901471,2
    C--33458743(+) GGCTGA/GCCAGC 2 -- ut310--------
    rs1439732391,2
    --33458813(+) AGTGCA/GATGGA 2 -- ut310--------
    rs1871296141,2
    --33458878(+) GTGGAA/CAACAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NLE1 (33455772 - 33469334 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NLE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270317CNV Insertion20981092
    nsv2036CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NLE1
    DNA2.0 Custom Variant and Variant Library Synthesis for NLE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NLE1 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with NLE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    4. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)1, 2 Stanchi F.... Valle G. (Yeast 2001)
    5. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54475 HGNC: 19889 AceView: FLJ10458 Ensembl:ENSG00000073536 euGenes: HUgn54475
    ECgene: NLE1 H-InvDB: NLE1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NLE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NLE1 gene:
    Search GeneIP for patents involving NLE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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