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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NKX3-2 Gene

protein-coding   GIFtS: 50
GCID: GC04M013542

NK3 Homeobox 2

(Previous name: bagpipe homeobox homolog 1 (Drosophila))
(Previous symbol: BAPX1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NK3 Homeobox 21 2     SMMD2 5
BAPX11 2 3 5     Bagpipe Homeobox Homolog 1 (Drosophila)1
Bagpipe Homeobox Protein Homolog 12 3     NKX3.22
Homeobox Protein NK-3 Homolog B2 3     Homeobox Protein Nkx-3.22
NKX3B2 3     

External Ids:    HGNC: 9511   Entrez Gene: 5792   Ensembl: ENSG000001097057   OMIM: 6021835   UniProtKB: P783673   

Export aliases for NKX3-2 gene to outside databases

Previous GC identifers: GC04M013152 GC04M012880


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NKX3-2 Gene:
This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role
in skeletal development. (provided by RefSeq, Jul 2008)

GeneCards Summary for NKX3-2 Gene: 
NKX3-2 (NK3 homeobox 2) is a protein-coding gene. Diseases associated with NKX3-2 include spondylo-megaepiphyseal-metaphyseal dysplasia, and bone osteosarcoma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NKX2-1.

UniProtKB/Swiss-Prot: NKX32_HUMAN, P78367
Function: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in
distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type
epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring
and gonium development and in the regulation of the width of the malleus (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_006316.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NKX3-2 gene promoter:
         Sox9   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNKX3-2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NKX3-2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKX3-2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p15.33   HGNC cytogenetic band: 4p16.3

NKX3-2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKX3-2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M013542:  view genomic region     (about GC identifiers)

Start:
13,542,454 bp from pter      End:
13,546,674 bp from pter
Size:
4,221 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NKX32_HUMAN, P78367 (See protein sequence)
Recommended Name: Homeobox protein Nkx-3.2  
Size: 333 amino acids; 34814 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q2M2I7

Explore the universe of human proteins at neXtProt for NKX3-2: NX_P78367

Explore proteomics data for NKX3-2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78367

  • NKX3-2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NKX3-2 Protein Expression
    REFSEQ proteins: NP_001180.1  
    ENSEMBL proteins: 
     ENSP00000371875  

    Human Recombinant Protein Products for NKX3-2: 
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    Cloud-Clone Corp. Proteins for NKX3-2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    NKX3-2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NKL: Homeoboxes / ANTP class : NKL subclass

    4 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P78367

    ProtoNet protein and cluster: P78367

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: NKX32_HUMAN, P78367
    Similarity: Belongs to the NK-3 homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    NKX3-2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKX32_HUMAN, P78367
    Function: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in
    distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type
    epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring
    and gonium development and in the regulation of the width of the malleus (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    NKX3-2 for ontologies           About GeneDecksing


    Phenotypes:
         15/17 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Nkx3-2) (see all 17):
     cellular  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  hematopoietic system  immune system  limbs/digits/tail 
     mortality/aging  muscle  nervous system  no phenotypic analysis  normal 

    NKX3-2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NKX3-2: Nkx3-2Nkx3-tm1Tlu Nkx3-2Nkx3-tm1Bobh Nkx3-2Nkx3-tm1.1Tlu

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NKX3-2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NKX3-2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NKX3-2 
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    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate NKX3-2 (see all 39):
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NKX3-2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Endochondral Ossification
    Endochondral Ossification


    1 BioSystems Pathway for NKX3-2
        Endochondral Ossification


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NKX3-2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for NKX3-2 (P783673 ENSP000003718754) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBBP4Q090283, ENSP000003625924I2D: score=1 STRING: ENSP00000362592
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    RBBP7Q165763, ENSP000003694274I2D: score=1 STRING: ENSP00000369427
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    SMAD1Q157973, ENSP000003057694I2D: score=1 STRING: ENSP00000305769
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS9344671
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS9344671
    GO:0007368determination of left/right symmetry IEA--
    GO:0031016pancreas development IEA--

    NKX3-2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NKX3-2 (NKX32)

    Search CenterWatch for drugs/clinical trials and news about NKX3-2 / NKX32

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NKX3-2 gene: 
    NM_001189.3  

    Unigene Cluster for NKX3-2:

    NK3 homeobox 2
    Hs.590927  [show with all ESTs]
    Unigene Representative Sequence: NM_001189
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000382438(uc003gmx.2)
    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate NKX3-2 (see all 39):
    hsa-miR-4291 hsa-miR-429 hsa-miR-106a hsa-miR-128 hsa-miR-93 hsa-miR-23a hsa-miR-200b hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmidNKX3-2 3' UTR sequence
    Inhib. RNA
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      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKX3-2

    Additional mRNA sequence: 

    AF009801.1 BC111966.1 

    1 DOTS entry:

    DT.305353 

    5 AceView cDNA sequences:

    NM_001189 AF009801 AW072750 AW073413 BE833010 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NKX3-2 expression in normal human tissues (normalized intensities)      NKX3-2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NKX3-2 Expression
    About this image


    NKX3-2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/49 selected tissues (see all 49) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 37 entries
             Immature Endochondral Osteoblasts Thoracic Vertebrae
             Zeugopod Growth Plate
             HyStem+BMP4-induced 4D20.8 cells
             Human Vertebral Mesenchymal Stem Cells (HVMSC)   
             skeleton/cranium   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 34 entries
             Chondrocytes Synchondroses
             HyStem+BMP4-induced 4D20.8 cells
             Human Annulus Fibrosus Cells (HAFC)   
             fetal cartilage   
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Midbrain tegmentum
             brain/hindbrain   
     
     Somite (Muscoskeletal System)    fully expand to see all 10 entries
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
             skeleton/axial skeleton   
     
     Epithelium
             oral mucosa ; squamous epithelial cells   

    See NKX3-2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NKX3-2

    SOURCE GeneReport for Unigene cluster: Hs.590927

    UniProtKB/Swiss-Prot: NKX32_HUMAN, P78367
    Tissue specificity: Expressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and
    colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic
    skeleton

        SABiosciences Expression via Pathway-Focused PCR Array including NKX3-2: 
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX3-2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NKX3-2 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nkx3-21 , 5 NK3 homeobox 21, 5 83.98(n)1
    85.29(a)1
      5 (22.58 cM)5
    120201  NM_007524.31  NP_031550.21 
     417614835 
    African clawed frog
    (Xenopus laevis)
    Amphibia bapx1-A2 bagpipe homeobox homolog 1 (Drosophila) 76.98(n)    U75487.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bapx12 bagpipe homeobox homolog 1 75.83(n)   337865  AY225416.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bap6
    bagpipe
    24(a)
    1 ↔ 1
    3R(17214605-17216171)


    ENSEMBL Gene Tree for NKX3-2 (if available)
    TreeFam Gene Tree for NKX3-2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NKX3-2 gene
    NKX2-12  NKX6-12  HMX32  TLX22  NKX3-12  TLX12  NKX2-32  HMX22  
    NKX6-32  NKX6-22  NKX2-62  NKX2-82  NKX2-52  NKX2-22  NKX2-42  HMX12  
    TLX32  

    NKX3-2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/110 SNPs in NKX3-2 are shown (see all 110)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs14762111,2
    C,F,O,A,H--13482128(-) AGGAGT/CGTTTC 1 -- ds500125Minor allele frequency- C:0.25MN EA NA NS WA 4047
    rs1426946751,2
    --13482266(+) TCACAC/GGGAGG 1 -- ds50010--------
    rs1818146231,2
    --13482365(+) GCTGCC/TCAGGT 1 -- ds50010--------
    rs1841828751,2
    --13482482(+) CAGCTA/CGCCTT 1 -- ds50010--------
    rs1476336951,2
    C--13482493(+) ACTGGG/TTCCCC 1 -- ds50010--------
    rs1114457701,2
    C--13482763(+) CAGAGG/AGCAGA 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs38222261,2
    C,F,A,H--13482766(+) AGGGCA/GGAAGG 1 -- ut31 ese322Minor allele frequency- G:0.20NS EA NA WA CSA 2349
    rs792705901,2
    C,F--13482962(+) TGTGCG/TCTCTC 1 -- ut311Minor allele frequency- T:0.11WA 118
    rs46987121,2
    C,F,A,H--13482979(+) CCGGGG/ACTCCC 1 -- ut31 ese319Minor allele frequency- A:0.19NS NA WA CSA EA 1492
    rs1893661441,2
    --13483102(+) CACCCC/GCACCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NKX3-2 (13542454 - 13546674 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NKX3-2: --

    Human Gene Mutation Database (HGMD): NKX3-2
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NKX3-2
    DNA2.0 Custom Variant and Variant Library Synthesis for NKX3-2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602183   
    OMIM disorders: 613330  
    UniProtKB/Swiss-Prot: NKX32_HUMAN, P78367
  • Spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD) [MIM:613330]: A skeletal dysplasia characterized by
    disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion
    contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of
    large epiphyseal ossification centers and wide growth plates in the long tubular bones, and numerous
    pseudoepiphyses of the short tubular bones in hands and feet. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 7 diseases for NKX3-2:    About MalaCards
    spondylo-megaepiphyseal-metaphyseal dysplasia    bone osteosarcoma    metaphyseal dysplasia    goldenhar syndrome
    skeletal dysplasias    osteosarcoma    short stature

    1 disease from the University of Copenhagen DISEASES database for NKX3-2:
    Metaphyseal dysplasia

    NKX3-2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: NKX3-2 (1 document)

    Export disorders for NKX3-2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NKX3-2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with NKX3-2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia. (PubMed id 9344671)1, 2, 3 Yoshiura K. and Murray J.C. (1997)
    2. Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton. (PubMed id 9256352)1, 2, 9 Tribioli C.... Lufkin T. (1997)
    3. Homozygous inactivating mutations in the NKX3-2 gene result in spondylo-megaepiphyseal-metaphyseal dysplasia. (PubMed id 20004766)1, 2 Hellemans J....Mortier G. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Molecular cloning, chromosomal mapping and developmental expression of BAPX1, a novel human homeobox-containing gene homologous to Drosophila bagpipe. (PubMed id 9426254)1, 2 Tribioli C. and Lufkin T. (1997)
    6. Indian Hedgehog signalling triggers Nkx3.2 protein deg radation during chondrocyte maturation. (PubMed id 22507129)1 Choi S.W....Kim D.W. (2012)
    7. Exogenous signal-independent nuclear IkappaB kinase a ctivation triggered by Nkx3.2 enables constitutive nuclear degradation of Ikapp aB-alpha in chondrocytes. (PubMed id 21606193)1 Yong Y....Kim D.W. (2011)
    8. Meox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter. (PubMed id 15024065)1 Rodrigo I....Imai K. (2004)
    9. Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2. (PubMed id 14612411)1 Kim D.W. and Lassar A.B. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 579 HGNC: 951 AceView: BAPX1 Ensembl:ENSG00000109705 euGenes: HUgn579
    ECgene: NKX3-2 H-InvDB: NKX3-2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NKX3-2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NKX3-2 gene:
    Search GeneIP for patents involving NKX3-2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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