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Aliases for NKX6-3 Gene

Aliases for NKX6-3 Gene

  • NK6 Homeobox 3 2 3
  • NKX6.3 3 6
  • NK6 Transcription Factor Related, Locus 3 (Drosophila) 2
  • NK6 Transcription Factor Related, Locus 3 3
  • Homeobox Protein Nkx-6.3 3

External Ids for NKX6-3 Gene

Summaries for NKX6-3 Gene

Entrez Gene Summary for NKX6-3 Gene

  • The NKX family of homeodomain proteins controls numerous developmental processes. Members of the NKX6 subfamily, including NKX6-3, are involved in development of the central nervous system (CNS), gastrointestinal tract, and pancreas (Alanentalo et al., 2006 [PubMed 16326147]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NKX6-3 Gene

NKX6-3 (NK6 Homeobox 3) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is NKX2-5.

UniProtKB/Swiss-Prot for NKX6-3 Gene

  • Putative transcription factor, which may be involved in patterning of central nervous system and pancreas.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKX6-3 Gene

Genomics for NKX6-3 Gene

Genomic Location for NKX6-3 Gene

Start:
41,645,178 bp from pter
End:
41,650,669 bp from pter
Size:
5,492 bases
Orientation:
Minus strand

Genomic View for NKX6-3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NKX6-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKX6-3 Gene

Regulatory Elements for NKX6-3 Gene

Proteins for NKX6-3 Gene

  • Protein details for NKX6-3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJ46-NKX63_HUMAN
    Recommended name:
    Homeobox protein Nkx-6.3
    Protein Accession:
    A6NJ46
    Secondary Accessions:
    • Q96LR0

    Protein attributes for NKX6-3 Gene

    Size:
    265 amino acids
    Molecular mass:
    28948 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NKX6-3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKX6-3 Gene

Proteomics data for NKX6-3 Gene at MOPED

Post-translational modifications for NKX6-3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKX6-3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKX6-3 Gene

Domains for NKX6-3 Gene

Gene Families for NKX6-3 Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Protein Domains for NKX6-3 Gene

Suggested Antigen Peptide Sequences for NKX6-3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NJ46

UniProtKB/Swiss-Prot:

NKX63_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • A6NJ46
genes like me logo Genes that share domains with NKX6-3: view

Function for NKX6-3 Gene

Molecular function for NKX6-3 Gene

UniProtKB/Swiss-Prot Function: Putative transcription factor, which may be involved in patterning of central nervous system and pancreas.

Gene Ontology (GO) - Molecular Function for NKX6-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NKX6-3: view

Phenotypes for NKX6-3 Gene

genes like me logo Genes that share phenotypes with NKX6-3: view

Animal Models for NKX6-3 Gene

MGI Knock Outs for NKX6-3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NKX6-3 Gene

Localization for NKX6-3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKX6-3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKX6-3 Gene COMPARTMENTS Subcellular localization image for NKX6-3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for NKX6-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NKX6-3: view

Pathways for NKX6-3 Gene

SuperPathways for NKX6-3 Gene

No Data Available

Interacting Proteins for NKX6-3 Gene

Gene Ontology (GO) - Biological Process for NKX6-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001709 cell fate determination IEA --
GO:0002067 glandular epithelial cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030857 negative regulation of epithelial cell differentiation IEA --
genes like me logo Genes that share ontologies with NKX6-3: view

No data available for Pathways by source for NKX6-3 Gene

Transcripts for NKX6-3 Gene

mRNA/cDNA for NKX6-3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKX6-3 Gene

NK6 homeobox 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKX6-3 Gene

No ASD Table

Relevant External Links for NKX6-3 Gene

GeneLoc Exon Structure for
NKX6-3
ECgene alternative splicing isoforms for
NKX6-3

Expression for NKX6-3 Gene

mRNA expression in normal human tissues for NKX6-3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKX6-3 Gene

This gene is overexpressed in Brain - Cerebellum (15.7), Brain - Cerebellar Hemisphere (15.0), and Stomach (5.4).

SOURCE GeneReport for Unigene cluster for NKX6-3 Gene Hs.647132

genes like me logo Genes that share expressions with NKX6-3: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for NKX6-3 Gene

Orthologs for NKX6-3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKX6-3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKX6-3 36
  • 37 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NKX6-3 36
  • 35 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKX6-3 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkx6-3 16
Nkx6-3 36
  • 36 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NKX6-3 36
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NKX6-3 36
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKX6-3 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NKX6-3 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nkx6.3 36
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NK7.1 36
  • 6 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 10 (a)
OneToMany
Species with no ortholog for NKX6-3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKX6-3 Gene

ENSEMBL:
Gene Tree for NKX6-3 (if available)
TreeFam:
Gene Tree for NKX6-3 (if available)

Paralogs for NKX6-3 Gene

Selected SIMAP similar genes for NKX6-3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKX6-3: view

Variants for NKX6-3 Gene

Sequence variations from dbSNP and Humsavar for NKX6-3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs693350 -- 41,650,855(-) AATGG(A/G)CCGTA upstream-variant-2KB
rs755162 -- 41,646,208(+) CTGTG(A/C)CTCCC downstream-variant-500B
rs3063733 -- 41,646,336(+) AAAGA(-/AAGA)CTCAG utr-variant-3-prime, downstream-variant-500B
rs4736819 -- 41,652,396(+) GGTTC(C/T)CGGTG upstream-variant-2KB
rs4736998 -- 41,648,454(+) CTGCC(C/G/T)TAGTG upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKX6-3 Gene

Variant ID Type Subtype PubMed ID
nsv831299 CNV Loss 17160897

Relevant External Links for NKX6-3 Gene

HapMap Linkage Disequilibrium report
NKX6-3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKX6-3 Gene

Disorders for NKX6-3 Gene

No disorders were found for NKX6-3 Gene.

No data available for UniProtKB/Swiss-Prot for NKX6-3 Gene

Publications for NKX6-3 Gene

  1. Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development. (PMID: 16326147) Alanentalo T. … Ahlgren U. (Gene Expr. Patterns 2006) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NKX6-3 Gene

Sources for NKX6-3 Gene

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