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Aliases for NKX6-2 Gene

Aliases for NKX6-2 Gene

  • NK6 Homeobox 2 2 3
  • NKX6B 3 4 6
  • Homeobox Protein NK-6 Homolog B 3 4
  • NKX6.2 3 6
  • GTX 3 4
  • NK6 Transcription Factor Related, Locus 2 (Drosophila) 2
  • Glial And Testis-Specific Homeobox Protein 3
  • NK6 Transcription Factor Related, Locus 2 3
  • Homeobox Protein Nkx-6.2 3
  • NK Homeobox Family 6, B 3
  • Homeobox 6B 3

External Ids for NKX6-2 Gene

Previous GeneCards Identifiers for NKX6-2 Gene

  • GC10U990123
  • GC10M134475
  • GC10M134032
  • GC10M134448
  • GC10M134598
  • GC10M128149

Summaries for NKX6-2 Gene

GeneCards Summary for NKX6-2 Gene

NKX6-2 (NK6 Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is NKX2-5.

Gene Wiki entry for NKX6-2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKX6-2 Gene

Genomics for NKX6-2 Gene

Regulatory Elements for NKX6-2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NKX6-2 Gene

132,783,179 bp from pter
132,786,052 bp from pter
2,874 bases
Minus strand

Genomic View for NKX6-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NKX6-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKX6-2 Gene

Proteins for NKX6-2 Gene

  • Protein details for NKX6-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein Nkx-6.2
    Protein Accession:
    Secondary Accessions:
    • Q5JSF3

    Protein attributes for NKX6-2 Gene

    277 amino acids
    Molecular mass:
    29263 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NKX6-2 Gene

Proteomics data for NKX6-2 Gene at MOPED

Post-translational modifications for NKX6-2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKX6-2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKX6-2 Gene

Domains for NKX6-2 Gene

Gene Families for NKX6-2 Gene

  • NKL :Homeoboxes / ANTP class : NKL subclass

Suggested Antigen Peptide Sequences for NKX6-2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9C056
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with NKX6-2: view

Function for NKX6-2 Gene

Gene Ontology (GO) - Molecular Function for NKX6-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 11210186
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NKX6-2: view
genes like me logo Genes that share phenotypes with NKX6-2: view

Animal Models for NKX6-2 Gene

MGI Knock Outs for NKX6-2:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NKX6-2 Gene

Localization for NKX6-2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKX6-2 Gene

Subcellular locations from

Jensen Localization Image for NKX6-2 Gene COMPARTMENTS Subcellular localization image for NKX6-2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NKX6-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 11210186
genes like me logo Genes that share ontologies with NKX6-2: view

Pathways for NKX6-2 Gene

SuperPathways for NKX6-2 Gene

No Data Available

Interacting Proteins for NKX6-2 Gene

Gene Ontology (GO) - Biological Process for NKX6-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 11210186
GO:0010454 negative regulation of cell fate commitment IEA --
GO:0010455 positive regulation of cell fate commitment IEA --
GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification IEA --
genes like me logo Genes that share ontologies with NKX6-2: view

No data available for Pathways by source for NKX6-2 Gene

Transcripts for NKX6-2 Gene

mRNA/cDNA for NKX6-2 Gene

(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKX6-2 Gene

NK6 homeobox 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NKX6-2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NKX6-2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKX6-2 Gene

No ASD Table

Relevant External Links for NKX6-2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NKX6-2 Gene

mRNA expression in normal human tissues for NKX6-2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKX6-2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (13.3), Brain - Substantia nigra (8.4), Brain - Hippocampus (5.3), Brain - Hypothalamus (4.6), and Brain - Putamen (basal ganglia) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NKX6-2 Gene

SOURCE GeneReport for Unigene cluster for NKX6-2 Gene Hs.134013

mRNA Expression by UniProt/SwissProt for NKX6-2 Gene

Tissue specificity: Highest expression in brain.
genes like me logo Genes that share expressions with NKX6-2: view

In Situ Assay Products

Orthologs for NKX6-2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKX6-2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NKX6-2 35
  • 98.79 (n)
  • 99.28 (a)
NKX6-2 36
  • 99 (a)
(Bos Taurus)
Mammalia NKX6-2 36
  • 93 (a)
(Canis familiaris)
Mammalia NKX6-2 35
  • 95.03 (n)
  • 97.09 (a)
NKX6-2 36
  • 95 (a)
(Mus musculus)
Mammalia Nkx6-2 35
  • 88.57 (n)
  • 97.11 (a)
Nkx6-2 16
Nkx6-2 36
  • 97 (a)
(Monodelphis domestica)
Mammalia NKX6-2 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
-- 36
  • 82 (a)
(Rattus norvegicus)
Mammalia Nkx6-2 35
  • 89.05 (n)
  • 97.11 (a)
(Gallus gallus)
Aves NKX-6.2 36
  • 85 (a)
NKX6-2 35
  • 80.63 (n)
  • 85.66 (a)
(Anolis carolinensis)
Reptilia NKX6-2 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nkx6-2 35
  • 72.99 (n)
  • 79.18 (a)
(Danio rerio)
Actinopterygii nkx6.2 35
  • 72.99 (n)
  • 77.7 (a)
nkx6.2 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta HGTX 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for NKX6-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKX6-2 Gene

Gene Tree for NKX6-2 (if available)
Gene Tree for NKX6-2 (if available)

Paralogs for NKX6-2 Gene

Selected SIMAP similar genes for NKX6-2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKX6-2: view

Variants for NKX6-2 Gene

Sequence variations from dbSNP and Humsavar for NKX6-2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2472046 -- 132,787,880(-) TCGGG(A/C)GACCC upstream-variant-2KB
rs2737398 -- 132,786,368(-) CAAGC(G/T)GGATT upstream-variant-2KB
rs2804004 -- 132,784,394(-) CCGCT(C/T)GGCCG downstream-variant-500B
rs12243230 -- 132,787,402(+) CCGGG(A/G)CAGTG upstream-variant-2KB
rs12249116 -- 132,787,509(+) GTCGA(C/G)TCCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NKX6-2 Gene

Variant ID Type Subtype PubMed ID
nsv896149 CNV Loss 21882294
dgv850n71 CNV Loss 21882294
dgv851n71 CNV Loss 21882294
dgv852n71 CNV Loss 21882294
nsv896182 CNV Loss 21882294
nsv832032 CNV Loss 17160897
nsv896183 CNV Loss 21882294
nsv470977 CNV Loss 18288195
dgv853n71 CNV Loss 21882294
nsv896187 CNV Loss 21882294
nsv509378 CNV Insertion 20534489
nsv467496 CNV Gain 19166990
dgv854n71 CNV Loss 21882294
nsv896194 CNV Loss 21882294
nsv832033 CNV Loss 17160897
dgv855n71 CNV Loss 21882294
dgv856n71 CNV Loss 21882294
nsv832034 CNV Loss 17160897
dgv183n67 CNV Gain 20364138
dgv857n71 CNV Loss 21882294
dgv858n71 CNV Loss 21882294
dgv859n71 CNV Loss 21882294
nsv825660 CNV Gain 20364138
nsv896205 CNV Loss 21882294
dgv184n67 CNV Gain 20364138
nsv825663 CNV Gain 20364138
nsv896206 CNV Loss 21882294
dgv860n71 CNV Loss 21882294
esv32864 CNV Gain 17666407

Relevant External Links for NKX6-2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKX6-2 Gene

Disorders for NKX6-2 Gene

(1) University of Copenhagen DISEASES for NKX6-2 Gene

genes like me logo Genes that share disorders with NKX6-2: view

No data available for UniProtKB/Swiss-Prot for NKX6-2 Gene

Publications for NKX6-2 Gene

  1. Cloning, expression and chromosomal location of NKX6B to 10q26, a region frequently deleted in brain tumors. (PMID: 11210186) Lee S.-H. … Belouchi A. (Mamm. Genome 2001) 2 3 4 23
  2. The Gtx homeodomain transcription factor exerts neuroprotection using its homeodomain. (PMID: 14754886) Hashimoto Y. … Nishimoto I. (J. Biol. Chem. 2004) 23
  3. N-acetylcysteine prevents endotoxin-induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain. (PMID: 15389835) Paintlia M.K. … Singh A.K. (J. Neurosci. Res. 2004) 23
  4. Development of a gene-trap vector with a highly sensitive fluorescent protein reporter system for expression profiling. (PMID: 18615730) Tanaka T.S. … Stanford W.L. (Genesis 2008) 23
  5. Antisense masking reveals contributions of mRNA-rRNA base pairing to translation of Gtx and FGF2 mRNAs. (PMID: 18832380) Panopoulos P. … Mauro V.P. (J. Biol. Chem. 2008) 23

Products for NKX6-2 Gene

Sources for NKX6-2 Gene

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