Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NKX6-2 Gene

protein-coding   GIFtS: 46
GCID: GC10M134598

NK6 Homeobox 2

(Previous names: NK6 transcription factor related, locus 2 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NK6 Homeobox 21 2     Glial And Testis-Specific Homeobox Protein2
NKX6B2 3 5     Homeobox 6B2
Homeobox Protein NK-6 Homolog B2 3     Homeobox Protein Nkx-6.22
GTX2 3     NK Homeobox Family 6, B2
NKX6.22 5     NK6 Transcription Factor Related, Locus 22
NK6 Transcription Factor Related, Locus 2 (Drosophila)1     

External Ids:    HGNC: 193211   Entrez Gene: 845042   Ensembl: ENSG000001488267   OMIM: 6059555   UniProtKB: Q9C0563   

Export aliases for NKX6-2 gene to outside databases

Previous GC identifers: GC10U990123 GC10M134475 GC10M134032 GC10M134448 GC10M128149


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NKX6-2 Gene: 
NKX6-2 (NK6 homeobox 2) is a protein-coding gene. Diseases associated with NKX6-2 include neutropenia, and ischemia. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NKX2-1.

Gene Wiki entry for NKX6-2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008818.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NKX6-2 gene promoter:
         STAT1   Pax-6   STAT1beta   STAT1alpha   MEF-2A   POU2F1   POU2F1a   Sox9   SEF-1 (1)   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNKX6-2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NKX6-2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKX6-2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

NKX6-2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKX6-2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M134598:  view genomic region     (about GC identifiers)

Start:
134,598,297 bp from pter      End:
134,599,556 bp from pter
Size:
1,260 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NKX62_HUMAN, Q9C056 (See protein sequence)
Recommended Name: Homeobox protein Nkx-6.2  
Size: 277 amino acids; 29263 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q5JSF3

Explore the universe of human proteins at neXtProt for NKX6-2: NX_Q9C056

Explore proteomics data for NKX6-2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9C056

  • NKX6-2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NKX6-2 Protein Expression
    REFSEQ proteins: NP_796374.1  
    ENSEMBL proteins: 
     ENSP00000357581  

    Human Recombinant Protein Products for NKX6-2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NKX6-2
    OriGene Protein Over-expression Lysate for NKX6-2
    OriGene MassSpec for NKX6-2 
    OriGene Custom Protein Services for NKX6-2
    GenScript Custom Purified and Recombinant Proteins Services for NKX6-2
    Novus Biologicals NKX6-2 Protein
    Novus Biologicals NKX6-2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NKX6-2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11210186

    NKX6-2 for ontologies           About GeneDecksing



    NKX6-2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NKX6-2
    GenScript Custom Superior Antibodies Services for NKX6-2
    Abcam antibodies for NKX6-2
    Cloud-Clone Corp. Antibodies for NKX6-2 
    Search ThermoFisher Antibodies for NKX6-2
    LSBio Antibodies in human, mouse, rat for NKX6-2 

    Assay Products for NKX6-2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NKX6-2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NKX6-2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NKX6-2 
    Cloud-Clone Corp. CLIAs for NKX6-2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NKL: Homeoboxes / ANTP class : NKL subclass

    5 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9C056

    ProtoNet protein and cluster: Q9C056

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: NKX62_HUMAN, Q9C056
    Similarity: Contains 1 homeobox DNA-binding domain


    NKX6-2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS11210186
    GO:0043565sequence-specific DNA binding ----
         
    NKX6-2 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Nkx6-2):
     behavior/neurological  cellular  mortality/aging  nervous system  normal 
     renal/urinary system  vision/eye 

    NKX6-2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nkx6-2Nkx6-tm1Qiu for NKX6-2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NKX6-2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NKX6-2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NKX6-2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NKX6-2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKX6-2
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NKX6-2:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidNKX6-2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NKX6-2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKX6-2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NKX6-2
    Sirion Biotech Customized adenovirus for overexpression of NKX6-2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NKX6-2 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NKX6-2 (NM_177400)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKX6-2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKX6-2
    Sirion Biotech Customized lentivirus for stable overexpression of NKX6-2 
                         Customized lentivirus expression plasmids for stable overexpression of NKX6-2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NKX6-2
    Search LifeMap BioReagents cell lines for NKX6-2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX6-2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NKX6-2

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS11210186
    GO:0010454negative regulation of cell fate commitment IEA--
    GO:0010455positive regulation of cell fate commitment IEA--
    GO:0021912regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification IEA--

    NKX6-2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NKX6-2 (NKX62)

    Search CenterWatch for drugs/clinical trials and news about NKX6-2 / NKX62

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NKX6-2 gene: 
    NM_177400.2  

    Unigene Cluster for NKX6-2:

    NK6 homeobox 2
    Hs.134013  [show with all ESTs]
    Unigene Representative Sequence: NM_177400
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368592(uc001llr.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKX6-2
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NKX6-2:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidNKX6-2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NKX6-2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKX6-2
    Clone
    Products:
         
    OriGene clones in human, mouse for NKX6-2 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NKX6-2 (NM_177400)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKX6-2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKX6-2
    Sirion Biotech Customized lentivirus for stable overexpression of NKX6-2 
                         Customized lentivirus expression plasmids for stable overexpression of NKX6-2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NKX6-2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NKX6-2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKX6-2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKX6-2

    Additional mRNA sequence: 

    BC101635.1 BC104823.1 

    1 DOTS entry:

    DT.75147528 

    2 AceView cDNA sequences:

    AI870533 NM_177400 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NKX6-2 expression in normal human tissues (normalized intensities)      NKX6-2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCGAGAGCC
    NKX6-2 Expression
    About this image


    NKX6-2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Lateral Ganglionic Eminence Progenitor Cells Lateral Ganglionic Eminence
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Lateral Ganglionic Eminence Progenitor Cells Lateral Ganglionic Eminence
             Mesencephalic Basal Plate
     
     Pancreas (Endocrine System)    fully expand to see all 5 entries
             Acinar Cells Pancreatic Acini
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Inner Cell Mass Cells Inner Cell Mass
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier

    See NKX6-2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NKX6-2

    SOURCE GeneReport for Unigene cluster: Hs.134013

    UniProtKB/Swiss-Prot: NKX62_HUMAN, Q9C056
    Tissue specificity: Highest expression in brain

        SABiosciences Custom PCR Arrays for NKX6-2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NKX6-2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NKX6-2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKX6-2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKX6-2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX6-2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NKX6-2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nkx6-21 , 5 NK6 homeobox 21, 5 88.57(n)1
    97.11(a)1
      7 (84.57 cM)5
    149121  NM_183248.31  NP_899071.21 
     1395793775 
    chicken
    (Gallus gallus)
    Aves NKX6-21 NK6 homeobox 2 82.52(n)
    88.68(a)
      395591  NM_001199548.1  NP_001186477.1 
    lizard
    (Anolis carolinensis)
    Reptilia NKX6-26
    NK6 homeobox 2
    74(a)
    1 ↔ 1
    3(59167657-59167960)
    zebrafish
    (Danio rerio)
    Actinopterygii nkx6.21 NK6 transcription factor related, locus 2 74.35(n)
    79.93(a)
      565782  NM_001135784.2  NP_001129256.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta HGTX1 CG13475-PA 59.55(n)
    58.64(a)
      53446  NM_144357.2  NP_652614.1 


    ENSEMBL Gene Tree for NKX6-2 (if available)
    TreeFam Gene Tree for NKX6-2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NKX6-2 gene
    NKX2-12  NKX6-12  HMX32  TLX22  NKX3-12  TLX12  NKX2-32  HMX22  
    NKX6-32  NKX3-22  NKX2-62  NKX2-82  NKX2-52  NKX2-22  NKX2-42  HMX12  
    TLX32  
    2 SIMAP similar genes for NKX6-2 using alignment to 1 protein entry:     NKX62_HUMAN:
    NKX6-3    NKX6-1

    NKX6-2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/73 SNPs in NKX6-2 are shown (see all 73)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0348784
    ----see VAR_0348782 V A mis40--------
    rs28040041,2
    C,F,A,H--134597898(-) CCGCTC/TGGCCG 1 -- ds500116Minor allele frequency- T:0.25NS NA WA EA 1830
    rs1437232891,2
    --134598046(+) CGAGGC/TGAGGC 1 -- ds50010--------
    rs2019234711,2
    --134598443(+) GCCGCC/GGCCGC 2 R G mis10--------
    rs2015440411,2
    --134598645(+) TTGCGA/CCACTT 2 W C mis10--------
    rs1481019981,2
    C--134598709(+) GCGGGA/GCCCGG 1 -- int10--------
    rs2008791591,2
    C--134598997(+) GGCGGA/GGTCCC 1 -- int10--------
    rs1995133961,2
    C--134599339(+) AAGCCC/GGCCGG 2 A syn10--------
    rs2014258671,2
    C,F--134599389(+) GGCCAT/GGTTGT 2 /M /L mis11Minor allele frequency- G:0.01EU 541
    rs1851953391,2
    --134599855(+) TCCCCA/GGGGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NKX6-2 (134598297 - 134599556 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/29 variations for NKX6-2 (see all 29):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509378CNV Insertion20534489
    nsv470977CNV Loss18288195
    dgv853n71CNV Loss21882294
    dgv858n71CNV Loss21882294
    dgv859n71CNV Loss21882294
    nsv896149CNV Loss21882294
    nsv832032CNV Loss17160897
    nsv832034CNV Loss17160897
    nsv896182CNV Loss21882294
    dgv857n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NKX6-2
    DNA2.0 Custom Variant and Variant Library Synthesis for NKX6-2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605955    OMIM disorders: --

    3 diseases for NKX6-2:    About MalaCards
    neutropenia    ischemia    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NKX6-2:
    Neutropenia

    NKX6-2 for disorders           About GeneDecksing


    Export disorders for NKX6-2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NKX6-2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with NKX6-2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and chromosomal location of NKX6B to 10q26, a region frequently deleted in brain tumors. (PubMed id 11210186)1, 2, 3, 9 Lee S.-H.... Belouchi A. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Gtx, an oligodendrocyte-specific homeodomain protein, has repressor activity. (PubMed id 10931524)9 Awatramani R....Kamholz J. (2000)
    6. Antisense masking reveals contributions of mRNA-rRNA base pairing to translation of Gtx and FGF2 mRNAs. (PubMed id 18832380)9 Panopoulos P. and Mauro V.P. (2008)
    7. Co-localization of Nkx6.2 and Nkx2.2 homeodomain prot eins in differentiated myelinating oligodendrocytes. (PubMed id 19780200)9 Cai J....Qiu M. (2010)
    8. Regulation of myelin development. (PubMed id 9050362)9 Kamholz J.A. (1996)
    9. The Gtx homeodomain transcription factor exerts neuroprotection using its homeodomain. (PubMed id 14754886)9 Hashimoto Y....Nishimoto I. (2004)
    10. Development of a gene-trap vector with a highly sensitive fluorescent protein reporter system for expression profiling. (PubMed id 18615730)9 Tanaka T.S....Stanford W.L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84504 HGNC: 19321 AceView: NKX6-2 Ensembl:ENSG00000148826 euGenes: HUgn84504
    ECgene: NKX6-2 H-InvDB: NKX6-2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NKX6-2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NKX6-2 gene:
    Search GeneIP for patents involving NKX6-2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NKX6-2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for NKX6-2  
     OriGene MassSpec something-or-other for NKX6-2   OriGene clones in human, mouse for NKX6-2  
     OriGene qSTAR qPCR primer pairs in human, mouse for NKX6-2   OriGene Purified Protein for NKX6-2  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NKX6-2   OriGene Custom Protein Services for NKX6-2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NKX6-2
     QIAGEN SeqTarget long-range PCR primers for resequencing NKX6-2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKX6-2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKX6-2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKX6-2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKX6-2
     GenScript Custom Purified and Recombinant Proteins Services for NKX6-2 GenScript cDNA clones with any tag delivered in your preferred vector for NKX6-2
     GenScript Custom Assay Services for NKX6-2 GenScript Custom Superior Antibodies Services for NKX6-2
     GenScript Custom overexpressing Cell Line Services for NKX6-2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NKX6-2 promoter
     Search Chromatin IP Primers for NKX6-2
     RT2 qPCR Primer Assay in human, mouse, rat NKX6-2
     Search GNC Networks for NKX6-2
     SABiosciences Custom PCR Arrays for NKX6-2
     Search Tocris compounds for NKX6-2 (NKX62)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NKX6-2 proteins
     NKX6-2 lysates
     Antibodies for NKX6-2
     See all of Abcam's Antibodies, Kits and Proteins for NKX6-2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NKX6-2
     Antibodies for NKX6-2
     ELISAs for NKX6-2
     CLIAs for NKX6-2
     Search LifeMap BioReagents cell lines for NKX6-2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX6-2
     SwitchGear 3'UTR luciferase reporter plasmids for NKX6-2
     SwitchGear Promoter luciferase reporter plasmids for NKX6-2
     Search ThermoFisher Antibodies for NKX6-2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKX6-2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NKX6-2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NKX6-2
    Customized:
     lentivirus for stable overexpression of NKX6-2
     lentivirus expression plasmids for stable overexpression of NKX6-2
     adenovirus for overexpression of NKX6-2
     LSBio Antibodies in human, mouse, rat for NKX6-2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NKX6-2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4