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NKX6-1 Gene

protein-coding   GIFtS: 55
GCID: GC04M085413

NK6 Homeobox 1

(Previous names: NK homeobox (Drosophila), family 6, A, NK6 transcription...)
(Previous symbol: NKX6A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NK6 Homeobox 11 2     Homeobox Protein Nkx-6.12
NKX6A1 2 3 5     NK Homeo Box, Family 6, Member A2
Homeobox Protein NK-6 Homolog A2 3     NK Homeobox, Family 6, A2
NK Homeobox (Drosophila), Family 6, A1     NK6 Transcription Factor Homolog A2
NK6 Transcription Factor Related, Locus 1 (Drosophila)1     NK6 Transcription Factor Related, Locus 12
NKX6.12     

External Ids:    HGNC: 78391   Entrez Gene: 48252   Ensembl: ENSG000001636237   OMIM: 6025635   UniProtKB: P784263   

Export aliases for NKX6-1 gene to outside databases

Previous GC identifers: GC04M085339 GC04M085708 GC04M085807 GC04M085872 GC04M085771 GC04M081156


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NKX6-1 Gene:
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription
regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed
15056733).(supplied by OMIM, Mar 2008)

GeneCards Summary for NKX6-1 Gene:
NKX6-1 (NK6 homeobox 1) is a protein-coding gene. Diseases associated with NKX6-1 include maturity-onset diabetes of the young, and neuronitis. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NKX2-3.

UniProtKB/Swiss-Prot: NKX61_HUMAN, P78426
Function: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number
of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is
involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of
motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal
progenitor factors, which are induced by SHH signals (By similarity)

Gene Wiki entry for NKX6-1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NKX6-1 gene promoter:
         TBP   GR   Sp1   GR-beta   POU6F1 (c2)   YY1   AREB6   POU2F1   POU2F1a   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NKX6-1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKX6-1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.33   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q21.33

NKX6-1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKX6-1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M085413:  view genomic region     (about GC identifiers)

Start:
85,413,140 bp from pter      End:
85,419,603 bp from pter
Size:
6,464 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NKX61_HUMAN, P78426 (See protein sequence)
Recommended Name: Homeobox protein Nkx-6.1  
Size: 367 amino acids; 37849 Da

Explore the universe of human proteins at neXtProt for NKX6-1: NX_P78426

Explore proteomics data for NKX6-1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NKX6-1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006159.2  
    ENSEMBL proteins: 
     ENSP00000449761   ENSP00000295886  
    Reactome Protein details: P78426

    NKX6-1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NKL: Homeoboxes / ANTP class : NKL subclass

    5 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P78426

    ProtoNet protein and cluster: P78426

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: NKX61_HUMAN, P78426
    Domain: The C-terminal domain contributes to sequence-specific DNA-binding (By similarity)
    Similarity: Contains 1 homeobox DNA-binding domain


    NKX6-1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKX61_HUMAN, P78426
    Function: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number
    of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is
    involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of
    motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal
    progenitor factors, which are induced by SHH signals (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ----
         
    NKX6-1 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Nkx6-1):
     behavior/neurological  cellular  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging 
     nervous system  no phenotypic analysis 

    NKX6-1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nkx6-1Nkx6-tm1Jlr for NKX6-1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NKX6-1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NKX6-1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NKX6-1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NKX6-1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GKTAATGR 

    miRNA
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    miRTarBase miRNAs that target NKX6-1:
    hsa-mir-196a-5p (MIRT048171)

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKX6-1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX6-1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NKX61_HUMAN, P78426: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    NKX6-1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NKX6-1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of beta-cell development
    Regulation of beta-cell development0.64
    Maturity onset diabetes of the young0.61
    Regulation of gene expression in beta cells0.64
    Regulation of gene expression in early pancreatic precursor cells0.00
    2L1CAM interactions
    Developmental Biology0.63

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for NKX6-1
        Regulation of gene expression in beta cells
    Regulation of gene expression in early pancreatic precursor cells


    1 Kegg Pathway  (Kegg details for NKX6-1):
        Maturity onset diabetes of the young


    NKX6-1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NKX6-1
    Interactions:

        GeneGlobe Interaction Network for NKX6-1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for NKX6-1 (ENSP000002958864) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGF10ENSP000002646644STRING: ENSP00000264664
    FOXO1ENSP000003688804STRING: ENSP00000368880
    ONECUT1ENSP000003026304STRING: ENSP00000302630
    NKX2-2ENSP000003663474STRING: ENSP00000366347
    NACAENSP000004038174STRING: ENSP00000403817
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0003323type B pancreatic cell development ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter IEA--

    NKX6-1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NKX6-1 (NKX61)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NKX6-1 gene: 
    NM_006168.2  

    Unigene Cluster for NKX6-1:

    NK6 homeobox 1
    Hs.546270  [show with all ESTs]
    Unigene Representative Sequence: BU557077
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515820 ENST00000295886(uc003hpa.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NKX6-1
      QuantiFast Probe-based Assays in human, mouse, rat NKX6-1

    1 DOTS entry:

    DT.91946079 

    19 AceView cDNA sequences:

    CK820199 BM142294 NM_006168 CK820090 BM142348 CK820089 BU553046 CA866205 
    CK820198 CA776168 BM142445 CA775949 BM354144 CA775565 BU844509 CA941174 
    AW302947 BM273181 BU557077 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NKX6-1 expression in normal human tissues (normalized intensities)      NKX6-1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGTGGCCT
    NKX6-1 Expression
    About this image


    NKX6-1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 27 entries
             Mature Beta Cells Islets of Langerhans
             Indolactam V-induced cells
     
     Neural Tube (Nervous System)    fully expand to see all 9 entries
             Late MN Progenitor Cells Motor Neural Progenitor Domain
             N2-induced embryoid bodies
     
     Spinal Cord (Nervous System)    fully expand to see all 6 entries
             Motor Neurons Motor Neural Progenitor Domain
             Motor neuron-like cells
     
     Neurons
             Motor Neurons Motor Neural Progenitor Domain
             Motor neuron-like cells
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 4 entries
             Ventral Foregut Endoderm Cells Ventral Foregut Endoderm
             Anterior foregut progenitor cells
    NKX6-1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NKX6-1 Protein Expression

    Genevestigator expression for NKX6-1

    SOURCE GeneReport for Unigene cluster: Hs.546270

    UniProtKB/Swiss-Prot: NKX61_HUMAN, P78426
    Tissue specificity: Pancreatic beta cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NKX6-1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nkx6-11 , 5 NK6 homeobox 11, 5 89.01(n)1
    96.15(a)1
      5 (48.84 cM)5
    180961  NM_144955.21  NP_659204.11 
     1016581395 
    lizard
    (Anolis carolinensis)
    Reptilia NKX6-16
    NK6 homeobox 1
    94(a)
    1 ↔ 1
    5(43836459-43836674)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nkx6-11 NK6 homeobox 1 72.78(n)
    83.54(a)
      549337  NM_001016583.3  NP_001016583.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nkx6.11 NK6 homeobox 1 70.68(n)
    80.78(a)
      436748  NM_001002475.1  NP_001002475.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta HGTX6
    HGTX
    30(a)
    1 → many
    3L(14576322-14592640)
    barley
    (Hordeum vulgare)
    Liliopsida Hv.18362 Transcribed sequence with weak similarity to protein more 71.98(n)    BM816734.1 


    ENSEMBL Gene Tree for NKX6-1 (if available)
    TreeFam Gene Tree for NKX6-1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NKX6-1 gene
    NKX2-32  TLX12  HMX22  NKX6-32  NKX3-22  NKX6-22  NKX2-82  NKX2-62  
    NKX2-12  NKX2-52  NKX2-22  NKX2-42  HMX32  TLX32  HMX12  TLX22  
    NKX3-12  
    9 SIMAP similar genes for NKX6-1 using alignment to 2 protein entries:     NKX61_HUMAN (see all proteins):
    NKX1-2    HMX2    NKX6-2    HOXB1    HOXC13    HLX
    HOXB8    DUX2    HOXA4

    NKX6-1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NKX6-1 (see all 147)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1485575281,2
    --85414011(+) CGCTTC/TGCTCC 1 -- ds50010--------
    rs729593331,2
    C,F--85414028(+) CCCCAT/AGCGGT 1 -- ds50012Minor allele frequency- A:0.20WA 120
    rs76709361,2
    C,F,H--85414320(+) CCCGCA/GGGCAG 1 -- ds500112Minor allele frequency- G:0.07NS EA NA CSA WA 1374
    rs1119075961,2
    C--85414433(+) GCGGGC/G/TGGCGG 1 -- ds50011WA 2
    rs1434580041,2
    C,F--85414483(+) GAGGCC/AGCCGC 2 /G /C mis11Minor allele frequency- A:0.00NA 4440
    rs1829117731,2
    C--85414509(+) ACTTGC/TGCTTC 2 H R mis10--------
    rs2012256461,2
    C--85414538(+) TTCTCG/ATCGTC 2 /D syn11Minor allele frequency- A:0.00EU 1323
    rs2006959371,2
    --85414570(+) ATTGTA/TGTCGT 2 N Y mis10--------
    rs2001487421,2
    --85414571(+) TTGTAA/GTCGTC 2 D syn10--------
    rs2000377721,2
    C--85414579(+) GTCGTC/TCTCTT 2 N D mis10--------

    HapMap Linkage Disequilibrium report for NKX6-1 (85413140 - 85419603 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NKX6-1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829998CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NKX6-1
    DNA2.0 Custom Variant and Variant Library Synthesis for NKX6-1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602563    OMIM disorders: --

    4 diseases for NKX6-1:    About MalaCards
    maturity-onset diabetes of the young    neuronitis    pancreatitis    hepatitis


    NKX6-1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NKX6-1
    Human Genome Epidemiology (HuGE) Navigator: NKX6-1 (1 document)

    Export disorders for NKX6-1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NKX6-1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with NKX6-1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene. (PubMed id 9119408)1, 2, 3, 9 Inoue H....Permutt M.A. (Genomics 1997)
    2. Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects. (PubMed id 16873704)1, 4 Yokoi N....Seino S. (Diabetes 2006)
    3. Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells. (PubMed id 20106981)1, 9 Donelan W....Yang L.J. (J. Biol. Chem. 2010)
    4. Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cord. (PubMed id 21985235)1 Mamaeva D....Hugnot J.P. (BMC Neurosci 2011)
    5. NKX6.1 promotes PDX-1-induced liver to pancreatic I^-cells reprogramming. (PubMed id 21108535)1 Gefen-Halevi S....Ferber S. (Cell Reprogram 2010)
    6. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    7. Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia. (PubMed id 18754095)1 Zhu S....Wong B.C. (Dig. Dis. Sci. 2009)
    8. Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. (PubMed id 18347054)1 Schisler J.C....Newgard C.B. (Mol. Cell. Biol. 2008)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4825 HGNC: 7839 AceView: NKX6-1 Ensembl:ENSG00000163623 euGenes: HUgn4825
    ECgene: NKX6-1 Kegg: 4825 H-InvDB: NKX6-1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NKX6-1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NKX6-1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NKX6-1 gene:
    Search GeneIP for patents involving NKX6-1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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