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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NKX6-1 Gene

protein-coding   GIFtS: 51
GCID: GC04M085339

NK6 homeobox 1

(Previous names: NK homeobox (Drosophila), family 6, A, NK6 transcription...)
(Previous symbol: NKX6A)
 Explore 5 diseases affiliated with
NKX6-1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NKX6-1    

Aliases
for NKX6-1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NK6 Homeobox 11 2     NKX6.12
NKX6A1 2 3 5     Homeobox Protein Nkx-6.12
Homeobox Protein NK-6 Homolog A2 3     NK Homeo Box, Family 6, Member A2
Nkx6.11     NK Homeobox, Family 6, A2
NK Homeobox (Drosophila), Family 6, A1     NK6 Transcription Factor Homolog A2
NK6 Transcription Factor Related, Locus 1 (Drosophila)1     NK6 Transcription Factor Related, Locus 12

External Ids:    HGNC: 78391   Entrez Gene: 48252   Ensembl: ENSG000001636237   OMIM: 6025635   UniProtKB: P784263   

Export aliases for NKX6-1 gene to outside databases

Previous GC identifers: GC04M085708 GC04M085807 GC04M085872 GC04M085771 GC04M081156


Summaries
for NKX6-1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NKX6-1:
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription
regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed
15056733).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: NKX61_HUMAN, P78426
Function: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of
genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in
regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the
appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are
induced by SHH signals (By similarity)

Gene Wiki entry for NKX6-1


Genomic Views
for NKX6-1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NKX6-1 gene promoter:
         TBP   GR   Sp1   GR-beta   POU6F1 (c2)   YY1   AREB6   POU2F1   POU2F1a   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NKX6-1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKX6-1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.33   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q21.33

NKX6-1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKX6-1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M085339:  view genomic region     (about GC identifiers)

Start:
 85,413,061 bp from pter      End:
 85,419,603 bp from pter
Size:
 6,543 bases      Orientation:
 minus strand

Proteins
for NKX6-1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NKX61_HUMAN, P78426 (See protein sequence)
Recommended Name: Homeobox protein Nkx-6.1  
Size: 367 amino acids; 37849 Da
Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for NKX6-1: NX_P78426

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P78426

    • NKX6-1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006159.2  
    ENSEMBL proteins: 
     ENSP00000295886   ENSP00000449761  
    Reactome Protein details: P78426
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: NKX6-1
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    Novus Biologicals NKX6-1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NKX6-1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0044424intracellular part ----


    NKX6-1 for ontologies           About GeneDecksing



    NKX6-1 Antibody Products: 
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    Uscn ELISAs and CLIAs for NKX6-1

    Protein Domains /
    Families
    for NKX6-1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NKX6-1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR020479 Homeobox_metazoa
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P78426

    ProtoNet protein and cluster: P78426

    1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: NKX61_HUMAN, P78426
    Domain: The C-terminal domain contributes to sequence-specific DNA-binding (By similarity)
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for NKX6-1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NKX61_HUMAN, P78426
    Function: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of
    genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in
    regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the
    appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are
    induced by SHH signals (By similarity)

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKX6-1
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    OriGene shRNA RFP: NKX6-1
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NKX6-1

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for NKX6-1

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NKX6-1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ----


    NKX6-1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Nkx6-1Nkx6-tm1Jlr for NKX6-1
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nkx6-1):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  nervous system 
     no phenotypic analysis 

    NKX6-1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NKX6-1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of beta-cell development
    		Regulation of beta-cell development1.00
    		Regulation of gene expression in beta cells0.56
    		Maturity onset diabetes of the young0.56
    2Regulation of gene expression in early pancreatic precursor cells
    		Regulation of gene expression in early pancreatic precursor cells1.00
    		PDX1-dependent synthesis of NKX6-1 protein0.17
    		PDX1-dependent synthesis of NKX6-1 protein0.17
    3Axon guidance
    		Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for NKX6-1 (see all 6)
        Regulation of gene expression in beta cells
    Developmental Biology
    PDX1-dependent synthesis of NKX6-1 protein
    Regulation of beta-cell development
    PDX1-dependent synthesis of NKX6-1 protein


    1         Kegg Pathway  (Kegg details for NKX6-1):
        Maturity onset diabetes of the young


    NKX6-1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NKX6-1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for NKX6-1 (ENSP000002958864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGF10ENSP000002646644STRING: ENSP00000264664
    FOXA2ENSP000003159554STRING: ENSP00000315955
    FOXO1ENSP000003688804STRING: ENSP00000368880
    ONECUT1ENSP000003026304STRING: ENSP00000302630
    NKX2-2ENSP000003663474STRING: ENSP00000366347
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0003323type B pancreatic cell development ----
    GO:0006351transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter IEA--


    NKX6-1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NKX6-1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NKX6-1
    Search CenterWatch for drugs/clinical trials and news about NKX6-1 / NKX61 

    Transcripts
    for NKX6-1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NKX6-1 gene: 
    NM_006168.2  

    Unigene Cluster for NKX6-1:

    NK6 homeobox 1
    Hs.546270  [show with all ESTs]
    Unigene Representative Sequence: BU557077
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295886(uc003hpa.1) ENST00000515820

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKX6-1
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKX6-1
    OriGene shRNA RFP: NKX6-1
    OriGene siRNA: NKX6-1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKX6-1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NKX6-1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NKX6-1 (NM_006168)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NKX6-1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKX6-1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKX6-1

    1 DOTS entry:

    DT.91946079 

    19 AceView cDNA sequences:

    NM_006168 BM142294 CK820199 BM142348 CK820089 CA776168 BM142445 CK820090 
    CA866205 BU553046 BM354144 CK820198 CA775949 BU844509 CA775565 CA941174 
    BM273181 AW302947 BU557077 

    GeneLoc Exon Structure


    Expression
    for NKX6-1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NKX6-1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCGTGGCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NKX6-1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/33 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 33) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeVentral Foregut EndodermVentral Foregut Endoderm CellsEndoderm
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Spinal CordMotor Neural Progenitor DomainMotor Neural Progenitor CellsMotor Neurons
    Spinal CordMotor Neural Progenitor DomainMotor NeuronsMotor Neurons
    Spinal CordV2 Neural Progenitor DomainV2 InterneuronsMotor Neurons
    Spinal CordV2 Neural Progenitor DomainV2 Neural Progenitor CellsMotor Neurons
    Spinal CordV3 Neural Progenitor DomainV3 Neural Progenitor CellsMotor Neurons
    Neural TubeDiencephalic Ventricular ZoneMeso-diencephalic Dopaminergic Precursor CellsDopaminergic neurons
    Neural TubeMesencephalic Ventricular ZoneMeso-diencephalic Dopaminergic Precursor CellsDopaminergic neurons
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/12 LifeMap Cells (see all 12) 
    NameCategory
    GABA neuron-like cells (Generation of motor ...)Brain
    Anterior foregut progenitor cells (Directed differentia...)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Indolactam V-induced cells (Derivation of pancre...)
    Pancreatic endoderm-like cells (Generation of beta c...)
    Endocrine progenitors (Generation of pancre...)
    Posterior foregut (Generation of pancre...)
    Motor neuron-like cells (Generation of motor ...)
    N2-induced embryoid bodies (Generation of motor ...)
    Motor neuron progenitors (Generation of motor ...)

    See NKX6-1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NKX6-1

    SOURCE GeneReport for Unigene cluster: Hs.546270

    UniProtKB/Swiss-Prot: NKX61_HUMAN, P78426
    Tissue specificity: Pancreatic beta cells

        SABiosciences Custom PCR Arrays for NKX6-1
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NKX6-1

    Orthologs
    for NKX6-1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NKX6-1 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NKX6-11 NK6 homeobox 1 67.8(n)
    67.92(a)    		   395752  XM_003641196.1  XP_003641244.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NOTO6
    		 --
    		 71(a)
    		 1 ↔ 1
    		 3(59167657-59167960)
    zebrafish
    (Danio rerio)    		 Actinopterygii nkx6.11 NK6 transcription factor related, locus 1 (Drosophila) 71.99(n)
    83.39(a)    		   436748  NM_001002475.1  NP_001002475.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta HGTX6
    		 HGTX
    		 24(a)
    		 possible ortholog
    		 3L(14576322-14592640)
    barley
    (Hordeum vulgare)    		 Liliopsida Hv.18362 Transcribed sequence with weak similarity to protein more 71.98(n)    BM816734.1 


    ENSEMBL Gene Tree for NKX6-1 (if available)
    TreeFam Gene Tree for NKX6-1 (if available) 

    Paralogs
    for NKX6-1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NKX6-1 gene
    NOTO2  NKX6-32  EMX22  NKX6-22  EMX12  
    18 SIMAP similar genes for NKX6-1 using alignment to 2 protein entries:     NKX61_HUMAN (see all proteins):
    HMX1    NKX1-2    NKX1-1    HMX2    HOXB1    HOXC13
    HOXB7    HOXD8    UNCX    HLX    MNX1    homeobox gene
    HOXB8    NKX6-2    NKX6-3    DUX2    HOXA4    HOXC6

    NKX6-1 for paralogs           About GeneDecksing



    Genomic Variants
    for NKX6-1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKX6-1
    DNA2.0 Custom Variant and Variant Library Synthesis for NKX6-1

    Disorders / Diseases
    for NKX6-1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NKX6-1 for disorders           About GeneDecksing

    OMIM gene information: 602563    OMIM disorders: --

    5 diseases for NKX6-1:    About MalaCards
    maturity-onset diabetes of the young    hermaphroditism    pancreatitis    hepatitis
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: NKX6-1 (1 document)

    Export disorders for NKX6-1 gene to outside databases

    Publications
    for NKX6-1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NKX6-1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with NKX6-1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene. (PubMed id 9119408)1, 2, 3, 9 Inoue H....Permutt M.A. (1997)
    2. Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells. (PubMed id 20106981)1, 9 Donelan W....Yang L.J. (2010)
    3. Isolation of mineralizing Nestin+ Nkx6.1+ vascular mus cular cells from the adult human spinal cord. (PubMed id 21985235)1 Mamaeva D....Hugnot J.P. (2011)
    4. NKX6.1 promotes PDX-1-induced liver to pancreatic I^-c ells reprogramming. (PubMed id 21108535)1 Gefen-Halevi S....Ferber S. (2010)
    5. Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia. (PubMed id 18754095)1 Zhu S....Wong B.C. (2009)
    6. Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. (PubMed id 18347054)1 Schisler J.C....Newgard C.B. (2008)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects. (PubMed id 16873704)1 Yokoi N....Seino S. (2006)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    10. Differentiation of insulin-producing cells from human neural progenitor cells. (PubMed id 15839736)1 Hori Y....Kim S.K. (2005)

    External Searches for NKX6-1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing NKX6-1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4825 HGNC: 7839 AceView: NKX6-1 Ensembl:ENSG00000163623 euGenes: HUgn4825
    ECgene: NKX6-1 Kegg: 4825 H-InvDB: NKX6-1

    Other Databases showing NKX6-1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NKX6-1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NKX6-1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NKX6-1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NKX6-1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NKX6-1 gene:
    Search GeneIP for patents involving NKX6-1

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