Aliases for NKX6-1 Gene
External Ids for NKX6-1 Gene
Previous HGNC Symbols for NKX6-1 Gene
Previous GeneCards Identifiers for NKX6-1 Gene
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]
GeneCards Summary for NKX6-1 Gene
NKX6-1 (NK6 Homeobox 1) is a Protein Coding gene. Diseases associated with NKX6-1 include Maturity-Onset Diabetes Of The Young and Non-Functioning Pancreatic Endocrine Tumor. Among its related pathways are Regulation of beta-cell development and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is NKX6-2.
UniProtKB/Swiss-Prot for NKX6-1 Gene
Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).